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PowerPoint® Lecture Outlines prepared by Dr. Lana Zinger, QCCCUNY 12 Cardiovascular Disease and Cancer Copyright © 2011 Pearson Education, Inc. Cardiovascular Disease: An Epidemiological Overview Cardiovascular Disease (CVD) • Cardiovascular disease is the cause of 37 percent of all deaths in the United States. • For all ages combined, CVD is the leading cause of death. • More than 80 million Americans—1 out of every 3 adults—will have some type of CVD. • The best defense against CVD is to prevent it from developing in the first place. Do you know someone who has had a heart problem? Copyright © 2011 Pearson Education, Inc. Prevalence of Cardiovascular Diseases (CVDs) in Adults Aged 20 and Older by Age and Sex Copyright © 2011 Pearson Education, Inc. Understanding the Cardiovascular System The Heart: A Mighty Machine • Four chambers • Two upper chambers are called atria • Two lower chambers are called ventricles • Valves regulate the flow of blood. Copyright © 2011 Pearson Education, Inc. Blood Flow within the Heart Copyright © 2011 Pearson Education, Inc. Understanding the Cardiovascular System Heart Function • Deoxygenated blood enters the right atrium • From the right atrium, blood travels to the right ventricle • Blood is pumped through the pulmonary artery to the lungs, where it receives oxygen • Oxygenated blood from the lungs returns to the left atrium of heart • Blood from the left atrium moves into the left ventricle • The left ventricle pumps blood through the aorta to all body parts Copyright © 2011 Pearson Education, Inc. Percentage Breakdown of Deaths from Cardiovascular Disease in the United States Copyright © 2011 Pearson Education, Inc. Cardiovascular Disease Atherosclerosis (CAD— coronary artery disease) • Arteriosclerosis • Hyperlipidemia • Inflammatory risk • Peripheral artery disease (PAD) Coronary Heart Disease (CHD) • Greatest killer • Myocardial infarction (MI) or heart attack Copyright © 2011 Pearson Education, Inc. Atherosclerosis and Coronary Heart Disease Copyright © 2011 Pearson Education, Inc. Cardiovascular Disease Angina Pectoris • Ischemia—condition that reduces the heart’s blood and oxygen supply • People with ischemia often suffer angina pectoris, or chest pain and pressure. • Treatments include calcium channel blockers or betablockers Arrhythmias • Irregularity in heart rhythm • Fibrillation • Over 4 million Americans have experienced some type of arrhythmia Copyright © 2011 Pearson Education, Inc. Cardiovascular Disease Congestive Heart Failure (CHF) • Affects over 5 million Americans • Single most frequent cause of hospitalization in United States Stroke • 6.5 million Americans suffer strokes every year • Blood supply to brain is interrupted • Transient ischemic attacks (TIAs) are brief interruptions of the blood supply to the brain that cause temporary impairment. • Today, stroke is a leading cause of serious long-term disability and contributes a significant amount to Medicaid and Medicare expenses for older Americans, particularly women. Copyright © 2011 Pearson Education, Inc. ABC News Video: Heart Disease in America | Heart Disease in America Discussion Questions 1. What preventive measures can be taken to avoid a heart attack? 2. What effect does a celebrity death from a certain illness have on how members of the public address their own health? Copyright © 2011 Pearson Education, Inc. Reducing Your Risks Metabolic Syndrome: Quick Risk Profile • For a diagnosis of metabolic syndrome, a person would have three or more of the following risks: • Abdominal obesity • Elevated blood fat (triglycerides greater than 150 units) • Low levels of HDL (“good”) cholesterol • Elevated blood pressure greater than 130/85 mm/Hg • Elevated fasting glucose greater than 100 mg/dL • High levels of C-reactive proteins Copyright © 2011 Pearson Education, Inc. Reducing Your Risks Modifiable Risks • Avoid tobacco. • Cut back on saturated fats and cholesterol. • Low-density lipoproteins (LDL) • High-density lipoproteins (HDL) • Triglycerides • Maintain a healthy weight. • Exercise regularly. • Control diabetes. • Control blood pressure. • Manage stress. Copyright © 2011 Pearson Education, Inc. Recommended Cholesterol Levels for Adults Copyright © 2011 Pearson Education, Inc. Blood Pressure Classifications Copyright © 2011 Pearson Education, Inc. Reducing Your Risks Nonmodifiable Risks • Race and ethnicity • Heredity • Age • Gender Other Risk Factors Being Studied • Inflammation and C-reactive protein • Homocysteine Copyright © 2011 Pearson Education, Inc. Weapons against Cardiovascular Disease Techniques for Diagnosing Cardiovascular Disease • Electrocardiogram (ECG) • Angiography • Positron emission tomography (PET) scan • Magnetic resonance imaging (MRI) • Ultrafast computed tomography (CT) scan • Cardiac calcium score Copyright © 2011 Pearson Education, Inc. Weapons Against Cardiovascular Disease Bypass Surgery and Angioplasty • Coronary bypass surgery helps patients who suffer from coronary blockages of heart attacks. • In bypass surgery, a blood vessel is taken from another site in the patient’s body and implanted to “bypass” blocked coronary arteries. • Angioplasty uses a balloon to open the artery to allow blood to flow more freely. • Angioplasty carries fewer risks and may be more effective in selected cases than bypass surgery. Copyright © 2011 Pearson Education, Inc. Weapons against Cardiovascular Disease Can Aspirin Help Heart Disease? • Low doses of aspirin (75 to 81 mg) daily or every other day can be beneficial to heart patients • Blood-thinning properties • Risks may outweigh the benefits Copyright © 2011 