Download Physicians Database Login

UNIVERSITY OF MIAMI
Curriculum Vitae
DATE: 6/8/08
I. PERSONAL
2. Name: Juan Pablo Zambrano. MD. FACC
3. Cell Phone: Private
4. Office Phone: 305 585 7561
5. Home Address: Private
Work: 1120 NW 12th St. Suite 1110, Miami, FL, 33136
6. Current Academic Rank: Assistant Professor
6a. Current Track of Appointment: clinical track
7. Primary Department: Medicine
8. Secondary or Joint Appointments: Cardiology, Interventional Cardiology for
UM/JMH/VAMC
9. Citizenship: US Citizen
II. HIGHER EDUCATION
6/1995-6/1997
5/1994-5/1995
5/1987-5/1995
5/1981-5/1987
5/1975-1/1981
Social Service at The Instituto de Cardiologia Alfredo Palacio,
Guayaquil, Ecuador
Externship at University of Miami (Ob-Gyn, Surgery, Pediatrics
and Internal Medicine) through the J.W. Harrington Latin
American Training Program
Medical School: Universidad Catolica Santiago de Guayaquil,
Guayaquil, Ecuador
Middle and High School: Colegio Jesuita Javier, Guayaquil,
Ecuador
Elementary School: Colegio Salesiano Cristobal Colon, Guayaquil,
Ecuador
Postdoctoral training
7/2004-7/2005
Interventional Cardiology Fellowship: University of Miami,
Jackson Memorial Hospital, VAMC, Miami, Florida
7/2001-6/2004
Cardiology Fellowship: University of Miami, Jackson Memorial
Hospital, VAMC, Miami, Florida
6/2000-6/2001
Medical Chief Resident: VAMC, University of Miami, Miami,
Florida
Internship and Residency: University of Miami, Jackson Memorial
Hospital, VAMC, Miami, Florida
7/1997-6/2000
Licensure/Certification
Florida License ME80831
Internal Medicine Board Certified 2001
Nuclear Cardiology License
Cardiology Board Certified 2005
Nuclear Cardiology Board Certified 2005
ACLS/BLS Certified 2008
Interventional Cardiology Board Certification 2006
III. EXPERIENCE
2/2007-Present
Assistant Professor of Medicine, Division of CardioVascular
Medicine, Cardiovascular Interventionalist and Stem Cell Research
Institute Member
7/2005-2/2007
Garcia & Pastoriza PA Cardiology Group. Clinical and
Interventional Cardiology at Kendall Regional Medical Center,
Baptist Hospital and South Miami Hospital. Miami, Florida
8/2004-6/2005
Intensive Care Unit physician at Memorial West Hospital.
Pembroke Pines, Florida
1/2003-6/2004
Intensive Care Unit physician at Memorial Regional Hospital.
Hollywood, Florida
10/2000-6/2005
Intensive Care Unit physician at West Palm Beach VA, Florida
10/2000-10/2004
Emergency Room physician at the Miami VA, Florida
6/2000-6/2001
Ward Attending for Internal Medicine at the Miami VA, Florida
5/1995-5/1997
Cardiology Resident at Instituto Nacional de Cardiologia Alfredo
Palacio (INCAP), Guayaquil, Ecuador
IV. PUBLICATIONS
(1) Published Papers in Peer Reviewed Journals
 Evaluation of comorbidity scores to predict all-cause mortality in patients with
established coronary artery disease. Int J Cardiol. 2006 Jul 11 Chirinos JA,
Veerani A, Zambrano JP, Schob A, Perez G, Mendez AJ, Chakko S.
 Is TEE useful in patients with small subcortical strokes? Eur J Neurol. 2006
May;13(5):522-7.. Rabinstein AA, Chirinos JA, Fernandez FR, Zambrano JP.
 Ability of serum to decrease cellular acylCoA:cholesterol acyl transferase activity
predicts cardiovascular outcomes.Circulation. 2005 Oct 18;112(16):2446-53.
Chirinos JA, Zambrano JP, Chakko SC, Schob A, Goldberg RB, Perez GO,
Mendez AJ.
 Relation between ascending aortic pressures and outcomes in patients with
angiographically demonstrated coronary artery disease.Am J Cardiol. 2005 Sep
1;96(5):645-8. Chirinos JA, Zambrano JP, Chakko S,; Veerani A, Schob A;
Perez G, Mendez A.
 Correlation between apoptotic endothelial microparticles and serum interleukin-6
and C-reactive protein in healthy men. Am J Cardiol. 2005 May 15;95(10):125860. Chirinos JA; Zambrano JP; Jimenez J; Jy W; Virani S, MD; Ahn E,
Horstman LL; Castellanos A Myerburg RJ; Ahn YS.
 Aortic pressure augmentation predicts adverse cardiovascular events in patients
with established coronary artery disease.Hypertension. 2005 May;45(5):980-5.
Julio A. Chirinos JA, Zambrano JP, Chakko S,; Veerani A, Schob A; Perez G,
Mendez A.
 Usefulness of C-Reactive Protein (CRP) is an independent predictor of death in
Patients with Ischemic Cardiomyopathy. Submitted to American Journal of
Cardiology2005;95(1):88-90. Chirinos JA, Zambrano JP, Chakko S, Schob A,
Veerani A, Perez GO, Mendez AJ.
 Elevation of Endothelial Microparticles, platelet and leukocyte activation in
patients with Venous Thromboembolism. JACC 2005;45:1467-71. Julio A.
Chirinos, MD; Gustavo A. Heresi, MD; Hermes Velasquez, MD; Wenche Jy,
PhD; Joaquin J. Jimenez, MD; Eugene Ahn, MD; Lawrence L. Horstman, BS;
Andres O. Soriano, MD; Juan P. Zambrano, MD; Yeon S. Ahn, MD
 Digoxin use is associated with increased platelet and endothelial cell activation in
patients with non-valvular atrial fibrillation. Heart Rhythm 2005;2:525-529. Julio






