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The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Glossary This glossary has been compiled by Ilona Roth with Rosa Hoekstra, Greg Pasco and Chris Barson. Term AAC action potential active but odd ADHD ADI ADOS adult-directed approach aetiology affective allele aloof amygdala AQ AS ASC ASD Asperger syndrome (AS) Definition See Augmentative and Alternative Communication. The sudden change in a neuron from the resting state to an outburst of electrical activity and back to the resting state. One of four styles of social interaction which, according to Lorna Wing, may be characteristic of adults on the autism spectrum. The adult seeks people out and tries to make contact, but their approaches tend to be inappropriate. For instance, they may talk at great length about their special interest, regardless of relevance or interest to others or come up too close to other people. (See also aloof; passive and friendly; overly formal and stilted.) See attention-deficit hyperactivity disorder. See Autism Diagnostic Interview. See Autism Diagnostic Observation Schedule. A broad term for a class of interventions in which an adult decides which skills are targeted for development or enhancement. This contrasts with child-centred approaches. (See also child-centred approach.) The study of causes of, or factors contributing to, a particular condition or disorder. Emotional. A different form or variant of a gene. One of four styles of social interaction which, according to Lorna Wing, may be characteristic of adults on the autism spectrum. The adult avoids interaction with others, remaining withdrawn and apparently unaware of the existence of others. (See also active but odd; passive and friendly; overly formal and stilted.) An almond-shaped structure in the brain located under the cerebral hemispheres. It has an important role in emotion and in regulating associated behavioural responses such as flushing, trembling or sweating when frightened. See autism-spectrum quotient. See Asperger syndrome. See autism spectrum conditions. See autism spectrum disorders. A sub-type within the autism spectrum. Asperger syndrome differs from classic autism in that communication difficulties are less pronounced (e.g. early speech milestones are normal) and IQ is in the normal or above normal range. Asperger syndrome currently has its own diagnostic criteria in DSM-IV and ICD-10. Copyright © 2010 The Open University Chapter 5 3 6 5 1 5 3 5 1 1 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term association studies attention-deficit hyperactivity disorder (ADHD) atypical autism Definition Studies that test whether a particular allele is associated with a condition or trait. Most commonly, association studies compare the frequency of a particular gene variant in cases (e.g. individuals with autism) with the frequency of this gene variant in controls. If the allele is more frequently found in cases than controls, this gene variant may constitute a risk factor for the condition. Association studies can either test the role of particular candidate genes (see also candidate genes), or scan the whole genome (see also genome-wide association study). A condition characterised by persistent and pronounced overactivity and difficulty in attending. In the DSM-IV-TR diagnostic system, this term is used interchangeably with PDD-NOS, in relation to individuals with autistic-like symptoms, who do not meet the strict criteria for autistic disorder (the DSM-IV-TR term for classic autism.) In ICD-10, atypical autism is defined more specifically in relation to atypically late onset of autistic symptoms, or the absence of one or more typical symptoms. (See also PDD-NOS.) Augmentative and A collective term for systems offered as an alternative or supplement to Alternative speech, which aim to enhance a child's communication by the use of Communication simplified vocabulary, clear structure and visual aids such as pictorial (AAC) symbols. (See also Blissymbols; PECS.) autism Neurodevelopmental condition(s) characterised by moderate to profound difficulties in communication and social interaction, and repetitive activities and interest. The term autism is used both specifically for the 'classic' form of the condition, and collectively for the spectrum of related difficulties. (See also classic autism; autism spectrum; autism spectrum disorder.) Autism Bill Draft legislation aimed at enhancing services and support for adults on the autism spectrum. In 2009 the draft proposals passed through all stages of the English parliamentary scrutiny process, and became the Autism Act 2009. This Act requires both national and regional government in England to address the serious needs of adults with autism as set out in the Bill. Autism Diagnostic An interview designed for use with the parents of children or adults who Interview (ADI) are being assessed for an autism spectrum diagnosis. The ADI comprises questions about current skills and behaviours, as well as how these behaviours were manifested at age four to five years or at any point during development. Autism Diagnostic An interactive assessment tool used in making autism spectrum Observation diagnoses. It consists of four separate modules, each comprising tasks Schedule (ADOS) designed for use with children of different ages and different levels of development and language. autism-friendly An educational environment that works with and around the special school difficulties in autism and their implications for schooling. Features include specialised staff, staff training and briefing, liaison with parents and local service providers and adaptations to the school curriculum and physical environment. autism spectrum Term first introduced by Lorna Wing to evoke variation in the expression of autistic symptoms across individuals and sub-groups. The autism spectrum is treated both as a continuum of variation between individuals, and as a collection of diagnostic sub-types, including classic autism, Asperger syndrome and PDD-NOS. Copyright © 2010 The Open University Chapter 5 4 2 7 1 9 2 2 7 1 2 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term autism spectrum conditions (ASC) Definition Term used by some professionals and some families as a more acceptable description of the autism spectrum than autism spectrum disorders. (See also autism; autism spectrum disorders; autism spectrum.) autism spectrum Term used in formal diagnosis, and by many professionals in the context disorders (ASD) of clinical practice to refer the autism spectrum and its sub-types. (See also autism; autism spectrum conditions; autism spectrum.) autism-spectrum A questionnaire-based measure of autistic-type traits devised by Simon quotient (AQ) Baron-Cohen and colleagues. A person's AQ score is derived by scoring their answers to questionnaire items concerning the way they react to other people, social situations and physical entities. Any individual may be scored on this measure. Those with an autism spectrum diagnosis are predicted to score at the extremely high end of the range of scores for a population. autistic disorder A formal term for classic autism introduced into the DSM (Diagnostic and Statistical Manual) in 1987. In the ICD diagnostic system, the corresponding term is childhood autism. (See also classic autism; childhood autism.) autistic traits Psychological or personality characteristics typically associated with autism, such as being withdrawn, emotionally detached, or obsessed with particular objects or interests. They do not necessarily mean that the person meets the diagnostic criteria for autism. (See also broader autism phenotype.) average An average is the single ‘middle’ value used to represent a set of observations or measurements. Most often the average is the mean of the measurements, calculated by adding all the measurements together and dividing by the number of measurements taken. awareness of self The capacity to be aware of one’s own inner states, experiences and characteristic ways of engaging with the world. axon The part of a neuron that sends signals to other cells (output). BAP See broader autism phenotype. bar chart A form of visual representation of data similar to a graph and widely used in scientific research. Bars set out along the horizontal axis are used to represent different groups of participants and/or different sets of observations. Bars of different heights represent different scores on a variable which is represented by the vertical axis. For instance, in the evaluation of an intervention for autism, one pair of bars may be used to represent the scores of intervention and control groups on the outcome variable before the intervention, while a second pair of bars represents the scores of these two groups after the intervention. base or unit within A separate division within a mainstream primary or secondary school a mainstream which provides some specialised classes for students with a disability school such as autism. The students join classes in the mainstream school when appropriate and are educated in the base or unit for the rest of the time. This definition refers to the UK but similar provision exists in some other countries. (See also mainstream school.) baseline period The period prior to introduction of an intervention within a multiplebaseline study. Measurements of participants' behaviour during the baseline period are compared with those made after the intervention, to evaluate whether the intervention has had any effect. (See also multiplebaseline study.) Copyright © 2010 The Open University Chapter 1 1 9 2 1 1 9 5 6 7 6 3 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term basic emotions behaviour modification behavioural interventions biological perspective blind rating Blissymbols block design bonding broader autism phenotype (BAP) bullying calendrical calculation CAMHS candidate gene case history Definition Usually applied to six emotions – happiness, sadness, anger, fear, disgust and surprise. These emotions are said to evoke characteristic facial expressions that are universally expressed and recognised across cultures. Research studies differ as to whether people on the autism spectrum have difficulty recognising basic emotions. (See also complex emotions.) The application of principles of learning and conditioning to influence or improve a person's behaviour, by eradicating maladaptive behaviours and learning new ones. Based on the work of B.F.Skinner, and pioneered in the autism field by Ivar Lovaas. A broad term for the class of interventions that employ principles of learning such as operant conditioning to bring about changes in a child or adult's behaviour. Behaviour deemed desirable is rewarded or reinforced, while unwanted behaviour is reduced or extinguished. These approaches are adult-directed. (See also adult-directed approach; behaviour modification; operant conditioning.) Seeking to understand and explain aspects of human behaviour in terms of biological concepts and theories. A procedure to ensure that when a researcher evaluates or interprets observed behaviour, their judgements are not influenced by expectations about how the individuals being observed should behave. In autism research, for instance, the researcher making the observations may not be told whether or not the individuals being observed have autism diagnoses. A form of Alternative and Augmentative Communication employing a system of pictorial symbols, and used to help children with poor verbal communication. Each symbol represents a concept and can be combined with others to represent further concepts. (See also Augmentative and Alternative Communication.) A sub-test within a non-verbal intelligence (IQ) test, in which the participant is asked to arrange some coloured blocks to copy a geometric pattern. (See also intelligence tests.) The development of a close emotional relationship between family members or friends. Bonding is a mutual, interactive process involving reciprocity or 'give and take'. In typical development, bonding between infant and mother is thought to develop from birth onwards. (See also reciprocity.) Milder manifestations of traits characteristic for autism in relatives of people with autism. Verbal or physical intimidation or maltreatment of somebody weaker or in a more vulnerable situation. Bullying causes fear, distress and often has long-term effects. The highly specialised ability to work out what day of the week it was on a randomly chosen and distant date such as 20 January 1809. (See also savant syndrome.) See Child and Adolescent Mental Health Service. A gene whose function, or location on a chromosome, suggests that it might be associated with a condition or disorder. A detailed