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Tomsk Cancer Research Institute Tomsk State University University of Heidelberg, Germany Technology Platform “Medicine of the Future” By support Russian Foundation for Basic Research (RFBR) The European Molecular Biology Organization (EMBO) EMBO WORKSHOP «CELLULAR AND MOLECULAR MECHANISM OF TUMOUR MICROENVIRONMENT CROSSTALK» 9 – 12 JULY 2015 | TOMSK, RUSSIA Scientific Program GENERAL INFORMATION This Workshop is being held at the National Research Tomsk State University (TSU), located in the heart of the Tomsk. Workshop locations address DAY 1 – 09.07.2015 – 34A Lenin avenue, TSU Research Library- 7 and 36 Lenin avenue, TSU Main Building –(1 (social events) DAY 2-3 – 10.07.-11.07.2015 – 34A Lenin avenue, TSU Research Library- 7 Scientific Committee Julia Kzhyshkowska, Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University; Heidelberg, Germany Evgeny L. Choynzonov, Tomsk Cancer Research Institute, Tomsk, Russia Eduard V. Galazhinsky, National Research Tomsk State University, Tomsk, Russia Feodor L. Kisseljov, Research Institute of Carcinogenesis, N.N. Blokhin Cancer Research Center, Moscow, Russia Evgeny N. Imyanitov, N.N. Petrov Institute of Oncology, Sent-Petersburg, Russia Valery P. Puzyrev, Research Institute of Medical Genetics, Tomsk, Russia Mikhail I. Voevoda, Research Institute of Therapy and Preventive Medicine, Novosibirsk, Russia Nadezda V. Cherdyntseva, Tomsk Cancer Research Institute, Tomsk, Russia; National Research Tomsk State University, Tomsk, Russia Mikhail A. Krasilnikov, N.N. Blokhin Cancer Research Center, Moscow, Russia Marianna G. Yakubovskaya, Research Institute of Carcinogenesis, N.N. Blokhin Cancer Research Center, Moscow, Russia Contact information Tomsk Cancer Research Institute 5 Kooperativny Street 634050, Tomsk, Russia www.oncology.tomsk.ru National Research Tomsk State University 36 Lenin Avenue 634050, Tomsk, Russia www.tsu.ru DAY 1 - 09.07.2015 34A Lenin avenue, TSU Research Library Registration 15.00-16.30 Welcome Remarks and Opening Ceremony 16.30-17.00 17.00-17.30 Coffee break 17.30-18.30 Keynote Lecture 19.00-21.30 Welcome reception ( 36 Lenin TSU main building) DAY 2 - 10.07.2015 34A Lenin avenue, TSU Research Library Section 1 09.00-10.30 Invited Lectures 10.30-10.50 Coffee break 10.50-12.15 Invited Lectures 12.15-13.00 Short talk/ Short talk of young investigator 13.00-13.10 Discussion 13.10-14.00 14.00-15.00 Lunch Poster Session 1 Section 2 15.00-15.45 Invited Lecture 15.45-16.20 Short talk/ Short talk of young investigator 16.20-16.50 Coffee break 16.50-18.50 Short talk/ Short talk company 18.50-19.10 Discussion 19.10-21.30 DAY 3 - 11.07.2015 Evening city tour 34A Lenin avenue, TSU Research Library Section 3 9.00-9.45 Invited Lecture 9.45-10.50 Short talk/ Short talk of young investigator 10.50-11.10 Coffee break 11.10-12.20 Short talk/ Short talk of young investigator 12.20-12.30 Discussion 12.30-13.30 13.30-14.30 Lunch Poster Session 2 Section 4 14.30-16.00 Invited Lecture 16.00-16.30 Coffee break 16.30-18.55 Short talk/ Short talk of young investigator Discussion Closing Dinner 19.10-22.00 (on the premises of the Celebration Hall, 36 Eniseyskay street) DAY 4 - 12.07.2015 Departure 18.55-19.10 DAY 1 (09.07.2015) – 34A Lenin avenue, TSU Research Library Registration (15.00-16.30) Welcome Remarks (16.30-16.45) Chairmen: Professor Eduard V. Galazhinsky Governor of Tomsk region, Sergey Zhvachkin; Rector of Tomsk State University, Professor Eduard V. Galazhinsky; Director of Tomsk Cancer Research Institute, Academician of RAN, Professor Evgeny L. Choynzonov Opening Ceremony (16.45-17.00) Moderated by Professor. Dr. Julia Kzhyshkowska Governor of Tomsk region, Sergey Zhvachkin; Rector of Tomsk State University, Professor Eduard V. Galazhinsky; Director of Tomsk Cancer Research Institute, Academician of RAN, Professor Evgeny L. Choynzonov Coffee break (17.00-17.30) Oral Session Program Chairmen: Prof. Dr. Julia Kzhyshkowska Keynote Lecture (17.30-18.30): Professor Harald zur Hausen (Germany Cancer Research Centre, Heidelberg, Germany) - “The Search for Viruses in Human Cancer and Chronic Diseases” Welcome reception (open to all registered persons, 19.00-21.30) 36 Lenin avenue, TSU Main Building DAY 2 (10.07.2015) – 34A Lenin avenue, TSU Research Library Section 1. Immune system and inflammation: role in tumor development. Tumor microenvironment (9.00-13.00) Chairmen: Prof. Mikhail A. Krasilnikov, Prof. Dr. Julia Kzhyshkowska, Prof. Peter Chumakov Invited Lecture (9.00-9.45): Professor Ron N. Apte (Faculty