Download MITOMYCIN C (CONTAINS 2MG MITOMYCIN C AND 48MG

MITOMYCIN C (CONTAINS 2MG MITOMYCIN C AND 48MG SODIUM
CHLORIDE)
Synonyms: Ametycine.
Tarja: preta (cancerígeno, produto extremamente tóxico)
Descarte dos resíduos do composto: soluções aquosas diluídas: coleta separada. Sólidos:
incineração.
SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Appearance: blue-violet.
Warning! Harmful if swallowed. May cause adverse reproductive
effects based upon animal studies. May cause respiratory and
digestive tract irritation. May cause eye and skin irritation. May
cause cancer based on animal studies. Potential cancer hazard.
Target Organs: Liver, bone marrow.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion::
Harmful if swallowed. May cause liver damage. May cause digestive
tract disturbances. May cause bone marrow depression.
Inhalation::
May cause respiratory tract irritation. May cause effects similar to
those described for Ingestion:. May cause pulmonary fibrosis and
permanent damage.
Chronic:
May cause cancer according to animal studies. Chronic exposure may
cause liver damage. Adverse reproductive effects have been reported
in animals. Potential cancer hazard.
SECTION 4 - FIRST AID MEASURES ****
Eyes:
Flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of soap and water for at
least 15 minutes while removing contaminated Clothing and shoes. Wash
Clothing before reuse.
Ingestion::
Do NOT induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Get medical aid.
Inhalation::
Remove from exposure to fresh air immediately. If not breathing,
give artificial respiration. If breathing is difficult, give oxygen.
Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Treat symptomatically and supportively.
SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion.
Non-combustible, substance itself does not burn but may decompose
upon heating to produce irritating, corrosive and/or toxic fumes.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or
alcohol-resistant foam. Substance is noncombustible; use agent most
appropriate to extinguish surrounding fire.
Autoignition Temperature:Not applicable.
Flash Point:
Not applicable.
Explosion Limits, lower:Not available.
Explosion Limits, upper:Not available.
NFPA Rating: (estimated) Health: 2; Flammability: 0; Reactivity: 0
SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective
Equipment section. Sweep up, then place into a suitable container for
disposal. Avoid generating dusty conditions. Provide ventilation.
SECTION 7 - HANDLING: and STORAGE ****
Handling::
Wash thoroughly after Handling:. Remove contaminated Clothing and
wash before reuse. Use only in a well-ventilated area. Minimize dust
generation and accumulation. Do not get in eyes, on skin, or on
Clothing. Keep container tightly closed. Do not ingest or inhale.
Storage :
Do not store in direct sunlight. Keep container closed when not in
use. Store in a cool, dry, well-ventilated area away from
incompatible substances. Hormones and antibiotics room. Store below
40&C.
SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate general or
local exhaust ventilation to keep airborne concentrations below the
permissible exposure limits.
Personal Protective Equipment
Eyes:
Wear safety glasses and chemical goggles if splashing
is possible.
Skin:
Wear appropriate protective gloves and Clothing to
prevent skin exposure.
Clothing:
Wear appropriate protective Clothing to minimize
contact with skin.
Respirators :
A NIOSH/MSHA approved or European Standard EN 149 air
purifying respirator with an organic vapor cartridge
or canister may be permissible under certain
circumstances where airborne concentrations are
expected.
SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State:
Crystalline powder
Appearance:
blue-violet
Freezing/Melting Point: > 360 deg C
Decomposition Temperature:
Solubility in water:
soluble
Molecular Formula:
C15H18N4O5
Molecular Weight:
334.32
SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, light, dust generation, excess heat,
temperatures above 40&C.
Incompatibilities with Other Materials:
Strong oxidizing agents - strong acids - strong bases.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.
SECTION 11 - TOXICOLOGICAL INFORMATION ****
LD50/LC50:
CAS# 50-07-7: Oral, mouse: LD50 = 23 mg/kg; Oral, rat: LD50 = 30
mg/kg.
CAS# 7647-14-5: Draize test, rabbit, eye: 100 mg Mild; Draize test,
rabbit, eye: 100 mg/24H Moderate; Draize test, rabbit, eye: 10 mg
Moderate; Draize test, rabbit, Skin: 50 mg/24H Mild; Draize test,
Skin:
Inhalation:
rabbit, Skin: 500 mg/24H Mild; Inhalation:, rat: LC50 = >42 gm/m3/1H;
Oral, mouse: LD50 = 4 gm/kg; Oral, rat: LD50 = 3 gm/kg; Skin, rabbit:
LD50 = >10 gm/kg.
Carcinogenicity:
Mitomycin C California: carcinogen; initial date 4/1/88
OSHA: Possible Select carcinogen
IARC: Group 2B carcinogen
Sodium chloride Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Epidemiology:
IARC Group 2B: Proven animal carcinogenic substance of potential
relevance to humans. IARC Group 2B: No data available on human
carcinogenicity, however sufficient evidence of carcinogenicity in
animals. Experimental reproductive effects have been reported.
Teratogenicity:
No information found.
Reproductive Effects:
Reproductive effects have occurred in experimental animals.
Neurotoxicity:
No information found.
Mutagenicity:
Mutagenic effects have occurred in experimental animals.
Other Studies:
See actual entry in RTECS for complete information.