account of facts relevant to the development of an individual's problems or situation. The material is structured and organised as an informative record for use by a psychiatrist, psychologist, social worker etc. Copyright © 2010 The Open University Chapter 3 1 6 3 3 7 3 3 5 7 3 5 2 4 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term case study CDC cell body central coherence cerebellum cerebral cortex cerebral hemispheres CFCS challenging behaviours CHAT Checklist for Autism in Toddlers (CHAT) chelation Child and Adolescent Mental Health Service (CAMHS) Child and Family Consultation Service (CFCS) child-centred approach Child Development Centre (CDC) Definition In-depth observation and description of the specific characteristics of a selected individual. Pooling of case study material across individuals may permit identification of general features. The method is used by clinical practitioners, and in some forms of research. See Child Development Centre. The main part of a neuron where the information is processed. (See also axon; dendrite.) Focusing on overall form and meaning rather than fine detail when processing information from the environment. This has been considered as both a perceptual phenomenon (seeing whole figures, or hearing whole patterns of sounds) and a conceptual phenomenon (processing the meaning or gist from spoken or written language). A key theory of autism suggests that central coherence is lacking in people on the autism spectrum, though this is now proposed as a cognitive style rather than a fixed deficit in processing information. (See also weak central coherence; cognitive style.) A structure in the brain located under the occipital lobe of the cortex. It plays an important role in the control of motor movements, posture and balance. It is particularly important in movements with a social function, such as gestures and expression. The outer layer of the brain. The brain is divided into two approximately symmetrical halves, referred to as the left and the right cerebral hemispheres. See Child and Family Consultation Service. Behaviour of such intensity, frequency or duration that the physical safety of the person or others is placed in serious jeopardy and/or access to and use of ordinary community facilities is impeded. See Checklist for Autism in Toddlers. One of the first tools developed for the screening of autism in preschool children. It was originally designed to be administered at a routine developmental assessment of children at 18 months of age, carried out by health visitors or GPs. Key items include questions about pointing, shared attention and pretend play. An intervention which involves injecting people with autism with agents that reduce the levels of heavy metals such as lead and mercury. Considered very hazardous. A service within the National Health Service in the UK, which provides assessment and treatment for young people with mental health and psychiatric difficulties. A UK service to which children and adolescents, and their family members, may be referred if there are problems with behaviour or development at school or at home. A broad term for the class of interventions which involve following the child's own interests and motivation as a means of encouraging interaction and learning. This contrasts with adult-directed approaches. (See also adult-directed approaches.) Child Development Centres carry out thorough assessments of children who appear to have developmental problems. Social Communication Clinics within CDCs specialise in assessing children with language and communication difficulties. (See also Social Communication Clinic.) Copyright © 2010 The Open University Chapter 1 5 4 5 5 5 7 2 6 2 2 6 2 5 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term childhood autism Definition A formal term for classic autism within the ICD diagnostic system. In the DSM diagnostic system, the corresponding term is autistic disorder. (See also classic autism; autistic disorder.) chromosome Structural unit in all living cells, composed of long strands of DNA on which genes are found. (See also DNA; X and Y chromosomes.) chronological age A person's age in years and months. In psychological tests, a person's chronological age is often considered alongside their mental age. classic autism The term classic autism is often used to differentiate the prototypical form of autism, with full expression of the characteristic triad of impairments, from other sub-types of autism such as Asperger syndrome. (See also autism; Asperger syndrome.) clinical A psychologist with specialist qualifications and experience in the use of psychologist psychological methods and theories to help people of all ages who have learning disabilities or mental health problems, such as depression or anxiety. Unlike psychiatrists, clinical psychologists do not have to be medically qualified. co-morbidity A medical term for the presence of one or more conditions or disorders alongside a primary condition. In autism, epilepsy is a common co-morbid condition. codes Words, phrases or symbols that provide concise summaries of information. In psychological research coding (the use of codes) is employed to provide informative short-hand headings for rich data such as spontaneous behaviour, spoken or written language. cognition The mental processes involved in thinking, understanding and using language, planning activities and solving problems. cognitive style A strategy or preference affecting the way a person processes information, emphasising that there is scope for the individual to control what they attend to and select. The idea that attention to detail or weak central coherence is a cognitive style in autism contrasts with the earlier claim that this is a fixed and immutable bias. (See also central coherence; weak central coherence.) complex emotions Emotions such as embarrassment, shame and pride. Typically these emotions cannot be recognised from a person's facial expression alone, but require the integration of other sources of information, especially the context in which the emotion has arisen. For instance, to recognise that a person is feeling embarrassed, it may be necessary to know that they have done something that would cause them to feel this way (See also basic emotions.) comprehensive Interventions, also known as ‘integrated approaches’ that aim to help and approaches support individuals on the autism spectrum across many key aspects of functioning, including learning, behaviour, social and communication needs. These approaches are called comprehensive because they address a broad range of skills and deficits, and also because they may be used in different settings (at home, school, in respite services and other locations), as well as across the lifetime of the individual. Examples are TEACCH, Lovaas and the Son-Rise programme. concordance The occurrence of the same (or similar) condition, characteristic or trait in both members of a pair of twins. concordance rate The proportion or percentage of cases in which both members of a pair of twins show the same (or similar) condition, characteristic or trait. Copyright © 2010 The Open University Chapter 2 5 3 1 2 1 3 1 4 3 6 1 1 6 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term confounding factor Definition An extraneous variable in a research study or clinical evaluation that varies between groups or conditions in such a way that the influences responsible for observed effects on outcomes are unclear. For instance, if participants receiving an intervention are high-functioning, while those not receiving the intervention are low-functioning, differences in outcomes may be due to this rather than to the effects of the intervention. connectivity The connections between different parts of the brain and how well they communicate. control group A group of participants in an experiment or other systematic study which differs from the experimental group in not having a characteristic of interest, or not receiving a 'treatment' which the experimental group receives. For instance, the control group may be typically developing individuals, while the experimental group has autism spectrum diagnoses; alternatively the control group and experimental group may both have similar characteristics but be presented with different stimuli or task conditions in an experiment. (See also experiment; experimental group.) core deficit Models that assume that a single underlying problem or deficit accounts models for the wide range of behavioural and psychological difficulties that are observed in autism. correlations A correlation is a statistical relationship between two variables. A correlation of 1 means that the two variables are perfectly correlated, a correlation of 0 means that the two variables bear no relationship at all. cortex See cerebral cortex. cross-sectional Studies that collect information in individuals at only a single point in time. studies These contrast with longitudinal studies in which individuals are followed over time to track their development. (See also longitudinal studies.) Daily Life Therapy A whole school approach to children with autism originally developed in Japan, and now also practised in Higashi schools in the UK and USA. Educational goals include independence in daily life skills, improved awareness of body and behaviour and group participation. (See also whole school approach.) de novo mutation Literally a 'new' mutation: a new genetic variant that neither parent possessed nor transmitted which is expressed for the first time in the offspring. deletion A type of genetic mutation in which a sequence of DNA has been lost. A deletion is the opposite of a duplication. (See also duplication; mutation.) dendrites The parts of a neuron that receive signals from other neurons (input.) deoxyribonucleic See DNA. acid Department for A UK government department with responsibility for all issues affecting Education and people up to the age of 19 including child protection and education. In Skills (DfES) England this is now the Department for Children, Schools and Families (DCSF.) dependent A variable which is observed to vary under the influence of another variable variable. In experimental research, the experimenter manipulates or changes one variable (the independent variable) in order to observe the effects on another variable (the dependent variable.) For instance, the experimenter might observe how different characteristics between an experimental and a control group influence the scores achieved by the two groups on a memory test. (See also outcome measure; variable.) Copyright © 2010 The Open University Chapter 6 5 1 4 3 5 7 5 5 5 7 6 7 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term Developmental, Dimensional and Diagnostic interview (3Di) Developmental, Individualdifference, Relationshipbased (DIR) developmentalpragmatic approaches developmental trajectory DfES 3Di Diagnostic and Statistical Manual of Mental Disorders (DSM) diagnostic criteria Diagnostic Interview for Social and Communication Disorders (DISCO) DIR DISCO discrete trial procedures Definition An interview designed for use with the parents of children or adults who are being assessed for an autism spectrum diagnosis. The format of the 3Di is similar in structure to the ADI, but uses computer analysis of the responses in an attempt to reduce the time burden on clinicians. Like the DISCO, the 3Di offers a dimensional framework, allowing for graded evaluation of how far the individual matches the criteria for a pervasive developmental disorder. (See also ADI; DISCO.) A developmental-pragmatic intervention, intensely child-centred, and based on the idea that children on the spectrum do not connect social and emotional knowledge to their developing motor and symbolic skills. The intervention involves following and imitating the child's actions using sensorimotor techniques such as swinging or physical pressure, and presenting the child with challenges to be overcome by gestures or verbal communications. Also known as Floortime. (See also child-centred approach; developmental-pragmatic approaches.) A class of interventions, also known as social pragmatic approaches, based upon an understanding of typical developmental processes, particularly in relation to early social communication and interaction skills. A term for the developmental sequence. This emphasises two facets of typical development: (1) There is a characteristic sequence of 'milestones' such as crawling, sitting up and walking. (2) Early developmental skills such as pointing and looking are thought to lay the foundations for later more sophisticated skills such as play with siblings, friendships with peers, or the complex relationships of the teenage