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Tomsk Cancer Research Institute
Tomsk State University
University of Heidelberg, Germany
Technology Platform “Medicine of the Future”
By support
Russian Foundation for Basic Research (RFBR)
The European Molecular Biology Organization (EMBO)
EMBO WORKSHOP
«CELLULAR AND MOLECULAR
MECHANISM OF TUMOUR MICROENVIRONMENT CROSSTALK»
9 – 12 JULY 2015 | TOMSK, RUSSIA
Scientific Program
GENERAL INFORMATION
This Workshop is being held at the National Research Tomsk State University (TSU), located in the
heart of the Tomsk.
Workshop locations address
DAY 1 – 09.07.2015 – 34A Lenin avenue, TSU Research Library- 7 and 36 Lenin avenue, TSU Main
Building –(1 (social events)
DAY 2-3 – 10.07.-11.07.2015 – 34A Lenin avenue, TSU Research Library-
7
Scientific Committee
Julia Kzhyshkowska, Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim,
Heidelberg University; Heidelberg, Germany
Evgeny L. Choynzonov, Tomsk Cancer Research Institute, Tomsk, Russia
Eduard V. Galazhinsky, National Research Tomsk State University, Tomsk, Russia
Feodor L. Kisseljov, Research Institute of Carcinogenesis, N.N. Blokhin Cancer Research Center,
Moscow, Russia
Evgeny N. Imyanitov, N.N. Petrov Institute of Oncology, Sent-Petersburg, Russia
Valery P. Puzyrev, Research Institute of Medical Genetics, Tomsk, Russia
Mikhail I. Voevoda, Research Institute of Therapy and Preventive Medicine, Novosibirsk, Russia
Nadezda V. Cherdyntseva, Tomsk Cancer Research Institute, Tomsk, Russia; National Research
Tomsk State University, Tomsk, Russia
Mikhail A. Krasilnikov, N.N. Blokhin Cancer Research Center, Moscow, Russia
Marianna G. Yakubovskaya, Research Institute of Carcinogenesis, N.N. Blokhin Cancer Research
Center, Moscow, Russia
Contact information
Tomsk Cancer Research Institute
5 Kooperativny Street
634050, Tomsk, Russia
www.oncology.tomsk.ru
National Research Tomsk State University
36 Lenin Avenue
634050, Tomsk, Russia
www.tsu.ru
DAY 1 - 09.07.2015
34A Lenin avenue, TSU Research Library
Registration
15.00-16.30
Welcome Remarks and Opening Ceremony
16.30-17.00
17.00-17.30
Coffee break
17.30-18.30
Keynote Lecture
19.00-21.30
Welcome reception ( 36 Lenin TSU main building)
DAY 2 - 10.07.2015
34A Lenin avenue, TSU Research Library
Section 1
09.00-10.30
Invited Lectures
10.30-10.50
Coffee break
10.50-12.15
Invited Lectures
12.15-13.00
Short talk/ Short talk of young investigator
13.00-13.10
Discussion
13.10-14.00
14.00-15.00
Lunch
Poster Session 1
Section 2
15.00-15.45
Invited Lecture
15.45-16.20
Short talk/ Short talk of young investigator
16.20-16.50
Coffee break
16.50-18.50
Short talk/ Short talk company
18.50-19.10
Discussion
19.10-21.30
DAY 3 - 11.07.2015
Evening city tour
34A Lenin avenue, TSU Research Library
Section 3
9.00-9.45
Invited Lecture
9.45-10.50
Short talk/ Short talk of young investigator
10.50-11.10
Coffee break
11.10-12.20
Short talk/ Short talk of young investigator
12.20-12.30
Discussion
12.30-13.30
13.30-14.30
Lunch
Poster Session 2
Section 4
14.30-16.00
Invited Lecture
16.00-16.30
Coffee break
16.30-18.55
Short talk/ Short talk of young investigator
Discussion
Closing Dinner
19.10-22.00
(on the premises of the Celebration Hall, 36 Eniseyskay street)
DAY 4 - 12.07.2015
Departure
18.55-19.10
DAY 1 (09.07.2015) – 34A Lenin avenue, TSU Research Library
Registration (15.00-16.30)
Welcome Remarks (16.30-16.45)
Chairmen: Professor Eduard V. Galazhinsky
Governor of Tomsk region, Sergey Zhvachkin; Rector of Tomsk State University, Professor Eduard
V. Galazhinsky; Director of Tomsk Cancer Research Institute, Academician of RAN, Professor
Evgeny L. Choynzonov
Opening Ceremony (16.45-17.00)
Moderated by Professor. Dr. Julia Kzhyshkowska
Governor of Tomsk region, Sergey Zhvachkin; Rector of Tomsk State University, Professor Eduard
V. Galazhinsky; Director of Tomsk Cancer Research Institute, Academician of RAN, Professor
Evgeny L. Choynzonov
Coffee break (17.00-17.30)
Oral Session Program
Chairmen: Prof. Dr. Julia Kzhyshkowska
Keynote Lecture (17.30-18.30): Professor Harald zur Hausen (Germany Cancer Research Centre,
Heidelberg, Germany) - “The Search for Viruses in Human Cancer and Chronic Diseases”
Welcome reception (open to all registered persons, 19.00-21.30) 36 Lenin avenue, TSU Main Building
DAY 2 (10.07.2015) – 34A Lenin avenue, TSU Research Library
Section 1. Immune system and inflammation: role in tumor development. Tumor
microenvironment (9.00-13.00)
Chairmen: Prof. Mikhail A. Krasilnikov, Prof. Dr. Julia Kzhyshkowska, Prof. Peter Chumakov
