* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project
Download Six Smart Facts About Antibiotic Use
Survey
Document related concepts
Transcript
Six Smart Facts About Antibiotic Use SIX SIMPLE AND SMART FACTS ABOUT ANTIBIOTIC USE 1. Antibiotics are life-saving drugs Using antibiotics wisely is the best way to preserve their strength for future bacterial illnesses. 2. Antibiotics only treat bacterial infections If your child has a viral infection like a cold, talk to a doctor or pharmacist about symptom relief. This may include over-the-counter medicine, a humidifier, or warm liquids. 3. Some ear infections DO NOT require an antibiotic A doctor can determine what kind of ear infection your child has and if antibiotics will help. The doctor may follow expert guidelines to wait a couple of days before prescribing antibiotics since your child may get better without them. 4. Most sore throats DO NOT require an antibiotic Only 1 in 5 children seen by a doctor for a sore throat has strep throat, which should be treated with an antibiotic. Your child’s doctor can only confirm strep throat by running a test. 5. Green colored mucus is NOT a sign that an antibiotic is needed As the body’s immune system fights off an infection, mucus can change color. This is normal and does not mean your child needs an antibiotic. 6. There are potential risks when taking any prescription drug Antibiotic use can cause complications, ranging from an upset stomach to a serious allergic reaction. Your child’s doctor will weigh the risks and benefits before prescribing an antibiotic. Get Smart symptom relief tips & tools for your child at: www.cdc.gov/getsmart or call 1-800-CDC-INFO (232-4636) National Center for Immunization and Respiratory Diseases Division of Bacterial Diseases CS232630-A Viruses cause common illnesses that antibiotics CANNOT treat like: •• Colds •• Influenza (the flu) •• Runny noses •• Most coughs •• Most bronchitis •• Most sore throats •• Most sinus infections •• Some ear infections Viral illnesses, like colds, usually go away without treatment in a week or two. Even many bacterial ear infections go away by themselves. When an antibiotic is not prescribed, ask your child’s doctor or pharmacist what can be used to relieve symptoms. Taking antibiotics for viral illnesses: •• Will NOT cure your child’s illness •• Will NOT help your child feel better •• Will NOT keep others from catching your child’s illness Bacteria cause illnesses like strep throat that are often treated successfully with antibiotics. Remember–there are potential risks when taking any prescription drug. Antibiotics should only be used when your child’s doctor determines they are needed. Most cough and cold illnesses are caused by viruses. Antibiotic use can only cure bacterial illnesses–not viral illnesses. Antibiotic use can: •• Kill good bacteria in your child’s body, which may lead to complications, such as diarrhea or yeast infection. •• Cause a serious allergic reaction that may require hospitalization. •• Result in an antibiotic-resistant infection. Resistant bacteria are stronger and harder to kill. They can stay in your child’s body and can cause severe illnesses that cannot be cured with antibiotics. A cure for a resistant infection may require stronger treatment– and possibly a hospital stay. Talk with your child’s doctor about the best way to care for your child during this illness. Viruses cause common illnesses that antibiotics CANNOT treat like: •• Colds •• Influenza (the flu) •• Runny noses •• Most coughs •• Most bronchitis •• Most sore throats •• Most sinus infections •• Some ear infections Viral illnesses, like colds, usually go away without treatment in a week or two. Even many bacterial ear infections go away by themselves. When an antibiotic is not prescribed, ask your child’s doctor or pharmacist what can be used to relieve symptoms. Taking antibiotics for viral illnesses: •• Will NOT cure your child’s illness •• Will NOT help your child feel better •• Will NOT keep others from catching your child’s illness Bacteria cause illnesses like strep throat that are often treated successfully with antibiotics. Remember–there are potential risks when taking any prescription drug. Antibiotics should only be used when your child’s doctor determines they are needed. Antibiotics Aren’t Always the Answer Antibiotic use can: •• Kill good bacteria in your child’s body, which may lead to complications, such as diarrhea or yeast infection. •• Cause a serious allergic reaction that may require hospitalization. •• Result in an antibiotic-resistant infection. Resistant bacteria are stronger and harder to kill. They can stay in your child’s body and can cause severe illnesses that cannot be cured with antibiotics. A cure for a resistant infection may require stronger treatment–and possibly a hospital stay. Talk with your child’s doctor about the best way to care for your child during this illness. Get Smart symptom relief tips & tools for your child at: www.cdc.gov/getsmart or call 1-800-CDC-INFO (232-4636) CS232630-B Most cough and cold illnesses are caused by viruses. ANTIBIOTIC use can only cure bacterial illnesses–not viral illnesses. 5. Green SIX SIMPLE AND SMART FACTS ABOUT ANTIBIOTIC USE 3. Some ear infections DO NOT require an antibiotic 1. Antibiotics are life-saving drugs Using antibiotics wisely is the best way to preserve their strength for future bacterial illnesses. 2. Antibiotics A doctor can determine what kind of ear infection your child has and if antibiotics will help. The doctor may follow expert guidelines to wait for a couple of days before prescribing antibiotics since your child may get better without them. 4. Most sore only treat bacterial infections throats DO NOT require an antibiotic If your child has a viral infection like a cold, talk to a doctor or pharmacist about symptom relief. This may include overthe-counter medicine, a humidifier, or warm liquids. Only 1 in 5 children seen by a doctor for a sore throat has strep throat, which should be treated with an antibiotic. Your child’s doctor can only confirm strep throat by running a test. colored mucus is NOT a sign that an antibiotic is needed As the body’s immune system fights off an infection, mucus can change color. This is normal and does not mean your child needs an antibiotic. 6. There are potential risks when taking any prescription drug Antibiotic use can cause complications, ranging from an upset stomach to a serious allergic reaction. Your child’s doctor will weigh the risks and benefits before prescribing an antibiotic. Antibiotics Aren’t Always the Answer SIX SIMPLE AND SMART FACTS ABOUT ANTIBIOTIC USE 1. Antibiotics are life-saving drugs Using antibiotics wisely is the best way to preserve their strength for future bacterial illnesses. 