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Team Members Regulation of microtubule dynamics and functions Carsten Janke CNRS Research Director TEAM JANKE Team Leader [email protected] Tel: +33 1 69 86 31 27 1994: Diploma in Biochemistry, University of Leipzig, Germany 1998: PhD in Biochemistry-Neurochemistry, University of Leipzig, Germany 1998-1999: Postdoc in biophysics, CBM, CNRS Orléans, France 1999-2002: Postdoc in yeast cell biology, Beatson Institut for Cancer Research, Glasgow, UK 2002-2005: Postdoc & staff scientist (CR1), CRBM, CNRS Montpellier, France 2005-2010: Junior group leader, CRBM, CNRS Montpellier, France 2009: DR2 CNRS 2010 - today: Senior group leader at the Institut Curie, Orsay, France 2013: DR1 CNRS Scientific achievements and prices 2008 2014 EMBO Young Investigator EMBO member Experience with network coordination and grant applications Coordinator of 8 research grants (HFSP, ANR, INCA, …). Co-funder and scientific coordinator of a European Initial Training Network (ITN) 19 successful grant applications 20 successful applications for fellowships in the Janke team. Implications in the scientific community Established a large number of scientific collaborations Organizer of an EMBO conference series (2010, 2012, 2016), and an EMBL/EMBO symposium (2016) on Microtubules Organizer of a French-Indian Cytoskeleton workshop (2015) INSTITUT CURIE, 20 rue d’Ulm, 75248 Paris Cedex 05, France | 1 Team Members Regulation of microtubule dynamics and functions Reviewer for many grant agencies and scientific journals Member for evaluation commissions, scientific advisory boards, editorial board of J Cell Science Key publications Year of publication 2017 Akendengue L., Trepout S., Grana M., Voegele A., Janke C., Raynal B., Chenal A., Marco S., Wehenkel A.M. (2017 Mar 30) Bacterial kinesin light chain (Bklc) links the Btub cytoskeleton to membranes SCIENTIFIC REPORTS : 7 : DOI : 10.1038/srep45668 Year of publication 2014 Olivia Tort, Sebastián Tanco, Cecilia Rocha, Ivan Bièche, Cecilia Seixas, Christophe Bosc, Annie Andrieux, Marie-Jo Moutin, Francesc Xavier Avilés, Julia Lorenzo, Carsten Janke (2014 Oct 1) The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids. Molecular biology of the cell : 3017-27 : DOI : 10.1091/mbc.E14-06-1072 Cecilia Rocha, Laura Papon, Wulfran Cacheux, Patricia Marques Sousa, Valeria Lascano, Olivia Tort, Tiziana Giordano, Sophie Vacher, Benedicte Lemmers, Pascale Mariani, Didier Meseure, Jan Paul Medema, Ivan Bièche, Michael Hahne, Carsten Janke (2014 Oct 1) Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon. The EMBO journal : 2247-60 : DOI : 10.15252/embj.201488466 Year of publication 2013 Montserrat Bosch Grau, Gloria Gonzalez Curto, Cecilia Rocha, Maria M Magiera, Patricia Marques Sousa, Tiziana Giordano, Nathalie Spassky, Carsten Janke (2013 Aug 5) Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia. The Journal of cell biology : 441-51 : DOI : 10.1083/jcb.201305041 Year of publication 2010 Krzysztof Rogowski, Juliette van Dijk, Maria M Magiera, Christophe Bosc, Jean-Christophe INSTITUT CURIE, 20 rue d’Ulm, 75248 Paris Cedex 05, France | 2 Team Members Regulation of microtubule dynamics and functions Deloulme, Anouk Bosson, Leticia Peris, Nicholas D Gold, Benjamin Lacroix, Montserrat Bosch Grau, Nicole Bec, Christian Larroque, Solange Desagher, Max Holzer, Annie Andrieux, Marie-Jo Moutin, Carsten Janke (2010 Nov 12) A family of protein-deglutamylating enzymes associated with neurodegeneration. Cell : 564-78 : DOI : 10.1016/j.cell.2010.10.014 Benjamin Lacroix, Juliette van Dijk, Nicholas D Gold, Julien Guizetti, Gudrun Aldrian-Herrada, Krzysztof Rogowski, Daniel W Gerlich, Carsten Janke (2010 Jun 14) Tubulin polyglutamylation stimulates spastin-mediated microtubule severing. The Journal of cell biology : 945-54 : DOI : 10.1083/jcb.201001024 Year of publication 2009 Krzysztof Rogowski, François Juge, Juliette van Dijk, Dorota Wloga, Jean-Marc Strub, Nicolette Levilliers, Daniel Thomas, Marie-Hélène Bré, Alain Van Dorsselaer, Jacek Gaertig, Carsten Janke (2009 Jun 12) Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Cell : 1076-87 : DOI : 10.1016/j.cell.2009.05.020 Year of publication 2007 Juliette van Dijk, Krzysztof Rogowski, Julie Miro, Benjamin Lacroix, Bernard Eddé, Carsten Janke (2007 May 11) A targeted multienzyme mechanism for selective microtubule polyglutamylation. Molecular cell : 437-48 : DOI : 10.1016/j.molcel.2007.04.012 Year of publication 2005 Carsten Janke, Krzysztof Rogowski, Dorota Wloga, Catherine Regnard, Andrey V Kajava, JeanMarc Strub, Nevzat Temurak, Juliette van Dijk, Dominique Boucher, Alain van Dorsselaer, Swati Suryavanshi, Jacek Gaertig, Bernard Eddé (2005 Jun 17) Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Science (New York, N.Y.) : 1758-62 : DOI : 10.1126/science.1113010 INSTITUT CURIE, 20 rue d’Ulm, 75248 Paris Cedex 05, France | 3