Download Tuesday

Tuesday
May 7, 2013
LIFE-CHANGING RESEARCH
MAY 5 – 9 | SEATTLE
188
364 Hot Topics in Infection and Immunity [IM]
#3665-3671
307 Glaucoma Epidemiology: Teasing Out
324 General
Mechanisms and Understanding the Burden Business
[CL] #2651-2657
Meeting
615-617
TCC LL 4/5
308 Binocular Vision and Stereopsis [VI]
#2658-2664
334 Clinical Aspects of Motion Perception —
Minisymposium [VI, EY, GL] #3210-3216
360 Microglia in Retinal Disease: A Cellular
Target for Therapy? — SIG [RC, AP, RE, IM]
351 Nanotechnology and Regenerative
Medicine Group: Minimally Invasive Biometric
Technology as a Means to Improve Detection,
Understanding, and Treatment of Ocular
Disease [NT]
337 Neuro-Ophthalmology: Structural Imaging
Studies [EY] #3231-3237
TCC 305
354 Smartphones in Ophthalmology
336 Cell and Molecular Biology [CO] #32243230
310 Visual Behavior, Disease, and
Restoration [VN] #2672-2678
TCC 304
353 Global Health and Vision Research: The
Future of International Collaborations and
Impacts
370 Color Vision [VI] #3705-3710
372 Into the Blue: New Developments in
S-cone Visual Channels — Minisymposium
[VN] #3718-3723
371 Refractive Surgery [CO] #3711-3717
369 Pharmacological Targets for Eye Disease:
Present and Future [PH] #3698-3704
359 Emerging Strategies for In Vivo Cellular
and Molecular Imaging of Retinal Disease —
SIG [RE, AP, VI, RC, PH, IM, GL, BI]
335 Corneal Epithelium and Imaging III [CO]
#3217-3223
368 Epigenetics: Genes and Environment
—Minisymposium [CL, GEN] #3693-3697
367 Diabetic Retinopathy: Cell Biology [RC]
#3686-3692
358 Visual Function Clinical Trial Endpoints —
SIG [CL, GL, VI, RE]
357 Antioxidants and AMD: Into the
Mechanisms — SIG [RE, BI, VI, IM]
309 Dry Eye and Lacrimal Gland III [CO]
#2665-2671
333 Drug Delivery II [PH] #3203-3209
332 Risks Associated with AMD [RC]
#3196-3202
TCC 303
618-620
306 Protein Trafficking in Photoreceptors
and Interactions Between the Retina and
RPE [RC] #2644-2650
611-614
366 Lens Proteins/Transport [LE] #3679-3685
355 Translational Aspects of Anti(lymph)
Angiogenic Therapy at the Ocular Surface —
SIG [CO, AP, PH, IM, GL, CL]
331 Lens Development [LE] #3189-3195
329 Inflammatory Tissue Damage and
Immunoregulation [IM] #3175-3181
305 Clinical Application of Ocular Imaging
[MOI] #2637-2643
606/607
363 AMD: Morphology and Novel Risk Factors
[RE] #3658-3664
609
328 AMD: Long Term Outcomes and Safety of
Anti VEGF [RE] #3168-3174
304 Perimetry I [GL] #2630-2636
6E
384 ARVO/
Champalimaud
Award Lecture
7–8:15pm
ARVO Rocks!
Seattle Sheraton,
9pm–12Midnight
Networking Happy Hour,
Exhibit Halls, 4:30–6pm
Fifth Annual WEAVR
Luncheon
Room 301/302, 1–2:30pm
NAEVR Central,
Skybridge, 9am–5pm
Exhibit Halls, 11am–6pm
383 ARVO/Alcon
Keynote Series
362 Biochemistry and Regulation of Proteins in
AMD [BI] #3651-3657
365 Myopia: Molecular/Genetic Mechanisms
[AP] #3672-3678
327 Imaging: Advances in Imaging and
Diagnostic [RE] #3161-3167
303 Metabolomics and Lipidomics:
Metabolic Fingerprints Offer New
Insights into Disease Pathogenesis with
Potential for Life Changing Research —
Minisymposium [RE, CL] #2626-2629
6C
5:30–6:45pm
2:45–4:30pm
330 From Cytology to Proteomics: New
356 Endothelial Dysfunction: From
Insights into the Vitreous and Its Role in Ocular Pathophysiology to Treatment —SIG [CO]
Disease — Minisymposium [AP] #3182-3188
326 Biomechanics [GL] #3154-3160
302 Clinical Studies/Trials [GL] #2619-2625
6B
352 Clinician-Scientist Forum: How to Become
a Successful Clinician-Scientist
1–2:30pm
Workshop/SIG
608
325 Biochemical and Molecular Mechanisms of
Diabetic and Retinal Disease [BI] #3148-3153
301 Gene Regulation: Transcription and
Epigenetics [BI] #2612-2618
6A
Room
8:30–10:15am 10:15–10:55am
11am–12:45pm
Tuesday, May 7
189
Low Vision Rehabilitation [VI]
Macular Disease other than AMD I [RE]
Retinal Detachment I [RE]
Clinical and Translational Studies in
Ocular Infection and Immunity [IM, CL]
Posterior Segment Inflammation I [IM, RE]
Cataractogenesis [LE]
Cataract Surgery III [LE, CL]
Color Vision, Photoreceptor Function, Adaptation [VI, VN]
Anatomy [AP]
Corneal Surgery Non-refractive I [CO]
Corneal Surgery Refractive [CO]
313
314
315
316
317
318
319
320
321
322
323
(D0037-D0082)
(D0001-D0036)
(C0194-C0228)
(C0177-C0193)
(C0074-C0104)
(C0040-C0073)
(B0296-B0317)
(B0248-B0295)
(B0149-B0187)
(B0039-B0093)
(B0001-B0038)
(A0151-A0190)
(A0001-A0028)
Vitreoretinal Surgery II [RE]
Exome Sequencing: New Genes, Methods and
Databases [GEN]
Ganglion Cells, Visual Brain and Behavior [VN]
Circadian and Adaptational Modulation [VN]
Cones and Outer Retina [VI]
Corneal Surgery Non-refractive II and Keratoprosthesis [CO] #3456-3481
Glaucoma [CL]
Trabecular Meshwork II [GL]
Anterior Segment Imaging [MOI]
Vitreoretinal Imaging [MOI]
Strabismus: Detection and Quality of Life [EY]
340
341
342
343
344
345
346
347
348
349
350
#3639-3650
#3591-3638
#3568-3590
#3526-3567
#3482-3525
#3428-3455
#3415-3427
#3384-3414
#3345-3383
#3300-3344
#3272-3299
AMD: New Drugs, Delivery Systems, and
Mechanisms of Action [PH]
#3238-3271
Retinal Degeneration and Neuroprotection [RC]
(D0384-D0395)
(D0320-D0367)
(D0297-D0319)
(D0255-D0296)
(D0158-D0201)
(D0083-D0108)
(C0149-C0176)
(C0136-C0148)
(C0105-C0135)
(C0001-C0039)
(B0188-B0232)
(A0123-A0150)
(A0029-A0062)
ProgramBoard
Number
Number
339
Session
Title
#3102-3147
#3066-3101
#3031-3065
#3014-3030
#2983-3013
#2949-2982
#2927-2948
#2879-2926
#2840-2878
#2785-2839
#2747-2784
#2707-2746
#2679-2706
ProgramBoard
Number
Number
338
Session
Number
Gene Therapy [PH]
11am–12:45pm
Diabetic Retinopathy and Vascular Biology I [RC]
312
Session
Title
8:30–10:15am
311
Session
Number
Tuesday, May 7 n Posters
Lipids, Retinoids and Macular Pigments [BI]
AMD I, RE [RE]
Macular Miscellaneous [RE]
CNV [RE]
Corneal Wound Repair, Transparency I [CO]
Perimetry II [GL]
Retinoblastoma: Experimental and Clinical [AP]
Amblyopia: Detection, Treatment and Mechanisms [EY]
374
375
376
377
378
379
380
381
#3983-3999
#3967-3982
#3914-3966
#3865-3913
#3854-3864
#3839-3853
#3784-3838
#3756-3783
#3724-3755
(D0396-D0412)
(D0368-D0383)
(D0202-D0254)
(D0109-D0157)
(B0318-B0328)
(B0233-B0247)
(B0094-B0148)
(A0095-A0122)
(A0063-A0094)
ProgramBoard
Number
Number
4:30–5:30pm: All Posters — authors will be present at poster boards
4:30–6pm: Networking Happy Hour in Exhibit/Poster Halls
Poster board numbers indicate location:
Poster Area A and B = South Exhibit Hall; Poster Area C and D = North Exhibit Hall
Retinal Development I: Photoreceptors,
Retina and RPE [RC]
Session
Title
373
Session
Number
2:45–4:30pm
NOTES
NOTES
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
190
266
Tuesday – Papers/Minisymposium – 2612 – 2625
6A
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Biochemistry/Molecular Biology
301 Gene Regulation: Transcription
and Epigenetics
Moderators: Shiming Chen and Noriko Esumi
2612 — 8:30 Transcriptional and posttranscriptional regulation links RPE65, RLBP1,
and RGR in the RPE. Noriko Esumi1, T. Masuda1,
J. Wan1, K. J. Wahlin1, J. Iacovelli2, N. Wolkow2,
J. L. Dunaief2, D. J. Zack1, 3, J. Qian1. 1Wilmer
Eye Institute, Johns Hopkins Univ Sch of Med,
Baltimore, MD; 2F.M. Kirby Center for Molecular
Ophthalmology, Scheie Eye Institute, University
of Pennsylvania, Philadelphia, PA; 3Neuroscience,
Molecular Biology and Genetics, and Institute of
Genetic Medicine, Johns Hopkins Univ Sch of Med,
Baltimore, MD *CR
2614 — 9:00 Transcription and splicing
associated protein NonO/p54nrb regulates rod
specific genes including rhodopsin and their
regulators required for rod differentiation
and homeostasis. Sharda P. Yadav, H. Hao, M. I.
Kautzmann, M. Brooks, J. Nellissery, A. Swaroop.
National Eye Institute, National Institutes of Health,
Bethesda, MD
2615 — 9:15 Correlating Whole Genome DNA
Methylation Patterns with Retinal Expression
and Alternative Splicing. Jiang Qian, J. Wan, V.
F. Oliver, D. J. Zack, S. L. Merbs. Department of
Ophthalmology, Johns Hopkins School of Medicine,
Baltimore, MD *CR
2616 — 9:30 Histone marks predict cell
plasticity of the adult human retinal pigment
epithelium. Timothy A. Blenkinsop1, A. RadaIglesias2, J. Wysocka2, S. Temple1. 1Macular
Degeneration Program, Neural Stem Cell Institute,
Rensselaer, NY; 2Developmental Biology, Stanford
University, Stanford, CA *CR
2617 — 9:45 The MLL1 Histone
Methyltransferease is Essential for Development
of Photoreceptor Function. Diana S. Brightman,
R. Suzuki, S. Chen. Ophthalmology and Visual
Sciences, Washington University in St. Louis, St.
Louis, MO
6B
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Glaucoma
302 Clinical Studies/Trials
Moderators: Mae O. Gordon and Neeru Gupta
2619 — 8:30 The United Kingdom Glaucoma
Treatment Study (UKGTS): baseline
characteristics and main outcomes. David F.
Garway-Heath1, G. Lascaratos1, C. Bunce1, D.
P. Crabb2, R. A. Russell2, A. Shah1, K. Suzuki1, E.
White1, F. Amalfitano1. 1NIHR Biomedical Research
Centre at Moorfields Eye Hospital NHS Foundation
Trust and UCL Institute of Ophthalmology, London,
United Kingdom; 2Department of Optometry and
Visual Science, City University, London, United
Kingdom *CR, f
2620 — 8:45 Canadian Glaucoma Study 4:
Neuroretinal Rim Area Change in Patients with
Visual Field-based Endpoints and Interventions.
Rizwan Malik1, 6, N. O’Leary1, 7, F. S. Mikelberg2,
G. A. Balazsi3, R. P. LeBlanc1, M. R. Lesk4, M.
T. Nicolela1, G. E. Trope5, B. C. Chauhan1.
1
Ophthalmology and Visual Sciences, Dalhousie
University, Halifax, NS, Canada; 2Ophthalmology
and Visual Sciences, University of British Columbia,
Vancouver, BC, Canada; 3Ophthalmology, McGill
University, Montreal, QC, Canada; 4Université de
Montréal, Montreal, QC, Canada; 5Ophthalmology
and Visual Sciences, University of Toronto, Toronto,
ON, Canada; 6NIHR Biomedical Research Centre
for Ophthalmology at Moorfields Eye Hospital
NHS Foundation Trust and UCL Institute of
Ophthalmology, London, United Kingdom; 7Centre
for Biostatistics, Institute of Population Health,
School of Medicine, University of Manchester,
Manchester, United Kingdom *CR, f
2621 — 9:00 A Randomized, Phase II Study of
Trabodenoson (INO-8875) in Adults with Ocular
Hypertension (OHT) or Primary Open-Angle
Glaucoma (POAG). Jonathan S. Myers1, K. N.
Sall2, H. DuBiner3, C. Brickman4, N. Slomowitz4,
W. McVicar4, R. Baumgartner4. 1Glaucoma, Wills
Eye Institute, Philadelphia, PA; 2Sall Research
Medical Center, Inc., Artesia, CA; 3Eye Care
Center Management, GA, Morrow, GA; 4Inotek
Pharmaceutical Corporation, Lexington, MA *CR, f
2622 — 9:15 Association of poor eyedrop
instillation technique and faster rate of visual
field progression in patients under chronic
glaucoma medical therapy. Jimena Schmidt1, 2, A.
Gerhard1, 2, M. Sanchez2, P. Musa1, D. S. Friedman3,
E. A. Maul1, 2. 1Ophthalmology Department,
Pontificia Universidad Catolica de Chile, Santiago,
Chile; 2Ophthalmology Department, Hospital
Sotero del Rio, Santiago, Chile; 3Ophthalmology
Department, Wilmer Eye Institute/ John Hopkins,
Baltimore, MD *CR
2623 — 9:30 Non-adherence in glaucoma and
its association with satisfaction of glaucoma
and medication information. Heidi Cate1, 2, D.
Bhattacharya2, A. Clark3, R. Fordham3, R. Holland3,
D. C. Broadway1. 1Glaucoma Research Unit,
Ophthalmology, Norfolk and Norwich University
Hospital Foundation Trust, Norwich, United
Kingdom; 2School of Pharmacy, University of
East Anglia, Norwich, United Kingdom; 3Norwich
Medical School, University of East Anglia,
Norwich, United Kingdom f
2624 — 9:45 Protective effects of JNK
inhibition in retinal ganglion cells and in retinal
ischemia/reperfusion injury. Byung-Jin Kim1, Y.
Liu1, S. Silverman1, R. J. Wordinger1, R. T. Libby2, I.
Pang1, A. F. Clark1. 1The North Texas Eye Research
Institute, Univ of North Texas Hlth Sci Ctr, Fort
Worth, TX; 2Department of Ophthalmology,
University of Rochester Medical Center, Rochester,
NY *CR
2625 — 10:00 Topical administration of MRZ99030, a β-amyloid aggregation modulator,
protects retinal ganglion cells and axons in a
rodent model of glaucoma. Andreas Gravius1,
K. Klein1, L. A. Levin2, W. Lagreze3, N. Wegener1,
W. Danysz1. 1Merz Pharmaceuticals, Frankfurt,
Germany; 2McGill University, Montreal, QC,
Canada; 3University of Freiburg, Freiburg, Germany
*CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
191
Tuesday Papers/
Minisymposium
8:30 am – 10:15 am
2613 — 8:45 GTF2IRD1 is a DualFunctionTranscription Factor that Promotes
M Opsin Gene Expression and Suppresses S
Opsin Gene Expression in M Cones. Donald J.