2. Antibiotics only treat bacterial infections If your child has a viral infection like a cold, talk to a doctor or pharmacist about symptom relief. This may include over-the-counter medicine, a humidifier, or warm liquids. 3. Some ear infections DO NOT require an antibiotic A doctor can determine what kind of ear infection your child has and if antibiotics will help. The doctor may follow expert guidelines to wait a couple of days before prescribing antibiotics since your child may get better without them. 4. Most sore throats DO NOT require an antibiotic Only 1 in 5 children seen by a doctor for a sore throat has strep throat, which should be treated with an antibiotic. Your child’s doctor can only confirm strep throat by running a test. 5. Green colored mucus is NOT a sign that an antibiotic is needed As the body’s immune system fights off an infection, mucus can change color. This is normal and does not mean your child needs an antibiotic. 6. There are potential risks when taking any prescription drug Antibiotic use can cause complications, ranging from an upset stomach to a serious allergic reaction. Your child’s doctor will weigh the risks and benefits before prescribing an antibiotic. Get Smart symptom relief tips & tools for your child at: www.cdc.gov/getsmart or call 1-800-CDC-INFO (232-4636) National Center for Immunization and Respiratory Diseases Division of Bacterial Diseases CS232630-C Adult Treatment Recommendations Antibiotic prescribing guidelines establish standards of care and focus quality improvement efforts. The table below summarizes the most recent recommendations for appropriate antibiotic prescribing for adults seeking care in an outpatient setting. Condition Acute rhinosinusitis1, 2 Epidemiology About 1 out of 8 adults (12%) in 2012 reported receiving a diagnosis of rhinosinusitis in the previous 12 months, resulting in more than 30 million diagnoses. Ninety–98% of rhinosinusitis cases are viral, and antibiotics are not guaranteed to help even if the causative agent is bacterial. Diagnosis Acute uncomplicated bronchitis3-5 Cough is the most common symptom for which adult patients visit their primary care provider, and acute bronchitis is the most common diagnosis in these patients. Common cold or non-specific upper respiratory tract infection (URI)6,7 The common cold is the third most frequent diagnosis in office visits, and most adults experience two to four colds annually. At least 200 viruses can cause the common cold. Management Diagnose acute bacterial rhinosinusitis based on symptoms that are: o Severe (>3-4 days), such as a fever ≥39°C (102°F) and purulent nasal discharge or facial pain; o Persistent (>10 days) without improvement, such as nasal discharge or daytime cough; or o Worsening (3-4 days) such as worsening or new onset fever, daytime cough, or nasal discharge after initial improvement of a viral upper respiratory infections (URI) lasting 5-6 days. Sinus radiographs are not routinely recommended. If a bacterial infection is established: Watchful waiting is encouraged for uncomplicated cases for which reliable follow-up is available. Amoxicillin or amoxicillin/clavulanate is the recommended first-line therapy. Macrolides such as azithromycin are not recommended due to high levels of Streptococcus pneumoniae antibiotic resistance (~40%). For penicillin-allergic patients, doxycycline or a respiratory fluoroquinolone (levofloxacin or moxifloxacin) are recommended as alternative agents. Evaluation should focus on ruling out pneumonia, which is rare among otherwise healthy adults in the absence of abnormal vital signs (heart rate ≥ 100 beats/min, respiratory rate ≥ 24 breaths/min, or oral temperature ≥ 38 °C) and abnormal lung examination findings (focal consolidation, egophony, fremitus). Colored sputum does not indicate bacterial infection. For most cases, chest radiography is not indicated. Routine treatment of uncomplicated acute bronchitis with antibiotics is not recommended, regardless of cough duration. Prominent cold symptoms include fever, cough, rhinorrhea, nasal congestion, postnasal drip, sore throat, headache, and myalgias. 1 Options for symptomatic therapy include: Cough suppressants (codeine, dextromethorphan); First-generation antihistamines (diphenhydramine); Decongestants (phenylephrine); and Beta agonists (albuterol). Decongestants (pseudoephedrine and phenylephrine) combined with a first-generation antihistamine may provide short-term symptom relief of nasal symptoms and cough. Non-steroidal anti-inflammatory drugs can be given to relieve symptoms. Evidence is lacking to support antihistamines (as monotherapy), opioids, intranasal corticosteroids, and nasal saline irrigation as effective treatments for cold symptom relief. Providers and patients must weigh the benefits and harms of symptomatic therapy. Pharyngitis8,9 Acute uncomplicated cystitis 10, 11 Group A beta-hemolytic streptococcal (GAS) infection is the only common indication for antibiotic therapy for sore throat cases. Only 5–10% of adult sore throat cases are caused by GAS. Cystitis is among the most common infections in women and is usually caused by E. coli. Clinical features alone do not distinguish between GAS and viral pharyngitis; a rapid antigen detection test (RADT) is necessary to establish a GAS pharyngitis diagnosis Those who meet two or more Centor criteria (e.g., fever, tonsillar exudates, tender cervical lymphadenopathy, absence of cough) should receive a RADT. Throat cultures are not routinely recommended for adults. Classic symptoms include dysuria, frequent voiding of small volumes, and urinary urgency. Hematuria and suprapubic discomfort are less common. Nitrites and leukocyte esterase are the most accurate indicators of acute uncomplicated cystitis 2 Antibiotic treatment is NOT recommended for patients with negative RADT results. Amoxicillin and penicillin V remain first-line therapy due to their reliable antibiotic activity against GAS. For penicillin-allergic patients, cephalexin, cefadroxil, clindamycin, or macrolides are recommended. GAS antibiotic resistance to azithromycin and clindamycin are increasingly common. Recommended treatment course for all oral beta lactams is 10 days. For acute uncomplicated cystitis in healthy adult non-pregnant, premenopausal women: Nitrofurantoin, trimethoprim/sulfamethoxazole (TMP-SMX, where local resistance is <20%), and fosfomycin are appropriate first-line agents. Fluoroquinolones (e.g. ciprofloxacin) should be reserved for situations in which other agents are not appropriate. References 1) Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, et al. Clinical practice guideline (updated): adult sinusitis. Otolaryngol Head Neck Surg. 2015;152(2 Suppl):S1-39. 2) Chow AW, Benninger MS, Itzhak B, et al. IDSA clinical practice guideline for acute bacterial rhinosinusitis in children and adults. Clin Infect Dis. 2012;54(8):e72-e112. 