of Health Sciences and The Cancer Research Center, Ben-Gurion University of the Negev Beer-Sheva, Israel) - “Cytokine regulation of tumor microenvironment” Invited Lecture (9.45-10.30): Professor Siamon Gordon (University of Oxford, UK) - “Macrophage heterogeneity in its normal and pathological microenvironment” Coffee break (10.30-10.50) Chairmen: Prof. Günter Hammerling, Prof. Nadezhda Cherdyntseva, Prof. Fiodor Kisselev Invited Lecture (10.50-11.35): Professor Ethel-Michelle de Villiers (Germany Cancer Research Centre, Heidelberg, Germany) - “Diversity of circular single-stranded DNA viruses and their relationship to human disease” Invited Lecture (11.35-12.20): Professor Michael Kirschfink (University of Heidelberg, Germany) “Complement system in anti-tumor response: mechanisms and therapeutic strategies” Short talk (12.20-12.35): Professor Mikhail A. Krasilnikov (N.N. Blokhin Cancer Research Center, Moscow, Russia) - “The role of cell-cell interactions in the maintaining of autonomous growth and formation of the resistant phenotype of tumor cells” Short talk of young investigator (12.35-12.45): Dmitry Zinovkin (Gomel State Medical University, Gomel, Belarus) - “The immune and vascular components of microenvironment in prognosis of the endometrioid endometrial adenocarcinoma” Short talk of young investigator (12.45-12.55): Anastasia Suhovskih (Institute of Molecular Biology and Biophysics, Novosibirsk, Russia) - “An important role of proteoglycans in the interactions of normal and cancer prostate cells with fibroblasts” Short talk (12.55-13.05): Olga Bajenova (Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University, Russia) - “Effect of carcinoembryonic antigen production by colorectal cancer cells on tumor microenvironment and cancer progression” Discussion by participants (13.05-13.10) Lunch (13.10 – 14.00) Poster Session 1 (14.00-15.00) Section 2. Bacterial and viral pathogen contribution to tumor microenvironment (15.00-19.00) Chairmen: Prof. Siamon Gordon, Dr. Alexei Gratchev, Dr. Anna Zajakina Invited Lecture (15.00-15.45): Professor Peter Chumakov (Engelhardt Institute of Molecular Biology, Moscow, Russia) - “Targeting cancer by viruses” Short talk (15.45-16.10): Professor Evgeny N. Imyanitov (N.N. Petrov Institute of Oncology, St. Petersburg, Russia) – “Hereditary cancer syndromes in Russia” Short talk company (16.10-16-20): Marina Wiklander (Sigma Aldrich) - Next Generation Gene Editing and Gene Silencing Technologies Coffee break (16.20-16.50) Short talk (16.50-17.15): Professor Feodor L. Kisseljov (Research Institute of Carcinogenesis, N.N. Blokhin Cancer Research Center, Moscow, Russia) -“Epigenetic changes in human cervical carcinoma associated with viral-induced pathogenesis” Short talk (17.15-17.35): Dr. Tatyana Isayeva (University of Alabama at Birmingham.) - “Human papilloma virus association with survival of head and neck cancer patients” Short talk (17.35-17.55): Dr. Anna Zajakina (Latvian Biomedical Research and Study Centre, Riga, Latvia) - “Advances in Alpha virus-based anti-cancer therapy” Short talk 17.55-18.10): Dr. Pavel P. Laktionov (Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia) - “Non-invasive, circulating nucleic acids-based tumor diagnostics: looking for epigenetic markers” Short talk company (18.10-18.20): Dr. Bjoern Biedermann (Life Technologies, USA) - “Advantages of acoustic focusing in flow cytometry and state of the art microscopy on your bench” Short talk company (18.20-18.30): Dr. Pavel Natalin (Thermo Fisher Scientific Inc, USA) “LiquidBiopsy ™Platform: highly multiplexed molecular analysis of CTCs, cfDNA, and germline DNA” Short talk company (18.30-18.40): Marina Prokhorova (Merck Millipore, USA) - “Cancer RNA detection in live cells with SmartFlare™ RNA detection probes” Short talk company (18.40-18.50): Dmitry Kvon (Agilent Technologies, USA) - “Agilent target enrichment technology for next-generation sequencing. New application for oncology” Short talk company (18.50-19.00): Anna Voitovich (ОPТEК) – “WAVE System – Mutation screening by DHPLC in gene diagnostic of oncological diseases” Discussion by participants (19.00-19.10) Evening city tour (19.15-21.15) DAY 3 (11.07.2015) – 34A Lenin avenue, TSU Research Library Section 3. Immune system and inflammation in tumor invasion and metastasis. Metastatic nishes (9.00-12.30) Chairmen: Professor Vessela Kristensen, Professor Evgeny N. Imyanitov, Dr. Marianna G. Yakubovskaya Invited Lecture (9.00-9.45): Professor Julia Kzhyshkowska (Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University; Heidelberg, Germany) “Macrophage