Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
3XUVXLQJDEULJKWIXWXUHZLWKPL[LQJWHFKQRORJ\ -"NIPPON MONOZUKURI" INNOVATOR - Oh! Pulverization to 100 nanometers in only 2 minutes!? 3ODQHWDU\&HQWULIXJDO 1DQR3XOYHUL]HU FH%)(( 3ODQHWDU\&HQWULIXJDO1DQR3XOYHUL]HU FH%)(( Nano pulverization at low temperature. Ultralow volume (100 mg) pulverization is completed in 2 minutes at the shortest. Ǥ ͵ ϐ ǡ Ǥ Ǧ ʹǤǦͳͲͲ Ǥ Ǥ ■$FFHVVRULHV ■3XOYHUL]H([DPSOHV ●3XOYHUL]DWLRQFRQWDLQHUVHW PO]LUFRQLDFRQWDLQHUVDGDSWHUV 6SHFLDO FRQWDLQHUV DQG DGDSWHUV DUH PDGHRI]LUFRQLDZLWKH[FHOOHQWDEUDVLRQ UHVLVWDQFH &RQWDPLQDWLRQ IURP WKH PHGLXPDQGWKHFRQWDLQHUVJHQHUDWHG GXULQJ SXOYHUL]DWLRQ LV VXSSUHVVHG DV PXFKDVSRVVLEOH 1\ORQ0HVKPPDSHUWXUHLV XVHGWRVHSDUDWH]LUFRQLDEDOOVPP 1 9ROXPH ●0HVKILOWHU %HIRUH 14 12 10 8 6 4 2 0 0.01 $IWHU6(0LPDJH[. 3DUWLFOH6L]H'LVWULEXWLRQ %HIRUH 0.1 $IWHU 1 10 100 3DUWLFOH6L]HѥP 1000 3000 In Response to Many Needs 1DQR3XOYHUL]HU 13 ,Q5HVSRQVHWR0DQ\1HHGV $IWHUUHSHDWHGFKDOOHQJHV We present NP-100 with confidence to fulfill your needs in the field of pulverization. THINKY MIXER plays an active role in various areas nowadays, enabling us to interact with people in a wide range of fields. The development for NP-100 has started by a researcher who has been a user of THINKY MIXER, suggesting the possibility of pulverizing nano materials. The development from a brand new viewpoint brought constant challenges and difficulties. With many researchers assistance and cooperation, we could overcome numerous hardships and invented the unique and innovative pulverizer, NP-100. 8QLTXHDQGLQQRYDWLYHSXOYHUL]HU NP-100 planetary centrifugal nano pulverizer has an optimal rotationrevolution ratio to maximize the collision energy of the pulverizing medium. It generates strong centrifugal force during rotation and revolution, and the pulverizing medium accelerates to crush the materials in the container. The significant improvement in pulverization efficiency allows ultralow volume (100 mg), fine crushing (100 nm), and short-time (2 minutes) pulverization which used to be regarded as impossible. Moreover, the mounted cooling mechanism can decrease the temperate inside the chamber to -20 $C, reducing the risk of contamination and keeping the crystal structure of compounds with low melting point during nano pulverization. Excellent operability provides simple operation; a batch system without troublesome cleaning and a mesh filter to easily collect the medium after pulverization. Since NP-100 pulverizes both inorganic and organic materials and crushes a minimum amount of sample as needed, it is utilized as an essential tool for researches with high-cost/high-tech materials. NP-100 s NP-100 Nano Pulverizer areas of activities are expanding not only in medical but in various fields. ■)HDWXUHVRI13 1DQROHYHO SXOYHUL]DWLRQ 8OWUDORZ YROXPHPJ SXOYHUL]DWLRQ 6LJQLILFDQW UHGXFWLRQLQ SXOYHUL]DWLRQ WLPH (Pulverization time) Conventional mill 24 hours Several hours (DV\WRFROOHFW WKHSXOYHUL]HG PDWHULDO &KLOOHU HTXLSSHG /RZ UXQQLQJFRVWV Several tens minutes Several minutes 13 100 mg − 10 g……………………kg t (Batch Volume) 2 Principle of THINKY Planetary Centrifugal Pulverization 1DQR3XOYHUL]HU 13 3ULQFLSOHRI7+,1.