Zack1, A. Yerrabelli1, X. Zhang2, E. A. Conner3,
S. S. Thorgeirsson3, A. Swaroop4, S. Chen2, T.
Masuda1. 1Ophthalmology, Wilmer Eye Inst, Johns
Hopkins Univ, Baltimore, MD; 2Ophthalmology
and Visual Sciences, Washington University School
of Medicine, St. Louis, MO; 3National Cancer
Institute, Bethesda, MD; 4National Eye Institute,
Bethesda, MD *CR
2618 — 10:00 Role of 5-hydroxymethylcytosine
during postnatal retinal development. Stylianos
Michalakis1, A. Perera1, S. Koch1, M. Wagner2, L.
Windhager3, K. Nagel-Wolfrum4, T. M. Strom5, 6, R.
Zimmer3, T. Carell2, M. Biel1. 1Center for Integrated
Protein Science at the Department of PharmacyCenter for Drug Research, Ludwig-MaximiliansUniversität München, Munich, Germany; 2Center
for Integrated Protein Science at the Department
of Chemistry, Ludwig-Maximilians-Universität
München, Munich, Germany; 3Institute for
Informatics, Ludwig-Maximilians-Universität
München, Munich, Germany; 4Department of
Cell and Matrix Biology, Institute of Zoology,
Johannes Gutenberg University-Mainz, Mainz,
Germany; 5Institute of Human Genetics, Technische
Universität München, Munich, Germany; 6Institute
of Human Genetics, Helmholtz Zentrum München,
German Research Center for Environmental Health,
Neuherberg, Germany
Tuesday Papers/
Minisymposium
8:30 am – 10:15 am
2626 – 2640 – Tuesday – Papers/Minisymposium
6C
6E
606/607
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Retina / Clinical/Epidemiologic Research
Glaucoma
Multidisciplinary Ophthalmic Imaging
303 Metabolomics and Lipidomics:
Metabolic Fingerprints Offer New
Insights into Disease Pathogenesis with
Potential for Life Changing Research Minisymposium
304 Perimetry I
305 Clinical Application of
Ocular Imaging
Metabolomics has emerged as an important science
in helping to understand the relationships between
disease and risk factors. It exploits advances in
mass spectroscopy to identify classes of small
molecules and examine their profiles against disease
states. There is excitement as recent studies indicate
that this field of science is helping to unravel the
pathogenesis of chronic and late onset diseases
such as Alzheimer’s. There is now an increasing
recognition that metabolomics could be extremely
valuable in providing a better understanding of the
important blinding disorders of age-related macular
degeneration, diabetic retinopathy and glaucoma.
Furthermore a sub field of metabolomics which uses
the profiles of small metabolites and lipids in serum
and plasma is now being exploited in a variety of
medical applications. The advent of hyphenated
mass spectrometry has yielded a wealth of new
information on the lipid profiles present in normal
and diseased states and is referred to as lipidomics.
Lipids have been traditionally regarded as small
molecular weight compounds that are difficult to
measure accurately. In many disease states only
easy to measure and abundant lipids have been
used as biomarkers for disease, e.g. cholesterol.
However lipidomics has galvanized further interest.
We propose this symposium in order to educate
the vision science community on this powerful
new science and its potential applications to
ophthalmology.
Moderators: Usha Chakravarthy, Jennifer J.
Kang Mieler and Astrid E. Fletcher
— 8:30 Introduction
2626 — 8:35 Metabolomics. Expanding Tools
for Investigation of Chronic Diseases. Christopher
Elliott. Institute for Global Food safety, Queen’s
University Belfast, Belfast, United Kingdom
2627 — 8:55 Methods of Metabolomic Analysis
and Handling Complex Datasets. Jeffrey M.
Macdonald. Biomedical Engineering, University of
North Carolina, Chapel Hill, NC
2628 — 9:15 The Role of Metabolomics
in Studying Complications of Diabetes and
Cardiovascular Diseases. Warwick Dunn.
University of Birmingham, Birmingham, United
Kingdom
2629 — 9:35 Metabolomics and Retinal
Diseases. Milam A. Brantley. Ophthalmology,
Vanderbilt University, Nashville, TN
— 9:55 Discussion
Moderators: John G. Flanagan and
Joel S. Schuman
2630 — 8:30 Visual fields in patients with
glaucoma: variability, outliers, and the power
to detect change. Paul H. Artes1, 2, N. O’Leary1,
B. C. Chauhan1, 2, M. T. Nicolela1, 2, L. Shuba1, 2, P.
E. Rafuse1, 2. 1Ophthalmology and Visual Sciences,
Dalhousie University, Halifax, NS, Canada; 2Nova
Scotia Eye Care Centre, Capital Health, Halifax,
NS, Canada *CR
2631 — 8:45 Enhancement of a Risk Calculator
to Assess Rates of Visual Field Progression in
Treated Glaucoma Patients using Topographic
Analysis. Rafael L. Furlanetto1, 2, C. De Moraes1,
A. Slobodnick3, J. M. Liebmann1, 3, R. Ritch1, 4.
1
Einhorn Clinical Research Center, New York Eye
and Ear Infirmary, New York, NY; 2Department
of Ophthalmology, Federal University of Sao
Paulo, Sao Paulo, Brazil; 3New York University
School of Medicine, New York, NY; 4Department
of Ophthalmology, New York Medical College,
Valhalla, NY *CR
2632 — 9:00 Key predictors of visual field test
reliability. Jason Ho1, S. Ameen1, L. Crawley1, E.
M. Normando1, 2, M. Cordeiro1, 2, P. A. Bloom1, 3, F.
Ahmed1. 1Glaucoma Research Unit, Western Eye
Hospital, London, United Kingdom; 2Glaucoma
& Retinal Degeneration Research Group, UCL
Institute of Ophthalmology, London, United
Kingdom; 3Ophthalmology Unit, The Hillingdon
Hospital, London, United Kingdom *CR
2633 — 9:15 A New Index to Monitor Central
Field Progression in Glaucoma. Gustavo De
Moraes1, 2, R. L. Furlanetto1, 2, J. M. Liebmann1, 2, R.
Ritch1, 2. 1Ophthalmology, New York Eye and Ear
Infirmary, New York, NY; 2Ophthalmology, New
York University Medical Center, New York, NY
*CR
2634 — 9:30 Determinants of Visual Field
Reliability. Pradeep Y. Ramulu, M. V. Boland,
J. Wang, L. Xu, J. Brown, D. S. Friedman.
Ophthalmology, Wilmer Eye Inst/Johns Hopkins,
Baltimore, MD *CR
2635 — 9:45 Rates of Glaucomatous Visual
Field Change in a Large Clinical Population.
Balwantray C. Chauhan, P. E. Rafuse, L. Shuba,
M. T. Nicolela, P. H. Artes. Ophthalmology &
Visual Sciences, Dalhousie University, Halifax, NS,
Canada *CR
Moderators: Gadi Wollstein and
James G. Fujimoto
2637 — 8:30 Three-dimensional Evaluation
of Retinal Ganglion Cell Axon Regeneration,
Pathfinding and Glial Reaction in Unsectioned
Tissue. Xueting Luo, Y. Salgueiro, S. R. Beckerman,
V. P. Lemmon, P. Tsoulfas, K. K. Park. University of
MIami, Miami, FL
2638 — 8:45 Repeatability of ThreeDimensional (3D) Microstructural Parameters
of the Lamina Cribrosa (LC) in Adaptive
Optics Spectral-Domain Optical Coherence
Tomography (AO-SDOCT). Zach Nadler1, B.
Wang1, 2, G. Wollstein1, D. X. Hammer3, R. D.
Ferguson4, H. Ishikawa1, 2, R. A. Bilonick1, 5, J. E.
Nevins1, L. Kagemann1, 2, J. S. Schuman1, 2. 1UPMC
Eye Center, Eye and Ear Institute, Ophthalmology
and Visual Science Research Center, Department
of Ophthalmology, University of Pittsburgh School
of Medicine, Pittsburgh, PA; 2Department of
Bioengineering, Swanson School of Engineering,
University of Pittsburgh, Pittsburgh, PA; 3Center
for Devices and Radiological Health, Food and
Drug Administration, Silver Spring, MD; 4Physical
Sciences Inc., Andover, MA; 5Department of
Biostatistics, Graduate School of Public Health,
University of Pittsburgh, Boston, MA *CR
2639 — 9:00 Intrinsic Optical Signal Mapping
of Localized Retinal Dysfunction. Xincheng
Yao, Q. Zhang, R. Lu. Department of Biomedical
Engineering, University of Alabama at Birmingham,
Birmingham, AL *CR
2640 — 9:15 Characteristics of Optic Nerve
Development Using Hand-Held Ultra-High
Resolution Spectral Domain Optical Coherence
Tomography in Premature and Full-term
Neonates. Aarti Patel1, 2, H. Lee1, 2, V. Sheth1, 2, G.
Maconachie1, 2, F. A. Proudlock1, R. J. McLean1,
S. Anwar2, J. Fawke3, I. Gottlob1. 1Ophthalmology
Group, University of Leicester, Leicester, United
Kingdom; 2Department of Ophthalmology,
University Hospitals of Leicester, Leicester, United
Kingdom; 3Department of Neonataology, University
Hospitals of Leicester, Leicester, United Kingdom
2636 — 10:00 The Effect of Stimulus Size on
the Relation between Sensitivity and Variability
in Perimetry. Stuart K. Gardiner1, D. Goren1,
C. Goldman1, W. H. Swanson2, S. Demirel1.
1
Discoveries In Sight Laboratories, Devers Eye
Institute, Portland, OR; 2School of Optometry,
Indiana University, Bloomington, IN *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
192
Tuesday – Papers/Minisymposium – 2641 – 2654
2641 — 9:30 Visualization and Automatic
Diameter Evaluation of In Vivo Choroidal
Vessels by High-Penetration Optical Coherence
Tomography. Yoshiaki Yasuno1, 4, Y. Hong1, 4, M.
Ju2, 4, M. Miura3, 4, L. Duan1, 4. 1Computational
Optics Group, University of Tsukuba, Tsukuba,
Japan; 2Department of Electrical and Computer
Engineering, University of British Columbia,
Vancouver, BC, Canada; 3Department of
Ophthalmology, Ibaraki Medical Center, Tokyo
Medical University, Ami, Japan; 4Computational
Optics and Ophthalmology Group, Tsukuba, Japan
*CR
2642 — 9:45 Extended-imaging-depth (16mm)
Spectral Domain OCT Operating at 1310-nm
for Anterior Segment Biometry of the Human
Eye. Gongpu Lan1, P. Li1, L. an1, D. S. Malchow3,
M. A. Johnstone2, R. K. Wang1, 2. 1Bioengineering,
University of Washington, Seattle, WA;
2
Ophthalmology, University of Washington, Seattle,
WA; 3Sensors Unlimited Inc (SUI), Princeton, NJ
*CR
611-614
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Retinal Cell Biology
306 Protein Trafficking in
Photoreceptors and Interactions
Between the Retina and RPE
2647 — 9:15 MERTK regulation of the Rab
GTPase effector GDI1 from the superfamily
of GDI/CHM proteins. Shameka Shelby1, K. L.
Feathers1, L. Jia1, F. Mei1, D. A. Thompson1, 2.
1
Ophthalmology & Visual Sciences, University of
Michigan, Ann Arbor, MI; 2Biological Chemistry,
University of Michigan, Ann Arbor, MI
2648 — 9:30 Modulation of the Daily Rhythm
in Disc Shedding by Melatonin in the Mouse.
Gianluca Tosini1, V. Laurent2, K. Baba1, S.
Hiragaki1, S. Contreras-Alcantara1, D. Hicks2.
1
Pharmacology, Morehouse School of Medicine,
Atlanta, GA; 2Institut des Neurosciences Cellulaires
et Intégratives, CNRS UPR 3212 Université de
Strasbourg, Strasbourg, France
2649 — 9:45 Metabolic Coupling Between the
Retinal Pigment Epithelium (RPE) and Retina.
Jeffrey Adijanto1, E. L. Seifert1, C. Moffat1, A.
Maminishkis2, N. J. Philp1. 1Pathology, Anatomy
& Cell Biology, Thomas Jefferson University,
Philadelphia, PA; 2National Eye Institute, National
Institutes of Health, Bethesda, MD
2650 — 10:00 Global identification of RPE
phagocytosis ligands by phagoligandomics. Wei
Li1, N. B. Caberoy2, G. S. Alvarado1, H. Wang3, F.
Wang3, R. Chen3. 1Ophthalmology, Univ of Miami
Miller Sch of Med, Miami, FL; 2Life Science,
University of Nevada at Las Vegas, Las Vegas, NV;
3
Molecular & Human Genetics, Baylor College of
Medicine, Houston, TX
Moderators: Nancy J. Philp and
Vadim Y. Arshavsky
615-617
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Clinical/Epidemiologic Research
307 Glaucoma Epidemiology: Teasing
Out Mechanisms and Understanding
the Burden
Moderators: Linda M. Zangwill and
Anthony P. Khawaja
2651 — 8:30 Clarifying the role of ATOH7
in glaucoma endophenotypes. Ananth C.
Viswanathan1, 2, C. Venturini3, 4, P. G. Hysi4, A. Nag4,
E. Yonova4, J. Wang7, 8, T. Y. Wong5, 6, P. R. Healey9,
P. Mitchell9, 8, C. J. Hammond4. 1Glaucoma Service,
Moorfields Eye Hospital, London, United Kingdom;
2
NIHR Biomedical Research Centre, Moorfields
Eye Hospital and UCL Institute of Ophthalmology,
London, United Kingdom; 3Genetics, UCL Institute
of Ophthalmology, London, United Kingdom;
4
Twin Research and Genetic Epidemiology, King’s
College London St. Thomas’ Hospital, London,
United Kingdom; 5Epidemiology and Public Health,
National University of Singapore, Singapore,
Singapore; 6Singapore Eye Research Institute,
Singapore, Singapore; 7Centre for Eye Research
Australia (CERA) Department of Ophthalmology,
University of Melbourne, Melbourne, NSW,
Australia; 8Department of Ophthalmology,
University of Sydney Centre for Vision Research,
Sydney, NSW, Australia; 9Department of
Ophthalmology, University of Sydney, Sydney,
NSW, Australia *CR
2652 — 8:45 Pseudoexfoliation: Normative
Data and Associations. The Beijing Eye Study
2011. Qisheng You1, Y. Wang1, L. Xu1, J. B.
Jonas2, 1. 1Beijing Institute of Ophthalmology,
Beijing Tongren Hospital, Capital University of
Medical Science, Beijing, China; 2Department of
Ophthalmology, Universitätsmedizin Mannheim,
Medical Faculty Mannheim, Heidelberg University,
Mannheim, Germany *CR
2653 — 9:00 The association of
pseudoexfoliation syndrome (PEX) with
cardiovascular (CVD) and cerebrovascular
(CVA) disease: a systematic review and metaanalysis. Helen Chung, S. Arora, K. F. Damji, E.
Weis. University of Alberta, Edmonton, AB, Canada
2644 — 8:30 Outer Segment Targeting
of R9AP in Mouse Rod Photoreceptors.