Invited Lecture (9.00-9.45): Professor Ron N. Apte (Faculty of Health Sciences and The Cancer
Research Center, Ben-Gurion University of the Negev Beer-Sheva, Israel) - “Cytokine regulation of
tumor microenvironment”
Invited Lecture (9.45-10.30): Professor Siamon Gordon (University of Oxford, UK) - “Macrophage
heterogeneity in its normal and pathological microenvironment”
Coffee break (10.30-10.50)
Chairmen: Prof. Günter Hammerling, Prof. Nadezhda Cherdyntseva, Prof. Fiodor Kisselev
Invited Lecture (10.50-11.35): Professor Ethel-Michelle de Villiers (Germany Cancer Research Centre,
Heidelberg, Germany) - “Diversity of circular single-stranded DNA viruses and their relationship to human
disease”
Invited Lecture (11.35-12.20): Professor Michael Kirschfink (University of Heidelberg, Germany) “Complement system in anti-tumor response: mechanisms and therapeutic strategies”
Short talk (12.20-12.35): Professor Mikhail A. Krasilnikov (N.N. Blokhin Cancer Research Center,
Moscow, Russia) - “The role of cell-cell interactions in the maintaining of autonomous growth and
formation of the resistant phenotype of tumor cells”
Short talk of young investigator (12.35-12.45): Dmitry Zinovkin (Gomel State Medical University,
Gomel, Belarus) - “The immune and vascular components of microenvironment in prognosis of the
endometrioid endometrial adenocarcinoma”
Short talk of young investigator (12.45-12.55): Anastasia Suhovskih (Institute of Molecular Biology
and Biophysics, Novosibirsk, Russia) - “An important role of proteoglycans in the interactions of
normal and cancer prostate cells with fibroblasts”
Short talk (12.55-13.05): Olga Bajenova (Dobzhansky Center for Genome Bioinformatics, St.
Petersburg State University, Russia) - “Effect of carcinoembryonic antigen production by colorectal
cancer cells on tumor microenvironment and cancer progression”
Discussion by participants (13.05-13.10)
Lunch (13.10 – 14.00)
Poster Session 1 (14.00-15.00)
Section 2. Bacterial and viral pathogen contribution to tumor microenvironment (15.00-19.00)
Chairmen: Prof. Siamon Gordon, Dr. Alexei Gratchev, Dr. Anna Zajakina
Invited Lecture (15.00-15.45): Professor Peter Chumakov (Engelhardt Institute of Molecular Biology,
Moscow, Russia) - “Targeting cancer by viruses”
Short talk (15.45-16.10): Professor Evgeny N. Imyanitov (N.N. Petrov Institute of Oncology, St.
Petersburg, Russia) – “Hereditary cancer syndromes in Russia”
Short talk company (16.10-16-20): Marina Wiklander (Sigma Aldrich) - Next Generation Gene
Editing and Gene Silencing Technologies
Coffee break (16.20-16.50)
Short talk (16.50-17.15): Professor Feodor L. Kisseljov (Research Institute of Carcinogenesis, N.N.
Blokhin Cancer Research Center, Moscow, Russia) -“Epigenetic changes in human cervical
carcinoma associated with viral-induced pathogenesis”
Short talk (17.15-17.35): Dr. Tatyana Isayeva (University of Alabama at Birmingham.) - “Human
papilloma virus association with survival of head and neck cancer patients”
Short talk (17.35-17.55): Dr. Anna Zajakina (Latvian Biomedical Research and Study Centre, Riga,
Latvia) - “Advances in Alpha virus-based anti-cancer therapy”
Short talk 17.55-18.10): Dr. Pavel P. Laktionov (Institute of Chemical Biology and Fundamental
Medicine, Novosibirsk, Russia) - “Non-invasive, circulating nucleic acids-based tumor diagnostics:
looking for epigenetic markers”
Short talk company (18.10-18.20): Dr. Bjoern Biedermann (Life Technologies, USA) - “Advantages
of acoustic focusing in flow cytometry and state of the art microscopy on your bench”
Short talk company (18.20-18.30): Dr. Pavel Natalin (Thermo Fisher Scientific Inc, USA) “LiquidBiopsy ™Platform: highly multiplexed molecular analysis of CTCs, cfDNA, and germline
DNA”
Short talk company (18.30-18.40): Marina Prokhorova (Merck Millipore, USA) - “Cancer RNA
detection in live cells with SmartFlare™ RNA detection probes”
Short talk company (18.40-18.50): Dmitry Kvon (Agilent Technologies, USA) - “Agilent target
enrichment technology for next-generation sequencing. New application for oncology”
Short talk company (18.50-19.00): Anna Voitovich (ОPТEК) – “WAVE System – Mutation
screening by DHPLC in gene diagnostic of oncological diseases”
Discussion by participants (19.00-19.10)
Evening city tour (19.15-21.15)
DAY 3 (11.07.2015) – 34A Lenin avenue, TSU Research Library
Section 3. Immune system and inflammation in tumor invasion and metastasis. Metastatic nishes
(9.00-12.30)
Chairmen: Professor Vessela Kristensen, Professor Evgeny N. Imyanitov, Dr. Marianna G.