<3ODQHWDU\&HQWULIXJDO3XOYHUL]DWLRQ 8QLTXHSODQHWDU\FHQWULIXJDOV\VWHP NP-100 is the revolutionary pulverizer that applies the same planetary centrifugal system as THINKY MIXER. The planetary centrifugal system consists of 2 axes where the container rotates counterclockwise while revolving clockwise at a certain radius around an axis. The pulverizing medium, zirconia balls that have excellent abrasion resistance are placed in the container, which then rotates and revolves at high speed to apply centrifugal force to the medium. The pulverizing medium with centrifugal force crushes against the material and the collision energy makes the material finer. Revolution Rotation 45 ° Zirconia ball Material )HDWXUHV ●7KHFRQWDLQHUWLOWV DQGVKHDU VWUHVVLVFRQFHQWUDWHGWRWKHERWWRP FRUQHURIWKHFRQWDLQHU ●+LJKVSHHGVSLQQLQJUHGXFHV SXOYHUL]DWLRQWLPH 3 The figure above is only an image. Advantages of NP-100 <Exceptional superiority> 1DQR3XOYHUL]HU 13 $GYDQWDJHVRI13([FHSWLRQDOVXSHULRULW\! 6KRUWWLPHSXOYHUL]DWLRQ ●6XSHULRULW\RI13 13 3ODQHWDU\FHQWULIXJDOV\VWHP 3ODQHWDU\EDOOPLOORIDGLIIHUHQWPDQXIDFWXUHU 8SULJKWEDWFKV\VWHP 1XPEHURIUHYROXWLRQV 0D[ USP 0D[USP 3XOYHUL]DWLRQWLPH PLQXWHVIRURUJDQLFFRPSRXQGVWR PLQXWHVIRULQRUJDQLFPDWHULDO PLQXWHV ●3XOYHUL]DWLRQWLPH ●3XOYHUL]DWLRQHQHUJ\ *IRUFH UHYROXWLRQD[LV 7LPH 1/16 or less 4 times 13 %DOOPLOO 13 %DOOPLOO 3XOYHUL]DWLRQHQHUJ\LVVLPLODUWR*IRUFH 6XSSUHVVLRQRIKHDWJHQHUDWLRQGXULQJSXOYHUL]DWLRQXVLQJFKLOOHU With chiller 7KHFRROHGFKDPEHUVXSSUHVVHV EXLOGXSKHDWGXULQJSXOYHUL]DWLRQ 7HPSHUDWXUHVLQVLGHWKHFKDPEHUE\WKHUPRJUDSK\ ●0DWHULDOSURSHUW\KDVOLWWOHRUQRHIIHFW ●6DIHW\RIWKHRSHUDWRU ●6XSSUHVVLQJDEUDVLRQRIWKHFRQWDLQHU ●&RQWLQXRXVRSHUDWLRQLVSRVVLEOH ●&RROGRZQWLPHQRWUHTXLUHGIRUWKHPDFKLQH ,PDJHRI)/,5( Without chiller 7KHFRROHGFKDPEHUEXLOGVXSKHDW GXULQJSXOYHUL]DWLRQ 7HPSHUDWXUHVLQVLGHWKHFKDPEHUE\WKHUPRJUDSK\ ●0DWHULDOSURSHUW\LVODUJHO\DIIHFWHG ●,QFUHDVHGFRQWDPLQDWLRQ ●+HDWJHQHUDWLRQLQWKHPDFKLQHLPSDLUVUHSURGXFLELOLW\ ●&RQWLQXRXVRSHUDWLRQLVLPSRVVLEOH ●&RROGRZQWLPHUHTXLUHGIRUWKHPDFKLQH ●3URFHVVWLPHWDNHVORQJHU ,PDJHRI)/,5( 4 Advantages of NP-100 <Exceptional superiority> 1DQR3XOYHUL]HU 13 $GYDQWDJHVRI13([FHSWLRQDOVXSHULRULW\! 6XSSUHVVLRQRIFRQWDPLQDWLRQ 13 3ODQHWDU\FHQWULIXJDOV\VWHP 3ODQHWDU\EDOOPLOO XSULJKWEDWFKV\VWHP ≥ &RQWDPLQDWHG]LUFRQLDFRQWHQWSSP 0HGLXPIHHGDPRXQW ●0HGLXPIHHGDPRXQW 9ROXPHUDWLR $SSUR[ )DFWRUVRI FRQWDPLQDWLRQ 0DWHULDOWHPSHUDWXUHULVH 6XSSUHVVLRQPHFKDQLVPHTXLSSHG 6XSSUHVVLRQPHFKDQLVPQRWHTXLSSHG PLQXWHV 3XOYHUL]DWLRQWLPH ≥ PLQXWHV 7KHVHYDOXHVDUHDFFRUGLQJWRRXUH[SHULPHQWV7KH\DOVRYDU\GHSHQGLQJRQWKHPDWHULDOV ●6XSSUHVVLQJPDWHULDOWHPSHUDWXUHULVH XVLQJFKLOOHU ●&RQWDPLQDWLRQ Impurity concentration SXOYHUL]DWLRQWLPH Pulverization time 1/16 or less %DOOPLOO 13 2UGLQDU\WHPSHUDWXUHHQYLURQPHQW &KLOOHUWXUQHGRII %DOOPLOODERXW ●5HGXFWLRQLQ JHQHUDWHG 1/1000 or less &HQYLURQPHQW &KLOOHUWXUQHGRQ 13PD[ 13 %DOOPLOO /RZYROXPHSXOYHUL]DWLRQ ●5'QHHGV ・(YDOXDWLRQVRIGLYHUVHPDWHULDOVҋSURSHUWLHV LQDVKRUWWLPH ● ,PDJHVRIPLQLPXPDPRXQWRIPDWHULDOUHTXLUHG IRUEDWFKSXOYHUL]DWLRQ ・(YDOXDWLRQZLWKXOWUDORZYROXPHFRXOGEH SURFHVVHGIRUUDUHDQGH[SHQVLYH PDWHULDOV 13 0LQLPXPPDWHULDOIHHGDPRXQW PJ Ball mill 0LQLPXPPDWHULDOIHHGDPRXQW 6HYHUDOWHQVRIJUDPV /RZUXQQLQJFRVW ●$PRXQWRI]LUFRQLDEDOOV ●&ROOHFWLRQUDWHRI]LUFRQLDEDOOV 13 5 %DOOPLOO 13 %DOOPLOO Pulverized / Deagglomerated Samples 1DQR3XOYHUL]HU 13 3XOYHUL]HG'HDJJORPHUDWHG6DPSOHV ■ (OHFWURGH0DWHULDOVIRU/LWKLXP,RQ%DWWHU\ ●3RVLWLYHHOHFWURGH0DWHULDO 3XOYHUL]DWLRQ/LWKLXP&DUERQDWH %HIRUH 100μm $IWHU 3DUDPHWHU USPPLQ &RPSRXQG J *ULQGLQJWRRO =LUFRQLDEDOO(φPP) J %HIRUH &RPSRXQG J *ULQGLQJWRRO =LUFRQLDEDOOφ PP→φ PP J ' ' ' %HIRUH $IWHU ■3DUWLFOHVL]HGLVWULEXWLRQ 3 μm (μm) ' ' ' %HIRUH $IWHU 1 10 100 3DUWLFOH6L]H (ѥm) $IWHU 1000 $IWHU USPPLQ &RPSRXQG J 0.1 %HIRUH 1 10 100 3DUWLFOH6L]H (ѥm) $IWHU *ULQGLQJWRRO =LUFRQLDEDOO(φPP) J %HIRUH ■3DUWLFOHVL]HGLVWULEXWLRQ 1μm 3DUWLFOH6L]H'LVWULEXWLRQ ●'HDJJORPHUDWLRQ7LWDQLXPR[LGH 3DUDPHWHU ' 10 9 8 7 6 5 4 3 2 1 0 0.01 9ROXPH 0.1 100μm 10μm (μm) ' $IWHU ' %HIRUH $IWHU 3DUWLFOH6L]H'LVWULEXWLRQ 3DUDPHWHU 3XOYHUL]LQJUSPPLQ &RROLQJ USPPLQ &RPSRXQG J *ULQGLQJWRRO =LUFRQLDEDOO(φPP) 35 J ■3DUWLFOHVL]HGLVWULEXWLRQ ' 2μm 18 16 14 12 10 8 6 4 2 0 0.01 %HIRUH $IWHU (μm) ' ' 3DUWLFOH6L]H'LVWULEXWLRQ 9ROXPH 9ROXPH $IWHU 3DUWLFOH6L]H'LVWULEXWLRQ %HIRUH %HIRUH 0.1 $IWHU 1 10 100 3DUWLFOH6L]H (ѥm) 1000 ●1HJDWLYHHOHFWURGH0DWHULDO &DUERQEDVHGPDWHULDO 'HDJJORPHUDWLRQ &DUERQ%ODFN 3DUDPHWHU USPPLQ &RPSRXQG J *ULQGLQJWRRO =LUFRQLDEDOO(φPP)J 0.1 %HIRUH 1 10 100 3DUWLFOH6L]H (ѥm) $IWHU ●'HDJJORPHUDWLRQ,QRUJDQLFSLJPHQWV %HIRUH 1μm ■3DUWLFOHVL]HGLVWULEXWLRQ $IWHU (μm) ' ' %HIRUH $IWHU 3DUDPHWHU USPPLQ &RPSRXQG J *ULQGLQJWRRO =LUFRQLDEDOO(φPP) J ■3DUWLFOHVL]HGLVWULEXWLRQ 1μm 3DUWLFOH6L]H'LVWULEXWLRQ (μm) ' ' %HIRUH $IWHU ' ' 3DUWLFOH6L]H'LVWULEXWLRQ 12 10 9ROXPH 9ROXPH 16 14 12 10 8 6 4 2 0 10 μm (μm) ●3RVLWLYHHOHFWURGH0DWHULDO 3XOYHUL]DWLRQ/LWKLXP1LFNHODWH 14 12 10 8 6 4 2 0 0.01 3DUDPHWHU φPP=LUFRQLDEDOO 3XOYHUL]LQJ USPPLQ &RROLQJ USPPLQ φPP=LUFRQLDEDOO 3XOYHUL]LQJUSPPLQ &RROLQJUSPPLQ %HIRUH 9ROXPH 18 16 14 12 10 8 6 4 2 0 0.01 ●3XOYHUL]DWLRQ*ODVV ■3DUWLFOHVL]HGLVWULEXWLRQ 1μm ■ ,QRJDQLF0DWHULDOV 0.01 %HIRUH 0.1 $IWHU 1 10 3DUWLFOH6L]H (ѥm) 100 8 6 4 2 0 0.01 %HIRUH 0.1 $IWHU 1 10 3DUWLFOH6L]H (ѥm) 100 1000 3000 6 NP-100 Pulverized / Deagglomerated Samples ■ Medical and pharmaceutical materials ●Phenytoin (Low solubility compounds) Before Parameter 2000 rpm 2 min Parameter 2000 rpm 3 min Compound Phenytoin Compound Indomethacin Weight 100 mg Weight 100 mg Concentration 10 mg/ml Concentration 10 mg/ml Before Zirconia ball (φ0.1 mm) Grinding tool ■Particle size distribution After (SEM image x30 K) ●Indomethacin (Low solubility compounds) D50 Before 5.774 10.58 18.639 After 0.069 0.125 