Download Dimethenamid ESA Dimethenamid OXA (PDF)

2013 Health Based Value for Groundwater
Health Risk Assessment Unit, Environmental Health Division
651-201-4899
651-201-5797 TDD
Web Publication Date: June 2013
Expiration Date: June 2018
Chemical Name:
Dimethenamid Degradates: ESA and OXA
CAS: 205939-58-8 (ESA) and no CAS identified (OXA)
Dimethenamid ESA: Ethanesulfonic acid degradate of dimethenamid
Dimethenamid OXA: Oxanilic acid degradate of dimethenamid
MDH finds there is insufficient toxicity information available for dimethenamid ESA and OXA to
develop chemical specific guidance for groundwater.
The dimethenamid ESA and OXA degradate guidance values will be issued as Risk Assessment Advice
(RAA) and will be based on the Health Based Values (HBVs) of the parent compound, dimethenamid.
This approach is consistent with the approach outlined in the Minnesota Statute 103H.201 Health Risk
Limit Rules, Section 4717.7900 Chemical Breakdown Products.
The HBV values for dimethenamid are:
Short-term – 600 ug/L
Additivity Endpoints – Developmental, Hepatic (liver) system, Nervous
system, Reproductive system (Female)
Subchronic – 600 ug/L Additivity Endpoints – Developmental, Hepatic (liver) system, Nervous
system, Reproductive system (Female)
Chronic – 300 ug/L
Additivity Endpoints – Hepatic (liver) system
For additional information about the derivation of the HBVs for
http://www.health.state.mn.us/divs/eh/risk/guidance/gw/dimethensumm.pdf.
dimethenamid
see:
Dimethenamid ESA and OXA degradates have not been classified as to their carcinogenic potential. The
parent compound, dimethenamid, is classified as a group C “possible human carcinogen” so a nonlinear
approach was used to evaluate whether the chronic RfD is protective of potential cancer effects. MDH
determined that the dimethenamid chronic RfD (0.06 mg/kg-d) is protective for cancer risk.
Volatile: Yes (moderate)
Summary of Guidance Value History:
No previous chemical specific MDH guidance exists for dimethenamid ESA and OXA. The MDH Risk
Assessment Advice developed in 2013 represent new values. For the guidance history for dimethenamid see:
http://www.health.state.mn.us/divs/eh/risk/guidance/gw/dimethensumm.pdf.
Dimethenamid ESA and OXA - 1 of 3
Summary of toxicity testing for health effects identified in the Health Standards Statute:
Endocrine
Immunotoxicity Development
Reproductive
Neurotoxicity
Tested?
No
No
No
No
No
Effects?
No
No
No
No
No
Note: Even if testing for a specific health effect was not conducted for this chemical, information about that effect might be
available from studies conducted for other purposes. Most chemicals have been subject to multiple studies in which
researchers identify a dose where no effects were observed, and the lowest dose that caused one or more effects. A toxicity
value based on the effect observed at the lowest dose across all available studies is considered protective of all other effects
that occur at higher doses.
References:
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Intakes for Agricultureal and Veterinary Chemicals." from
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00770C2A/$File/ADI-Dec12.pdf.
Australian Pesticides and Veterinary Medicines Authority. (2007). "Evalutation of the active
dimethenamid-P in the product Frontier - P Herbicide." from
http://www.apvma.gov.au/registration/assessment/docs/prs_dimethenamid-p.pdf.
California Environmental Protection Agency - Department of Pesticide Regulation (2005). Summary of
Toxicology Data, Dimethenamid-P.
European Commission (2003). Review report for the active substance dimethenamid-p. Health &
Consumer Protection Directorate-General.
Hooks (1990). SAN 582 H: Potential tumourigenic effects in prolonged dietary administration to mice.
Huntingdon, England, Huntingdon Research Centre.
Minnesota Department of Health (MDH). (2011). "MDH Health Risk Assessment Methods to
Incorporate Human Equivalent Dose Calculations into Derivation of Oral Reference Doses."
from http://www.health.state.mn.us/divs/eh/risk/guidance/hedrefguide.pdf.
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Millstone, New Jersey, Unpublished report No. 96/11147 from Huntingdon Life Sciences.
Submitted to WHO by BASF.
Ruckman (1990). SAN 582 H: potential tumorigenic and toxic effects in prolonged dietary
administration to rats. Huntingdon, England, Unpublished report No. 90/11138 Huntingdon
Research Centre. Submitted to WHO by BASF.
Suter P (1989). SAN 582 H: two-generation reproduction study in the rat., Research & Consulting
Company AG.
Dimethenamid ESA and OXA - 2 of 3
U.S. Environmental Protection Agency - Office of Pesticide Programs. "Human Health Benchmarks for
Pesticides." from http://www.epa.gov/pesticides/hhbp.
U.S. Environmental Protection Agency - Office of Research and Development. (1988).
"Recommendations for and Documentation of Biological Values for Use in Risk Assessment."
from http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=34855.
U.S. Environmental Protection Agency - Office of the Science Advisor. (2011). "Recommended Use of
Body Weight¾ as the Default Method in Derivation of the Oral Reference Dose." from
http://www.epa.gov/raf/publications/pdfs/recommended-use-of-bw34.pdf.
U.S. Environmental Protection Agency (EPA) (1991a). Memorandum: Expedited Review re:
SAN582H/Experimental Use Permit. Office of Pesticides and Toxic Substances.
U.S. Environmental Protection Agency (EPA) (1992). Memorandum: Carcinogenicity Peer Review of
SAN 582H. Office of Pesticides and Toxic Substances.
U.S. Environmental Protection Agency (EPA) (2007a). Memorandum--Dimethenamid-p. Human Health
Risk Assessment for proposed use on grasses grown for seed, PC Codes: 120051 and 129051,
Petition No: 0F6138, DP Num: 337887. P. Office of Prevention, and Toxic Substances,.
U.S. Environmental Protection Agency (EPA) (2007b). Memorandum--Dimethenamid-p. AMENDED
Human Health Risk Assessment for proposed use on grasses grown for seed, PC Codes: 120051
and 129051, Petition No: 0F6138, DP Num: 337887. P. Office of Prevention, and Toxic
Substances,.
U.S. Geological Survey - Health-Based Screening Levels. from
http://infotrek.er.usgs.gov/apex/f?p=HBSL:HOME:0.
World Health Organization (2005a). Joint FAO/WHO Meeting on Pesticide Residues.
World Health Organization (2005b). WHO Meeting Dimethenamid-P/Racemic Dimethenamid.
York (1996). Oral (gavage) developmental toxicity study of SAN 1289 H in rats. Horsham,
Pennsylvania, Unpublished report No 97/5274 from Argus Research Laboratories. Submitted to
WHO by BASF.
Dimethenamid ESA and OXA - 3 of 3