Yakubovskaya
Invited Lecture (9.00-9.45): Professor Julia Kzhyshkowska (Institute of Transfusion Medicine and
Immunology, Medical Faculty Mannheim, Heidelberg University; Heidelberg, Germany) “Macrophage plasticity and perspectives for their reprogramming in tumor microenvironment”
Short talk (9.45-10.00): Professor Ospan A Mynbaev (Moscow Institute of Physics and Technology,
Dolgoprudny, Russia; Ghent University, Ghent, Belgium) - “An oxidative stress during laparoscopic
surgery is a possible triggering factor of cancer cell metastasis”
Short talk (10.00-10.20): Dr. Vladimir Ryabov (University of Heidelberg, Medical Faculty Mannheim,
Heidelberg, Germany) - “Role of M2 marker stabillin-1 in tumor progression”
Short talk of young investigator (10.20-10.30): Zahid Pranjol (Institute of Biomedical and Clinical
Scince, University of Exeter Medical School, UK) - “Tumour secreted factors cathepsins D and L
induce pro-angiogenic changes in human omental microvascular endothelial cells (HOMECs) in
ovarian cancer metastasis”
Short talk of young investigator (10.30-10.40): Amulang Shikeeva (Research Centre for Medical
Genetics, Moscow) - “Allelic imbalance and epigenetic changes as a marker of tumor spreading
into the adjacent tissue”
Short talk of young investigator (10.40-10.50): Geok Choo Sim (UT MD Anderson Cancer Center,
USA) - “Comprehensive flow cytometry tracking of regulatory T cells and other lymphocyte
subsets during HD IL-2 therapy for melanoma”
Coffee break (10.50-11.10)
Short talk (11.10-11.30): Dr. Antonina Y. Alexandrova (N.N. Blokhin Cancer Research Center,
Moscow, Russia) - “The plasticity of tumor cell migration mechanisms as the adaptive factor,
increasing metastasis efficiency”
Short talk of young investigator (11.30-11.45): Evgeny Denisov (Tomsk Cancer Research Institute;
Laboratory for translational cellular and molecular biomedicine, Tomsk State University, Tomsk,
Russia) – “Intratumor morphological heterogeneity of breast cancer as a reflection of cancer
invasion patterns: clinical significance and genetic portrait“
Short talk of young investigator (11.45-12.00): Dr. Evgeniya V. Kaigorodova (Department of
Pathological Anatomy and Cytology, Cancer Research Institute; Laboratory for translational cellular
and molecular biomedicine, Tomsk State University, Tomsk, Russia) - “Circulating tumor cells and
bone marrow progenitor cells in the blood of breast cancer patients in the dynamics of
neoadjuvant chemotherapy”
Short talk (12.00-12.15): Professor Tatiana Ruksha (Krasnoyarsk State Medical University,
Krasnoyarsk, Russia) - “MicroRNA signature differs in melanoma microenvironment and tumor
cells”
Short talk of young investigator (12.15-12.25): Grigory Raskin (Russian Scientific Center of
Radiological and Surgical Technologies, St. Petersburg, Russia) - “Morphologic evaluation of
prognostic factors in colon adenocarcinoma”
Discussion by participants (12.25-12.30)
Lunch (12.30 – 13.30)
Poster Session 2 (13.30-14.30)
Section 4. Molecular markers and targets for cancer therapy. Microenvironment reprogramming
as the innovative approach to cancer therapy (14.30-19.00)
Chairmen: Professor Michael Kirschfink, Dr. Antonina Y. Alexandrova
Invited Lecture (14.30-15.15): Professor Vessela Kristensen (Institute for Cancer Research, University
Hospital, Oslo, Norway) - “Integrated genomic analyses of breast cancer, relevance for better
prognosis and treatment evaluation”
Invited Lecture (15.15-16.00): Professor Günter Hammerling (German Cancer Research Centre
(DKFZ), Heidelberg, Germany) - “Strategic manipulation of the microenvironment for efficient
immunological cancer therapy”
Coffee break (16.00-16.30)
Short talk (16.30-16.50): Dr. Maxim Freidin (National Heart and Lung Institute, Imperial College
London, UK) - “Blood-based biomarkers for lung cancer”
Short talk (16.50-17.10): Dr. Marianna G. Yakubovskaya (Research Institute of Carcinogenesis, N.N.
