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PREVENTION MODELS OF OBESITY AND CARDIOVASCULAR DISEASES CONGRESS INFORMATION CONTENTS „ . . . . . . . . . . . . . . . . . . . . . . . . . . 3 COMMITTEES & ORGANISATION . . . . . . . . . . . . . . . . . 4 PROGRAM AT A GLANCE. . . . . . . . . . . . . . . . . . . . . . 5 SCHEDULE / DAY 1. . . . . . . . . . . . . . . . . . . . . . . . 6-7 SCHEDULE / DAY 2. . . . . . . . . . . . . . . . . . . . . . . . 8-9 LOCATION. . . . . . . . . . . . . . . . . . . . . . . . . 10-11 FLOOR PLAN. . . . . . . . . . . . . . . . . . . . . . . . . . . 12 REGISTRATION & CREDITS. . . . . . . . . . . . . . . . . . . . 13 GUIDELINES SPEAKER / POSTER PRESENTER . . . . . . . . . . 14 SOCIAL NETWORKING. . . . . . . . . . . . . . . . . . . . . . 15 WELCOME TO VIENNA. . . . . . . . . . . . . . . . . . . 16-17 SPONSORS. . . . . . . . . . . . . . . . . . . . . . . . . 18-19 ORAL PRESENTATIONS / INVITED ABSTRACTS. . . . . . . 20-37 POSTER PRESENTATIONS / SUBMITTED ABSTRACTS . . . 38-60 NOTES. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61 AUTHOR INDEX . . . . . . . . . . . . . . . . . . . . . . . . . 62 KEYWORD INDEX . . . . . . . . . . . . . . . . . . . . . . . . 63 INTRODUCTION OBESITY AND CARDIOVASCULAR DISEASES ARE THE MAIN CAUSES OF PREMATURE DEATH IN WESTERN COUNTRIES. WWW.POC-VIENNA-2016.EU The WHO declared obesity – especially in children and adolescents – as the most challenging health problem of the 21th century. Recent data from more than 19 million participants indicate that if the post 2000 trends continue – by 2025 global obesity prevalence will reach 17% in men and 21% in women. As an answer, the WHO and the EU claimed to implement effective measures to halt the rise of the epidemy of obesity and consequent diseases. Several projects in various countries are the one way, however there is no program which could be an example for large-scale successful programs in order to counter act the global obesity challenge. Concomitant with obesity, cardiovascular diseases are the main cause for early disabilities and death better understood and can be much more easier prevented – mostly through drug therapy. We will bring experts in that field together and really hope that new models and regimes for early and sucessful prevention models will be presented and discussed. Vienna presents itself as a modern city with high tradition and offers many attractions from arts, music and science. The congress team will be happy to welcome you in Vienna and will support you in any aspect to make your visit unique. Univ.-Prof. Dr. Kurt Widhalm LEGAL NOTICE Publisher: Vienna Medical Academy, Alser Strasse 4, 1090 Vienna, Austria. Layout: strg.design – Bernhard Stranz. Photos: Fotolia. All informations have been compiled carefully. Nevertheless, no guarantee can be given for the correctness. 2 3 COMMITTEES & ORGANISATION PROGRAM AT A GLANCE FRIDAY, 11TH NOVEMBER, 9:00 H CONGRESS COMMITTEE CO-ORGANISER ORGANISING OFFICE, B. Ludvik, Vienna Österreichischer Herzfonds SPONSORING & EXHIBITION J. Simon, Vienna EAROC MANAGEMENT 09:00-10:30 h SESSION 1 S. Ring-Dimitriou, Salzburg Beta-Judo Project Vienna Medical Academy 10:30-11:00 h THE ROLE OF HEALTH POLICIES IN O. Pachinger, Innsbruck PMU Salzburg Mrs. Susanne Pacher G. Hanauer, Vienna DAG – Deutsche Adipositas Alser Strasse 4, 1090 Vienna Gesellschaft / German Obesity Tel.: +43 1 405 13 83-25 11:00-12:00 h SESSION 2 SCIENTIFIC COMMITTEE Society Fax: +43 1 405 13 83 925 12:00-13:00 h G. Kostner, Graz Österreichische Ärztekammer [email protected] HOW TO BROADEN OUR KNOWLEDGE ON OBESITY IN THE PUBLIC HEALTH SETTING? H. Dieplinger, Innsbruck FHchol Austria COMBATING THE OBESITY EPIDEMIC ABSTRACT MANAGEMENT 13:00-14:20 h SESSION 3 D. Weghuber, Salzburg SECRETARY GENERAL POC Vienna 2016 c/o 14:20-14:50 h A. Pietrobelli, Verona Christina Pöppelmeyer, MSc Vienna Medical Academy THE THEORY BEHIND SUCCESSFUL PREVENTION OF OBESITY H. Hauner, Munich Oliver Helk, MD Mr. Manfred Vodrazka S. Bühler, Leipzig Alser Strasse 4, 1090 Vienna C. Stefanutti, Rome I. Lissau, Copenhagen SECRETARY Tel.: +43 1 405 13 83-13 Nina Nagy, MSc Fax: +43 1 407 82 74 Karin Gatternig, MSc [email protected] 14:50-17:45 h SESSION 4 EXAMPLES OF SUCCESSFUL PROJECTS IN EUROPE 19:30 h SOCIAL NETWORKING HEURIGEN EVENING SATURDAY, 12TH NOVEMBER, 9:00 H 09:00-10:45 h SESSION 5 10:45-11:00 h NATIONAL ACTIVITIES: REPORTS FROM VARIOUS COUNTRIES 12:30-13:15 h 13:15-14:15 h SESSION 6 14:15-14:40 h LOOKING BEYOND OBESITY: CVD PREVENTION IN HIGH RISK PATIENTS 14:40-16:30 h SESSION 7 HEREDITARY LIPID- AND LIPOPROTEIN DISORDERS 4 5 SCHEDULE / DAY 1 FRIDAY, 11TH NOVEMBER, 9:00 H INTRODUCTION / OPENING REMARKS K. WIDHALM 09:00-09:10 SESSION 4 SESSION 1 SESSION 2 THE ROLE OF HEALTH POLICIES IN COMBATING THE OBESITY EPIDEMIC CHAIR: K. WIDHALM / J.M. BORYS HOW TO BROADEN OUR KNOWLEDGE ON OBESITY IN THE PUBLIC HEALTH SETTING? CHAIR: S. BLÜHER / J. SIMON EXAMPLES OF SUCCESSFUL PROJECTS IN EUROPE CHAIR: L. MORENO / S. RING-DIMITRIOU Statement of the Austrian Government Obesity in Europe - epidemiology and inequality EPODE Method – From History to Best Practice (FR) 1.1. S. Karmasin, Austrian Federal Ministry 2.1. T. Lobstein, London 4.1. J.M. Borys of Families and Youth, Vienna 11:00 - 11:20 FURGASSL-HUBER WEINGUT & BUSCHENSCHANK Neustift am Walde 68, 1190 Vienna 19:30 14:50 - 15:10 09:10-9:20 Health Enhancing Physical Activity in Pre-school VIASANO, experiences from a long lasting community The position of the Austrian Social Security Institutions and School-aged Children in Europe based obesity prevention model (BE) 1.2. U. Rabmer-Koller, Vienna 2.2. H. Tschan, Vienna 09:20 - 9:30 11:20 - 11:40 The position of the Austrian Chamber of Physicians Psychological aspects 1.3. K. Forstner, Salzburg 2.3. P. Warschburger, Potsdam 11:40 - 12:00 Lunch Break 12:00 - 13:00 09:30 - 9:40 4.2. M. Roillet 15:10 - 15:30 Promoting Physical Activity in Italy to prevent Obesity – The EUROBIS Program (IT) 4.3. P. Defeo A food systems approach to obesity prevention 1.4. N. Pushkarev, EPHA, Brussels NETWORKING EVENT HEURIGEN EVENING 9:40 - 09:50 15:30 - 15:50 SALTO A Setting Approach – Kindergarten as Core Unit of Community Based Intervention (AT) Video statement SESSION 3 4.4. S. Ring-Dimitriou 1.5. V. Andriukaitis, Commissioner for Lessons learned from EPODE (WUV, EIN, NL) health and food safety, Brussels 09:50 - 10:00 THE THEORY BEHIND SUCCESSFUL PREVENTION OF OBESITY CHAIR: T. LOBSTEIN / I. LISSAU Open question-round 10:00 - 10:30 Principles of prevention of obesity: what works? Coffee break 10:30 - 11:00 3.1. S. Blüher, Leipzig 4.5. T. Visscher 13:00 - 13:20 15:50 - 16:10 16:10 - 16:30 Healthy nutrition as a challenge (AT) 4.6. J. Benedics 16:30 - 16:45 Economic aspects of prevention 3.2. J. Simon, Vienna 13:20 - 13:40 Strategic Use of Technology in Obesity Prevention 4.7. PANEL DISSUSSIONS CHAIR: D. WEGHUBER / H. TSCHAN PARTICIPANTS: M. SCHÄTZER (SALZBURG), H. HERZOG (VIENNA) 3.3. M. Jones Bell / K. Waldherr, Stanford 13:40 - 14:00 What future steps need to be taken Nutrition and Lifestyle Regimen for Infants 3.4. D. Weghuber, Salzburg 14:00 - 14:20 Coffee Break (Poster Viewing) 14:20 - 14:50 to achieve our goals in prevention? 16:45 - 17:45 The organisers cannot assume any liability for changes in the program due to external or unforeseen circumstances. 6 7 SCHEDULE / DAY 2 SATURDAY, 12TH NOVEMBER, 9:00 H SESSION 5 SESSION 6 SESSION 7 NATIONAL ACTIVITIES: REPORTS FROM VARIOUS COUNTRIES CHAIR: P. WARSCHBURGER / C.E. FLODMARK LOOKING BEYOND OBESITY: CVD PREVENTION IN HIGH RISK PATIENTS CHAIR: H. DIEPLINGER / H. HAUNER HEREDITARY LIPID- AND LIPOPROTEIN DISORDERS CHAIR: C. STEFANUTTI / T. STULNIG National Activity: Report from Italy Epidemiological data of cardiovascular diseases New aspects of familial hypercholesterolemia (FH) 5.1. A. Pietrobelli / L. Pecoraro, Verona, Italy 09:00 - 09:15 6.1. H. Dieplinger, Innsbruck in the youth National Activity: Report from Greece Prevention of cardiovascular diseases 13:15 - 13:35 7.1. K. Widhalm, Vienna 5.2. G. Chrousos, Athens, Greece 09:15 - 09:30 6.2. O. Pachinger, Innsbruck 13:35 - 13:55 14:40 - 15:00 The role of Nutrition in the treatment of familial hypercholesterolemia 7.2. H. Hauner, Munich Obesity in Denmark and actions to prevent obesity The PEP Family Heart Study 5.3. I. Lissau, Copenhagen, Denmark 6.3. P. Schwandt, Munich 13:55 - 14:15 Coffee break 14:15 - 14:40 09:30 - 09:45 15:00 - 15:20 Lipid lowering drugs and Lipoprotein Apheresis National Activities: Report from Spain 5.4. L. Moreno, Zaragoza, Spain 7.3. C. Stefanutti, Rome 15:20 - 15:40 09:45 - 10:00 New Drugs: Mechanisms of actions The role of lifestyle Intervention for treating 7.4. G. Kostner, Graz 15:40 - 16:00 obesity in children and adolescents 5.5. L. Grillich, Krems, Austria 10:00 - 10:15 Patient Organizations and the Medical & Science Community: A Perfect Team EDDY: a Viennese approach to school-based 7.5a. G. Hanauer-Mader, Vienna 16:00 - 16:20 prevention of obesity 5.6. O. Helk, Vienna, Austria 10:15 - 10:30 Making the difference: The important role of FH patient organizations 7.5b. J. Payne, Maidenhead National Activity: Report from Sweden 5.7. C. E. Flodmark, Malmö, Sweden 10:30 - 10:45 Coffee break 10:45 - 11:00 16:00 - 16:20 Closing remarks 7.6. T. Stulnig, Vienna 16:20 - 16:30 PANEL DISSUSSION CHAIR: P. SCHWANDT / O. PACHINGER What is the ideal age for prevention programs? How to include parents, what should not be done? 8 11:00 - 11:45 GUIDED POSTER SESSION CHAIR: D. EHRINGER-SCHETITSKA 11:45 - 12:30 Lunch Break 12:30 - 13:15 The organisers cannot assume any liability for changes in the program due to external or unforeseen circumstances. 9 LOCATION 0 500 M Das Billrothhaus der Gesellschaft der Ärzte in Wien – College of Physicians in Vienna 43 • 44 The Billrothhaus is the headquarter of the Gesellschaft der Ärzte in Wien (College of Physicians in Vienna). It was named after Theodor Billroth, an Austrian physician and former president of the society, Theodor Billroth. 44 www.billrothhaus.at 5 5 Frankgasse 8, 1090 Vienna, Austria 2 2 Underground: U2 station „Rathaus“ or „Schottentor“ 2 2 Tram: Line 43/44 (Universitätsstraße) 2•5 Car Parking: Otto Wagnerplatz Tiefgarage, Otto-Wagner-Platz, 1090 Vienna 0 POC [ Lecture room ] 500 M 2 0 1 6 2 46 5 P 43 • 44 44 46 43 • 44 46 5 5 5 2 10 2 2 2 5 11 FLOOR PLAN REGISTRATION Poster, Press conference What is covered by the registration fee? Registration Desk opening hours • Admission to all scientific sessions, exhibition and networking event1 • Program and congress bag • Coffee during breaks and light lunch Friday, 11th November 2016, Wardrobe 08:30-18:00 h Saturday, 12th November 2016, 08:30-15:00 h Certificate of Attendance Confirmation of attendance will be issued at the registration desk. Registration Please note that advance registration is mandatory in order to receive a ticket for the networking event. The tickets will be handed out at the registration desk. Limited attendance (first-come, first-served)! Tickets will be checked at the entrance. Please note that there will be strictly no access without the ticket. Payment received before 15.09.2016 (reduced rate) Payment received from 16.09.2016 (regular rate) Participants € 350 € 400 Abstract submitters € 300 € 300 Students €0 € 100 1 Break out room Lecture room Catering & Exhibition PARTERRE FIRST FLOOR CREDITS POC Vienna 2016 was granted 12 European CME Credits (ECMEC) by the European Accreditation Council for Continuing Medical Education (EACCME), Institution of the UEMS. The number of credits will figure on the respective confirmation, which will be handed out at the registration. The rules of the EACCME state that participants are kindly asked to fill in the feedback (evaluation) form included in the conference bag. It has to be returned to the registration desk. 12 Participation in the scientific sessions of the “International Symposium: Prevention models of obesity and cardiovascular diseases” is recognized within the Postgraduate Education Programme of the Austrian Medical Chamber with 9 credits. Free WIFI access will be available on site User: bhwireless Password: bill22bill333 13 GUIDELINES SPEAKER – POSTER PRESENTER Projection and Technical Setting The lecture room will be equipped with a data projector. All major kinds of Power Point and PDF‘s are accepted. You are also welcomed to use your own laptop or Mac. Please bring your data on a USB-stick It is essential that you deliver your presentation at the technician‘s desk in the lecture room preferably in the morning of the day your talk is scheduled, but not later than during the coffee break preceding your session. Poster Format The usable size of the poster board is 90 cm width x 130 cm height (approx. 35,4 x 51,2 inches) and posters should be in upright format. Adhesive material will be made available. SOCIAL NETWORKING Poster schedule for display, mounting and removal Your poster will be on display throughout the conference days. Your presence and availability for discussions at the poster is requested on Friday, 11th November from 14:20 h to 14:50 h (Poster Viewing during the Coffee Break) and on Saturday, 12th November from 11:45 h to 12:30 h (Guided Poster Session). • Posters will be on display from Friday, 11th November (9:00 h) to Saturday, 12th November (14:40 h). • Poster mounting will be possible on Friday, 11th November from 8:30 h to 9:00 h • Removal will be possible on Saturday, 12th November from 14:40 h to 17:00 h strict! Access before and after this time is not possible! Please note that posters not removed until then, will be taken down by the staff of the conference centre and will not be stored or sent to the authors after the meeting. HEURIGEN EVENING FRIDAY, 11TH NOVEMBER, 19:30 H Furgassl-Huber / Weingut & Buschenschank Neustift am Walde 68, 1190 Vienna Tel. +43 (0)1 440 14 05 E-Mail: [email protected] Bus: Line 35A 14 Should you have any questions, our congress staff will be pleased to help you. Please contact the registration desk. Please note that advance registration is mandatory in order to receive a ticket for the networking event. The tickets will be handed out at the registration desk. Limited attendance (first-come, first-served)! Tickets will be checked at the entrance. Please note that there will be strictly no access without the ticket. 