Jillian N. Pearring1, S. Gospe2, S. A. Baker3,
V. Y. Arshavsky1, 2. 1Duke Eye Center, AERI,
Duke University, Durham, NC; 2Department
of Pharmacology and Cancer Biology, Duke
Univsersity, Durham, NC; 3Department of
Biochemistry, University of Iowa, Iowa City, IA
2654 — 9:15 Corneal hysteresis and glaucomarelated quantitative traits in the EPIC-Norfolk
Eye Study. Anthony P. Khawaja1, M. P. Chan2,
D. C. Broadway3, D. F. Garway-Heath4, R.
Luben1, K. Khaw1, P. J. Foster2, 4. 1Department
of Public Health and Primary Care, University
of Cambridge, Cambridge, United Kingdom;
2
Division of Genetics and Epidemiology, UCL
Institute of Ophthalmology, London, United
Kingdom; 3Department of Ophthalmology, Norfolk
& Norwich University Hospital, Norwich, United
Kingdom; 4NIHR Biomedical Research Centre,
Moorfields Eye Hospital NHS Foundation Trust and
UCL Institute of Ophthalmology, London, United
Kingdom *CR
2645 — 8:45 The Drosophila SNARE Protein,
Gos28, is Critical for Rhodopsin Transport and
Photoreceptor Viability. Nansi J. Colley1, 2, E. E.
Rosenbaum1, 2, K. Brehm1, 2, E. Vasiljevic1, 2. 1Ophth
& Vis Sci & Genetics, Univ of Wisconsin-Madison,
Madison, WI; 2McPherson Eye Research Institute,
University of Wisconsin, Madison, WI
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
193
Tuesday Papers/
Minisymposium
8:30 am – 10:15 am
2643 — 10:00 In-vivo Confocal and twophoton fluorescence microscopy on the cornea
of diabetic and non-diabetic thy1 YFP mice.
Alexander Heisterkamp1, T. Ehmke1, M. Reichard3,
H. Weiss2, S. Baltrusch2, O. Stachs3. 1Institute of
Applied Optics, Friedrich-Schiller-University Jena,
Jena, Germany; 2University of Rostock, Department
of Medical Biochemistry and Molecular Biology,
Rostock, Germany; 3University of Rostock,
Department of Ophthalmology, Rostock, Germany
2646 — 9:00 Investigation of protease
candidates for the release of soluble MerTK
during photoreceptor outer segments
phagocytosis by retinal pigment epithelial
cells. Celia Parinot, J. Chatagnon, E. F. Nandrot.
Therapeutics, INSERM, U968, UPMC Univ Paris
06, UMR_S 968, Institut de la Vision, CNRS,
UMR_7210, Paris, France *CR
2655 – 2671 – Tuesday – Papers/Minisymposium
Tuesday Papers/
Minisymposium
8:30 am – 10:15 am
2655 — 9:30 Glaucomatous progression in the
African Descent and Glaucoma Evaluation Study
(ADAGES). Linda M. Zangwill1, N. Khachatryan1,
S. Jain2, F. He2, F. A. Medeiros1, C. Bowd1, R.
Lisboa1, R. N. Weinreb1, J. M. Liebmann3, 4, C. A.
Girkin5. 1Ophthalmology, Hamilton Glaucoma
Center, University of California, San Diego, La
Jolla, CA; 2Departmen of Family and Preventive
Medicine, University of Cailfornia, San Diego, La
Jolla, CA; 3New York University, New York, NY;
4
Ophthalmology, Einhorn Clinical Research Center,
New York Eye and Ear Infirmary, New York, NY;
5
School of Medicine, University of AlabamaBirminghm, Birmingham, AL *CR, f
2656 — 9:45 Number of People with Glaucoma
in Asia in 2020 and 2040: A Hierarchical
Bayesian Meta-Analysis. Xiang LI1, 4, E. W. Chan2,
J. Liao2, T. Y. Wong2, 4, T. Aung2, 4, C. Cheng2, 3.
1
Department of Statistics and Applied Probability,
National University of Singapore, Singapore,
Singapore; 2Department of Ophthalmology,
National University Health system, Singapore,
Singapore; 3Department of Ophthalmology, Yong
Loo Lin School of Medicine, National University of
Singapore, Singapore, Singapore; 4Singapore Eye
Research Institute, National Eye Centre, Singapore,
Singapore *CR
2657 — 10:00 The Cost of Glaucoma Care
Provided to a Sample of Medicare Beneficiaries
from 2002-2009. Harry Quigley1, S. D. Cassard1,
E. W. Gower2, P. Y. Ramulu1, H. D. Jampel1, D. S.
Friedman1. 1Ophthalmology, Johns Hopkins Wilmer
Eye Inst, Baltimore, MD; 2Ophthalmology, Wake
Forest, Winston-Salem, NC *CR
TCC LL 4/5
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Visual Psychophysics / Physiological Optics
308 Binocular Vision and Stereopsis
Moderators: Robert F. Hess and Peter Bex
2658 — 8:30 Mechanisms underlying global
stereopsis in fovea and periphery. Robert F.
Hess, N. Witz. Ophthalmology, McGill University,
Montreal, QC, Canada
2659 — 8:45 Effect of inter-ocular differences
in blur on spatial and stereo-resolution. Sowmya
Ravikumar1, B. Vlaskamp2, M. S. Banks1. 1Vision
Science, University of California Berkeley,
Berkeley, CA; 2Philips Research, Eindhoven,
Netherlands *CR
2660 — 9:00 Binocular combination of
optically-induced asymmetric interocular blur.
Aixa Alarcon1, L. Zheleznyak2, 1, M. S. Banks3,
G. Yoon1, 2. 1Flaum Eye Institute, University of
Rochester, Rochester, NY; 2Institute of Optics,
University of Rochester, Rochester, NY; 3Vision
Science Program, University of California Berkeley,
Berkeley, CA *CR
2661 — 9:15 The Effect of Unilateral Mean
Luminance on Binocular Combination in normal
and amblyopic vision. Chang-Bing Huang1, J.
Zhou2, R. F. Hess2. 1Key Laboratory of Behavioral
Science, Institute of Psychology, Chinese Academy
of Sciences, Beijing, China; 2Department of
Ophthalmology, McGill Vision Research, McGill
University, Montreal, QC, Canada
2662 — 9:30 The Contribution of Perspective,
Blur and Disparity to Depth Perception in
Natural Vision. Guido Maiello1, 2, M. Chessa2, F.
Solari2, P. Bex1. 1Department of Ophthalmology,
Harvard Medical School, Boston, MA; 2Department
of Informatics, Bioengineering, Robotics and
System Engineering, University of Genoa, Genoa,
Italy *CR
2663 — 9:45 Rapid assessment of core visual
deficits in amblyopia. MiYoung Kwon1, L. A.
Lesmes1, A. Miller1, M. Kazlas2, M. Dorr1, D. G.
Hunter2, 1, Z. Lu3, P. Bex1. 1Ophthalmology, Harvard
Medical School, Boston, MA; 2Ophthalmology,
Boston Children’s Hospital, Boston, MA;
3
Psychology, Ohio State University, Columbus, OH
*CR
2664 — 10:00 Binocular Visual Acuity
with Combined Correction of Spherical and
Longitudinal Chromatic Aberrations. Christina
Schwarz, S. Manzanera, P. M. Prieto, P. Artal.
Laboratorio de Optica, Universidad de Murcia,
Murcia, Spain *CR
TCC 303
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Cornea
309 Dry Eye and Lacrimal Gland III
Moderators: David A. Sullivan and Pablo Argueso
2665 — 8:30 Prevalence and Determinants
of Dry Eye Disease in a British Female
Cohort. Jelle Vehof2, 1, D. Kozareva2, P. G.
Hysi2, S. J. Fahy2, 4, K. Direk2, T. Spector2, C. J.
Hammond2, 3. 1Ophthalmology, University Medical
Center Groningen, Groningen, Netherlands;
2
Twin Research & Genetic Epidemiology, St
Thomas’Hospital, King’s College London,
London, United Kingdom; 3Ophthalmology, St
Thomas’Hospital, King’s College London, London,
United Kingdom; 4Division of Primary Care,
University of Nottingham, Nottingham, United
Kingdom
2666 — 8:45 Role of galectin-3 in dry eye
disease. Yuichi Uchino1, J. Mauris1, J. Dieckow1,
A. M. Woodward1, F. Amparo1, R. Dana1, F.
Mantelli2, P. Argueso1. 1Schepens Eye Research
Institute and Massachusetts Eye and Ear, Dept. of
Ophthalmology, Harvard Medical School, Boston,
MA; 2Ophthalmology, Campus Bio-Medico,
University of Rome, Rome, Italy *CR
2667 — 9:00 Topical administration of
lacritin promotes tear secretion and improves
ocular surface integrity in a mouse model of
autoimmune dry eye. Thirugnana Vijmasi1,
F. Chen1, R. L. McKown2, G. W. Laurie3, N. A.
McNamara1. 1Francis I Proctor Foundation,
University of California San Francisco, San
Francisco, CA; 2Department of Integrated Science
and Technology, James Madison University,
Harrisonburg, VA; 3Department of Cell Biology,
University of Virginia, Charlottesville, VA *CR
2668 — 9:15 Bridging ocular therapeutics and
contact lenses via thermo-responsive protein
polymers. Wan Wang1, P. Shi1, S. Aluri1, P. Hsueh1,
M. C. Edman1, D. S. Ryan6, R. L. McKown5, S. F.
Hamm-Alvarez1, 3, G. W. Laurie4, J. A. MacKay1, 2.
1
Department of Pharmacology and Pharmaceutical
Sciences, University of Southern California,
Los Angeles, CA; 2Department of Biomedical
Engineering, University of Southern California,
Los Angeles, CA; 3Keck School of Medicine,
University of Southern California, Los Angeles,
CA; 4University of Virginia, Charlottesville, VA;
5
Department of Integrated Science and Technology,
James Madison University, Harrisonburg, VA; 6US
Army Warfighter Refractive Surg Research Ctr, Fort
Belvoir, VA *CR
2669 — 9:30 Lifitegrast 5.0% Ophthalmic
Solution Reduces Ocular Surface Staining and
Improves Symptoms in Patients with Dry Eye
Disease: Results of a Phase 3 Study (OPUS-1).
Charles P. Semba1, G. L. Torkildsen2, F. A.
D’Ambrosio3, J. Lonsdale4, E. B. McLaurin5, R. A.
Eiferman6, K. S. Kennedy7, J. D. Sheppard8. 1Dept.
Ophthalmology and Visual Sciences, SARcode
Bioscience, Inc., Brisbane, CA; 2Andover Eye
Associates, Andover, MA; 3D’Ambrosio Eye Care,
Lancaster, MA; 4Central Maine Eye Care, Lewiston,
ME; 5Total Eye Care, Memphis, TN; 6University
of Louisville, Louisville, KY; 7Independent
Biostatistical Consultants, Tempe, AZ; 8Eastern
Virginia Medical School, Norfolk, VA *CR, f
2670 — 9:45 Effects of L-carnitine, Erythritol
and Betaine on Inflammatory Markers in
Primary Human Corneal Epithelial Cells
Exposed to Hyperosmotic Stress. Xia Hua1, 2, Z.
Su1, 3, R. Deng1, 3, J. Lin1, D. Li1, S. C. Pflugfelder1.
1
Ophthalmology, Baylor College of Medicine,
Houston, TX; 2Ophthalmology, Tianjin Eye
Hospital, Tianjin, China; 3Ophthalmology, School
of Optometry and Ophthalmology, Wenzhou, China
*CR
2671 — 10:00 Age-related changes
in the meibomian gland revealed by
Immunofluorescent Computed Tomography.
Geraint J. Parfitt, Y. Xie, D. J. Brown, J. V.
Jester. Gavin Herbert Eye Institute, University of
California, Irvine, Irvine, CA
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
194
Tuesday – Papers/Minisymposium – 2672 – 2678
TCC 304
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Visual Neuroscience
310 Visual Behavior, Disease,
and Restoration
Moderators: Alexander Sher and
Maureen A. McCall
2672 — 8:30 Exogenous zinc ions interrupt
visual signal transmission from photoreceptors
to bipolar cells and reduce retinal TRPM1
expression in mouse. Bo Lei, Y. Liu, T. Lin,
H. Yang. Department of Ophthalmology, The
First Affiliated Hospital of Chongqing Medical
University, Chongqing Key Laboratory of
Ophthalmology, Chongqing Eye Institute,
Chongqing, China
2677 — 9:45 Constructive Retinal Plasticity
After Selective Ablation of the Photoreceptors.
Corinne N. Beier1, B. W. Jones3, P. Huie4, 5, Y. M.
Paulus4, 5, D. Lavinsky4, 5, L. B. Leung4, H. Nomoto4,
R. E. Marc3, D. V. Palanker4, 5, A. Sher2. 1Electrical
Engineering, University of California - Santa Cruz,
Santa Cruz, CA; 2Santa Cruz Institute for Particle
Physics, University of California - Santa Cruz,
Santa Cruz, CA; 3Moran Eye Institute, University of
Utah, Salt Lake City, UT; 4Ophthalmology, Stanford
University, Stanford, CA; 5Hansen Experimental
Physics Laboratory, Stanford University, Stanford,
CA *CR
2678 — 10:00 Optogenetic Targeting of ON
and OFF bipolar cells for vision restoration.
Jun-Kyo F. Suh1, J. Kim1, H. Moon1, H. Shin1, E.
Hwang1, D. Kang2, C. J. Lee2. 1Center for Bionics
Research, Korea Inst of Science and Technology,
Seoul, Republic of Korea; 2Center for Functional
Connectomics, Korea Institute of Science and
Technology, Seoul, Republic of Korea *CR
Tuesday Papers/
Minisymposium
8:30 am – 10:15 am
2673 — 8:45 Molecular coupling between
TRPV4 and aquaporin 4 channels mediates
osmosensation in Müller glia. David Krizaj1, 2, D.
A. Ryskamp1, A. O. Jo1, A. Verkman3, N. Macaulay4.
1
Ophthalmology & Visual Sciences, Univ of Utah
School of Med, Salt Lake City, UT; 2Physiology,
University of Utah School of Med, Salt Lake
City, UT; 3Medicine, University of California
San Francisco, San Francisco, CA; 4Cellular and
Molecular Medicine, University of Copenhagen,
Copenhagen, Denmark
2674 — 9:00 Nonlinear Pupil Responses
to Rod and Cone Inputs. Dingcai Cao1, P. A.
Barrionuevo1, N. Nicandro1, J. McAnany1, A. J.
Zele2, P. D. Gamlin3. 1Ophthalmology and Visual
Sciences, University of Illinois at Chicago, Chicago,
IL; 2Optometry and Vision Sciences, Queensland
University of Technology, Brisbane, QLD,
Australia; 3Vision Sciences, University of Alabama
at Birmingham, Birmingham, AL
2675 — 9:15 Diabetic retinopathy alters retinal
ganglion cell function and light responsiveness
in the Ins2Akita mouse model of diabetes. Rene
C. Renteria, N. P. Akimov, S. Lu. Department of
Physiology, University of Texas Health Science
Center at San Antonio, San Antonio, TX
2676 — 9:30 Effects of Nrl knockout on visual
signal in mouse retina. Yichao Li1, J. E. Roger2,
R. A. Rachel2, A. Swaroop2, H. Qian1. 1Visual
Function Core, National Eye Institute, Bethesda,
MD; 2Neurobiology Neurodegeneration & Repair
Laboratory, National Eye Institute, Bethesda, MD
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
195
2679 – 2700 – Tuesday – Posters
Exhibit Hall A0001-A0028
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Retinal Cell Biology
311 Diabetic Retinopathy and
Vascular Biology I
Moderators: Nader Sheibani and
Bruce A. Berkowitz
Tuesday Posters
8:30 am – 10:15 am
2679 — A0001 Lack of CX3CR1 Prevents
Retinal Vascular Rarefaction Associated with ER
Stress, Neuronal Degeneration, and Diabetes.
Shoujian Wang, C. M. Sorenson, N. Sheibani.
Department of Ophthalmology and Visual Sciences,
University of Wisconsin-Madison, Madison, WI
2680 — A0002 Impaired Chromophore
Availability in the Diabetic Retina: Impact on
Visual Performance. Bruce A. Berkowitz1, T. S.