3) Albert RH. Diagnosis and treatment of acute bronchitis. Am Fam Physician. 2010;82(11):1345-50. 4) Irwin RS, Baumann MH, Bolser DC, et al. Diagnosis and management of cough: ACCP evidence-based clinical practice guidelines. Chest. 2006;129(1 Suppl). 5) Gonzales R, Bartlett JG, Besser RE, et al. Principles of appropriate antibiotic use for treatment of uncomplicated acute bronchitis: Background. Ann Intern Med. 2001;134(6):521-9. 6) Fashner J, Ericson K, Werner S. Treatment of the common cold in children and adults. Am Fam Physician. 2012;86(2):153-9. 7) Pratter MR. Cough and the common cold: ACCP evidence-based clinical practice guidelines. Chest. 2006;129(1 Suppl): 72S-74S. 8) Shulman ST, Bisno AL, Clegg HW, et al. Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America. Clin Infect Dis. 2012;55(10):e86-102. 9) Cooper RJ, Hoffman JR, Bartlett JG, et al. Principles of appropriate antibiotic use for acute pharyngitis in adults: Background. Ann Intern Med. 2001;134(6):509-17. 10) Gupta K, Hooton TM, Naber KG, et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis. 2011;52(5):e103-20. 11) Colgan R, Williams M. Diagnosis and treatment of acute uncomplicated cystitis. Am Fam Physician. 2011;84(7):771-6. 3 GET SMART About Antibiotics Week RESISTANCE ANYWHERE IS RESISTANCE EVERYWHERE WWW.CDC.GOV/GETSMART Antibiotic Resistance Can Travel the Globe • Often called superbugs, some bacteria are already resistant to most or all known antibiotics. One example is CRE, a family of germs that is resistant to our most powerful drugs of last-resort. • Sometimes called “nightmare bacteria” because they are so difficult to treat, CRE was originally found in only one U.S. state but has spread. • Klebsiella pneumoniae carbapenemase (KPC) infections, a type of CRE, were once seen in limited locations in the U.S. but are now found throughout the country. • Another type of CRE, caused by New Delhi metallo-beta-lactamase (NDM-1), was initially identified in India, but is now present in several other countries including the U.S., Canada, Netherlands, United Kingdom, Australia, and beyond. Why We Must Act Now Graphical Distribution of Klebsiella pneumonia carbapenemase (KPC) Infection Did You Know? 1. Antibiotic resistance is one of the world’s most pressing public health threats. States with KPC producing organisims 2. Antibiotics are the most important tool we have to combat lifethreatening bacterial diseases, but using antibiotics can have side effects. 3. Antibiotic overuse increases the development of drug-resistant germs. 4. Patients, healthcare providers, hospital administrators, and policy makers must work together to use effective strategies for improving antibiotic use—ultimately improving medical care and saving lives. 2001 2015 • The way we use antibiotics today or in one patient directly impacts how effective they will be tomorrow or in another patient; they are a shared resource. • Antibiotic resistance is not just a problem for the person with the infection. Some resistant bacteria have the potential to spread to others—promoting antibiotic-resistant infections. • Since it will be many years before new antibiotics are available to treat some resistant infections, we need to improve the use of antibiotics that are currently available. Outpatient antibiotic use: U.S. compared to Europe (2004) Defined Daily Dose/1,000 inhabitants per day GREECE FRANCE United States: 24.9 ITALY UNITED STATES LUXEMBERG PORTUGAL SLOVAKIA ICELAND IRELAND ISRAEL EUROPE SPAIN HUNGARY Europe: 19.0 FINLAND SLOVENIA NORWAY UNITED KINGDOM LATVIA GERMANY NETHERLANDS 0 5 10 15 20 25 Source: Goosens et al. CID 2007;44:1091-5; erratum CID 2007; 44:1259 CS260605E 30 35 Global Health Professionals Can: • Spread the message that antibiotic resistance is a global problem. • Implement hospital infection-control measures to reduce the spread of multidrug-resistant strains and reinforce national policies on prudent use of antibiotics, reducing the generation of antibiotic-resistant bacteria. • Adhere to World Health Organization’s strong recommendations that governments focus control and prevention efforts in four main areas: 1. Surveillance for antimicrobial resistance; 2. Rational antibiotic use, including education of healthcare workers and the public in the appropriate use of antibiotics; 3. Introduction or enforcement of legislation related to stopping the sale of antibiotics without prescription; and 4. Strict adherence to infection prevention and control measures, including safe handwashing measures, particularly in healthcare facilities. • Develop relevant policies and coordinate international efforts with the support of WHO to combat antimicrobial resistance. For more information, visit CDC’s Get Smart Program Website Get Smart About Antibiotics Week http://www.cdc.gov/getsmart/week/index.html Get Smart Resources for Policy Makers http://www.cdc.gov/getsmart/week/educational-resources/policy-makers.html Centers for Disease Control and Prevention For more information, please contact Centers for Disease Control and Prevention. 1600 Clifton Road N.E., Atlanta, GA 30333 Telephone: 1-800-CDC-INFO (232-4636)/TTY: 1-888-232-63548 Email: [email protected] Web: http://www.cdc.gov/getsmart/ GET SMART ANTIBIOTIC RESISTANCE: THE GLOBAL THREAT About Antibiotics Week WWW.CDC.GOV/GETSMART Super-Resistant Bacteria: Problem Today, Crisis Tomorrow • In India, 58,000+ babies died in one year from super-resistant bacterial infections, which are usually passed on from their mothers1 • In the European Union, antibiotic resistance causes 25,000 deaths per year and 2.5m extra hospital days2 • In Thailand, antibiotic resistance causes 38,000+ deaths per year and 3.2m hospital days2 Antibiotic resistance—when bacteria no longer respond to the drugs designed to kill them—is happening right now across the world. • In the United States, antibiotic resistance causes 23,000+ deaths per year and more than 2m illnesses2 Global Action to Slow Resistance • Improve Laboratory Capacity: Countries need medical labs to identify bacteria and choose the right drugs to treat them. When people get antibiotics without this testing, they: −− Often get treatment that doesn’t help −− Develop and spread resistant bacteria −− Increase their risk for future resistant infections • Develop National Tracking Programs: Countries need the infrastructure to collect resistance data and report results globally. This information is necessary to: The full impact is unknown. There is no system in place to track antibiotic resistance globally. −− Target and measure prevention efforts −− Drive policies that help stop spread • Implement Antibiotic Stewardship Programs: To ensure antibiotics are here when we need them, they must be prescribed and taken correctly now. • Expand