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Introduction Dear friends: With generations of development and prosperous social economy, people’s life style and dietary habit have changed significantly which results in the prevalence of chronic diseases such as high blood pressure, kidney disease, diabetes, and hyperuricemia. The improvement of medicine is not merely for pursuing the extension of life but also for a better quality of life and living; therefore, preventive medicine has become the highlight of the health medicine nowadays. Kidney disease is not only an idiopathic kidney disease but also a complication of diabetes and high blood pressure. Correct prevention countermeasures can avoid the incidents of kidney disease. Since kidney disease lacks of distinct symptoms in the early stage, many friends are unaware of their disease or take secret recipes or prescriptions from hearsays and induce the deterioration of the disease. Kidney disease can in fact be well controlled if taking correct preventive measures or being diagnosed and treated correctly at an early stage. How much do you know about kidney functions? Are you aware of the tests on kidney functions? How to find out if you have kidney disease? How to prevent kidney disease on a regular basis? To enhance the public’s awareness of new information, we have once again invited expert scholars to complete the “Kidney care- How to care for your kidney” in the hope that the public will learn the tips of kidney care and the incidents of kidney disease will be reduced. Care for your “kidney” on a regular basis will guarantee a healthy life. Bureau of Health Promotion,Department of Health, R.O.C.(Taiwan) Best regards, Mei-Ling Hsiao Director General Table of Contents 1. Where are the kidneys? The location of the kidneys The structure of the kidneys 2. What are the functions of the kidneys? To excrete waste products To regulate water level To balance PH levels and electrolyte concentrations To secrete hormones 3. Why do kidneys fail? The cause and types of renal disease The high-risk groups for renal disease 4. How to know when the kidneys have problems? Changes in urine Physical symptoms 5. Medical tests to detect renal disease Urine Test Blood Test X–Ray Exam Ultrasound Scan 6. How can one effectively prevent renal disease? Tip 1–Healthy lifestyle Tip 2–Eat carefully Tip 3–Drink enough water and don’t store up urine in the bladder Tip 4–Always seek professional medical help and avoid drug Tip 5–Self-monitoring and health checkups Tip 6–Disease treatment and control 7. Q & A Where are the kidneys? The location of the kidneys 1 The kidneys in humans are located in the posterior part of the abdomen and under the lower border of the lowest ribs. There is one on each side of the spine. Left Kidney Right Kidney Abdominal cavity ureter Bladder Urethra 2 Each kidney resembles the shape of a broad bean and its size is equal to a fist. 3 Each kidney weighs about 125-150 grams My size is equal to a fist. How to take care of Your Kidneys The Structure of the Kidneys A nephron is the basic structural unit of the kidneys. There are about one million nephrons in each kidney. A nephron consists of a glomerulus (a very small artery ) and a renal tubule. Its chief function is to regulate body water level,electrolytes and metabolic wastes by filtering the blood flowing into the glomerulus, then excreting them as urine. Browman’s Capsule Renal Calyx Glomerulus Renal Vein Ureter Cortex Renal Medulla Bureau of Health Promotion,Department of Health,R.O.C.(Taiwan) Caring for You What are the functions of the kidneys? To excrete waste products The waste products in your blood come from the foods you eat and the metabolites of your body. Kidneys excrete them in the urine. To regulate water level Kidneys can remove excess water from the blood as urine. Two kidneys are able to produce 1000-2400 c.c. urine a day. To balance PH levels and electrolyte concentrations The kidneys regulate the blood concentration of electrolytes, such as calcium, sodium (salt), phosphates and potassium and the blood PH level within the normal ranges. To secrete hormones 1 Secrete renin, which regulates blood pressure. 2 Secrete erythropoietin, which stimulates the production of red blood cells. 