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Supplementary Table 1 Differently expressed genes (DEGs) in in LUAD. Gene symbol ADAM28 AK4 ANP32E ASPM AURKA BIRC5 BUB1 BUB1B C1orf106 CCNB1 CCNB2 CD24 CDC20 CDH3 CDK1 CDKN2A CDKN3 CEACAM5 CENPA CENPF CENPU CEP55 COL10A1 Gene name ADAM metallopeptidase domain 28 Adenylate kinase 4 Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E Asp (abnormal spindle) homolog, microcephaly associated (Drosophila) Aurora kinase A Baculoviral IAP repeat containing 5 BUB1 mitotic checkpoint serine/threonine kinase BUB1 mitotic checkpoint serine/threonine kinase B Chromosome 1 open reading frame 106 Cyclin B1 Cyclin B2 CD24 molecule Cell division cycle 20 Cadherin 3, type 1, P-cadherin (placental) Cyclin-dependent kinase 1 Cyclin-dependent kinase inhibitor 2A Cyclin-dependent kinase inhibitor 3 Carcinoembryonic antigen-related cell adhesion molecule 5 Centromere protein A Centromere protein F, 350/400kDa Centromere protein U Centrosomal protein 55kDa Collagen, type X, alpha 1 COL11A1 COL1A1 COL1A2 COL3A1 COL5A1 COL5A2 CP CRABP2 CST1 CXCL13 CXCL14 DLGAP5 DNAJC12 DSP ECT2 EFNA4 ENO1 EZH2 FAP FEN1 FHL2 FKBP11 GALNT7 GCNT3 GGCT GINS1 Collagen, type XI, alpha 1 Collagen, type I, alpha 1 Collagen, type I, alpha 2 Collagen, type III, alpha 1 Collagen, type V, alpha 1 Collagen, type V, alpha 2 Ceruloplasmin (ferroxidase) Cellular retinoic acid binding protein 2 Cystatin SN Chemokine (C-X-C motif) ligand 13 Chemokine (C-X-C motif) ligand 14 Discs, large (Drosophila) homolog-associated protein 5 DnaJ (Hsp40) homolog, subfamily C, member 12 Desmoplakin Epithelial cell transforming 2 Ephrin-A4 Enolase 1, (alpha) Enhancer of zeste 2 polycomb repressive complex 2 subunit Fibroblast activation protein, alpha Flap structure-specific endonuclease 1 Four and a half LIM domains 2 FK506 binding protein 11, 19 kDa Polypeptide N-acetylgalactosaminyltransferase 7 Glucosaminyl (N-acetyl) transferase 3, mucin type Gamma-glutamylcyclotransferase GINS complex subunit 1 (Psf1 homolog) GMNN GOLM1 GPR87 GREM1 HIST1H2BD HMGB3 HN1 IGF2BP3 IGFBP3 IGHM IGHV3-23 IGK IGKV4-1 IGL IGLJ3 IGLV1-40 KDELR2 KIAA0101 KIF11 KIF4A KRT15 LAPTM4B LGR4 LGSN LOC100133862///IGHM LOC100510044///IGK Geminin, DNA replication inhibitor Golgi membrane protein 1 G protein-coupled receptor 87 Gremlin 1, DAN family BMP antagonist Histone cluster 1, H2bd High mobility group box 3 Hematological and neurological expressed 1 Insulin-like growth factor 2 mRNA binding protein 3 Insulin-like growth factor binding protein 3 Immunoglobulin heavy constant mu Immunoglobulin heavy variable 3-23 Immunoglobulin kappa locus Immunoglobulin kappa variable 4-1 Immunoglobulin lambda locus Immunoglobulin lambda joining 3 Immunoglobulin lambda variable 1-40 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 KIAA0101 Kinesin family member 11 Kinesin family member 4A Keratin 15 Lysosomal protein transmembrane 4 beta Leucine-rich repeat containing G protein-coupled receptor 4 Lengsin, lens protein with glutamine synthetase domain Ig heavy chain V-I region V35-like///immunoglobulin heavy constant mu Immunoglobulin kappa locus-like///immunoglobulin kappa locus MAD2L1 MCM4 MDK MELK MMP1 MMP11 MMP12 MMP9 NDC80 NEK2 NME1 NMU NQO1 NUSAP1 PAICS PBK PCP4 PLAU PLOD2 POU2AF1 PPAP2C PRC1 RCC1 RGS17 RRM2 S100A2 MAD2 mitotic arrest deficient-like 1 Minichromosome maintenance complex component 4 Midkine (neurite growth-promoting factor 2) Maternal embryonic leucine zipper kinase Matrix metallopeptidase 1 (interstitial collagenase) Matrix metallopeptidase 11 (stromelysin 3) Matrix metallopeptidase 12 (macrophage elastase) Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) NDC80 kinetochore complex component NIMA-related kinase 2 NME/NM23 nucleoside diphosphate kinase 1 Neuromedin U NAD(P)H dehydrogenase, quinone 1 Nucleolar and spindle associated protein 1 Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase PDZ binding kinase Purkinje cell protein 4 Plasminogen activator, urokinase Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 POU class 2 associating factor 1 Phosphatidic acid phosphatase type 2C Protein regulator of cytokinesis 1 Regulator of chromosome condensation 1 Regulator of G-protein signaling 17 Ribonucleotide reductase M2 S100 calcium binding protein A2 SCG5 SLC2A1 SLC7A11 SORD SOX4 SPAG4 SPINK1 SPP1 SRD5A1 SRPX2 SULF1 TCN1 TFAP2A THBS2 TMPRSS11E TMPRSS4 TOP2A TOX3 TPBG TPX2 TTK TYMS UBE2C ZWINT Secretogranin V (7B2 protein) Solute carrier family 2 (facilitated glucose transporter), member 1 Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 Sorbitol dehydrogenase SRY (sex determining region Y)-box 4 Sperm associated antigen 4 Serine peptidase inhibitor, Kazal type 1 Secreted phosphoprotein 1 Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) Sushi-repeat containing protein, X-linked 2 Sulfatase 1 Transcobalamin I (vitamin B12 binding protein, R binder family) Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) Thrombospondin 2 Transmembrane protease, serine 11E Transmembrane protease, serine 4 Topoisomerase (DNA) II alpha 170kDa TOX high mobility group box family member 3 Trophoblast glycoprotein TPX2, microtubule-associated TTK protein kinase Thymidylate synthetase Ubiquitin-conjugating enzyme E2C ZW10 interacting kinetochore protein