Infection Control Programs: Improving infection control practices in healthcare settings is critical to prevent spread of antibiotic-resistant germs. CDC’s Impact on a Global Threat CDC’s proposed Antibiotic Resistance Solutions Initiative will: • Allow standardized tracking of antibiotic resistance internationally Without urgent action, modern medicine will be obsolete and minor injuries will once again be deadly. • Prevent antibiotic resistance • Improve antibiotic prescribing and use • Boost communication of antibiotic resistance threats http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(13)70318-9/fulltext 1 Anticrobial Resistance Global Report on Surveillance, 2014. WHO Report. http://www.who.int/drugresistance/documents/AMR_report_Web_slide_set.pdf?ua=1 2 CS260606C GLOBAL THREAT GET SMART About Antibiotics Week WWW.CDC.GOV/GETSMART FOR PARENTS ANTIBIOTICS AREN’T ALWAYS THE ANSWER Many common infections are becoming resistant to antibiotics. As a parent, ask questions to make sure your sick child is getting the best care possible, which might not include an antibiotic. The Facts: • Antibiotics can have reactions and side effects. Harmful effects from antibiotics, such as side effects and allergic reactions, cause 1 out of 5 emergency department visits for adverse drug events and lead to 50,000 emergency department visits in children each year.1 • Antibiotics can be overused and misused. It is estimated that more than half of antibiotics are unnecessarily prescribed to children in doctor office settings for cough and cold illness, most of which are caused by viruses. • Antibiotics can only cure infections caused by bacteria, not viruses. • Antibiotic resistance is growing. An estimated 2 million illnesses and 23,000 deaths occur each year in the United States due to antibiotic-resistant infections.2 Overuse and misuse of antibiotics are main drivers of resistance. ? CS260605B ? ? ? ? Questions to Ask Your Provider If your child is sick, here are 3 important questions to ask your healthcare professional: 1. What is the best treatment for my child’s illness? Antibiotics aren’t needed for common illnesses like colds, most sore throats, the flu, and even some ear infections. These illnesses are often caused by viruses, which do not respond to antibiotics. Sometimes the best treatment is symptom relief. 2. Is this the right antibiotic for the type of infection my child has? If an antibiotic will help your child, it’s important to use an antibiotic that is designed to fight the bacteria causing your child’s specific illness. If your healthcare professional says your child needs an antibiotic, ask if it’s the one most “targeted” to treat the infection while causing the least side effects. 3. What can I do to help my child feel better? Pain relievers, fever reducers, saline nasal spray or drops, warm compresses, liquids, and rest may be the best things to help your child feel better. Ask your healthcare provider or pharmacist what symptom relief is best for your child. Centers for Disease Control and Prevention For more information, please contact Centers for Disease Control and Prevention. 1600 Clifton Road N.E., Atlanta, GA 30333 Telephone: 1-800-CDC-INFO (232-4636)/TTY: 1-888-232-63548 Email: [email protected] Web: www.cdc.gov/getsmart Citations: 1 Bourgeois FT, et al. Pediatric adverse drug events in the outpatient setting: An 11-year national analysis. Pediatrics. 2009;124:e744-50. 2 CDC. Antibiotic Resistance Threats in the United States, 2013. 16 September 2013. GET SMART About Antibiotics Week WWW.CDC.GOV/GETSMART FOR PARENTS ANTIBIOTICS AREN’T ALWAYS THE ANSWER Many common infections are becoming resistant to antibiotics. As a parent, ask questions to make sure your sick child is getting the best care possible, which might not include an antibiotic. The Facts: • Antibiotics can have reactions and side effects. Harmful effects from antibiotics, such as side effects and allergic reactions, cause 1 out of 5 emergency department visits for adverse drug events and lead to 50,000 emergency department visits in children each year.1 • Antibiotics can be overused and misused. It is estimated that more than half of antibiotics are unnecessarily prescribed to children in doctor office settings for cough and cold illness, most of which are caused by viruses. • Antibiotics can only cure infections caused by bacteria, not viruses. • Antibiotic resistance is growing. An estimated 2 million illnesses and 23,000 deaths occur each year in the United States due to antibiotic-resistant infections.2 Overuse and misuse of antibiotics are main drivers of resistance. ? CS260605B ? ? ? ? Questions to Ask Your Provider If your child is sick, here are 3 important questions to ask your healthcare professional: 1. What is the best treatment for my child’s illness? Antibiotics aren’t needed for common illnesses like colds, most sore throats, the flu, and even some ear infections. These illnesses are often caused by viruses, which do not respond to antibiotics. Sometimes the best treatment is symptom relief. 2. Is this the right antibiotic for the type of infection my child has? If an antibiotic will help your child, it’s important to use an antibiotic that is designed to fight the bacteria causing your child’s specific illness. If your healthcare professional says your child needs an antibiotic, ask if it’s the one most “targeted” to treat the infection while causing the least side effects. 3. What can I do to help my child feel better? Pain relievers, fever reducers, saline nasal spray or drops, warm compresses, liquids, and rest may be the best things to help your child feel better. Ask your healthcare provider or pharmacist what symptom relief is best for your child. Centers for Disease Control and Prevention For more information, please contact Centers for Disease Control and Prevention. 1600 Clifton Road N.E., Atlanta, GA 30333 Telephone: 1-800-CDC-INFO (232-4636)/TTY: 1-888-232-63548 Email: [email protected] Web: www.cdc.gov/getsmart Citations: 1 Bourgeois FT, et al. Pediatric adverse drug events in the outpatient setting: An 11-year national analysis. Pediatrics. 2009;124:e744-50. 2 CDC. Antibiotic Resistance Threats in the United States, 2013. 