Kern2, 3, V. J. Kefalov4, J. Von Lintig2, R. Roberts1,
D. Bissig1. 1Anatomy/Cell Biol & Ophthal, Wayne
State Univ Sch of Med, Detroit, MI; 2Pharmacology,
Case Western Reserve University, Cleveland,
OH; 3Stokes VA Medical Center, Cleveland, OH;
4
Ophthalmology, Washington University in St.
Louis, St. Louis, MO *CR
2681 — A0003 Hyperglycemia in the
newborn rat induces retinal vascular
growth retardation and the recruitment of
inflammatory macrophages to the retina. Xavier
P. Guillonneau1, 2, E. Kermorvant3, 4, D. Lenne1, 2,
S. Lavalette1, 2, W. Raoul1, 2, B. Calippe1, 2, F.
Sennlaub1, 2. 1U968 Institut de la Vision, Institut
National de la Santé et de la Recherche Médicale,
Paris, France; 2UMR_S 968, Université Pierre et
Marie Curie, Paris, France; 3U872, Institut National
de la Santé et de la Recherche Médicale, Paris,
France; 4Service de Réanimation Pédiatrique et
Néonatale, Hôpital Necker-Enfants Malades, Paris,
France
2682 — A0004 Shedding of Vascular Adhesion
Protein-1 by VEGF Stimulation under High
Glucose Condition. Shiho Namba1, 2, K. Noda1, 2, M.
Murata1, 2, A. Kanda1, 2, S. Ishida1, 2. 1Laboratory of
Ocular Cell Biology and Visual Science, Hokkaido
University Graduate School of Medicine, Sapporo,
Japan; 2Department of Ophthalmology, Hokkaido
University Graduate School of Medicine, Sapporo,
Japan
2683 — A0005 The effect of preterm birth
on normal retinal vascular development and
oxygen-induced retinopathy in neonatal rat.
Yusheng Wang, R. Li. Xijing Hospital, Fourth
Military Medical University, Xi’an, China
2684 — A0006 Specific Role and Regulation of
αA- and αB-Crystallins in Diabetic Retinopathy.
Patrice E. Fort, S. A. Grafton, K. M. Roth.
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI *CR
2685 — A0007 Inhibition of Calcineurin/
NFAT signaling in retinal endothelial cells
reduces VEGF-induced inflammatory response.
Sara R. Savage1, C. A. Bretz2, J. S. Penn1, 3.
1
Pharmacology, Vanderbilt University School of
Medicine, Nashville, TN; 2Cell and Developmental
Biology, Vanderbilt University School of Medicine,
Nashville, TN; 3Ophthalmology and Visual
Sciences, Vanderbilt University School of Medicine,
Nashville, TN *CR
2686 — A0008 Expression of Inflammatory
Mediators in Eyes of Spontaneously Type-2
Diabetic Monkeys. Imran A. Bhutto1, J. R. Yates1,
M. A. Johnson2, C. Merges1, B. C. Hansen3, G.
A. Lutty1. 1Ophthalmology, Johns Hopkins Hosp
Wilmer Eye Inst, Baltimore, MD; 2Ophthalmology,
University of Maryland School of Medicine,
Baltimore, MD; 3Internal Medicine and Pediatrics,
University of South Florida, Tampa, FL *CR
2687 — A0009 High Glucose-Induced Connexin
43 (Cx43) Downregulation Modulates Rho/
Rho kinase (ROCK) Signaling and Promotes
Apoptosis in Retinal Endothelial Cells. Tetsuya
Muto, S. Roy. Medicine and Ophthalmology, Boston
University School of Medicine, Boston, MA
2688 — A0010 Reduced Connexin 43 (Cx43)
plays a role in the development of vascular
lesions in human diabetic retinopathy. Thomas
Tien1, T. Muto1, E. H. Sohn2, R. F. Mullins2, S. Roy1.
1
Ophthalmology and Medicine, Boston University
School of Medicine, Boston, MA; 2Ophthalmology
and Visual Science, The University of Iowa, Iowa
City, IA *CR
2689 — A0011 Connexin 43 (Cx43)
Upregulation Protects Retinal Endothelial Cells
Against High Glucose Insult. Kevin F. Barrette, L.
Challyandra, S. Roy. Boston University School of
Medicine, Boston, MA
2690 — A0012 Purinergic vasotoxicity
in retinal capillaries. Maho Shibata, A.
Nakaizumi, T. Zhang, E. Ishizaki, M. Fukumoto,
A. Barajas-Espinosa, D. G. Puro. Department of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI
2691 — A0013 Accelerated retinal
microvasculopathy in BMAL1 deficient mice.
Ashay D. Bhatwadekar1, Y. Diao2, J. Al-Sabah1,
S. Caballero1, C. Lee3, M. S. Segal2, M. B. Grant1.
1
Pharmacology & Therapeutics, University
of Florida, Gainesville, FL; 21BDivision of
Nephrology, Hypertension & Renal Transplantation,
University of Florida, Gainesville, FL; 3Department
of Biomedical Sciences, Florida State University,
Tallahassee, FL
2692 — A0014 Upregulation of activator
protein 1 (c-Fos/c-Jun) and c-Jun N-terminal
kinase associated with neuronal cell death in
retinas of diabetic patients. Toshiyuki Oshitari1,
S. Yamamoto1, S. Roy2. 1Ophthalmology, Chiba
Univ Grad Sch of Med, Chiba, Japan; 2Medicine
and Ophthalmology, Boston Univesity School of
Medicine, Boston, MA
2693 — A0015 Heparanase Regulates
Transcription Activity of VEGF Gene in Human
Retinal Microvascular Endothelial Cells induced
by hyperglucose. Jie Hu. Zhongshan Ophthalmic
Center, Guangzhou, China
2694 — A0016 Telmisartan increases the
levels of brain derived neurotrophic factor
and glutathione in the retina of streptozotocininduced diabetic rats. Mohammad S. Ola1, M. I.
Nawaz2, H. M. Abuohashish3, A. S. Alhomaida1,
S. S. Al-Rejai3, M. M. Ahmed3. 1Biochemistry,
College of Science, King Saud University, Riyadh,
Saudi Arabia; 2Ophthalmology, King Saud
University, Riyadh, Saudi Arabia; 3Pharmacology
& Toxicology, King Saud University, Riyadh, Saudi
Arabia
2695 — A0017 Effect of Experimental Diabetic
Retinopathy on the Non-Image Forming
Visual System. Pablo H. Sande, N. de Zavalia,
N. A. Belforte, D. Dorfman, R. E. Rosenstein,
D. C. Fernandez. Human Biochemistry/Sch of
Med, University of Buenos Aires, Buenos Aires,
Argentina
2696 — A0018 Vasoinhibins reduce the increase
of retinal vasopermeability associated with
diabetes: contribution of the kallikrein-kinin
system. David Arredondo1, O. Baldivieso Hurtado2,
D. Ochoa-Contreras2, C. Clapp1, S. Thebault1.
1
Instituto de Neurobiología UNAM, Querétaro,
Mexico; 2Hospital “Dr. Luis Sanchez Bulnes”,
Asociación Para Evitar la Ceguera en México,
I.A.P., Mexico city, Mexico
2697 — A0019 The imbalance of Th17 and Treg
cells in the retinopathy of diabetic rat model.
Chang He, Y. Sun, X. Hu, J. Wang, L. Wang, Y. Liu,
X. Liu. Zhongshan Ophthalmic Center, Sun yat-sen
University, Guangzhou, China
2698 — A0020 NFAT signaling induces
upregulation of cytokines that promote the
pathology of diabetic retinopathy. Colin A. Bretz,
J. S. Penn. Vanderbilt Eye Institute, Vanderbilt Univ
Med Center, Nashville, TN *CR
2699 — A0021 Role of proNGF/p75NTR
mediated RhoA activation in diabetes-induced
BRB breakdown. Barbara A. Mysona1, 2, S.
Matragoon1, A. B. El-Remessy1, 2. 1UGA Clinical
and Experimental Therapeutics, University of
Georgia, Augusta, GA; 2Vision Discovery Institute,
Georgia Health Sciences University, Augusta, GA
2700 — A0022 Dicer 1 loss and increased Alu
RNA in the pathogenesis of diabetic retinopathy.
Yuanqing Yan1, 2, T. Salazar1, 2, J. M. Dominguez2,
D. V. Nguyen2, S. Li Calzi2, A. D. Bhatwadekar2, J.
V. Busik3, M. E. Boulton4, M. B. Grant1, 2. 1Genetics
Institute, University of Florida, Gainesville, FL;
2
Department of Pharmacology and Therapeutics,
University of Florida, Gainesville, FL; 3Department
of Physiology, Michigan State University, East
Lansing, MI; 4Department of Anatomy and Cell
Biology, University of Florida, Gainesville, FL
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
196
Tuesday – Posters – 2701 – 2715
2701 — A0023 Role of TXNIP in High fat
Diet-induced Inflammasome Activation in
Retinal Endothelial Cells. Islam N. Mohamed1 3,
M. A. Rojas2, 3, R. B. Caldwell2, 3, A. Ergul1, 4,
A. B. El-Remessy1, 3. 1Clinical & Experimental
Therapeutics, University of Georgia, Augusta, GA;
2
Vascular Biology Center, Georgia Health Sciences
University, Augusta, GA; 3Vision Discovery
Institute, Georgia Health Sciences University,
Augusta, GA; 4Department of Physiology, Georgia
Health Sciences University, Augusta, GA
2702 — A0024 Paracrine Effects of Adipose
Stromal Cell Conditioned Media on Retina:
A Cell-free Therapy for Retinal Diseases.
Gangaraju Rajashekhar1, 2, C. Abburi1, R.
Maturi4, 1, A. Harris1, T. S. Kern5, K. L. March3, 2.
1
Ophthalmology, Eugene & Marilyn Glick
Eye Institute, Indiana Univ., Indianapolis, IN;
2
Indiana Center for Vascular Biology & Medicine,
Indianapolis, IN; 3Medicine, IU School of Medicine,
Indianapolis, IN; 4Mid West Eye Institute,
Indianapolis, IN; 5Ophthalmology, Case Western
Reserve University, Cleveland, OH *CR
2704 — A0026 Neuronal Socs3 deficiency
promotes pathologic retinal angiogenesis. Ye Sun,
J. Joyal, A. Stahl, C. G. Hurst, Z. Cui, L. Evans, Z.
Fu, Z. Shao, J. Chen, L. E. Smith. Ophthalmology,
Harvard Medical School/Boston Children’s
Hospital, Boston, MA
2705 — A0027 VEGF165b reduces blood vessel
permeability in diabetic retinas. Nikita Ved1, 3, R.
Hulse1, 2, L. F. Donaldson2, J. W. Bainbridge3, D.
O. Bates1. 1Microvascular Research Laboratories,
University of Bristol, Bristol, United Kingdom;
2
School of Physiology and Pharmacology,
University of Bristol, Bristol, United Kingdom;
3
National Institute for Health Research Biomedical
Research Centre for Ophthalmology, Moorfields
Eye Hospital and University College London
Institute of Ophthalmology, London, United
Kingdom *CR
2706 — A0028 Role of the Receptor for
Advanced Glycation Endproducts (RAGE)
in retinal vasodegenerative pathology during
diabetes. Carmel M. McVicar1, M. S. Ward1, L.
Colhoun1, D. Conway1, H. Hammes2, A. W. Stitt1.
1
Centre for Vision and Vascular Science, Queen’s
University Belfast, Belfast, United Kingdom;
2
Department of Medicine and Clinical Chemistry,
University of Heidelberg, Heidelberg, Germany
*CR
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Physiology/Pharmacology
312 Gene Therapy
Moderators: Ashim K. Mitra and Naj Sharif
2707 — A0151 Corrective Gene Therapy
for RPGR-XLRP Rescues a Canine Model at
Mid-Stage Disease. William A. Beltran1, A. V.
Cideciyan2, A. S. Lewin3, S. Iwabe1, S. L. Boye4, W.
W. Hauswirth4, S. G. Jacobson2, G. D. Aguirre1.
1
Clinical Studies, School of Veterinary Medicine,
University of Pennsylvania, Philadelphia, PA;
2
Ophthalmology, Scheie Eye Institute, School of
Medicine, University of Pennsylvania, Philadelphia,
PA; 3Molecular Genetics & Microbiology,
University of Florida, Gainesville, FL;
4
Ophthalmology, University of Florida, Gainesville,
FL *CR
2708 — A0152 Recovery of Visual Function
Following Gene Therapy in a Large Animal
Model of CNGA3 ACHROMATOPSIA. Edward
Averbukh1, R. Ofri2, E. Gootwine3, R. Ezra-Elia2,
H. H. Honig3, A. Rosov3, E. Yamin1, A. Obolensky1,
W. W. Hauswirth4, E. Banin1. 1Ophthalmology,
Hadassah Hebrew University Medical Center,
Jerusalem, Israel; 2Koret School of Veterinary
Medicine, Hebrew University of Jerusalem,
Jerusalem, Israel; 3Department of Ruminant
Research, Agricultural Research Organization, the
Volcani Center, Bet Dagan, Israel; 4Department of
Ophthalmology, University of Florida, Gainesville,
FL *CR
2709 — A0153 Phase I Gene Therapy Trial
in Israeli Patients with Leber Congenital
Amaurosis Caused by a Founder RPE65
Mutation: Safety and Efficacy Update with
Up to Two Years of Follow-up. Eyal Banin1, A.
Obolensky1, Y. Hemo1, D. Marks-Ohana1, M. Sela1,
E. Yamin1, W. W. Hauswirth2, S. G. Jacobson3,
D. Sharon1. 1Ophthalmology, Hadassah-Hebrew
Univ Med Ctr, Jerusalem, Israel; 2Ophthalmology,
University of Florida at Gainsville, Gainsville, FL;
3
Scheie Eye Institute, University of Pennsylvania,
Philadelphia, PA *CR, f
2710 — A0154 AAV Mediated Gene Transfer
Restores Retinal and Visual Function in
Lebercilin-/- (LCA5) Mice. Daniel C. Chung,
J. Bennicelli, A. Wojno, N. A. Commins, R. W.
Bloom, D. J. Bennett, T. T. Duong, M. Sivalingam,
A. Lyubarsky, J. Bennett. FM Kirby Center for
Molecular Ophthalmology, Scheie Eye Institute,
University of Pennsylvania Perelman School of
Medicine, Philadelphia, PA *CR
2711 — A0155 AAV-Mediated Expression of
Secreted Human Ciliary Neurotropic Factor
(hCNTF) Leads to Long-Term Preservation of
Cone Photoreceptors in an Autosomal Recessive
Model of Retinitis Pigmentosa. Daniel M.
Lipinski1, A. R. Barnard1, M. S. Singh1, E. Lee2, R.
E. MacLaren1, 2. 1Nuffield Lab of Ophthalmology,
University of Oxford, Oxford, United Kingdom;
2
Moorfield Eye Hospital and University College
London Institute of Ophthalmology Biomedical
Research Centre, London, United Kingdom
2712 — A0156 Ultrahigh Resolution Mouse
Optical Coherence Tomography to Aid Retinal
Gene Therapy Research. Mark C. Butler1, 2, T. A.
