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Medical Microbiology and Infectious Diseases faculty interested in hosting an undergraduate student applying for the Undergraduate Research Awards: Name: Denice Bay Photo (optional): Contact information including website address: Rm 514C Basic Medical Sciences Bldg. Department of Medical Microbiology and Infectious Diseases University of Manitoba 745 Bannatyne Avenue Winnipeg, MB, Canada R3E 0J9 Tel: (204) 977-5679 Fax: (204) 789-3926 Email: [email protected] Website: http://umanitoba.ca/faculties/health_sciences/medicine/units/medical_microbiology/faculty/denicebay .html Short Description of Research (3-4 sentences): Examination of bacterial multidrug transporters and their lipid dependence to understand their function, evolution, and structural biology using a multidisciplinary approach involving molecular biology, microbiology, biochemistry, biophysics, and bioinformatics. Characterizing the antimicrobial resistance of multidrug resistant efflux pumps transmitted via horizontal gene transfer between Enterobacteriaceae. Developing screening arrays to identify antiseptic/disinfectant resistance mechanisms among multidrug resistant bacteria. Medical Microbiology and Infectious Diseases faculty interested in hosting an undergraduate student applying for the Undergraduate Research Awards: Name: Kevin Coombs Photo (optional): Contact information including website address: Manitoba Centre for Proteomics & Systems Biology 799 John Buhler Research Centre 204-789-3976 [email protected] http://umanitoba.ca/faculties/health_sciences/medicine/ units/medical_microbiology/faculty/KevinCoombs.html Short Description of Research (3-4 sentences): Our lab is interested in understanding virus structure-function, assembly and pathogenesis, with most recent focus on delineating how virus infection alters and is dependent upon the cellular proteome. We study a variety of viruses, including reovirus, influenza and Zika virus. Our recent proteomic screens identified several key cellular pathways such as apoptosis, autophagy and the Ubiquitin-proteasomal system that these viruses require and we are currently elucidating exactly how these cell signaling pathways affect the capacity of these viruses to replicate. Medical Microbiology and Infectious Diseases faculty interested in hosting an undergraduate student applying for the Undergraduate Research Awards: Name: Keith R. Fowke Photo (optional): Contact information including website address: Keith R. Fowke, Ph.D. Professor and Head, Laboratory of Viral Immunology Department of Medical Microbiology and Infectious Diseases Max Rady College of Medicine Rady Faculty of Health Sciences 539-745 Bannatyne Avenue Winnipeg, Manitoba Canada R3E 0J9 Telephone (204) 789-3818 Fax (204) 789-3926 http://umanitoba.ca/faculties/health_sciences/medicine/units/medical_microbiology/faculty/KeithFow ke.html Short Description of Research (3-4 sentences): The Laboratory of Viral Immunology is a vital, active laboratory focused on training young scientists through basic science studies in HIV infection. The lab studies why some people who are exposed to HIV do not become infected and how we can use that information to prevent infection in others. We also study how an over-activated immune response is a risk factor for acquiring HIV or for rapid disease progression once infected. The lab is supported through funding by the Canadian Institutes for Health Research and works in partnership with academic and community groups in Nairobi, Kenya and Winnipeg, Manitoba. Medical Microbiology and Infectious Diseases faculty interested in hosting an undergraduate student applying for the Undergraduate Research Awards: Name: Dr. Ehsan Khafipour Photo (optional): Contact information including website address: [email protected] http://www.khafipourmicrobiomelaboratory.com Short Description of Research (3-4 sentences): The role of lifestyle factors, such as physical activity, nutrition, and sleep, in human health and disease is well established. These lifestyle factors are often targeted by prevention and treatment strategies to reduce chronic conditions, such as metabolic syndrome, diabetes, obesity and cardiovascular disease. However, how these modifiable lifestyle factors interact with newer determinants of health, such as gut microbiome and metabolic phenotype of the individual is relatively unknown. Both host genetics and environmental exposures throughout the life (such as method of birth, breastfeeding, diet, and medication use) can have life-long impact on gut microbiome. Gut microbiome on the other hand has been shown to impact host physiology, metabolism, and immune function and to confer indirect (immune-mediated) and direct resistance against enteric pathogens. Disruption of gut microbiome or dysbiosis – which is referred to an abnormal balance of beneficial and protective members of microbiota – has been linked to a growing number of chronic conditions such as obesity, insulin resistance and inflammatory bowel diseases. The dysbiosis of gut microbiome impacts the profile of microbially-drived metabolites and small molecules produced by the microbiota. These molecules influence the metabolic and immunological capacities of the host both within and outside of the gut, i.e. through enterohepatic pathway or gut-brain axis. Given the dynamics of the gut microbiome and metabolome, and their potentially causal roles in multiple chronic diseases, microbiome and metabolome profiles