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chapter 19 Student: ___________________________________________________________________________ 1. Choose the following that best characterizes the formation of uncontrolled division of cells or cancer. A.mutations in DNA for the protein which activates repair enzymes B.mutation in genes for inhibiting the cell cycle C.mutations in proto-oncogenes/tumor suppressor genes D.active telomerase E.All of the choices are correct. 2. Normal cells typically divide 60-70 times while cancer cells: A.divide an unlimited number of times B.divide twice that amount C.may divide 60-70 times D.are unable to divide 3. Cancer cells have abnormal nuclei because: A.the nuclear membrane is malformed B.there are too many nucleoli C.the chromosomes are abnormal, often showing gene amplification D.of the disappearance of chromosomes, making the nucleus smaller 4. What is the function of telomerase? A.rebuild telomere sequences B.destroy telomere sequences C.connect different telomere sequences D.separate different telomere sequences 5. Choose the following that is NOT a characteristic of cancer cells. A.They do not differentiate. B.They invade nearby tissues if malignant. C.They secrete angiogenic growth factors. D.They display contact inhibition. 1 6. When cancer cells metastasize: A.tumors release growth factors B.tumors spread throughout the body C.tumors have nondifferentiated cells D.tumors get larger and larger 7. Cancer cells are able to move about the body when: A.T cells attach and carry the cancer cells to different tissues B.they produce proteinase which degrades the basement membrane allowing invasion of other tissues C.telomeres attach to the basement membrane and pull cancer cells through to other tissues D.None of the choices are correct. 8. A mutation in the Bax gene results in: A.less likelihood of apoptosis B.less Bax protein present C.possible tumor formation D.All of the choices are correct. 9. Ras oncogenes A.produce cyclin. B.activate repair enzymes. C.promote apoptosis. D.activate cyclin. 10. Which of the following mutated genes ultimately results in increased cyclin activity? A.p16 B.Ras C.p53 D.both p16 and Ras 11. Stimulatory pathways are: A.proto-oncogenes B.tumor suppressor genes 2 12. Inhibitory pathways are: A.proto-oncogenes B.tumor suppressor genes 13. Cancer causing genes are A.apoptosis B.leukemia C.oncogenes 14. Programmed cell death is: A.apoptosis B.leukemia C.oncogenes 15. Cancer of blood forming cells is A.apoptosis B.leukemia C.oncogenes 16. What are telomeres? A.specific proteins B.repair enzymes C.special repetitive DNA end sequences D.signalling chemicals 17. What is the role of telomeres? A.protect chromosome ends B.act as molecular handles C.repair enzymes D.unfold chromosomes 3 18. An oncogene: A.is the gene that causes p53 to be readily available B.is a gene that causes a cell to become differentiated C.is a gene that codes for the lipid component of the plasma membrane D.can make cyclin available at all times 19. The regulatory network in cells that controls cell growth includes: A.growth factor receptors in the plasma membrane B.signaling proteins in the cytoplasm C.genes in the nucleus D.All of the choices are correct. 20. Which is NOT associated with the development of cancer? A.plasma membrane receptors B.the Golgi apparatus C.cytoplasmic enzymes D.genes in the nucleus 21. Which is NOT associated with the development of cancer? A.plasma membrane receptors B.the Golgi apparatus C.cytoplasmic enzymes D.genes in the nucleus 22. A tumor-suppressor gene: A.is a cancer-causing gene B.is a gene that codes for inhibitory proteins that prevent cell division and promote apoptosis C.is a gene that causes myeloma in muscle cells D.is a gene that stops a tumor once it has developed 23. During the formation of cancer, which of the following occurs? A.initiation B.promotion C.progression D.All of the choices are correct. 4 24. The uncontrolled division of cells is called: A.cancer B.mitosis C.mutation D.metastasis 25. An accumulation of cancer cells is called a: A.bolus B.diverticulum C.tumor D.metastasis 26. The development of cancer is called: A.oogenesis B.carcinogenesis C.apoptosis D.metastasis 27. Forming blood vessels is: A.metastasis B.apoptosis C.angiogenesis 28. Cell death is: A.metastasis B.apoptosis C.angiogenesis 29. Which type of tumor is usually encapsulated and noninvasive? A.benign tumor B.malignant tumor 5 30. Cancers in blood-forming cells are called: A.lymphomas B.melanomas C.carcinomas D.leukemias 31. A tumor developing in lymphatic tissues is a: A.lymphoma B.carcinoma C.sarcoma D.leukemia 32. A tumor arising in epithelial tissues is a: A.lymphoma B.carcinoma C.sarcoma D.leukemia 33. Which of the following changes in DNA? A.mutagen B.carcinogen C.Both choices are correct. 34. Which behaviors are NOT associated with cancer development? A.smoking cigars and drinking alcohol B.poor sleeping habits C.exposure to radon D.a high-fat diet 35. Which of these seems to play a role in the development of cancer? A.heredity B.carcinogens C.mutations D.All of the choices are correct. 