years and adulthood. The idea of an atypical developmental trajectory is an important concept in work on autism. See Department for Education and Skills. See Developmental, Dimensional and Diagnostic interview. The American Psychiatric Association's formal system for the classification and diagnosis of psychiatric conditions, mental health problems and psychological disability. The diagnostic criteria and guidelines are revised periodically, the current version, DSM-IV-TR, being shortly due for replacement by DSM-V. (See also diagnostic criteria; ICD.) Formal descriptions of medical and psychiatric conditions, used in making diagnoses. The criteria comprise a list of symptoms or features that an individual must have for a condition or problem to be diagnosed, and in some cases specify additional symptoms that should not be present. An interview designed for use with the parents of children or adults who are being assessed for an autism spectrum diagnosis. The interview offers a 'dimensional' framework, allowing for ‘graded’ evaluation of how far an individual matches the criteria for a pervasive developmental disorder, as defined in the ICD and DSM systems. (See also ADI; 3Di.) See Developmental, Individual-difference, Relationship-based. See Diagnostic Interview for Social and Communication Disorders Procedures originating within the operant conditioning framework, and employed within the Lovaas approach to intervention. They involve analysing a child’s behaviour into components that can be individually tackled using operant conditioning and reinforcement. (See also operant conditioning; Lovaas approach.) Copyright © 2010 The Open University Chapter 2 6 6 3 1 1 2 6 8 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term dizygotic (DZ) twins DNA (deoxyribonucleic acid) Down syndrome DSM duplications E-S theory EarlyBird echolalia eclectic approach ecological validity EEG EF effectiveness study efficacy study electroencephalo graphy (EEG) embedded figures test empathising quotient (EQ) Definition Twins that are the product of two different eggs that were fertilised by two different sperm cells. Dizygotic twins are genetically non-identical and can therefore be of same sex or opposite sex. They are genetically no more similar than non-twin siblings. (See also identical twins; twin method.) Molecules in the cell that contain the instructions necessary in the development and functioning of all living organisms. Sections of DNA form genes. A disorder caused by chromosome abnormality and usually involves a degree of intellectual disability, together with characteristic physical features, and sometimes medical problems. See Diagnostic and Statistical Manual of Mental Disorders. A type of genetic mutation in which a sequence of DNA is present in two or more copies on the chromosome. A duplication is the opposite of a deletion. (See also deletion; mutation.) See empathising-systemising (E-S) theory. A three-month education programme providing support and encouragement and promoting good practice for parents of newly diagnosed (preschool) children on the autism spectrum, run by the National Autistic Society. (See also Hanen.) The repetition of words, phrases or sentences just spoken by others, in a 'parrot-like' fashion. Echolalia is common in individuals on the autism spectrum, and also occurs in conditions such as schizophrenia and Tourette's syndrome. In autism, the repetition may be immediate or delayed. The use of a combination of different interventions to support people with autism in real-life settings such as the classroom or adult service. The extent to which an experiment or other research task mirrors a reallife situation. Ecological validity can refer to features such as the type of stimuli used, the responses that participants are required to make, or the context in which the study is conducted. See electroencephalography. See executive function. An evaluation of an intervention carried out under ‘real-world’ or everyday conditions, e.g. the intervention is delivered by parents in the child's home environment. An evaluation of an intervention carried out under ideal conditions, e.g. by highly trained specialists. A procedure used in research and clinical practice, in which several electrodes are attached to the scalp of the participant. These electrodes measure the electrical activity that is produced by the neurons in the brain. A test of the capacity to identify an individual component or shape from a pattern in which it is embedded. A questionnaire devised by Baron-Cohen and colleagues to measure levels of empathising or empathy. The assumption underlying the test is that empathising is a dimensional or continuous trait. Each member of a population can receive a low, high or average score on empathising; on average, males are predicted to score lower than females; people on the autism spectrum are predicted to score very low on empathising. (See also empathising-systemising theory; systemising quotient.) Copyright © 2010 The Open University Chapter 5 5 3 5 8 1 6 4 6 6 5 4 4 9 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term empathisingsystemising (E-S) theory empathy epidemiological study epilepsy EQ evidence base evidence-based practice excitatory exclusion executive function (EF) experiment Definition A theory formulated by Baron-Cohen, which proposes that autism is characterised by poor empathising ability, combined with enhanced systemising. (See also empathy; empathising quotient; systemising; systemising quotient.) Broadly defined as the capacity to understand and 'enter into' another person's emotions. Different researchers employ this term in related but slightly different ways. For Hobson, empathy involves a direct and intuitive feeling 'for and with' another person, which will typically include feeling the same emotion the other person feels. For Baron-Cohen, empathy, or empathising, involves two separable components – cognitive: recognising what someone else is feeling and affective: experiencing an appropriate reaction, e.g. feeling sad yourself or trying to comfort someone. Research suggests that empathy is impaired in autism. Study of the factors determining and influencing the frequency and distribution of disease, injury and other health-related events and their causes in a defined human population. Estimating the prevalence of the condition in question is often an important part of an epidemiological study. (See also prevalence.) A group of neurological disorders characterised by recurrent seizures, which reflect abnormal or excessive activity in one or more brain area. Seizures may be accompanied by uncontrollable jerking and temporary loss of consciousness. See empathising quotient. The quantity and quality of available evidence concerning the efficacy and/or effectiveness of an intervention. (See also evidence-based practice; efficacy study; effectiveness study.) The approach which emphasises that interventions and other clinical applications must be based on sound empirical research findings, i.e. there must be a good evidence base for them. The approach is widely advocated in clinical psychology. (See also evidence base.) When a neurotransmitter induces an action potential in a postsynaptic neuron or increases the existing activity of this neuron, the effect is said to be excitatory. An order that temporarily or permanently excludes a child from their usual school. A collective term for cognitive capacities such as planning, flexibly transferring attention from one activity to another, inhibiting inappropriate responses in order to stay 'on task', and generating new activities and ideas. (See also planning; mental flexibility; inhibition; generativity.) Method used throughout the natural and social sciences to gather evidence relevant to explaining particular phenomena. Typically an experiment involves (a) testing a hypothesis by systematically manipulating (varying) one variable, known as the independent variable, and measuring the effects on another variable, known as the dependent variable; (b) controlling all sources of variation except the ones under study, so that the effects of the first variable on the second can be clearly inferred. Psychological experiments frequently involve comparing one group of participants (the experimental group) against a control group. (See also dependent variable; hypothesis; variable.) Copyright © 2010 The Open University Chapter 4 3 1 1 6 6 5 7 4 1 10 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term experimental group expressive language extreme male brain theory false belief test falsifiable firing Floortime fMRI follow-up studies fragile X syndrome Freudian psychoanalysis frontal lobe full-scale IQ Definition A group of participants in an experiment or other systematic study, defined in terms of a characteristic of interest and/or a 'treatment' that distinguishes this group from the control group. For instance, participants in the experimental group may have autism spectrum diagnoses, while participants in the control group do not; alternatively both experimental group and control group may have similar characteristics but be presented with different stimuli or task conditions in an experiment. (See also experiment; control group.) Language that a person produces, typically in written or spoken form. Difficulty with expressive language means that the person has delay and/or difficulty in producing language. The person's spoken language will be sparse in vocabulary and/or grammatically and syntactically incorrect. The person is likely to have difficulty in putting thoughts into words, and in using language appropriately in different settings. Difficulty with expressive language is common on the autism spectrum, and is often accompanied by receptive language difficulty. (See also receptive language.) An extension of Baron-Cohen's empathising-systemising theory which claims that the cognitive profile in autism, characterised by an unusually high score on systemising and an unusually low score on empathising, is an accentuated version of the typical profile for males. This has led Baron-Cohen to link autism to high levels of the 'male' hormone, testosterone. An experimental test of the ability to understand that another person's belief about a situation may be false, that is, different from reality. Used as test of theory of mind in people on the autism spectrum. The classic false belief test for children is known as Sally-Anne. Refers to the need for a theory to be formulated such that it is in principle possible to prove that it is incorrect. A theory which is not falsifiable is likely to have little explanatory power. Neuronal signalling via the axons of these cells Another term for Developmental, Individual-difference, Relationshipbased (DIR). See definition for that term. See functional magnetic resonance imaging. Studies in which the characteristics of a group of individuals are tracked over an extended period of time, in order to evaluate progress and development. For instance, the symptoms and intellectual functioning of a group of autistic children may be re-assessed in adulthood. A genetic disease syndrome caused by an expansion of a sequence of the FMR1 gene located on the X chromosome. It is the second most common cause of intellectual disability in males. A theoretical and therapeutic framework developed by Sigmund Freud, considered the founding father of psychoanalysis. A lobe of the cerebral cortex. It is concerned with articulation of speech, movement, emotions and problem solving. It is also important for executive functions, such as reasoning and planning. Called 'frontal' because it is located towards the front of the brain. The overall score that a person achieves on an intelligence test, reflecting a mean of their verbal and performance IQ. (See also intelligence quotient.) Copyright © 2010 The Open University Chapter 1 3 4 4 4 5 1 5 1 5 3 11 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term functional magnetic resonance imaging (fMRI) fusiform gyrus GABA (gammaaminobutyric acid) generalisation generativity genes genetic genetic counsellors/ counselling genetic heterogeneity genome-wide association study glutamate grammar graph grey matter Definition A variant of MRI scanning that offers insight into the brain at work. fMRI can give very detailed information about the location of the brain activity, but is limited to changes that take place over about a second. (See also imaging; magnetic resonance imaging.) A part of the brain in the temporal lobe, known to play an essential role in recognising faces and for differentiating between different faces, objects and emotions. A neurotransmitter that plays an important role in early brain development. It primarily has an