plasticity and perspectives for their reprogramming in tumor microenvironment” Short talk (9.45-10.00): Professor Ospan A Mynbaev (Moscow Institute of Physics and Technology, Dolgoprudny, Russia; Ghent University, Ghent, Belgium) - “An oxidative stress during laparoscopic surgery is a possible triggering factor of cancer cell metastasis” Short talk (10.00-10.20): Dr. Vladimir Ryabov (University of Heidelberg, Medical Faculty Mannheim, Heidelberg, Germany) - “Role of M2 marker stabillin-1 in tumor progression” Short talk of young investigator (10.20-10.30): Zahid Pranjol (Institute of Biomedical and Clinical Scince, University of Exeter Medical School, UK) - “Tumour secreted factors cathepsins D and L induce pro-angiogenic changes in human omental microvascular endothelial cells (HOMECs) in ovarian cancer metastasis” Short talk of young investigator (10.30-10.40): Amulang Shikeeva (Research Centre for Medical Genetics, Moscow) - “Allelic imbalance and epigenetic changes as a marker of tumor spreading into the adjacent tissue” Short talk of young investigator (10.40-10.50): Geok Choo Sim (UT MD Anderson Cancer Center, USA) - “Comprehensive flow cytometry tracking of regulatory T cells and other lymphocyte subsets during HD IL-2 therapy for melanoma” Coffee break (10.50-11.10) Short talk (11.10-11.30): Dr. Antonina Y. Alexandrova (N.N. Blokhin Cancer Research Center, Moscow, Russia) - “The plasticity of tumor cell migration mechanisms as the adaptive factor, increasing metastasis efficiency” Short talk of young investigator (11.30-11.45): Evgeny Denisov (Tomsk Cancer Research Institute; Laboratory for translational cellular and molecular biomedicine, Tomsk State University, Tomsk, Russia) – “Intratumor morphological heterogeneity of breast cancer as a reflection of cancer invasion patterns: clinical significance and genetic portrait“ Short talk of young investigator (11.45-12.00): Dr. Evgeniya V. Kaigorodova (Department of Pathological Anatomy and Cytology, Cancer Research Institute; Laboratory for translational cellular and molecular biomedicine, Tomsk State University, Tomsk, Russia) - “Circulating tumor cells and bone marrow progenitor cells in the blood of breast cancer patients in the dynamics of neoadjuvant chemotherapy” Short talk (12.00-12.15): Professor Tatiana Ruksha (Krasnoyarsk State Medical University, Krasnoyarsk, Russia) - “MicroRNA signature differs in melanoma microenvironment and tumor cells” Short talk of young investigator (12.15-12.25): Grigory Raskin (Russian Scientific Center of Radiological and Surgical Technologies, St. Petersburg, Russia) - “Morphologic evaluation of prognostic factors in colon adenocarcinoma” Discussion by participants (12.25-12.30) Lunch (12.30 – 13.30) Poster Session 2 (13.30-14.30) Section 4. Molecular markers and targets for cancer therapy. Microenvironment reprogramming as the innovative approach to cancer therapy (14.30-19.00) Chairmen: Professor Michael Kirschfink, Dr. Antonina Y. Alexandrova Invited Lecture (14.30-15.15): Professor Vessela Kristensen (Institute for Cancer Research, University Hospital, Oslo, Norway) - “Integrated genomic analyses of breast cancer, relevance for better prognosis and treatment evaluation” Invited Lecture (15.15-16.00): Professor Günter Hammerling (German Cancer Research Centre (DKFZ), Heidelberg, Germany) - “Strategic manipulation of the microenvironment for efficient immunological cancer therapy” Coffee break (16.00-16.30) Short talk (16.30-16.50): Dr. Maxim Freidin (National Heart and Lung Institute, Imperial College London, UK) - “Blood-based biomarkers for lung cancer” Short talk (16.50-17.10): Dr. Marianna G. Yakubovskaya (Research Institute of Carcinogenesis, N.N. Blokhin Cancer Research Center, Moscow, Russia) - “Epigenetic xenobiotics as factors, increasing efficiency of antitumor drugs” Short talk (17.10-17.30): Dr. Alexei Gratchev (Research Institute of Carcinogenesis, N.N. Blokhin Cancer Research Center, Moscow, Russia; University of Heidelberg, Germany) - “Development of innovative technologies for anti-cancer drug delivery” Short talk (17.30-17.50): Professor Nadezda V. Cherdyntseva (Laboratory of Molecular Oncology and Immunology, Tomsk Cancer Research Institute; Laboratory for translational cellular and molecular biomedicine, Tomsk State University, Tomsk, Russia) - “Immune system contributes to the efficacy of cancer chemotherapy and outcome” Short talk of young investigator (17.50- 18.00): Ekaterina Lesovaya (Research Institute of Carcinogenesis, N.N. Blokhin Cancer