3 Activate vitamin D, which helps to maintain the density and health of bones. To excrete waste products To regulate water level To balance PH levels and electrolyte concentrations To secrete hormones How to take care of Your Kidneys Why do kidneys fail? The etiology and types of kidney disease 1 Glomerular diseases, which include two categories: per ten sio Go n ut Ki d Ki ney dn ey stone tum s ors Hy ritis neph erulo Glom 1.Primary glomercular disorder:e.g., chronic glomerulonephritis 2.Secondary glomercular disorder: e.g., kidney disease induced by hypertension, diabetes or systemic lupus erythematosus (SLE). 2 Tubulo-interstitial diseases: e.g., chronic pyelonephritis , long-term use of painkillers, kidney stones, kidney tumors, urethral or ureteral strictures and gout. 3 Vascular nephropathy: e.g., vasculitis , hypertensive renal arteriosclerosis 4 Congenital kidney diseases: e.g., polycystic kidney disease (PKD), which is a genetic disorder and the most common one in this classification . Diabetes Systemic lupus erythematosus Bureau of Health Promotion,Department of Health,R.O.C.(Taiwan) Caring for You The high-risk groups for renal disease 1 Patients with diabetes High blood sugar induces small artery and large artery complications, which will decrease the blood flow of kidneys and eventually affect kidney functions. 2 Patients with hypertension High blood pressure can easily injure renal vessels and, as a result, compromises the kidneys’ ability to excrete waste and regulate body water 3 Patients with gout High serum uric acid can make uric acid crystallize in the joints as well as in the kidneys, thereby affecting renal functions. 4 Those with a family history of kidney disease If any of your grandparents, parents, uncles, aunts or siblings has kidney disease, you belong to the high-risk group. 5 The Elderly Usually, the function of the kidneys decreases gradually as one’s age increases. So those who aged over 65 are more likely to suffer impairment of the renal functions. 6 Those with a history of drug abuse Individuals with a long history of drug abuse, such as taking anti-inflammatory drugs or painkillers without medical approval or herbs from unknown sources,especially aristolochia fangchi wu, which contains, aristolochic acid are in danger of damaging their kidneys. How to take care of Your Kidneys The risk factors of renal disease Obesity High-sodium diet Hyperlipidemia H so igh y- -s be od an iu sa m uc e Drugs Alcohol Smoking Beer Help! Alc oho l Taking unknown traditional Chinese medicine or herbal medicine will cause the toxicity in the kidneys. Bureau of Health Promotion,Department of Health,R.O.C.(Taiwan) Caring for You How to know when the kidneys have problems? The early stages of renal disease have no obvious symptoms. Kidney diseases commonly manifest themselves by proteinuria, hematuria (blood in the urine), frequent voiding, oliguria and edema. Changes in urine 1 Increased frequency of urination: Frequent voiding, nocturia (increased voiding frequency at night resulting from increased amounts of night urine). 2 Burning sensations during urination: Experiencing burning sensations or pain while voiding. 3 Foam in the urine (proteinuria): A thick layer of foam on the urine surface that lasts for a long time. 4 Any change in the color or amount of urine: Hematuria or low-urine output Hematuria Physical symptoms 1 Edema: Lower limbs start to swell and a skin indentation forms when pressed down by the fingers. The skin indentation remains some time after withdrawing the fingers. Proteinuria 2 Rapid increase in body weight: The average of increased body weight more than 0.5 kg per day 3 Lower back and abdominal pain: Pain in the lower back, back or lower abdomen caused by unknown reasons. 4 High blood pressure, anemia, skin itchiness and general malaise How to take care of Your Kidneys Skin itchiness vascular sclerosis Heart Failure Edema •If you experience the aforementioned symptoms, visit your family doctor, internist or nephrologist for a further check-up. Bureau of Health Promotion,Department of Health,R.O.C.(Taiwan) Caring for You Medical tests to detect renal disease Urine Test 1 Protein (proteinuria ): Protein in the urine may suggest that the kidneys are damaged. Two plus tests taken within a few weeks suggest a permanent proteinuria, which is a sign of chronic kidney disease. Proteinuria is also an early sign of diabetic nephropathy. 