Kolniak3, J. Sullivan1, 4. 1Research Service, Veterans
Administration Western NY Healthcare System,
Buffalo, NY; 2Ophthalmology, SUNY at Buffalo,
Buffalo, NY; 3Program in Neuroscience, SUNY
at Buffalo, Buffalo, NY; 4Ophthalmology, Pharm/
Tox, Phys/Biophys, SUNY Eye Institute, SUNY at
Buffalo, Buffalo, NY
2713 — A0157 Human MiniPromoters with
Restricted-Retinal Expression when Docked in
the Mouse Genome Show the Same Restricted
Expression when Delivered in Adeno-Associated
Virus (AAV). Elizabeth M. Simpson1, 2, C. N.
de Leeuw1, 2, F. M. Dyka3, S. L. Boye3, M. Zhou1,
L. Borretta1, R. Holt4, 5, D. Goldowitz1, 2, W. W.
Hauswirth3, W. Wasserman1, 2. 1Centre for Molecular
Medicine and Therapeutics at the Child and
Family Research Institute, University of British
Columbia, Vancouver, BC, Canada; 2Department
of Medical Genetics, University of British
Columbia, Vancouver, BC, Canada; 3Department of
Ophthalmology, College of Medicine, University of
Florida, Gainesville, FL; 4Canada’s Michael Smith
Genome Sciences Centre, British Columbia Cancer
Agency, Vancouver, BC, Canada; 5Department of
Molecular Biology and Biochemistry, Simon Fraser
University, Vancouver, BC, Canada *CR
2714 — A0158 Sustained Transgene Expression
with Non-viral Gene Transfer Following
Chitosan Mediated Delivery. Ana Vanessa
Oliveira1, 4, G. A. Silva2, 3, D. C. Chung4. 1Doctoral
Program in Biomedical Sciences, Department of
Biomedical Sciences and Medicine, University
of Algarve, Faro, Portugal; 2Centre for Molecular
and Structural Biomedicine (CBME/IBB, LA),
University of Algarve, Faro, Portugal; 3Department
of Biomedical Sciences and Medicine, University
of Algarve, Faro, Portugal; 4F.M. Kirby Center for
Molecular Ophthalmology, Scheie Eye Institute,
University of Pennsylvania Perelman School of
Medicine, Philadelphia, PA
2715 — A0159 AAV-mediated Lpcat1
gene replacement therapy rescues retinal
degeneration in rd11 mice. Xufeng Dai1, J. Han1,
Z. Jin1, Y. Qi1, J. Li2, W. Deng2, B. Chang3, W. W.
Hauswirth2, J. Pang1, 2. 1The Eye Hospital, School
of Ophthalmology and Optometry, Wenzhou
Medical College, Wenzhou, China; 2University of
Florida, Gainesville, FL; 3The Jackson Laboratory,
Bar Harbor, ME *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
197
Tuesday Posters
8:30 am – 10:15 am
2703 — A0025 Differentiating vitreous
proteomes in proliferative diabetic retinopathy
using high-performance liquid chromatography
coupled to tandem mass spectrometry. Hao
Wang, L. Feng, F. Wang. ophthalmology, Shanghai
tenth People’s Hospital, Shanghai, China
Exhibit Hall A0151-A0190
Tuesday Posters
8:30 am – 10:15 am
2716 – 2737 – Tuesday – Posters
2716 — A0160 Enhancement of AAV2mediated retinal transduction in diabetic rats.
Nundehui Díaz-Lezama1, Z. Wu2, M. Ramírez1, B.
Moreno-Carranza1, G. Martinez de la Escalera1,
P. Colosi2, C. Clapp1. 1Instituto de Neurobiología,
Universidad Nacional Autónoma de México
(UNAM), Querétaro, Mexico; 2Neurobiology,
Neurodegeneration and Repair Laboratory, National
Eye Institute, National Institutes of Health,
Bethesda, MD
2723 — A0167 AAV-mediated gene therapy
restores cone function in the Cnga3/Nrl double
knockout mouse. Ji-Jing Pang1, Y. Tao1, 2, S. L.
Boye1, J. Li1, W. Deng1, X. Ding3, S. Michalakis4,
M. Biel4, S. E. Boye1, W. W. Hauswirth1.
1
Ophthalmology, University of Florida, Gainesville,
FL; 2Fourth Military Medical University, Xi’an,
China; 3University of Oklahoma Health Sciences
Center, Oklahoma City, OK; 4University of Munich,
Munich, Germany *CR
2717 — A0161 Ex vivo gene transfer of antiangiogenic soluble Flt-1 to corneal epithelial cells
sheets suitable for ocular surface reconstruction.
Jingbo Liu, V. H. Guaiquil, A. Liu, M. Rosenblatt.
Margaret M. Dyson Vision Research Institute, Weill
Cornell Medical College, New York, NY
2724 — A0168 Gene Delivery of ATP6 by A
Mitochondrial Targeting Sequence Modification
of AAV Capsid VP2 Rescues Cells with Mutated
T8993G MtDNA Responsible for Neuropathy
Ataxia and Retinitis Pigmentosa. Huijun Yuan1,
H. Yu1, J. Guy1, 2. 1University of Miami Miler School
of Medicine, Miami, FL; 2Bascom Palmer Eye
Institute, Miami, FL
2718 — A0162 Comparison of AdenoAssociated Viral Vector Serotypes for Gene
Transfer To Corneal Endothelial Cells. Thomas
A. Fuchsluger1, C. Mueller2, R. Dana3. 1Department
of Ophthalmology, Heinrich-Heine-University
Hospital, Dusseldorf, Germany; 2Pediatrics and
Gene Therapy Center, University of Massachusetts
Medical School, Worcester, MA; 3Dept. of
Ophthalmology, Schepens Eye Research Institute,
Boston, MA *CR
2719 — A0163 Effect of intraviteal injection
of AAV9.TGFβ2 on the expression of anterior
segment and intraocular pressure in rabbits.
Guilin Zhan, C. Long, A. Shepard, N. Jacobson,
R. Ornberg, Y. Wang, S. Cao, G. Prasanna.
Ophthalmology Res./Glaucoma Res., Novartis
Institutes for Biomedical Res., Fort Worth, TX *CR
2720 — A0164 Changes in S and L/M cone
opsin expression in the RPE65 dog model
following AAV mediated gene addition therapy.
Knut Stieger1, D. Klein1, A. Mendes-Madeira2, F.
Rolling2, S. Haverkamp3, B. Lorenz1. 1Department of
Ophthalmology, Justus-Liebig-University Giessen,
Giessen, Germany; 2Institut UMR 1089, Institut de
Recherche Thérapeutique 1, Nantes, France; 3Max
Planck Institute for Brain Research, Frankfurt,
Germany *CR
2721 — A0165 Natural History of the CNGB3/
NRL Double Knock-Out Mouse. William W.
Hauswirth, S. Min, S. L. Boye, D. Kasuga, Q. Ruan,
J. Sun, M. Phan, S. E. Boye, C. N. Kay. Dept. of
Ophthalmology, University of Florida College of
Medicine, Gainesville, FL *CR
2722 — A0166 Subretinal Injection of AAV2CMV-hEPO to Diabetic Retina is Protective
and Safe. Hua Xu1, 3, J. Zhang1, 2, L. Zhang2, L.
Gu1, 3, L. Lu1, 2, W. Li1, 4, G. Xu1, 2. 1Department
of Ophthalmology of Shanghai Tenth People’s
Hospital, and Tongji Eye Institute, Tongji
University School of Medicine (TUSM), Shanghai,
China; 2Department of Regenerative Medicine
and Stem Cell Research Center, Tongji University
School of Medicine (TUSM), Shanghai, China;
3
Tongji University School of Life Sciences and
Technology, Shanghai, China; 4Department of
Ophthalmology, Drexel University College of
Medicine, Philadelphia, PA
2725 — A0169 Effective delivery of small
interfering RNA to mouse cornea by eye drops.
Kaili Wu, Z. Li, F. Duan, J. Liao, Q. Huang.
Zhongshan Ophthalmic Center, Sun Yat-Sen Univ,
Guangzhou, China
2726 — A0170 Targeted Suppression of Human
Adenovirus DNA-polymerase Gene by RNA
Interference. Natalia Nikitenko1, A. Klimova1,
P. Spirin1, P. Groitl2, T. Speiseder2, V. Prassolov1.
1
Engelhardt Institute of Molecular Biology Russian
Academy of Sciences, Moscow, Russian Federation;
2
Heinrich Pette Institute - Leibniz Institute for
Experimental Virology, Hamburg, Germany
2727 — A0171 Evaluation of Influenza
Associated Virus (IAV)-based replicationincompetent for Ocular Delivery of microRNAS.
Coralia C. Luna1, B. tenOever2, G. Li1, S. Schmid2,
P. Challa1, D. L. Epstein1, J. Qiu1, P. Gonzalez1.
1
Ophthalmology, Duke University, Durham, NC;
2
Microbiology, Mount Sinai School of Medicine,
New York, NY
2728 — A0172 Long-Term Protection by
Complement Regulatory Protein Crry in
a Mouse Model Of Lipofuscin-Mediated
Retinal Degeneration. Shanta Sarfare, A. Kim,
Z. Jiang, M. B. Lloyd, S. R. Eddington, S. Habib,
D. Bok, S. Nusinowitz, G. H. Travis, R. A. Radu.
Ophthalmology, Jules Stein Eye Institute, Los
Angeles, CA
2729 — A0173 Testing siRNAs for use in
a rapidly progressing model of autosomal
dominant retinitis pigmentosa. Brian P.
Rossmiller, H. Mao, A. S. Lewin. Department of
Molecular Genetics and Microbiology, University
of Florida, Gainesville, FL *CR
2730 — A0174 Gene Therapy for CEP290associated LCA in Patient-Derived Induced
Pluripotent Stem Cells. Erin R. Burnight1, E. E.
Kaalberg1, M. E. Eyestone1, J. Hoffman1, C. M.
Haas1, R. F. Mullins1, E. M. Stone1, 2, B. A. Tucker1.
1
Ophthalmology and Visual Sciences, University
of Iowa, Iowa City, IA; 2HHMI Investigator, Iowa
City, IA *CR
2731 — A0175 AAV8 mediated gene therapy
for corneal cystinosis. Duy H. Nguyen1, H. Du1, M.
Bedell1, S. Grob1, J. Luo1, J. L. Quach1, P. Shaw1, S.
Cherqui2, K. Zhang1. 1Ophthalmology, University of
California San Diego, La Jolla, CA; 2Molecular and
Experimental Medicine, Scripps Research Institute,
La Jolla, CA *CR
2732 — A0176 Tropisms of AAV for Subretinal
Delivery to the Neonatal Mouse Retina and
Its Application for In Vivo Rescue of the Crx
Knockout Retina. Satoshi Watanabe1, 2, R. Sanuki1,
S. Ueno3, T. Furukawa1. 1Laboratory for Molecular
and Developmental Biology, Institute for Protein
Research, Osaka University and JST, CREST,
Suita, Japan; 2Department of Molecular Genetics,
Kyoto University Graduate School of Medicine,
Kyoto, Japan; 3Department of Ophthalmology,
Nagoya University Graduate of School of Medicine,
Nagoya, Japan
2733 — A0177 Accessibility of Retinal Cells
to Different AAV Serotypes After Intravitreal
Injection in Old Versus New World Primates.
Maureen Neitz1, A. E. Hendrickson1, M. Lukason2,
J. Neitz1, D. E. Possin1, G. Abedi3, J. Huang1,
A. Scaria2, S. Wadsworth2. 1Ophthalmology,
University of Washington, Seattle, WA; 2Gene
Therapy, Genzyme-Sanofi, Framingham, MA;
3
Ophthalmology & Optometry, University of Texas,
San Antonio, TX *CR
2734 — A0178 Transfer of TACSTD2 Gene
into Corneal Epithelial Cells of Gelatinous DropLike Corneal Dystrophy and Its Functional
Expression. Toru Matsunaga1, 2, K. Kitazawa3, K.
Yamasaki4, T. Sato1, 2, Y. Watanabe1, 2, T. Funaki1,
A. Matsuda1, N. Ebihara1, S. Kawasaki3, A.
Murakami1. 1Ophthalmology, Juntendo University
School of Medicine, Tokyo, Japan; 2Reserch and
Development, SEED Co., Ltd., Saitama, Japan;
3
Ophthalmology, Kyoto Prefecutural University
School of Medicine, Kyoto, Japan; 4Biomedical
Engineering, Faculty of Life and Medical Sciences,
Doshisha University, Kyoto, Japan *CR, f
2735 — A0179 Transduction Profile of Anterior
Chamber-injected Capsid Mutated Selfcomplementary Adeno-Associated Virus Type 2
in Rodents. Barbara Bogner1, S. L. Boye2, S. Min2,
J. J. Peterson2, Q. Ruan2, V. Chiodo2, R. C. Ryals2,
H. A. Reitsamer1, W. W. Hauswirth2, S. E. Boye2.
1
Ophthalmology/Optometry, Paracelsus Medical
University, Salzburg, Austria; 2Ophthalmology,
University of Florida, Gainesville, FL *CR
2736 — A0180 Glycosidic Enzymes
Enhance Retinal Transduction Following
Intravitreal Delivery of AAV2. Jasmina CehajicKapetanovic1, 2, A. Allen2, P. N. Bishop1, R. Lucas2.
1
Institute of Human Development, University
of Manchester, Manchester, United Kingdom;
2
Faculty of Life Sciences, University of Manchester,
Manchester, United Kingdom
2737 — A0181 Antisense oligonucleotide-based
therapy for CEP290-associated LCA. Alejandro
Garanto, F. P. Cremers, R. W. Collin. Human
Genetics, Radboud University Nijmegen Medical
Centre, Nijmegen, Netherlands *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
198
Tuesday – Posters – 2738 – 2762
2738 — A0182 Mitochondrial Gene Therapy
for G11778A LHON: Safety of Human ND4
in Nonhuman Primates and Expression in Ex
Vivo Human Eyes. Rajeshwari D. Koilkonda1, D.
T. Tse1, W. W. Hauswirth2, V. Chiodo2, S. L. Boye2,
M. Neuringer3, T. Stout3, J. Guy1. 1Ophthalmology,
Bascom Palmer Eye Institute, University of MiamiMiller School of Medicine, Miami, FL; 2Department
of Ophthalmology, University of Florida, College
of Medicine, Gainesville, FL; 3Oregon Health and
Science University, Beaverton, OR *CR
2739 — A0183 Dual Adeno-associated virus
vectors for large cDNA gene replacement
therapy. Frank M. Dyka, S. L. Boye, V. Chiodo,
S. E. Boye, W. W. Hauswirth. Ophthalmology,
University of Florida, Gainesville, FL *CR
2740 — A0184 A comparison of the effects
of subretinal injection of scAAV2-CMV-GFP
on retinal structure, visual function, and GFP
expression by two injectors. Hui Li, S. H. Poor,
C. E. Bigelow, V. Choi, S. Hanks, J. Vrouvlianis,
M. Maker, S. Louie, S. Liao, B. D. Jaffee. Novartis
Institutes for Biomedical Research, Cambridge, MA
*CR
2742 — A0186 Functional Biomarkers For
Successful Molecular Therapy Of The Outer
Retina In Retinal Degenerations. Vithiyanjali
Sothilingam1, M. Garcia Garrido1, C. Seide1, S.
Koch2, S. Michalakis2, M. Biel2, N. Tanimoto1, M.
W. Seeliger1. 1Division of Ocular Degeneration, Ctr
for Ophthal Inst for Ophthalmic Rsch, Tuebingen,
Germany; 2Department of Pharmacy-Centre for
Drug Research, Center for Integrated Protein
Science Munich (CIPSM), Munich, Germany
2743 — A0187 In Vivo Quantification Of
Photoreceptor Transduction Efficiency Using
Novel Modified AAV Capsids. Renee C. Ryals,
C. N. Kay, S. L. Boye, S. Min, A. E. Ayala, W. W.
Hauswirth, S. E. Boye. Ophthalmology, University
of Florida, Gainesville, FL *CR
2744 — A0188 The LentiVector Gene Therapy
Platform for Ocular Disease: a clinical update.
Kyriacos Mitrophanous, S. Ellis, J. Miskin, K. M.
Binley, M. Kelleher, C. A. Lucas, S. M. Naylor.
Oxford BioMedia (UK) Ltd, Oxford, United
Kingdom *CR, f
®
2745 — A0189 Assessment of Intravitreal AAVTEAD4 Isoforms in the OIR Model. Matthew
Hartzell, A. J. Stempel, T. J. McFarland, B.