15 WELCOME TO VIENNA The feeling of wellbeing enjoyed by locals and tourists has been confirmed repeatedly by leading international studies and city rankings. Vienna is a dream city for anyone with an interest in history. Narrow medieval alleyways and grand boulevards lead to historic sights such as the Imperial Palace (Hofburg), Belvedere Palace, Burgtheater, the Spanish Riding School, St. Stephen’s Cathedral, the Opera House, Karlskirche, or Schönbrunn Palace. In 2001, the city centre was designated a UNESCO World Heritage Site. TOURIST INFO Tourist-Info Vienna Albertinaplatz/Maysedergasse, 1010 Vienna Daily from 9.00 am - 7.00 pm Tourist-Info Vienna Airport in the arrival hall Daily from 7.00 am - 10.00 pm Tourist-Info Main Station Vienna has been synonymous with music for centuries, and was home to Mozart, Beethoven, Schubert and Johann Strauss. The Vienna Philharmonic Orchestra is one of the world‘s top orchestras and the Vienna Boys’ Choir is triumphantly successful wherever it tours. Vienna possesses a lively and vast array of cultural attractions from classical or experimental theatre, film or dance festivals, opera or operetta, as well as exhibitions and concerts. The Museum of Fine Arts is one of the world‘s largest and most distinguished museums housing priceless works of art. Art accompanies you wherever you go in Vienna – even some of its underground stations are listed properties because of their elegant ornamental Jugendstil (Art Nouveau) style designed by Otto Wagner. at the InfoPoint of ÖBB Daily from 9.00 am - 7.00 pm Wien Hotels & Info Tel. +43-1-24 555 Fax +43-1-24 555-666 Monday - Saturday, 9.00 am - 7.00 pm E-Mail: [email protected] Web: www.wien.info/en „ Vienna has 1,7 million inhabitants and is situated on the banks of the Danube. Austria’s capital ranks on top of the most attractive cities world wide. 16 17 SPONSORS SHOWCOOKING Side Event on Monday, 14th November 2016. This event takes place without spectators. as per 28th October 2016 18 19 ORAL PRESENTATIONS – INVITED ABSTRACTS 1.4. A FOOD SYSTEMS APPROACH TO OBESITY PREVENTION N. Pushkarev [email protected] European Public Health Alliance (EPHA), Brussels, Belgium 1.2. THE POSITION OF THE AUSTRIAN SOCIAL SECURITY INSTITUTIONS U. Rabmer-Koller [email protected] Federation of Austrian Social Security Institutions, Vienna, Austria The unsettling truth is that 30 years since the start as it allows to join-up with other strong pressures to of the rise of obesity no country has demonstrably achieve a transition in the food system, but also from contained or reversed this epidemic. Obesity is now a realisation that many of the pressing concerns are identified as a main global risk, on par with terrorism. interrelated. The new EAT-Lancet Commission on the Prevention of obesity and cardiovascular diseases is, factors for cardiovascular diseases and obesity: - Last The preventive approaches tried so far have not deli- food system for instance recognises that “Expanding due to prevalence and incidence of these widespread summer we initiated a national exercise programme vered at a sufficiently large scale. This can in part be waistlines are a problem not just for dietitians and diseases, a major field of action for the social insuran- in public space in cooperation with the ministry of attributed to a ‘cycle of inertia’ in public policy-making population health specialists but, increasingly, for ce institutions in Austria. As a strategic framework we sport and the major sport federations in Austria. More and strong pressure from interest groups not to de- Earth system scientists too.” formulated 10 health targets together with the major than 120 weekly movement classes have being offe- part substantially form the status quo. All this despite stakeholders in Austria. As health of the population is red to the general public at no charge. - The sickness a string of sensible public health recommendations to Topics explored during the session: Why agricultural determined by living conditions and lifestyles, which funds offer nutirition councelling to the Austrian peo- experiment with policies for creating healthy food and policy needs to be part of the obesity prevention di- are influenced by many sectors and not by the health ple. - A health promotion programme for pregnant drink environments. The hypothesis pursued by EPHA scussion. sector alone, Austria decided that these health targets and breastfeeding women and children up to 3 years is that framing obesity and other diet-related disea- should be based on a “health in all policies view”. They of age (Healthy eating from the start!). - Smoking ad- ses within a food systems context may be a promising How unhealthy diets, climate change and antimicrobi- provide a framework for coordinated action including diction counselling is widely available in Austria. Most strategy. A food systems approach relates all the food al resistance have common roots. a binding implementation plan, which is backed by all oft the social security institutions provide smoking system activities (growing, harvesting, processing, Why public health needs to take account of the struc- institutions, by all ministries involved. We also support addiction counselling in an individual or group setting packaging, transporting, marketing, consuming, and ture of food supply chains. the population at different points of life and settings according to the quality standards of the social securi- disposing of food and food-related items) to the out- to prevent and target the common risk factors of obe- ty. The Austrian smoking quitline, which celebrated its comes of these activities for dietary health (incl. obe- One of the conclusions is that a ‘food policy’ frame- sity and cardiovascular diseases. Different strategies 10-year anniversary this year, with more than 3.500 sity and cardiovascular health), socio-economic issues work is needed to properly conceptualise these inter- reach from health promoting pre-birth interventions Smoker counselling each month. - More than 1.300 and the environment (UNEP). This reframing may not linked challenges and propose solutions that maximi- within the family, health promoting schools and work- companies received a seal of approval for its company only be helpful for reasons of political expedience, se co-benefits while minimising trade-offs. places to the annual medical check ups. Just to men- health promotion efforts. tion a few of initiative concerning the common risk 20 21 2.1. OBESITY IN EUROPE - EPIDEMIOLOGY AND INEQUALITY 2.3. PSYCHOLOGICAL ASPECTS T. Lobstein1,2 [email protected] 1 World Obesity Federation, London, United Kingdom, 2Public Health Advocacy Institute of Western Australia, Perth, Australia P. Warschburger [email protected] University of Potsdam; Department of Psychology; Counselling Psychology, Potsdam, Germany The presentation will consider recent trends in child in obesity remain very significant between income Obesity is not only a medical/nutritional problem ty like increased anxiety or depression. In addition, and adult obesity prevalence in Europe, and consider groups in most EU member states. There is also evi- but also a psychological one. In the literature two a negative body-image, a lower self-esteem and some of the causes of the variations in obesity pre- dence of health differences between member states main facets are considered: the role of psychological disordered eating behaviors are common problems valence, and highlighting some of the consequen- ranked according to their degree of social inequality: factors in the etiology of obesity and the psychological among obese children and adolescents. Compared ces. Recent trends show a continuing rise in obesity countries with higher social inequality have higher consequences of being obese. Although obesity is not to normal-weight peers obese children and adole- in the region for both children and adults, and the- levels of ill health generally and a greater prevalen- regarded as a mental disorder there is growing evi- scents report a lower health-related quality of life. re are significant consequences in terms of ill-health ce of obesity in adults and in children. National and dence that psychological issues play an important role Especially children who internalize the weight-bias in childhood as well as adulthood. In some member regional policies to tackle obesity will need to include in the multifactorial etiology of obesity. Psychological are at increased risk for increased psychopathology states there has been an easing of the rise in obesi- universal as well as targeted interventions so that all theories emphasize for instance the role of emotional and impaired quality of life. Taken together psycho- ty prevalence in childhood in recent years, and this is the population can benefit, and especially those that eating as coping strategy in response to stress, sad- logical issues play a prominent role in obesity. In my more clearly seen in children living in wealthier neigh- need it most. ness or just out of boredom. Recent studies illustrated talk, I will mainly focus on the negative psychological that an increased impulsivity or deficits in self-regula- consequences of obesity for children and adolescents tion strategies may play a role in the development of and illustrate how these psychological issues may obesity. On the other side there is consistent evidence serve not only as consequences of obesity but also as a that obesity is associated with increased mental cause for the emergence and maintenance of obesity. health risk as a sequelae. In our society being over- Therefore, prevention and treatment approaches weight or obese is viewed very negatively and obese in that field should address these issues in order persons are at a greater risk to experience weight- to ensure a comprehensive care for children and related teasing or being bullied by others. These adolescents and their families and to break this experiences may lead to psychological comorbidi- vicious circle. bourhoods and better-educated families. Inequalities 2.2. HEALTH ENHANCING PHYSICAL ACTIVITY IN PRE-SCHOOL AND SCHOOL-AGED CHILDREN IN EUROPE H. Tschan [email protected] Dept. Training and Movement Science, University of Vienna; Centre of Sport Science and University Sports, Vienna, Austria There is conclusive evidence that the physical fitness preventing inactivity, overweight and obesity. The and health status of children and youth are substan- current presentation aims to give an overview about tially enhanced by frequent moderate and vigorous the level of physical activity and exercise among pre- physical activity. Compared to sedentary young peo- school and school-aged youth in Europe, based on ple, physically active children and youth have higher major studies measuring physical activity. Additio- levels of cardiorespiratory fitness, muscular endu- nally age- and sex specific characteristics, as well as rance and muscular strength, and well-documented effects of a low socio-economic status and migration health benefits include reduced body fat, more on health enhancing physical activity are highlighted. favorable cardiovascular and metabolic disease risk Furthermore, these review attempts to give an over- profiles, and enhanced bone health. It is therefore view about physical interventions performed and a concern that only 1 in 5 children in the European their outcomes on overweight and obesity, respecti- Union reports taking part in regular (60 minutes vely. Finally the different forms of sport participation or more) moderate-to-vigorous intensity exercise. (formal versus informal versus non-formal) and their Combined with the rising prevalence of obesity the different roles as health promotion strategies to increasing level of sedentary behavior has resulted increase physical activity in childhood are discussed. in childhood being seen as an important period for 22 23 3.2. ECONOMIC ASPECTS OF PREVENTION 3.4. NUTRITION AND LIFESTYLE REGIMEN FOR INFANTS J. Simon [email protected] Centre for Public Health, Department of Health Economics, Medical University of Vienna, Vienna, Austria D. Weghuber [email protected] Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria The talk will use Geoffrey Rose’s prevention para- the development of guidelines for statin usage in the The prevalence of childhood overweight and obesity life, when biological determinants of later obesity risk, digm as theoretical framework and examine it from UK based on evolving cost-effectiveness evidence has risen substantially worldwide in less than one ge- feeding behaviour and dietary preferences are the viewpoint of health economics. The value of the from the Heart Protection Study. Furthermore, latest neration, a trend that is already seen in early child- shaped. Some lifestyle and nutrition interventions in “high-risk” strategy of prevention will be compared to evidence on the costs and benefits of primary and hood. It has been shown that rapid weight gain during infancy have been shown to reduce subsequent obe- those of the “population strategy” option supported secondary prevention options for obesity will be infancy is associated with an increased risk of obesity sity risk. From the infant perspective, breastfeeding with relevant examples. Examples to scrutinize the presented together with the relevant economic and weight gain during the first 24 months of life is decreases the odds of childhood overweight. The use presented theoretical framework will be sought from evaluation methods and their limitations. the best overall predictor of later obesity. The broad of lower-protein formulas and a reduction of dairy range of factors impacting on obesity require a mul- protein intake during complementary feeding has tifaceted approach on both a societal and individual been suggested to be of protective value, although level to halt the rise of the obesity epidemic. The Euro- data are limited. There seems to be no protective pean Action Plan on Childhood Obesity has identified effect of later introduction of solid foods while early eight key areas that warrant particular attention, one introduction (before 17 weeks of age), shorter breast- of which is the need to support a healthy start into feeding duration, higher energy intake, shorter sleep life. Progress has been made in the identification of duration, high maternal control over feeding, are causative factors and preventive measures in early associated with the risk of childhood obesity. the field of cardiovascular disease prevention using 3.3. STRATEGIC USE OF TECHNOLOGY IN OBESITY PREVENTION M. Jones Bell1,2,3 [email protected] 1 Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States, 2Lantern, San Francisco, CA, United States, 3 ICare, Medical University of Vienna, Vienna, Austria The essence of prevention is to cease a health prob- implementation and maintenance of obesity preven- lem before it begins, or at the least, to stop disease tion interventions. This talk describes how to stra- progression. The very nature of this involves reaching tegically employ technology through the lens of the and engaging individuals who may not yet be expe- RE-AIM framework in order to support the develop- riencing negative consequences of a health problem. ment, evaluation and implementation of health pro- This is a well-known challenge in obesity prevention motion and prevention programs under real-world in which evidence-based strategies require lifestyle conditions. A program of research developing and changes by individuals, and often their families, who evaluating StayingFit, an online obesity prevention may not perceive a need for such changes. Preventive intervention, conducted across several countries for interventions require clever strategies to enhance the last decade will be used as a case example. User- motivation and/or modify behavior. Technology is not centered design principles and industry best practices a solution in and of itself but when used strategically will also be provided to illustrate key points. it can facilitate reach, efficacy/effectiveness, adoption, 24 25 4.2. VIASANO, EXPERIENCES FROM A LONG LASTING COMMUNITY BASED OBESITY PREVENTION MODEL 4.4. SALTO: A SETTING APPROACH – KINDERGARTEN AS CORE UNIT OF COMMUNITY BASED INTERVENTION M. Roillet [email protected] VIASANO ASBL/VZW, Brussels, Belgium S. Ring-Dimitriou [email protected] Department of Sport Science & Kinesiology, Paris Lodron-University of Salzburg, Austria; Obesity Academy Austria Based on the EPODE methodology, VIASANO was development of the programme. What is the best In Austria 20% of boys and 18% of girls aged 4 to 6 macro-level the interpersonal level is the key layer for launched in Belgium in 2007. Its objective is to prevent status for CBPs? Initially exploited by Proteines Brus- years are overweight and obese (WHO assessment; SALTO actions, as kindergarten teachers and parents childhood obesity by changing the environment of sels, a health communication agency, VIASANO is now Mayer et al., 2014). This is in line with European data, (care givers) are identified