A. Chirinos, MD; Aurelio Castrellon, MD; Zambrano JP, MD; Wenche Jy, PhD,
Larry Horstman, MS; Joaquin Jiménez, MD; Howard Wellens, MD; Agustin
Castellanos, MD Robert J. Myerburg; MD; Yeon Ahn, MD
Body mass index is not a risk factor for unstable angina and myocardial infarction
in veteran patients with angiographically confirmed coronary artery disease.
Circulation. 2004 May 11;109(18):e215-6. Chirinos JA, Zambrano JP, Veerani
A.
Noncompaction of the Ventricular Myocardium: The Use of Contrast-Enhanced
Echocardiography in Diagnosis. Journal of the American Society of
Echocardiography 2003 Jan; 16: 94-96. Lowery MH, Martel JA, Zambrano JP,
Ferreira A, Eco L, Gallagher A.
Images in cardiovascular medicine: Left bundle-branch block with technical rightaxis deviation. Circulation. 2002 Oct 22;106(17):2288-9. Castellanos A, Pastor
JA, Zambrano JP, Myerburg RJ.·
Percutaneous stenting of bilateral pulmonary artery stenosis caused by malignant
extrinsic compression. Chest. 2002 Oct;122(4):1478-80. Fierro-Renoy C,
Velasquez H, Zambrano JP, Ridha M, Kessler K, Schob A.
Mechanical Reperfusion during Acute Myocardial Infarction in a Patient with
Dextrocardia. Journal of Invasive Cardiology.. Zambrano JP, De la Hera, De
Marchena E.
Platelet Activation Promotes Formation Of Platelet-Leukocyte Conjugates (PLC)
In Non-Valvular Atrial Fibrillation (AF). Blood . In Press. Castrellon A, Chirinos
JA, Zambrano JP, Jy W, Horstmann LL, Ahn ER, Jimenez JJ, Willens H,
Castellanos A, Myerburg RJ, Ahn YS
(2) Texbook Chapters