Research Center, Moscow, Russia) - “Selective glucocorticoid receptor agonists as novel anti-cancer agents” Short talk (18.00-18.15): Professor Nickolai Barlev (Department of Chemistry, University of Leicester, Leicester, UK) - “New approaches to the rational design of anticancer drugs” Short talk (18.15-18.30): Professor Irina Guzhova, (Institute of Cytology of Russian Academy of Sciences, St. Petersburg, Russia) - “Targeting tumor cells with Hsp70 chaperone” Short talk of young investigator (18.30-18.40): Olga Shatova (Donetsk National Medical University, Ukraine) - “Metformin in breast cancer therapy” Short talk (18.40-18.55): Dr. Nikolai V. Litviakov (Tomsk Cancer Research Institute, Tomsk State University, Tomsk, Russia) - “Clonal evolution of breast tumor during neoadjuvant chemotherapy and metastasis” Discussion by participants (18.55-19.10) Closing Dinner (19.10-21.00) (on the premises of the Energetic Cultural Center, 36 Eniseyskay street), DAY 4 (12.07.2015) – Departure Poster Session Program 10.07.2015 – 34A Lenin avenue, TSU Research Library Poster session 1 1 Maria Aksenenko, Tatiana Ruksha (Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Ministry of Public Health, Russia) - Pathologic characteristics of BRAF V600E mutation in negative cutaneous melanoma 2 Nataliya Babyshkina, Sergey Vtorushin, Stanislav Patalyak, Tatyana Dronova, Elena Slonimskaya, Nadejda Cherdyntseva (Tomsk Cancer Research Institute, Tomsk, Russia, National Research Tomsk State University, Tomsk, Russia, Siberian State Medical University, Tomsk, Russia) - Prognostic significance of immunohistochemical and genetic markers in Russian breast cancer patients treated with adjuvant tamoxifen 3 Egor Batorov, Marina Tikhonova, Irina Kryuchkova, Vera Sergeevicheva, DariyaBatorova, Svetlana Sizikova, Galina Ushakova, Andrey Gilevich, Alexandr Ostanin, Elena Chernykh (Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia) - 4 5 6 7 8 9 10 11 12 Recovery of distinct T cell subsets under severe lymphopenic conditions in hemoblastosis patients Olga Berezina, Alexandra Shadrina, Elena Voropaeva, Tatiana Pospelova, Maxim Filipenko (Novosibirsk State Medical University, Research Institute of Chemical Biology and Fundamental Medicine, Research Institute of Therapy and Preventive Medicine, Novosibirsk, Russia) - The protective effect of G1958A SNP on the MTHFD1 gene in susceptibility to non-Hodgkin malignant lymphomas Evgeny Denisov, Tatiana Gerashchenko, Daria Pautova, Nadezhda Krakhmal, Marina Zavyalova, Nikolay Litviakov, Elena Slonimskaya, Nadezhda Cherdyntseva, Vladimir Perelmuter (Tomsk Cancer Research Institute; Laboratory for translational cellular and molecular biomedicine, Tomsk State University, Tomsk, Russia,Siberian Medical State University) - “Intratumor morphological heterogeneity in breast cancer and distant metastasis: expression analysis of genes involved in cell motility and pre-metastatic niche formation” Vladimir Gurtsevitch, Larissa Yakovleva, Liana Scherback, Elena Goncharova, Ksenia Smirnova, Natalia Senyuta (Federal State Budgetary Scientific Institution “N.N. Blokhin Russian Cancer Research Center”, Moscow, Russia) - Does LMP1 oncogene expression pattern reflect specific pathology or geographic origin of the EPSTEIN-BARR virus? Svetlana Semina, Mikhail Krasil`nikov (N. N. Blokhin Cancer Research Center, Moscow, Russia) - The role of intercellular interactions in the regulation of hormonal sensitivity of breast cancer cells Tatyana Prudnikova, Nikolay Litvyakov, Natalya Domanitskaya, Nadezhda Cherdyntseva, Valentina Belyavskaya (Institute of Molecular Biology and Biophysics, Novosibirsk, Russia; Tomsk Cancer Research Institute, Tomsk, Russia; State Research Center of Virology and Biotechnology (Vector), Koltsovo, Novosibirsk region, Russia) - The possible association of novel functional SNP of D-glucuronyl C5-epimerase (GLCE) gene with breast cancer in Siberia region Anna Bondar, Alexander Kurilshikov, Evgeny Morozkin, Marat Zaripov, Marsel Kabilov, Vladimir Voytsitskiy, Valentin Vlassov, Pavel Laktionov (Institute of Chemical Biology and Fundamental Medicine SB RAS, Academician E.