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Anti-DCP1A (aa 225-275) polyclonal antibody Cat.No: DPABH-23374 Lot. No. (See product label) PRODUCT INFORMATION Antigen Description Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. Immunogen Synthetic peptide, corresponding to a region within amino acids 225-275 of Human Dcp1a (NP_060873.4). Isotype IgG Source/Host Rabbit Species Reactivity Human Purification Immunogen affinity purified Conjugate Unconjugated Applications WB, IP Format Liquid Size 100 μg Buffer Constituent: 99% Tris citrate/phosphate. Note: pH 7 to 8 Preservative Preservative: 0.09% Sodium azide Storage Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. Antigen Gene Information Gene Name DCP1A DCP1 decapping enzyme homolog A (S. cerevisiae) [ Homo sapiens ] Official Symbol Dcp1a Synonyms DCP1A; DCP1 decapping enzyme homolog A (S. cerevisiae); mRNA-decapping enzyme 1A; HSA275986; SMAD4IP1; SMIF; decapping enzyme hDcp1a; transcription factor SMIF; putative protein product of Nbla00360; Smad4-interacting transcriptional co-activator; Nbla00360; FLJ21691; Entrez Gene ID 55802 mRNA Refseq NM_018403 Protein Refseq NP_060873 MIM 607010 UniProt ID Q9NPI6 Chromosome Location 3p21.1 Creative Diagnostics. All rights reserved 45-1 Ramsey Road Shirley, NY 11967, USA Tel: 1-631-624-4882 Fax: 1-631-938-8221 E-mail: [email protected] www.creative-diagnostics.com 1 Pathway Deadenylation-dependent mRNA decay; Decapping complex; Destabilization of mRNA by Butyrate Response Factor 1 (BRF1); Destabilization of mRNA by Tristetraprolin (TTP); Gene Expression; RNA degradation; Function hydrolase activity; identical protein binding; protein binding; Creative Diagnostics. All rights reserved 45-1 Ramsey Road Shirley, NY 11967, USA Tel: 1-631-624-4882 Fax: 1-631-938-8221 E-mail: [email protected] www.creative-diagnostics.com 2