Is hs-CRP Ready for "Prime Time" As A Prognostic Risk Factor For
Cardiovascular Disease? Editorial, Hurst The Heart (Web Page) Chapter 38:
Dyslipidemia, other Risk Factors, and the Prevention of Coronary Heart Disease.
2003. Zambrano JP, Munoz O, O’Rourke R
Endothelial Function Chapter 6, Interventional Cardiology Secrets, Hanley and
Belfus Inc (An Imprint of Elsevier) 2003
Stages of Coronary Atherosclerosis Chapter 7, Interventional Cardiology Secrets,
Hanley and Belfus Inc (An Imprint of Elsevier) 2003
(3) Published Abstracts

Carotid Artery Stenting Registry in High-risk Patients with Carotid Stenosis Miami Veterans Administration Hospital Experience. Submitted TCT 08
Abstract. Alfonso, Carlos E.; Toledo, Yeraldine; Pascual, Mario; Bhatt, Mehul;
Diaz, Miguel A.; Zambrano, Juan Pablo; Reyes-Iglesias, Yolanda; Schob, Alan.
Department of Medicine, Division of Cardiology, University of Miami Miller
School of Medicine Miami, Florida, Miami Veterans Administration Hospital
Miami, Florida.

The Impact Of Intravenous Allogeneic Human Mesenchymal Stem Cells
(Provacel™) On Ejection Fraction In Patients With Myocardial Infarction. Circ.
2007; A1014. Zambrano J, Traverse J, Henry T, Dib N, Strumpf R, Schulman S,
Gerstenblith G, DeMaria A, Denktas A, Gammon R, Hermiller J, Reisman M,
Schaer G, Sherman W, Tamariz L, Hare J.

Cardiac Chimerism Following Intramyocardial Mesenchymal Stem Cell
Transplantation. JACC 2007. Hatzistergos K, Quevedo H, Oskouei B, Zambrano
J, Qinghua H, Mazhari R, Helman A, McNiece I,Hare J.

Mesenchymal Stem Cell Therapy Restores Cardiac Stem Cell Niches alter Acute
Myocardial Infarction. Circ. Res. 2007; 101;1204-11 A 4016.Chatzistergos K,
Quevedo H, Oskouei B, Qinghua H, Mazhari R, Revilla C, Zambrano J,
McNiece I, Heldman A, Hare J. Stem Cell Institute, Div of Cardiology UM Miller
School of Medicine.
Correlation between apoptotic endothelial microparticles and Subclinical
Inflammation in healthy individuals. Journal of the American College of
Cardiology. ACC 44 Meeting. March 2005. Chirinos JA; Zambrano JP; Jimenez
J; Jy W; Virani S, MD; Ahn E, Horstman LL; Castellanos A Myerburg RJ; Ahn
YS.
Digoxin use is associated with increased platelet and endothelial cell activation in
patients with non-valvular atrial fibrillation. Journal of the American College of
Cardiology. ACC 44 Meeting. March 2005. Julio A. Chirinos, MD; Aurelio
Castrellon, MD; Zambrano JP, MD; Wenche Jy, PhD, Larry Horstman, MS;
Joaquin Jiménez, MD; Howard Wellens, MD; Agustin Castellanos, MD Robert J.
Myerburg; MD; Yeon Ahn, MD
Elevation of Endothelial Microparticles, platelet and leukocyte activation in
patients with Venous Thromboembolism. Journal of the American College of
Cardiology. ACC 44 Meeting. March 2005. Julio A. Chirinos, MD; Gustavo A.
Heresi, MD; Hermes Velasquez, MD; Wenche Jy, PhD; Joaquin J. Jimenez, MD;
Eugene Ahn, MD; Lawrence L. Horstman, BS; Andres O. Soriano, MD;
Zambrano JP, MD; Yeon S. Ahn, MD
C-Reactive Protein (CRP) is an independent predictor of death in Patients with
Cardiomyopathy. Heart Failure Society of America Meeting 2004. Chirinos JA,
Zambrano JP, Chakko S, Schob A, Veerani A, Perez GO, Mendez AJ.










