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Liverpool Community Health NHS Trust Guidelines for Carbapenemase Producing Enterobacteriaceae – (CPE) 1 Version Number: 1 Ratified by: Clinical Policies Group Date of Approval: February 2015 Name of originator/author: Infection Prevention & Control Team Approving Body / Committee: Clinical Policies Group Date issued (Current version): May 2015 Review date (Current Version): May 2016 Target Audience: LCH Staff & Clinical staff within Nursing & Residential Homes HMP Liverpool Name of Lead Director / Amanda Pye- Director of Infection Managing Director: Prevention and Control Changes / Alterations Made To Previous Version: New Policy May 2015 2 Contents Section Page Number 5 1 Introduction 2 Purpose / Scope 5 3 Definitions 6 4 Duties 6 5 Equality Analysis 7 6 Implementation, Monitoring and Review 7 7 Risk Factors 7 8 8 10 10 Guidance for Staff Caring for a Patient within Domestic Settings Role of the Infection Prevention and Control nurse Intermediate Care Arrangement 11 Protecting Patients from Infection 12 12 Hand Hygiene 13 Cleaning & Decontamination of equipment & 14 9 13 10 environment 14 Treatment & Therapies 14 15 Removing Patients from Isolation 15 16 References 15 Annex Annex 1 Patient Pathway Management Annex 2 GP Information Letter for discharge of CPE positive patient Annex 3 Information leaflet for patients in North West England Annex 4 Patient Hand held Card 3 1. Introduction Enterobacteriaceae are bacteria that usually live harmlessly in the gut of humans. This is called ‘colonisation’ (a person is said to be a ‘carrier’). However, if the bacteria get into the wrong place, such as the bladder or bloodstream they can cause infection. Examples of these bacteria are E.coli, Klebsiella and Enterobacter. They may also be referred to as gram negative bacteria. Carbapenemase are enzymes (chemicals), made by some strains of these bacteria, which allow them to destroy Carbapenemase antibiotics e.g. Meropenem, imipenem, ertapenem etc. the bacteria are therefore resistant to this group of antibiotics. Until now, Carbapenemase antibiotics have been used to successfully treat certain ‘difficult’ infections when other antibiotics have failed to do so. In a hospital, where there are many vulnerable patients, spread of resistant bacteria can cause problems with potentially a significant mortality rate. If a person is a carrier of Carbapenemase-producing Enterobacteriaceae (sometimes called CPE), they do not need to be treated. However, if the bacteria have caused an infection then antibiotics will be required and few, if any, are available. The bacteria spread from person to person with transfer facilitated by contaminated hands, equipment and surfaces adjacent to the colonised/infected person. 2 Purpose / Scope This is a clinical policy document for use in Liverpool Community Health NHS Trust (LCH). The purpose of this policy is to identify Carbapenemase Producing Enterobacteriaceae (CPE); from individual colonised cases and to prevent the risk of transmission This policy applies to healthcare personnel working within LCH. It also applies to private contractors working on Trust premises including, locum, agency staff and volunteers. 4 This guidance provides detail for the management and care of patients within the inpatient ward areas in Intermediate care and for LCH staff caring for patients with CPE in the domestic / shared care setting. LCH has developed this guideline to fulfil the requirements of patients / service users receiving care from staff within LCH. LCH is committed to ensuring that all staff are trained and equipped to perform their role effectively. LCH staff will identify CPE infection in colonised and symptomatic patients and will provide quality and consistency in the delivery of clinical care when caring for an individual with known or suspected CPE. All staff working for or on behalf of LCH will provide care, management and control CPE within the healthcare setting and community in accordance with the latest research based evidence. This guidance was developed in accordance with partner organisations CPE procedures and guidance contained within acute trust toolkit for the early detection, management and control of CPE. Public Health England (2013) 3 Definitions Cephalosporin’s-Broad spectrum antibiotics used in the treatment of septicaemia, pneumonia, meningitis, biliary tract infections, peritonitis and urinary tract infections. Examples include-Cefalexin, Cefotaxime Ceftriaxone, Ceftazidine and Cefuroxime. Enterobacter –organisms that colonise the intestines of humans and animals e.g. ESBL-Extended Spectrum Beta Lactamase. Gram negative bacteria e.g. Escherichia coli that produce an enzyme that breaks down commonly used antibiotics e.g. penicillin’s and render them ineffective. E Coli- Gram negative bacteria that colonise the bowel. IP&CT-Infection Prevention and Control Team MDR- Multi Drug Resistance. Quinolones e.g Ciprofloxacin-Broad spectrum, synthetic antibacterial agents particularly for use against gram negative bacteria. 