inhibitory effect in the brain. Chapter 5 The carrying over of a skill or response to a different situation or context, e.g. one that is more complex, more ‘real-life’ or involves interacting with different people. The capacity to generate new activities and ideas. A component of executive function. (See also executive function.) Genes are small sections of very long molecules of deoxyribonucleic acid (DNA.) Genes contain the codes for proteins, which are in turn necessary in the development and functioning of all living organisms. Refers to the influence of genes on a condition or trait (physical, psychological, etc.) An educational counselling process for individuals and families who have a genetic condition or disorder or who are at risk for such a condition/disorder. Genetic counselling is designed to provide patients and their families with information about their condition and about the risks that further offspring may also be at risk of developing the disorder. Given the current state of knowledge about genetic factors in autism, genetic counselling cannot provide a definitive risk assessment. The notion that a single condition or disorder may be caused by different genes. Autism is genetically heterogeneous: the set of genes involved in causing autism in one individual is likely to be different from the set of genes involved in autism in another individual. Autism is also polygenic: in a given individual, the condition is likely to be influenced by the combined effects of multiple genes. (See also polygenic.) An association study that systematically assesses DNA variation throughout the genome. A neurotransmitter found throughout the brain. Glutamate has an excitatory effect on the postsynaptic neuron and is thought to be crucial in neural plasticity and in cognitive functions such as learning and memory. A set of rules that govern the composition of sentences, phrases, and words in a given language. Each language (English, French, etc.) has its own grammar. (See also syntax.) A visual diagram showing the relationship between two or more variables (for instance height and age) which are plotted against each other. Typically, the basic framework of a graph is a vertical line or axis (the 'y'axis) crossing or joining a horizontal line (the 'x'-axis) to form an L shape or a cross. The y-axis shows the possible values of one variable, while the x-axis shows the possible values of the other variable. Observations of the relationship between the two variables are plotted as the coordinates of the two sets of values. Refers to the cortical regions of the brain. Because the cortex has such a high density of cell bodies, it has a relatively dark colour. (See also white matter.) 6 Copyright © 2010 The Open University 5 5 4 5 1 8 5 5 5 3 3 5 12 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term gyrus Hanen health visitor heritability HFA high-functioning autism (HFA) horizontal axis hormone human genome human primacy hypothesis ICD idiopathic IEP imaging incidental teaching inclusion Definition The smooth areas of the cortex between foldings, which form a crown, are termed gyri (singular term is gyrus.) An education programme developed in Canada in which parents and other care-givers of children on the autism spectrum learn techniques for promoting children’s communication and language development during everyday activities. (See also EarlyBird.) A qualified nurse or midwife, who works in the community, providing advice and help on health matters, especially to parents with young children. The extent to which a condition or feature can be attributed to genetic influences. If a condition is highly heritable it means that parents are likely to pass on the condition to their child(ren) through their genes. See high-functioning autism. A term used by some specialists to describe cases of autism where the individuals’ full-scale IQ scores are above 70. HFA is not a formal diagnostic category: the term is used in everyday situations and research. The difference, if any, between HFA and Asperger syndrome is a matter of debate. (See also low-functioning autism; Asperger syndrome.) The horizontal dimension of a graph. Also known as the 'x'-axis. (See also graph.) Type of chemical that has a major role in transmitting signals around the body. All the hereditary information carried within each human cell. Refers to the observation that from birth onwards infants engage with other humans in ways which are distinct from how they engage with nonhumans and the physical world. A proposed explanation for an observed phenomenon, which is tested using the experimental method. Typically the hypothesis will predict the outcome that will occur if one variable has an effect on, or relationship to, another. (See also experiment; variable.) See International Classification of Diseases. A term used to describe conditions or disorders which are of unknown cause. See Individual Education Plan. Collective name given to any of a number of techniques that allow a computer-generated image of a living brain or other internal body structure to be produced. (See also fMRI; MEG; MRI.) A naturalistic intervention harnessing naturally occurring interactions between an adult and a child in contexts such as free play. These opportunities are used by the adult to transmit information or give the child practice in developing a skill. The aspiration that all children, regardless of disability, religion, ethnic group or other differences, should have the opportunity to learn, achieve and participate fully in the life of their school. In relation to disabilities such as autism, inclusion is quite often interpreted to mean the right of a child to be educated in their own community, alongside other children of the same age without disabilities – thus in the mainstream. However, this environment may not necessarily provide the most inclusive experience for a child on the autism spectrum. Copyright © 2010 The Open University Chapter 5 8 2 5 2 3 5 5 4 1 5 7 5 6 7 13 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term independent school Individual Education Plan (IEP) inhibition inhibitory innate integrated approaches intellectual disability intelligence quotient (IQ) intelligence tests (IQ tests) inter-rater reliability International Classification of Diseases (ICD) intervention group interventions intonation Definition A mainstream, special or residential school, also known as a nonmaintained school, which is not funded by the local authority and is therefore fee-paying. Parents may opt to educate a child at their own expense, or seek local authority funding to support their child's education. This definition refers to the UK but similar provision exists in some other countries. (See also mainstream school; special school; residential school.) A plan designed to support and enhance the educational progress of an individual child by specifying short-term targets and strategies, tailored to the specific educational needs of the child. Suppressing or inhibiting inappropriate responses in order to stay 'on task'. A component of executive function. (See also executive function.) When a neurotransmitter decreases the level of existing activity in a postsynaptic neuron, the effect is said to be inhibitory. Characteristics that are present before or at birth. An alternative term for comprehensive interventions. See definition for that term. Marked difficulty in tasks involving thinking, logical reasoning and problem solving. Usually defined as an IQ score less than 70. The score that a person achieves on an intelligence test standardised by comparison with the scores of other individuals within the same age range. Some intelligence tests include a separate verbal and performance intelligence quotient. In this case, their full-scale intelligence quotient is the mean of these two. Standardised tests used to provide an objective measure of a person's intellectual abilities, as compared with the average for the population. The person receives an intelligence quotient (IQ score) based on their performance on tests of intellectual ability including acquisition of concepts and information, problem solving and logical reasoning. One widely used system includes verbal tests such as vocabulary, comprehension and general knowledge, and performance or non-verbal tests, such as block design and picture completion. (See also block design; picture completion; intelligence quotient.) An estimate of the extent to which two or more researchers, working independently of one another, agree in the way they rate or interpret observed behaviour. Inter-rater reliability is an important step in quantitative observational research. (See also observational method; quantitative method.) The World Health Organisation's formal system for the classification and diagnosis of physical disorders, psychiatric conditions, mental health problems and psychological disability. The diagnostic criteria and guidelines are revised periodically; the current version, ICD-10, is due for replacement in 2014. (See also diagnostic criteria; DSM.) The group receiving an intervention in a study evaluating its efficacy or effectiveness. The intervention group is equivalent to the experimental group in a research study, and is compared with a control group which does not receive the intervention. Procedures for supporting and improving the health and functioning of someone with a clinical problem such as autism. The characteristic rise and fall of speech, which plays a role in communication, and may be atypical in people on the autism spectrum. Copyright © 2010 The Open University Chapter 7 7 4 5 1 1 3 3 3 1 6 1 2 14 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term intuitive physics intuitive understanding IQ ironic joint attention language Learning Support Assistants LFA linkage analysis local authorities longitudinal studies Lovaas approach low-functioning autism (LFA) MA MAA Definition Everyday insights into the forces governing physical objects, the implication being that these insights are acquired relatively spontaneously, rather than being the result of education. A test of intuitive physics devised by Baron-Cohen and colleagues has been used to demonstrate that people on the autism spectrum may be good systemisers, i.e. highly attuned to physical systems. (See also systemising; empathising-systemising theory.) A direct or spontaneous understanding of other people, which does not depend on conscious processes of working out their thoughts and feelings. (See also empathy.) See intelligence quotient. Irony is the use of an expression or phrase to mean something different from or opposite to what it normally means. Being ironic means speaking with irony. The phenomenon in which one person coordinates or shares their attention with another, in order to focus on the same object or event. Joint attention emerges in typically developing children by about 12 months of age. Children later receiving autism spectrum diagnoses show poor joint attention skills. (See also protodeclarative pointing.) Narrowly defined, language is a system of sounds, signs or written items (letters, word fragments and words), together with rules for combining these elements in ways that convey meaning to others who share a knowledge of this language. Learning support staff, also known as Teaching Assistants, who work alongside teachers in the classroom, helping students progress with their learning. In some cases they specialise in areas such as literacy, numeracy, special educational needs, music, English as an additional language, and the creative arts. See low-functioning autism. A technique that detects linkage between DNA markers (landmarks in the DNA) and a condition or a trait. The technique is used to get an idea of what region of which chromosomes may be involved in the risk for a condition such as autism. Regional government bodies in the UK with responsibilities in areas such as education, health and social services. Studies involving repeated observations over an extended period of time. Longitudinal studies are often employed to follow the development of individuals over time. These studies contrast with cross-sectional studies, in which data are collected in each individual at one time point only. (See also cross-sectional studies.) A comprehensive behavioural intervention for children on the autism spectrum developed by Ivar Lovaas and colleagues. The technique employs reinforcement to modify children's behaviour through operant conditioning. The technique typically targets language development, social interaction and school integration skills. (See also behavioural interventions; comprehensive or integrated approaches; operant conditioning; reinforcement.) A term used by some specialists