2 Red or white blood cells: Normally, few or no blood cells are found in the urine. If the number of blood cells is abnormally high in a urine test, it may be a warning sign of a kidney or urinary tract disorder. 3 Glucose: If glucose is found in the urine, a blood test should be arranged to confirm whether the blood sugar level or only the sugar in the urine is abnormal. 4 Urine samples collected over a period of 24 hours: the total amount of urine within 24 hours can be used to calculate the filtration rate of the Glucose test strip renal glomerulus and Blood urine test strip therefore to predict how the kidneys are Protein test strip functioning. How to take care of Your Kidneys Blood test for creatinine Creatinine is a waste product generated from the metabolism of muscle. The kidneys eliminate blood creatinine through the urine. Therefore, when the kidneys are damaged, creatinine accumulates in the blood. (Normal levels of blood creatinine: 0.7-1.2 mg/dl) X-Ray Exam X –Ray Exam: They can be used to assess the shape, location and size of the kidneys. They can also detect the presence of calculi (stones) in the kidneys. Ultrasound Scan A kidney ultrasound scan can detect the size of the kidneys (oversized or atrophic), kidney stones, tumors and changes of related structures, such as the ureters. Although Chronic kidney disease is often associated with atrophic kidneys, the kidney sizes from diabetic nephropathy, polycystic kidney disease or amyloidosis are usually not atrophic. Bureau of Health Promotion,Department of Health,R.O.C.(Taiwan) Caring for You How can one effectively prevent renal disease? To keep your kidneys healthy, maintain a healthy lifestyle. Here are a few tips: Tip 1—A Healthy lifestyle 1 Keep your body weight within an optimal range BMI (Body Mass Index)=body weight(kg)/body height squared(m²) (Normal: 18-24) For example: The BMI of a person with a body height of 162cm and a body weight of 60 kg is 162 cm=1.62m 60/(1.62x1.62)=22.86 (Normal) 2 Exercise regularly: Choose the exercise that appeals to you, such as walking, dancing or Chi-kung, and do it with a minimum of 20-30 minutes each time and at least three times a week. You can increase the frequency gradually depending on your physical fitness. 3 Quit smoking and avoid heavy drinking: P a t ients w ith d ia b e te s o r gout should avoid alcohol completely. 4 Maintain a healthy lifestyle: Try not to stay up all night if possible, and reserve time for rest and leisure activities. How to take care of Your Kidneys Tip 2 –Eat Carefully 1 A balanced diet is the golden rule. Additional supplements or special dietary treatment is not necessary. Eat foods from all the six basic food groups. A sufficient nutritional intake can help to boost the immune system and avoid infections. Cut down on red meat, foods made from potatoes or refined grains 1-2 serving of dairy products a day 0-2 serving of fish, poultry and eggs a day 1-2 serving of nuts and beans a day Lots of vegetables and 2-3 serving of fruit a day More whole grains and vegetable oil Daily exercise to control body weight Bureau of Health Promotion,Department of Health,R.O.C.(Taiwan) Caring for You 2 Consume appropriate amount of protein, avoid excessive meat consumption The metabolism of dietary protein produces nitrogenous waste, which is removed by the kidneys from the body. An excessive intake of animal protein from fish, meat, eggs or dairy products will elevate the blood lipid level, which may lead to kidney vascular disorders. 3 Less salt, less seasoning and less processed food Use pickled or salted food products, concentrated ingredients, sauces or condiments (fermented tofu, pickled squash, chili bean sauce, ketchup or barbecue sauce) sparingly. Long-term highsodium diet should be avoided to lessen the burden on the kidneys. Choose fresh ingredients with spices such as green onion, ginger, garlic, chili, lycium Chinense, or Chinese basil to compensate for the low salt in the foods you eat. Protection of the kidneys starts with a balanced diet. A highfiber, low-fat, lowsodium, additive-free, fresh and natural diet is the best choice! Select from all the food groups and you won’t need extra dietary supplements. Also remember to maintain your optimal body weight. Nutr ition How to take care of Your Kidneys Tip 3—Drink enough water and don’t store up urine in the bladder 1 Drink enough water Water helps the excretion of wastes and urinary calculi. One should drink 1600-2000 cc of water per day unless there are preexisting conditions against such a recommendation (such as suffering from edema caused by cardiovascular diseases, kidney disease or liver cirrhosis. Patients with edema should consult their doctors about the recommended daily amount of water intake). The elderly are advised to avoid excessive water intake at night for a better sleep. 