of individuals can be used as personalized biomarkers of health status, and thus, as targets for intervention. During the phase I of this research program, we are conducting a cross-sectional investigation of the interaction between lifestyle, genetics, and gut microbiota and how these are associated with additional risk factors for chronic conditions prevalent in Manitobans, such as obesity, type 2 diabetes, metabolic syndrome, and cardiovascular disease. Student will be involved in recruiting subjects and collection of information and samples as well as DNA extraction, PCR amplification, bacterial sequencing and bioinformatics analyses of data. For more information about this project please visit: https://tmplr.ca/home Medical Microbiology and Infectious Diseases faculty interested in hosting an undergraduate student applying for the Undergraduate Research Awards: Name: Kelly S MacDonald Photo (optional): Contact information including website address: Head, Infectious Diseases Sellers Research Chair Professor of Internal Medicine & Medical Microbiology University of Manitoba Mail: 501-745 Bannatyne Ave, Winnipeg, MB, R3E 0J9 Email: [email protected] Phone: 204-977-5680 Short Description of Research (3-4 sentences): Dr. MacDonald research focuses on the development an effective HIV/SIV vaccine that induces a robust cellular immune response in the genital mucosa, the natural site of infection. She has concentrated her efforts on the use of Herpes family viruses, particularly Varicella Zoster Virus and Cytomegalovirus, as viral vaccine vectors. Herpes viruses are well adapted to their hosts and are able to persist within the host causing life-long infections. These adaptations are what make Herpes viruses an ideal vector for an HIV/SIV cellular vaccine that can provide life-long protection. Medical Microbiology and Infectious Diseases faculty interested in hosting an undergraduate student applying for the Undergraduate Research Awards: Name: Thomas Murooka Photo (optional): Contact information including website address: Thomas Murooka Assistant Professor 750 McDermot Ave, Room 433 Phone (204) 789 3941 Fax (204) 789 3921 Email: [email protected] Website: www.murookalab.ca Short Description of Research (3-4 sentences): Our lab is interested in using advanced microscopy to visualize cellular motility during infection. The idea is to study natural cellular functions in their most natural environment, and how infectious agents such as bacteria and viruses, can alter these behaviors to block the immune system. By working in our lab, students will be exposed to lab techniques in Molecular biology, Microbiology, Immunology and Infectious Disease, and gain a deeper understanding of host-pathogen interactions. Medical Microbiology and Infectious Diseases faculty interested in hosting an undergraduate student applying for the Undergraduate Research Awards: Name: Xiangguo Qiu Photo (optional): Contact information including website address: Dr Xiangguo Qiu, National Microbiology Laboratory, Public Health Agency of Canada Tel: (204) 784-7548 (O) (204) 789-5097 (Lab) E-mail: [email protected] Web link: http://umanitoba.ca/faculties/health_sciences/medicine/units/medical_microbiology/faculty/xiangguo qiu.html Short Description of Research (3-4 sentences): I am actively doing research in the diagnosis, prevention, and treatment of high-risk pathogens such as Ebola, Marburg, and Lassa viruses. With our modern high-containment lab and facilities, productive works have been shown in my lab related to the development of vaccines and antiviral therapeutics. We would like to have a student who has interest in immunology, virology, and molecular biology. Medical Microbiology and Infectious Diseases faculty hosting an undergraduate student applying for Undergraduate Research Awards: interested the in Name: Xiaojian Photo Yao (optional): Contact information including website address: XiaoJian Yao, Professor, Director, Lab. of Mol. Human Retrovirology Dept. of Medical Microbiology University of Manitoba 204-977-5677 [email protected] http://umanitoba.ca/faculties/health_sciences/medicine/units/medical_microbiology/faculty/xiaojian_y ao.html Short Description of Research (3-‐4 sentences): My lab is mainly working on the molecular biology of HIV, and the development of viral vector based anti-cancer vaccine approach. There is two new projects on going: 1) the biological role and impact of host CD40L on HIV replication; 2) Anticancer vaccine development with viral vectors. Medical Microbiology and Infectious Diseases faculty interested in hosting an undergraduate student applying for the Undergraduate Research Awards: Name: Dr. George G. Zhanel Photo (optional): Contact information including website address: George G. Zhanel Professor-Department of Medical Microbiology and infectious Diseases Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba Director-Canadian Antimicrobial Resistance Alliance (CARA, www.can-r.ca), MS673 Microbiology, Health Sciences Center, 820 Sherbrook Street, Winnipeg, CANADA R3A 1R9, Ph: 204 787-4902, Fax: 204 787-4699 Email: [email protected] Short Description of Research (3-4 sentences): The focus of the research is the study of infections caused by antimicrobial resistant superbugs. The lab already consists of undergraduate students, graduate students, medical students, technicians, clinicians and scientists. An excellent opportunity for a gifted student to come and work and enjoy being around other successful individuals.