Blokhin Cancer Research Center, Moscow, Russia) - “Epigenetic xenobiotics as factors, increasing
efficiency of antitumor drugs”
Short talk (17.10-17.30): Dr. Alexei Gratchev (Research Institute of Carcinogenesis, N.N. Blokhin
Cancer Research Center, Moscow, Russia; University of Heidelberg, Germany) - “Development of
innovative technologies for anti-cancer drug delivery”
Short talk (17.30-17.50): Professor Nadezda V. Cherdyntseva (Laboratory of Molecular Oncology and
Immunology, Tomsk Cancer Research Institute; Laboratory for translational cellular and molecular
biomedicine, Tomsk State University, Tomsk, Russia) - “Immune system contributes to the efficacy
of cancer chemotherapy and outcome”
Short talk of young investigator (17.50- 18.00): Ekaterina Lesovaya (Research Institute of
Carcinogenesis, N.N. Blokhin Cancer Research Center, Moscow, Russia) - “Selective glucocorticoid
receptor agonists as novel anti-cancer agents”
Short talk (18.00-18.15): Professor Nickolai Barlev (Department of Chemistry, University of Leicester,
Leicester, UK) - “New approaches to the rational design of anticancer drugs”
Short talk (18.15-18.30): Professor Irina Guzhova, (Institute of Cytology of Russian Academy of
Sciences, St. Petersburg, Russia) - “Targeting tumor cells with Hsp70 chaperone”
Short talk of young investigator (18.30-18.40): Olga Shatova (Donetsk National Medical University,
Ukraine) - “Metformin in breast cancer therapy”
Short talk (18.40-18.55): Dr. Nikolai V. Litviakov (Tomsk Cancer Research Institute, Tomsk State
University, Tomsk, Russia) - “Clonal evolution of breast tumor during neoadjuvant chemotherapy
and metastasis”
Discussion by participants (18.55-19.10)
Closing Dinner (19.10-21.00) (on the premises of the Energetic Cultural Center, 36 Eniseyskay street),
DAY 4 (12.07.2015) – Departure
Poster Session Program
10.07.2015 – 34A Lenin avenue, TSU Research Library
Poster session 1
1 Maria Aksenenko, Tatiana Ruksha (Krasnoyarsk State Medical University named after
Prof. V.F. Voino-Yasenetsky, Ministry of Public Health, Russia) - Pathologic characteristics
of BRAF V600E mutation in negative cutaneous melanoma
2 Nataliya Babyshkina, Sergey Vtorushin, Stanislav Patalyak, Tatyana Dronova, Elena
Slonimskaya, Nadejda Cherdyntseva (Tomsk Cancer Research Institute, Tomsk, Russia,
National Research Tomsk State University, Tomsk, Russia, Siberian State Medical
University, Tomsk, Russia) - Prognostic significance of immunohistochemical and genetic
markers in Russian breast cancer patients treated with adjuvant tamoxifen
3 Egor Batorov, Marina Tikhonova, Irina Kryuchkova, Vera Sergeevicheva, DariyaBatorova,
Svetlana Sizikova, Galina Ushakova, Andrey Gilevich, Alexandr Ostanin, Elena Chernykh
(Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia) -
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Recovery of distinct T cell subsets under severe lymphopenic conditions in
hemoblastosis patients
Olga Berezina, Alexandra Shadrina, Elena Voropaeva, Tatiana Pospelova, Maxim Filipenko
(Novosibirsk State Medical University, Research Institute of Chemical Biology and
Fundamental Medicine, Research Institute of Therapy and Preventive Medicine, Novosibirsk,
Russia) - The protective effect of G1958A SNP on the MTHFD1 gene in susceptibility to
non-Hodgkin malignant lymphomas
Evgeny Denisov, Tatiana Gerashchenko, Daria Pautova, Nadezhda Krakhmal, Marina
Zavyalova, Nikolay Litviakov, Elena Slonimskaya, Nadezhda Cherdyntseva, Vladimir
Perelmuter (Tomsk Cancer Research Institute; Laboratory for translational cellular and
molecular biomedicine, Tomsk State University, Tomsk, Russia,Siberian Medical State
University) - “Intratumor morphological heterogeneity in breast cancer and distant
metastasis: expression analysis of genes involved in cell motility and pre-metastatic
niche formation”
Vladimir Gurtsevitch, Larissa Yakovleva, Liana Scherback, Elena Goncharova, Ksenia
Smirnova, Natalia Senyuta (Federal State Budgetary Scientific Institution “N.N. Blokhin
Russian Cancer Research Center”, Moscow, Russia) - Does LMP1 oncogene expression
pattern reflect specific pathology or geographic origin of the EPSTEIN-BARR virus?
Svetlana Semina, Mikhail Krasil`nikov (N. N. Blokhin Cancer Research Center, Moscow,
Russia) - The role of intercellular interactions in the regulation of hormonal sensitivity
of breast cancer cells
Tatyana Prudnikova, Nikolay Litvyakov, Natalya Domanitskaya, Nadezhda Cherdyntseva,
Valentina Belyavskaya (Institute of Molecular Biology and Biophysics, Novosibirsk,
Russia; Tomsk Cancer Research Institute, Tomsk, Russia; State Research Center of Virology
and Biotechnology (Vector), Koltsovo, Novosibirsk region, Russia) - The possible
association of novel functional SNP of D-glucuronyl C5-epimerase (GLCE) gene with
breast cancer in Siberia region
Anna Bondar, Alexander Kurilshikov, Evgeny Morozkin, Marat Zaripov, Marsel Kabilov,