to describe cases of autism where the individuals' full-scale IQ score is below 70, i.e. in the disabled range. LFA is not a formal diagnostic category; the term is used in everyday situations, and in research. (See also high-functioning autism.) See mental age. See multi-agency assessment. Copyright © 2010 The Open University Chapter 4 4 3 2 3 7 5 2 5 6 2 15 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term Definition magnetic A readily available and widely used imaging technique that reveals the resonance structural anatomy of the brain. (See also imaging.) imaging (MRI) magnetoencepha- A method that measures brain activity directly. MEG exploits the fact that lography (MEG) active neurons induce weak magnetic fields, so when a group of neurons is collectively active, they produce a signal that is strong enough to be measured. MEG detects the brain’s electrical activity during a task directly (without much time delay), but it is less precise than fMRI in determining the exact location of brain activity. (See also imaging.) mainstream The type of primary or secondary school that is provided for the majority school of children. While some children with disabilities such as autism do attend mainstream school, the curriculum and environment is not specifically tailored to children with special needs. Some need a more specialised education environment and are educated in different schools. This definition refers to education systems in the UK but similar provision exists in some other countries. (See also special school; residential school.) mean The most commonly used type of average, calculated by adding a set of measurements together, and dividing by the number of measurements made. median A type of average used in statistics and research reports. The median is calculated by arranging a set of values in order of magnitude and identifying the middle value. If two values are in the middle the median is the mean of these two values. medical model The approach that interprets conditions such as autism as disabling disorders akin to physical diseases, and therefore requiring clinical diagnosis and treatment, with the aim of rendering the person with the disorder as near to 'normality' as possible. MEG See magnetoencephalography. mental age (MA) A way of expressing a child's level of intellectual functioning in terms of the age of children whose performance on IQ tests matches this level. For instance, a child with a chronological age of 10 years, who has an IQ score equivalent to the average of a group of 14 year-olds, has a mental age of 14 years. A child with an IQ score equivalent to the average of a group of 7 year-olds has a mental age of 7 years. Mental age is sometimes a useful concept in considering intellectual disability. (See also chronological age; IQ.) mental flexibility Readily shifting one's attention from one completed activity or task to another quite different one. A component of executive function. (See also executive function.) mental states A collective term for the processes, including thinking, believing and feeling, which characterise human thought. mentalising Similar to mind-reading mentalising means the act of thinking about mental states. (See also theory of mind; mind-reading.) metaphors A metaphor is a word or phrase applied to a concept with which it has no literal relationship. milieu Another term for naturalistic approaches. See definition for that term. approaches mind-reading The term has a similar meaning to theory of mind, but emphasises that mental state understanding in everyday life involves more than the formal theory of mind skills tested with false belief tasks.(See also theory of mind; mentalising.) Copyright © 2010 The Open University Chapter 5 5 7 1 8 9 3 4 4 4 3 6 4 16 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term mirroring MMR (measles, mumps and rubella) vaccine modality model molecular genetics monozygotic (MZ) twins motor behaviour MRI multi-agency assessment (MAA) multi-modal emotion recognition multiple-baseline study multiple factor model multiplex autism family Definition Broadly defined as the phenomenon in which one individual echoes or copies the behaviour of another with whom they are in social interaction. In emotional mirroring, one individual experiences the same emotion as another with whom they are interacting. This is also known as empathy. Some scientists have suggested that the capacity for different forms of mirroring depends on neurons in the brain which are activated not only when one individual does something or feels something, but when that individual simply observes another person's behaviour. Thus watching someone dancing is reported to activate neurons in the areas of the brain involved in motor activity. (See also empathy.) A combined vaccine administered to children (initially at 12–15 months) to protect them against measles, mumps and rubella. The vaccine was linked to autism in 1998, in a controversial research paper by Wakefield and colleagues. The paper is now discredited and subsequent research indicates no link. In relation to sensation and perception, modality means a specific channel or dimension of input, such as sound, touch or taste. A form of theoretical explanation, often specifying mechanisms or processes depicted in visual form such as a chart. In psychological research on autism, the term model often means a broad approach or conceptualisation embracing several related theories. (See also theory.) The understanding of genes at the level of the molecules involved. Chapter 3 Twins derived from a single fertilised egg that divided and separated in an early stage of pregnancy. Monozygotic twins, also known as identical twins, are genetically identical and are therefore always of the same sex. (See also twin method.) Patterns of movement which depend on the coordinated activity of muscles, joints and other anatomical structures. See magnetic resonance imaging. A system of good practice advocated for use in assessing children or adults for conditions such as autism. The assessment involves close collaboration and joint working arrangements between different agencies and specialists, such as educational psychologist, speech and language therapist, social worker, medical doctor, to facilitate an in-depth picture of all aspects of the individual's difficulties, and family support needs. The integration of facial expression and voice with other sources of information including gesture, body posture and context. 5 A study that evaluates the effect of an intervention on a small number of participants, in which a baseline (pre-intervention) period is followed by an intervention commencing at a different time for each participant. (See also baseline period.) Model that assumes that separate influences, working alongside one another, result in the difficulties in communication, social interaction and inflexibility of thought and behaviour observed in autism. A family in which more than one child/family member is on the autism spectrum. The existence of a substantial number of such families provides strong evidence that genetic factors play a role in causing autism. Without such genetic vulnerability the probability of autism occurring in more than one member of the same family would be very low. Copyright © 2010 The Open University 1 3 4 1 3 2 3 6 4 8 17 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term mutation mutism myelin NAP-C NAS National Adult Autism Strategy National Autism Plan for Children (NAP-C) National Autistic Society (NAS) naturalistic naturalistic approaches nervous system neural plasticity neuroanatomy neurobiology neuron neurotransmitter neurotypical (NT) non-maintained schools non-verbal communication Definition A change in the sequence of units of the DNA. Examples of mutations include duplications and deletions of DNA sequences. (See also deletions; duplications.) Mutism, meaning absence of speech, is observed in some individuals on the autism spectrum, and is usually assumed to reflect an inability to communicate using speech. In some individuals mutism may reflect the avoidance of speech due to extreme anxiety. A fatty white substance that encases axons. It provides an insulation layer and thereby increases the speed at which a signal can travel along the axon. See National Autism Plan for Children. See National Autistic Society. A national governmental strategy for England setting out the means to address the problems of adults with autism highlighted in the Autism Bill, and now enshrined in the Autism Act 2009. (See also the Autism Bill.) A voluntary framework in the UK setting out guidelines and recommendations for good practice in relation to the identification and diagnosis of children with autism. The National Autistic Society was founded in 1962 as an organisation for people with autism, their families and carers. It acts as a forum for exchange of ideas and information, pioneers important national and international initiatives and raises public consciousness about the needs of people on the autism spectrum. Representative of real life. A class of interventions, also known as milieu approaches, that makes some use of behavioural techniques but employs them to support the development of target skills within a child's everyday environment, or in naturally occurring situations. Considered to be intermediate between adult-directed and child-centred approaches. (See also adult-directed approach; child-centred approach.) The network of neurons in the body, including the brain. The collection of cells together ensures the handling and processing of information throughout the body. The ability of synapses to change their size and ability to communicate with other neurons, muscles and organs that produce hormones. The anatomical organisation of the brain. The biology of the nervous system. The main type of cell that forms the nervous system and is specialised in processing information. A chemical involved in carrying a signal from one neuron to another. The term neurotypical (NT) was first coined within the autism community to denote people who are not on the autism spectrum. The implication is that their brain and mental functioning is typical rather than atypical, particularly in relation to communication and social interaction. The term avoids the problematic connotations of ‘normal’ (as opposed to ‘abnormal’.) It has been quite widely adopted, and is recommended by the National Autistic Society. (See also typically developing children.) An alternative term for independent schools. See definition for that term. The use of non-verbal means, including prosody (pitch, intonation and stress), facial expression and gestures, to express meaning in communication. (See also prosody.) Copyright © 2010 The Open University Chapter 5 1 5 9 2 1 3 6 5 5 5 5 5 5 6 7 3 18 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term NT object-focused attention observational method occipital lobe Ofsted operant conditioning outcome measure overly formal and stilted oxytocin paediatrics parietal lobe participants Definition See neurotypical. A term used in developmental research for attention which is focused towards objects. This is inferred from behaviours such as where a child looks, what they orient to, what they smile at or speak to. (See also social attention.) A method widely used in the natural and social sciences, focusing on naturally occurring behaviour. As such the observational method contrasts with the experimental method, which studies responses to specially devised tests in a controlled setting. The observational method usually involves coding of the observations. Coded observations are treated quantitatively in some types of observational research, and qualitatively in others. A lobe of the cerebral cortex important for many aspects of visual perception and for the processing of spatial information. The body empowered by the Education and Inspections Act of 2007 to inspect the standards in schools in England. Comparable bodies with different names operate in Wales, Scotland and Northern Ireland. A principle of learning formulated by the psychologist B.F.Skinner. Skinner stated that an organism's active behaviour 'operates' on the environment, with consequences that modify the organism's tendency to repeat that behaviour in the future. If the consequences are rewarding for the organism, the behaviour is more likely to be repeated. Skinner showed that operant behaviour can be modified (increased or reduced) by the application of reinforcement. For instance, a reward for completing homework is likely to reinforce the behaviour of completing homework. Operant conditioning using reinforcement is central to the technique of behaviour modification involved in the