5 4 Duties All LCH staff are responsible for co-operating with the development and implementation of clinical policies as part of their normal duties and responsibilities. All other personnel will be expected to comply with the requirements of all relevant LCH policies applicable to their area of operation. All potential adverse incidents should be reported in line with LCH Incident reporting policy. 5. Equality Analysis-an impact assessment has been undertaken and kept by the author 6. Implementation, Monitoring and Review 6.1 The implementation of this policy will be undertaken by users. The policy should be disseminated via communication cascades including staff and team meetings. It is the responsibility of all managers to ensure staff distribution of LCH wide and local policies in their areas. 6.2 This policy will be made available on the staff intranet once approved and published on the internal and external LCH Websites 6.3 Monitoring of staff compliance to policy and guidance remains a line management responsibility. Managers with line management responsibility are responsible for implementation of policies and guidance and reporting non-compliance. 6.4 These guidelines have been developed and peer reviewed by the following professional groups: The Infection Prevention and Control team Clinical Policies working group 7. Risk Factors for CPE-: CPE occurs in all ages, but is more likely to be seen more in the elderly as they are more likely to be hospitalised/screened, but young people are also at risk. 6 Risk factors for CPE include the following: Travel abroad- particularly within the last twelve months where CPE is prevalent. Healthcare abroad- hospitals/countries where CPE is prevalent. Direct inter-Healthcare transfers either locally or nationally. Past admission to a hospital in the UK known to have a CPE problem Any previous hospital admission Previous contact with a CPE case; family member, or hospital contact with a case. Colonisation with another MDR organism especially ESBL-due to the use of selective antibiotics. Presence of invasive devices. Antibiotics-Broad spectrum e.g. cephalosporin’s, quinolones, and clindamycin which are harmful to gut flora. Serious underlying disease/illness. Immune compromised conditions. 8. Guidance for Staff caring for a patient within domestic settings Strict adherence to standard Infection Prevention and Control precautions is essential in preventing the spread of infection-please refer to Standard Precautions Policy. Where possible make the patient the last visit of the day. Compliance with Hand Hygiene is essential. Hands should be washed with liquid soap and disposable paper towels before and after patient contact. Alcohol gel can be used for hand hygiene if hands are visibly clean (unless diarrhoea is evident). Liverpool Community Health staff can acquire individual liquid soap and hand gel bottles together with paper towels from procurement. Encourage good hand 7 hygiene practice with the patient, especially if they develop loose stools or diarrhoea. Personal Protective Equipment (PPE) must be worn – Non sterile Vinyl disposable single use only gloves. Disposable plastic aprons to be used for close contact/clinical procedures. Remove gloves first as these will be the most contaminated followed by aprons and dispose of in clinical waste bags Hand hygiene must always be performed prior to donning and removal of PPE. Decontamination of all patient equipment must be performed after every use with detergent based wipes as per decontamination of medical devices policy. Any equipment that cannot be effectively cleaned should be condemned. If patient is generating clinical waste, this could include waste from continence products by those patients known to be colonised and having loose stools/diarrhoea, please arrange for a clinical waste pick up. For patients within the Liverpool area please ask district nurse team leader to complete clinical waste referral form and fax to Liverpool waste contractor 01132700347 (telephone 03332404400). For Sefton residents please contact LCH infection prevention and control team on 0151 295 3036. For Knowsley patients with a Liverpool GP please contact infection Prevention and Control on 0151 295 3036 Until the clinical waste is set up and running, ensure that any waste is double bagged if entering the domestic waste stream. Scrupulous Infection prevention and Control Practices are particularly important when caring for indwelling devices/equipment. For e.g. Urinary catheters, enteral feeding equipment, central venous catheter lines, colostomy or ileostomy, wound dressings as these provide a direct route of entry into the patient’s body. Consider if such devices are necessary and remove if not. Strict adherence to aseptic technique is crucial in preventing the spread of infection. Loose stools or diarrhoea increase the risk of spread of gut bacteria; therefore advise the patient of the need for scrupulous general hygiene including