Pearson Education, Inc. An Overview of Cancer • Second leading cause of death in the United States • 1.5 million new cases diagnosed every year • Early detection and improvements in technology have improved prognosis for many. Why do you think the rate of cancer is so high in the U.S. today? Copyright © 2011 Pearson Education, Inc. An Overview of Cancer What Is Cancer? • Uncontrolled growth and spread of abnormal cells • Neoplasms • Malignant tumors • Benign tumors Copyright © 2011 Pearson Education, Inc. Metastasis Copyright © 2011 Pearson Education, Inc. What Causes Cancer? Lifestyle Risks • Tobacco use • Poor nutrition, physical inactivity, and obesity • Stress and psychosocial risks Genetic and Physiological Risks • Genetic predisposition • Oncogenes—cancer-causing gene that typically stays dormant but can be activated • Biological sex • Reproductive and hormonal risks Copyright © 2011 Pearson Education, Inc. Probability of Developing Invasive Cancers during Selected Age Intervals by Sex, United States 2003-2005 Copyright © 2011 Pearson Education, Inc. What Causes Cancer? Occupational and Environmental Risks • Exposure to asbestos, nickel, chromate, and benzene • Exposure to radioactive substances • Chemicals in foods • Medical treatment risks Infectious Diseases and Cancer • Hepatitis B and hepatitis C • Liver cancer • Human papillomavirus and cervical cancer Copyright © 2011 Pearson Education, Inc. Go Green against Cancer To Reduce the Number of Carcinogens • Leave your car at home. • Choose organic foods when possible. • Shop for ecofriendly home furnishings. • Turn off your lights when you leave a room. • Use “green” paper. • Buy ecofriendly hygiene products. • Avoid dry cleaning. Copyright © 2011 Pearson Education, Inc. Types of Cancer Categories of Cancer • Carcinomas • Sarcomas • Lymphomas • Leukemias Lung Cancer • Cause of death of 159,390 Americans in 2009 • Symptoms include a persistent cough, blood-streaked sputum, chest pain, and recurrent attacks of pneumonia or bronchitis • Hazards of secondhand smoke Copyright © 2011 Pearson Education, Inc. Leading Sites of New Cancer Cases and Deaths, 2009 Estimates Copyright © 2011 Pearson Education, Inc. Types of Cancer Breast Cancer • Approximately 192,370 women and 1,910 men were diagnosed in 2009 • Risk increases with age • Risk factors supported by research • Prevention (self-exam and mammography) • Treatment • Surgical • Selective estrogen-receptor modulators (SERMs) Copyright © 2011 Pearson Education, Inc. Breast Awareness and Self-Exam Copyright © 2011 Pearson Education, Inc. Types of Cancer Colon and Rectal Cancer • Third most common cancer in men and women • 146,970 cases were diagnosed in 2009 • Warning signals include blood in the stool and rectal bleeding. Skin Cancer • Affects over 1 million people every year • Treatable: basal or squamous • Virulent: malignant melanoma • ABCD rule about melanoma • Asymmetry • Border irregularity • Color • Diameter Copyright © 2011 Pearson Education, Inc. Types of Skin Cancers Copyright © 2011 Pearson Education, Inc. ABC News Video: Possible Melanoma Treatment | Possible Melanoma Discussion Questions 1. Do scientific successes against cancer cause your worry about getting cancer to decrease? 2. What do you do to protect yourself from skin cancer? Could you do more? Copyright © 2011 Pearson Education, Inc. Types of Cancer Prostate Cancer • Most frequently diagnosed cancer in American males today, excluding skin cancer, and is the second leading cause of cancer deaths in men after lung cancer • 192,280 new cases were diagnosed in 2009. • Estimated 1 in 33 men will die from prostate cancer in his lifetime Ovarian Cancer • Fifth leading cause of death in women • 21,550 new cases were diagnosed in 2009. • Enlargement of the abdomen is a common warning sign • Prevention: annual pelvic exams Copyright © 2011 Pearson Education, Inc. Types of Cancer Cervical and Endometrial (Uterine) Cancer • Regular Pap tests are crucial for early detection • Risk: early onset of intercourse • Warning: abnormal bleeding Testicular Cancer • Ages 15 to 35 are at the greatest risk • Cause is unknown • Men with undescended testicles appear to be at the greatest risk Copyright © 2011 Pearson Education, Inc. Testicular Self-Exam Copyright © 2011 Pearson Education, Inc. Facing Cancer Detecting Cancer • The earlier the cancer is diagnosed, the better prospect there is for survival • Practice self-exam and checkups • Several high-tech tools have been developed to help detect cancer • Magnetic Resonance Imaging (MRI) • Computerized axial tomography scanning (CT scan) Copyright © 2011 Pearson Education, Inc. Screening Guidelines for the Early Detection of Cancer in Average-Risk Asymptomatic People Continued Copyright © 2011 Pearson Education, Inc. Screening Guidelines for the Early Detection of Cancer in Average-Risk Asymptomatic People Copyright © 2011 Pearson Education, Inc. Facing Cancer Cancer Treatments • Surgery to remove tumor • Chemotherapy • Radiotherapy • Researching genes and cell mutations • Immunotherapy • Cancer-fighting vaccines • Stem cell research Copyright © 2011 Pearson Education, Inc. ABC News Video: Treating Cancer with Bone Drugs | Treating Cancer with Bone Drugs Discussion Questions 1. Why do treatments such as this seem to focus on earlystage cancers? 2. Would you take a drug developed for a different health issue to help control the spread of cancer? How might taking a drug affect the rest of your body? 3. What questions should you ask your health care provider before taking medication? 4. Under what circumstances would you join a medical research study? Copyright © 2011 Pearson Education, Inc.