0.231 ■Particle size distribution D90 D10 Before After After (SEM image x30 K) Particle Size Distribution 14 12 10 8 6 4 2 0 0.01 Zirconia ball (φ0.1 mm) Grinding tool (μm) D10 (μm) D50 D90 3.89 12.894 37.092 0.069 0.126 0.237 Particle Size Distribution 12 Volume (%) 10 Volume (%) 0.1 Before Nano Pulverizer 1 After 10 Particle Size ( m) 100 8 6 4 2 0 0.01 1000 3000 0.1 Before 1 After 10 Particle Size ( m) 100 600 NP-100 Nano Particle Formation of Low Melting Point Compounds For nano pulverization of low melting point compound, control of both excessive pulverization energy and heat generation is essential in order to reduce amorphous particles. NP-100 has been proven to conduct nano pulverization of low melting point compounds by decreasing the rotation speed, using the cooling mechanism to achieve a low temperature environment at -20 ° C to cool the zirconia container effectively, and selecting the best solvent for the compound. ■ Crystallinity evaluation method after pulverization Crystallinity: Powder X-ray diffraction Melting point 115 ℃ Verification sample 〈Compound〉100 mg 〈Medium〉 (3) Probucol Melting point 125 ℃ 〈Temperature before and after pulverization〉 6.3 ℃ to 20.3 ℃ D50: 0.108 ± 0.004 μm D90: 0.186 ± 0.004 μm (N=3) Particle size(μm) : Original bulk : Pulverized bulk 2 θ(° ) : Original bulk : Pulverized bulk Temperature (℃) Intensity(cps) 2 θ(° ) Particle size(μm) : Original bulk : Pulverized bulk : Original bulk : Pulverized bulk : Original bulk : Pulverized bulk Temperature (℃) Reference paper:Nano-pulverization of poorly water soluble compounds with low melting points by a rotation/revolution pulverizer K.Yuminoki, M.Takeda, K.Kitamura, S.Numata, K.Kimura, T.Takatsuka, N.Hashimoto Journal of pharmaceutical sciences 103:3772-3781, 2014 7 φ0.1 mm, 2.5 g 0.3 % MC solution: 0.5 ml (SDS added)→ 9.5 ml D50: 0.131 ± 0.002 μm D90: 0.312 ± 0.024 μm (N=3) : Original bulk : Pulverized bulk Temperature (℃) DTA(uV) Flurbiprofen φ0.1 mm, 2.5 g 0.3 % MC solution: 0.5 ml → 9.5 ml 〈Temperature before and after pulverization〉 0 ℃ to 15.5 ℃ : Original bulk : Pulverized bulk : Original bulk : Pulverized bulk (TG / DTA) 2 θ(° ) Particle size(μm) Intensity(cps) Verification sample 〈Compound〉100 mg 〈Medium〉 (2) D50:0.129 ± 0.006 μm D90:0.508 ± 0.340 μm (N=3) Intensity(cps) 80 ℃ Volume(%) Melting point Volume(%) Fenofibrate φ0.1 mm, 2.5 g 0.3 % MC solution: 0.5 ml → 9.5 ml 〈Temperature before and after pulverization〉 0 ℃ to 9.3 ℃ : Original bulk : Pulverized bulk DTA(uV) (PXRD) Representative diameters: D50 and D90 ( m) Verification sample 〈Compound〉100 mg 〈Medium〉 (1) Crystallinity: Thermogravimetric and differential thermal analyzer DTA(uV) Particle size distribution: Laser diffraction Volume(%) 低 化合 物のナ 粒子Melting 化 Pulverized / Deagglomerated Samples / Nano Particle ofノLow Point Compounds Pulverized / Deagglomerated samples / 融 点Formation Nano Pulverizer Operation Nano Pulverizer NP-100 Operation ■Precool before pulverization