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Radiation Oncology March 2014 Volume 1, Issue 3 TrueBeamTM STx Now at USC O n January 13, 2014, the USC Department of Radiation Oncology treated our first patient with our new TrueBeamTM STx linear accelerator. We are absolutely thrilled to now have this powerful treatment device available for the care of our patients. Besides serving as an excellent tool for standard radiotherapy treatments, the STx allows us to deliver stereotactic radiosurgery (SRS) for treatments of the brain, and stereotactic body radiotherapy Chair’s Corner I am excited to share with you some terrific advancements happening in our continued transformation of the Keck School of Medicine (KSOM) of USC Department of Radiation Eric L. Chang, M.D. Oncology. As we continue to Professor and Chair USC Department of see double-digit growth in our Radiation Oncology patient volumes, we are hard at work to further bolster our ability to deliver on our patient care, education and research missions. On the patient care front, we are thrilled to begin utilizing our new TrueBeamTM STx linear accelerator, and newly renovated HDR brachytherapy suite, both detailed herein. Having these tools available, combined with our Gamma Knife®, CyberKnife® and TrilogyTM Linear Accelerator, provides USC oncologists and referring physicians in the community unparalleled access to cutting-edge treatment modalities that can be best tailored to the unique treatment needs of their patients. (SBRT) also known as stereotactic ablative radiotherapy (SABR) for treatments of the spine and the rest of the body with unprecedented speed and accuracy. A complete radiosurgery treatment can be performed in a shortened amount of time on the STx, leaving less time for tumor and patient movement during dose delivery. We also achieved a major milestone in our residency program, receiving the maximum allowed accreditation offered by the Accreditation Council for Graduate Medical Education based on a July 2013 site visit. The TrueBeamTM STx’s enhanced real-time imaging tools allow our multidisciplinary oncology team to see the tumor they are about to treat and visualize it throughout the course of treatment. Since beam delivery is synchronized with tumor motion during respiration, complex cases such as those in the lung, upper abdomen and the breast can be treated while minimizing the dose to the surrounding healthy tissue and critical organs. Along with the TrueBeamTM STx, we are implementing Brainlab iPlan© treatment planning and ExacTrac© room-based , real-time X-ray imaging technology, which can be performed during actual treatment delivery. Combining the flexibility the TrueBeamTM STx offers with our Varian TrilogyTM Linear Accelerator, our CyberKnife®, our GammaKnife® and our new HDR brachytherapy suite, we now offer oncologists the ability to choose the best treatment platform for each clinical scenario. For referrals, call (323) 865-3050 For more information visit cancer.KeckMedicine.org/referradonc Radiation Oncology Breast Cancer Symposium O n January 25, 2014, the Department of Radiation Oncology and USC Office of Continuing Medical Education held a tremendously successful, first-of-its-kind, USC Radiation Oncology Breast Cancer Symposium. The program reviewed the current state-of-the-art in breast cancer management, highlighting key components of multidisciplinary treatment, including surgery, medical oncology, radiation oncology, and radiology. Keynote speakers included Jay Harris, MD, professor and chief, Department of Radiation Oncology, Harvard Medical School, Dana-Farber Cancer Institute, Brigham and Women’s Hospital, as well as Lori Pierce, MD, vice provost and professor of Radiation Oncology, University of Michigan School of Medicine. The symposium involved a large audience in the Aresty Auditorium at the USC Norris Comprehensive Cancer Center and feedback on the quality of the presentations has been very positive. We look forward to hosting similar events in the future. Physician Faculty Eric L. Chang, MD CNS, Gamma Knife, CyberKnife Leslie Ballas, MD GU, Lymphoma, Melanoma Eugene Chung, MD, PhD, JD Thoracic, Breast Richard L.S. Jennelle, MD Residency Director, Head & Neck and other specialties Michael Senikowich, MD Gyn, brachy and other