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology, Novosibirsk Regional Cancer Center, Novosibirsk, Russia) - Targeted bisulfite sequencing of potential prostate cancer cell-free DNA markers: novel approach to reveal diagnostically significant molecules Elena Borobova, Denis Antonets, Ekaterina Starostina, Alena Reguzova, Olga Smirnova, Larisa Karpenko, Alexander Ilyichev, Sergey Bazhan (State Research Center of Virology and Biotechnology (Vector), Koltsovo, Novosibirsk region, Novosibirsk Research Institute of Circulation Pathology Academician E.N. Meshalkina, Russia) - Construction and studying expression in eukaryotic cells of allel-specific HLA-A*0201 DNA-vaccine against breast cancer Marina Zavyalova, Michail Buldakov, Nadezda Krakhmal , Nadezda Telegina, Sergei Vtorushin, Nadezda Cherdyntseva, Julia Kzhyshkowska. (Tomsk Cancer Research Institute, Tomsk, Russia, National Research Tomsk State University, Tomsk, Russia, Siberian State Medical University, Tomsk, Russia, Department of Innate Immunity and Tolerance, Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany) - CD68 expression in inflammatory cells infiltration of nonspecific invasive breast cancer Viacheslav Bychkov, Ekaterina Nikitina, Nikolai Litviakov (Tomsk Cancer Research Institute, National Research Tomsk State University, Tomsk, Russia)- Overall survival of head and neck cancer patients of Tomsk region 13 Mariya Chernyavskaya, Valeriy Chernych, Anatoliy Efremov, Vasiliy Atamanov (FSBI "The Acad. S.N. Fyodorov Eye Microsurgery Complex" of the Minpubhealth of Russia, Novosibirsk branch; Novosibirsk State Medical University, Department of Pathophysiology, Novosibirsk, Russia) - ,Inflammation, immune disorders and cell destruction at the local level in patients with choroidal melanoma 14 Natalyа Dementyeva, Rico Derks, Isabelle Kohler, Nikolay Merzlikin, Svjatoslav Shelepov, Daria Kokova, Alexey Sazonov, Oleg Mayboroda, Irina Saltikova (National Research Tomsk State University, Tomsk, Russia, Leiden University Medical Center, Center for Proteomics and Metabolomics, Netherlands; Siberian State Medical University, Tomsk, Russia; Regional public health autonomous institution "City Clinical Hospital No. 3")- Metabolic profiling of bile juice from the patients with cholangiocarcinoma-associated diseases 15 Mariya Dikovskaya, Tatyana Korolenko, Alexandr Trunov (Institute of Physiology and Fundamental Medicine, The S.N. Fyodorov Center “Eye Microsurgery” (Novosibirsk Branch), Research Center of Clinical and Experimental Medicine, Novosibirsk, Russia) Endogenous inhibitors of cysteine proteases cystatin C and cystatin SN in biological fluids of patients with intraocular melanoma as possible biomarkers and therapy targets 16 Mirjalol Djuraev, Abror Yusupbekov, Suleyman Abdujapparov, Hamid Qodirov, Shahlo Turdikulova (National Cancer Research Center, Tashkent, Uzbekistan) - Genetic testing in early diagnostics and prevention of gastric cancer 17 Olga Ephimova, I. Grigoreva, T. Romanova, Y. Ragino, T. Suvorova, N.Tov (Institution of Internal and Preventive Medicine, Novosibirsk State Medical University, Novosibirsk State University, Russia) - Biochemical markers and clinical symptoms in pancreatic cancer patients 18 Roman Fadeev, Marina Solovieva, Sergey Zakharov, Irina Fadeeva, Anatoly Senotov, Anatoly Golenkov, Vladimir Akatov (Institute of Theoretical and Experimental Biophysics (ITEB RAS), Pushchino, Pushchino State Natural Science Institute, Pushchino, Vladimirsky Moscow Regional Research Clinical Institute (MONIKI), Moscow, Russia; Saratov Medical Center of the FMBA of Russia, Balakovo, Russia) - Cell aggregation increases drug resistance of acute myelomonocytic leukemia cells 19 Polina Gervas, Vladimir Perelmuter (Tomsk Cancer Research Institute, Tomsk, Russia, Siberian State Medical University) - Intratumor heterogeneity of driver mutations in lung adenocarcinoma 20 Elena Kadukova, Svetlana Sushko (Institute of Radiobiology, National Academy of Sciences of Belarus, Gomel, Belarus) - Morphological and functional changes in the population of alveolar macrophages of mice with induced carcinogenesis in the lung 21 Evgeniya Grigorieva, Mikhail Karbyshev, Viktor Volkomorov, Elisabeth Kremmer, Alexander Huber, Irina Mitrofanova, Marina Zavyalova, Evgeniya Kaigorodova, Julia Kzhyshkowska, Nadezda Cherdyntseva (Tomsk Cancer Research Institute, Tomsk State University, Tomsk, Russia, International Biotechnology Center «Generium» LLC, Volginsky, Russia; Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Molecular Immunology, München, Germany; Siberian State Medical University, Tomsk, Russia, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany; German Red Cross Blood Service Baden-Württemberg – Hessen, Mannheim, Germany)- Novel monoclonal antibodies to C-terminal end of transmembrane prostate androgen- induced protein (TMEPAI) for evaluation of its role in gastric cancer 22 23 24 25 26 27 28 29 30 31 32 prognosis Elena Kashina, Dmitriy Oshchepkov, Aleksandr Shilov, Elena