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The Calculus of Probability Let A and B be events in a sample space S. Partition rule: P(A) = P(A ∩ B) + P(A ∩ B {) Example: Roll a pair of fair dice P(Total of 10) = P(Total of 10 and double) + P(Total of 10 and no double) = 2 3 1 1 + = = 36 36 36 12 Complementation rule: P(A{) = 1 − P(A) Example: Often useful for events of the type “at least one”: P(At least one even number) 9 3 = 1 − P(No even number) = 1 − = 36 4 Containment rule P(A) ≤ P(B) for all A ⊆ B Example: Compare two aces with doubles, 1 6 1 = P(Two aces) ≤ P(Doubles) = = 36 36 6 Calculus of Probability, Jan 26, 2003 -1- The Calculus of Probability Inclusion and exclusion formula P(A ∪ B) = P(A) + P(B) − P(A ∩ B) Example: Roll a pair of fair dice P(Total of 10 or double) = P(Total of 10) + P(Double) − P(Total of 10 and double) = 3 6 1 8 2 + − = = 36 36 36 36 9 The two events are 46, 55, 64} Total of 10 = { and 11,22,33,44,55,66} Double = { The intersection is 55}. Total of 10 and double = { Adding the probabilities for the two events, the probability for the event 55 is added twice. Calculus of Probability, Jan 26, 2003 -2- Conditional Probability Probability gives chances for events in sample space S. Often: Have partial information about event of interest. Example: Number of Deaths in the U.S. in 1996 Cause Heart Cancer HIV Accidents1 Homicide2 All causes 1 All ages 1-4 5-14 15-24 733,125 207 341 920 544,161 440 1,035 1,642 32,003 149 174 420 92,998 2,155 3,521 13,872 24,486 395 513 6,548 2,171,935 5,947 8,465 32,699 Accidents and adverse effects, 2 25-44 45-64 ≥ 65 16,261 102,510 612,886 22,147 132,805 386,092 22,795 8,443 22 26,554 16,332 30,564 9,261 7,717 52 148,904 380,396 1,717,218 Homicide and legal intervention measure probability with respect to a subset of S Conditional probability of A given B ∩ B) P(A|B) = P(A P(B) , If if P(B) > 0 P(B) = 0 then P(A|B) is undefined. Conditional probabilities for causes of death: ◦ P(accident) = 0.04282 ◦ ◦ ◦ P(age=10) = 0.00390 P(accident|age=10) = 0.42423 P(accident|age=40) = 0.17832 Calculus of Probability, Jan 26, 2003 -3- Conditional Probability Example: Select two cards from 32 cards ◦ What is the probability that the second card is an ace? P(2nd card is an ace) = 18 ◦ What is the probability that the second card is an ace if the first was an ace? P(2nd card is an ace|1st card was an ace) = 313 Calculus of Probability, Jan 26, 2003 -4- Multiplication rules Example: Death Rates (per 100,000 people) All Ages 1-4 5-14 15-24 25-44 45-64 ≥ 65 872.5 38.3 22.0 90.3 177.8 708.0 5071.4 Can we combine these rates with the table on causes of death? ◦ What is the probability to die from an accident (HIV)? ◦ What is the probability to die from an accident at age 10 (40)? P(accident|die) = P(die from accident)/P(die) ⇒ P(die from accident) = P(accident|die)P(die) Know Calculate probabilities: ◦ P(die from accident) = 0.04281 · 0.00873 = 0.00037 ◦ ◦ ◦ ◦ ◦ P(die from accident|age = 10) = 0.42423 · 0.00090 = 0.00038 P(die from accident|age = 40) = 0.17832 · 0.00178 = 0.00031 P(die from HIV) = 0.01473 · 0.00873 = 0.00013 P(die from HIV|age = 10) = 0.02055 · 0.00090 = 0.00002 P(die from HIV|age = 40) = 0.15308 · 0.00178 = 0.00027 General multiplication rule P(A ∩ B) = P(A|B)P(B) = P(B|A)P(A) Calculus of Probability, Jan 26, 2003 -5- Independence Example: Roll two dice ◦ What ist the probability that the second die shows 1? P(2nd die = 1) = 61 ◦ What ist the probability that the second die shows 1 if the first die already shows 1? P(2nd die = 1|1st die = 1) = 61 ◦ What ist the probability that the second die shows 1 if the first does not show 1? P(2nd die = 1|1st die 6= 1) = 61 The chances of getting 1 with the second die are the same, no matter what the first die shows. Such events are called independent: The event A is independent of the event B if its chances are not affected by the occurrence of B, P(A|B) = P(A). Equivalently, A and B are independent if P(A ∩ B) = P(A)P(B) Otherwise we say