16 September 2013. W hen you feel sick, you want to feel better fast. But antibiotics aren’t the answer for every illness. This brochure can help you know when antibiotics work – and when they won’t. For more information, talk to your healthcare provider or visit www.cdc.gov/getsmart. The Risk: Bacteria Become Resistant What’s the harm in taking antibiotics anytime? Using antibiotics when they are not needed causes some bacteria to become resistant to the antibiotic. These resistant bacteria are stronger and harder to kill. They can stay in your body and can cause severe illnesses that cannot be cured with antibiotics. A cure for resistant bacteria may require stronger treatment – and possibly a stay in the hospital. To avoid the threat of antibiotic-resistant infections, the Centers for Disease Control and Prevention (CDC) recommends that you avoid taking unnecessary antibiotics. Antibiotics Aren’t Always the Answer Most illnesses are caused by two kinds of germs: bacteria or viruses. Antibiotics can cure bacterial infections – not viral infections. Bacteria cause strep throat, some pneumonia and sinus infections. Antibiotics can work. Viruses cause the common cold, most coughs and the flu. Antibiotics don’t work. Using antibiotics for a virus: • Will NOT cure the infection • Will NOT help you feel better • Will NOT keep others from catching your illness Protect Yourself With the Best Care Y ou should not use antibiotics to treat the common cold or the flu. If antibiotics are prescribed for you to treat a bacterial infection – such as strep throat – be sure to take all of the medicine. Only using part of the prescription means that only part of the infection has been treated. Not finishing the medicine can cause resistant bacteria to develop. Talk to Your Healthcare Provider to Learn More ? Commonly Asked Questions: How Do I Know if I Have a Viral or Bacterial Infection? Ask your healthcare provider and follow his or her advice on what to do about your illness. Remember, colds are caused by viruses and should not be treated with antibiotics. Won’t an Antibiotic Help Me Feel Better Quicker so That I Can Get Back to Work When I Get a Cold or the Flu? No, antibiotics do nothing to help a viral illness. They will not help you feel better sooner. Ask your healthcare provider what other treatments are available to treat your symptoms. If Mucus from the Nose Changes from Clear to Yellow or Green — Does This Mean I Need an Antibiotic? No. Yellow or green mucus does not mean that you have a bacterial infection. It is normal for mucus to get thick and change color during a viral cold. GET SMART… •Antibiotics are strong medicines, but they don’t cure everything. •When not used correctly, antibiotics can actually be harmful to your health. •Antibiotics can cure most bacterial infections. Antibiotics cannot cure viral illnesses. •Antibiotics kill bacteria – not viruses. •When you are sick, antibiotics are not always the answer. USE ANTIBIOTICS WISELY Talk with your healthcare provider about the right medicines for your health. Cold or Flu. Antibiotics Don’t Work for You. For more information, see the Centers for Disease Control and Prevention website at: www.cdc.gov/getsmart or call 1-800-CDC-INFO A GUIDE FOR PARENTS QUESTIONS AND ANSWERS Fluid in the Middle Ear (Otitis Media with Effusion) A healthcare provider said your child has fluid in the middle ear, also called otitis (oh-TIE-Tus) media with effusion (uh-FEW-zhun) (OME). Fluid usually does not bother children, and it almost always goes away on its own. This does not have to be treated with antibiotics, unless it lasts for a few months. Here are some facts about OME and ear infections. What are the main kinds of ear infections? • S wimmer’s ear (otitis externa) is an infection of the ear canal that can be painful and is treated with eardrops. • A middle ear infection, which a healthcare provider might call “acute otitis media” (AOM), may cause ear pain, fever, or an inflamed eardrum, and is often treated with oral antibiotics. What causes OME? Fluid may build up in the middle ear for two reasons. When a child has a cold, the middle ear makes fluid just as the nose does – it just doesn’t run out as easily from the middle ear. After a middle ear infection, fluid may take a month or longer to go away. Are antibiotics ever needed for OME? Sometimes antibiotics may be needed if the fluid is still present after a few months and is causing decreased hearing in both ears. For this reason, your child will need an ear check in a few months. If there is still fluid in the middle ear, your child may need a hearing test. What should I do? • T he best treatment is to wait and watch your child. Since fluid in the middle ear rarely bothers children, it is best to let it go away on its own. Right now, your child does not need antibiotics. • Y ou may need to schedule a visit to see the healthcare provider again in a few months to be sure the fluid is gone. Why not try antibiotics now? Taking antibiotics when they are not needed can be harmful. Each time people take antibiotics, they are more likely to carry resistant germs in their noses and throats. These resistant germs cannot be killed by common antibiotics. Your child may need more costly antibiotics, antibiotics given by a needle, or may even need to be in the hospital to get antibiotics. Since OME will almost always get better on its own, it is better to wait and take antibiotics only when they are needed. 1-800-CDC-INFO www.cdc.gov/getsmart Is it Really a Penicillin Allergy? Evaluation and Diagnosis of Penicillin Allergy for Healthcare Professionals Did You Know? 5 Facts About Penicillin Allergy (Type 1, Immunoglobulin E (IgE)-mediated) 1. Approximately 10% of all U.S. patients report having an allergic reaction to a penicillin class antibiotic in their past. 2. However, many patients who report penicillin allergies do not have true IgE-mediated reactions. When evaluated, fewer than 1% of the population are truly allergic to penicillins.1 3. Approximately 80% of patients with IgE-mediated penicillin allergy lose their sensitivity after 10 years.1 4. Broad-spectrum antibiotics are often used as an alternative to penicillins. The use of broad-spectrum antibiotics in patients labeled “penicillin-allergic” is associated with higher healthcare costs, increased risk for antibiotic resistance, and suboptimal antibiotic therapy.1 5. Correctly identifying those who are not actually penicillin-allergic can decrease unnecessary use of broad-spectrum antibiotics.1 10% of the population reports a penicillin allergy but <1% of the whole population is truly allergic. Before prescribing broad-spectrum antibiotics to a patient thought to be penicillin-allergic, evaluate the patient for true penicillin allergy (IgE-mediated) by conducting a history and physical, and, when appropriate, a skin test and challenge dose. History and Physical Examination The history and physical examination are important components when evaluating a patient’s drug reactions.1 •• Questions to ask during the examination: –– What medication were you taking when the reaction occurred? –– What kind of reaction occurred? –– How long ago did the reaction occur? –– How was the reaction managed? –– What was the outcome?2 •• Characteristics of an IgE-mediated (Type 1) reaction: –– Reactions that occur immediately or usually within one hour1 –– Hives: Multiple pink/red raised