Dummy weight Temperature Indicator UP/DOWN ● Cooling time in the chamber Atmosphere temperature(℃) Mode switch and SET UP CHILLER ON/OFF Time (minutes) Approx. time to cool to -20 °C Cup holder ■ Temperature indication : ≈30 minutes (Temperature of the chamber interior atmosphere) ■ Cup holder : ≈60 minutes Counter balance adjustment dial ■ Basic operation (Pulverization) 45° Solvent Wet pulverization Add solvent Materials Pulverization Mixing 400 rpm, 1 min MILL/MIX Mode Zirconia ball MILL/MIX Mode ■ Basic operation (Separation of media) Revolution Mesh filter Separating Media 2000 rpm, 1 min Dispersion 400 rpm, 1 min CLEAN MEDIA Mode MILL/MIX Mode 8 Users’ Voice / Column Nano Pulverizer NP-100 Users’ Voice / Column ■Users’ voice NP-100 nano pulverizer is essential for the study of next-generation batteries important along with scaling up is enhancement The conventional porous carbon electrodes of battery performance. I study exponential mentioned before were thick but had a problem improvement in flow battery performance by of long travel distance of ions, which limited the efficient supply of electrolytes to porous performance improvement. However, thinner carbon electrodes so that the phase interfaces electrodes had smaller ion reaction areas. Then, formed by the electrodes and the electrolyte a compact carbon layer is formed on the surfaces can be used to the limit. of the thin electrodes to increase the surface Trigger to adopt NP-100 and the area of the use area and ensure sufficient reaction area, Shohji Tsushima I had used THINKY MIXER before for preparation particles. When the carbon is placed on the Professor, Doctor (Engineering) Department of Mechanical Engineering, Graduate School of Engineering, Osaka University of electrode material slurries of polymer electrolyte electrodes, the carbon and solvent are prepared fuel cells. Before that, a mortar was used for like ink and applied by an inkjet printer with small manual mixing. Someone introduced THINKY nozzles. Therefore, the carbon particle sizes need MIXER as the de facto standard and I adopted it. to be kept fine, and NP-100 fully works with it. The variation in the finish among operators Research overview In addition, the capability of ultralow-volume was eliminated, and the efficiency of experiments processing, the cooling function, and excellent was improved remarkably. Then, I initiated the The current major objects of study are flow reproducibility also match the needs. I continue study of flow cells as a member of Phase Interfaces batteries (redox flow batteries) and polymer to make full use of this equipment to contribute for Highly Efficient Energy Utilization Project electrolyte fuel cells. Flow batteries can easily to the research and development of future energy of JST Strategic Basic Research Programs Sakigake, be scaled up, and they are expected to become devices. and NP-100 was adopted for deagglomerating a large-scale power storage