Antontseva, Dagmara Furman, Viacheslav Mordvinov (The Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk State University, Novosibirsk, Russia) - Dioxin-mediated regulation of expression IL-12 family cytokines in human macrophages as a factor of tumor promotion by TCDD Kirill Kirsanov, Ekaterina Lesovaya, Natalia Shalginskikh, Denis Naberezhnov, Vladimir Glazunov, Gennady Belitsky, Marianna Yakubovskaya (Blokhin Cancer Research Center, Moscow, Russia) - Multiple mechanisms of DNA minor groove binding ligand epigenetic effects Oleg Kokorev, Valentina Hodorenko, Victor Gunther (Tomsk State University, Tomsk, Russia) - Antitumor activity of allogeneic bone marrow cells immobilized in porouspermeable TiNi-based alloy scaffold Daria Kokova, Natalia Dementeva, Nadezhda Cherdyntseva, Alexey Gratchev, Julia Kzhyshkowska (Laboratory for translational cellular and molecular biomedicine, Tomsk State University, Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, University of Heidelberg, 3Tomsk Cancer Research Institute) - Detection adducts DNA in human blood and lung cancer tissue by a hybrid quadrupole time-offlight (Q-TOF) mass spectrometer Sergey Kovalenko, Galina Paul, Natalya Matyash, Anton Kozyakov (Institute of Molecular Biology and Biophysics, Biolink Ltd., Novosibirsk, Russia, Novosibirsk regional oncology hospital, Novosibirsk, Russia) - Two-Years long genetic screening of breast cancer patients in Novosibirsk (Russia) – first practical results Tatyana Kunts, Ksenia Karpukhina, Elena Mikhailova, Nikolay Varaksin, Alexsandr Autenshlyus (Novosibirsk State Medical University, Institute of Molecular Biology and Biophysics, CJSC «Vector-best», Koltsovo, Novosibirsk, Russia)- Cytokine production by malignant and benign breast tumors Tatyana Kunts, Nikolay Varaksin, Alexandr Autenshlyus (Institute of Molecular Biology and Biophysics, Novosibirsk, Russia)- Effect of polyclonal activators on cytokineproducing capacity of blood immunocompetent cells in adenoma and adenocarcinoma of the stomach Valeriia Kuzyk, Alexey Mittenberg (Institute of Cytology Russian Academy of Science, StPetersburg, Russia) - Analysis of proteasome-associated proteins in RPMI 8226 multiple myeloma cell line under combined therapy Olga Bryzgunova, Evgeniy Lekhnov, Tatiana Skvortsova, Evgeniy Morozkin, Ivan Zaporozhchenko, Alina Grigorieva, Marat Zaripov, Elena Ryabchikova, Valentin Vlassov, Pavel Laktionov (Institute of Chemical Biology and Fundamental Medicine SD RAS, Novosibirsk Regional Oncology Center, Novosibirsk Research Institute of Circulation Pathology of academician E.N. Meshalkin, Novosibirsk, Russia)- Use of extracellular RNA from urine for the diagnosis of prostate cancer Alla Leshchenko, Natalia Matsenko (BioLink Ltd., NRI MBB SB RAMS, Novosibirsk, Russia)- The development of the test system for assessment of estrogen receptor status, progesterone receptor, HER2/neu and the proliferative factor Ki67 in breast cancer by real time PCR Andrei Makashov, Andrei Kozlov (The Biomedical Center, Peter the Great St.Petersburg Polytechnic University, St.Petersburg, Russia) - The human oncogenome evolution advances ahead of the evolution of human protein-coding genome and other specific gene classes 33 Ekaterina Matiunina, Andrei Kozlov, Alexander Emelyanov (The Biomedical Center, Saint-Petersburg, Russia, Peter the Great St.Petersburg Polytechnic University, Institute for Research on Cancer and Aging, Nice)- Evolutionary novel genes expressed in fish tumors determine progressive evolutionary characters 11.07.2015 – 34A Lenin avenue, TSU Research Library Poster session 2 34 Margarita Kruchinina, Andrey Starikov, Svetlana Kurilovich, Vladimir Kruchinin, Vladimir Volodin, Sergey Rykhlitskii, Andrey Gromov, Sergey Peltec, Sergey Shehovtsov, Vladimir Generalov (Institution of Internal and Preventive Medicine, Regional Oncology Center, Rzhanov’s Institute of Semiconductor Physics Siberian Branch of Russian Academy of Sciences, Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia; The State Research Center of Virology and Biotechnology VECTOR, Novosibirsk region, Russia) - Role of the optical methods for blood study in staging of colorectal cancer 35 Darya Meshalkina, Maxim Shevtsov, Boris Margulis, Irina Guzhova (Institute of Cytology, RAS, Saint-Petersburg, Russia) - Molecular chaperones Hdj1, Hdj2 and Hsp70 in model glioma metastasis progression 36 Sandra Hofmann, Irina Bure, Abbas Agaimy, Arndt Hartmann, Florian Haller, Evgeny A. Moskalev (Institute of Pathology, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany) -Long