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Urinary System Interactions Endocrine System Nervous System • Kidneys dispose of nitrogenous wastes; maintain fluid, electrolyte, and acid—base balance of blood; produce the hormone erythropoietin; renal regulation of Na+ and water balance essential for blood pressure homeostasis and hormone transport in the blood • ADH, aldosterone, ANP, and other hormones help regulate renal reabsorption of water and electrolytes • Kidneys dispose of nitrogenous wastes; maintain fluid, electrolyte, and acid-base balance of blood; renal regulation of Na+, and Ca2+ content in EOF essential for normal neural function • Neural controls involved in micturition; sympathetic nervous system activity triggers the renin—angiotensin mechanism Cardiovascular System • Kidneys dispose of nitrogenous wastes; maintain fluid, electrolyte, and acid-base balance of blood; renal regulation of Na” and water balance essential for blood pressure homeostasis. Na+, and Ca2+ reguIation help maintain normal heart function • Systemic arterial blood pressure is the driving force for glomerular filtration; heart secretes atrial natriuretic peptide; blood vessels Q transport nutrients, oxygen, etc. to urinary organs Immune System • Kidneys dispose of nitrogenous vvastes; maintain fluid, electrolyte, and acid—base balance of blood • By returning leaked plasma fluid to cardiovascular system, lymphatic vessels help ensure normal systemic blood pressure needed for kidney function; immune cells protect urinary organs from infection, cancer, and other foreign Muscular System Respiratory System • Kidneys dispose of nitrogenous wastes; maintain fluid, electrolyte, and acid—base balance of blood; renal regulation of Naf KT and Ca2+ content EOF crucial for muscle activity • Muscles of pelvic diaphragm and external urethral sphincter function in voluntary control of micturition; creatinine is a nitrogenous waste product that must be excreted by the kidneys f• Kidneys dispose of nitrogenous wastes; maintain fluid, electrolyte, »a_ and acid-base balance of blood • Respiratory system provides oxygen required by kidney cells; disposes of carbon dioxide; cells in the lungs convert angiotensin I to angiotensin ll Digestive System • Kidneys dispose of nitrogenous wastes; maintain fluid, electrolyte, and acid-base balance of blood; also, metabolize vitamin D to the active form needed for calcium absorption • Digestive organs provide nutrients needed for kidney cell health; liver synthesizes most urea, a nitrogenous vvaste that must be excreted by the kidneys lntegumentary System • Kidneys dispose of nitrogenous wastes; maintain fluid, electrolyte, and acidbase balance of blood • Skin provides external protective barrier; serves as site for water loss (via perspiration); vitamin D synthesis site Reproductive System • Kidneys dispose of nitrogenous wastes; maintain fluid, electrolyte, and acid-base balance of blood Skeletal System • Kidneys dispose of nitrogenous wastes; maintain fluid, electrolyte, and acid-base balance of blood • Bones of rib cage provide some protection to kidneys