hand washing and cleaning of the environment to 8 reduce the risk of transmission of infection. Any unexplained diarrhoea should be reported to patients GP. N.B it should be noted that if the patient is colonised or infected , then no antibiotic or decolonisation treatment is required for the following reasons; Skin decolonisation-not advised as these bacteria generally colonise the gut rather than the skin. Gut decolonisation (by prescribing antibiotics) this is not advised as antibiotic therapy could contribute to increasing resistance in the longer term. If the patient becomes infected then antibiotic therapy will depend upon sensitivity results. GP’s should take advice from local microbiology departments. For further advice contact Infection Prevention and Control at; [email protected] Telephone: 0151 295 3036 9. Role of the Infection prevention and control team (IP&CT) When patients are found to be CPE positive within community settings, the IPCT will Inform GP and advice caution with antibiotic prescribing Please see annex 2 Establish and assess risks including, indwelling devices, wounds, twelve month history of travel and community healthcare interaction. Assess risk and give advice re indwelling devices. If no longer required to remove at first opportunity. Identify if patient attends outpatients appointments and to inform relevant department. Has the patient been in hospital in the last the last 12 months? Inform relevant organisation. Current Care-identify current providers of health and social care. Ensure that they have been informed of CPE status and that appropriate Infection Prevention and Control advice is given. 9 Send patient CPE Card and information leaflet. 10. Intermediate Care Arrangements Identification of Carbapenemase Producing Enterobacteriaceae (CPE) Patients: For patients transferred to another healthcare provider, it is the responsibility of the transferring hospital / ward to inform the receiving ward if the patient has been tested positive for CPE see Annex 3 GP Admissions: GP’s are now notified when any patients are tested positive. They are advised to inform any healthcare provider if a patient has been previously tested positive for CPE. Patients will also be given a CPE card and are asked to present this, if admitted to hospital. CPE Patient Pathway: Implement CPE patient pathway see Appendix 1 for all CPE patients to ensure correct management across the patient journey and across organisations. Contact screening: Where this is required it will be requested by a member of the infection prevention and control team. Where a whole ward has to be screened the screening swabs are rectal swab, catheter specimen of urine and wound swab. If not possible, a stool sample can be submitted. The Infection Prevention and Control team will compile a list of patients to be screened for Intermediate Care. Flagging of case notes and ICE: All confirmed positive patients will be flagged on the alert on ICE/SIGMA as being colonised with a Multidrug resistant micro-organism (MDR). Case notes and SIGMA will also be flagged with an infection control alert. 10 Contacts requiring screening on readmission are flagged on the infection control data base and a member of the infection prevention control team will alert the ward. Patient Information Leaflets: Please ensure all CPE patients are given CPE leaflets (Public Health England CPE tool kit). Copies should be made available for visitors on request. Please see Annex 3 Isolation Precautions: All patients known or suspected to be CPE positive must be isolated and IP & CT informed. Patients must have their own equipment e.g. blood pressure monitoring machines and hoists should not be shared with other patients. Unless advised otherwise by a member of the infection Prevention and control team disposable gowns and gloves must be worn. There is a specific isolation door notice to be used now available from reprographics. Enhanced Contact Precautions: Health care Works (HCW’s) when nursing a patient with diarrhoea need to utilise gowns to provide greater protection. 11. Protecting patients from infection: The lack of antibiotics available to treat patients who develop infections caused by strains of these resistant bacteria means any lapses in practice are likely to have serious consequences for colonised patients ant the risk of cross infection to other patients. The bacteria are carried in the bowel but may be found on the patients’ skin and hands and immediate environment. It is essential these are not introduced into the patients’ blood stream or other vulnerable site where they can cause an infection. Adherence to asepsis is essential and all invasive devices must be removed as soon as no longer required. 