non-coding RNA HOTAIR affects DNA methylation patterns in gastrointestinal stromal tumours (GIST) 37 Tatiana Nikitenko, Oksana Rymar, Sofia Malyutina, Lilia Shcherbakova, Eugene Verevkin, Svetlana Kurilovich (Federal State Budgetary of Scientific Institution «Institution of Internal and Preventive Medicine», Novosibirsk, Russia) - Components of the metabolic syndrome in patients with colorectal cancer: case-control study 38 Ekaterina Nikitina, Olga Cheremisina, Denis Kulbakin, Nikolay Litviakov (Tomsk Cancer Research Institute, Tomsk State University, Tomsk, Russia) - MicroRNA-21, -155, -200c and -205 in carcinogenesis of larynx 39 Nadezhda Palkina, Tatiana Ruksha (Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Ministry of Public Health, Russia) - Matrix metalloproteinase -9 and -13 as regulators of TGF-β-the signal transduction pathway in melanoma tumor cells 40 Alexey Petukhov, Alexandra Daks, Oleg Shuvalov, Nikolaj Barlev (Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia) - Detection of COP1-interacting proteins using co-immunoprecipitation followed MALDI-TOF mass spectrometry 41 Ekaterina Pisareva, Nadezhda Gutkina, Sergey Kovalenko, Vladimir Shamanin (Institute of molecular biology and biophysics, BioLink Ltd., Novosibirsk, Russia) - Development of allele-specific PCR assays for detection of mutations in KRAS gene in colorectal cancer in Russian patients 42 Anastasia Ponomaryova, Elena Rykova, Nadezhda Cherdyntseva, Evgeny Morozkin, Ivan Zaporozhchenko, Tatiana Skvortsova, Аlexey Dobrodeev, Alexander Zav’yalov, Sergey Tuzikov, Valentin Vlassov, Pavel Laktionov (Tomsk Cancer Research Institute, Tomsk, Russia, Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia, National Research Tomsk Polytechnic University, Tomsk, Russia, National Research 43 44 45 46 47 48 49 50 51 52 Tomsk State University, Tomsk, Russia) - Dynamic changes of circulating microRNA expression in response to the lung cancer combined therapy Dominika Pszczółkowska, Aleksandra Ellert-Miklaszewska, Anna Gieryng, Magdalena Kijewska, Pawel Wiśniewski, Bożena Kamińska (Nencki Institute of Experimental Biology Polish Academy of Sciences, Warszawa, Poland) - Glioma-derived osteopontin and lactadherin shape tumormicroenvironment and immune response in rat model of glioma Ekaterina Rybalkina, Galina Pavlova, Natalia Moiseeva, Olga Susova, Aleksei Mitrofanov, Dmitrii Panteleev, Nikolai Pustogarov (FSBI "N.N.Blokhin Russian Cancer Research Center", Institute of Gene Biology of Russian Academy of Sciences, Moscow, Russia) Participation of the genes MVP/LRP and YB-1 in the determination of the rate of sensitivity of glioblastoma cells to temodal Yelena Shapovalova, Daria Lytkina, Liudmila Rasskazova, Anatoly Filimoshkin, Irina Kurzina, Julia Kzhyshkowska (National Research Tomsk State University, Laboratory of translational cellular and molecular biomedicine, Tomsk State University, Tomsk, Russia) Bioresorbable composites based on hydroxyapatite dispersed in Poly-L-lactide matrix Elena Shashova, Elena Kolegova, Yulia Lyupina, Elena Slonimskaya, Irina Kondakova, Nataliya Sharova (Tomsk Cancer Research Institute, Tomsk, Russia, Siberian State Medical University, Tomsk, Russia, NK Koltsov Institute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia) - Features of proteasome system functioning in the tumor and microenvironment cells of breast cancer Sergei Shevchenko, Lyudmila Mostovich, Galina Logacheva, Svetlana Svyatchenko, Lyudmila Gulyaeva (Novosibirsk State University, Institute of Molecular Biology and Biophysics, SB RAS, Novosibirsk Municipal Clinical Hospital No.1, Novosibirsk, Russia) Integrin receptors and their ligands as potential biomarkers in preoperative diagnosis of papillary thyroid carcinoma Sergei Shevchenko, Lyudmila Mostovich, Nikolai Kolesnikov, Lyudmila Gulyaeva (Institute of Molecular Biology and Biophysics SB RAMS, Novosibirsk Municipal clinical Hospital № 1, Novosibirsk State University, Institute of Molecular and Cell Biology SB RAS, Novosibirsk, Russia) - Molecular biomarkers in preoperative diagnosis of thyroid cancer Anna Silyutina, Sergei Zhuk, Pavel Butylin, Andrey Zaritskey (Institute of Hematology, Federal North-West Medical Research Centre, Saint-Petersburg, Russia) - Macrophages with JAK2V617F mutation are activated by platelets: role in pathogenesis of myelofibrosis Sergey Solodskikh, Viktor Bashmakov, Tatiana Gorbacheva, Anna Panevina, Alexander Maslov, Andrei Mikhailov, Ivan Moshuro, Vasily Popov (Voronezh State University, Voronezh Regional Clinical Oncology Center, Voronezh, Russia, Albert