Appukuttan, T. Stout. Opthalmology, Oregon Health
& Science Univ, Portland, OR *CR
Exhibit Hall B0001-B0038
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Visual Psychophysics / Physiological Optics
313 Low Vision Rehabilitation
Moderator: Gislin Dagnelie
2747 — B0001 Measuring reading speed:
a comparison of reading paragraphs and
single sentences. Susanne Trauzettel-Klosinski,
E. K. Altpeter, T. Marx, N. Nguyen. Centre
for Ophthalmology, University of Tuebingen,
Tuebingen, Germany
2748 — B0002 Properties of the Dutch Reading
Charts. Ger V. Van Rens, T. Verkerk Brussee, E.
Klerkx, R. V. Nispen. Ophthalmology, Free Univ
Amsterdam Medical Ctr, Amsterdam, Netherlands
2749 — B0003 iPad vs Closed Circuit
Television Low Vision Reading Rates and
Preferences. Alex Zemke1, 2, D. Irvine1, 2, J. Coalter1,
W. M. Jay3. 1Spectrios Institute for Low Vision,
Wheaton, IL; 2The Chicago Lighthouse for People
Who are Blind or Visually Impaired, Chicago, IL;
3
Loyola University Chicago, Maywood, IL
2750 — B0004 Reading performance in
low-vision patients using a low-cost portable
reading system prototype. Adriana Berezovsky,
V. R. dos Santos, N. N. Cavascan, S. R. Salomao.
Departamento de Oftalmologia, Universidade
Federal de Sao Paulo, Sao Paulo, Brazil
2751 — B0005 Improving reading speed in
peripheral vision through a non-task-based
training. Deyue Yu. College of Optometry, The
Ohio State University, Columbus, OH
2752 — B0006 Effect of Decreased Lighting
on Visual Acuity in Normal Subjects Donald
C. Fletcher MD; California Pacific Medical
Center Dept. of Ophthalmology and SmithKettlewell Eye Research Institute. Laura Walker
Renninger; Smith-Kettlewell Eye Research
Institute. David T. Hamilton. 1Low Vision
Research, CPMC, San Francisco, CA; 2Low Vision
Research, Smith-Kettlewell Eye Research Institute,
San Francisco, CA
2753 — B0007 Luminance in Acuity and
Reading Performance of Low Vision Patients.
Donald C. Fletcher1, 2, L. Renninger2, R. A.
Schuchard3. 1Ophthalmology, California Pacific
Medical Center, San Francisco, CA; 2SmithKettlewell Eye Research Institute, San Francisco,
CA; 3VAPAHCS, Stanford University, Palo Alto,
CA *CR
2754 — B0008 SK-Read performance as a
predictor of handwriting difficulty in low vision
patients. Ken Downes1, 2, D. C. Fletcher1, 2, L.
Renninger2. 1Ophthalmology, California Pacific
Medical Center, San Francisco, CA; 2SmithKettlewell Eye Research Institute, San Francisco,
CA *CR
2755 — B0009 Using Mirametrix Eye Tracking
Technology to Evaluate Eccentric Reading.
Joseph J. Zinkovich1, E. Anderson2, E. Doxtader2,
M. Nguyen2. 1School of Optometry, Massachusetts
College of Pharmacy and Health Sciences,
Worcester, MA; 2Arizona College of Optometry,
Midwestern University, Glendale, AZ
2756 — B0010 Search during Word
Recognition in Visual Noise with the Laser
Scanning Digital Camera Stimulator. Elli J.
Kollbaum1, C. A. Clark1, B. P. Haggerty1, B. L.
Petrig1, 2, A. E. Elsner1, 2. 1School of Optometry,
Indiana University, Bloomington, IN; 2Aeon
Imaging, LLC, Bloomington, IN *CR
2757 — B0011 Low-power Half Lens Prisms
For The Rehabilitation Of Hemianopia.
Giovanni Sato1, R. Rizzo1, G. M. Villani2, 1. 1Centro
di Riabilitazione Visiva, Ulss16, Ospedale S.
Antonio, Padova, Italy; 2Ophthalmology, Centro
Riabilitazione Ipovedenti e Microperimetria CRIM, Castel d’Azzano, Italy *CR
2758 — B0012 Peripheral Prisms Increase
Blindside Eye And Head Scanning Movements
During Outdoor Walking In Hemianopes:
Preliminary Results. Matteo Tomasi, J. Churchill,
J. Wiegand, K. Houston, E. Peli, A. R. Bowers, G.
Luo. Schepens Eye Research Institute, Boston, MA
*CR
2759 — B0013 Perceptual-motor adaptation
in hemianopes wearing peripheral prisms is
possible: Preliminary results. Kevin Houston1, 2,
J. Churchill2, J. Wiegand2, E. Peli2, 3, G. Luo2,
3
, R. B. Goldstein2, 3, R. L. Woods2, 3, A. R.
Bowers2, 3. 1Ophthalmology, Massachusetts Eye
and Ear, Boston, MA; 2Schepens Eye Research
Institute, Massachusetts Eye and Ear, Boston,
MA; 3Ophthalmology, Harvard Medical School,
Cambridge, MA *CR
2760 — B0014 Contrast Sensitivity (CS) testretest reliability and consistency with Vector
Vision CSV-1000LVand CSV-1000HGT in
patients with Albinism. Maria Cucuras1, S. Kelly2,
F. Saeed3. 1Illinois College of Optometry, Chicago,
IL; 2Illinois College of Optometry, Chicago, IL;
3
Illinois College of Optometry, Chicago, IL
2761 — B0015 Analyses of contrast sensitivity
assessments over time: A pilot study. Xi Chen,
L. A. Lesmes, J. Wallis, T. S. Wallis, M. Jackson, P.
Bex. Department of Ophthalmology, Massachusetts
Eye and Ear Infirmary, Boston, MA *CR
2762 — B0016 The Reliability of the quick CSF
Method for Contrast Sensitivity Assessment in
Low Vision. Luis A. Lesmes, J. Wallis, M. Jackson,
P. Bex. Dept of Ophthalmology, Mass Eye and Ear
Infirmary, Harvard Medical School, Boston, MA
*CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
199
Tuesday Posters
8:30 am – 10:15 am
2741 — A0185 Glaucoma-GT, a novel gene
therapy treatment for primary open-angle
glaucoma. Scott Ellis, K. M. Binley, V. Scripps,
S. Iqball, S. M. Naylor, K. Mitrophanous. Oxford
BioMedica (UK) Limited, Oxford, United Kingdom
*CR
2746 — A0190 AAV-mediated Combination
Therapy of Neurotrophic and Anti-Apoptotic
Factors in a Mouse Model of Inherited Retinal
Degeneration. Cecile Fortuny1, L. C. Byrne1, D.
Dalkara2, T. S. Lee1, B. Ozturk1. 1HWNI, Flannery
Lab, University of California, Berkeley, Berkeley,
CA; 2Institut de la Vision, Paris, France
Tuesday Posters
8:30 am – 10:15 am
2763 – 2785 – Tuesday – Posters
2763 — B0017 Contrast Sensitivity
Measurement in the Pediatric Low Vision
Setting. Gregory R. Hopkins, A. M. Brown.
College of Optometry, The Ohio State University,
Columbus, OH *CR
2771 — B0025 Evaluating the Effectiveness of
Low Vision Rehabilitation in Children. Vijaya
K. Gothwal, R. Sumalini, S. Bharani. Meera and L
B Deshpande Centre for Sight Enhancement, L V
Prasad Eye Institute, Hyderabad, India
2764 — B0018 Feedback measures for a
wearable visual aid designed for the visually
impaired. Aminat Adebiyi1, J. D. Weiland1, 2, C.
Zhang1, 3, K. Thakoor4. 1Biomedical Engineering,
University of Southern California, Los Angeles,
CA; 2Ophthalmology, University of Southern
California, Los Angeles, CA; 3Electrical
Engineering, University of Southern California, Los
Angeles, CA; 4Neuroscience Graduate Program,
University of Southern California, Los Angeles,
CA *CR
2772 — B0026 Quantification and evaluation
of bivariate contour ellipse area (BCEA) in
different diseases after rehabilitation. Francesca
Verboschi, V. De Rosa, C. Di Crescenzo, G. Rea, M.
Mafrici, D. Domanico, E. M. Vingolo. University of
Rome “La Sapienza”, Latina (LT), Italy
2765 — B0019 Locomotion in Low Luminance
with Non Immersive Head Mounted Device for
Patients with Night Blindness. Coen Cecilia1, C.
Chauvire1, G. Le Gall2, A. Koustanai1, M. Swital2,
L. Bernardini1, P. Chaumet-Riffaud1, 3, S. MohandSaid1, J. A. Sahel1, A. B. Safran1. 1INSERM, U968;
UPMC Univ Paris 06, UMR_S 968, Institut de la
Vision; CNRS, UMR_7210; CHNO des QuinzeVingts, INSERM-DHOS CIC 503, Paris, France;
2
Essilor R&D Internationnal, Paris, France; 3Univ
Paris Sud, AP-HP, CHU Bicêtre, EA 4046, Paris,
France *CR
2766 — B0020 Object identification by retinitis
pigmentosa patients in dim light, using a Head
Mounted Display. Marion Swital2, C. Cecilia1, C.
Chauvire1, A. Koustanai1, G. Le Gall2, S. Kime1, P.
Chaumet-Riffaud1, 3, S. Mohand-Said1, J. A. Sahel1,
A. B. Safran1. 1INSERM, U968; UPMC Univ Paris
06, UMR_S 968, Institut de la Vision; CNRS,
UMR_7210; CHNO des Quinze-Vingts, INSERMDHOS CIC 503, Paris, France; 2R&D, Essilor
International, Paris, France; 3Univ Paris Sud, APHP, CHU Bicêtre, EA 4046, Paris, France *CR
2767 — B0021 Sensitivity recovery following a
bleach; a dual “smiley” arc stimulus technique
for studying abnormal dark adaptation. Humza
J. Tahir1, I. J. Murray1, D. Carden1, N. R. Parry2.
1
Faculty of Life Sciences, University of Manchester,
Manchester, United Kingdom; 2University of
Manchester Health Science Research Centre and
Vision Science Centre, Manchester Royal Eye
Hospital, Manchester, United Kingdom
2768 — B0022 Darks are detected faster and
more accurately than lights in normal subjects
and patients with moderate glaucoma. Linxi
Zhao, M. W. Dul, J. M. Alonso, S. J. Komban, Q.
Zaidi. SUNY College of Optometry, New York, NY
2769 — B0023 Is visual exploration training
beneficial in tunnel vision? Iliya V. Ivanov, A.
F. Vollmer, N. Nguyen, S. Trauzettel-Klosinski.
University of Tuebingen, Tuebingen, Germany
2770 — B0024 Is Vernier Acuity more Sensitive
than Grating Acuity to Visual Impairment in
Adolescents? Huizi Kelly Yin1, B. S. Kran2, D.
Wright3, D. D. Bent3, L. Deng2, D. L. Mayer2.
1
Illinois College of Optometry, Chicago, IL; 2New
England College of Optometry, Boston, MA;
3
Perkins School, Watertown, MA
2773 — B0027 Comparison of Fixation
Stability Measured by Laser Scanning Digital
Camera and DLP-Cam. Benno L. Petrig1, 2, J.
Clendenon2, L. Ensman1, M. S. Muller2, A. E.
Elsner1, G. Y. Ozawa3, T. V. Litvin3, J. A. Cuadros3,
T. Roy3, D. Li3. 1School of Optometry, Indiana
University, Bloomington, IN; 2Aeon Imaging
LLC, Bloomington, IN; 3School of Optometry, UC
Berkeley, Berkeley, CA *CR
2774 — B0028 Do visually impaired
participants hear better? An evaluation of self
report using a modified version of Speech,
Spatial and Qualities of Hearing Scale. Shahina
Pardhan1, S. Cirstea1, A. Kolarik2, 1, B. Moore2.
1
Vision and Eye Research Unit (VERU), Anglia
Ruskin University, Cambridge, United Kingdom;
2
Department of Psychology, University of
Cambridge, Cambridge, United Kingdom
2775 — B0029 An Object Localization
and Feedback System. Nii Tete Mante1, 2, G.
Medioni2, A. R. Tanguay1, 4, T. Dinh2, F. E. Sahin4,
P. J. Nasiatka4, J. D. Weiland1, 3. 1Department of
Biomedical Engineering, University of Southern
California, Los Angeles, CA; 2Department of
Computer Science, University of Southern
California, Los Angeles, CA; 3Department of
Opthamology, University of Southern California,
Los Angeles, CA; 4Department of Electrical
Engineering, University of Southern California, Los
Angeles, CA *CR
2776 — B0030 Magnification, Field of View and
Depth of Field in Low Vision Aids and Optical
Instruments. Ian L. Bailey. School of Optometry,
University of California, Berkeley, Berkeley, CA
2777 — B0031 Preference pattern of low
vision aids in glaucoma-redefining guidelines.
Aparna Rao, S. Monira, M. Chowdhury. Glaucoma
Services, LV Prasad Eye Institute, Patia, India,
Bhubaneswar, India
2778 — B0032 Sustained benefits of
Therapeutic Tinted Contact Lenses (CL) in
patients with Albinism. Faheemah Saeed1, D. G.
Schlange2, T. Najafi3. 1Illinois College of Optometry,
Chicago, IL; 2Illinois College of Optometry,
Chicago, IL; 3Illinois College of Optometry,
Chicago, IL
2779 — B0033 Evaluating center of pressure
(CoP) measures of postural stability in low
and normal vision using the Nintendo Wii
Balance BoardTM (WBB). Pamela E. Jeter1, J.
Gu2, J. E. Goldstein1, A. K. Bittner1, G. Dagnelie1.
1
Ophthalmology, Johns Hopkins University,
Baltimore, MD; 2Electrical & Computer
Engineering, Carnegie Mellon University,
Pittsburgh, PA
2780 — B0034 Low vision and work
opportunities. Jørn Kalleberg1, I. Langeggen2.
1
NAV Buskerud, Drammen, Norway; 2Buskerud
University College, Kongsberg, Norway
2781 — B0035 The effect of an Adapted
Day Centre on Physical and Psychological
Well-Being in Older Adults with Low Vision.
Walter Wittich1, 2, C. Murphy3, 2, D. Mulrooney1, 2.
1
Research, MAB-Mackay Rehabilitation Centre,
Montreal, QC, Canada; 2CRIR, Montreal, QC,
Canada; 3School of Optometry, University of
Montreal, Montreal, QC, Canada
2782 — B0036 Vision, Demographic Factors,
and Motor Vehicle Collisions in Bioptic
Drivers. Bradley E. Dougherty1, R. E. Flom1, M.
A. Bullimore2, T. W. Raasch1. 1Optometry, Ohio
State University, Columbus, OH; 2Optometry, The
University of Houston, Houston, TX *CR
2783 — B0037 Effects of patient traits on
physician-predicted low vision outcomes.
Tiffany L. Chan, R. W. Massof, J. E. Goldstein.
Ophthalmology, Johns Hopkins University School
of Medicine, Baltimore, MD
2784 — B0038 An Inventory of Visually Guided
Activities Self-reported by Individuals with
Profound Visual Impairment. Gislin Dagnelie1, P.
E. Jeter1, L. Dalvin2, E. R. Arnold1. 1Ophthal-Lions
Vision Cntr, Johns Hopkins Univ, Baltimore, MD;
2
NE Ohio Medical Univ, Rootstown, OH
Exhibit Hall B0039-B0093
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Retina
314 Macular Disease other than AMD I
Moderators: Timothy W. Olsen and Judy E. Kim
2785 — B0039 Anterior chamber depth in
eyes with central serous chorioretinopathy.
Jong-Hyun Oh1, J. Oh2, Y. Choi2, S. Kim2, K.