as key drivers, because chil- families and facilitating healthy choices related to run by an NGO. What are the advantages of this new where a range of overweight and obesity of 12% in dren grow-up in the world of adults (Ring-Dimitriou et food and physical activity. Communities and their status? How to involve communities from 2 different Rumania to 32% in Spain was reported (Caroli & Vania, al., 2015). stakeholders operate the change, involving repre- cultures (the Flemish and the Walloon culture) and 2015). In our own SALTO sample (n=128 girls, n=135 Accordingly SALTO, Salzburg together against obe- sentatives of the administration services and local keep them motivated? How does VIASANO function boys) 14% and 3% of girls as well as 13% and 6% of sity, is an at least 3-years lasting initiative that focus actors such as schools, general practitioners, sports and how it has evolved over time? One of the pillars boys where overweight and obese, respectively. This on the competencies of care-givers to enable them to clubs, leisure centres, shopkeepers and retailers, as- of VIASANO is an ethical public-private partnership. means nearly every 5th child in the kindergarten is implement health enhancing actions in the daily life sociations, etc. The VIASANO programme is currently What are the strengths and weaknesses of such an affected by an unhealthy body mass, i.e. one to two of children. As a core setting in the community SALTO managed by an NGO. It operates in collaboration with economic model? And last but not least, what are the children in a kindergarten group. Because overweight encourages kindergarten teachers to get in contact an independent expert committee, receives funding challenges of evaluating such a programme? Mireil- or obesity strongly tracks into adolescence and adul- with other services like sport clubs or private capaci- from private partners and is supported by Belgian le Roillet, in charge of the daily management of the thood early prevention strategies are warranted! ties. SALTO relies on the EPODE method and is a mul- political institutions as well as scientific associations. programme from the very beginning will present the The kindergarten seems to be a promising core set- ti-method, multi-sectoral and multi-stakeholder pro- Since the very beginning 10 years ago, VIASANO has VIASANO story in detail and share learnings on the ting, as the attendance is obligatory for five to six year ject. Beside that, children, parents and kindergarten gained a lot of experience in the management and growth of the programme. old children and a second obligatory year (4 to 5y) is teachers will be investigated regarding physical activi- already discussed at ministry level in Austria (Haas et ty and eating preferences, physical fitness levels and al, 2012). Beside this, policies with a special focus on sociodemographic data. How we translate evidence health promotion in early childhood are introduced into practice and investigate practice-based evidence over the last years (e.g. Kindergesundheitsstrategie, in early childhood obesity prevention will be outlined National Action Plans on Nutrition and Physical Ac- in the presentation. tivity). Beside a favorable political framework on the 26 27 4.5. LESSONS LEARNED FROM EPODE T. L. S. Visscher1,2 [email protected] 1 Windesheim University of Applied Sciences, Zwolle, Netherlands, 2Epode International Network, Paris, France 4.7. “DRINKING AND SNACK LICENSE” – NATIONWIDE INITIATIVE TO IMPROVE THE NUTRITION-RELATED KNOWLEDGE AND DIETARY PATTERN M. Schätzer [email protected] SIPCAN - Initiative für ein gesundes Leben, Salzburg, Austria Whereas the childhood obesity epidemic is main- Dutch JOGG-approach a fifth pillar is added: linking ly caused by environmental determinants making prevention and management. The EPODE-approach Background: School projects that aim at improving as well as the nutritional knowledge was examined. the unhealthy option too easy, it is clear that divers has been shown to be effective and its impact is enor- eating and drinking patterns among schoolchildren 348 schoolchildren from Viennese schools partici- key-players in those environments have a role in de- mous, meaning that many families and professionals are effective in the fight against overweight and obe- pated in this study. The nutrition-related knowledge veloping healthy environments and thereby the pre- have become part of the EPODE movement. Further, sity. The scientific institute SIPCAN has developed questionnaire (20 nutrition-related questions), was vention of childhood obesity. The EPODE program is the EPODE Promotion of Health Equity program has nationwide initiatives in this field. An example of these assessed before and after the intervention. Principal an evidence-based and community-based approach been shown to be effective in reducing socio-econo- programs is the “Drinking and Snack License”. The component analysis (PCA) was used to identify the tackling childhood obesity. Key pillars of EPODE are mic health disparities. This lecture in Vienna will ad- main goal of this program is to emphasize the import- dietary patterns of 24 food groups. It revealed two political involvement, social marketing, public-priva- dress the different aspects of evidence and impact ance of a healthy diet and to motivate the students to dietary patterns: energy-dense and healthful. BMI was te partnership and monitoring and research. In the from perspectives of the child, parents and professi- inhabit a healthier nutritional behavior. calculated based on self-reports. Material & methods: The topics covered by the Results: 4% of all schoolchildren were obese and 15% “Drinking and Snack License” are in line with the overweight. At baseline the distribution regarding Austrian curriculum of 5th grade biology classes and energy-dense and healthy eating patterns was ba- the European curriculum for nutritional education lanced between the intervention group (n=233; 49% of children that are between 8 and 13 years old. The vs 51%) and the control group (n=115; 55% vs. 45%). project lasts for five weeks. Every week there is one After adjusting for age, sex, and initial nutrition-rela- unit addressing certain topics that the teacher will ted knowledge, the intervention group showed a 1.8 work on with the students during one lesson. In addi- times greater adherence to healthful dietary pattern tion to the lessons the students observe their eating [OR = 1.81 (95% CI 1.03, 3.2); p=0.039), compared to and drinking habits with the help of a “snack journal”. the control group. The intervention group showed a During the program the parents receive weekly infor- significant increase in nutrition-related knowledge mation about the contents covered in class and are [7.7 (7.3-8.0) vs. 9.3 (8.5-9.2) points; p<0.001]. onals in the families’ environments. motivated to support their children. After completing the 5th unit the students take part in a theoretical Conclusion: This analysis showed that the “Drinking and a practical exam and if they pass they receive a and Snack License” can significantly improve the “Drinking and Snack License”. nutrition-related knowledge. After the intervention, children had a greater adherence to healthful dietary 28 Evaluation: The effectiveness of the program has pattern. Multiplication: In the school year 2016/17 been tested in a controlled intervention study in more than 11.000 students from all regions of Austria which the impact on the eating and drinking behavior take part in the “Drinking and Snack License” 29 30 5.1. NATIONAL ACTIVITY: REPORT FROM ITALY 5.3. OBESITY IN DENMARK AND ACTIONS TO PREVENT OBESITY A. Pietrobelli1,2, L. Pecoraro1 [email protected] 1 Pediatric Unit, Verona University Medical School, Verona, Italy, 2 Pennington Biomedical Research Center, Baton Rouge, Los Angeles, CA, United States I. Lissau1,2 [email protected] 1 Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark, 2 Child Obesity Unit, Department of Child Health, University Hospital Skane, Malmö, Sweden Italy is at the top level in term of pediatric obesity ring conception period and pregnancy. furthermore, Among children born in 2008, 9.3% were overweight inspired by the Swedish Bunkeflo model. Two main incidence/frequency. Recently the Italian Statistic Data overweight/obese women who plan to be pregnant and were 2.5% obese, whereas in for children born differences remain between the Swedish and Danish Center (ISTAT), reported that 24% of the subjects bet- should reduce weight before conception. 2. Before and in 2000, 14.1% were overweight and were 3.8 % obe- school systems. In Sweden, children are served lunch ween 6 to 17 years of age are overweight, with higher during pregnancy, at birth and during early life, body se at their latest measurement at school. Regional every day, while Danish children bring lunch from percentage in the South of Italy. The same report un- composition measurements are crucial to monitor differences occur with the lowest rates in the capital home or buy at school if available. Additionally, Da- derlined that one million of subjects between 6 to 11 growth. 3. The exclusive breastfeeding is recommen- region and the highest rates in the neighboring regi- nish children perform 45 minutes of physical activity years of age are overweight or obese. It is well known ded at the beginning of life until six months. 4. Four on, namely the region of Zealand. These figures have on a daily basis. Currently, some trials are taking place that 30% to 60% of overweight or obese children will be to six months of age is the optimal window to intro- been relatively stable the past four years (Sundheds- with the goal of preventing child obesity. However, a overweight or obese in adult age. According with ISTAT duce complementary feeding. Until one year of age, datastyrelsen 2016). A review from 2006 initiated by major issue is that most projects are concerned with the excess weight has a result of 2,5 billion of euro breast milk or follow-on formula must remain the main the National Board of Health, shown that no Danish treatment of obesity rather than preventing children per year of cost. Several national projects are ongo- source of feeding and cow’s milk must be avoided. 5. studies used the school as an arena for preventing from overweight and obesity in the first place. Rese- ing: a. “Passi” study where information on prevalence Fruit and vegetables liking begins early. Daily variety, overweight and obesity among children (Lissau 2006). arch on smoking has demonstrated that structural ch- and frequency of obesity are presented together with diversity in a meal and repeated exposure up to eight However, starting August 2014, all children from the anges have a strong effect on decreasing number of suggestion on prevention; b. “Progetto Cuore” whe- time are efficient strategies to increase acceptance ages 6 to 15 (equivalent to grade 0 to 9) participate daily smokers - it now remains to be seen if 45 minu- re regular measurement of cardiac risk factors were of food not well accepted at first. There is no need to in 45 minutes of daily common physical activity in the tes of mandatory daily physical activity at school will collected together with treatment; c. Project HS-CSD add sugar or salt or sugary fluids to the diet. 6. Res- middle of the day. This initiative has obviously been affect the national rates of overweight and obesity. LPD reported prevalence and discussed possible pre- pect the child appetite and avoid coercive “clean your vention/treatment strategies; d. “Body Weight, Eating plate” feeding practices. Adapt portion of food and Patterns, and Physical Activity: the Role of Education”: not to use food as reward for good behavior. 7. Limit a long term project with analyses of life style and pe- animal protein intake in early life to reduce the risk of culiar suggestions on balanced diet and regular phy- an early adiposity rebound. Growing-up milk should sical activity among children and adolescents; e. “Gain be preferred to cow’s milk in order to limit intake and health: making healthy choices easier”, a national meet essential fatty acids and iron needs. 8. The intake project promoting fruit and vegetables together with of adequate fat containing essential fatty acid should Spain, as the other Mediterranean countries, has a on “Nutrition, Physical Activity and Obesity” (NAOS) regular physical activity; f. Health Behavior in School- be promoted. 9. Parents have a model role in feeding, high prevalence of overweight and obesity in child- and equivalent strategies in all the Spanish regions. aged Children (HBSC), in conjunction with World Health with TV and other screens turned of during meals. ren. The last survey, conducted in 2013, in a nationally However, little economic investment has been alloca- Organization, targeted adolescents, promoting infor- 10. Preventive interventions consisting in promoting representative sample of 3.426 children aged 7-8 ye- ted to such initiatives. The main contribution has been mation on healthy diet and healthy life style. Another physical activity and child has to get sleep sufficient- ars, showed a prevalence of overweight of 23.2% and the development of two surveys in the framework of interesting project coming from the Mediterranean ly. In fact, a short sleep duration may be associated obesity of 10.5%, using the IOTF standards. This study COSI (2011 and 2013) and more recently the National Nutrition Group (MeNu Group) a working group of with increased risk of developing obesity. The Italian was performed within the COSI (Childhood Obesity Nutrition Surveyof children and adolescents (ENALIA, researchers from the Mediterranean region willing to Minister of Health recently presented a “policy maker” Surveillance Initiative) Initiative. These results, com- Encuesta Nacional de Alimentación en la población in- contribute through their research or medical activities where is mandatory a commercial spot control, taxes pared with previous surveys seem to show a slight fantil y Adolescente) that will provide information of to the prevention of pediatric obesity. This group ela- on soft drinks, clear information on the labels, together decrease in the observed prevalences. In terms of dietary intake in children from 6 months until 17 ye- borated a proposal of 10 good practices to help pre- with support of promotion of healthy diet and regular research, there are intervention studies that have ars. In summary, there are some activities that should vent obesity in the first 1,000 days. 1. Both mother and physical activity. Given the suggestion described in this been performed in the recent years, such as IDEFICS contribute to tackle the childhood obesity epidemic in father behavior matter. A balanced diet with adapted presentation, concerted public health efforts are nee- or ToyBox, both funded by the European Comission. Spain. excessive fat and protein intake and favoring fruits ded to achieve the healthy objectives for obesity and In terms of public health, there is a National Strategy and vegetables is recommended for both parents du- nutrition and to fight the childhood obesity epidemic. 