device. What is and pulverizing the electrode material carbon. achieving both thinness and performance. NP-100 is used to deagglomerate the carbon ■Column NP-100 joint developer’s untold story of the development the suspended drug to animals, and it is most important to create a uniform suspension because uneven suspensions do not administer constant doses of the drug, causing variations in the data. Compared with conventional stirrer mixing, THINKY MIXER is easy and can prepare a uniform suspension in a short time. I proposed that THINKY MIXER should be used for safety studies in the laboratories of Pfizer in each country, Naofumi Hashimoto Professor, Doctor (Pharmacy) Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Setsunan University Development of NP-100 I started using THINKY MIXER more than ten years ago to prepare suspensions for safety studies at the Research Laboratories of Pfizer Inc., where I worked at the time. Safety studies are tests to examine adverse effects and toxicity by feeding 9 and it was accepted. On the other hand, my subordinate conducted an experiment to obtain finer particles by stirring the drug suspension, and I thought the beads put in THINKY MIXER could crush the drug finer and quicker. I tried it to achieve pulverization of the drug from several hundred microns to several microns. The operation duration, which used to be a whole day, was shortened to several minutes. After that, the Research Laboratories closed, and I moved to the university to continue research, as well as promote the development of nano pulverizers together with THINKY. Major advantages to pulverize the drug into nano particles Nano particles of the drug have exponentially increased the total surface area of the powder, leading to higher dissolution rates and better absorption from the gastrointestinal tract after oral administration. Forming nano particles was a very effective method for drugs with high pharmacological activity and difficult dissolution in water, which puzzled researchers at that time. In addition to the improvement in absorbability of oral administration, pulverization to 200 nanometers or less enabled application to various routes, including ocular instillation, transdermal, intravenous and intramuscular administration. While a larger dose may cause adverse effects, such as variations in absorbability and side effects, use of nano particles eliminates the need for an excess administration of drugs and achieves medicinal action with a smaller dose than conventional doses. Nano particle drug formulation leads to the development of safer medicines and may increase dramatically in the future. I am very glad to know that this equipment is now used in different fields. Latest Optional Tools / Our Support System Nano Pulverizer NP-100 Latest Optional Tools / Our Support System ■ Latest optional tools Zirconia containers to pulverize minimum of 10 ml material ● Simultaneous process of two samples in 10 ml zirconia containers The two data overlaps each other. 