Vladimir Voytsitskiy, Valentin Vlassov, Pavel Laktionov (Institute of Chemical Biology and
Fundamental Medicine SB RAS, Academician E.N. Meshalkin Novosibirsk State Research
Institute of Circulation Pathology, Novosibirsk Regional Cancer Center, Novosibirsk,
Russia) - Targeted bisulfite sequencing of potential prostate cancer cell-free DNA
markers: novel approach to reveal diagnostically significant molecules
Elena Borobova, Denis Antonets, Ekaterina Starostina, Alena Reguzova, Olga Smirnova,
Larisa Karpenko, Alexander Ilyichev, Sergey Bazhan (State Research Center of Virology and
Biotechnology (Vector), Koltsovo, Novosibirsk region, Novosibirsk Research Institute of
Circulation Pathology Academician E.N. Meshalkina, Russia) - Construction and studying
expression in eukaryotic cells of allel-specific HLA-A*0201 DNA-vaccine against breast
cancer
Marina Zavyalova, Michail Buldakov, Nadezda Krakhmal , Nadezda Telegina, Sergei
Vtorushin, Nadezda Cherdyntseva, Julia Kzhyshkowska. (Tomsk Cancer Research Institute,
Tomsk, Russia, National Research Tomsk State University, Tomsk, Russia, Siberian State
Medical University, Tomsk, Russia, Department of Innate Immunity and Tolerance, Institute
of Transfusion Medicine and Immunology, Medical Faculty Mannheim, University of
Heidelberg, Mannheim, Germany) - CD68 expression in inflammatory cells infiltration of
nonspecific invasive breast cancer
Viacheslav Bychkov, Ekaterina Nikitina, Nikolai Litviakov (Tomsk Cancer Research
Institute, National Research Tomsk State University, Tomsk, Russia)- Overall survival of
head and neck cancer patients of Tomsk region
13 Mariya Chernyavskaya, Valeriy Chernych, Anatoliy Efremov, Vasiliy Atamanov (FSBI
"The Acad. S.N. Fyodorov Eye Microsurgery Complex" of the Minpubhealth of Russia,
Novosibirsk branch; Novosibirsk State Medical University, Department of Pathophysiology,
Novosibirsk, Russia) - ,Inflammation, immune disorders and cell destruction at the local
level in patients with choroidal melanoma
14 Natalyа Dementyeva, Rico Derks, Isabelle Kohler, Nikolay Merzlikin, Svjatoslav Shelepov, Daria
Kokova, Alexey Sazonov, Oleg Mayboroda, Irina Saltikova (National Research Tomsk State
University, Tomsk, Russia, Leiden University Medical Center, Center for Proteomics and
Metabolomics, Netherlands; Siberian State Medical University, Tomsk, Russia; Regional public
health autonomous institution "City Clinical Hospital No. 3")- Metabolic profiling of bile juice
from the patients with cholangiocarcinoma-associated diseases
15 Mariya Dikovskaya, Tatyana Korolenko, Alexandr Trunov (Institute of Physiology and
Fundamental Medicine, The S.N. Fyodorov Center “Eye Microsurgery” (Novosibirsk
Branch), Research Center of Clinical and Experimental Medicine, Novosibirsk, Russia) Endogenous inhibitors of cysteine proteases cystatin C and cystatin SN in biological
fluids of patients with intraocular melanoma as possible biomarkers and therapy
targets
16 Mirjalol Djuraev, Abror Yusupbekov, Suleyman Abdujapparov, Hamid Qodirov, Shahlo
Turdikulova (National Cancer Research Center, Tashkent, Uzbekistan) - Genetic testing in
early diagnostics and prevention of gastric cancer
17 Olga Ephimova, I. Grigoreva, T. Romanova, Y. Ragino, T. Suvorova, N.Tov (Institution of
Internal and Preventive Medicine, Novosibirsk State Medical University, Novosibirsk State
University, Russia) - Biochemical markers and clinical symptoms in pancreatic cancer
patients
18 Roman Fadeev, Marina Solovieva, Sergey Zakharov, Irina Fadeeva, Anatoly Senotov,
Anatoly Golenkov, Vladimir Akatov (Institute of Theoretical and Experimental Biophysics
(ITEB RAS), Pushchino, Pushchino State Natural Science Institute, Pushchino, Vladimirsky
Moscow Regional Research Clinical Institute (MONIKI), Moscow, Russia; Saratov Medical
Center of the FMBA of Russia, Balakovo, Russia) - Cell aggregation increases drug
resistance of acute myelomonocytic leukemia cells
19 Polina Gervas, Vladimir Perelmuter (Tomsk Cancer Research Institute, Tomsk, Russia,
Siberian State Medical University) - Intratumor heterogeneity of driver mutations in lung
adenocarcinoma
20 Elena Kadukova, Svetlana Sushko (Institute of Radiobiology, National Academy of Sciences
of Belarus, Gomel, Belarus) - Morphological and functional changes in the population of
alveolar macrophages of mice with induced carcinogenesis in the lung
21 Evgeniya Grigorieva, Mikhail Karbyshev, Viktor Volkomorov, Elisabeth Kremmer,
Alexander Huber, Irina Mitrofanova, Marina Zavyalova, Evgeniya Kaigorodova, Julia
Kzhyshkowska, Nadezda Cherdyntseva (Tomsk Cancer Research Institute, Tomsk State
University, Tomsk, Russia, International Biotechnology Center «Generium» LLC, Volginsky,
Russia; Helmholtz Zentrum München, German Research Center for Environmental Health,
Institute of Molecular Immunology, München, Germany; Siberian State Medical University,