5.3. NATIONAL ACTIVITIES: REPORT FROM SPAIN L. A. Moreno [email protected] GENUD Research Group, Universidad de Zaragoza, Zaragoza, Spain 31 5.5. THE ROLE OF LIFESTYLE INTERVENTION FOR TREATING OBESITY IN CHILDREN AND ADOLESCENTS L. Grillich [email protected] Danube University Krems, Krems, Austria 5.6. EDDY: A VIENNESE APPROACH TO SCHOOL-BASED PREVENTION OF OBESITY K. Widhalm, O. Helk, C. Poeppelmeyer, O. Pachinger [email protected] Austrian Institue for Clinical Nutrition, Vienna, Austria Introduction: The prevalence of obesity, poor lifestyle Protocoling), sports- scientific (Acclerometry, testing Research Objective: To investigate lifestyle inter- baseline and follow-up assessments. At 10-12 months and related cardiovascular- and metabolic diseases is of physical capabilities), psychological (concentration vention effects of a structured 10-12-month exerci- significant favorable effects were observed in several on the rise in industrialized countries worldwide. Due tests, AD-EVA questionnaire) and medical (lipid- and se and nutrition program for overweight and obese outcome measures: For example a change in the to the fact that conventional treatment of obesity and vitamin profile, glucose, insulin), bioimpedance analy- schoolchildren aged 6 to 18 years. distribution of weight related groups (p<.00) (less unhealthy habits is difficult and often fruitless, pre- sis) assessments. obese and morbid obese but more overweight vention programs have gained importance in recent Study Design: Prospective uncontrolled before and children), less eating to cope with unpleasant emo- years. We present the results of the EDDY-pilot trial, Results and Discussion: Our standardized interventi- after study with assessments at baseline and 10-12 tional states and situations (children p<.00), higher in which we aimed to implement a standardized in- on was successfully implemented in the participating months. The targets of intervention were overweight satisfaction with their figure (children p<.00) and tervention in Viennese Schools and evaluate its practi- intervention schools. The control group showed a ten- and obese children between seven and 18 years who- better motor skills (children p<.00). Parents reported cability and efficiency. Methods: EDDY is cluster-ran- dency to have higher body fatpercentages and mean se BMI is above age and sex-specific cut-off points[1] higher ability to adhere to health promoting recom- domized, controlled pilot study. 4 schools in Vienna LDL at follow up when compared to baseline. This ef- and their parents. The intervention was implemented mendations (p≤.01) and lower preferences for snacks participated and were divided into intervention- and fect occurred in the intervention group on a reduced in cooperation with children and youth departments (parents p=.01). Parents and children showed a lower control group in a 2:2 ratio. A total of 146 adolescents scale, possibly reflecting the success of the interventi- of regional hospitals and consisted of 120 hours of wish for weight reduction (p=.02; p≤.01). No relevant aged 10 to 14 participated. A standardized interven- on. In regard to the QUICK-index values insulin sensi- exercise and nutrition training (60 hours for the chil- changes could be observed in the eating and exercise tion of a total of 25 lessons was implemented by ex- tivity has decreased in both intervention- and control dren and 60 hours for their parents) during 10-12 habits of children, or in most of their cardiovascular perts. The topics discussed in these lessons involved group. It is possible however that this is an effect of months. Main outcome measures included eating and risk factors. nutrition, physical activity and physiology. The success pubertal age. Further trials will be required to assess of the intervention was evaluated by nutritional-scien- the reproducibility of our findings in larger cohorts. exercise habits, well-being, cardiovascular risk factors (blood pressure, weight, body-mass index, serum li- Conclusions and Implications for Practice: pids, blood glucose), motor skills and preclinical and The lifestyle Intervention program had a positive clinical eating disorders. The statistical analysis was effect on relevant outcome measures at children done with t-test and Wilcoxon-Test (depending on (distribution of weight related groups) and positive the preconditions). The last-observation-carried-for- effects on parents. But there was no effect in cardio- ward method was used to minimize selection effects vascular risk factors and exercise habits and only caused by dropouts. a limited effect on eating habits of children. Due to tific (Food Frequency Questionnaires, Nutritional 5.7. NATIONAL ACTIVITIES: REPORT FROM SWEDEN C. E. Flodmark [email protected] Dept of Pediatrics, Skåne University Hospital in Malmö, Malmö, Sweden the fact, that it was not possible to create a control Population Studied: group the positive effect in motor skills could also be In Sweden preventive actions and health care is of the different growth charts have been under debate 157 children aged 6 to 18 years and their parents. attributable to aging. Therefore there is a recommen- major focus in the state financed health care system. as the national standard has difficulties in surviving dation for a critical revision of the program especially Besides research, child health care covers 98% of all when there is an increasing influence from software Principal Findings: At baseline the parents agreed the theoretical foundation and implementation of the children and school health care has a similar high co- developers from companies as the state has no de- to their children´s participation in the study. 117 measures to change eating and exercise habits. verage. In these health care organizations there are velopment in this area. Focus is also an e-health whe- children (mean age 11.45; 56% female, 45.5% [1] the 90 th. percentile for overweight and the 97 differences in how much resources is put into pre- re different solutions are under development. morbid obese, 38.6% obese; 14.5% overweight) and their th. percentile for obesity (Wiegand, 2005) vention of obesity. In research different behavioural parents (mean age 41; 86% female) completed the programs have been studied where motivational interviewing (MI) has been tested in several studies. The different studies give conflicting results. Furthermore 32 33 6.1. EPIDEMIOLOGICAL DATA OF CARDIOVASCULAR DISEASES 6.3. THE PEP FAMILY HEART STUDY H. Dieplinger [email protected] Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria P. Schwandt [email protected] Arteriosklerose-Präventions-Institut, Munich-Nuremberg, Germany Despite a significant decline within the last decades, industrialised countries) between men and women Background: The Framingham Heart Study was the more frequent in Iranian and Brazilian while the pre- cardiovascular disease (CVD) remains the leading cau- and among different socio-economic subpopula- first community-based study which demonstrated valence of hypertension was lowest in Iranian youth4. se of death among Europeans and around the world. tions. This overview provides a current update on the that the combination of traditional risk factors subs- Weight-related normative blood pressure percentiles An estimated third of all deaths worldwide were cau- burden of CVD, and in particular coronary heart tantially increased the risk of cardiovascular diseases for youth might deserve more debate5. Because chil- sed by CVD in 2010, more than all communicable, disease (CHD) and stroke, across the countries of (CVD) which was confirmed and extended by many in- dren may have more frequent contacts with the he- maternal, neonatal and nutritional disorders com- Europe and worldwide and will discuss key data terventional studies among adults and children. alth care system than their young parents we tested bined, and double the number of deaths caused by in relation to mortality and morbidity from CVD. A cancers. CVD prevalence and incidence data in Euro- particular emphasis will be placed on the importance of Purpose: Because family-based studies using lifestyle detected by screening their children6. In fact, this pro- pe and worldwide show that the burden of mortali- conventional and novel diagnostic markers (both ge- change are scarce we started the community-based cedure was an efficient case-finding strategy among ty continues to show large geographic inequalities netic and environmentally driven) for early detection and prospective Prevention Education Program (PEP) in 2720 child-parent pairs. In 852 biological families we among different countries. Furthermore, significant possible therapeutic intervention to fight CVD. the school year 1993/94. The PEP Family Heart Study1 evaluated the association of nutrition, leisure time is a 14 years’ follow-up study for assessment of CVD physical activity and smoking with seven conventio- risk factors and sustained lifestyle change among chil- nal CVD risk factors which were also significantly as- dren and parents. sociated between parents and children7. Daily ener- differences can also be obvserved (particularly in whether silent CVD risk factors in parents could be 6.2. PREVENTION OF CARDIOVASCULAR DISEASES O. Pachinger otmar.pachinger@tirol-kliniken Medical University of Innsbruck, Innsbruck, Austria higher in daughters (35.4%) and sons (26.7%) than in of all elementary school districts in the city of Nurem- fathers (15.7%) and mothers (10.6%) and hypertensi- berg participated in this study. Yearly surveys were on was 2.5 fold higher in mothers and 1.7 times higher performed in terms of structured interviews including in fathers. Youth exposed to second-hand smoke had The relationship of obesity to cardiovascular mortality cardiovascular disease prevention: prevention should personal and family history, physical activity, smoking a far more adverse risk profile. A 1 year’s follow-up un- has been recognized for many years. It also has been start early in life; adoption of a healthy life style is and nutritional habits, anthropometric examination, der real life conditions demonstrated that continuous recognized that overweight is associated with a shor- fundamental; focus on family and parenting; primary fasting blood analyses, seven days weighted dietary control and sustained counseling on healthy nutrition, ter life span. Cardiovascular consequences of obesity care is an important setting for population and high protocols. Yearly personal health passports and nu- recreational physical activity, and decreased tobacco involve atherosclerosis, hypertension, left ventricular risk approaches to prevention. The broad food and tritional protocols were used continuously amending smoke exposure is a realistic approach improving hypertrophy as direct cardiac consequences; in additi- activity environment must be understood for inter- the individual yearly counseling on healthy lifestyle. modifiable CVD risk factor profiles in healthy school on metabolic co-morbidities such as insuline resistan- ventions to be succesfull, education alone is unlikely ce, type II diabetes mellitus, dyslipidemia, metabolic to be effective. Therefore, focus on behaviour change Results and conclusions: Among 3038 adolescents syndrom are indirectly affecting the cardiovascular techniques; prevention approaches to diet and physi- abdominal adiposity in terms of elevated waist cir- References: 1. Schwandt P, Geiss HC, Ritter MM, system. In general, two approaches to prevention cal activity should be taylored to the age and develop- cumference (WC) and waist-to-height ratio (WHtR) Üblacker C, Parhofer KG, Otto C, Laubach E, Donner are recommended: 1. Population approach applies mental stage of the child. In cardiovascular disease was associated with a higher risk of hypertension (OR MG, Haas GM, Richter WO. The Prevention Education to everyone 2. High-risk approach: identification of prevention doctors need to play a major role and this 2.5), hypertriglyceridemia (OR 4.9), elevated LDL-C (OR Program (PEP). A prospective study of the efficacy of those at high risk and more intensive intervention needs to be improved! 2.0), low HDL-C (OR1.6) and fasting blood glucose (OR family-oriented life style modification in the reduc- 1.3)2. Based on our percentiles and others we preclu- tion of cardiovascular risk and disease: Design and de the use of a universal cutoff of 0.5 for WHtR3. The Baseline Data J Clin Epidemiol 1999; 52: 791-800. 2. prevalence of abdominal adiposity was similar to Ira- Schwandt P, Bertsch T, Haas GM. Anthropometric nian and Brazilian youth whereas dyslipidemia was screening for silent cardiovascular risk factors in ado- for these individuals. There are several principals for 34 gy consumption above the recommended level was Design: First graders and their families living in 94% children and their parents8. 35 7.3. LIPID LOWERING DRUGS AND LIPOPROTEIN APHERESIS lescents: The PEP Family Heart Study. Atherosclerosis J Obesity 2015; 39; 1508 6. Schwandt P, Bischoff-Fer- 2010; 211: 667 - 671. 3. Schwandt P, Haas GM. Is the rari HA, Staehelin HB, Haas GM. Cardiovascular risk ratio waist circumference to height of 0.5 a univer- screening in school children predicts risk in parents. sal measure for abdominal adiposity in children and Atherosclerosis 2009; 205: 626-631. 7. Schwandt P, adolescents? International J Obesity 2016; 40:1141- Haas GM, Liepold E. Lifestyle and cardiovascular risk 1142. 4. Schwandt P, Kelishadi R, Ribeiro RQC, Haas factors in 2001 child parent pairs: the PEP Family GM, Poursafa P. A three-country study on the compo- Heart Study. Atherosclerosis 2010; 213:642-648. 8. Children at high risk because of a family history of zygous and statin refractory heterozygous FH (HoFH, nents of the metabolic syndrome in youth: The BIG Schwandt P, Bertsch T, Haas GM. Sustained lifestyle premature CVD and/or hypercholesterolaemia should HeFH). However, the extent of cholesterol-lowering Study. Intern J Pediatric Obesity 2010; 5:334-341. 5. advice and cardiovascular risk factors in 687 biologi- be targeted. Other risk factors for Atherosclerotic achieved is often insufficient to meet the targets set Schwandt P, Haas GM. Why stigmatize overweight cal child-parent pairs: The PEP Family Heart Study. Cardiovascular Disease (ASCVD) such as hyperten- by current guidelines. The recent advent of three new young people as hypertensive by using normative Atherosclerosis 2011; 219: 937-945. sion, overweight and diabetes, should be also taken classes of lipid-lowering agents provides new hope into account. The measurement of other ASCVD risk that the latter objective may now be achievable. The- factors with prognostic value, such as the assessment se drugs act either by reducing low density lipoprotein of Lp(a), is currently strongly suggested. Pediatric lipo- (LDL) production by inhibiting apolipoprotein B syn- protein apheresis (LA) is an extracorporeal treatment thesis with an antisense oligonucleotide (mipomer- of children with genetically determined dyslipidaemi- sen) or by inhibiting microsomal triglyceride transfer as, namely Homozygous Familial Hypercholestero- protein (lomitapide), or by enhancing LDL catabolism laemia (HoFH), a pernicious disease characterized by via monoclonal antibody-mediated inhibition of the skin lesions, such as cutaneous xanthomas at birth or activity of proprotein convertase subtilisin/kexin 9 percentiles from non-overweight youth? International 7.1. NEW ASPECTS OF FAMILIAL HYPERCHOLESTEROLEMIA (FH) IN THE YOUTH K. Widhalm [email protected] Austrian Academic Institute for Clinical Nutrition and Department of Pediatrics, Medical University of Vienna, Vienna, Austria C. Stefanutti [email protected] Extracorporeal Therapeutic Techniques Unit - Lipid Clinic and Atherosclerosis Prevention Centre - Immunohematology and Transfusion Medicine - Umberto I Hospital - Department of Molecular Medicine, ‘Sapienza’ University of Rome, Rome, Italy The prevalence of FH is most probably 1:200 in the age of 4.5 years before undergoing any treatment. All by early childhood (eg, planar xanthomas, tuberous (PCSK9) (evolocumab). Depending on the outcome of European population. It is evident that only a very other patients are in a good condition however seve- xanthomas; later, tendon xanthomas), arcus corneae, current trials, it seems likely that these agents, used small minority of the affected young subjects is di- ral of them developed aortic stenosis. In the hetero- early atherosclerotic impairment of coronary arteries alone or combined with LA, will markedly improve agnosed and subsequently undergoing treatment. zygous FH patients dietary therapy seems to be the and aortic valve. HoFH children ASCVD risk is extre- the management of refractory FH. Unfortunately, the On the other hand it has been proved that athero- first column of treatment. Thus, recent data show that mely elevated. The natural history of these young and above mentioned novel lipid-lowering drugs have no sclerosic lesions in the subjects with FH can be seen substitution of animal protein by soy protein is able to very young patients, evolves towards exitus in the indication in the treatment of children, albeit clinical in the pediatric age group and these manifestations lower LDL-C levels by approx. 