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Dr Kortnye Smith Medical Oncology Fellow Medical Management (+management of sick cancer patient) Introduction to Peter Mac Peter Mac Structure - Tumour Streams: Specialty specific - Outpatients, MDM, Consults • Includes Surgeons/Med Onc/Rad Onc /Haem/Physicians/Nurse Coordinators/ Palliative Care/Radiologist/Pathologist/Radiation Therapists/Other specialists/AYA/ Psych/ Pharmacists Inpatient Units Inpatient Units - Haematology - Medical oncology - Surgical Oncology No bed card for: - Palliative care - General medicine (admitted under home team) - Radiation Oncology (admitted under Medical or Surgical Oncology depending on cause for admission) PMCC Specific Consulting Units - Palliative care - General Medicine - Respiratory Medicine - Cardiology - Endocrinology - Acute Pain Psychiatry Familial Cancer Adolescent and Young Adult Acute Assessment Unit - Higher Acuity Nursing - General Medicine and HDU Assistance - What its used for: - New direct to hospital admissions (not all) - Admissions from ED (particularly outside precinct) that need rapid assessment on the ward - Short term overnight admissions (Chemo-reaction in CDU/Transfusion etc.) - Higher nursing requirements - Not a HDU - Additional Support Provided by RMH ICU Medical Day Unit What is it for: - Short treatments: - transfusions, drug education (i.e. enoxaparin) - Rapid Clinical Assessments of Outpatients - Observation - ? Able to be discharged ? Do they need admission Patients in the RMH - Most units will have patients in Royal Melbourne - Haem: transplant patients Med Onc: overflow patients Intensive Care Unit Emergency - Important - Nurses need to be able to contact you - Make sure you know who the after hours RMO at RMH is covering your patients- hand over as required - Switch can be challenging, especially at night- try to give direct numbers - Night RMO at PMCC can’t leave the building Useful resources in the Hospital Person: - Registrars and Fellows - Including other specialties - Nurse Co-ordinators (via tumour stream) - Nursing staff – Ward, AAA, CDU, MDU, Apheresis - Diagnostic imaging – Access Coordinator - Patient Service Manager - Pharmacists, Drug Information After Hours – Limitations - Palliative Care: - has 24 HOUR on call service, call early if concerned - Radiology: - Standard in-hours service only- nil standard on weekends - Will come in for all medically required scans - (discussion with radiology a/hours and at weekends) - Pathology: - Need to call for urgent overnight results (ie. LP) - Bloods standard - Limited: - Security Assistance - Psychiatric resources - Interventional radiology Clinical Viewer Clinical Viewer: Good thing Clinical Viewer: More Good things Oncology Terminology: Medical Therapy - Chemotherapy - Neo-adjuvant / Adjuvant - Palliative– 1st / 2nd /3rd line treatment - Maintenance chemo - Concurrent / sequential - Chemotherapy Cycle - C1D1, C1D8, C2D1 • Oncologists and Hematologists are pedantic, they always want this detail • Important to know days since last chemotherapy cycle. Oncology Terminology: Radiation + Surgical - Radiation - Curative - Palliative - Concurrent - Surgery - Curative - De-bulking - Palliative Unit Admissions - Include - Medical Treatment • Curative or palliative intent • Date of diagnosis • Treating doctor • Previous treatment – Chemo, ? any radiotherapy (to where), surgery • Cycle - ECOG status - Resuscitation status • Check ACP (write ACP) Oncology Medications • Categories - Chemotherapy Hormonal therapy Immune therapy Targeted agents • Each have specific side effects • Often given in combination - E.g. FOLFOX, FEC-D, R-CHOP YOU CAN’T LEARN THEM ALL, LOOK THEM UP (eVIQ) Common After Hours Calls - Fever – line (Hickman/PICC/Portacath) - Pain - Bone, muscular, neuropathic, other - Nausea and vomiting Shortness of breath Arrhythmia General decline, Falls Oncology emergencies Oncology Medications: Precautions BEWARE OF: - Lots of drug-drug interactions - Restrictions of drugs - Suppression of Immune System - Clinical Trials - Sarcoma Chemotherapy - Methotrexate: Antibiotics (including penicillins) - Immunotherapy - DO NOT GIVE STERIODS without checking first - Clinical Trials - Lots of contra-indicated drugs Oncology Emergencies - Febrile neutropenia (neutrophils <1.0) - Usually 7-10 days post treatment - See protocol (+ talk later today) - Cord compression - urgent MRI, steroids, neurosurgery, RT - SVC obstruction - steroids, RTx, interventional radiology - Pulmonary embolus - Pain crisis Oncology Emergencies - 2 - Tumour lysis syndrome - Hyperkalaemia, hyperphosphatemia, hyperuricemia, hypocalcaemia - Hyperhydration, urinary alkalization, allopurinol - Hypercalcaemia (hydration, diuretics, bisphosphonates, calcitonin, steroids) - Ca(corrected) = Ca(measured) + (40-Alb) x 0.02 - Hyponatraemia - SIADH (fluid restrict, demeclocycline, hypertonic saline) Oncology Emergencies 3 - Bowel obstruction - Immune phenomena - Colitis - Endocrinopathy - Skin toxicity - Extravasation Useful Online resources - Peter Mac INTRANET - GUIDELINES - eviQ - www.eviq.org.au - www.cancer.gov - UptoDate - Therapeutic Guidelines