A and B are dependent. Calculus of Probability, Jan 26, 2003 -6- Let’s Make a Deal The Rules: ◦ Three doors - one price, two blanks ◦ Candidate selects one door ◦ Showmaster reveals one loosing door ◦ Candidate may switch doors 1 2 3 Would YOU change? Can probability theory help you? ◦ What is the probability of winning if candidate switches doors? ◦ What is the probability of winning if candidate does not switch doors? Calculus of Probability, Jan 26, 2003 -7- The Rule of Total Probability Events of interest: ◦ A - choose winning door at the beginning ◦ W - win the price Strategy: Switch doors (S) PS (W |A) = 0 ◦ PS (A) = 13 ◦ PS (W |A{) = 1 ◦ PS (A{) = 32 Probability of interest: PS (W ): PS (W ) = PS (W ∩ A) + PS (W ∩ A{) = PS (W |A)PS (A) + PS (W |A{)PS (A{) Know: ◦ =0· 1 + 1 · 32 = 3 2 3 Strategy: Do not switch doors (N ) PN (W |A) = 1 ◦ PN (A) = 13 ◦ PN (W |A{) = 0 ◦ PN (A{) = 23 Probability of interest: PN (W ): PN (W ) = PN (W ∩ A) + PN (W ∩ A{) = PN (W |A)PN (A) + PN (W |A{)PN (A{) Know: ◦ =1· 1 + 0 · 23 = 3 Calculus of Probability, Jan 26, 2003 1 3 -8- The Rule of Total Probability Rule of Total Probability If B1, . . . , Bk mutually exclusive and B1 ∪ . . . ∪ Bk = S, then P(A) = P(A|B1)P(B1) + . . . + P(A|Bk )P(Bk ) Example: Suppose an applicant for a job has been invited for an interview. The chance that ◦ he is nervous is P(N ) = 0.7, P(S|N ) = 0.2, the interview is succussful if he is not nervous is P(S|N {) = 0.9. ◦ the interview is succussful if he is nervous is ◦ What is the probability that the interview is successful? P(S) = P(S|N )P(N ) + P(S|N {)P(N {) = 0.2 · 0.7 + 0.9 · 0.3 = 0.441 Calculus of Probability, Jan 26, 2003 -9- The Rule of Total Probability Example: Suppose we have two unfair coins: ◦ Coin 1 comes up heads with probability 0.8 ◦ Coin 2 comes up heads with probability 0.35 Choose a coin at random and flip it. What is the probability of its being a head? Events: H=“heads comes up”, C1=“1st coin”, C2=“2nd coin” P(H) = P(H|C1)P(C1) + P(H|C2)P(C2) 1 = (0.8 + 0.35) = 0.575 2 Calculus of Probability, Jan 26, 2003 - 10 - Bayes’ Theorem Example: O.J. Simpson “Only about 1 10 of one percent of wife-batterers actually murder their wives” Lawyer of O.J. Simpson on TV Fact: Simpson pleaded no contest to beating his wife in 1988. So he murdered his wife with probability 0.001? ◦ Sample space S - married couples in U.S. in which the husband beat his wife in 1988 ◦ Event H - all couples in S in which the husband has since murdered his wife ◦ Event M - all couples in S in which the wife has been murdered since 1988 We have ◦ ◦ ◦ P(H) = 0.001 P(M |H) = 1 since H ⊆ M P(M |H {) = 0.0001 at most in the U.S. Then P(H) P(H|M ) = P(MP|H) (M ) P(M |H)P(H) = P(M |H)P(H) + P(M |H {)P(H {) = 0.001 = 0.91 0.001 + 0.0001 · 0.999 Calculus of Probability, Jan 26, 2003 - 11 - Bayes’ Theorem Reversal of conditioning (general multiplication rule) P(B|A)P(A) = P(A|B)P(B) Rewriting P(A) using the rule of total probability we obtain Bayes’ Theorem P(B|A) = P(A|B)P(B) P(A|B)P(B) + P(A|B {)P(B {) If B1, . . . , Bk mutually exclusive and B1 ∪ . . . ∪ Bk = S, then i )P(Bi ) P(Bi|A) = P(A|B )P(BP(A|B ) + . . . + P(A|B )P(B ) 1 1 k k (General form of Bayes’ Theorem) Calculus of Probability, Jan 26, 2003 - 12 - Bayes’ Theorem Example: Testing for AIDS Enzyme immunoassay test for HIV: ◦ P(T+|I+) = 0.98 (sensitivity - positive for infected) ◦ ◦ P(T-|I-) = 0.995 (specificity - negative for noninfected) P(I+) = 0.0003 (prevalence) What is the probability that the tested person is infected if the test was positive? P(I+) P(I+|T+) = P(T+|I+)PP(T+|I+) (I+) + P(T+|I-)P(I-) = 0.98 · 0.0003 0.98 · 0.0003 + 0.005 · 0.9997 = 0.05556 Consider different population with P(I+) = 0.1 (greater risk) 0.98 · 0.1 = 0.956 P(I+|T+) = 0.98 · 0.1 + 0.005 · 0.9 testing on large scale not sensible (too many false positives) Repeat test (Bayesian updating): ◦ P(I+|T++) = 0.92 in 1st population ◦ P(I+|T++) = 0.9998 in 2nd population Calculus of Probability, Jan 26, 2003 - 13 -