10%; by this treatment 1st or 2nd decade of life, if appropriate and intensive trials on the use of PCSK9 inhibitors in children are can be reversed by adequate treatment. An excellent in about 1/3 of young children, drug treatment can treatment is not warranted. At present, LA, combined on the way. At least for now, LA remains the mainstay example of this phenomenon is the rare form of FH be postponed. Obviously the introduction of drugs with high-dose statin and ezetimibe therapy, is the therapy for children at very high ASCVD risk. in the homozygous form. 9 patients with hoFH have is the appropriate way of treatment in children and best available means of treating patients with homo- been diagnosed and consequently treated (mostly adolescents with FH. There are strong arguments to with LDL-apheresis and drugs) in the Vienna group force the introduction of new drugs like the PCSK-9 within the last 35 years. The oldest patient survived inhibitors even in childhood in order to improve the until the age of 36 years. He suddenly died on an acu- outcome and the inhibition of atherosclerotic lesions te myocardial infarction. The youngest patient (with a in young patients. very aggressive LDL-receptor gen mutation) died at an 36 37 7.4. NEW DRUGS: MECHANISM OF ACTION 7.5.B. MAKING THE DIFFERENCE: THE IMPORTANT ROLE OF FH PATIENT ORGANIZATIONS G. M. Kostner [email protected] Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria J. Payne [email protected] HEART UK - The Cholesterol Charity, Maidenhead, Berkshire, United Kingdom Plasma lipids involved in atherogenesis are choles- or by increasing their catabolism. To the first category Jules Payne is Chief Executive of HEART UK - The Cho- applied. Jules is also Chair of FH Europe - A Europe- terol and triglycerides (TG). Whereas the role of TG as belongs Niacin, MTP inhibitors and the new RNA inter- lesterol Charity, a patient and professional organisati- an FH patient network of 24 countries. The network risk factor for CVD is still under debate, there is no ference dugs like mipomersen or ISIS-APO(a)Rx from on providing expert support, guidance and education was set up in March 2015 and they share a vision to doubt that the culprit is cholesterol. Cholesterol is IONIS. The most promising new drug, however are to patients, their families and health care professio- identify all the FH cases in Europe. These organisa- transported in HDL as the “god cholesterol” and in LDL the PCSK9 inhibitors that may be administered addi- nals treating those patients with high cholesterol and tions come together to share best practice and sup- and Lp(a) as the bad. The strategy to combat CVD is to tionally to statins. At the appropriate dosage PCSK9 other lipid conditions. She will cover some of the port each other whilst raising awareness of FH. It’s raise HDL and to lower LDL and Lp(a). Niacin has been inhibitors effectively lower LDL to the target values most recent activities which HEART UK are doing to better together! Jules will share the planned activities propagated for HDL-raising but it is not sold anymore proposed in most guidelines. The mode of action of raise awareness of the dangers of high cholesterol, in that have raised awareness around Europe and the in most countries. The lowering of LDL and Lp(a) may all these drugs will be discussed. particular FH. She will discuss their Ambassador pro- world and future plans around lobbying European gramme and their newly planned Children and Young Parliament, providing support for each country to ef- People’s Programme. As well as these activities she fectively lobby the Government in their own country, will also cover how HEART UK managed to overturn attending health care professional conferences and the decision of NICE to recommend a new category holding network meetings and more. This talk will de- of drug and also how their activities keep the matter monstrate the importance of patient involvement and high on the political agenda in the UK, which is star- the power they can have. be achieved by reducing the rate of their biosynthesis, 7.5.A. PATIENT ORGANIZATIONS AND THE MEDICAL & SCIENCE COMMUNITY: A PERFECT TEAM G. Hanauer-Mader [email protected] FHchol Austria, Vienna, Austria 38 ting to get traction, but pressure will continue to be From personal suffering to the collective mission: tific data and findings a face and are thus an important Starting from my personal story of familial hypercho- voice for science & medicine.Empowered patients can lesterolemia and my daughter‘s being severly affec- educate other patients, they know about their risks and ted by this condition, I will speak about my personal have a better compliance. Also, they can raise public motivation to form the first FH advocacy group in the awareness through emotions and thus put pressure on German-speaking countries in 2004 which eventually public health authorities. Awareness raising, lobbying, turned into the FHchol Austria Patient Organization in media relations: In the course of my lecture I will also 2011 and into a collective mission. Patients, clinicians & give a few examples of how the FHchol Austria patient scientists - a powerful team: I will then lecture on a po- organization is addressing a broader public and politi- werful liaison: the joining forces of patients, clinicians cians (for instance through our press conferences and & scientists.While scientists are the experts in basic re- media relations efforts, FH Awareness Days supported search and drug development, clinicians are experts in by local politicians, workshops, lectures, conferences, the direct communication with and treatment of pati- etc.)Our political pressure targets primary prevention ents.Patients, on the other hand, show that prevention through early screening & treatment, reimbursement of CVD is possible despite their chronic condition. They of innovative medication or the establishment of an are role models for other patients and they are the Austrian-wide FH registry. International cooperation - faces of FH. Empowered patients: Empowerd patients FH Europe: Last but not least I will talk about internati- are EXPERTS of their own condition. They do, however, onal cooperation, above all about my trusteeship in FH not compete with science or the medical community - Europe, the European FH Patient Network, which will they are EQUAL partners. By joining forces with science then be presented separately by FH Europe President & clinicians, they start a fruitful dialog. They give scien- and Heart UK CEO Jules Payne. 39 POSTER PRESENTATIONS – SUBMITTED ABSTRACTS P1.01. USING ONLINE PROGRAM OF GOOD NUTRITION AND WRIGHT DIET: PREVENTION AND PART OF THE TREATMENT OF OBESITY AND CARDIOVASCULAR DISEASES V. Krylov [email protected] LLC Right Diet, Moscow, Russian Federation Objective: It is too much easier and cheaper to pre- and 100 patients control group who were given the vent obesity, than in the future to treat it’s complica- same recommendations on the appointment. Persis- tions. tent decrease in body weight by an average of 6.5 kg L. G. Porciuncula1,2, E. Esposo1, K. Ang1, K. Yap1 [email protected] 1 St. Luke‘s Medical Center, Quezon City, Philippines, 2HB Calleja Heart and Vascular Institute, Quezon City, Philippines Objectives: To validate the American College of Sur- 22 (7.7%) patients, pneumonia in 11 (3.8%) patients, gery, National Surgical Quality Improvement Program major cardiac event 1 (0.3%) patient, urinary tract (ACS NSQIP) in predicting risk for developing major infection in 4 (1.4%) patients, venous thromboem- cardiovascular event (MACE) peri-operatively. bolism in 1 (0.3%) patient, renal failure in 4 (1.4%) patients, and return to operating room in 3 (1%). Average length of hospital stay was 4.76 (SD 5.22) days. Design: Prospective cohort validity study. The purpose of this study was to compare the RCRI over six months was demonstrated in all patients of Setting: St. Luke’s Medical Center, Quezon City, and ACS NSQIP risk stratification in predicting risk for Methods: We used an online system for patient the main group, we also found it out that systolic and November-December 2015. MACE of patients undergoing non cardiac surgeries. education based on the video lessons, full of humor, diastolic blood pressure levels decreased more than 9 pictures, and cartoons to convey the necessary infor- mm Hg, the consumption of milk and dairy products Participants: All patients 18 years old and above, ACS-NSQIP based on specificity and AUC. RCRI exhi- mation on good nutrition, necessary to do exercises increased by 2.6 times, compared with patients in the with infarction bited a sensitivity of 100% and specificity of 98%, and the need for exposure to the sun to our patients. control group. The exposure to the sun was observed documented as present on admission, given dual corresponding to a positive likelihood ratio of +57, a 15 to 30 minutes daily, compared with the control anti-platelets and anticoagulation. PPV of 17% and a NPV of 100%. ACS-NSQIP showed a RCRI showed better accuracy indices compared to ST-segment-elevation myocardial sensitivity of 100% and specificity of 92%, correspon- Results: Watching the short movies, the patients group 5-10 minutes. Regular physical activity was in formed the habits of good nutrition during the first the main group of 260 minutes per week, in control Main outcome measures: Main outcome measures ding to a positive likelihood ratio of +12.8, a PPV of month already, which includes a diet with restriction group 80 minutes. were occurrence of cardiac and non cardiac morbidi- 4.4% and a NPV of 100%. ACS-NSQIP risk index is a ties within 30 days of admission: mortality, morbidity, reliable preoperative assessment tool to identify patient who have low risk for MACE. of fat, digestible carbohydrates and daily consump- 40 P1.02. PROSPECTIVE VALIDATION OF AMERICAN COLLEGE OF SURGEON QUALITY IMPROVEMENT PROGRAM RISK SCORE IN PREDICTING MAJOR CARDIOVASCULAR EVENTS PERI-OPERATIVELY tion of low-fat dairy products, slow carbohydrates, Conclusions: Mobile and wireless technology helps major cardiac events, pneumonia, surgical site infecti- protein and fiber. Were also presented recommenda- physicians to combat obesity and be a part of the tre- on, urinary tract infection, venous thromboembolism, tions for compliance with the physical activity, as well atment of Diabetes Mellitus and Cardiovascular disea- and renal failure. as vitamin D consumption. A patient was in touch with ses and we need to improve the quality of information a doctor-endocrinologist. We examined data from a material, including using online technologies to im- Results: Among 286 patients, in-hospital death ring in detecting mortality, cardiac and non-cardiac survey of 500 patients registered in the online system prove the quality and duration of life of our patients. occurred in three (1%) patients, major morbidity in morbidities. Conclusion: Based on this study, the ACS NSQIP risk scoring has better predictive ability than RCRI risk sco- 41 P1.03. VISCERAL ADIPOSITY CALCULATOR FROM THE DALLAS HEART STUDY: POPULATION BASED RISK ESTIMATOR FOR VISCERAL ADIPOSE TISSUE AND ASSOCIATED CARDIOVASCULAR RISK P1.04. IMPACT OF A MULTIDISCIPLINARY LIFESTYLE INTERVENTION DURING THE AGE OF GROWTH C. Ranucci, V. Gianfredi, R. Pippi, C. Aiello, L. Buratta, N. Piana, E. Reginato, A. Tirimagni, E. Chiodini, E. Sbroma, A. Gili, P. De Feo, C. Mazzeschi [email protected] università degli studi di Perugia, Perugia, Italy U. Akhtar, N. Kondamudi, C. Ayers, I. J. Neeland [email protected] UT Southwestern Medical Center, Dallas, TX, United States Background: Visceral adipose tissue (VAT) is a stron- Discussion: The predictors of VAT noted in our model Introduction: Childhood obesity is one of the most for six months for children and three months for ado- ger risk factor for insulin resistance, type 2 diabe- are consistent with the literature. Those commonly serious public health problems in our time. The pre- lescents. Before and after the intervention, several tes, hypertension, and cardiovascular disease than linked to VAT in prior studies include WC, TG/HDL, vention and the treatment of childhood obesity is anthropometric measures (height, body weight, Body subcutaneous adipose tissue. Although VAT can race, and age, which at times show an interdependent complex and requires a multi-component approach Mass Index, waist circumference, waist-to-height be accurately measured using dedicated imaging relationship. These past studies were mainly limited involving the family and addressing individual and ratio, body composition) and nutrition habits of the techniques such as CT or MRI, implementation of the- to unidimensional analysis. The strength of our model social aspects. The purpose of the present study is participants and their families were evaluated. In se modalities remains limited in clinical practice due lies not only in the utilization of a larger, more diverse to examine the impact of a multidisciplinary lifestyle addition, a set of functional motor fitness tests was to high cost, radiation exposure, and prolonged scan population than prior studies, but also in the incorpo- intervention to treat overweight/obese children and performed to evaluate the aerobic capacity, speed, time. We used data from the Dallas Heart Study to cre- ration of a wide breadth of clinically expedient varia- adolescents on: (1) changes in body composition; (2) flexibility and dynamic muscle strength. ate a clinically feasible surrogate model for VAT. bles. Our study provides a model that can be incor- adherence to a Mediterranean diet; and (3) physical porated as a surrogate for VAT into risk stratification performance. The lifestyle intervention for children Results: After the intervention both children and paradigms. and adolescents has been designed with a multi-com- adolescents significantly reduced their BMI, waist cir- cardiovascular disease underwent measurement of ponent family-based approach, it is based on the ex- cumference, WHTR and fat mass, and improved fat anthropometrics, laboratory data, and VAT by MRI perience of the C.U.R.I.A.Mo. model, already experi- free mass, adherence to the Mediterranean diet and between 2000-2002. Sex-specific, multivariable back- mented for adult obesity. physical fitness performance. Conclusion: The results Methods: 2,319 participants without diabetes or wards elimination models were created to optimize of this multidisciplinary intervention are encouraging the clinical prediction of VAT and validated through Materials and Methods: The study involved 74 over- regarding the effectiveness in the short term in ame- bootstrapping. weight/obese children (aged 5-12) or adolescents liorating the health status and the nutrition habits of (aged 13-17). The intervention was multidisciplinary children and adolescents. It remains to demonstrate Results: Mean age of the cohort was 44 years with including nutrition, exercise and psychological as- the long-term efficacy of the intervention. 