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Supplemental data
Table 1. Clinical and immunological patients’ characteristics, described by mean ± standard deviation,
frequency, median and interquartile range (IQR) when appropriate. Patients were separated into two
groups, according to the development or not of sepsis. Immunological data did not verify normality
(using the Kolmogorov-Smirnov test). Groups were compared using the independent paired t test for
continuous parametric variables (*), the Mann-Whitney U test for continuous non parametric
variables (‡), or the chi-square test for categorical data (▪). A p-value < 0.05 was considered
significant. Statistical analyses were performed with R version 3.0.2 software (R foundation for
Statistical Computing, Vienna, Austria).
Overall population
Septic patients
Non-Septic patients
n=80
n=23
n=57
39 ± 17
32 ± 13
42 ± 18
.02 *
83% (n=60)
83% (n=19)
72% (n=41)
.48 ▪
37 ± 16
42 ± 12
35 ± 8
.002 *
Severe brain injury
41% (n=33)
56% (n=13)
35% (n=20)
.13 ▪
Severe thoracic injury
81% (n=65)
83% (n=19)
81% (n=46)
1▪
42 ± 16
48 ± 14
40 ± 16
.03 *
Need for vasoactive support
in emergency room
41% (n=33)
61% (n=14)
33% (n=19)
.04 ▪
Prophylactic antibiotics in
emergency room
50% (n=40)
57% (n=13)
47% (n=27)
.62 ▪
Mechanical ventilation (MV)
80% (n=64)
96% (n=22)
74% (n=42)
.06 ▪
Length of stay in ICU, days
13 ± 14
25 ± 20
8±6
<.0001 *
Non-survivors at day 28
0% (n=0)
0% (n=0)
0% (n=0)
.06 ▪
D1
7 176 [5 726; 10 460]
7 270 [5 536; 11 470]
7 162 [5 766; 10 410]
.6 ‡
D2
5 758 [4 105; 7 620]
5 491 [4 066; 6 654]
5 857 [4 167; 6 692]
.5 ‡
Parameters
Age (years)
Male
ISS
SAPS II
p value
mHLA-DR levels , antibodies per cell
D3
6 230 [4 352; 10 340]
4 808 [3 247; 8 088]
7 012 [4 580; 10 940]
.06 ‡
D4
7 294 [4 584; 9 800]
5 050 [3 509; 9 467]
8 270 [5 094; 10 910]
.1 ‡
D2 / D1
.7 [.5 ; 1]
.7 [.5 ; .9]
.7 [.5 ; 1]
.7 ‡
D3 / D2
1.1 [.9 ; 1.3]
1 [.6 ; 1.1]
1.2 [1 ; 1.5]
.004 ‡
D4 / D3
1.1 [1 ; 1.3]
1 [.9 ; 1.1]
1.2 [1 ; 1.3]
.1 ‡
Variations in mHLA-DR
Abbreviations: D: Day; HLA: Human Leucocyte Antigen; ISS: Injury Severity Score; SAPS: Simple Acute
Physiology Score; ICU: Intensive Care Unit.
Table 2. Sepsis characteristics
Type of
infection
Pulmonary
infection
Urinary track
infection
Peritonitis
Bacteria involved
Mean delay of
Incidence
occurrence
(days)
Mechanical
Gram-
Gram-
Mixed
positive
negative
infection
ventilation
83% (n=19)
4
53% (n=10)
21% (n=4)
26% (n=5)
95% (n=18)
13% (n=3)
9
67% (n=2)
33% (n=1)
0
NA
4% (n=1)
4
0
0
100% (n=1)
NA
Regarding pneumonia, when a gram-positive bacteria was involved (i.e. pure or mixed infection), the
bacteria responsible was either a Methicillin-sensitive Staphylococcus aureus (80%) or a
Streptococcus pneumoniae (20%). The varieties of gram-negative bacteria involved were larger:
Haemophilus influenzae, Escherichia coli, Klebsiella pneumoniae or oxytoca.