11 All patients who have a long term urinary catheter or a urinary catheter which was not removed prior to transfer must be provided with a completed urinary catheter passport. If identified as CPE positive there is a section to record this in the catheter passport. The patient’s GP and any healthcare teams who will be caring for a positive patient following discharge or transfer must be informed about patients who are CPE positive. e.g. District nurses, nursing homes, other level 2 beds within community care facilities and clinical teams in receiving hospitals. (please refer to Appendix 3). The infection prevention & control team (IPCT) must be informed and will assist by providing any additional advice required. If CPE is identified within Intermediate Care the IPCT will inform the GP and they will also ensure that the patient is given a CPE card. 12. Hand hygiene: Alcohol hand gel correctly used on visibly clean hands is effective for hand decontamination for both patients and staff. Hand hygiene after using the toilet is particularly important for patients. As CPE are carried in the bowel there may be colonised patients who we are unaware of therefore Faulty hand wash basins and toilet facilities must be promptly reported and escalated Overloading and inappropriate disposal of items in macerators must stop. A Datix report is required if this occurs. Commodes must be cleaned and disinfected between each patient. Patients should not have urinary catheters unless there is a clear indication for this. Patients with long term catheters or discharged with a urinary catheter must have an up to date catheter passport. Extract from Health Protection England Advice 12 ENSURE THAT: 1. All staff fully understand 2. Scrupulous IP&C practices are isolation procedures and adhere emphasised as being to standard precautions as a particularly important when norm including: using and caring for devices / equipment such as: Hand hygiene Personal protective equipment Aseptic technique Laundry management Safe use of sharps Waste disposal (especially faeces) Intravenous / peripheral line Central venous catheter line Urinary catheter Ventilators Renal dialysis equipment Enteral feeding equipment Colostomy or ileostomy Any re-useable diagnostic equipment (Annex 3) NOTE: Loose stools or diarrhoea (for any reason) increase the risk of spread of the bacteria from the gut therefore: Observe strict IP&C measures Provide assistance to patients where effective hand hygiene is in doubt 13. Cleaning environment: and decontamination of equipment and the Whilst these bacteria can be carried on hands and gloves and equipment and contaminate surfaces they are not as resistant to cleaning and disinfection as Clostridium difficile. The disinfectants which we have available e.g. Acticlor plus, disinfectant based wipes, e.g. Chlorclean,Terminal Cleaning and disinfection should also be followed by Hydrogen Peroxide Vapour (HPV) Visible soiling of surfaces or equipment must be removed first using a neutral detergent solution or detergent wipe as appropriate before a disinfectant is used. Dedicated single patient or single use equipment is preferable, and should always be considered when treating a CPE positive patient. For other contact patient equipment which cannot be decontaminated for example endoscopes, attached cameras and other equipment which 13 cannot be steam cleaned, should be protected using a single use covering (sleeve) and thoroughly disinfected between patients once the covering has been removed. Mattresses are of particular importance and conventional mattress covers should be cleaned and disinfected. Dynamic mattresses should be disassembled cleaned and disinfected and then sorted within the appropriate bagging which is supplied, whilst awaiting collection from the specialist mattress provider. Privacy curtains should be removed and laundered or should be single use. Unused wrapped single use items in the patient’s immediate vicinity (that may have become contaminated by hand contact) should be discarded. 14. Treatment & Therapies: Those patients, who do not have diarrhoea, can leave their isolation room to receive treatment or therapies. Following treatment or therapy session, used equipment must be cleaned as stated in section 9. Gloves and aprons must be worn by staff and hand hygiene performed following 15. Removing patients from isolation: Patients may be removed from isolation, following three consecutive negative screens 48 hours (two days apart). Please refer to (Annex 1 ) of the pathway to record results and ensure results are documented within patient’s case notes. Patients should be closely monitored as individuals following negative screenings can revert to a positive state, especially after a course of antibiotics. Decontamination is most crucial following a patient leaving a specific area – for example from an isolation room or a bed space. This will need co-ordination between the domestic, healthcare assistants, nurses and other specialities as appropriate. 