Download ARVO 2016 Annual Meeting Abstracts 334 Eye and pregnancy

ARVO 2016 Annual Meeting Abstracts
334 Eye and pregnancy - Minisymposium
Tuesday, May 03, 2016 11:00 AM–12:45 PM
Skagit 4/5, TCC Minisymposium
Program #/Board # Range: 3463–3467
Organizing Section: Immunology/Microbiology
Contributing Section(s): Clinical/Epidemiologic Research, Cornea,
Lens, Physiology/Pharmacology, Retina
Program Number: 3463
Presentation Time: 11:00 AM–11:15 AM
Physiological changes during pregnancy and mode of delivery
Thomas Ness. Eye Center, University of Freiburg, Freiburg,
Germany.
Presentation Description: Pregnancy induces a lot of physiological
alterations to all body systems including the eye. Changes in
metabolism, hormons, circulation and fluid balance affect the eye.
Even if physiological ocular changes during pregnancy are common,
most likely they will be mild and transient.
Physiological changes can involve eyelids, tear film, cornea,
trabecular meshwork, immunity and crystalline lens. This leads to
refractive issues and problems wearing contact lenses. There are no
physiological alterations of the retina during pregnancy.
High myopia, lattice degeneration, glaucoma and previous intraocular
surgery are no contraindications to spontaneous vaginal delivery.
Commercial Relationships: Thomas Ness, MSD (R), Allergan (R),
Abbvie (R), Novartis (R), Bayer (R)
Program Number: 3464
Presentation Time: 11:15 AM–11:45 AM
Immunity during pregnancy
David Klatzmann1, 2. 1University of Pierre and Marie Curie, Paris,
France; 2Assistance Publique - Hôpitaux de Paris, Paris, France.
Presentation Description: Numerous modifications of the immune
system homeostasis are induced by pregnancy, such as to protect the
allogeneic fetus from immune rejection. This has profound effects on
immune responses in general, and on autoimmune and inflammatory
diseases that can improve or worsen during pregnancy.
We will review these aspects and their implication for eye infectious
and inflammatory pathologies
Commercial Relationships: David Klatzmann, None
systemic corticosteroids. The use of anti-vascular endothelial growth
factors are limited during pregnancy.
Commercial Relationships: Emily Y. Chew, None
Program Number: 3466
Presentation Time: 12:00 PM–12:15 PM
Uveitis in pregnancy
Lyndell L. Lim. Centre for Eye Research Australia, University of
Melbourne, Melbourne, VIC, Australia.
Presentation Description: Pregnancy is associated with various
hormonal and immunological changes that facilitate the survival of
the semi-allogenic foetus. These physiological changes influence
the course of various maternal autoimmune diseases, including
uveitis. Given that uveitis has a peak incidence in young adults, it
is not uncommon for female patients with known uveitis to become
pregnant. As many treatments for uveitis may have detrimental side
effects on the developing foetus, knowledge regarding the prognosis
of these patients’ eye disease during pregnancy will have important
implications on their management. This talk will discuss the effect
of pregnancy on the course of uveitis, based upon published clinical
studies in the field, and how this effect may vary depending on the
type of uveitis the patient may have.
Commercial Relationships: Lyndell L. Lim, Allergan (R), Abbvie
(R), Bayer (R), Novartis (F), Bayer (F)
Program Number: 3467
Presentation Time: 12:15 PM–12:45 PM
Prenatal exposure in pregnancy: what ophthalmologists need to
know
Christina D. Chambers1, 2. 1Pediatrics, University of California San
Diego, La Jolla, CA; 2Family Medicine and Public Health, University
of California San Diego, La Jolla, CA.
Presentation Description: In this presentation, attendees will be
given an overview of the known human teratogens and methods for
identifying them, with a particular focus on those agents that affect
eye development and function. Additionally, what is known about the
safety of medications used to treat ophthalmologic diseases during
pregnancy will be discussed.
Commercial Relationships: Christina D. Chambers, None
Program Number: 3465
Presentation Time: 11:45 AM–12:00 PM
Retina diseases in pregnancy
Emily Y. Chew. National Eye Inst/NIH, Bethesda, MD.
Presentation Description: During pregnancy, hematologic,
metabolic, hormonal, cardiovascular as well as immunologic
changes occur and retinal diseases may be affected through these
mechanisms. The most common retinal disease to be affected
during pregnancy is diabetic retinopathy as glycemic and blood
pressure control are affected markedly. Some of the risk factors
associated with progression of diabetic retinopathy and the course
of diabetic retinopathy during pregnancy will be discussed. Less
common retinal diseases that may be affected by pregnancy include
association with eclampsia (including hypertension). Other retinal
diseases including central serous chorioretinopathy and occlusive
retinal diseases (arterial and venous obstructions) may occur during
pregnancy. Inflammatory disease such as ocular histoplasmosis,
white dot symdromes, and others are pre-existing conditions that
may also be affected by pregnancy. The occurrence of chorioretinal
neovascularization during pregnancy can occur associated with othe
retinal diseaess or as idiopathic cases. The available therapies for
these conditions include laser photocoagulation, intravitreal and
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