Huh2. 1Ophthalmology, Dongguk University
Ilsan Hospital, Goyang, Republic of Korea;
2
Ophthalmology, Korea University College of
Medicine, Seoul, Republic of Korea
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
200
Tuesday – Posters – 2786 – 2811
2786 — B0040 Clinical Course of Unoperated
Eyes with Vitreofoveal Traction. Vishak J.
John1, H. W. Flynn1, W. E. Smiddy1, A. Carver2,
R. Leonard2, H. Tabandeh3, D. S. Boyer3.
1
Ophthalmology, Bascom Palmer Eye Institute,
Miami, FL; 2Ophthalmology, University of
Oklahoma, Oklahoma City, OK; 3Retina, Retina
Vitreous Associates Medical Group, Los Angeles,
CA *CR
2795 — B0049 Clinical evaluation of foveal
sparing in patients with Stargardt disease.
Ramon A. van Huet1, S. C. Westeneng -van Haaften1,
M. Muhamad1, F. P. Cremers2, L. H. Hoefsloot2,
B. Klevering1, C. B. Hoyng1. 1Ophthalmology,
Radboud University Nijmegen Medical Centre,
Nijmegen, Netherlands; 2Human Genetics, Radboud
University Nijmegen Medical Centre, Nijmegen,
Netherlands
2787 — B0041 Comparison of A-scan
ultrasound and partial coherence laser
interferometry: axial length in idiopathic
macular hole. Jung Yeul Kim, W. Kim, K. Nam, H.
Lee, Y. Shin. Ophthalmology, Chungnam Natl Univ
Hosp, Daejeon, Republic of Korea
2796 — B0050 Intravitreal Bevacizumab
for Choroidal Neovascularization due to
Pathological Myopia: Long-term Outcomes.
Valentina Sarao, D. Veritti, S. Macor, P. Lanzetta.
Department of Ophthalmology, University of Udine,
Udine, Italy *CR
2788 — B0042 Factors that Predict Outcomes
of Macular Hole Repair. Jack Shao, L. T. Xu, O. S.
Punjabi, J. P. Ehlers, S. K. Srivastava, P. K. Kaiser.
Cole Eye Institute, Cleveland Clinic, Cleveland,
OH *CR
2797 — B0051 Comparison of efficacy, safety
and costs between half-fluence and half-dose
photodynamic therapy for Chronic Central
Serous Chorioretinopathy. Massimo Nicolo, C.
M. Eandi, C. Alovisi, C. E. Traverso. Di.N.O.G.Mi
- Universita’ di Genova, University Eye Clinic IRCCS San Martino IST, Genova, Italy
2789 — B0043 Correlation of pattern
electroretinogram and visual acuity in idiopathic
epiretinal membrane. Ji Eun E. Lee, H. Kim,
S. Kim, J. Park, I. Byon. Ophthalmology, Pusan
National Univ Hospital, Busan, Republic of Korea
2791 — B0045 One-year outcome of two
different initial doses of intravitreal ranibizumab
for myopic choroidal neovascularization.
Ya-Hsin Kung1, 2, T. Wu1, 2. 1Ophthalmology,
Kaohsiung Veterans General Hospital, Kaohsiung,
Taiwan; 2School of medicine, National Yang-Ming
University, Taipei, Taiwan
2792 — B0046 Morphologic Choroidal
Changes in Dome Shaped Macula Combining
Indocyanine Green Angiography (ICGA)
and Spectral Domain Optical Coherence
Tomography (SD-OCT). Francesco Viola, L.
Dell’Arti, E. Benatti, C. Mapelli, G. Barteselli,
M. Serafini, R. Ratiglia. University of Milan,
Fondazione IRCCS Ca’ Granda Ospedale
Policlinico, Milan, Italy
2793 — B0047 Quantitative Measurement of
Color Discrimination in Cone-Rod Dystrophies
and Inherited Maculopathy. Brett G. Jeffrey1, W.
M. Zein1, B. Falsini1, 2, D. L. Nigam1, P. A. Sieving1.
1
National Eye Institute/NIH, Bethesda, MD;
2
Catholic University, Rome, Italy
2794 — B0048 Prevalence of Vitreomacular
Interface Disease and Candidates for
Ocriplasmin Treatment. Lucy T. Xu, O. S. Punjabi,
J. Shao, J. P. Ehlers, S. K. Srivastava, P. K. Kaiser.
Cole Eye Institute, Cleveland Clinic Foundation,
Cleveland, OH *CR
2799 — B0053 Foveal Contour after Pars
Plana Vitrectomy for Idiopathic Macular Hole.
Royce W. Chen1, 2, P. Sherwood2, S. Mukkamala2,
F. S. Siringo2, S. Chang2. 1Ophthalmology, Bascom
Palmer Eye Institute, Miami, FL; 2Ophthalmology,
Columbia University, New York, NY *CR
2800 — B0054 Very early disease
manifestations in macular telangiectasia type 2.
Tjebo F. Heeren, F. G. Holz, P. Charbel Issa.
Department of Ophthalmology, University of Bonn,
Bonn, Germany *CR
2801 — B0055 Familial occurence of chronic
central serous chorioretinopathy. Myrte B.
Breukink1, A. I. Den Hollander1, 2, J. E. Keunen1, C.
B. Hoyng1, C. J. Boon1, 3. 1Ophthalmology, Radboud
University Nijmegen Medical Centre, Nijmegen,
Netherlands; 2Human Genetics, Radboud University
Nijmegen Medical Centre, Nijmegen, Netherlands;
3
Oxford Eye Hospital, University of Oxford, John
Radcliffe Hospital, Oxford, United Kingdom
2802 — B0056 Notching of tissue after macular
hole surgery : An abrupt alteration in inner
contour of parafoveal tissue associated with
foveal tissue elongation. Jae Hui Kim, S. Kang,
J. Kim. Ophthalmology, Samsung Medical Center,
Seoul, Republic of Korea, Seoul, Republic of Korea
*CR
2804 — B0058 Characteristics of Fundus
Angiography and Optical Coherence
Tomography in Patients with Focal Choroidal
Excavation Complicated by Central Serous
Chorioretinopathy. Mihoko Suzuki, F. Gomi, M.
Sawa, K. Nishida. Ophthalmology, Osaka Univ
Medical School, Suita, Japan *CR
2805 — B0059 The early visual changes
with hydroxychloroquine (HCQ) usage
detected with multifocal ERG (mfERG) versus
spectral domain OCT (SDOCT) and 10-2 field
testing. Anh-Danh T. Phan1, 2, J. Eikenberry1,
L. A. McNulty1, 2. 1Ophthalmology, Indiana
University / Glick Eye Institute, Indianapolis,
IN; 2Ophthalmology, Indiana University / Visual
Electrophysiology Laboratory, Indianapolis, IN
2806 — B0060 Comparison of outcomes
between 20, 23 and 25 gauge vitrectomy for
idiopathic macular hole. Fatma M. Dihowm1,
M. MacCumber2. 1Graduate College, Rush
University and Medical Center, CHICAGO, IL;
2
Ophthalmology, Rush University Medical Center,
CHICAGO, IL *CR
2807 — B0061 Evaluation of Retinal
Function in Patients with Retinal Toxicity from
Hydroxychloroquine after Drug Cessation.
James Osher1, 2, R. Katira1, 2, J. S. Lyons2, 3. 1Retina
Group of Washington, Washington D.C., DC;
2
Dept of Ophthalmology, Washington Hospital
Center, Washington D.C., DC; 3Ophthalmology,
Georgetown University, Washington D.C., DC
2808 — B0062 Long-Term Follow-Up Results
of Idiopathic Epiretinal Membrane. Ik Soo Byon,
K. Pak, S. Park, J. E. Lee. Ophthalmology, Pusan
National Univ Hosp, Busan, Republic of Korea
2809 — B0063 Macular sensitivity and
structure in idiopathic epiretinal membranes 12
months after surgical treatment. Rodica Isaico,
P. Koehrer, F. Nicot, A. M. Bron, C. P. Garcher.
Department of Ophthalmology, CHU Dijon, Dijon,
France *CR
2810 — B0064 Length of preoperative
ELM and IS/OS line defect correlate with
postoperative visual acuity in patients with
idiopathic macular hole. Manzo Taguchi, S.
Ishikawa, T. Muraoka, K. Harimoto, T. Sato,
M. Takeuchi. Ophthalmology, National Defense
Medical College, Tokorozawa, Japan
2811 — B0065 Intravitreal Ranibizumab for
Acute Central Serous Chorioretinopathy. Seung
Jun Lee. Ophthalmology, Kangwon National
University Hospital, Chuncheon, Republic of Korea
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
201
Tuesday Posters
8:30 am – 10:15 am
2790 — B0044 Longitudinal Changes in
Preferred Retinal Location, Visual Function,
Fundus Autofluorescence and Retinal Structure
in Stargardt Disease. Vivienne C. Greenstein1,
M. R. Tabacaru1, E. Flynn1, R. Allikmets1, 2, S. H.
Tsang1, 2. 1Ophthalmology, Columbia University
Medical Center, New York, NY; 2Pathology & Cell
Biology, Columbia University Medical Center, New
York, NY
2798 — B0052 Visual and Anatomic Results
of the Macula Society Photodynamic Therapy
(PDT) for Central Serous Chorioretinopathy
(CSC) Retrospective Study. Jennifer I. Lim1, 7, A.
R. Glassman2, 7, L. P. Aiello3, 7, U. Chakravarthy4, 7,
C. J. Flaxel5, 7, R. F. Spaide6, 7. 1Ophthal-Eye &
Ear Infirm, University of Illinois, Chicago, IL;
2
Jaeb Center for Health Research, Tampa, FL;
3
Joslin Diabetes Center, Harvard Medical School,
Boston, MA; 4Queens University, Belfast, Ireland;
5
Casey Eye Institute, Oregon Health and Sciences
University, Portland, OR; 6Vitreous Retina Macula
Consultants, New York, NY; 7Macula Society,
Beachwood, OH *CR
2803 — B0057 Flourescein Fundus
Angiography Features of Macular Ischemia in
Radiation Retinopathy. Senthil Selvam1, 3, D. A.
Sim2, 1, P. A. Keane2, M. Fruttiger1, C. A. Egan3, M.
S. Sagoo3, A. Tufail3. 1Institute of Ophthalmology,
University College London, London, United
Kingdom; 2National Institute for Health Research
(NIHR) Biomedical Reseach Centre, Moorfields
Eye Hospital NHS Foundation Trust, London,
United Kingdom; 3Moorfields Eye Hospital NHS
Foundation Trust, London, United Kingdom *CR
2812 – 2835 – Tuesday – Posters
2812 — B0066 A Comparison of Macular
Morphology of Pediatric Versus Adult Eyes with
Epiretinal Membranes. Adam L. Rothman1, F. A.
Folgar2, A. Y. Tong1, C. A. Toth2. 1Duke University
School of Medicine, Durham, NC; 2Duke Eye
Center, Durham, NC *CR
2813 — B0067 Mineralocorticoid Receptor
Antagonism in the Treatment of Chronic Central
Serous Chorioretinopathy: First Pilot Study. Min
Zhao1, 3, E. Bousquet1, 3, F. F. Behar-Cohen1, 2. 1CRC,
Inserm U872, Team 17, Paris, France; 2Department
of Ophthalmology, Hôtel-Dieu Hospital, AP-HP,
Paris, France; 3Université René Descartes Sorbonne,
Paris, France *CR
Tuesday Posters
8:30 am – 10:15 am
2814 — B0068 Fundus autofluorescence at
macular hole predicting postoperative visual
acuities. Tasuku Yoneda, M. Yamamoto, T. Kohno,
Y. Yoshida, A. Yasui, K. Shiraki. Osaka City
University Graduate School of Medicine, Osaka
City, Japan
2815 — B0069 A Comparison of
Tests Recommended for Detecting
Hydroxychloroquine Related Retinal Toxicity.
Luz Amaro-Quireza1, 2, E. S. Abraham1, S.
H. Tsang1, D. C. Hood1, V. C. Greenstein1.
1
Ophthalmology, Columbia University, New York,
NY; 2Ophthalmology, Albert Einstein School of
Medicine, Bronx, NY *CR
2816 — B0070 Hyperautofluorescent macular
ring in a series of enhanced S-cone patients. Rony
Gelman1, 2, J. P. Greenberg2, T. Duncker2, L. A.
Yannuzzi3, 4, S. H. Tsang2. 1Ophthalmology, Doheny
Eye Institute, Los Angeles, CA; 2Ophthalmology,
Columbia University, New York, NY; 3Vitreous
Retina Macula Consultants of New York, New
York, NY; 4LuEsther T. Mertz Retinal Research
Center, Manhattan Eye, Ear, and Throat Institute,
New York, NY
2820 — B0074 Retrospective Study of Two or
More Dexamethasone Intravitreal Implant 0.7
mg Injections for Retinal Vein Occlusion. Antonio
Capone1, M. Singer2, D. G. Dodwell3, R. Dreyer4,
K. T. Oh5, D. B. Roth6, J. G. Walt7, L. C. Scott7, D.
A. Hollander7. 1Ophthal/Beaumont, Associated
Retinal Consultants, Royal Oak, MI; 2Medical
Center Ophthalmology Associates, San Antonio,
TX; 3Illinois Retina Center, Springfield, IL; 4Retina
Northwest P.C., Portland, OR; 5Associated Retinal
Consultants P.C., Traverse City, MI; 6RetinaVitreous Center, UMDNJ-Robert Wood Johnson
Medical School, New Brunswick, NJ; 7Allergan,
Inc., Irvine, CA *CR, f
2821 — B0075 Refractive errors in high
myopic eyes after phacovitrectomy. Donghyun
Jee. Ophthalmology, St. Vincent Hospital, Catholic
Medical Univ of Korea, Suwon, Republic of Korea
2822 — B0076 Macular sensitivity after
intravitreal dexamethasone implant (Ozurdex)
for retinal vein occlusion. Lea Querques1, G.
Querques2, R. Lattanzio1, M. Cascavilla1, G.
Triolo1, E. Cavallero1, P. Chiara1, M. Cicinelli1,
F. Bandello1. 1University Hospital San Raffaele,
Milan, Italy; 2of Ophthalmology, University ParisEst Creteil, Creteil, France *CR
2823 — B0077 Choroidal thickness in retinal
vein occlusion: A pilot study. Christiana Dinah1,
D. A. Sim2, P. A. Keane2, A. Tufail2, J. S. Talks1.
1
Ophthalmology, Royal Victoria Infirmary,
Newcastle, United Kingdom; 2Moorfields Eye
Hospital, London, United Kingdom *CR
2824 — B0078 Intravitreal Dexamethasone
Implant (Ozurdex) for macular edema secondary
to retinal vein occlusion: a comparative study
between recent onset and chronic edema. Emilia
Maggio, A. Polito, A. Peroglio Deiro, E. Benetti, G.
Pertile. Sacrocuore Hospital, Negrar, VR, Italy
2817 — B0071 Assessment of the outer and the
inner retina using optical coherence tomography
and the correlation with visual acuity in
idiopathic epiretinal membrane. Sung Who Park,
I. Byon, J. E. Lee. Pusan national university, Pusan,
Republic of Korea
2825 — B0079 Early treatment with
ranibizumab in severe central retinal vein
occlusion. Olga Rostaqui, A. Glacet-Bernard, N.
Massamba, J. Zerbib, F. Coscas, G. J. Coscas, E. H.
Souied. Ophthalmology, Intercommunal hospital of
Creteil, Creteil, France *CR
2818 — B0072 Systematic use of trypan blue
dye in macular pucker surgery: is it worthy?
Pauline Lallemand, C. Speeg-Schatz, T. Bourcier,
D. Gaucher. ophthalmology, CHU strasbourguniversité de Strasbourg, Strasbourg, France *CR
2826 — B0080 Visual outcomes of intravitreal
dexamethasone treatment for retinal vein
occlusions in an NHS clinic setting. Sonali
Nagendran, N. Nair, M. N. Chandran, G. Menon.