16. References 14 Carbapenemase-producing Enterobacteriaceae: early detection, management and control toolkit for acute trusts.1ST Published 19th June 2014 Public Health England. BNF 65(British National Formulary) March-September 2013-bnf.org Communicable Disease Control and Health Protection handbook-third edition 2012.Hawker J, Begg N- Wiley Blackwell 15 Carbapenemase-producing Enterobacteriaceae (CPE) Patient Pathway Management ANNEX 1 Place patient sticker Place patient sticker To be used for both suspected and confirmed cases of CPE. here Immediate actions to be taken: Isolate the patient immediately with enhanced precautions in place Ensure that en-suite facilities or dedicated commode are available Notify the Infection Control Nurses on 295-3036 If sepsis is suspected ward bleed GP to contact Medical Microbiology for antibiotic prescribing advice Checklist for patient confirmed or suspected of being CPE positive Date 1 Isolate patient in a side room 2 En-suite toilet facilities provided 3 If no en-suite toilet facilities are available a dedicated toilet facility for the patient has been identified 4 Enhanced precaution signage displayed 5 Explain CPE to patient and provide information leaflet. 6 Explain how infection is spread and precautions to relatives. 7 All staff in contact with the patient to be informed of precautions required. 8 Dedicated single patient or single use equipment has been provided to include-: BP cuff Stethoscope Thermometer 9 All appropriate PPE available outside the patient’s room to include gloves, aprons, and long sleeved gowns. 10 Bristol Stool Chart in place for early detection of diarrhoea 11 Enhanced environmental cleans in place & discussed with cleaning contractors the use of chloride based detergent 1000 ppm. Sign Comments If the patient has a previously screened positive for CPE Obtain a rectal swab within 24 hours of admission Request specimens through ICE /SIGMA Document specimens as collected/sent in Section 2 Please ensure CPE is clearly documented on request form CPE Specimen results from this admission (all specimens obtained): Date Collected Site Result Signature NB: Please ensure that enhanced precautions remain in place even if negative results are obtained. Section 3a: Transfer department for investigations: Date Investigation Department informed of patients CPE status? Y/N Patient placed at end of investigation list if practicable Y/N Therapies Section 3b: Transfer to another ward (to be completed by receiving ward): Date 1 Isolate patient in a side room 2 En-suite toilet facilities provided 3 If no en-suite toilet facilities are available a dedicated toilet facility for the patient has been identified 4 Enhanced precaution signage displayed 5 All staff in contact with the patient to be informed of precautions required 6 Dedicated single patient or single use equipment has been provided to include -: BP cuff Stethoscope Thermometer 7 All appropriate PPE available outside the patients room to include gloves, aprons, and long sleeved gowns 8 Bristol Stool Chart in place for early detection of diarrhoea 9 Enhanced environmental cleans in place Signature Comment Signature Section 4: Discharge or Transfer to another health care setting: Date Signature Date Signature Inform receiving hospital, hospice, nursing home etc. (if appropriate) Ensure all written communication includes the patients infection risk Inform Infection Control Team Patient toilets cleaned as appropriate Side room and communal equipment cleaned appropriately Section 5: Discharge to Home: Inform Infection Prevention Control Team Ensure patient and family are given CPE leaflet Ensure patient is given CPE card Infection Prevention Control Team ensure GP is informed ANNEX 2 GP Letter for Discharge of CPE positive patient- North West Version, May 2014 TRUST DETAILS Date General Practice Dear Dr Carbapenemase- producing Enterobacteriaceae Infection or Colonisation NAME DOB ADDRESS NHS Number (Sticker, automated data entry or by hand) The above patient had a carbapenemase- producing Enterobacteriaceae (CPE) identified from a screening /clinical [Delete as appropriate] sample on [Date]. CPE are an emerging healthcare associated infection, and have caused a number of significant outbreaks across the North West. CPE are carried in the faeces and there is currently no treatment to eradicate carriage. Please list carbapenemase- producing Enterobacteriaceae infection/colonisation as an active significant problem on your records for this patient so that it appears on any referral letter, especially for admission. We suggest using read code A3BA [Organism resistant to multiple antibiotics], and adding carbapenemase- producing Enterobacteriaceae in free text. If this patient presents with an infection requiring antibiotics, please contact your local microbiologist to discuss sample collection and antibiotic choice. In your surgery, standard infection control practices will minimise the spread of this faecal organism. Standard practice should be rigorously implemented but no additional infection control precautions are required. As part of a patient information package, this patient has been given a CPE card and they have been asked to show this card to staff when visiting any health or social care setting. A copy of the patient information leaflet is