High-density Lipoprotein-Mediated cholesterol efflux from cells is a strong
independent predictor of cardiovascular risk. Journal of the American College of
Cardiology. ACC 43 (5). March 2004: 463A. Chirinos JA, Zambrano JP,
Chakko SC, Schob A, Perez GO, Mendez AJ.
Digoxin use is associated with increased platelet and endothelial cell activation in
patients with non-valvular atrial fibrillation. Heart Rhythm. 2004 May;27(S5).
Chirinos JA, Castrellon A, Zambrano JP, Willens H, Castellanos A, Myerburg
RJ, Ahn YS
Elevated Endothelial Microparticles (EMP) and Activation Markers of Platelets
and Leukocytes in Venous Thromboembolism (VTE). Blood 102 (11), November
16, 2003. Heresi GA, Chirinos JA, Velasquez H, Zambrano JP, Soriano AO,
Horstman LL, Jy W, Ahn YS.
Is TEE useful in patients with small subcortical strokes?. Neurology 62(S5):
A173. Rabinstein AA, Chirinos JA, Fernandez FR, Zambrano JP
C-Reactive Protein and The Prediction of Cardiovascular Events in Patients with
Documented Coronary Artery Disease: Effects of Aspirin and Statin Therapy.
Journal of Investigative Medicine 2004 Jan; 52 (1): A25. Zambrano JP, Chirinos
JA, Tamariz LJ, Palacio A, Chakko S, Schob A, Perez GO, Mendez AJ.
Correlation of High Sensitivity C-Reactive Protein with The Severity and Extent
of Coronary Artery, Presented at Florida Chapter of the ACC, Young
Investigator Competition. FCACC Newsletter 2001 Zambrano JP, Chirinos JA,
Hermes Flores, Chakko S, Schob A, Perez GO, Mendez AJ
(4)Miscellaneous
Other Abstracts

Carotid Artery Stenting Registry in High-risk Patients with Carotid Stenosis Miami Veterans Administration Hospital Experience. Miami International
Revascularization Summit (MIRS) April 2008, Miami Beach, Fl. Alfonso, Carlos
E.; Toledo, Yeraldine; Pascual, Mario; Bhatt, Mehul; Diaz, Miguel A.;
Zambrano, Juan Pablo; Reyes-Iglesias, Yolanda; Schob, Alan. Department of
Medicine, Division of Cardiology, University of Miami Miller School of
Medicine Miami, Florida, Miami Veterans Administration Hospital Miami,
Florida.

Allogeneic Mesenchymal Stem Cell therapy in a chronic model of myocardial
infarction. Presented at the 1st Clinical Disease Forum Annual Meeting at UM
Miller School of Medicine 2008, Miami, Fl. Hatzistergos K, Quevedo H, Oskouei
B, Zambrano J, Qinghua H, Mazhari R, Helman A, McNiece I,Hare J
Mesenchymal stem cell transplantation after acute myocardial infarction:
Mechanisms of cardiac repair. Presented at the International Society of Cellular
Therapy 2008, Miami, Fl. Hatzistergos K, Quevedo H, Oskouei B, Zambrano J,
Qinghua H, Helman A, McNiece I,Hare J






Influence of TEE in the Treatment of Important Sources of Emboli in Acute
Stroke, Presented at the Research Scholarly Activity Program of Internal
Medicine Dept. 1999 Zambrano JP, Andrade S, Bauerlein Joseph
Myocardial Perfusion imaging in Coronary Disease in Patients with Combined
RBBB and LAFB, Presented in the Scientific Assembly and Annual Meeting of
the radiological Society of North America, Chicago, Illinois, 1995. Ezudin S,
Zambrano JP
Assessment of the of the Immunocompromised Patient, Presented at the Nuclear
Oncology Congress: Advances in diagnostic and therapeutic applications, Key
Biscayne 1995 Ganz W, Zambrano JP
Use of Viabahn Stent-grafts as an Adjunct to Superficial Femoral Artery
Angioplasty for Limb Salvage. Miami International Revascularization Summit
(MIRS) Feb 2005. Kenneth Zelnick, Hassan Tehrani, Alan Schob, Pranay
Ramdev, Zambrano JP, Cesar Jara, Darwin Eton.
Serum-mediated intracellulat efflux cholesterol activity predicts cardiovascular
outcomes. Finalist Session, Young Investigator Awards Comptetition. Annual
Meeting of the Florida Chapter of the American College of Cardiology.
September 17-19, 2004. Miami, Florida. Chirinos JA, Zambrano JP, Chakko SC,
Schob A, Perez GO, Mendez AJ:
Presented outside USA
At the National Congress of Cardiology, Guayaquil, Ecuador 1995