6 36. Which of these is considered a carcinogen or carcinogenic? A.radiation B.toxic chemicals C.viruses D.All of the choices are correct. 37. Regular Pap smears are credited with preventing what percentage of cervical cancer deaths? A.10% B.30% C.65% D.90% 38. Magnetic resonance imaging is particularly useful for determining the location of tumors: A.in the blood B.of the cervix C.of the brain and spinal cord D.lymphatic tumors 39. Use of taxol to treat ovarian cancer is an example of what type of treatment? A.gene therapy B.antimetastatic drugs C.chemotherapy D.antihormone therapy 40. Chemotherapy may not be an effective treatment for some cancers because: A.effective therapies have not been discovered B.some cancer cells may be resistant C.cancers caused by viruses are nonsusceptible D.chemotherapy is a new therapy and not yet proven its effectiveness 41. Which of these diagnostic procedures is used for breast cancer? A.mammography B.pap smear C.sigmoidoscopy D.stool blood test 7 42. Which of these diagnostic procedures is used for colon cancer? A.colonoscopy B.CEA blood test C.white cell count D.both a colonoscopy and CEA blood test 43. Which of these is NOT associated with the presence of a cancer? A.a sore that does not heal B.a lump in the breast C.changes in sleeping habits D.indigestion/change in bowel habits 44. The American Cancer Society recommends breast self-exams and testicular self-exams every: A.day B.month C.6 months D.year 45. Which of the following has been proposed as future therapy? A.cancer vaccines B.monoclonal antibodies C.p53 gene therapy/induced tumor apoptosis D.angiogenesis inhibition E.All of the choices are correct. 46. Which vegetables are associated with cancer prevention? A.peas and string beans B.potatoes and rice C.cabbage and broccoli D.mushrooms and peppers 8 chapter 19 Key 1. Choose the following that best characterizes the formation of uncontrolled division of cells or cancer. a. b. c. d. E mutations in DNA for the protein which activates repair enzymes mutation in genes for inhibiting the cell cycle mutations in proto-oncogenes/tumor suppressor genes active telomerase All of the choices are correct. Mader - 019 Chapter... #1 2. Normal cells typically divide 60-70 times while cancer cells: A b. c. d. divide an unlimited number of times divide twice that amount may divide 60-70 times are unable to divide Mader - 019 Chapter... #2 3. Cancer cells have abnormal nuclei because: a. b. C d. the nuclear membrane is malformed there are too many nucleoli the chromosomes are abnormal, often showing gene amplification of the disappearance of chromosomes, making the nucleus smaller Mader - 019 Chapter... #3 4. What is the function of telomerase? A b. c. d. rebuild telomere sequences destroy telomere sequences connect different telomere sequences separate different telomere sequences Mader - 019 Chapter... #4 1 5. Choose the following that is NOT a characteristic of cancer cells. a. b. c. D They do not differentiate. They invade nearby tissues if malignant. They secrete angiogenic growth factors. They display contact inhibition. Mader - 019 Chapter... #5 6. When cancer cells metastasize: a. B c. d. tumors release growth factors tumors spread throughout the body tumors have nondifferentiated cells tumors get larger and larger Mader - 019 Chapter... #6 7. Cancer cells are able to move about the body when: a. T cells attach and carry the cancer cells to different tissues B they produce proteinase which degrades the basement membrane allowing invasion of other tissues c. telomeres attach to the basement membrane and pull cancer cells through to other tissues d. None of the choices are correct. Mader - 019 Chapter... #7 8. A mutation in the Bax gene results in: a. b. c. D less likelihood of apoptosis less Bax protein present possible tumor formation All of the choices are correct. Mader - 019 Chapter... #8 2 9. Ras oncogenes a. b. c. D produce cyclin. activate repair enzymes. promote apoptosis. activate cyclin. Mader - 019 Chapter... #9 10. Which of the following mutated genes ultimately results in increased cyclin activity? a. b. c. D p16 Ras p53 both p16 and Ras Mader - 019 Chapter... #10 11. Stimulatory pathways are: A proto-oncogenes b. tumor suppressor genes Mader - 019 Chapter... #11 12. Inhibitory pathways are: a. proto-oncogenes B tumor suppressor genes Mader - 019 Chapter... #12 13. Cancer causing genes are a. apoptosis b. leukemia C oncogenes Mader - 019 Chapter... #14 3 14. Programmed cell death is: A apoptosis b. leukemia c. oncogenes Mader - 019 Chapter... #15 15. Cancer of blood forming cells is a. apoptosis B leukemia c. oncogenes Mader - 019 Chapter... #16 16. What are telomeres? a. b. C d. specific proteins repair enzymes special repetitive DNA end sequences signalling chemicals Mader - 019 Chapter... #17 17. What is the role of telomeres? A b. c. d. protect chromosome ends act as molecular handles repair enzymes unfold chromosomes Mader - 019 Chapter... #18 18. An oncogene: a. b. c. D is