attached. Further information on CPE is available on the Public Health England website, http://www.hpa.org.uk/Publications/InfectiousDiseases/AntimicrobialAnd HealthcareAssociatedInfections/1312Toolkitforcarbapenementero/ If you or your team have any concerns or queries regarding infection control for CPE, please contact your local community infection, prevention and control team on XXXX Yours sincerely ANNEX 3 Carbapenemase-producing Enterobacteriaceae (CPE) Information Leaflet for Patients in North West England What are CPE? CPE stands for carbapenemase-producing Enterobacteriaceae. Enterobacteriaceae are bacteria (germs) that usually live harmlessly in the gut of humans. This is called ‘colonisation’ (a person is said to be a ‘carrier’). However, if the bacteria get into the wrong place, such as the bladder or bloodstream they can cause infection. Carbapenems are one of the most powerful types of antibiotics. Carbapenemases are enzymes (chemicals), made by some strains of these bacteria, which allow them to destroy carbapenem antibiotics and so the bacteria are said to be resistant to most antibiotics. Why does carbapenem resistance matter? Carbapenem antibiotics can only be given in hospital directly into the bloodstream. Until now, doctors have relied on them to successfully treat certain ‘difficult’ infections when other antibiotics have failed to do so. In a hospital, where there are many vulnerable patients, spread of resistant bacteria can cause problems. Does carriage of CPE need to be treated? If a person is a carrier of CPE, they do not need to be treated. However, if the bacteria have caused an infection then antibiotics will be required. Your doctor or nurse will be able to tell you if are a carrier or a case (infected). How did I pick up CPE? Ask your doctor or nurse to explain this to you in more detail. As mentioned above, sometimes the bacteria can be found, living harmlessly, in the gut of humans and so it can be difficult to say when or where you picked it up. However, there is an increased chance of picking up these bacteria if you have been a patient in a hospital abroad or in a UK hospital that has had patients carrying the bacteria, or if you have been in contact with a carrier elsewhere. How will I be cared for whilst in hospital? You will be assessed by healthcare staff as to whether you need to be nursed in a single room or in a bay with others. You may be asked to provide a number of samples / swabs depending on your length of stay, to check if you are still carrying the bacteria. These will probably be taken on a weekly basis. Samples and swab sites may include where the tube for your drip (if you have one) enters the skin, a rectal swab [a sample taken by inserting a swab briefly just inside your rectum (bottom)], and / or a faecal (poo) sample. You will normally be informed of the results within two to three days. How can the spread of CPE be prevented? Healthcare workers should wash their hands regularly with soap and water or alcohol gel. They will use gloves and aprons (occasionally gowns) when caring for you. The most important measure for you to take is to wash your hands thoroughly with soap and water especially after going to the toilet. You should avoid touching medical devices (if you have any) such as your urinary catheter tube and your intravenous drip, particularly at the point where it is inserted into the body or skin. Visitors will be asked to wash their hands on entering and leaving the room and may be asked to wear an apron / gloves if they are helping you with personal care. What about when I go home? As soon as your general condition allows and your doctors consider you are ready for discharge, you can go home. Remember that even though you may not be showing signs of infection, you may still be carrying the CPE. It is important to inform a member of health or social care staff when attending such settings, that CPE has been identified previously. You will receive a patient card on CPE from your care staff for you to carry and present to staff if you need to attend a health or social care setting. This will ensure that you are looked after appropriately. If you visit the GP surgery after discharge, please tell your GP that you have been diagnosed with CPE. Good personal hygiene is important; this will help to protect you from infection and reduce the risk of spread to others. Hand hygiene is essential using soap and warm running water. You should wash your hands before preparing food or eating and directly after using the toilet. If you have personal care at home, please contact your community infection control team for further advice. Where can I find more information? If you would like any further information please speak to a member of staff, who may also contact the Infection Prevention and Control Team for you. The Public Health England website is another source of information: www.hpa.org.uk/Topics/InfectiousDiseases/InfectionsAZ/CarbapenemRe sistance/ Patient held card – North West, April 2014 c : :