Tomsk, Russia, University Medical Centre Mannheim, University of Heidelberg, Mannheim,
Germany; German Red Cross Blood Service Baden-Württemberg – Hessen, Mannheim,
Germany)- Novel monoclonal antibodies to C-terminal end of transmembrane prostate
androgen- induced protein (TMEPAI) for evaluation of its role in gastric cancer
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prognosis
Elena Kashina, Dmitriy Oshchepkov, Aleksandr Shilov, Elena Antontseva, Dagmara
Furman, Viacheslav Mordvinov (The Institute of Cytology and Genetics of the Siberian
Branch of the Russian Academy of Sciences, Novosibirsk State University, Novosibirsk,
Russia) - Dioxin-mediated regulation of expression IL-12 family cytokines in human
macrophages as a factor of tumor promotion by TCDD
Kirill Kirsanov, Ekaterina Lesovaya, Natalia Shalginskikh, Denis Naberezhnov, Vladimir
Glazunov, Gennady Belitsky, Marianna Yakubovskaya (Blokhin Cancer Research Center,
Moscow, Russia) - Multiple mechanisms of DNA minor groove binding ligand epigenetic
effects
Oleg Kokorev, Valentina Hodorenko, Victor Gunther (Tomsk State University, Tomsk,
Russia) - Antitumor activity of allogeneic bone marrow cells immobilized in porouspermeable TiNi-based alloy scaffold
Daria Kokova, Natalia Dementeva, Nadezhda Cherdyntseva, Alexey Gratchev, Julia
Kzhyshkowska (Laboratory for translational cellular and molecular biomedicine, Tomsk
State University, Institute of Transfusion Medicine and Immunology, Medical Faculty
Mannheim, University of Heidelberg, 3Tomsk Cancer Research Institute) - Detection
adducts DNA in human blood and lung cancer tissue by a hybrid quadrupole time-offlight (Q-TOF) mass spectrometer
Sergey Kovalenko, Galina Paul, Natalya Matyash, Anton Kozyakov (Institute of Molecular
Biology and Biophysics, Biolink Ltd., Novosibirsk, Russia, Novosibirsk regional oncology
hospital, Novosibirsk, Russia) - Two-Years long genetic screening of breast cancer
patients in Novosibirsk (Russia) – first practical results
Tatyana Kunts, Ksenia Karpukhina, Elena Mikhailova, Nikolay Varaksin, Alexsandr
Autenshlyus (Novosibirsk State Medical University, Institute of Molecular Biology and
Biophysics, CJSC «Vector-best», Koltsovo, Novosibirsk, Russia)- Cytokine production by
malignant and benign breast tumors
Tatyana Kunts, Nikolay Varaksin, Alexandr Autenshlyus (Institute of Molecular Biology
and Biophysics, Novosibirsk, Russia)- Effect of polyclonal activators on cytokineproducing capacity of blood immunocompetent cells in adenoma and adenocarcinoma
of the stomach
Valeriia Kuzyk, Alexey Mittenberg (Institute of Cytology Russian Academy of Science, StPetersburg, Russia) - Analysis of proteasome-associated proteins in RPMI 8226 multiple
myeloma cell line under combined therapy
Olga Bryzgunova, Evgeniy Lekhnov, Tatiana Skvortsova, Evgeniy Morozkin, Ivan
Zaporozhchenko, Alina Grigorieva, Marat Zaripov, Elena Ryabchikova, Valentin Vlassov,
Pavel Laktionov (Institute of Chemical Biology and Fundamental Medicine SD RAS,
Novosibirsk Regional Oncology Center, Novosibirsk Research Institute of Circulation
Pathology of academician E.N. Meshalkin, Novosibirsk, Russia)- Use of extracellular RNA
from urine for the diagnosis of prostate cancer
Alla Leshchenko, Natalia Matsenko (BioLink Ltd., NRI MBB SB RAMS, Novosibirsk,
Russia)- The development of the test system for assessment of estrogen receptor status,
progesterone receptor, HER2/neu and the proliferative factor Ki67 in breast cancer by
real time PCR
Andrei Makashov, Andrei Kozlov (The Biomedical Center, Peter the Great St.Petersburg
Polytechnic University, St.Petersburg, Russia) - The human oncogenome evolution
advances ahead of the evolution of human protein-coding genome and other specific
gene classes
33 Ekaterina Matiunina, Andrei Kozlov, Alexander Emelyanov (The Biomedical Center,
Saint-Petersburg, Russia, Peter the Great St.Petersburg Polytechnic University, Institute for
Research on Cancer and Aging, Nice)- Evolutionary novel genes expressed in fish tumors
determine progressive evolutionary characters
11.07.2015 – 34A Lenin avenue, TSU Research Library
Poster session 2
34 Margarita Kruchinina, Andrey Starikov, Svetlana Kurilovich, Vladimir Kruchinin,
Vladimir Volodin, Sergey Rykhlitskii, Andrey Gromov, Sergey Peltec, Sergey Shehovtsov,
Vladimir Generalov (Institution of Internal and Preventive Medicine, Regional Oncology
Center, Rzhanov’s Institute of Semiconductor Physics Siberian Branch of Russian Academy
of Sciences, Institute of Cytology and Genetics of the Siberian Branch of the Russian
Academy of Sciences, Novosibirsk, Russia; The State Research Center of Virology and
Biotechnology VECTOR, Novosibirsk region, Russia) - Role of the optical methods for
blood study in staging of colorectal cancer
35 Darya Meshalkina, Maxim Shevtsov, Boris Margulis, Irina Guzhova (Institute of Cytology,
RAS, Saint-Petersburg, Russia) - Molecular chaperones Hdj1, Hdj2 and Hsp70 in model