Lovaas approach to intervention for autism. (See also Lovaas approach; reinforcement.) A measure of the outcome of an intervention for a disorder or condition, and thus a type of dependent variable. Outcome measures used to evaluate interventions for autism spectrum conditions typically focus on changes in the participants' behaviour and/or psychological functioning. (See also dependent variable.) One of four styles of social interaction which, according to Lorna Wing, may be characteristic of adults on the autism spectrum. The adult strives to overcome their social difficulties, but tends to conform to rigid rules of behaviour, thus appearing formal and excessively polite. (See also aloof; active but odd; passive and friendly.) A hormone produced in the brain of women after stimulation of the nipples by breastfeeding. (See also hormone.) The specialist branch of medicine dealing with infants, children and adolescents. A lobe of the cerebral cortex. It is concerned with the perception of stimuli related to touch, pressure, temperature and pain (also referred to as somatosensory perception.) People who volunteer to take part in a research or clinical study. Copyright © 2010 The Open University Chapter 3 3 5 7 6 6 3 5 1 5 1 19 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term passive and friendly pathologising pathway PDD PDD-NOS PDD-unspecified PECS peer-reviewed journal perception perceptual difficulties perceptual processing perseveration pervasive developmental disorder, unspecified (PDDunspecified) pervasive developmental disorder not otherwise specified (PDDNOS) Definition One of four styles of social interaction which, according to Lorna Wing, may be characteristic of adults on the autism spectrum. The adult is able to tolerate the company of others, but does little to interact with them. He or she may seem quiet and shy rather than autistic, as long as remaining within a familiar and non-stressful environment. (See also aloof; active but odd; overly formal and stilted.) Tending to attribute all problems to medical or psychological abnormality, even when alternative, non-pathological explanations are possible. Network of neurons that are specialised for a particular neurotransmitter. For example, the serotonergic pathway refers to the collection of neurons that communicate with each other through the release of serotonin. See pervasive developmental disorders. See pervasive developmental disorder not otherwise specified. See pervasive developmental disorder, unspecified. See Picture Exchange Communication System. An academic journal that publishes articles relating to a particular theme. Articles submitted for potential publication are assessed by independent (usually anonymous) reviewers, who are experts in the area covered. Reviewers will only pass articles for publication if they are satisfied that they are coherent and scientifically sound. The processes involved in organising and interpreting information provided by the different sense organs. (See also sensation; sense organs; sensory processing.) Difficulties in processing, integrating and making sense of information received via the sense organs. Various forms of difficulty are common in people on the autism spectrum. Spontaneous activity of the nervous system, including the brain, in interpreting and making sense of information transmitted by sense organs. The distinction between sensory processing and perceptual processing is not always well-defined. For instance, the eye is a sense organ, but perceptual processing also commences in the retina of the eye. Inability to relinquish a rule, strategy or activity that has become ineffective or unhelpful. A formal diagnostic term within the ICD-10 system, used for individuals with autistic-like symptoms, but where the information is inadequate, incomplete or contradictory, such that criteria for the more specific diagnosis of childhood autism (the ICD-10 term for classic autism) cannot be met. (See also PDD-NOS; atypical autism.) Chapter 3 A formal diagnostic term within the DSM-IV-TR system, used in relation to individuals with autistic-like symptoms who do not meet the strict criteria for autistic disorder (the DSM term for classic autism.) In DSM-IVTR the term atypical autism is used interchangeably with PDD-NOS. (See also PDD-unspecified; atypical autism.) 2 Copyright © 2010 The Open University 8 5 6 1 1 3 4 2 20 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term pervasive developmental disorders (PDD) pharmacological interventions phenomena phenotype phonology picture completion test Picture Exchange Communication System (PECS) pilot pitch planning pointing Definition A broad 'umbrella’ term used in both DSM-IV-TR and ICD-10 for conditions characterised by difficulties in communication, social interaction and range of activities and interests. 'Pervasive' means that the difficulties embrace many key aspects of developmental, rather than just a specific developmental capacity such as language or reading. The main conditions included under this heading are the sub-types of the autism spectrum- classic autism, Asperger syndrome and PDD-NOS. A small number of much rarer conditions are sometimes considered part of the autism spectrum and sometimes not. (See also DSM; ICD; autism spectrum.) Interventions involving the use of medicines, i.e. drugs. Chapter 1 Phenomena is the plural of phenomenon, a Greek word meaning an observable event or occurrence. In psychology, the term phenomena is used quite broadly to mean directly observable aspects of human behaviour, such as the way a person speaks or moves, and less observable aspects of cognition, such as how a person's memory works, which must be inferred from their responses in psychological tasks. Phenotype means the sum of an individual’s characteristics, as determined by the combined effects of their genetic make-up or genotype with environmental influences. The phenotype comprises all those characteristics of an individual which are 'observable', including directly observable characteristics such as eye colour, height and physique, and others such as blood group and IQ, which are indirectly observable using scientific instrumentation and/or psychological tests. The system of rules governing how the words in a language should sound. A grasp of phonology means that a person understands how words should be pronounced, and also how to make sense of sequences of speech sounds that he or she hears. As such, phonology is an aspect of both expressive and receptive language ability. The term phonology also means the study of the rules governing the sound of language. (See also expressive language; receptive language.) A sub-test within a non-verbal IQ test, in which the participant is asked to arrange some coloured blocks to copy a geometric pattern. (See also intelligence tests.) An intervention widely used in clinical, educational and home settings to help children on the autism spectrum communicate using pictures or symbols. Especially suited for children with classic autism and little or no language. A preliminary study conducted in advance of a full-scale research study. In clinical work, a pilot may be an informal evaluation of a proposed intervention involving a single participant or a very small group of participants. Refers to whether a sound is high or low. The pitch of speech plays a role in communication and may be atypical in people on the autism spectrum. Mentally organising one's actions to achieve a goal. A component of executive function. (See also executive function.) The use of the index finger to indicate an item of interest. 3 Copyright © 2010 The Open University 6 9 3 3 2 6 2 4 3 21 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term polygenic positive reinforcement post-mortem study pragmatics prevalence primary intersubjectivity probability prodigious skills prognosis prompt fading pronoun reversal prosody Definition A condition or trait that is due to the combined effects of multiple genes (as opposed to the influence of a single gene.) In each individual with autism, the condition is likely to be due to a combination of different genes acting together. There is also genetic heterogeneity for autism: the set of genes involved in causing autism in the one individual may be different from the set of genes predisposing to autism in another individual. (See also genetic heterogeneity.) A central principle in behaviour modification and behavioural interventions. Involves shaping an individual's behaviour by the application of influences known as reinforcers which increase the frequency of a particular response. Often the influence will have the quality of a reward which the individual works to receive by the way they behave. For instance a child may be encouraged to sit still at a table by the positive reinforcement of a sweet, which is given each time the child manages to sit still. (See also behavioural interventions; behaviour modification; operant conditioning; reinforcement.) The study of tissues that takes place after an organism has died. Postmortem studies of brain tissue have shed useful light on structural atypicalities in autism. The aspect of language function concerning the ability to produce and receive language effectively for purposes of two-way communication. This requires the ability to come up with the right utterances in social context, and also to understand how social context affects the meaning of what other people say. The number of cases of a condition within a population at a particular time. A term derived from the work of Colwyn Trevarthen meaning that infants and their mothers are ‘pre-programmed’ to respond to each other’s behaviour, triggering an ongoing cycle of reciprocal interaction in which the child’s and mother’s behaviour is closely attuned and synchronised. Mathematical odds. Under the broad heading of savant syndrome, a prodigious skill is a talent so exceptional or outstanding that it is likely to attract widespread public interest. Such prodigious skill is typically in an area such as visual art or musical performance. An example is the work of the autistic artist Stephen Wiltshire. (See also savant syndrome; splinter skills; talents.) A prediction offered by a medical or other expert concerning the probable course and outcome of a disorder or condition. A behavioural technique in which an adult initially provides physical prompts for a child's actions, but gradually reduces the prompts as the child becomes more familiar with the actions. (See also naturalistic approaches.) Also known as pronominal reversal and meaning the use of impersonal pronouns such as 'you', 'he', 'she' instead of 'I' or 'me'. This language impairment, which is common in autism, often occurs together with echolalia. For instance, the answer to 'do you want a biscuit' might be an exact repetition of this phrase to mean 'yes I would like a biscuit'. (See also echolalia.) Non-verbal aspects of a person's speech such as pitch, intonation and stress that help to convey meaning in communication. (See also pitch; intonation; stress.) Copyright © 2010 The Open University Chapter 5 1 5 3 1 4 1 3 8 6 1 3 22 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term prosopagnosia protodeclarative pointing protoimperative pointing psychiatry psychological perspective psychometric techniques psychosocial interventions qualitative method quantitative method RAD randomised control trial (RCT) RDI reactive attachment disorder (RAD) Definition A condition in which the ability to recognise faces is seriously impaired, while the ability to see and recognise objects and other physical entities is intact. Prosopagnosia occurs in a proportion of people on the autism spectrum but the frequency is not known. The use of pointing to draw someone else's attention to an object or item of interest, thus enabling the individual to share their interest with another. Thus a child might point protodeclaratively to a bird so that his mother will look at it too. Children on the autism spectrum tend not to use this form of pointing. (See also protoimperative pointing.) The use of pointing to indicate an object or item that the individual wants or desires. Thus a child might point protoimperatively to a biscuit to convey that they want to have it. Children on the autism spectrum may use this form of pointing. (See also protodeclarative pointing.) The branch of medicine that deals with the understanding and treatment of mental disorders and problems affecting the mind. Seeking to understand and explain aspects of human behaviour in terms of psychological concepts and theories. Techniques that provide ways of measuring intelligence, language skills and other cognitive and behavioural capacities or traits. Interventions