55% women and 46% African-Americans. The variab- pects and a family-based approach; it was delivered les included in the final model for women were age, weight circumference (WC), TG/HDL, black race, and serum glucose, and for men were age, WC, TG/HDL, black race, and serum uric acid. The adjusted R2 was 0.64 for women, and 0.69 for men (P < 0.0001). 42 43 P1.05. PUBLIC PERCEPTION OF THE INTRODUCTION OF A SUGAR-SWEETENED BEVERAGE TAX IN TRINIDAD: A CARIBBEAN PERSPECTIVE P1.06. EFFECTS OF A TWO-YEAR ADDITIONAL PHYSICAL EDUCATION CLASS INTERVENTION ON CHANGES IN MOTOR SKILLS IN ELEMENTARY SCHOOL CHILDREN K. D. Rocke, A. Garib, A. Ramcharitar-Bourne, S. D. Nichols, N. O. Dalrymple [email protected] The University of the West Indies, St. Augustine, Trinidad and Tobago R. Hauer, H. Tschan [email protected] Universitiy of Vienna - Centre for Sport Science, Vienna, Austria Introduction: Sugar-sweetened beverages have beco- sing (28%). A 5% increase was most favourable among Introduction: Physical inactive children are two times Conclusions: Resent research already shows the im- me a target of anti-obesity initiatives because of in- participants. Higher BMI (OR= 1.06; 95% CI= 1.01, 1.11; as likely to be obese as adults [3]. Nevertheless, only portance of PA and the resulting health benefits for creasing evidence of their link to obesity. Few studies p=0.009) and consumption of non-sweetened bever- a small number of children fulfill the physical activity children. The preliminary results of this study give have explored attitudes towards sugar sweetened ages (OR= 1.39; 95% CI= 1.17, 1.65; p=<0.001) were (PA) recommendations. Several research indicate that evidence that PETH can play an important role to beverage (SSB) taxation, with none to date at the local more likely to be significantly associated with greater more school sport can have positive effects in child- improve physical development in elementary school level. This study therefore sought to investigate the support of the SSB tax. Those who were earning a ren physical development [1, 2]. Therefore, the aim children. public’s perception of an introduction of such a tax in monthly income of <$5.000 Trinidad and Tobago Dol- of this current pilot study is to analyze the effects of Trinidad. lars (TTD) and consuming higher quantities of sweete- additional physical education teaching hours (PETH) in References: [1] Augste, C. & Künzell, S. (2014) J Sports ned non-alcoholic and alcoholic beverages were sig- elementary school children. Sci., 32 (5), 415-423. [2] Reed, K. et al. (2008) Preven- Materials and Methods: A cross-sectional study of nificantly associated (p<0.001) with opposition to the 800 adults (aged >18 years) was conducted in Trini- implementation of the SSB tax. dad. Perception of the introduction of an SSB tax and tive Medicine, 46, 525-531. [3] Nike, Inc. (2013). DesiMethods: In addition to regular PETH two additional gned to move report. hours were added per week for an intervention class other correlates were assessed using self-administe- Conclusion: Overall the public was undecided on the (INT). Two times during the school year, children mo- red questionnaires. Predictors of support and opposi- implementation of an SSB tax. Although the introduc- tor abilities were tested using the German Motor Test tion to the tax, such as beverage consumption and so- tion of such a tax appeared to be relatively favourab- (DTM). This test evaluates strength, speed, coordina- cio-demographic and lifestyle factors were explored le among the general public, consideration must be tion, endurance and flexibility. All collected data for using multinomial logistic regression models. given to sociodemographic, lifestyle and behavioural the first two years have been compared to an equal factors. Public consultation with public health officials, control class (CON). Additionally, test results of the Results: Most participants were neither in support nor international organizations, the government and the INT were compared with standard values for the DTM. in opposition of the introduction of an SSB tax (42%), general public is needed to ascertain the acceptance Statistical significance was set at p ≤ 0.05. followed by those in support (30%) and those oppo- of introducing such a public health policy at the local level. Results: At baseline, the INT had significant better values in strength, coordination and flexibility than the CON. On the other hand, CON showed significant better endurance results than INT. After one year of intervention, INT still had significant better values, but also showed an improvement in endurance with significant better results than CON. Similarly, after two school years of intervention children showed higher results for strength, coordination and flexibility compared to standard values. 44 45 P1.07. SUSTAINABLE LIFESTYLE. THE SIZE OF THE ECOLOGICAL FOOTPRINT IN RELATION TO BODY MASS P1.08. PSYCHOLOGICAL ASPECTS OF EATING BEHAVIOR AND MOTIVATION FOR PHYSICAL ACTIVITY IN VIENNESE ADOLESCENTS L. Heim, Z. Lelovics [email protected] Kaposvár University, Kaposvár, Hungary T. Vlasak1, J. P. A. Aden1, A. Bunina1, Z. Kovacovsky1, C. Pöppelmeyer2, K. Widhalm2 [email protected] 1 Sigmund Freud University Vienna, Vienna, Austria, 2Austrian Academic Institute for Clinical Nutrition, Vienna, Austria Background: Al Gore pointed out that global warming Results: When calculating the ecological footprint the The age range of the middle-aged youth is not only Results: An analysis of the results in the field of physi- is caused by the combination of various human average score was 370 ± 72 points, corresponding to characterized by the analysis of development tasks cal acitivity showed that 15.1% of the examined adole- activities, thus nutrition and lifestyle are among those 6.0-7.8 hectares. Overweight participants reached lo- but also by the formation and solidification of the per- scents rarely do sports for fun and pleasure. I addition influencing factors. wer (363 ± 74 points), while underweight participants sonal health behavior. This particular context raises to this the results of the examined adolescents are be- (372 ± 77 points), participants with optimal body the question in which extent young people are affec- low average. Moreover the results showed that about Aims: Assessing the ecological footprint of the weight (372 ± 72 points) and obese participants (379 ± ted by dysfunctional behaviors regarding the lifestyle 18% of the sample have an above-average depen- population of Somogy County in relation to the body 60 points) reached higher scores. The difference was factors „eating behaviour“ and „physical activity. Star- dence on overeating and snacking and only a small mass index (BMI, WHO 2007). Comparing and asses- not significant in any of the cases. The footprints cor- ting from an understanding of positive health, that the possibility of control in situations of craving. In addi- sing the differences of the ecological footprint among responding with the scores are not dependent on BMI promotion of functional settings and custom patterns tion, 16.2% of young people have an above-average people with optimal body mass and overweight/obese (6.0-7.8 hectares as well). is prioritized, an analysis of the status quo of young tendency to increased eating in emotional situations.. people was found to be advisable. In the present stu- people. Conclusions: Since the 1992 Conference in Rio the dy therefore aspects and behaviors with respect to Conclusion: Considering the results some loss-ma- Materials and methods: The authors used Eric Krau- desired sustainable consumption behavioral patterns diet and exercise for both of overweight affected, as king behavior patterns of young people in dealing se’s calculating method with an anonymous voluntary are included among the international harmonization well as non-affected children and young people are with exercise and diet can be displayed, suggesting self-completed ecological footprint questionnaire topics. Among the topics, besides waste management analyzed and relevant information is derived there- interventions. Nevertheless the study pointed out re- (n = 267; 36.5% male, average age 27,0 ± 8.5 years). and energy saving issues nutritional and food proces- from. sources in the field of cognitive control on which can The ratio of the participants with optimal body mass, sing related activities are also included. Based on our overweight and obese participants were 67.4%; 18.7% results, using the given examination method, there Method: In a sample of n = 118 adolescents aged 11 and 5.2% respectively (18,5 ≥ BMI 8.6%). In the valid is no significant difference among the different BMI to 13 were measured by AD-EVAs (Ardelt Gattinger & assessment there are three questions concerning the categories. Meindl, 2010) the FEV-Salut-S, the FEV-Path-S, the FEV- nutritional habits, dealing with the frequency of meat be built upon in the future. Path-EE, FEV Path -K and FUN. and fish consumption and the purchasing attitudes of homemade and domestic/local foods. 46 47 P1.09. RELEVANCE OF FAMILY SITUATION FOR HABITUAL EATING BEHAVIOUR AND ITS IMPLICATIONS FOR THERAPEUTIC INTERVENTION MEASURES P1.10. COMPARISION OF PHYSICAL ACTIVITY BETWEEN EDDY YOUNG PARTICIPANTS AND STANDARD VALUES J. P. A. Aden1, K. Koller1, A. Mayer1, C. Pöppelmeyer2, K. Widhalm2 [email protected] 1 Sigmund Freud University Vienna, Vienna, Austria, 2Austrian Academic Institute for Clinical Nutrition, Vienna, Austria T. Knopf1, R. Hauer2, C. Pöppelmeyer1, H. Tschan2, L. Stocker2, S. Gattermeyer3, A. Bunina3, J. P. A. Aden3, O. Pachinger4, K. Widhalm1 [email protected] 1 Austrian Academic Institute for Clinical Nutrition, Vienna, Austria, 2Centre for Sport Science and University Sports, Vienna, Austria, 3 Sigmund Freud University Vienna, Vienna, Austria, 4Austrian Heart Foundation, Vienna, Austria Background: Due to an increasing rate of obesity in (32.6%) more often than children who live with a sing- Introduction: The prevalence of overweight and obe- Results: The results indicate that in comparison to the child- and young-adulthood, the need for intervention le parent (TV: 21.1%; Fastfood: 47.4%; Sweets: 10.5%; sity has reached alarming rates in the European Uni- standard value 22.5% where average, 11.3% above measures is rising as well. As for the emergence and Between 15.8%) or those who live with their grandpa- on and the numbers are still rising (Wolf-Dietrich, et average and 46.5% where below average. 2.8% of the maintenance of adiposity and overweight, three fac- rents (TV: 5%; Fast Food: 40%; Sweets: 20%; Between: al., 2006). A study in Germany found out that obesi- subjects where highly above average and 16.9% highly tors seem to be crucial: Biological, psychological and 5%). This means, that even though children living with ty as a disease is found in 48% of all schoolchildren. below average. social factors. With examining the family situation of their parents show lower BMI percentile on average Overweight children have a high risk to become over- a child’s caretakers, the implications on the eating be- (MD=75.8) than children living in different housing weight adults with a high risk for the occurrence of Discussion: The results are showing that more than haviour and selected anthropomorphic markers can situations (grandparents: MD=81.45; single parent: type 2 diabetes, cardiovascular, orthopedic, and other the half of the subjects are below average. Therefore be elicited. MD=84.1) the parenting styles of the latter seem to diseases (Wabitsch, 2004). The aim of this study is to it is important to raise awareness of a healthy nutriti- discipline the children’s eating behaviour in a stricter raise awareness and to prevent children to get over- on and increase physical activity already in early age. way. weight individuals. The present study will continue two more years and res, the data used is collected in form of questionnai- Discussion: Especially the organisation of eating hab- Methods: Regarding methodology section this study res, which examines children’s eating behaviour, the its differs in each of the family situations. Primarily the follows a qualitative research including the German amount of different foods they eat, as well as their single parent households as well as the households in motorik test which is tailored for children and adole- knowledge about a healthy diet. The sample consists which grandparents take part in parenting show res- scence (http://www.sport.kit.edu/dmt/). The subjects of N=174 children between the age from seven to trictive and strict forms of organisation. Intervention had to follow 8 different sport tasks. The test is made nine. measures integrating the family surroundings should from the German institute of sport and sport sciences. therefore take account to the different conditions and The evaluation of the test was done with the program requirements of the diverse family situations. regarding to the test. The sample of this study inclu- Methods: The present abstract uses data from the “Eddy-Projekt. Apart from anthropomorphic measu- Results: Children who are living with both their parents eat more often in front of the TV (51.1%), pre- 5 more tests will show if the prevention program of Eddy Young achieves success. des 71 children which are between 8 and 10 years old. fer fast food to a greater extent (68.9%) and also eat sweets after meals (39.3%) as well as between meals 48 49 P2.01. WAIST CIRCUMFERENCE AND WAIST-TO HEIGHT RATIO PREDICT SODIUM INTAKE AMONG CARIBBEAN ADULTS K. D. Rocke, S. D. Nichols, N. O. Dalrymple, A. Ramcharitar-Bourne [email protected] The University of the West Indies, St. Augustine, Trinidad and Tobago P2.02. FASTING HYPERGLUCAGONEMIAIS ASSOCIATED WITH GLUCOSE INTOLERANCE, HIGH PLASMA TRIGLYCERIDES AND VISCERALADIPOSITY IN OBESE CHILDREN AND ADOLESCENTS H. Manell1,2, H. Kristinsson1, J. Kullberg3, K. Paulmichl4,5, J. Staaf1,6, J. Cadamuro7, F. Zsoldos4,5, S. Göpel8, E. Sargsyan1, H. Ahlström3, D. Weghuber4,5, A. Forslund6, P. Bergsten1 [email protected] 1 Dept. of Medical Cell Biology, Uppsala University, Uppsala, Sweden, 2Dept. of Women’s and Children’s Health, Uppsala University, Uppsala, Swaziland, 3Dept. of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden, 4Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria, 5Obesity Research Unit, Paracelsus Medical University, Salzburg, Austria, 6Dept. of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden, 7Dept. of Laboratory Medicine, Paracelsus Medical University, Salzburg, Austria, 8AstraZeneca R&D, Mölndal, Syrian Arab Republic Introduction: Habitual high levels of sodium intake be 3.107 ± 44.41 mg/day. Sodium intakes adjusted for may be linked to the development of hypertension age, gender, calories, family history of hypertension, and diabetes mellitus - contributors to over 50% of diabetes mellitus, heart disease, and BMI were posi- annual visits to healthcare facilities in the Caribbean. tively associated with waist circumference and waist- Overweight and obesity remain consistent risk factors to-height ratio. Elevated waist circumference (females for these conditions. In this study, we examined the > 34 inches; males >40 inches) and waist-to-height Introduction: Type 2 diabetes (T2D) development by magnetic resonance imaging. These associations