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LIST OF ABBREVIATIONS LIST OF ABBREVIATIONS Abbreviation Description 1. µl Microlitre 2. µm Micrometer 3. λMax Absorbance Maxima (Wavelength) 4. µg/ml Microgram/Milliliter 5. A.A Acetic acid 6. ACN Acetonitrile 7. AUC Area under curve 8. BEH Bridged ethylene hybrid 9. CDER Center Of Drug Evaluation And Research 10. cGLP Current Good Laboratory Practices 11. cGMP Current Good Manufacturing Practices 12. cm Centimeter 13. Conc. Concentration 14. DOE Design of experiment 15. EC European Commission 16. FDA Food and drug administration 17. h Hour 18. H2O2 Hydrogen peroxide 19. HCl Hydrochloric acid 20. HETP Height equivalent to theoretical plates. 21. HPLC High performance liquid chromatography 22. HPTLC High performance thin layer chromatography 23. I.V. Intravenous 24. ICH International conference of harmonization 25. IS Internal standard i 26. ISO International Standards Organization 27. IU International units 28. IUPAC International union of pure and applied chemist 29. Kel Elimination rate constant 30. Ki Inhibition constant 31. Km Michaelis menten constant 32. LC Liquid chromatography 33. LC Liquid chromatography 34. LLOQ Lower limit of quantification 35. LC-MS/MS Liquid chromatography tandem mass spectrometry 36. LOD Limit of detection 37. LOQ Limit of quantification 38. m/z Mass to charge ratio 39. MeOH Methanol 40. mg Milligram 41. mg/ml Milligram/ milliliter 42. MI Metabolite intermediate 43. min Minute 44. MM Michaelis Menten 45. mm Millimeter 46. M Molarity 47. MRM Multiple reaction monitoring 48. MRT Mean residence time 49. MS Mass spectroscopy 50. MW Molecular weight 51. N Normality 52. NaCl Sodium chloride 53. NADPH Nicotinamide adenine dinucleotide phosphate 54. NCEs New chemical entities ii 55. ng Nanogram 56. nM Nanomolar 57. nm Nanometer 58. NMT Not More Than 59. ODS Octadecyl silane 60. PDA Photo diode array 61. P-gp P-glycoprotein 62. pH Negative logarithm of hydrogen ion concentration 63. PM Preventative maintenance 64. PAH Polycyclic aromatic hydrocarbon 65. QCs Quality control samples 66. R.S.D. Relative standard deviation 67. r2 Correlation coefficient 68. RE Relative error 69. Rep. Replicate 70. RH Relative humidity 71. RP Reverse phase 72. RRT Relative retention time 73. RT Retention time 74. SD Standard deviation 75. Sec Second 76. SIAM Stability indicating assay method 77. SNP Single nucleotide polymorphism 78. SSS System Suitability Samples 79. SST System Suitability Testing 80. Std. Standard 81. t1/2 Half life 82. TLC Thin layer chromatography 83. tmax Time of maximum concentration iii 84. UGTs Uridine diphosphoglucuronosyl transferases 85. UPLC Ultra performance liquid chromatography 86. US United State 87. USP United State of Pharmacopoeia 88. UV Ultra-Violet 89. v/v Volume/Volume 90. Vd Apparent volume of distribution 91. Vmax Maximal velocity of the reaction 92. w/v Weight by volume 93. W/w Weight/Weight 94. WHI Women’s Health Initiative 95. µg Microgram 96. µM Micromolar iv