Download Pharmacology and Toxicology

CLINICAL PHARMACOLOGY
I. Name of the unit offering the course: Department of Clinical Pharmacology
II. Head of the unit/ course coordinator: prof. dr hab. n. med. Grzegorz Grześk
III. 6th year, number of hours: 30
IV. Form of classes: seminars: 15, tutorials: 15
V. Form of crediting: credit with grade
VI. Number of ECTS points: 2
VII. Aims of the subject:
1) Understanding the mechanism and effects of drugs with particular emphasis on
therapeutic activities, adverse reaction (side effects), toxicity, teratogenic,
embiotoxic and carcinogenic effects;
2) Assimilating the principles of clinical procedures in cardiovascular disease, urinary
system, alimentary system, hematopoietic system and evaluation of drug action,
analysis of the risks and benefits. Understanding the paths of drug dosing,
pharmacokinetic basics and principles of drug dosing;
3) Reasonable chemioteraphy, the use of antibiotics, antimycoctic and antivirus drugs
4) Placental transfer of drugs;
5) Objective clinical methods for drug acting efficiency on humans with particular
emphasis on risks and benefits evaluation;.
6) Pharmacokinetic and pharmacodynamical interactions.
IX. Topics of lectures/ tutorials/ seminars
Seminars and tutorials:
1) Clinical Pharmacology of drugs acting on cardiovascular system:

Pharmacotherapy of coronary disease;

Pharmacotherapy of coronary attack

Drugs used in pharmacotherapy of heart failure;

Treatment of hypertension- clinical examples;

Reasonable therapy of heart muscle insufficiency.
2) Arteriosclerosis and metabolizm of lipoproteins. Lipid- lowering drugs:

Clinical basics of hyperlipidemics treatment.
3) Homeostasis and thrombosis- clinical examples.
4). Pharmacokinetic of respiratory system- clinical examples:

Bronchial asthma- clinical examples;

COPD (chronic obstructive lung disease);

Acute spastic states.
5). Pharmacotherapy of urial system:

Urolithiasis- clinical examples;

Urinary tract infection therapeutic treatment;

Acute and chronic renal failure- clinical examples.
6). Pharmacotherpay of digestive system:

Duodenal ulcer- clinical examples;

Reflux disease- methods of treatment;

Pancreatitis (acute, chronic) - clinical examples;

Hepatisis.
7). Disease of endosecretory glands:

Diabetes mellitus;

Thyroid’s and parathyroid failures- clinical examples;

Hypothalamus and Hypophysys failures;

Adrenal diseases.
8). Osteoporosis.
9). Menopause.
10). Andropause – hormonal- replacement therapy.
11). Drugs interactions:

Pharmacokinetic;

Pharmacodnamical- clinical examples.
X. Self study topics.
XI. Booklist:
XII. Detailed list of required practical skills and confirmation of completing