10 ml zirconia container lid 10 ml zirconia containers x2 µ 10 ml zirconia container adapter 10 ml zirconia container set ●Maximum liquid feed amount: 10 ml amount of pulverization: 10 to 100 mg ●Recommended recipe available (pulverizing phenytoin) ●Recommended Comparison with the standard container (80 ml container) * The particle sizes of the two samples are uniform. ●Particle size difference when pulverizing 100 mg or less material in 10 ml zirconia container (red) and 80 ml standard container (green) µ * Compared with the standard container, the 10 ml zirconia container tends to have more uniform pulverized particle sizes. The reason is that the small diameter of the 10 ml container increases frequencies of collisions between the balls and the material to contribute to pulverization efficiency. ●Increased frequency of collision between balls and material to improve pulverization efficiency ●Simultaneous process of two samples to increase efficiency ●Tendency of more uniform particle sizes after pulverizing 100 mg or less ●Less heat generation during pulverization ●Reduced material loss due to adhesion of the container ■ Our Support System Two secure support systems After-sales support If you have any problems with a product, please contact us. Application engineering THINKY s professional application team supports parameter settings Please contact THINKY CORPORATION Email: [email protected] THINKY http://www.thinkymixer.net/ for customers. Before demonstration of pulverization, implementation of preliminary examination enables smooth presentation of the demonstration. Contact THINKY CORPORATION listed on the back cover. THINKY continues to assist customers with our full support system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o¡$o+¡$ 9LJVTTLUKLKJVU[HPULY 1VMWFSJ[BUJPODPOUBJOFSTFU;JSDPOJB .FEJBTFQBSBUJPOTFU464 4LKPHMVYW\S]LYPaPUN ;JSDPOJBCBMM .BYJNVNRVBOUJUZH.BYJNVNTJ[FNN =VS\TLVMTH[LYPHS NHoH 4H_PT\TSPX\PK]VS\TL NM 4H_PT\TNYVZZ^LPNO[ H :\WWS`WV^LY =VS[HNL 4JOHMFQIBTF"$7)[ *VUZ\TW[PVU WV^LY "UTUBOECZ7"<)[> %VSJOHTUBOECZPQFSBUJPO7"<)[> %VSJOHPQFSBUJPO.BY7" >VYRPUNHTIPLU[LU]PYVUTLU[ o¡$o%3)XJUIPVUDPOEFOTBUJPO ,_[LYUHSKPTLUZPVUZ )¨8¨%NN 4HPU\UP[THZZ "QQSPYLH 625 mm 785 mm 7YVK\J[ 600 mm Product Specification 7YVK\J[HWWLHYHUJLZWLJPMJH[PVUZTH`JOHUNL^P[OV\[UV[PJL )RUUHTXHVWVFRQFHUQLQJGHPRQVWUDWLRQV DQGHYDOXDWLRQWHVWLQJSOHDVHFRQWDFW 7+,1.<&25325$7,21 )RUWKHODWHVWLQIRUPDWLRQDERXWSURGXFWV DQGH[KLELWLRQVYLVLW ,THPS!PUMV'[OPUR`TP_LYUL[ O[[W!^^^[OPUR`TP_LYUL[ or the sales agent below Sales agent “NIPPON MONOZUKURI”INNOVATOR H e a d q u a r t e r s : 2-16-2 Sotokanda, Chiyoda-ku, Tokyo 101-0021 Phone : +81-3-5207-2713 Fax : +81-3-5289-3281 THINKY USA Inc. : 23151 Verdugo Drive, Suite 107 Laguna Hills, CA92653, USA THINKY CHINA: East building, HaiAn Kafunuo Mansion, Shennan road, Qianhai road, Nanshan district, Shenzhen 9LWYVK\J[PVUZ[YPJ[S`WYVOPIP[LK4HY