that aim to influence an individual’s behaviour, social and communication skills and/or thinking processes. Such interventions are directly or indirectly informed by knowledge of learning and other psychological processes. Psychosocial interventions are the most widely used and successful type of interventions for people on the autism spectrum. A type of research method typically used to gather rich descriptive information which is difficult to quantify or measure. (See also quantitative method.) A type of method used to gather quantitative data, that is, information dealing with numbers and anything that is measurable. Quantitative methods are the norm in natural sciences such as physics, chemistry and biology, and are also widely used in the disciplines relevant to studying autism, including psychology. Quantitative methods in these fields include experiments, questionnaires, psychometric techniques, and certain forms of observational study. These methods contrast with qualitative methods, which do not involve measurement. A combination of quantitative and qualitative methods is sometimes very useful in elucidating psychological phenomena. (See also qualitative method.) See reactive attachment disorder. A systematic method for evaluating interventions in which participants are assigned randomly to intervention and control groups. The purpose of random allocation is to avoid biases in the group of participants selected for the intervention which may affect the outcome of the evaluation. See Relationship Development Intervention programme. The clinical and diagnostic term for a condition characterised by markedly disturbed and developmentally inappropriate ways of relating socially in a range of situations. Unlike autism spectrum conditions, RAD may reflect emotional attachment problems resulting from a lack of nurturing in early childhood. Copyright © 2010 The Open University Chapter 3 3 3 1 3 9 6 9 9 6 9 23 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term receptive language reciprocity reflexivity regression reinforcement Relationship Development Intervention (RDI) programme replication Research Autism residential school resilience respite care or provision rote memory Definition The process of receiving and understanding language which is spoken or written by others. Difficulty with receptive language means that the person has delay and/or difficulty in making sense of what other people say or write down. Problems are likely to include difficulty in understanding vocabulary or grammar, difficulty in distinguishing speech sounds and in understanding the meaning of sentences. Difficulty with receptive language is common on the autism spectrum and is often accompanied by expressive language difficulty. (See also expressive language.) Processes of ‘give and take’ and ‘turn-taking’ in communication and social interaction. A term with several different meanings. In the context of developmental psychology, reflexivity means the capacity to reflect on one's own thoughts, or to have an 'inner dialogue'. This is thought to play an important role in developing the child's ability to see themselves as a self or individual distinct from other individuals. Regression is the phenomenon in which a child first seems to be developing normally, and then the development ‘tails off’ and even reverses to behaviour the child showed at a younger age. Regression is most notable for language development. A central principle in behaviour modification and behavioural intervention. Involves shaping an individual's behaviour by the application of influences known as reinforcers which increase or decrease the frequency of a particular response. (See also behaviour modification.) A developmental-pragmatic child-centred intervention in which parents are trained to foster the social communication skills of their child with autism via stimulating and enjoyable activities. Parents are trained to use indirect prompts and invitations rather than directive forms of interaction. (See also child-centred; developmental-pragmatic approaches.) Replication is said to occur when a research study is repeated, sometimes with slight variations, with the same outcome. Replication plays an important role in establishing if a research finding is robust. A UK charity dedicated to research into interventions for autism. The organisation supports and/or commissions independent evaluations of new and existing health, education, social and other interventions. Their website includes a database of interventions with ratings of their current evidence base. A school that provides overnight accommodation and 24 hour support for children and young people on the autism spectrum, sometimes up to 23 years of age. Residential schools typically cater for more profoundly affected individuals. This definition refers to the UK but similar provision exists in some other countries. (See also mainstream school; special school.) The ability to withstand hardship and to overcome adversity, becoming stronger and more resourceful as a result. A short residential break away from the family for a person with a disability such as autism. This is designed to provide a rest and 'breathing-space' for other family members. Learning or memorisation by accurate repetition e.g. word by word recall of a string of words. The term may also imply that memorisation takes place without an understanding of the reasoning or relationships involved in the material that is remembered. Copyright © 2010 The Open University Chapter 3 3 4 5 1 6 4 6 7 8 8 1 24 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term sample savant syndrome screening second-order false belief secondary intersubjectivity seeing leads to knowing selective serotonin reuptake inhibitors (SSRIs) self-injurious self-reference effect semantics SENCo sensation sense organs sensory hypersensitivity sensory hyposensitivity Definition The group of individuals who are selected from a wider population to take part in a study. An isolated, narrow area of ability or skill in the context of profound disability. The term is often treated as an umbrella term for abilities ranging from moderately developed splinter skills, through talents, to prodigious skills which are sufficiently outstanding to attract widespread attention and interest. It is estimated that about 30% of individuals on the autism spectrum have an area of special skill, though very few have prodigious skills. (See also splinter skills; talents; prodigious skills.) A procedure for identifying which individuals in a population have, or are at risk of developing, a certain condition. A complex form of false belief in which a person understands that a second person has a false belief about a third person's belief about a situation. A term from the work of Colwyn Trevarthen for the phase, during the second year of life, when typically developing infants not only coordinate one-to-one with a parent, but also start to join with the parent in attending to something or someone else. Refers to the fact that a person’s belief or knowledge about a situation depends partly on what perceptual information has been available to them. A group of antidepressant drugs that act to increase the availability of the neurotransmitter serotonin in the brain. Serotonin is thought to be involved in mood regulation. Self-harming behaviour such as head banging, scratching, biting, or eye gouging. A reported phenomenon in which people tend to remember more about their own actions and experiences than about those of other people. The aspect of language function that relates to using words appropriately to convey meaning, and to understanding the meaning of words, phrases and sentences. See Special Educational Needs Coordinator. The detection of information from the environment by specialised sense organs (See also sense organs; sensory processing). Specialised systems in all animals that enable them to detect and process information from the environment. In humans the main sense organs are eyes, ears, touch receptors in the skin, smell receptors in the nostrils, taste receptors in the tongue, movement receptors in muscles and joints, and balance receptors in the inner ear. Heightened sensitivity to sounds, tastes, visual and other stimuli, compared with what most people experience. Common in people on the autism spectrum. (See also sensory hyposensitivity.) Reduced sensitivity to sounds, tastes, visual and other stimuli compared with what most people experience. Common in people on the autism spectrum. (See also sensory hypersensitivity.) Copyright © 2010 The Open University Chapter 5 3 2 4 4 4 6 8 9 3 1 3 1 1 25 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term sensory overload sensory processing serotonin sex-linked sibling recurrence risk SLT social attention social cognition Social Communication Clinic social pragmatic approaches Social Stories somatosensory perception Son-Rise programme Definition Broadly defined as a state in which individuals are exposed to many sensory stimuli, or to stimuli at such high intensities, that they become unable to deal with them. For instance, they may become very stressed and/or become unresponsive to sensory input. In autism, hypersensitivity to sensory stimuli means that a person may experience overload even for moderate levels of stimulation that would not be disagreeable for a person without autism. The means by which we acquire information about the environment through specialised sense organs, each of which deals with a different modality or dimension of input. (See also sensation; sense organs.) A neurotransmitter involved in complex brain processes, including the regulation of mood, emotions, aggression, sleep and body temperature. (See also neurotransmitter.) A term for characteristics that are coded by genes located on the X chromosome. Since females have two X chromosomes, while males only have one, a characteristic coded by a particular allele of a gene located on the X chromosome may be expressed in males but masked in females. The likelihood that a condition diagnosed in one family member will also occur in his or her sibling. See speech and language therapist. A term used in developmental research for attention that is focused on people and other social stimuli. It is inferred from behaviours such as whether the child looks at people, orients to them, smiles at them or vocalises (makes sounds) to them. An aspect of cognition concerned with how people process and make sense of social information, especially other people’s behaviour and ‘mental life’ – what they are thinking and feeling. A term for a clinic specialising in assessing children with language and communication difficulties. Children with problems that might indicate an autism spectrum condition are often referred to Social Communication Clinics. (See also Child Development Centre.) An alternative term for developmental-pragmatic approaches. See definition for that term. An intervention designed to help children on the autism spectrum understand social situations and react appropriately. The child is provided with stories describing social situations as if from the child's perspective, with concrete description of details and examples of appropriate responses. The perception of stimuli related to touch, pressure, temperature and pain. An intervention originally developed by the Kaufmans to help their own son, Raun. As a child-centred intervention, the approach involves following the child’s interests and motivation as a means of encouraging interaction and learning. For instance, a parent might join in their child's repetitive and ritualistic behaviours or build on the child's interest in something as an opportunity for learning. Strong but currently unsubstantiated claims have been made for recovery through use of this programme. (See also child-centred approach.) Copyright © 2010 The Open University Chapter 3 3 5 9 5 3 1 2 6 7 5 6 26 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term Special Educational Needs Coordinator (SENCo) special school specificity speech and language therapist (SLT) SPELL (Structure, Positive, Empathy, Low arousal, Links) splinter skills SQ SSRIs Statement of Special Educational Needs statistical tests statistically significant stereotypy Definition A teacher within a school with responsibility for overseeing the teaching of children with special needs. Chapter 2 A school or stand-alone unit whose main purpose is to provide education specially suited to the additional support needs of children and young persons with a significant level of special educational needs. Some special schools are designed specifically for children on the autism spectrum, while others cater for a range of special needs. This definition refers to the UK but similar provision exists in some other countries. (See also mainstream school; residential school.) A criterion to be considered in evaluating theories of autism. A specific factor or influence is one which affects only individuals on the autism spectrum, rather than one which also affects individuals with other conditions. A theoretical explanation which identifies such a specific influence is likely to be more useful and convincing than one which does not identify such a specific factor. (See also testability; universality.) A health professional whose role is to assess and treat children and adults with speech, language and communication difficulties. 