association between anthropometric indices of over- ratio (≥0.5) were associated with high sodium intake in children and adolescents is a growing health con- were independent of BMI, age, gender and family weight and obesity and sodium intake. (>2400 mg/day) - odds ratio (OR); 1.38; 95% CI 1.02, cern and the connection between obesity and T2D is history of diabetes. Exposure of human islets to 0.5 1.87; p<0.05) and 1.28; 95% CI 1.01, 1.64; p<0.05) res- well established. Recently, elevated glucagon levels mM palmitate doubled glucagon secretion at fasting pectively. BMI was not associated with sodium intake. have attracted more attention as contributing factor glucose concentrations. Materials and Methods: A cross-section of residents completed a structured self-administered questi- to development of the disease but glucagon release onnaire consisting of demographic, health history Conclusions: It this study, elevated waist circumferen- patterns in children and adolescents with obesity are Summary: Collectively, this demonstrates a connec- and food frequency items. Dietary sodium intake was ce and waist-to-height ratio were associated with high poorly investigated. tion between fasting hyperglucagonemia and increa- obtained using a food frequency questionnaire cont- sodium intake. Persons in this population with eleva- aining 120 items which were analysed for sodium and ted central adiposity may be at an increased risk for Methods: Here we investigated fasting circulating le- adolescents with obesity, where the glucagonotropic calories. Anthropometry was self-reported. Partici- conditions associated with high sodium intakes. vels of glucagon and lipids in children and adolescents effect of fatty acids is a potential underlying mecha- pants giving both oral and written consent were en- with obesity and lean controls and glucagon secretion nism. rolled in the study. Participation was voluntary. from isolated human islets exposed to fasting glucose sed visceral adiposity and blood lipids in children and concentrations and elevated concentrations of fatty Results: Two thousand, three hundred and forty-three acids observed in children with obesity. individuals (females = 1.277; males = 1.066) participated in the study. Mean sodium intake was found to Results: In children and adolescents high fasting plasma glucagon was associated with high BMI, waist circumference, 2-hour plasma glucose, fasting HbA1c, insulin and triglycerides and low HDL-cholesterol. Elevated fasting glucagon levels were also associated with large visceral adipose tissue volume, quantified 50 51 P3.01. WHICH IS THE BEST BIOMAKER TO PREDECT CARDIOVASCULAR EVENTS IN THE APPARENTLY HEALTHY JAPANESE OBESE POPULATION?: C-REACTIVE PROTEIN, URINE ALBUMIN, B-TYPE NATRIURETIC PEPTIDE, AND GLOMERULAR FILTRATION RATE P3.02. THE RELATIONSHIP BETWEEN SERUM URIC ACID AND LEFT VENTRICULAR HYPERTROPHY IN OVERWEIGHT AND OBESE CHILDREN Y. Matsuura1, M. Honma1, S. Takahashi1, F. Tanaka1, K. Tanno1, K. Sakata1, A. Okayama2, M. Nakamura1 [email protected] 1 Iwate Med Univ, Morioka, Iwate, Japan, 2Research Institute for Lifestyle-Related Disease Prevention, Tokyo, Japan B. Bjelakovic1, N. Kavaric2, G. Kocic3, A. Klisic4, M. Jovic3, L. Saranac1, T. Jevtovic-Stoimenov3 [email protected] 1 Clinic of Pediatrics, Clinical Center, Nis, Serbia, Medical faculty, University of Nis, Nis, Serbia, 2Primary Health Care Center, Podgorica, Montenegro, Podgorica, Montenegro, 3Medical faculty, University of Nis, Nis, Serbia, 4Primary Health Care Center, Podgorica, Montenegro, Montenegro, Serbia Background: protein Results: The mean follow up period of the study was Introduction: Except dyslipidemia, insulin resistance, Results: We found statistically significant correlation (hsCRP), B-type natriuretic peptide (BNP), urinary al- 8.8 years. The hazard ratios for CVE onset in terms and autonomic disbalance, metabolic syndrome also between the serum concentration of the uric acid and bumin (UA) and estimated glomerular filtration rate of per 1SD increment (as a continuous variable) and encompasses chronic systemic inflammation. As the index of the myocardial mass (r=0.33, p=0.03) as well (eGFR) have been suggested to be useful predictors values above the 80th percentile (as a categorical one of the most important endogenous metaboli- as between uric acid and RWT (r=0.4 p=0.005) in all for the development of cardiovascular events (CVE) in variable) for each biomarker level were determined te with a protective anti-inflammatory, uric acid has children. After controlling for body mass index, only the general population. However, it remains unknown (Table). In addition, the area under the curve of ROC attracted scientific attention in the last decade. The correlation between RWT and uric acid persisted which biomarker is the most useful predictor for CVE analysis for CVE prediction for hsCRP (95% CI; 0.637 - practical clinical question is to define the relationship (r=0.287 p=0.05). specifically in the apparently healthy obese populati- 0.711) was significantly higher than those of the other between the uric acid and cardiac hypertrophy in obe- on. biomarkers (95% CI; 0.536 - 0.616). se children. The aim of the study was to examine the Conclusion: We can conclude that serum uric acid relationship between serum uric acid concentration concentration in overweight or obese children, corre- High sensitivity C-reactive Methods: Obese subjects as defined by BMI more Conclusion: Increased levels of hsCRP are superior to and left ventricular (LV) geometry in overweight and late with relative wall thickness but not left ventricular than 30 (n=642, mean age 62, women 81%) were rec- BNP, eGFR or UACR for risk assessment for the future obese children with or without metabolic syndrome. mass index. ruited from the Japanese general population. Baseline onset of CVE in apparently healthy obese subjects. blood levels of BNP and hsCRP, and UA corrected by Patients and methods: In a retrospective study a to- urinary creatinine (UACR), and estimated GFR were tal of 48 overweight or obese children were examined determined. Admission cases of CVEs (composite Apart from the standard laboratory analyses, body endpoint; myocardial infarction or stroke) were pro- mass index and serum uric acid concentration were spectively recorded by the regional registration. For measured. To define left ventricular geometry we each biomarker, a multivariate Cox regression analy- also determined myocardial mass index by M-mode sis adjusting for traditional risk factors (age, sex, BMI, echocardiography using Devereux formula indexed hypertension, diabetes, hyperlipidemia, atrial fibrilla- by body hight as well relative wall thickness (RWT) de- tion, smoking) was performed to examine the relative fined as LV wall thickness + septal thickness relative to risk for new onset of CVE. the internal dimensions of the LV . Hazard Ratio* per 1SD increment (95%CI) p-value Hazard Ratio* above 80 percentile (95%CI) p-value hsCRP 1.54 (1.15-2.08) 0.001 3.88 (1.88-8.00) 0.004 BNP 1.28 (0.84-1.97) 0.748 0.88 (0.40-1.95) 0.252 eGFR 1.16 (0.75-1.80) 0.122 3.43 (0.72-16.35) 0.494 UACR 1.45(0.82-2.55) 0.116 1.75 (0.87-3.50) 0.196 *Hazard ratios were adjusted for age, sex, BMI, diabetes, hypercholesterolemia, Af, hypertension and smoking. 52 53 P3.03. SCREENING OF NUTRITIONAL STATUS OF MARFAN SYNDROME PATIENTS A. Kiss1, Z. Lelovics2 [email protected] 1 Szent István University, Budapest, Hungary, 2Kaposvár University, Kaposvár, Hungary P3.04. AN OVERVIEW OF THE BODYWEIGHT IN VIENNESE PRIMARY SCHOOL CHILDREN: FIRST RESULTS FROM THE EDDY YOUNG STUDY C. Pöppelmeyer1, J. P. A. Aden2, O. Helk1, O. Pachinger1, K. Widhalm1 [email protected] 1 Austrian Institue for Clinical Nutrition, Vienna, Austria, 2Psychological Department Sigmund Freud University Vienna, Vienna, Austria Introduction: Marfan syndrome is a genetic disorder loss is also 8.8%. We found that the effect of acute ill- of the connective tissue, which affects approximately nesses on the malnutrition risk is 10.5%. The rate of Overweight and obesity are rising problems in Euro- higher than the percentage of extremely under- 2.000-3.000 individuals in Hungary. It is multi-syste- overweight is twice as often among men than women, pe. Therefore the WHO declared the prevention of weight boys (2.1%). In total 6.8% of the girls and 4.2% mic manifestations, this disorder is often difficult to (25.0 ≤ BMI < 30.0), on the whole the rate of over- overweight as a high priority research aim. The EDDY of the boys are underweight. About a quarter of the diagnose. To date, the National Marfan Register sys- weight is 30.7%. The rate of obesity (30.0 ≤ BMI < 40.0) Young study is an interventional cohort study in Vien- male participants (24.2%) and 15.9% of the femal sub- tem contains approximately 250 cases. Our goal is to is equal among man and woman (7.0-7.0%). The nese primary school children which aimes to achieve a jects have an increased waist circumference. In total assess the nutrition and nutritional status of Hungari- authors didnt cope extreme obes (40.0 ≤ BMI) sustainable change in eating habits and physical activi- 18.6% of the subjects have increased body fat (girls: an patients suffering from Marfan syndrome. Marfan-syndrome patients during the study. ty to combat obesity and its consequences. Anthropo- 12.2%, boys 24.2%). First anthropometric data from metric data from n=183 primary school children aged the EDDY YOUNG study indicate a rising prevalence Materials and Methods: We screened in 2014 the nutritional status of 114 voluntary Marfan-syndrome Conclusions: Based on the reference of the European 6-11 years were collected by bioimpedance analysis. of overweight and obesity in Austrian primary school patient elder than 18 years with the validated Malnu- Union, national health care systems need to attend Additionally height as well as waist and hip circumfe- children. The percentage of overweight is significant- trition Universal Screening Tool (MUST), and with the particularly to the recognition of rare diseases, and to rence was measured. In our sample 37.5% of the sub- ly higher in comparison to the data of the previous Food Frequency Questionnaire for valid nutritional the development of patient treatment. The screening jects are overweight or obese. On the other hand 5.5% EDDY Study in 11-14 aged adolescents (+12.9%). No- status assessment. nutritional status of Marfan syndrome patients also of the subjects are classified as underweight or mas- table is the considerable amount of 19.7% obese sub- provides new opportunities to study Hungarian pati- siv underweight (3.3%). The gender-specific analysis jects (previous EDDY Study: 6%). The results underline Results: According to our results the risk of malnu- ents with Marfan syndrome. To reduce the prevalen- shows that the overweight is more pronounced in the the importance of establishing successful prevention trition for these people is high (25.5%), but the pre- ce of malnutrition important to screen the nutritional boys (43.2%) that in the girls (31.8%). In particular the concepts to influence young childrens lifestyle and ea- valence of the malnutrition depends on the assessed status. Along malnutrition the problems of overweight amount of obese is considerably higher in the boys ting behavior with permanent age- appropriated lifes- and number of those parameters. The proportion of and obesity are a danger to medical condition of Mar- (25.3%) than in the girls (13.9%), whereas the percen- tyle interventions starting in primary school. malnutrition among people according to their Body fan syndrome patients. tage of extremely underweight girls (4.5%) is clearly Mass Index is 12.3%, and according to their weight 54 55 P3.05. LIFESTYLE, ENVIRONMENTAL, AND DIETARY FACTORS AFFECTING OBESITY RISK IN 10-YEAR-OLD CHILDREN AND 14-YEAR-OLD ADOLESCENTS E. Malina-Altzinger1, J. P. A. Aden2, E. Ponocny-Seliger2 [email protected] 1 Austrian Academic Institute for Clinical Nutrition, Vienna, Austria, 2 Psychological Department Sigmund Freud University Vienna, Vienna, Austria P3.06. BMI AND QUALITY OF LIFE IN ADOLESCENCE Z. Kovacovsky, B. Stetina, J. P. A. Aden, A. Bunina, E. Ponocny-Seliger [email protected] Psychological Department Sigmund Freud University Vienna, Vienna, Austria Objective: Childhood and adolescent overweight and Results: Results indicate a statistically significant obesity have increased substantially over the past two relationship between BMI and QoL in adolescents. Background: A large-scale study undertaken in Results: As part of a binary logistic regression, a com- decades, raising concerns about the biopsychosocial It shows that the higher the measured BMI the lower cooperation between the Medical University of Vien- prehensive model with a total of 18 predictors was consequences. RQ: Association between body mass the documented quality of life (girls (r=-.213; p=.009) na (MUW), Sigmund Freud University of Vienna (SFU), used to anticipate obesity. Here, the predictors of index (BMI) and health-related quality of life (QoL). and boys (r=-.211; p=.004)), resulting in e.g. little joy in and the Vienna School Supervisory Board focused on “sedentary lifestyle”, “implementation of suggestions the topic of „lifestyle, environmental, and dietary fac- in the field of sports” and “junk-food parents” pro- Research Methods and Procedures: A nationally not being able to eat what they want and suffering tors affecting obesity risk in 10-year-old children and ved to be significant. A path model was subsequently representative sample of 410 adolescents (aged 13- from being mocked about their appearance. 14-year-old adolescents „. It gave rise to the following created. It in turn supported the direct influence of 16) completed demographic and standardized tests research question: „Which familial, psychological, “sedentary lifestyle” as significant for obesity. There including the Subtest “Skala zur Lebensqualität in Discussion: The presented results underline once and lifestyle factors have significant impact on body is also a pattern of interaction between the “eating ha- Bezug auf Adipositas von Kindern und Jugendlichen” more the importance of healthy bodyweight in weight among 14-year-old adolescents?“ bits of young people” and the “food preferences of the (SLQ-Adip). The adolescent self-reported height and adolescence age. parents”, which demonstrates a reciprocal influence. weight were used to calculate the BMI (kg/m2). Statistical analysis included exploratory methods. Materials & Methods: Questionnaires were quanti- Discussion: The results imply that both lack of exer- tatively evaluated from a total n=401 female (51.7%) cise and „junk food“ consumption by parents signi- and male (48.3%) students from different schools. ficantly influence obesity rates among cohabiting A Mayring qualitative content analysis was used for adolescents. Parental nutritional choices are also as- the analysis of the two focus groups, each consisting sociated with adolescents own dietary behavior. The of 10. Our social-science approach took the form of analyses of the focus groups additionally suggest that a series of questionnaires for pupils, the Depression eating habits and body-awareness and perception are Inventory for Children and Adolescents (DIKJ) and the closely linked to the social environment. Adolescents Obesity Evaluation Questionnaire (AD-EVA). are very aware of evaluation and comparison criteria exercising, annoyance about not fitting into clothes, and see these also as a reference for self-assessment. 