2 Don’t store up urine in the bladder You should go to the toilet when you feel like voiding. This can reduce the chances of urinary tract infection caused by overexpansion of the bladder. W.C Cleaning Bureau of Health Promotion,Department of Health,R.O.C.(Taiwan) Caring for You Tip 4—Always seek professional medical help and avoid drug abuse Always seek guidance from a medical professional before taking medicines. Avoid overusing painkillers, drugs from unknown sources, unproven portions or prescription-free medicines, which claim exaggerated results. Professional medical service See a qualified doctor. Take your medcine by the prescription. Unknow ingredients How to take care of Your Kidneys Tip 5—Self-monitoring and health checkups 1 Observe changes in the urine Changes in urination habit Pay attention to an obvious increase of voiding frequency and changes in urine output. Also, be alert when frequent voiding at night starts to affect your sleep quality. Changes in the appearance of urine Changes in the color and quality of urine , e.g., hematuria( red blood cells in the urine) , foam in the urine, etc. If any change in the urine is noted, you are advised to consult your physician for early detection of kidney disease. 2 Regular health checkups National Health Insurance in Taiwan offers regular health checkups for adults aged 40 and over, once every three years for those aged 40-64 and once per year for those aged 65 and over. A routine health checkup can detect the early signs of kidney disease and help with early treatment, if necessary. Healt h Examin ation Service Center Bureau of Health Promotion,Department of Health,R.O.C.(Taiwan) Caring for You Tip 6—Disease treatment and control Primary glomerulonephritis requires long-term monitoring Glomerulonephritis accounts for the majority of dialysis patients in Taiwan. A regular health checkup can detect the early signs of the disease. Long-term treatment and follow-up will avoid deterioration of the renal functions. ent atm Tre plan Prescri ption Pay attention to physical symptoms. The majority of acute renal diseases are curable. How to take care of Your Kidneys 1 Blood sugar control As the kidneys are mainly composed of tiny vessels, vascular diseases within the organ caused by high blood sugar will have an impact on the renal functions. To detect the early signs of kidney or cardiovascular disease, patients with diabetes should have regular microalbuminuria tests. Ideal blood sugar level before eating <110mg/dl Ideal blood sugar level after eating < 140mg/dl Glycated hemoglobin(HbA1c) < 7.0% (HbA1c shows the average blood sugar control over the past two-three months) 2 Blood pressure control High blood pressure can easily damage renal vessels, thereby impairing the kidneys’ functions of waste excretion and body water regulation. Ideal systolic blood pressure < 130 mmHg Ideal diastolic blood pressure < 80mmHg Health recording table Blood sugar Before eating 90 After eating Blood pressure systolic blood pressure ar meter Blood sug 110 diastolic blood pressure Bureau of Health Promotion,Department of Health,R.O.C.(Taiwan) Caring for You 3 Uric acid control for gout patients For gout patients, a high blood concentration of uric acid will crystallize in the kidneys, affecting renal functioning. Patients with gout should control high blood uric acid in order to protect their kidneys through diet and medication. Controlling blood pressure and blood sugar is one of the ways to prevent the renal functions from deteriorating and the need for kidney dialysis. How to take care of Your Kidneys Q& A Q Do steroids affect the kidneys? prescribed by your doctor to treat some types of A Steroids chronic kidney disease, especially those related to immune disorders, and will improve the