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MITOMYCIN C (CONTAINS 2MG MITOMYCIN C AND 48MG SODIUM CHLORIDE) Synonyms: Ametycine. Tarja: preta (cancerígeno, produto extremamente tóxico) Descarte dos resíduos do composto: soluções aquosas diluídas: coleta separada. Sólidos: incineração. SECTION 3 - HAZARDS IDENTIFICATION **** EMERGENCY OVERVIEW Appearance: blue-violet. Warning! Harmful if swallowed. May cause adverse reproductive effects based upon animal studies. May cause respiratory and digestive tract irritation. May cause eye and skin irritation. May cause cancer based on animal studies. Potential cancer hazard. Target Organs: Liver, bone marrow. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion:: Harmful if swallowed. May cause liver damage. May cause digestive tract disturbances. May cause bone marrow depression. Inhalation:: May cause respiratory tract irritation. May cause effects similar to those described for Ingestion:. May cause pulmonary fibrosis and permanent damage. Chronic: May cause cancer according to animal studies. Chronic exposure may cause liver damage. Adverse reproductive effects have been reported in animals. Potential cancer hazard. SECTION 4 - FIRST AID MEASURES **** Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated Clothing and shoes. Wash Clothing before reuse. Ingestion:: Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation:: Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. Notes to Physician: Treat symptomatically and supportively. SECTION 5 - FIRE FIGHTING MEASURES **** General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Non-combustible, substance itself does not burn but may decompose upon heating to produce irritating, corrosive and/or toxic fumes. Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Substance is noncombustible; use agent most appropriate to extinguish surrounding fire. Autoignition Temperature:Not applicable. Flash Point: Not applicable. Explosion Limits, lower:Not available. Explosion Limits, upper:Not available. NFPA Rating: (estimated) Health: 2; Flammability: 0; Reactivity: 0 SECTION 6 - ACCIDENTAL RELEASE MEASURES **** General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation. SECTION 7 - HANDLING: and STORAGE **** Handling:: Wash thoroughly after Handling:. Remove contaminated Clothing and wash before reuse. Use only in a well-ventilated area. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on Clothing. Keep container tightly closed. Do not ingest or inhale. Storage : Do not store in direct sunlight. Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Hormones and antibiotics room. Store below 40&C. SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION **** Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Personal Protective Equipment Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves and Clothing to prevent skin exposure. Clothing: Wear appropriate protective Clothing to minimize contact with skin. Respirators : A NIOSH/MSHA approved or European Standard EN 149 air purifying respirator with an organic vapor cartridge or canister may be permissible under certain circumstances where airborne concentrations are expected. SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES **** Physical State: Crystalline powder Appearance: blue-violet Freezing/Melting Point: > 360 deg C Decomposition Temperature: Solubility in water: soluble Molecular Formula: C15H18N4O5 Molecular Weight: 334.32 SECTION 10 - STABILITY AND REACTIVITY **** Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, light, dust generation, excess heat, temperatures above 40&C. Incompatibilities with Other Materials: Strong oxidizing agents - strong acids - strong bases. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen. Hazardous Polymerization: Has not been reported. SECTION 11 - TOXICOLOGICAL INFORMATION **** LD50/LC50: CAS# 50-07-7: Oral, mouse: LD50 = 23 mg/kg; Oral, rat: LD50 = 30 mg/kg. CAS# 7647-14-5: Draize test, rabbit, eye: 100 mg Mild; Draize test, rabbit, eye: 100 mg/24H Moderate; Draize test, rabbit, eye: 10 mg Moderate; Draize test, rabbit, Skin: 50 mg/24H Mild; Draize test, Skin: Inhalation: rabbit, Skin: 500 mg/24H Mild; Inhalation:, rat: LC50 = >42 gm/m3/1H; Oral, mouse: LD50 = 4 gm/kg; Oral, rat: LD50 = 3 gm/kg; Skin, rabbit: LD50 = >10 gm/kg. Carcinogenicity: Mitomycin C California: carcinogen; initial date 4/1/88 OSHA: Possible Select carcinogen IARC: Group 2B carcinogen Sodium chloride Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. Epidemiology: IARC Group 2B: Proven animal carcinogenic substance of potential relevance to humans. IARC Group 2B: No data available on human carcinogenicity, however sufficient evidence of carcinogenicity in animals. Experimental reproductive effects have been reported. Teratogenicity: No information found. Reproductive Effects: Reproductive effects have occurred in experimental animals. Neurotoxicity: No information found. Mutagenicity: Mutagenic effects have occurred in experimental animals. Other Studies: See actual entry in RTECS for complete information.