glioma metastasis progression
36 Sandra Hofmann, Irina Bure, Abbas Agaimy, Arndt Hartmann, Florian Haller, Evgeny A.
Moskalev (Institute of Pathology, Friedrich Alexander University Erlangen-Nuremberg,
Erlangen, Germany) -Long non-coding RNA HOTAIR affects DNA methylation patterns
in gastrointestinal stromal tumours (GIST)
37 Tatiana Nikitenko, Oksana Rymar, Sofia Malyutina, Lilia Shcherbakova, Eugene Verevkin,
Svetlana Kurilovich (Federal State Budgetary of Scientific Institution «Institution of Internal
and Preventive Medicine», Novosibirsk, Russia) - Components of the metabolic syndrome
in patients with colorectal cancer: case-control study
38 Ekaterina Nikitina, Olga Cheremisina, Denis Kulbakin, Nikolay Litviakov (Tomsk Cancer
Research Institute, Tomsk State University, Tomsk, Russia) - MicroRNA-21, -155, -200c
and -205 in carcinogenesis of larynx
39 Nadezhda Palkina, Tatiana Ruksha (Krasnoyarsk State Medical University named after
Prof. V.F. Voino-Yasenetsky, Ministry of Public Health, Russia) - Matrix metalloproteinase
-9 and -13 as regulators of TGF-β-the signal transduction pathway in melanoma tumor
cells
40 Alexey Petukhov, Alexandra Daks, Oleg Shuvalov, Nikolaj Barlev (Institute of Cytology,
Russian Academy of Sciences, St. Petersburg, Russia) - Detection of COP1-interacting
proteins using co-immunoprecipitation followed MALDI-TOF mass spectrometry
41 Ekaterina Pisareva, Nadezhda Gutkina, Sergey Kovalenko, Vladimir Shamanin (Institute of
molecular biology and biophysics, BioLink Ltd., Novosibirsk, Russia) - Development of
allele-specific PCR assays for detection of mutations in KRAS gene in colorectal cancer
in Russian patients
42 Anastasia Ponomaryova, Elena Rykova, Nadezhda Cherdyntseva, Evgeny Morozkin, Ivan
Zaporozhchenko, Tatiana Skvortsova, Аlexey Dobrodeev, Alexander Zav’yalov, Sergey
Tuzikov, Valentin Vlassov, Pavel Laktionov (Tomsk Cancer Research Institute, Tomsk,
Russia, Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk,
Russia, National Research Tomsk Polytechnic University, Tomsk, Russia, National Research
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Tomsk State University, Tomsk, Russia) - Dynamic changes of circulating microRNA
expression in response to the lung cancer combined therapy
Dominika Pszczółkowska, Aleksandra Ellert-Miklaszewska, Anna Gieryng, Magdalena
Kijewska, Pawel Wiśniewski, Bożena Kamińska (Nencki Institute of Experimental Biology
Polish Academy of Sciences, Warszawa, Poland) - Glioma-derived osteopontin and
lactadherin shape tumormicroenvironment and immune response in rat model of
glioma
Ekaterina Rybalkina, Galina Pavlova, Natalia Moiseeva, Olga Susova, Aleksei Mitrofanov,
Dmitrii Panteleev, Nikolai Pustogarov (FSBI "N.N.Blokhin Russian Cancer Research
Center", Institute of Gene Biology of Russian Academy of Sciences, Moscow, Russia) Participation of the genes MVP/LRP and YB-1 in the determination of the rate of
sensitivity of glioblastoma cells to temodal
Yelena Shapovalova, Daria Lytkina, Liudmila Rasskazova, Anatoly Filimoshkin, Irina
Kurzina, Julia Kzhyshkowska (National Research Tomsk State University, Laboratory of
translational cellular and molecular biomedicine, Tomsk State University, Tomsk, Russia) Bioresorbable composites based on hydroxyapatite dispersed in Poly-L-lactide matrix
Elena Shashova, Elena Kolegova, Yulia Lyupina, Elena Slonimskaya, Irina Kondakova,
Nataliya Sharova (Tomsk Cancer Research Institute, Tomsk, Russia, Siberian State Medical
University, Tomsk, Russia, NK Koltsov Institute of Developmental Biology of Russian
Academy of Sciences, Moscow, Russia) - Features of proteasome system functioning in
the tumor and microenvironment cells of breast cancer
Sergei Shevchenko, Lyudmila Mostovich, Galina Logacheva, Svetlana Svyatchenko,
Lyudmila Gulyaeva (Novosibirsk State University, Institute of Molecular Biology and
Biophysics, SB RAS, Novosibirsk Municipal Clinical Hospital No.1, Novosibirsk, Russia) Integrin receptors and their ligands as potential biomarkers in preoperative diagnosis
of papillary thyroid carcinoma
Sergei Shevchenko, Lyudmila Mostovich, Nikolai Kolesnikov, Lyudmila Gulyaeva
(Institute of Molecular Biology and Biophysics SB RAMS, Novosibirsk Municipal clinical
Hospital № 1, Novosibirsk State University, Institute of Molecular and Cell Biology SB RAS,
Novosibirsk, Russia) - Molecular biomarkers in preoperative diagnosis of thyroid
cancer
Anna Silyutina, Sergei Zhuk, Pavel Butylin, Andrey Zaritskey (Institute of Hematology,
Federal North-West Medical Research Centre, Saint-Petersburg, Russia) - Macrophages
with JAK2V617F mutation are activated by platelets: role in pathogenesis of
myelofibrosis
Sergey Solodskikh, Viktor Bashmakov, Tatiana Gorbacheva, Anna Panevina, Alexander
Maslov, Andrei Mikhailov, Ivan Moshuro, Vasily Popov (Voronezh State University,