7 The National Autistic Society 'whole school' framework for understanding and responding to the needs for children, young people and adults with autism. The acronym stands for Structure: a structured environment, together with communication and learning activities with clear guidelines which promote effective learning by increasing consistency and predictability; Positive: approaches and expectations; Empathy: ability to identify with and understand the feelings or difficulties of the person with autism; Low arousal: an environment where distraction and aversive factors are kept to a minimum; Links: the framework focuses on environment, communication and staff interaction with children and adults with autism. (See also whole school approach.) Under the broad heading of savant syndrome, the term splinter skill refers to a well-developed ability in an individual with other cognitive disabilities. For example, an individual with a low IQ may nonetheless be able to complete complex jigsaw puzzles. (See also savant syndrome; talents; prodigious skills.) See systemising quotient. See selective serotonin re-uptake inhibitors. A legal document that identifies the type of support a child with some form of disability or learning problem would need at school. 7 Tests designed to evaluate the probability that an observed result (e.g. in an experiment) is statistically significant, or has occurred by chance alone. Conclusions can only be drawn from the study if the result is statistically significant. (See also probability; statistically significant.) Refers to a result that is highly unlikely to have occurred by chance. Often the term 'significant' is used alone. A repeated or ritualistic movement, posture or utterance. It is a common type of symptom in people on the autism spectrum, and also occurs in certain movement disorders. 1 Copyright © 2010 The Open University 4 2 3 2 1 3 27 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term stress structured schedule sulcus symbolic capacity symptoms synapse syndrome synesthesia syntax systematic methods systematic review systemising Definition The use of emphasis within speech to mark particular words or phrases. Stress plays a role in communication, and may be atypical in people on the autism spectrum. A method used in research interviews to ensure consistency in the treatment of different interviewees. The structured schedule specifies the topics to be covered and the way the questions are asked. The foldings of the cortex in the brain that form a groove are referred to as sulci (singular term is sulcus.) A symbol is something such as a numeral, object, pictorial symbol or word that represents or stands for something else. Symbolic capacity, broadly defined as the capacity to understand and operate with such symbols, is essential for language understanding, and for activities such as pretence and imagination. In order to pretend, a child must be able to treat one object or entity (say a stick) as if it were another (say a sword.) Features or characteristics that may indicate a clinical problem or disorder. In some medical conditions (e.g. flu), symptoms may be feelings that the individual experiences and reports to a doctor. In other conditions, such as autism, an individual's symptoms are more likely to be atypical behaviours observed by others such as the individual's parent, or a clinician. Symptoms form the basis for formal diagnostic classifications such as DSM-IV-TR or ICD-10. The junction between two neurons where communication takes place via neurotransmitters that cross the synapse. A term denoting a co-occurring and characteristic set of symptoms, usually assumed to be caused by a specific underlying disorder, even if the causal mechanism is not well understood. Many syndromes are named after the physicians credited with first reporting the association, hence Kanner's syndrome and Asperger syndrome. Autism is now considered more as a spectrum rather than as one or more specific syndromes. (See also autism spectrum.) The phenomenon in which specific sensory or perceptual stimuli consistently trigger a different sensory or perceptual system from the one receiving input. Thus a person may see a colour when hearing a sound or tasting something, or when seeing particular numbers, letters or words. Synesthesia occurs in a proportion of people on the autism spectrum, but the frequency is not known. A set of rules governing the ordering of words in sentences. Technically a branch of grammar. (See also grammar.) Studies in which the conclusions are derived from careful objective evaluation of evidence following scientific principles. An evaluation of evidence for the success of an intervention, based on a review of findings conducted with clearly defined criteria, e.g. only controlled studies carried out by independent researchers. Systemising is defined by Simon Baron-Cohen as the drive to analyse or construct systems, where a system is any domain that lends itself to a set of rules predicting or explaining how the domain works. Baron-Cohen proposes that people with autism have a cognitive profile characterised by a high level of systemising ability, together with a low level of empathising ability. (See also empathising-systemising.) Copyright © 2010 The Open University Chapter 2 1 5 3 1 5 1 3 3 1 6 4 28 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term systemising quotient (SQ) talents TEACCH Teaching Assistant temporal lobe testable / testability theoretical construct theory theory of mind (ToM) Treatment and Education of Autistic and related Communicationhandicapped Children (TEACCH) triad of impairments twin method Definition A questionnaire-based measure devised by Baron-Cohen and colleagues to assess levels of systemising. The assumption underlying the test is that systemising is a dimensional or continuous trait. Each member of a population can receive a low, high or average score on systemising; on average males are predicted to score higher than females; people on the autism spectrum are predicted to score very high on systemising. (See also empathising-systemising theory; systemising.) Under the broad heading of savant syndrome, talent refers to a highly developed and noticeable skill, such as the capacity to paint accomplished pictures, or to do difficult mental calculations. (See also savant syndrome; splinter skills; prodigious skills.) See Treatment and Education of Autistic and related Communicationhandicapped CHildren An alternative term for Learning Support Assistant. See definition for that term. A lobe of the cerebral cortex, it is involved in memory and language functions and is concerned with perceiving and recognising auditory information. Refers to the need for a scientific theory to be formulated so that it makes clear predictions about what outcomes should occur if it is correct. Testability can thus be considered a criterion for evaluating the potential usefulness of a theory: if it is not testable, it is not a useful theory. A concise summary of theoretical ideas about the structures or processes underlying observable events or behaviour. Theoretical constructs in psychology are often formulated from observations of how people perform in experimental tasks. A theory provides an account of a set of observed phenomena in terms of principles which offer an explanation of how and why the phenomena occur. In science, theories often seek to identify the cause of the phenomena in question. The capacity to understand what other people are thinking, believing and feeling. Most people on the autism spectrum are thought to have difficulties with theory of mind; they may not understand mental states; they may even be unaware that other people have a 'mental life'. A programme of intervention for autism first developed in the USA in the 1970s, and widely used in educational, home and other settings. TEACCH is designed to address core problems such as the need for structure to harness common autistic skills, such as visual abilities and attention to detail, and to promote the development of independence. This often involves use of a visual timetable or planner, tailored to the needs and interests of the individual. Term for the three main and characteristic areas of difficulty in autism, namely communication, social interaction and repetitiveness in activities and interests. Difficulties in these three areas are the main symptoms used in formal diagnosis of autism. A research method used to evaluate how frequently a particular condition or characteristic co-occurs in monozygotic (identical) twins as compared with dizygotic non-identical) twins. Higher co-occurrence (concordance) in monozygotic twins provides evidence that the condition or characteristic is genetically inherited. Used in exploring the genetic basis for autism. (See also concordance; concordance rate; monozygotic twins; dizygotic twins.) Copyright © 2010 The Open University Chapter 4 3 6 5 4 9 4 4 6 1 1 29 The Autism Spectrum in the 21st Century: Exploring Psychology, Biology and Practice Term typically developing children UK National Screening Committee universality variable vertical axis WCC weak central coherence (WCC) white matter whole school approach X and Y chromosomes Definition Term used (e.g. in research) when comparing the characteristics of children with autism with a group without autism. The opposite of the term 'typically developing' is 'atypically developing'. Hence this phrase avoids implying that the autistic group is 'abnormal'. (See also neurotypical.) A committee of health professionals who make decisions about whether screening instruments should be used within the UK National Health Service. A criterion to be considered in evaluating theories of autism. A universal factor or influence is one that affects all individuals on the spectrum, rather than just a proportion of individuals. A theoretical explanation that identifies such a universal influence is likely to be more useful and convincing than one that does not identify a universal influence. (See also testability; specificity.) A variable is something that varies, either along a dimension, such as height or weight, or from one group to another, such as gender (male or female) or eye colour (blue or brown.) An independent variable in an experiment is something that the experimenter manipulates (e.g. whether participants have an autism diagnosis or not.) A dependent variable is what the experimenter observes to vary as a result of manipulating the independent variable (e.g. how participants with or without an autism diagnosis perform on a memory task.) (See also experiment; hypothesis; experimental group; control group.) The vertical dimension of a graph. Also known as the 'y'-axis. (See also graph.) See weak central coherence. Focusing on individual details rather than overall form and meaning when processing information from the environment. This has been considered as both a perceptual phenomenon (perceiving individual details in scenes, music, etc.) and a conceptual phenomenon (processing individual words rather than meaning or gist from written or spoken language.) A key theory of autism suggests that it is characterised by weak central coherence, though this is now proposed as a preferred cognitive style rather than a fixed deficit in processing information. (See also central coherence; cognitive style.) Refers to the underlying regions of the brain that are primarily composed of the axons of neurons. Because the axons are encased in myelin, these brain areas look pale and are therefore referred to as white matter. A framework for educating and supporting children on the autism spectrum, comprising a collection of interventions, strategies and therapies that are integral to the organisation and culture of the school. (See also Daily Life Therapy; SPELL.) Sex chromosomes. Body cells of human females typically possess two X chromosomes, while the cells of males have one X chromosome and one Y chromosome. (See also chromosomes; sex-linked.) Copyright © 2010 The Open University Chapter 1 2 4 1 3 4 5 7 5 30