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BIOGRAPHICAL SKETCH
NAME
POSITION TITLE
Eric Wooten
Post-Doctoral Research Fellow
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Austin College
Baylor College of Medicine
DEGREE
(if applicable)
YEAR(s)
B.A.
1991
Ph.D.
2003
FIELD OF STUDY
Biology
Molecular/Cellular
Biology
A. Positions and Honors:
Positions
1993-1996
Research Assistant, University of Texas Health Science Center at San Antonio, Department of
Pathology, Peter O’Connell laboratory
 STS-based contig mapping of chromosomes 3 and 8
1996-2003
Graduate Student, Departments of Molecular Medicine (UT Health Science Center San Antonio)
and Molecular and Cellular Biology (Baylor College of Medicine), Peter O’Connell laboratory.
 Genome-wide LOH analysis of patients with sporadic gliomas
 Linkage analysis of families with predisposition to multiple severe cancers at loci from LOH
study
 Array-based analysis of expression patterns relative to drug resistance in core biopsies from
locally advanced breast cancers
2004-2007
Postdoctoral Fellow, Department of Genetics and Genomics, Boston University School of
Medicine, Michael F. Christman laboratory
 Direct observation of histone modifications proximal to random and targeted DNA double
strand breaks
 Prospective whole genome association studies employing ~100,000 single nucleotide
polymorphisms and multiply measured phenotype data from the Framingham Heart Study
population
2007-Present Postdoctoral Research Fellow, Center for Translational Genomics, Molecular Cardiology
Research Institute, Tufts Medical Center
 Design of targeted, candidate-based genotyping studies using cosmopolitan tagging
approach
 Developing tools to assist in merging local and public databases into coherent biological
networks for analysis with emphasis on existing resources in expression and genotyping
array data
 Developing automated SNP-discovery pipeline through computational sequence analysis
and comparison
 Utilizing BioMart and other tools to link numerous existing databases and data structures
into a unitary, locally accessible tool with automated linking to public servers and databases.
Honors
2003
The Lancet, Nomination for Paper of the Year 362:2101-2103(2003)
B. Publications:
Peer-Reviewed Articles
1. A study of loss of heterozygosity at 70 loci in anaplastic astrocytoma and glioblastoma multiforme with
implications for tumor evolution; Eric C. Wooten, Dan Fults, Ravindrannath Duggiriala, Kenneth Williams,
Athanassias P. Kyritsis, Melissa Bondy, Victor A. Levin, and Peter O’Connell; Neuro-Oncology: 1, 169-176
(1999)
2. Coordinated Up-Regulation of Oxidative Pathways and Down-Regulation of Lipid Biosynthesis underlie
Obesity Resistance in Perilipin Knockout Mice: A Microarray Gene Expression Profile; Castro-Chavez F,
Yechoor VK, Saha PK, Martinez-Botas J, Wooten EC, Sharma S, O'Connell P, Taegtmeyer H, Chan L.;
Diabetes: 52(11) 2666-2674 (2003)
3. Gene expression profiling predicts therapeutic response to docetaxel (Taxotere™) in breast cancer
patients; Jenny C. Chang* and Eric C. Wooten*, Anna Tsimelzon, Susan G Hilsenbeck, M Carolina
Gutierrez, Richard Elledge, Syed Mohsin, C Kent Osborne, Gary Chamness, D Craig Allred, and Peter
O’Connell; The Lancet 362 (9381): 362-9 (2003), (*co-first authors)
4. Patterns of resistance and incomplete response to docetaxel by gene expression profiling in breast cancer
patients; Chang JC*and Wooten EC*, Tsimelzon A, Hilsenbeck SG, Gutierrez MC, Tham YL, Kalidas M,
Elledge R, Mohsin S, Osborne CK, Chamness GC, Allred DC, Lewis MT, Wong H, O'Connell P; Journal of
Clinical Oncology 23(6):1169-77 (2005); (*co-first authors)
5. Increased FOG-2 in failing myocardium disrupts thyroid hormone-dependent SERCA2 gene transcription.
Rouf R, Greytak S, Wooten EC, Wu J, Boltax J, Picard M, Svensson EC, Dillmann WH, Patten RD,
Huggins GS; Circulation Research 103(5):493-501 (2009)
6. Application of Gene Network Analysis Techniques Identifies AXIN1/PDIA2 and Endoglin Haplotypes
Associated with Bicuspid Aortic Valve. Eric C Wooten, Lakshmanan K Iyer, Maria Claudia Montefusco,
Alyson Kelley Hedgepeth, Douglas D Payne, Navin K Kapur, David E Housman, Michael E Mendelsohn,
and Gordon S Huggins; PLoS ONE 5(1): e8830 (2010). doi:10.1371/journal.pone.0008830
C. Research Support
Ongoing Research Support
0826005D (PI: Wooten, Sponsor: Huggins)
07/01/08 – 06/30/10
American Heart Association
“Bicuspid Aortic Valve: A Genomic Approach”
The major goal is to analyze the underlying genetic causes of Bicuspid Aortic Valve (BAV) within a limited
cohort. Employs in silico prioritization of regions and individual probes to maximize information content and
reduce overall multiple-testing load to level compatible with sample availability. This approach should elucidate
both the genetic cause(s) of BAV and provide a methodology that is readily and widely applicable to many
other disorders with clear genetic elements in the setting of relatively low-frequency heritable disease.
Completed Research Support
0555877T (PI: Huggins)
07/01/05 – 06/30/08
American Heart Association/Grant-in-Aid
“FOG-2 Regulation of Cardiac Thyroid Hormone-Dependent Gene Expression”
The major goals are to analyze the physical interaction between FOG-2 and the thyroid hormone receptors.
Determine the effect of FOG-2 on thyroid hormone-dependent gene expression. Study the effects of FOG-2
expression on cardiomyocyte expression of thyroid hormone dependent genes, including SERCA2.
T32 HL69770 (PI: Mendelsohn)
08/01/03 – 06/30/08
NIH/NHLBI
"Training Program in Cardiovascular Research"
The purpose of this Program is to train postdoctoral MD and/or PhD fellows in either (a) basic cellular and
molecular research in the cardiovascular system; or (b) translational cardiovascular research.
P01 HL077378A (PI: Mendelsohn)
06/01/07 – 05/31/08
NIH/NHLBI
“Molecular Mechanisms of Vascular Relaxation”
Project 1 - “Genetics of Vasorelaxation and Cardiovascular Responses”
The major goals are to analyze vasorelaxation, intima-media thickness and hypertension in association with
Genetic variants associated with reduced myosin light chain phosphatase activity; Genetic variants associated
with increased myosin light chain phosphatase activity; Genetic variants associated with abnormal BKCa
channel function. Grant is in no-cost extension until 07/31/10.