Download Toxicological Summary for 4- tert -Octylphenol (PDF)

Health Based Value for Groundwater
Health Risk Assessment Unit, Environmental Health Division
651-201-4899
Web Publication Date: August 2015
Expiration Date: August 2020
Toxicological Summary for: 4-tert-Octylphenol
CAS: 140-66-9
Synonyms: 4-(1,1,3,3-Tetramethylbutyl)phenol, p-(1,1,3,3-Tetramethylbutyl)phenol, ptert-Octylphenol, 4-(2,4,4-trimethylpentan-2-yl)phenol
Acute Non-Cancer Health Based Value (nHBVAcute) = Not Derived (Insufficient Data)
Short-term Non-Cancer Health Based Value (nHBVShort-term) = 100 µg/L
(Reference Dose, mg/kg-d) x (Relative Source Contribution) x (Conversion Factor)
(Short-term Intake Rate, L/kg-d)
= (0.17 mg/kg-d) x (0.2*) x (1000 µg/mg)
(0.289 L/kg-d)
= 118 rounded to 100 µg/L
*The available data indicate that infant exposures, from sources such as breast milk and baby food, are not lower
than adult exposures. As infant exposures are equal to or exceed adult exposures based on the available exposure
data, a relative source contribution of 0.2 has been selected for all durations.
Reference Dose/Concentration:
Source of toxicity value:
Point of Departure (POD):
Human Equivalent Dose (MDH,
2011):
Total uncertainty factor:
Uncertainty factor allocation:
0.17 mg/kg-d (Sprague-Dawley rats)
MDH, 2015
22 mg/kg-d (NOAEL, Tyl et al. 1999)
22 mg/kg-d x 0.23 = 5.1 mg/kg-d
30
3 for interspecies differences (for toxicodynamics) and
10 for intraspecies variability
Critical effect(s): Decreased pup body weight and increased time to
preputial separation
Co-critical effect(s): Decreased adult body weight
Additivity endpoint(s): Developmental
4-tert-Octylphenol - 1 of 8
Subchronic Non-Cancer Health Based Value (nHBVSubchronic) = (nHBVShort-term) = 100 µg/L
(Reference Dose, mg/kg-d) x (Relative Source Contribution) x (Conversion Factor)
(Subchronic Intake Rate, L/kg-d)
= (0.17 mg/kg-d) x (0.2) x (1000 µg/mg)
(0.077 L/kg-d)
= 442 rounded to 400 µg/L
Reference Dose/Concentration:
Source of toxicity value:
Point of Departure (POD):
Human Equivalent Dose (MDH,
2011):
Total uncertainty factor:
Uncertainty factor allocation:
0.17 mg/kg-d (Sprague-Dawley rats)
MDH, 2015
22 mg/kg-d (NOAEL, Tyl et al. 1999)
22 mg/kg-d x 0.23 = 5.1 mg/kg-d
30
3 for interspecies differences (for toxicodynamics) and
10 for intraspecies variability
Critical effect(s): Decreased uterine weights, decreased pup body
weight, and increased time to preputial separation
Co-critical effect(s): Decreased adult body weight
Additivity endpoint(s): Developmental, Female Reproductive System
The Subchronic nHBV must be protective of the short-term exposures that occur within
the subchronic period and therefore, the Subchronic nHBV is set equal to the Short-term
nHBV of 100 µg/L. Additivity endpoints: Developmental
Chronic Non-Cancer Health Based Value (nHBVChronic) = (nHBVShort-term) = 100 µg/L
(Reference Dose, mg/kg-d) x (Relative Source Contribution) x (Conversion Factor)
(Chronic Intake Rate, L/kg-d)
= (0.051 mg/kg-d) x (0.2) x (1000 µg/mg)
(0.043L/kg-d)
= 237 rounded to 200 µg/L
Reference Dose/Concentration: 0.051 mg/kg-d (Sprague-Dawley rats)
Source of toxicity value: MDH, 2015
Point of Departure (POD): 22 mg/kg-d (NOAEL, Tyl et al. 1999, subchronic
exposure)
Human Equivalent Dose (MDH, 22 mg/kg-d x 0.23 = 5.1 mg/kg-d
2011):
Total uncertainty factor: 100
Uncertainty factor allocation: 3 for interspecies differences (for toxicodynamics), 10
for intraspecies variability, and 3 for subchronic to
chronic extrapolation
Critical effect(s): Decreased uterine weight, decreased pup body weight,
and increased time to preputial separation
Co-critical effect(s): Decreased adult body weight
4-tert-Octylphenol - 2 of 8
Additivity endpoint(s): Developmental, Female Reproductive System
The Chronic nHBV must be protective of the short-term and subchronic exposures that
occur within the chronic period and therefore, the Chronic nHBV is set equal to the
Short-term nHBV of 100 µg/L. Additivity endpoints: Developmental
Cancer Health Based Value (cHBV) = Not Applicable
Volatile:
Yes (low)
Summary of Guidance Value History: No previous guidance from MDH
Summary of toxicity testing for health effects identified in the Health Standards Statute
(144.0751):
Even if testing for a specific health effect was not conducted for this chemical, information about that effect might be
available from studies conducted for other purposes. MDH has considered the following information in developing
health protective guidance.
Tested for specific
effect?
Effects observed?
Endocrine
Yes
Immunotoxicity
No
Development
Yes
Reproductive
Yes
Neurotoxicity
Yes
Yes1
--2
Yes3
Yes4
Yes5
Comments on extent of testing or effects:
1
Endocrine effects such as increased uterine weights, increased vaginal and uterine thickness,
and changes in estrus cyclicity were reported in female rats receiving doses approximately 35275 times higher than the short-term RfD. In addition, male animals receiving doses
approximately 225 times higher than the short-term RfD had increased prolactin levels.
2
No oral studies specifically evaluating immunotoxicity have been conducted. Studies
examining other endpoints reported reduced thymus and spleen weights at approximately
300 times higher than the short-term RfD, and increased white blood cell/platelet counts
around 650-700 times higher than the short-term RfD.
3
The short-term RfD is based on reduced pup body weights and delayed preputial separation
after rats were exposed to 4-tert-Octylphenol through their diet. Precocious vaginal patency
was observed at doses more than 250 times the short-term RfD.
4
The subchronic and chronic reference doses are based on reduced uterine weights of rats
exposed to 4-tert-Octylphenol through their diet. In other studies, doses more than 650 times
higher than the short-term RfD resulted in changes in epididymis and prostate weights. In
addition, an increase in post-implantation loss and the reduction of number of live fetuses per
litter were observed at doses 41-160 times higher than the short-term RfD.
5
Neurobehavioral effects, including effects on a variety of sexually dimorphic behaviors and
water maze performance, were evaluated in a single oral study. The effects occurred at an
estimated dose approximately 150 times higher than the short-term RfD.
4-tert-Octylphenol - 3 of 8
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