Prevalence of ASA in 357 Pts with Congenital Heart Disease. Transesophageal
echocardiography
Correlation between Signal Average ECG and Left Ventricular Mass in Patients
with Hypertension
Carotid Artery Evaluations in Patients with Cardiac and Neurologic abnormalities
Efficacy of TEE in the Detection of Intracardiac Thrombi Missed by
Transthoracic Echocardiography
At the South American Congress of Cardiology, Quito, Ecuador 1993








Patent Ductus Arteriosus in Guayaquil I Study
Profile and frequency of Tetralogy of Fallot in 375 Children with Congenital
Hearth Diseases
The Ventricular Septal Defects of the Guayaquil I Study
Distribution of Congenital Heart Disease in the Guayaquil I Study
The Atrial Septal Defect in the Congenital Heart Disease Population of the
Guayaquil I Study
Cardiac Involvement in Systemic Hypertension and Aging
Is the Age a Coronary Risk Factors
Risk Factors and Ischemic Heart Disease Before and After the Age of 50


Consequences and Risks of Left Ventricular Hypertrophy
Primary Pericardial Lymphoma: Case Report
University Journal



The amazing endothelium. Revista INCAP, Biannual publication 1998
What happens to the Myocardial Cells during ischemia? Meta Cientifica
(University Journal) 1:3 1991
Molecular Mechanisms of the cathecolamines. Meta Cientifica (University
Journal) 1:2 1990
V. PROFESSIONAL AND TEACHING
2008- Organizer of the First International Cardiovascular Conferences University of
Miami Miller School of Medicine and Universidad Espiritu Santo in Guayaquil-Ecuador
2008- Team Leader for the Creation of the University of Miami Cardiology Consult
Service
2007-8- Cardiology Grand Rounds Cardiovascular division, UM Miller School of
Medicine: Clinical Approach to Peripheral Vascular Disease
2008- Lecturer for the Cardiovascular System Module for freshman medical students UM
Miller School of Medicine, Topic: Peripheral Vascular Disease
2008 to Present- Co-Director of the 6th Annual MIRS (Miami International
Revascularization Summit)
2007 to Present- Establishment of Multidisciplinary Vascular Meetings Bi monthly at the
VAMC with the participation of Cardiovascular Medicine, Vascular Surgery, Wound
Care, Podiatry and Prevention of Amputation Team for case review and discussion
2007 to Present- Weekly Interventional Cardiology Conferences
2007 to Present- Committee of interview for new recruits in the Division of
CardioVascular Medicine.
2007 to Present- Development of the CardioVascular Peripheral Interventional Program
within the Division of CardioVascular Medicine for UM/JMH/VAMC
2007 to Present-Research in Myocardial Regeneration using Mesenchymal Stem Cells in
large animal models (porcine model) and human research (Co-Investigator for
Prometheus and
2007 to Present- Part of the STEMI Alert Team for JMH and VAMC
2007-Fellow of the American College of Cardiology (F.A.C.C)
2007- Invited speaker to Jornadas Medicas Internacionales Universidad Catolica Santiago
de Guayaquil, Ecuador
2006- Invited speaker to Jornadas de Atherosclerosis, Sociedad Ecuatoriana de
Cardiologia
2004-Best Cardiology Fellow in the Departement of Cardiology, University of Miami,
Florida
2002-Best Subspecialty Fellow in the Department of Medicine, University of Miami,
Florida
2001-Finalist in Young Investigator Award at the Florida Chapter of The ACC
2000-ACP/ASIM Chief Medical Resident Award
1995-1996 Instructor Assistant in Cardiology Courses, Universidad Catolica Santiago de
Guayaquil, Ecuador
1991-1993 Winner of Contest for Instructor in Parasitology and Mycology, Universidad
Catolica Santiago de Guayaquil, Ecuador
Doctoral Thesis: “Specificity of Thallium Stress Test in Patients With RBBB and LAH”
Trainned in Peripheral Endovascular Therapy during Interventional Fellowship at
JMH/VAMC