specialties, LAC+USC based Suisui Song, MD Gyn, GI, Sarcoma Nicholas Trakul, MD, PhD Head & Neck, Thoracic, SBRT, CNS Physics Faculty Almon Shiu, PhD Vice Chair, Chief of Physics Hyman Bernstein, PhD LAC+USC Residency Full Accreditation Guoqiang Cui, PhD USC Norris Cancer Hospital SC Radiation Oncology achieved a major milestone in the continued transformation of our residency training program – receiving 10–year accreditation by the ACGME in their NEXT Accreditation System, the maximum permited. Jonathan Kin Ha, PhD LAC+USC U Training the next generation of radiation oncologists is a major component of our tripartite mission. We strive to provide the best training environment for our residents, preparing them for outstanding careers in academic or community practice. Receiving this accreditation is a testament to the considerable work we have done to enhance the program over the past two years. A special thank you goes out to Richard Jennelle, MD, our Residency Program director, for his unwavering dedication to bettering the program. For referrals, call (323) 865-3050 For more information visit cancer.KeckMedicine.org/referradonc Arthur Olch, PhD CHLA Sue Zhou, MS USC Norris Cancer Hospital Audrey Zhuang, PhD LAC+USC Radiobiology Faculty Colin Hill, PhD Charles Gomer, PhD Promotion of Rosemary Sambrano, RTT W e are pleased to announce the promotion of Rosemary Sambrano, RTT, to supervising radiation therapy technologist in the Department of Radiation Oncology at LAC+USC Medical Center. Ms. Sambrano has been with the LAC+USC Medical Center for 16 years, most recently serving as acting supervising radiation therapy technologist. Ms. Sambrano brings a wealth of experience to her new permanent role. She is knowledgeable, highly skilled, reliable, and a caring professional. Please join us in congratulating Ms. Sambrano on her promotion. HDR Brachytherapy W e are excited to announce that the USC Norris Comprehensive Cancer Center is about to begin offering highdose-rate (HDR) brachytherapy as a treatment option for patients. We have completed renovations on our brachytherapy vault, and we now have a new Varian Varisource HDR afterloader unit onsite for the care of our patients. Unlike low-dose-rate (LDR) brachytherapy where seeds are implanted and left in the patient, the HDR procedure involves attaching or embedding an intense source of radiation into a temporary applicator and then delivering that Ir-192 radioactive source via a computer-controlled afterloader, letting it dwell temporarily in the tumor for three to 10 minutes before it is retracted back into the afterloader. For some types of tumors, treating the patient with HDR brachytherapy allows a patient to be seen in five to 10 visits, rather than the 30-45 visits required with typical radiation. Initial uses of our system will be for breast, GU and gynecologic oncology patients, with plans to expand the applications to sarcoma, skin cancer, recurrent head and neck cancer, endobronchial lesions in lung cancer and endoluminal cases of esophageal cancer and bile duct cancer. Recent Publications 1. G hia AJ, Chang EL, Allen PK, Mahajan A, Penas-Prado M, McCutcheon IE, Brown PD. Intracranial hemangiopericytoma: patterns of failure and the role of radiation therapy. Neurosurgery. 2013 Oct;73(4):624-30; discussion 630-1. doi: 10.1227/NEU.0000000000000064. 2. W ang X, Yang JN, Li X, Tailor R, Vassilliev O, Brown P, Rhines L, Chang E. Effect of spine hardware on small spinal stereotactic radiosurgery dosimetry. Phys Med Biol. 2013 Oct; 58(19):6733-47. Doi:10.1088/0031-9155/58/19/6733. Epub 2013 Sep 9 © 2014 Keck Medicine of USC 3. V erma J, Jonasch E, Allen PK, Weinberg JS, Tannir N, Chang EL, Mahajan A. The impact of tyrosine kinase inhibitors on the multimodality treatment of brain metastases from renal cell carcinoma. Am J Clin Oncol. 2013 Dec;36(6):620-4. doi: 10.1097/COC.0b013e31825d59db. For referrals, please call (323) 865-3050. For questions on topics covered here or for any other USC Radiation Oncology inquiries, please feel free to contact Nikos Carli, Senior Clinical Administrator, at [email protected] Department of Radiation Oncology Keck School of Medicine of USC USC Norris Comprehensive Cancer Center 1441 Eastlake Avenue Los Angeles, CA 90033-0804 For referrals, please call (323) 865-3050