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Jerri Johnson
*OAH_RuleComments.OAH
Immunization Rules docket 0900-30570
Wednesday, July 17, 2013 1:21:36 PM
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World J Gastroenterol. 2007 Apr 21;13(15):2238-9.
Hepatitis A vaccine associated with
autoimmune hepatitis.
Berry PA, Smith-Laing G.
Source
Medway Maritime Hospital, 31 Pentlow Street, Putney, London, SW15 1LX, United
Kingdom. [email protected]
Abstract
To describe a case of probable relapsing autoimmune hepatitis associated with
vaccination against hepatitis A virus (HAV). A case report and review of literature
were written concerning autoimmune hepatitis in association with hepatitis A and
other hepatotropic viruses. Soon after the administration of formalin-inactivated
hepatitis A vaccine, a man who had recently recovered from an uncharacterized but
self-limiting hepatitic illness, experienced a severe deterioration (AST 1687 U/L, INR
1.4). Anti-nuclear antibodies were detectable, and liver biopsy was compatible with
autoimmune hepatitis. The observation supports the role of HAV as a trigger of
autoimmune hepatitis. Studies in helper T-cell activity and antibody expression
against hepatic proteins in the context of hepatitis A infection are summarized, and
the concept of molecular mimicry with regard to other forms of viral hepatitis and
autoimmunity is briefly explored.
Jerri Johnson
Public Relations Coordinator
National Health Freedom Coalition'
651 688 6515
[email protected]