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Causes CMT is caused by gene mutation that produce proteins that are involved . with the structure and function of either the peripheral nerve axon or the myelin sheath. Some forms of CMT are inherited in an autosomal dominant and autosomal recessive fashion. Depending on the Type there can be a mutation on chromosome 17 or in Mitosis 2. Symptoms Affects both motor and sensory nerves. Weakness of the foot and lower leg muscles. Foot drop High stepped gait. “inverted change bootleg” appearance in the legs. Eventually CMT affects the hands and legs becoming difficult to lift or grasp things. History CMT is one of the most common inherited neurological disorders. It is named after the 3 physicians who first identified it in 1886: Jean- Martin Charcot, Pierre Marie, and Howard Henry Tooth. CMT, also know as hereditary motor and sensory neuropathy affects the peripheral nerves. Diagnosis/Tests Complete medical/ family/and neurological test Test for muscle weakness in the extremities One specific sign found in CMT patients is enlarged nerves Nerve Biopsy A electrodiagnostic test which sends electrical shock to stimulate the sensory/ motor nerves. Treatment Physical Therapy-To strengthen muscle Braces to prevent injury to ankle or legs Orthopedic devices High top boots are shoes are used to prevent injury and support the ankle. Mutations in the GDAP1 gene X-tra Innings There is NO CURE for CMT, only management for the symptoms Research is being done to ID the gene mutations and proteins that cause this disease. Progression of symptoms is gradual CMT is NOT fatal and has normal life expectancy Experiments in gene therapy or replacement is being conducted There are test that can be done to test eggs/ References: http://brain.oxfordjournals.o rg www.ncbi.nlm.nih.gov www.ninds.nih.gov › Disorders A - Z › CharcotMarie-Tooth Disorder