areas of skin that are intensely itchy3 –– Angioedema: Localized edema without hives affecting the abdomen, face, extremities, genitalia, oropharynx, or larynx4 –– Wheezing and shortness of breath –– Anaphylaxis1 requires signs or symptoms in at least two of the following systems: Skin: Hives, flushing, itching, and/or angioedema (continued on next page) National Center for Emerging and Zoonotic Infectious Diseases Division of Healthcare Quality Promotion CS262078 •• Broad-spectrum antibiotics are often used as an alternative to narrow-spectrum penicillins. •• Using broad-spectrum antibiotics can increase healthcare costs and antibiotic resistance, and may mean your patient receives less than the best care. •• Correctly identifying if your patient is actually penicillin-allergic can decrease these risks by reducing unnecessary use of broadspectrum antibiotics. (continued from previous page) Respiratory: Cough, nasal congestion, shortness of breath, chest tightness, wheeze, sensation of throat closure or choking, and/or change in voice-quality (laryngeal edema) Cardiovascular: Hypotension, faintness, tachycardia or less commonly bradycardia, tunnel vision, chest pain, sense of impending doom, and/or loss of consciousness Gastrointestinal: Nausea, vomiting, abdominal cramping, and diarrhea5 Penicillin Skin Tests and Challenge Doses Based on the patient history and physical exam, additional tests may be needed to confirm a penicillin allergy. Penicillin skin testing is a reliable and useful method for evaluating IgE-mediated penicillin allergy.5 A positive result means the patient is likely to have a penicillin allergy. If negative, the skin test is usually followed by an oral penicillin class challenge (e.g., with amoxicillin) to safely rule out an IgE-mediated penicillin allergy.1,7 •• Skin tests currently include penicilloylpolylysine, the major antigenic determinant that indicates hypersensitivity to penicillin. •• However, it is important to note that the patient can also be allergic to other reactive breakdown products, called minor determinants, which include penicillin G (benzylpenicillin), penicilloate, and penilloate—many of which are not commercially available. Of these, only penicillin G is available from pharmacies. •• To rule out penicillin allergy, an oral challenge dose can be done after skin testing. The negative predictive value of skin testing with the major and minor determinants is more than 95%, but approaches 100% when followed by a challenge dose.2 Special Considerations Patients with severe hypersensitivity syndromes Patients with other severe hypersensitivity syndromes—like Stevens-Johnson syndrome, toxic epidermal necrolysis, serum sickness, acute interstitial nephritis, hemolytic anemia, and drug rash with eosinophilia and systemic symptoms (DRESS)—should not use the offending drug in the future. The skin test and challenge described here are not appropriate for patients with these severe hypersensitivity syndromes.1,2,6 Cephalosporin use in penicillin-allergic patients Many cephalosporins, especially in the later generations, can be safely tolerated despite a penicillin allergy.6,8 Patients with anaphylaxis or other severe reactions to penicillin may require further evaluation prior to the use of cephalosporins. Pediatric patients Children who are receiving amoxicillin or ampicillin and have Epstein-Barr virus infection can develop a non-allergic, non-pruritic rash that can appear similar to an IgE-mediated reaction.1,9 For more information about appropriate antibiotic use, visit www.cdc.gov/getsmart. References 1. Joint Task Force on Practice Parameters representing the American Academy of Allergy, Asthma and Immunology; American College of Allergy, Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology. Drug allergy: an updated practice parameter. Ann Allergy Asthma Immunol. 2010 Oct;105(4):259-273. 2. Gonzalez-Estrada A, Radojicic C. Penicillin allergy: a practical guide for clinicians. Cleve Clin J Med. 2015 May;82(5):295-300. 3. Herrier RN, Apgar DA, Boyce RW, Foster SL. Patient assessment in pharmacy. New York: McGraw-Hill; 2015 [cited 2015 Aug 14]. Available from: http://accesspharmacy.mhmedical.com/ content.aspx?bookid=1074&Sectionid=62364288. 4. Bernstein JA. Update on angioedema: evaluation, diagnosis, and treatment. Allergy Asthma Proc 2011; 32(6):408-412. 5. Sampson HA, Muñoz-Furlong A, Campbell RL, Adkinson NF Jr, Bock SA, Branum A et al. Second symposium on the definition and management of anaphylaxis: summary report–second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. Ann Emerg Med. 2006; 47:373-380. 6. Blumenthal KG, Shenoy ES, Hurwitz S, Varughese CA, Hooper DC, Banerji A. Effect of a drug allergy educational program and antibiotic prescribing guideline on inpatient clinical providers’ antibiotic prescribing knowledge. J Allergy Clin Immunol. 2014;2(4):407-412. 7. Macy E, Ngor E. Recommendations for the management of beta-lactam intolerance. Clinical Rev Allerg Immunol. 2014; 47:46-55. 8. Pichichero, ME. A review of evidence supporting the American Academy of Pediatrics recommendation for prescribing cephalosporin antibiotics for penicillin-allergic patients. Pediatrics. 2005 Apr; 115(4):1048-1057. 9. Centers for Disease Control and Prevention [Internet]. About Epstein-Barr Virus (EBV) [cited 2015 Aug 17]. Available from: http://www.cdc.gov/epstein-barr/about-ebv.html. CDC thanks Mina Hong, PharmD Student Class of 2016 at Northeastern University, and Kimberly G. Blumenthal, MD, Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, for their assistance preparing this fact sheet. Page 2 of 2 Antibiotics are strong medicines. Keep them that way. Prevent antibiotic resistance. Antibiotics don’t fight Taking antibiotics for viral infections such viruses—they fight bacteria. Using antibiotics for viruses can put you at risk of • Cure the infection getting a bacterial infection that is resistant to antibiotic treatment. Talk to your • Keep other people from catching it healthcare provider about antibiotics, visit www.cdc.gov/getsmart, • Help you feel better or call 1-800-CDC-INFO to learn more. CS121386 as a cold, a cough, or the flu will not: GET SMART About Antibiotics Week WWW.CDC.GOV/GETSMART FOR PROVIDERS PRESERVE THE POWER OF ANTIBIOTICS Antibiotic-resistant bacteria cause more than 2 million illnesses and at least 23,000 deaths each year in the United States. Antibiotic resistance occurs when germs no longer respond to the drugs designed to kill them. Inappropriate prescribing of antibiotics contributes to antibiotic resistance and is a threat to patient safety. Healthcare Providers Can: •Prescribe correctly −−Avoid treating viral syndromes with antibiotics, even when patients ask for them. −−Pay attention to dose and duration: The right antibiotic needs to be prescribed