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The department of biophysics and medical image processing was created in Amiens’University hospital
(France) in 1995. This research department established in the heart of the hospital, close to the clinical services,
develops new treatment and analysis tools for MRI and PET images. It is specialized in physiology and
physiopathology studies of CSF and blood flows starting from the acquisition of Phase contrast MRI images.
This set of research themes is based upon an original treatment methodology of MRI images. We developed the
first image processing software of CSF flow. This software, under constant evolution, enables us to quantify the
CSF and blood flows, and their respective interactions during cardiac cycle. We have characterized the
cerebral biological flows at various ages of life and in various pathologies. This fundamental research on CSF
and blood flows now leads to clinical applications such as a diagnosis help in cerebral hydrodynamics
disorders. In close cooperation with the services of radiology, neurosurgery, geriatrics and pediatric, we apply
our investigation experience to the transverse study of pathologies having a potential link with CSF or blood
flows.
A phase-contrast MRI study of physiologic cerebral venous flow. Stoquart-Elsankari S, et all. J Cereb Blood Flow Metab. 2009
Aging effects on cerebral blood and cerebrospinal fluid flows. Stoquart-ElSankari S, et all. J Cereb Blood Flow Metab. 2007
Relationship between cerebrospinal fluid and blood dynamics in healthy volunteers and patients with communicating hydrocephalus.
Balédent O, et all. Invest Radiol. 2004
Cerebrospinal fluid dynamics and relation with blood flow: a magnetic resonance study with semiautomated cerebrospinal fluid
segmentation. Balédent O, et all. Invest Radiol. 2001
Facilities:
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Group has MRI (3T and 1.5T) an PET research and clinical access
CSF and blood dynamics is investigated directly using PC-MRI.
Mathematical model of CSF circulation and CBF
endoscopic third ventriculostomy are realized in the neurosurgical department
image processing software for PET and MR images are developed in our research group
Cerebral Hydraulic phantom is developed in our research group
Most important projects so far were devoted to:
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Segmentation Software for PCMRI images
Relationships between CSF and Blood flow in healthy volunteers
Characterization of CSF and blood flows in hydrocephalus patients, in acute subarachnoid
hemorrhage, in ageing people and Alzheimer patients
Characterization of CSF and blood flows in newborn and premature patients with intraventricular
hemorrhage
The last project : Physiology and physiopathology of the fluids, tissues, pressure interactions in the
human central nervous system is financed by European funds, Intereg IVA and realized in cooperation
with university of Cambridge :