disease status. Kidney function deterioration is not resulted from steroids but the progress of the disease. Q What does bloody urine (hematuria) mean? causes of hematuria can be infections or calculi in the A The urinary system (kidneys, ureter, bladder and urethra) or tumors. Further examinations are needed to confirm the diagnosis. Q Is lower back pain a warning sign of kidney disease? posture or spinal disease may result in soreness A Improper and pain in your lower back muscles on both sides; therefore, it is recommended that you should visit a nephrologist for further examination. foaming urine (protein urine) mean that the kidney Q Does function is impaired? is not certain.Foaming urine may be related to high urine A Itprotein , but other situations may also cause foaming urine. So further examination is needed to confirm the exact cause. Bureau of Health Promotion,Department of Health,R.O.C.(Taiwan) Caring for You Q I am young and fit, should I worry about kidney diseases? diseases can occur in young people. If you have A Kidney unhealthy dietary habits or an unhealthy lifestyle, indulge frequently in excessive eating and drinking or take medicines from unknown sources, your kidneys will be more susceptible to impairment. Q How do I know if I have kidney disease? manifestations of kidney disease include proteinuria, A The hemtauria, l o w e r l i m b s w e l l i n g o r s w o l l e n f a c e , hypertension, anemia, skin itchiness and loss of appetite. When you experience 2-3 of the aforementioned manifestations, you should see your doctor for a blood and urine test. However, some renal disorders do not have any of these manifestations in the early stage. In these cases, a routine health checkup or simple urine and blood test can help to detect them in the early stage. Q Does kidney disease imply “impotence”? A Most people consider these two terms to be the same. In fact, kidney disease suggests damaged renal tissues or impaired kidney function and has nothing to do with the “impotence” defined in Chinese medicine. Q Does dark colored first urine upon waking up in the morning suggest abnormal kidney function? How to take care of Your Kidneys A Kidneys can produce concentrated urine. Normally, the amount of urine produced decreases at night during sleeping hours, and your voiding frequency drops accordingly and so the urine color becomes darker. Q When blood pressure is under control, should we stop A taking hypertension drugs to prevent from damaging the kidneys? Blood pressure should be controlled below 130/80mmHg. Blood pressure fluctuation will speed up damage to the kidney vessels. Therefore, it is not a good idea to stop taking hypertension drugs at your own discretion. You should follow your doctor’s instructions for decreasing or adjusting your medication. Q Is low-sodium salt better for the kidneys? A Low-sodium salt replaces part of the sodium content with potassium. An excessive intake of it can still burden the kidneys. Following the dietary principle of less salt and less seasoning is more important for kidney protection. Lowsodium salt is not really helpful in keeping your kidneys healthy. Q How can one avoid excessive protein intake? recommended daily amount of protein for a healthy A The individual is 4 to 6 servings (1 serving= 37.5g). Bureau of Health Promotion,Department of Health,R.O.C.(Taiwan) Caring for You A hand-sized pork fillet contains about 3 portions of protein. A palm-sized cod fillet contains 2 portions. A chicken drumstick has 2 portions. A standard cube of Tofu has 1 portion. One egg equals 1 portion. A glass of milk (240cc) is about 1 portion. Q How can one follow a kidney-friendly diet when eating out most of the time? A The key is to have a balanced diet! If a dish looks too greasy or has too much seasoning (such as fried beef with green onions), try not to eat all of the oil or sauce. Rinsing it with hot water before eating is a simple way to help you to cut down on your intake of salt and fat. Of course, you can also ask the cook to reduce the amount of seasoning. Q What will happen if a person only has one kidney? kidney will compensate and increase its function. A AA single person can live a normal life even with just one kidney. The same rules of less salt, less fat, moderate eating, regular urine tests and blood tests apply.