at the right dose for the right duration. −−Be aware of antibiotic-resistance patterns in your area so that you can always choose the right antibiotic. −−Hospital and nursing home providers should reassess within 48 hours of starting the antibiotic, when the patient’s culture results come back. Adjust the prescription, if necessary. Stop the prescription, if indicated. •Collaborate with each other and with patients −−Talk to your patients about appropriate use of antibiotics. −−Include microbiology cultures, when possible, when ordering antibiotics. −−Work with pharmacists to ensure appropriate antibiotic use and prevent resistance and adverse events. −−Use patient and provider resources offered by the Centers for Disease Control and Prevention (CDC) and professional organizations such as Society for Healthcare Epidemiology. ♦♦ Provider Resources: http://www.cdc.gov/getsmart/ ♦♦ Patient Resources: http://www.cdc.gov/getsmart/community/for-patients/index.html ♦♦ General Information: http://www.cdc.gov/drugresistance/protecting_yourself_family.html •Stop the spread −−Follow hand hygiene and other infection control measures with every patient. •Embrace antibiotic stewardship −−Improve antibiotic use in all facilities—regardless of size—through stewardship interventions and programs, which will improve individual patient outcomes, reduce the overall burden of antibiotic resistance, and save healthcare dollars. −−Recognize and participate in CDC’s Get Smart About Antibiotics Week initiatives. CS260605A2 Inpatient Settings •Overuse of antibiotics creates an unnecessary risk for adverse drug events, such as Clostridium difficile infection, a sometimes deadly diarrhea. •Antibiotic resistance adversely impacts the health of millions of hospitalized patients every year. •Some infections in hospitals are now resistant to all available antibiotics. •About 40% of the patients receiving antibiotics receive unnecessary or inappropriate therapy. Outpatient Settings •Each year, millions of antibiotics are prescribed unnecessarily for viral infections. •Antibiotics can cause adverse drug events and promote antibiotic resistance. −−There are more Clostridium difficile infections in places with more antibiotic use. −−Antibiotic use in primary care is associated with antibiotic resistance at the individual patient level. •Antibiotics cause 1 in 5 emergency department visits for adverse drug events and are the most common cause of emergency department visits for adverse drug events in children. For more information, visit CDC’s Get Smart program website: Get Smart Resources for Healthcare Providers http://www.cdc.gov/getsmart/week/educational-resources/hcp.html Centers for Disease Control and Prevention For more information, please contact Centers for Disease Control and Prevention. 1600 Clifton Road N.E., Atlanta, GA 30333 Telephone: 1-800-CDC-INFO (232-4636)/TTY: 1-888-232-63548 Email: [email protected] Web: www.cdc.gov/getsmart A GUIDE FOR PARENTS QUESTIONS AND ANSWERS Runny Nose (with green or yellow mucus) Y our child has a runny nose. This is a normal part of what happens during the common cold and as it gets better. Here are some facts about colds and runny noses. What causes a runny nose during a cold? When germs that cause colds first infect the nose and sinuses, the nose makes clear mucus. This helps wash the germs from the nose and sinuses. After two or three days, the body’s immune cells fight back, changing the mucus to a white or yellow color. As the bacteria that live in the nose grow back, they may also be found in the mucus, which changes the mucus to a greenish color. This is normal and does not mean your child needs an antibiotic. Are antibiotics ever needed for a runny nose? Antibiotics are needed only if your healthcare provider tells you that your child has sinusitis. Your child’s healthcare provider may prescribe other medicine or give you tips to help with a cold’s other symptoms like fever and cough, but antibiotics are not needed to treat the runny nose. Why not try antibiotics now? What should I do? • T he best treatment is to wait and watch your child. Runny nose, cough, and symptoms like fever, headache, and muscle aches may be bothersome, but antibiotics will not make them go away any faster. • S ome people find that using a cool mist vaporizer or saltwater nose drops makes their child feel better. Taking antibiotics when they are not needed can be harmful. Each time people take antibiotics, they are more likely to carry resistant germs in their noses and throats. These resistant germs cannot be killed by common antibiotics. Your child may need more costly antibiotics, antibiotics given by a needle, or may even need to be in the hospital to get antibiotics. Since a runny nose almost always gets better on its own, it is better to wait and take antibiotics only when they are needed. 1-800-CDC-INFO www.cdc.gov/getsmart GET SMART SAVE MONEY WITH ANTIBIOTIC STEWARDSHIP About Antibiotics Week WWW.CDC.GOV/GETSMART Antibiotic stewardship programs and interventions help ensure that patients get the right antibiotics at the right time for the right duration. Numerous studies have shown that RETURN ON INVESTMENT implementing an antibiotic stewardship program can not only save lives, but can save significant healthcare dollars. Inpatient antibiotic stewardship programs have consistently demonstrated annual savings to hospitals and other healthcare facilities of $200,000 to $400,000. Antibiotic stewardship in your facility will: Increase good patient outcomes Decrease antibiotic resistance Did You Know? 1. Antibiotic resistance is one of the world’s most pressing public health threats. 2. Antibiotic overuse increases the development of drugresistant germs. 3. Antibiotics are the most important tool we have to combat life-threatening bacterial diseases, but antibiotics can have side effects. 