Voronezh Regional Clinical Oncology Center, Voronezh, Russia, Albert Einstein College of
Medicine of Yeshiva University, NY, USA) - Integrated analysis of genomic and
transcriptomic data in clear-cell renal cell carcinoma
Natalia Tarasenko, Liudmila Spirina, Evgeny Usynin, Alexei Gorbunov (The Research
Institute for Medical Genetics, Tomsk, Russia, Tomsk Cancer Research Institute, Tomsk,
Russia, Siberian State Medical University, Tomsk, Russia)- Genetic aspects of prostate
cancer development
Marina Stakheyeva, Alexandr Anufrak, Nadezhda Cherdyntseva, Julia Kzhyshkowska,
Vladimir Faltin, Sergey Avdeev (Tomsk Cancer Research Institute, Tomsk, Russia, Tomsk
State University, Tomsk, Russia, Department of Innate Immunity and Tolerance, Institute of
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Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University,
Germany) - The subsets of peripheral blood monocytes in cancer patients
Ekaterina Starostina, Denis Antonets, Elena Borobova, Larisa Karpenko, Alena Reguzova,
Olga Smirnova, Alexander Ilyichev, Sergei Bazhan (State Research Center of Virology and
Biotechnology “Vector”, Koltsovo, Novosibirsk region, Russia) - DNA-vaccines against
melanoma: design and investigation of antigenic properties
Svetlana Tamkovich, Oleg Tutanov, Alina Grigor’eva, Tatiana Duzhak, Natalia Kirushina,
Valentina Permyakova, Elena Ryabchikova, Vladimir Voicitsckyi, Valentin Vlassov, Pavel
Laktionov (Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk,
Russia, Novosibirsk State University, Novosibirsk, Russia, Institute of Tomografic Center SB
RAS, National Novosibirsk Regional Oncologic Dispensary, Novosibirsk, Russia, Central
Clinical Hospital, Novosibirsk, Russia) - Blood cell-surface-bound exosomes as a new
source of tumor-specific microRNA
Svetlana Tamkovich, Anna Bondar, Igor Morozov, Natalia Kirushina, Valentina
Permyakova, Vladimir Voitsitskiy, Pavel Laktionov (Institute of Chemical Biology and
Fundamental Medicine, Novosibirsk, Russia, Novosibirsk State University, Novosibirsk,
Russia, National Novosibirsk Regional Oncologic Dispensary, Novosibirsk, Russia, Central
Clinical Hospital, Novosibirsk, Russia)- The characterization of total circulating DNA
from blood of healthy donors and cancer patients
Leyla Tilova, Olga Zadorozhnaya, Alena Savinkova, Kirill Kirsanov, Anna Ogloblina,
Gennadiy Belitsky, Irina Budunova, Ekaterina Lesovaya, Marianna Yakubovskaya (Blokhin
Cancer Research Center, Department of Chemical Carcinogenesis, Moscow, Russia,
Northwestern University, Feinberg Medical School, Department of Dermatology, Chicago,
USA) - Synthesis and anti-cancer effects of CpdA enantiomers, non-steroidal
glucocorticoid receptor ligands
Alexandra Tsidulko, Liudmila Matskova, Lidiia Astakhova, Ingemar Ernberg, Elvira
Grigorieva (MTC, Karolinska Institute, Stockholm, Sweden, The Institute of Molecular
Biology and Biophysics, Novosibirsk, Russia, Kemerovo Institute of Food Science and
Technology, Kemerovo, Russia) - Proteoglycans expression correlates with the phenotype
of malignant and non-malignant EBV-positive B-cell lines
Matvei Tsyganov, Marina Ibragimova, Nikolay Litviakov, Nadezhda Cherdyntseva (Tomsk
Cancer Research Institute, Tomsk, Russia, National Tomsk State University, Tomsk, Russia) Microarray research of allelic imbalance in breast cancers during neoadjuvant
chemotherapy
Tamara Tyrinova, Alexander Ostanin, Sergey Mishinov, Lyudmila Sakhno, Sergey
Chernov, Vyacheslav Stupak, Elena Chernykh (Institute of Fundamental and Clinical
Immunology, Novosibirsk, Russia, Institute of Traumatology and Orthopedics, Novosibirsk,
Russia, Federal Neurosurgical Center, Novosibirsk, Russia)- Multiplex analysis of 27
cytokines produced by low-grade and high-grade glioma cells
Tamara Tyrinova, Olga Leplina, Marina Tikhonova, Sergey Mishinov, Sergey Chernov,
Lyudmila Sakhno, Vyacheslav Stupak, Elena Chernykh (Institute of Fundamental and
Clinical Immunology, Novosibirsk, Russia, Institute of Traumatology and Orthopedics,
Novosibirsk, Russia, Federal Neurosurgical Center, Novosibirsk, Russia)- Glioma-derived
soluble factors pose strong chemoattractants and parrtially change the cytotoxic
activity of IFN-alpha-induced dendritic cells
Ivan A Zaporozhchenko, Evgeny S Morozkin, Tatyana E Skvortsova, Elena Yu Rykova,
Anastasiya A Ponomareva, Nadezhda V Cherdyntseva, Evgeny S Polovnikov, Olga Yu
Anikeeva, Oksana A Pashkovskaya, Valentin V Vlassov, Pavel P Laktionov (Institute of
Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia, Novosibirsk
Research Institute of Circulation Pathology of E.N. Meshalkin, Novosibirsk, Russia, Tomsk
Cancer Research Institute, Tomsk, Russia) - Plasma microRNAs as noninvasive
biomarkers for diagnostics of lung cancer
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