56 57 P3.07. LIFE MODIFICATION TREATMENT OF METABOLICSYNDROME IN SCHOOLCHILDREN WITH HIGH RISK ATHEROSCLEROTIC FAMILY HISTORY T. Szamosi, P. Goltl, A. Sragner, D. Torok, A. Szabo [email protected] 2nd Pediatric Department, Medical Faculty, Semmelweis University, Budapest, Hungary P4.01. HOW DID AN ALBINO PATIENT LOSE 148 LBS OF WEIGHT? A CASE REPORT Z. Shah1, S. Montanagh2, S. Rizvi3 [email protected] Liaquat University of Medical and Health Sciences Jamshoro, Pakistan, Thatta, Pakistan, 2Ankara University School of Medicine, Ankara, Turkey, 3R-Endocrinology, Hamilton, NJ, United States 1 Metabolic syndrome of schoolchildren with high risk the family possibilities and the lack of any smoking INTRODUCTION: Obesity is a highly prevalent and DISCUSSION: Obesity needs to be treated as any atherosclerotic family history was described by us controlled by nutritionists, physical exercise teachers yet the most neglected disease. The number of over- other complex disease. We observed Orlistat and earlier when significant parameters were detected. and medical doctors. Some patients finished the care weight and obese people reached 2.3 billion and 700 Liraglutide to be safe and effective in reducing obesi- Overweight was one of more significant parameters. period after 2 years, others finished after 3 years. Our million worldwide respectively, by the year 2015. Obe- ty. Substantial literature has emerged to show that in The investigation of the effect of 2-3 years long life results showed that after the care period the above sity is not a social disgrace but an actual disease with both Occulocutaneous albinism and Prader-Willi syn- modification treatment containing diet, physical exer- mentioned risk factors were no more detected in 615 a major genetic component to its etiology. Weight drome (the most common genetic cause of obesity) cise and no smoking advices on metabolic syndrome girls and 573 boys. Significant improvements were ob- reduction medications should be used as an adjunct the P gene is mutated on Chromosome 15. This high- of schoolchildren with high risk atherosclerotic family served in further 136 girls and 98 boys. Systolic blood to diet restriction, exercise and behavioral modifica- lights the genetic susceptibility of our albino patient background is the objective of this paper. Patients pressure and overweight have normalized earlier and tions. We hereby present a case of a morbidly obese for developing morbid obesity. were 872 girls and 715 boys aged 6-17 years having much more time was necessary for the improvement male patient with occulocutaneous albinism who has three from the following symptoms: serum triglyceri- of non alcoholic fatty liver disease. No any changes lost 148 lbs of weight. Furthermore, the report high- CONCLUSION: Obesity develops from the interplay de level above 1.1 or 1.4 mmol/L due to age, plasma were detected in 121 girls and 44 boys because of lights the genetic link between occulocutaneous alb- of both genetic and environmental factors. This case insulin level above 20 IE, serum HDL-cholesterol level the lack of cooperation or other especially endocrine inism and obesity. clearly illustrates that Orlistat and Liraglutide can be below 0.9 mmol/L, systolic blood pressure above 95 illnesses. We concluded that the life modification tre- centiles according to the age and height, body mass atment seems to be useful weapon against metabolic CASE PRESENTATION: 28-year-old male with occu- Scientific research in the genetic aspects of obesity index above 95 centiles, non alcoholic fatty liver disea- syndrome observed in schoolchildren with high risk locutaneous albinism presented with 361.8 lbs of can help develop new strategies towards its preven- se. The method contained advices about the low fat, atherosclerotic family background if the cooperation weight (BMI: 62.1) and complaint of difficulty in losing tion and treatment. low salt, no refined sugar, high fiber and high antioxi- among health services, families and their children is weight. Lab investigations showed unregulated hyper- dant diet, daily physical exercise accommodated for ensured. lipidemia and hypotestosteronemia. The patient was safe and efficient for weight loss in morbid obesity. prescribed Orlistat 120 mg. Over the period of five years, he lost 83.8 lbs. After this time, Orlistat’s effectiveness was significantly reduced. Consequently, the patient was started on Liraglutide on which he lost 64 lbs in three years. Thus, a sum of 147.8 lbs of weight was lost without any side effects of the drugs. 58 59 P4.02. TRPM8 INDUCED INCREASE IN ENERGY EXPENDITURE: ENDOCRINOLOGICAL EVIDENCES AND THERAPEUTIC IMPLICATION IN OBESITY AND ASSOCIATED COMPLICATIONS P. Khare1,2, P. Mangal3, K. K. Kondepudi1, S. S. Sharma4, K. K. Bhutani3, K. Chopra2, M. Bishnoi1 [email protected] 1 National AgriFood Biotechnology Institute (NABI), Mohali, India, 2Pharmacology division, University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh 160014, India, 3Department of Natural Products; National Institute of Pharmaceutical Education and Research (NIPER), Mohali, India, 4Department of Pharmacology and Toxicology; National Institute of Pharmaceutical Education and Research (NIPER), Mohali, India P4.03. PANCREATIC LIPASE INHIBITION: DIETARY INTERVENTION & PREVENTION OF OBESITY AND HIGH FAT DIET INDUCED METABOLIC COMPLICATIONS P. Mangal1, P. Khare2, K. K. Bhutani1 [email protected] 1 National Institute of Pharmaceutical Education and Research, SAS Nagar, Mohali, India, 2 2National Agri-Food Biotechnology Institute (NABI), S.A.S. Nagar, Mohali, India Introduction: Obesity and associated co-morbidities Results and discussion: Oroxylin A was found to in- have emerged as most challenging health problem hibit 69.86 ± 2.96% of PL enzyme at the dose of 250 Background: Obesity and its associated complications Interestingly, TRPM8 agonist also increased serum and become a leading cause of death worldwide. μg/mL. Acute dose of oroxylin A in LTT prevented the have become a global health concern. Excess energy glucagon concentration which was blocked by specific Excessive fat absorption and accumulation is the main absorption of oral lipid load and supported it’s PL intake and less physical activity have been considered and non specific TRPM8 antagonists. In agreement, cause of obesity. Pancreatic lipase (PL) enzyme plays inhibitory potential. Further, oroxylin A supplemen- as a root cause of weight gain and associated co-mor- chronic menthol administration increased liver glu- a major role in digestion of dietary fat and its absorp- tation prevented HFD induced weight gain in in vivo bidities. Energy expenditure of the body is a natural coneogenesis and reduced liver glycogen content in tion. Therefore, intervention in dietary fat absorption mouse model for obesity. Total serum cholesterol and phenomenon which can be increased to treat meta- HFD fed mouse. Importantly, these observed changes by PL enzyme inhibition of could be a preventive mo- triglyceride levels were also normalized in oroxylin A bolic disease. Aim of the present work is to explore were independent of sympathetic activity. del for obesity. supplemented group. Therefore, all the above results melastatin 8 (TRPM8) channel in enhancing energy Conclusion: Our finding suggests the role of TRPM8 Material and methods: In vitro pancreatic lipase (PL) expenditure of the body and to prevent obesity and in diversion of ingested energy from storage to ex- inhibition assay was performed to evaluate anti-obe- associated complications. penditure via TRPM8 dependent mechanisms. Hence, sity potential of oroxylin A, isolated from Oroxylum Conclusion: In vitro and in vivo effects of oroxylin A TRPM8 modulators can be developed as a preventive/ indicum bark. Further, HFD fed mouse model for obe- against fat absorption suggests the role of PL enzyme Methods: In vitro and in vivo experiments were per- therapeutic tool for obesity and associated complica- sity was used to evaluate in vivo anti-obesity potential in obesity development and give a new avenue to tre- formed in 3T3L1 cell lines and swiss albino mice res- tions. of oroxylin A. Lipid tolerance test (LTT) was performed at the obesity and concomitant diseases. supported potential of oroxylin A against obesity and the role of cold-sensing transient receptor potential to evaluate the inhibitory effect of oroxylin A on die- pectively. Acute and chronic studies were done using different agonist and antagonists of TRPM8 channel. Acknowledgement: Department of Biotechnology, tary fat absorption. Oral glucose tolerance test and Oral glucose tolerance test, histology of liver and adi- Government of India for providing research grant and other relevant experiments were also performed to pose tissue, serum hormonal levels, gene expression fellowship check potential of oroxylin A against obesity associa- and biochemical studies in different tissues were per- its associated co-morbidities. ted metabolic complications. formed. Chemical sympathetic denervation was carried out using 6OHDA. Results: Chronic menthol (prototype TRPM8 agonist) co-administration along with energy dense food in mouse prevented weight gain, insulin resistance and hepatic steatosis via increase in energy expenditure, activation of mitochondria and generation of “brite” cells in white adipose tissue. Increased energy expenditure is also shown by other TRPM8 agonist and blocked by specific and non specific TRPM8 antagonist. 60 61 P4.04. FUNCTIONAL COBIOTIC TEA AMELIORATES OBESITY ASSOCIATED COMPLICATIONS BY PREVENTING GUT DYSBACTERIOSIS IN MICE NOTES D. P. Singh1,2, K. K. Kondepudi1, K. Chopra2, M. Bishnoi1 [email protected] 1 National Agri-food Biotechnology Institute (NABI), SAS Nagar, Mohali, Punjab, India, 2 University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India Background: Palatable energy dense foods consump- Results: GTE, IMOs and their cobiotic combinations tion not only precipitates obese phenotype but also prevent HFD induced obese phenotype and associ- altered the gut microbiome diversity. It promotes me- ated metabolic complication, leaky gut, metabolic tabolic endotoxemia, ectopic fat deposition and low endotoxemia and systemic inflammation along with grade systemic inflammation. Here we evaluate the decreased beneficial microbial populations in gut. In effects of novel cobiotic concept based functional tea particular, combination of the two agents (cobiotic) (combination of green tea extract and isomalto-oligo- has shown synergistic/additive effects. saccharide) on high fat diet (HFD) induced alterations in mice via improving gut bacterial composition. Conclusion: Strategically chosen food based components when combined (functional cobiotic tea) for Design: Male Swiss albino mice were fed with HFD the systemic up-frontation against the HFD induced (58% fat kcal) for 12 weeks. Systemic adiposity and ec- alterations, could be developed as a novel class of topic fat deposition, gut lining derangement and V3- functional foods against obesity and associated com- V4 region based 16S rRNA metagenomic sequencing, plications. systemic and tissue inflammation along with gene expression analysis were done in mice supplemented with green tea extract (GTE), isomalto-oligosaccharide (IMOs) or their cobiotic combination. 62 63 AUTHOR INDEX A Aden, J. P. A.: P1.08, P1.09, P1.10, P3.04, P3.05, P3.06 Ahlström, H.: P2.02 Aiello, C.: P1.04 Akhtar, U.: P1.03 Ang, K.: P1.02 Ayers, C.: P1.03 B Bergsten, P.: P2.02 Bhutani, K. K.: P4.02, P4.03 Bishnoi, M.: P4.02, P4.04 Bjelakovic, B.: P3.02 Bunina, A.: P1.08, P1.10, P3.06 Buratta, L.: P1.04 C Cadamuro, J.: P2.02 Chiodini, E.: P1.04 Chopra, K.: P4.02, P4.04 D Dalrymple, N. O.: P1.05, P2.01 De Feo, P.: P1.04 Dieplinger, H.: 6.1 E Esposo, E.: P1.02 F Flodmark, C. E.: 5.7 Forslund, A.: P2.02 G Garib, A.: P1.05 Gattermeyer, S.: P1.10 Gianfredi, V.: P1.04 Gili, A.: P1.04 Goltl, P.: P3.07 Göpel, S.: P2.02 Grillich, L.: 5.5 H Hanauer-Mader, G.: 7.5a Hauer, R.: P1.06, P1.10 Heim, L.: P1.07 Helk, O.: 5.6, P3.04 Honma, M.: P3.01 J Jevtovic-Stoimenov, T.: P3.02 Jones Bell, M.: 3.3 Jovic, M.: P3.02 64 K Kavaric, N.: P3.02 Khare, P.: P4.02, P4.03 Kiss, A.: P3.03 Klisic, A.: P3.02 Knopf, T.: P1.10 Kocic, G.: P3.02 Koller, K.: P1.09 Kondamudi, N.: P1.03 Kondepudi, K. K.: P4.02, P4.04 Kostner, G. M.: 7.4 Kovacovsky, Z.: P1.08, P3.06 Kristinsson, H.: P2.02 Krylov, V.: P1.01 Kullberg, J.: P2.02 L Lelovics, Z.: P1.07, P3.03 Lissau, I.: 5.3 Lobstein, T.: 2.1 M Malina-Altzinger, E.: P3.05 Manell, H.: P2.02 Mangal, P.: P4.02, P4.03 Matsuura, Y.: P3.01 Mayer, A.: P1.09 Mazzeschi, C.: P1.04 Montanagh, S.: P4.01 Moreno, L. A.: 5.4 N Nakamura, M.: P3.01 Neeland, I. J.: P1.03 Nichols, S. D.: P1.05, P2.01 O Okayama, A.: P3.01 P Pachinger, O.: 5.6, 6.2, P1.10, P3.04 Paulmichl, K.: P2.02 Payne, J.: 7.5b Pecoraro, L.: 5.1 Piana, N.: P1.04 Pietrobelli, A.: 5.1 Pippi, R.: P1.04 Ponocny-Seliger, E.: P3.05, P3.06 Pöppelmeyer, C.: 5.6, P1.08, P1.09, P1.10, P3.04 Porciuncula, L. G.: P1.02 Pushkarev, N.: 1.4 R Rabmer-Koller, U.: 1.2 Ramcharitar-Bourne, A.: P1.05, P2.01 Ranucci, C.: P1.04 Reginato, E.: P1.04 Rizvi, S.: P4.01 Rocke, K. D.: P1.05, P2.01 Roillet, M.: 4.2 KEYWORD INDEX S Sakata, K.: P3.01 Saranac, L.: P3.02 Sargsyan, E.: P2.02 Sbroma, E.: P1.04 Schätzer, M.: 4.7 Schwandt, P.: 6.3 Shah, Z.: P4.01 Sharma, S. S.: P4.02 Simon, J.: 3.2 Singh, D. P.: P4.04 Sragner, A.: P3.07 Staaf, J.: P2.02 Stefanutti, C.: 7.3 Stetina, B.: P3.06 Stocker, L.: P1.10 Szabo, A.: P3.07 Szamosi, T.: P3.07 T Takahashi, S.: P3.01 Tanaka, F.: P3.01 Tanno, K.: P3.01 Tirimagni, A.: P1.04 Torok, D.: P3.07 Tschan, H.: 2.2, P1.06, P1.10 V Visscher, T. L. S.: 4.5 Vlasak, T.: P1.08 w Warschburger, P.: 2.3 Weghuber, D.: 3.4, P2.02 Widhalm, K.: 5.6, 7.1, P1.08, P1.09, P1.10, P3.04 Y Yap, K.: P1.02 Z Zsoldos, F.: P2.02 A ACS NSQIP risk score: P1.02 adolescents: P1.08, P3.06 atherosclerotic family history: P3.07 Austrian Social Security Institutions: 1.2 B body mass index: P3.06 C cardiovascular diseases: 6.1, 6.2 Caribbean: P2.01 central adiposity: P2.01 Childhood obesity: P1.04, P3.04 Cholesterol Charity: 7.5b cobiotic tea: P4.04 community based: 4.2 D Dallas Heart Study: P1.03 Denmark: 5.3 development: P1.06 diet: P1.01 dietary factors: P3.05 dietary pattern: 4.7 eating behavior: P1.08, P1.09 E Economic aspects: 3.2 EDDY: 5.6 Endocrinology: P4.02 Energy Expenditure: P4.02 EPHA: 1.4 epidemiological data: 6.1 epidemiology: 2.1 EPODE: 4.5 F familial hypercholesterolemia: 7.1 family situation: P1.09 fat absorption: P4.03 food systems: 1.4 G glucose intolerance: P2.02 gut dysbacteriosis: P4.04 H health related quality of life: P3.06 heart study: 6.3 hyperglucagonemia: P2.02 I inequality: 2.1 innovation: P1.01 Italy: 5.1 L lifestyle intervention: 5.5, P3.04 Lifestyle Regimen: 3.4 Lifestyle: P1.04, P1.07, P3.05 Lipid lowering drugs: 7.3 Lipoprotein Apheresis: 7.3 Liraglutide: P4.01 V Viasano: 4.2 Vienna: 5.6 Visceral adipose tissue: P1.03 Visceral adiposity calculator: P1.03 visceral adiposity: P2.02 M major cardiovascular event: P1.02 malnutrition: P3.03 Marfan-syndrome: P3.03 metabolic synd: P3.02, P3.07 multidisciplinary approach: P1.04 N Nationwide initiative: 4.7 New Drugs: 7.4 Nutrition: 3.4 nutrition-related knowledge: 4.7 O obesity prevention: 1.4, 3.3 Obesity: 2.1, P3.03, P3.05, P4.01, P4.02, P4.03 online: P1.01 Orlistat: P4.01 P Pancreatic lipase inhibtion: P4.03 Patient Organizations: 7.5a performance: P1.06 Physical Activity: 2.2, P1.10 physical: P1.06 Prevention: 6.2 Psychological aspects: 2.3 psychology: P1.08 R relative wall thickness: P3.02 S school based intervention: P3.04 Screening: P3.01 sodium intakes: P2.01 Spain: 5.4 Stroke: P3.01 sugar-sweetened beverages: P1.05 Sustainable: P1.07 Sweden: 5.7 T tax: P1.05 The Ecological Footprint: P1.07 Trinidad: P1.05 U uric acid: P3.02 65 WWW.OEAIE.ORG WWW.POC-VIENNA-2016.EU