4. Patients, healthcare providers, hospital administrators, and policy makers must work together to use effective strategies for improving antibiotic use—ultimately improving medical care and saving lives. CS267085 Decrease C. difficile infections Decrease costs • According to a University of Maryland study, implementation of one antibiotic stewardship program saved a total of $17 million in a span of seven years at one institution. After the program was discontinued, antibiotic costs increased by more than one million dollars in the first year (an increase of 32 percent) and continued to increase the following year. • In a study conducted at The Johns Hopkins Hospital, it was demonstrated that guidelines for management of community-acquired pneumonia could promote the use of shorter courses of therapy, saving money and promoting patient safety. • Targeting certain infections may decrease antibiotic use. For example, determining when and how to treat patients for urinary tract infections, the second most common bacterial infection leading to hospitalization, can lead to improved patient outcomes and cost savings. Why We Must Act Now • The way we use antibiotics today or in one patient directly impacts how effective they will be tomorrow or in another patient; they are a shared resource. • Antibiotic resistance is not just a problem for the person with the infection. Some resistant bacteria have the potential to spread to others—promoting antibiotic-resistant infections. • Since it will be many years before new antibiotics are available to treat some resistant infections, we need to improve the use of antibiotics that are currently available. Healthcare Facility Administrators and Payers • Make appropriate antibiotic use a quality improvement and patient safety priority. • Focus on reducing unnecessary antibiotic use, which can reduce antibiotic-resistant infections, Clostridium difficile infections, and costs, while improving patient outcomes. • Emphasize and implement antibiotic stewardship programs and interventions for every facility—regardless of facility setting and size. • Monitor Healthcare Effectiveness Data and Information Set (HEDIS®) performance measures on pharyngitis, upper respiratory infections, acute bronchitis, and antibiotic utilization. For more information, visit CDC’s Get Smart program website: Get Smart Resources for Healthcare Providers http://www.cdc.gov/getsmart/week/educational-resources/hcp.html Centers for Disease Control and Prevention For more information, please contact Centers for Disease Control and Prevention. 1600 Clifton Road N.E., Atlanta, GA 30333 Telephone: 1-800-CDC-INFO (232-4636)/TTY: 1-888-232-63548 Email: [email protected] Web: http://www.cdc.gov/getsmart W hen your child is sick, you want to do everything you can to help. But antibiotics are not the answer for every illness. This brochure will help you know when antibiotics work – and when they won’t. For more information, talk to your healthcare provider or visit www.cdc.gov/ getsmart. The Risk: Bacteria Become Resistant What’s the harm in giving your child antibiotics anytime? Taking antibiotics when they are not needed can cause some bacteria to become resistant to the antibiotic. These resistant bacteria are stronger and harder to kill. They can stay in your child’s body and can cause severe illnesses that can’t be cured with antibiotics. A cure for resistant bacteria may require stronger treatment – and possibly a stay in the hospital. To help prevent antibiotic resistance, the Centers for Disease Control and Prevention (CDC) recommends giving your child antibiotics only when necessary. Antibiotics Aren’t Always the Answer Most illnesses are caused by two kinds of germs: bacteria or viruses. Antibiotics can cure bacterial infections – not viral infections. Bacteria cause strep throat, some pneumonia and sinus infections. Antibiotics can work. Viruses cause the common cold, most coughs and the flu. Antibiotics don’t work. Using antibiotics for a virus: • Will NOT cure the infection • Will NOT help your child feel better • Will NOT keep others from catching your child’s illness Protect Your Child, Give the Best Care A ntibiotics should not be used to treat the common cold, runny noses and most coughs. Children fight off these viral illnesses on their own. If your child’s healthcare provider prescribes an antibiotic to treat a bacterial infection – like strep throat – be sure to give your child all of the medicine. Only using part of the prescription means that only part of the infection has been treated. Not finishing the medicine can cause resistant bacteria to develop. Talk to Your Healthcare Provider to Learn More ? Commonly Asked Questions: How Do I Know if My Child has a Viral or Bacterial Infection? Ask your child’s healthcare provider and follow his or her advice on what to do about your child’s illness. Remember, colds are caused by viruses and should not be treated with antibiotics. Does This Mean I Should Never Give My Child Antibiotics? Antibiotics are very strong medicines and should be used to treat bacterial infections. Your healthcare provider will prescribe antibiotics if your child has a bacterial infection. If Mucus from the Nose Changes from Clear to Yellow or Green — Does This Mean That my Child Needs an Antibiotic? No. Yellow or green mucus does not mean that your child has a bacterial infection. It is normal for mucus to get thick and change color during a viral cold. FOR PARENTS GET SMART… •Antibiotics are strong medicines, but they don’t cure everything. •When not used correctly, antibiotics can actually be harmful to your child’s health. •Antibiotics can cure most bacterial infections. Antibiotics cannot cure viral illnesses. •Antibiotics kill bacteria – not viruses. •When your child is sick, antibiotics are not always the answer. USE ANTIBIOTICS WISELY Talk with your healthcare provider about the right medicines for your child's health. Snort. Sniffle. Sneeze. No Antibiotics Please. For more information, see the Centers for Disease Control and Prevention website at: www.cdc.gov/getsmart or call 1-800-CDC-INFO Treat colds and flu with care. Talk to your healthcare provider. As a parent, you want to help your child feel better. But antibiotics aren’t always the answer. They don’t fight the viruses that cause colds and flu. What will? Fluids and plenty of rest are best. Talk to your healthcare provider. Find out when antibiotics work—and when they don’t. The best care is the right care. For more information, please call 1-800-CDC-INFO or visit www.cdc.gov/getsmart. CS121386 Treat colds and flu with care. Talk to your healthcare provider. As a parent, you want to help your child feel better. But antibiotics aren’t always the answer. They don’t fight the viruses that cause colds and flu. What will? Fluids and plenty of rest are best. Talk to your healthcare provider. Find out when antibiotics work—and when they don’t. The best care is the right care. For more information, please call 1-800-CDC-INFO or visit www.cdc.gov/getsmart. CS121386 Viruses or Bacteria What's got you sick? Antibiotics only treat bacterial infections. Viral illnesses cannot be treated with antibiotics. When an antibiotic is not prescribed, ask your healthcare professional for tips on how to relieve symptoms and feel better. Illness Usual Cause Antibiotic Viruses Bacteria Needed Cold/Runny Nose NO Bronchitis/Chest Cold (in otherwise healthy children and adults) NO Whooping Cough Yes Flu NO Strep Throat Yes Sore Throat (except strep) NO Fluid in the Middle Ear (otitis media with effusion) NO Urinary Tract Infection Yes Antibiotics Aren’t Always the Answer www.cdc.gov/getsmart U.S. Department of Health and Human Services Centers for Disease Control and Prevention Sept 2014