the gene that causes p53 to be readily available is a gene that causes a cell to become differentiated is a gene that codes for the lipid component of the plasma membrane can make cyclin available at all times Mader - 019 Chapter... #19 4 19. The regulatory network in cells that controls cell growth includes: a. b. c. D growth factor receptors in the plasma membrane signaling proteins in the cytoplasm genes in the nucleus All of the choices are correct. Mader - 019 Chapter... #20 20. Which is NOT associated with the development of cancer? a. B c. d. plasma membrane receptors the Golgi apparatus cytoplasmic enzymes genes in the nucleus Mader - 019 Chapter... #22 21. Which is NOT associated with the development of cancer? a. B c. d. plasma membrane receptors the Golgi apparatus cytoplasmic enzymes genes in the nucleus Mader - 019 Chapter... #22 22. A tumor-suppressor gene: a. B c. d. is a cancer-causing gene is a gene that codes for inhibitory proteins that prevent cell division and promote apoptosis is a gene that causes myeloma in muscle cells is a gene that stops a tumor once it has developed Mader - 019 Chapter... #23 23. During the formation of cancer, which of the following occurs? a. b. c. D initiation promotion progression All of the choices are correct. Mader - 019 Chapter... #24 5 24. The uncontrolled division of cells is called: A b. c. d. cancer mitosis mutation metastasis Mader - 019 Chapter... #25 25. An accumulation of cancer cells is called a: a. b. C d. bolus diverticulum tumor metastasis Mader - 019 Chapter... #26 26. The development of cancer is called: a. B c. d. oogenesis carcinogenesis apoptosis metastasis Mader - 019 Chapter... #27 27. Forming blood vessels is: a. metastasis b. apoptosis C angiogenesis Mader - 019 Chapter... #28 28. Cell death is: a. metastasis B apoptosis c. angiogenesis Mader - 019 Chapter... #29 6 29. Which type of tumor is usually encapsulated and noninvasive? A benign tumor b. malignant tumor Mader - 019 Chapter... #31 30. Cancers in blood-forming cells are called: a. b. c. D lymphomas melanomas carcinomas leukemias Mader - 019 Chapter... #33 31. A tumor developing in lymphatic tissues is a: A b. c. d. lymphoma carcinoma sarcoma leukemia Mader - 019 Chapter... #34 32. A tumor arising in epithelial tissues is a: a. B c. d. lymphoma carcinoma sarcoma leukemia Mader - 019 Chapter... #35 33. Which of the following changes in DNA? a. mutagen b. carcinogen C Both choices are correct. Mader - 019 Chapter... #40 7 34. Which behaviors are NOT associated with cancer development? a. B c. d. smoking cigars and drinking alcohol poor sleeping habits exposure to radon a high-fat diet Mader - 019 Chapter... #45 35. Which of these seems to play a role in the development of cancer? a. b. c. D heredity carcinogens mutations All of the choices are correct. Mader - 019 Chapter... #46 36. Which of these is considered a carcinogen or carcinogenic? a. b. c. D radiation toxic chemicals viruses All of the choices are correct. Mader - 019 Chapter... #47 37. Regular Pap smears are credited with preventing what percentage of cervical cancer deaths? a. b. c. D 10% 30% 65% 90% Mader - 019 Chapter... #53 38. Magnetic resonance imaging is particularly useful for determining the location of tumors: a. b. C d. in the blood of the cervix of the brain and spinal cord lymphatic tumors Mader - 019 Chapter... #55 8 39. Use of taxol to treat ovarian cancer is an example of what type of treatment? a. b. C d. gene therapy antimetastatic drugs chemotherapy antihormone therapy Mader - 019 Chapter... #56 40. Chemotherapy may not be an effective treatment for some cancers because: a. B c. d. effective therapies have not been discovered some cancer cells may be resistant cancers caused by viruses are nonsusceptible chemotherapy is a new therapy and not yet proven its effectiveness Mader - 019 Chapter... #58 41. Which of these diagnostic procedures is used for breast cancer? A b. c. d. mammography pap smear sigmoidoscopy stool blood test Mader - 019 Chapter... #60 42. Which of these diagnostic procedures is used for colon cancer? a. b. c. D colonoscopy CEA blood test white cell count both a colonoscopy and CEA blood test Mader - 019 Chapter... #61 43. Which of these is NOT associated with the presence of a cancer? a. b. C d. a sore that does not heal a lump in the breast changes in sleeping habits indigestion/change in bowel habits Mader - 019 Chapter... #62 9 44. The American Cancer Society recommends breast self-exams and testicular self-exams every: a. B c. d. day month 6 months year Mader - 019 Chapter... #63 45. Which of the following has been proposed as future therapy? a. b. c. d. E cancer vaccines monoclonal antibodies p53 gene therapy/induced tumor apoptosis angiogenesis inhibition All of the choices are correct. Mader - 019 Chapter... #70 46. Which vegetables are associated with cancer prevention? a. b. C d. peas and string beans potatoes and rice cabbage and broccoli mushrooms and peppers Mader - 019 Chapter... #73 10 chapter 19 Summary Category Mader - 019 Chapter... 1 # of Questions 46