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Transcript 
Does Cardiac Resynchronization Therapy Benefit Patients
With Right Bundle Branch BlockResponse to Angelo
Auricchio, MD, PhD, Joost Lumens, PhD, and Frits W.
Prinzen, PhD
by Angelo Auricchio, Joost Lumens, and Frits W. Prinzen
Circ Arrhythm Electrophysiol
Volume 7(3):532-542
June 17, 2014
Copyright © American Heart Association, Inc. All rights reserved.
Electroanatomic mapping and surface 12-lead ECG in a patient with right bundle branch block
(RBBB; A), in a patient with RBBB masking left bundle branch block (LBBB; B), and in a patient
with LBBB (C).
Angelo Auricchio et al. Circ Arrhythm Electrophysiol.
2014;7:532-542
Copyright © American Heart Association, Inc. All rights reserved.
Two patient examples of different right bundle branch block (RBBB) morphology (A, RBBB
masking left bundle branch block [LBBB]; B, RBBB without LBBB) and radial strain
dyssynchrony, with ejection fraction (EF) response and long-term outcome after cardiac
resynchronization therapy (CRT).
Angelo Auricchio et al. Circ Arrhythm Electrophysiol.
2014;7:532-542
Copyright © American Heart Association, Inc. All rights reserved.
Acute hemodynamic response to conventional biventricular (BiV) pacing in various computer
simulations of a failing heart with synchronous ventricular activation, right bundle branch block
(RBBB), left bundle branch block (LBBB), or a combination of RBBB and LBBB. Note that
cardiac resynchronization therapy (CRT) hardly improves or even deteriorates cardiac pump
function in hearts with RBBB in the absence of sufficient coexistent left ventricular (LV)
activation delay.
Angelo Auricchio et al. Circ Arrhythm Electrophysiol.
2014;7:532-542
Copyright © American Heart Association, Inc. All rights reserved.
Mechanistically based flow chart indicating possible implantation strategies in cardiac
resynchronization therapy (CRT) patients presenting with right bundle branch block and electric
or mechanical activation delay of the left ventricle (LV).
Angelo Auricchio et al. Circ Arrhythm Electrophysiol.
2014;7:532-542
Copyright © American Heart Association, Inc. All rights reserved.
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