Einstein College of Medicine of Yeshiva University, NY, USA) - Integrated analysis of genomic and transcriptomic data in clear-cell renal cell carcinoma Natalia Tarasenko, Liudmila Spirina, Evgeny Usynin, Alexei Gorbunov (The Research Institute for Medical Genetics, Tomsk, Russia, Tomsk Cancer Research Institute, Tomsk, Russia, Siberian State Medical University, Tomsk, Russia)- Genetic aspects of prostate cancer development Marina Stakheyeva, Alexandr Anufrak, Nadezhda Cherdyntseva, Julia Kzhyshkowska, Vladimir Faltin, Sergey Avdeev (Tomsk Cancer Research Institute, Tomsk, Russia, Tomsk State University, Tomsk, Russia, Department of Innate Immunity and Tolerance, Institute of 53 54 55 56 57 58 59 60 61 Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Germany) - The subsets of peripheral blood monocytes in cancer patients Ekaterina Starostina, Denis Antonets, Elena Borobova, Larisa Karpenko, Alena Reguzova, Olga Smirnova, Alexander Ilyichev, Sergei Bazhan (State Research Center of Virology and Biotechnology “Vector”, Koltsovo, Novosibirsk region, Russia) - DNA-vaccines against melanoma: design and investigation of antigenic properties Svetlana Tamkovich, Oleg Tutanov, Alina Grigor’eva, Tatiana Duzhak, Natalia Kirushina, Valentina Permyakova, Elena Ryabchikova, Vladimir Voicitsckyi, Valentin Vlassov, Pavel Laktionov (Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia, Novosibirsk State University, Novosibirsk, Russia, Institute of Tomografic Center SB RAS, National Novosibirsk Regional Oncologic Dispensary, Novosibirsk, Russia, Central Clinical Hospital, Novosibirsk, Russia) - Blood cell-surface-bound exosomes as a new source of tumor-specific microRNA Svetlana Tamkovich, Anna Bondar, Igor Morozov, Natalia Kirushina, Valentina Permyakova, Vladimir Voitsitskiy, Pavel Laktionov (Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia, Novosibirsk State University, Novosibirsk, Russia, National Novosibirsk Regional Oncologic Dispensary, Novosibirsk, Russia, Central Clinical Hospital, Novosibirsk, Russia)- The characterization of total circulating DNA from blood of healthy donors and cancer patients Leyla Tilova, Olga Zadorozhnaya, Alena Savinkova, Kirill Kirsanov, Anna Ogloblina, Gennadiy Belitsky, Irina Budunova, Ekaterina Lesovaya, Marianna Yakubovskaya (Blokhin Cancer Research Center, Department of Chemical Carcinogenesis, Moscow, Russia, Northwestern University, Feinberg Medical School, Department of Dermatology, Chicago, USA) - Synthesis and anti-cancer effects of CpdA enantiomers, non-steroidal glucocorticoid receptor ligands Alexandra Tsidulko, Liudmila Matskova, Lidiia Astakhova, Ingemar Ernberg, Elvira Grigorieva (MTC, Karolinska Institute, Stockholm, Sweden, The Institute of Molecular Biology and Biophysics, Novosibirsk, Russia, Kemerovo Institute of Food Science and Technology, Kemerovo, Russia) - Proteoglycans expression correlates with the phenotype of malignant and non-malignant EBV-positive B-cell lines Matvei Tsyganov, Marina Ibragimova, Nikolay Litviakov, Nadezhda Cherdyntseva (Tomsk Cancer Research Institute, Tomsk, Russia, National Tomsk State University, Tomsk, Russia) Microarray research of allelic imbalance in breast cancers during neoadjuvant chemotherapy Tamara Tyrinova, Alexander Ostanin, Sergey Mishinov, Lyudmila Sakhno, Sergey Chernov, Vyacheslav Stupak, Elena Chernykh (Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia, Institute of Traumatology and Orthopedics, Novosibirsk, Russia, Federal Neurosurgical Center, Novosibirsk, Russia)- Multiplex analysis of 27 cytokines produced by low-grade and high-grade glioma cells Tamara Tyrinova, Olga Leplina, Marina Tikhonova, Sergey Mishinov, Sergey Chernov, Lyudmila Sakhno, Vyacheslav Stupak, Elena Chernykh (Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia, Institute of Traumatology and Orthopedics, Novosibirsk, Russia, Federal Neurosurgical Center, Novosibirsk, Russia)- Glioma-derived soluble factors pose strong chemoattractants and parrtially change the cytotoxic activity of IFN-alpha-induced dendritic cells Ivan A Zaporozhchenko, Evgeny S Morozkin, Tatyana E Skvortsova, Elena Yu Rykova, Anastasiya A Ponomareva, Nadezhda V Cherdyntseva, Evgeny S Polovnikov, Olga Yu Anikeeva, Oksana A Pashkovskaya, Valentin V Vlassov, Pavel P Laktionov (Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia, Novosibirsk Research Institute of Circulation Pathology of E.N. Meshalkin, Novosibirsk, Russia, Tomsk Cancer Research Institute, Tomsk, Russia) - Plasma microRNAs as noninvasive biomarkers for diagnostics of lung cancer Sponsors