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Abstract POSTER TITLE WILL GO HERE. IT SHOULD TAKE UP ONE OR TWO LINES AND BE APPROXIMATELY THIS SIZE Authors Line - smaller and not bold Affiliations and addresses Affiliations and addresses Methodology 1. A549, PC-3 and TSU-PR1 cells were grown in cell culture in RPM1 medium. Logarithmic phase cells were exposed to PDX or PDX with PBCD for 3 hrs and IC50 values in each case determined after further growth in PBCD for 96 hrs. 2. The murine Lewis Lung, human LX-1 lung, A549 NSC lung, PC-3 and TSU-PR1 prostate and MX-1 breast tumors were transplanted sc in BD2F1 (Lewis Lung) or NCR-nu (human tumors) mice. 3. Mice with well established tumors were treated ip with an MTD of PDX (60 mg/kg) or PDX (60 mg/kg) and PBCD (125 mg/kg) q3-4d x 4. 4. Treated and control mice were evaluated for tolerance and efficacy (tumor size) during and up to 10 days after treatment. 90 80 70 60 50 East West North 40 30 20 10 0 1st Qtr 2nd Qtr 3rd Qtr 4th Qtr References Siller GM, Marcus A, Savage N. Minocyclineinduced Oral Hyperpigmentation. J Am Acad Dermatol. 1994;30:350-4. Meyerson M, Cohen P, Hymes S. Lingual Hyperpigmentation Associated with Minocycline Therapy. Oral Surg Oral Med Oral Pathol Oral radiol Endod. 1995;79:180-4. fig x: Any figure caption can be written in this space. Any of the boxes can be altered as to size and shape. Chu P, Van S, Yen B, Berger T. Minocycline Hyperpigmentation Localized to the Lips: An Unusual Fixed Drug Reaction? J Am Acad Dermatol. 1994;30:802-3. Basler R. Minocycline-related Hyperpigmentation. Arch Dermatol. 1985;121:606-8.