Ophthalmology, Frimley Park Hospital, Frimley,
United Kingdom *CR
2819 — B0073 Morphological description of
dome-shaped macula in myopic eyes. Violaine
Caillaux1, D. Gaucher2, V. Gualino1, P. Massin1, R.
Tadayoni1, A. Gaudric1. 1Hopital Lariboisiere, Paris,
France; 2Hopital Civil, Strasbourg, France *CR
2827 — B0081 Visual Acuity Outcomes
in Dosing Subgroups of the GALILEO and
COPERNICUS study in Patients With Macular
Edema Secondary to Central Retinal Vein
Occlusion (CRVO) Under PRN Treatment.
Amelie Pielen1, J. A. Haller2. 1University Eye
Hospital, Freiburg, Germany; 2Wills Eye Institute,
Philadelphia, United Kingdom *CR, f
2828 — B0082 The long-term effect of
intravitreal bevacizumab injection in central
serous chorioretinopathy. In-Cheon You, N. Cho,
D. Lee, M. Ahn. Research Institute of Clinical
Medicine of Chonbuk National UniversityBiomedical Research Institute, Jeonju, Republic of
Korea
2829 — B0083 Outer retinal edema as a risk
factor for poor visual outcome after bevacizumab
therapy for macular edema with branch
retinal vein occlusion. Daisuke Muramatsu1, 2,
M. Mishima1, Y. Wakabayashi1, T. Iwasaki2, S.
Ishii1, S. Kawakami1, K. Kimura1, S. Gondo1, K.
Umazume1, H. Goto1. 1Ophthalmology, Tokyo
Medical University, Tokyo, Japan; 2ophthalmology,
Tokyo Medical University Ibaraki Medical Center,
Ibaraki, Japan
2830 — B0084 Quantitative measurements of
autofluorescence in Stargardt’s disease. Tobias
Duncker1, T. R. Burke1, J. P. Greenberg1, W. Lee1, T.
Smith1, S. H. Tsang1, J. R. Sparrow1, R. Allikmets1, F.
C. Delori2. 1Ophthalmology, Columbia University,
New York, NY; 2Schepens Eye Research Institute,
Harvard Medical School, Boston, MA
2831 — B0085 Case series of Macular
Degeneration following Pars Plana Vitrectomy
using Xenon Intraocular Endoillumination.
Seung Jae Lee1, J. Seok1, H. Kyung1, S. Lee1, 2.
1
Ophthalmology, National Medical Center, Seoul,
Republic of Korea; 2Ophthalmology, Emory Eye
Center, Atlanta, GA
2832 — B0086 Fundus Autofluorescence
Patterns in Central Serous Chorioretinopathy.
Seung-Young Yu1, N. Cho2, E. Kim3, Y. Kim4,
H. Kwak1. 1Ophthalmology, Kyung Hee
University Hospital, Seoul, Republic of Korea;
2
Ophthalmology, Korea Cancer Center Hospital,
Seoul, Republic of Korea; 3Ophthalmology, Eulji
University Hospital, Daejeon, Republic of Korea;
4
Ophthalmology, Eulji General Hospital, Seoul,
Republic of Korea
2833 — B0087 Intravitreal Bevacizumab
for the treatment of Central Serous
Chorioretinopathy: follow up over 12 months.
Adam Lewis, M. Syrimi, M. N. Chandran, G.
Menon. Frimley Park Hospital, Frimley, United
Kingdom *CR
2834 — B0088 Global Patterns of Fundus
Autofluorescence in Stargardt Macular
Dystrophy. Gad Heilweil, I. Tsui, H. Hosseini, S. D.
Schwartz. Ophthalmology, Jules Stein Eye Institute
UCLA, Los Angeles, CA
2835 — B0089 Pairwise Genotype/Phenotype
Comparison to Predict Severity of ABCA4
Mutations. Crandall E. Peeler, J. Huang, S. Zahid,
N. W. Khan, K. E. Branham, K. T. Jayasundera,
J. R. Heckenlively. Ophthalmology, University of
Michigan, Ann Arbor, MI *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
202
Tuesday – Posters – 2836 – 2856
2836 — B0090 A Longitudinal Analysis of
2008-2010 Medicare Claims Data for newly
diagnosed macular holes. Sunil K. Srivastava1, P.
U. Dugel3, K. Tong2, A. J. Layton2, P. K. Kaiser1.
1
Cole Eye Institute, Cleveland Clinic, Cleveland,
OH; 2Quorum Consulting, San Francisco, CA;
3
Retina Consultants of Arizona, Phoenix, AZ *CR
2837 — B0091 Personalized Medicine:
Choloroquine Toxicity in human RPE is
Dependent on ARMS2 and HTRA1 Genotypes.
Eric Chi-Hsien Peng1, 2, Y. Li1, C. Lin3, S. H. Tsang1.
1
Bernard and Shirlee Brown Glaucoma Laboratory,
Department of Pathology and Cell Biology, College
of Physicians and Surgeons, Columbia University,
New York, NY; 2Ophthalmology, Shin Kong Wu
Ho-Su Hospital & Fu-Jen University, Taipei,
Taiwan; 3Herbert Irving Comprehensive Cancer
Center, Columbia University, New York, NY
2838 — B0092 The REPAIR Study:
Prospective, Multi-center Trial of ranibizumab
in Choroidal Neovascularization due to
Pathological Myopia - the 12 month Primary
Endpoint. Yit C. Yang. Ophthalmology,
Wolverhampton Eye Infirmary, Wolverhampton,
United Kingdom *CR
Exhibit Hall B0149-B0187
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Retina
315 Retinal Detachment I
Moderator: Daniel F. Martin
2840 — B0149 Outcomes of 25-Gauge
Vitrectomy with Relaxing Retinectomy for
Retinal Detachment with Severe Proliferative
Vitreoretinopathy. Vikram Setlur, J. I. Lim.
Ophthalmology, University of Illinois at Chicago,
Chicago, IL *CR
2841 — B0150 Giant Retinal Tear Associated
Retinal Detachment After Pars Plana
Vitrectomy: Surgical Techniques and Outcomes.
Marco A. Gonzalez1, 2, H. W. Flynn1, 2, P. Tenzel2.
1
Ophthalmology, Bascom Palmer Eye Institute,
Miami, FL; 2University of Miami, Miami, FL
2843 — B0152 Change in subfoveal choroidal
thickness following semental scleral buckling
with or without cryotherapy for rhegmatogenous
retinal detachment. Masayo Kimura, A.
Nishimura, H. Yokogawa, T. Okuda, T. Higashide,
M. Shimizu, K. Sugiyama. Ophthalmology and
Visual Science, Kanazawa University, Kanazawa,
Japan
2844 — B0153 Intravitreal gas injection
without vitrectomy for macular detachment
associated with an optic disc pit. Hideo Akiyama,
S. Kishi. Ophthalmology, Gunma university,
Maebashi, Japan
2845 — B0154 Activation of Rho GTPases
after Retinal Detachment. Jianfeng Wang1, W.
Wang2, E. Townes-Anderson1, 2. 1Neurology and
Neurosciences, New Jersey Medical School,
UMDNJ, Newark, NJ; 2Graduate School of
Biomedical Sciences, UMDNJ, Newark, NJ
2846 — B0155 Strategy for the Management of
Complex Retinal Detachments: The European
Vitreo-Retinal Society Retinal Detachment
Study. Aaron Parnes1, D. Ducournau3, J. O.
Sipperley2, R. A. Adelman1. 1Ophthalmology, Yale
University, New Haven, CT; 2Retinal Consultants of
Arizona, Phoenix, AZ; 3Clinique Sourdille, Nantes,
France
2847 — B0156 Management and Outcomes of
Bilateral Simultaneous Rhegmatogenous Retinal
Detachments. Mitul Mehta1, 2, R. A. Sisk1, C. D.
Riemann1. 1Retina, New York Eye & Ear Infirmary,
New York, NY; 2Ophthalmology, University of
Cincinnati, Cincinnati, OH
2848 — B0157 The efficacy and safety of
prophylactic cryotherapy in preventing retinal
detachment in type 1 Stickler syndrome.
Gregory S. Fincham1, L. Pasea2, C. Carroll3, A.
M. McNinch4, A. V. Poulson1, A. J. Richards4, 5,
J. D. Scott1, M. P. Snead1. 1Vitreoretinal Service,
Cambridge University NHS Foundation Trust,
Cambridge, United Kingdom; 2Centre for Applied
Medical Statistics, University of Cambridge,
Cambridge, United Kingdom; 3School of Health
and Related Research, University of Sheffield,
Sheffield, United Kingdom; 4Department of
Pathology, University of Cambridge, Cambridge,
United Kingdom; 5Regional Molecular Genetics
Laboratory, Cambridge University NHS Foundation
Trust, Cambridge, United Kingdom
2849 — B0158 Ranibizumab is a potential
prophylaxis for proliferative vitreoretinopathy,
a non-angiogenic blinding disease. Steven
Pennock1, 2, D. Kim1, 2, S. Mukai1, 2, M. Kuhnle3,
D. Chun3, J. A. Matsubara4, J. Z. Cui4, P. E. Ma4,
D. Maberley4, A. Kazlauskas1, 2. 1Schepens &
MEEI, Boston, MA; 2Harvard Medical School,
Boston, MA; 3Walter Reed Army Medical Center,
Washington, DC; 4University of British Columbia,
Vancouver, BC, Canada *CR
2850 — B0159 The usefulness of internal
limiting membrane peeling to prevent macular
pucker formation for regmatogenous retinal
detachment without foveal detachment. Masanori
Miyazaki, T. Ishibashi. Kyushu University,
Fukuoka, Japan
2851 — B0160 Membrane-bound Fas ligand
has a critical role in photoreceptor cell death in
an experimental model of retinal detachment.
Hidetaka Matsumoto1, Y. Murakami1, D.
Mantopoulos1, G. Trichonas1, J. W. Miller1, M. S.
Gregory-Ksander2, B. R. Ksander2, D. Vavvas1.
1
Massachusetts Eye and Ear Infirmary, Boston, MA;
2
Schepens Eye Research Institute, Boston, MA *CR
2852 — B0161 Effects of low-dose isotretinoin
on rates of recurrent retinal detachment
secondary to proliferative vitreoretinopathy.
Francis C. DeCroos1, M. Dollin1, N. J. London1, 2,
L. Maiale1, P. P. Storey1, J. Hsu1, J. Vander1, C. D.
Regillo1. 1Retina, Wills Eye Institute, Philadelphia,
PA; 2Retina Consultant San Diego, San Diego, CA
*CR, f
2853 — B0162 Complete prevention of retinal
detachment using prophylactic intraoperative
septated circumferential barrier laser during
macular surgery: long-term follow-up results.
June-Gone Kim, H. Yang. Ophthalmology, Asan
Medical Center, Seoul, Republic of Korea
2854 — B0163 Involvement of Autophagy in
z-VAD-FMK Induced Photoreceptor Necroptosis,
a Caspase-Independent Cell Death, after
Experimental Retinal Detachment. Kai Dong1,
X. Sun1, G. Ke2. 1Department of Ophthalmology,
Shanghai First People’s Hospital, Shanghai, China;
2
Department of Ophthalmology, the Affiliated Anhui
Provincial Hospital of Anhui Medical University,
Hefei, Anhui, China, Hefei, China
2855 — B0164 Intraocular pressure
abnormalities following silicone oil injection for
complicated retinal detachments. Hiroaki Ozaki,
J. Y. Huang, E. Uchio. Ophthalmology, Fukuoka
Univ Sch of Medicine, Jyonan-ku, Japan
2856 — B0165 Risk of intraoperative retinal
tears and recurrent rhegmatogenous retinal
detachment in eyes with previous retinal
detachment undergoing pars plana vitrectomy.
Ravi S. Singh1, D. J. Covert2, D. P. Han1.
1
Ophthalmology, Eye Institute at Medical College
of Wisconsin, Milwaukee, WI; 2Associated Retina
Consultants, Traverse City, MI
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
203
Tuesday Posters
8:30 am – 10:15 am
2839 — B0093 Assessing Photoreceptor
Structure Following Macular Hole Closure.
Sean Batson, S. Hansen, P. A. Karth, R. F. Cooper,
D. H. Scoles, D. V. Weinberg, A. Dubra, J. E. Kim,
J. Carroll, W. Wirostko. Ophthalmology, Medical
College of Wisconsin, Milwaukee, WI *CR
2842 — B0151 Symptomatic Posterior
Vitreous Detachment: The predictive value of
the posterior hyaloid face and symptomatology.
Christiane I. Falkner-Radler1, M. Cho2, A. Garf3,
A. Orlin2, R. Chan2, S. Kiss2, D. J. D’Amico2, S.
Binder1. 1Ophthalmology, The Ludwig Boltzmann
Institute of Retinology and Biomicroscopic Laser
surgery, Rudolf Foundation Clinic, Vienna, Austria;
2
Ophthalmology, Weill Cornell Medical College and
New York-Presbyterian Hospital, New York, NY;
3
Medical Statistics, Center for Medical Statistics,
Informatics and Intelligent Systems, Medical
University of Vienna, Vienna, Austria *CR
2857 – 2878 – Tuesday – Posters
2857 — B0166 A Model of Tractional
Retinal Detachment in the Rabbit Eye. Walid
F. Abdallah1, 2, E. Barron1, G. J. Chader1, M. S.
Humayun1. 1Ophthalmology, Doheny Eye Institute,
Keck School of Medicine of the University
of Southern California, Los Angeles, CA;
2
Ophthalmology, Zagazig University, Faculty of
Medicine, Zagazig, Egypt *CR
2865 — B0174 Corneal Sensitivity and Pupil
Motility in Patients with Retinal Detachment
Treated with Vitrectomy and Circumferential
Laser Photocoagulation: Comparison Between
810 nm Diode and 523 nm Argon Lasers. Alexis
Pinel1, L. Biard2, V. Pierre-Kahn1. 1Ophthalmology,
Hôpital FOCH, Suresnes, France; 2Biostatistics,
Université Paris Descartes, Paris, France
2858 — B0167 Intraocular fluid levels of
immune mediators in retinal detachment.
Shunichiro Ueda, Y. Usui, Y. Okunuki, T. Kezuka, Y.
Wakabayashi, H. Goto. Tokyo Medical University,
Tokyo, Japan
2866 — B0175 Retinal redetachment and
post-operative days of hospitalization. Maria
L. Livani1, S. Valente2, E. Rigoni1, V. De Rosa2, G.
Rea2, E. M. Vingolo2. 1Ophthalmology, Santa Maria
Goretti Hospital, Latina, Italy; 2Ophtalmology,
University “La Sapienza”, Latina, Italy
Tuesday Posters
8:30 am – 10:15 am
2859 — B0168 The Utility Of Scleral
Depression For Detecting Peripheral
Vitreoretinal Pathology. Nikhil N. Batra1,
R. D. Patel2, S. Ittiara1, S. M. Hariprasad1.
1
Ophthalmology, University of Chicago, Chicago,
IL; 2Retinal Vitreal Consultants, Ltd., Chicago, IL
*CR
2860 — B0169 Endolaser Associated with
Cystoid Macular Edema (CME) and Epiretinal
Membrane (ERM) Formation Following Small
Gauge Retinal Detachment (RD) Repair. Tanuj
Banker1, G. Reilly2, 1, E. Weichel2, 1, K. Godfrey1.
1
Georgetown University/Washington Hospital
Center, Washington, DC; 2The Retina Group of
Washington, Washington, DC
2861 — B0170 Recovery of visual function in
macula-off rhegmatogenous retinal detachment.
Mathijs V. Put1, D. Croonen1, I. M. Nolte3, J.
M. Hooymans1, 2, L. I. Los1, 2. 1Ophthalmology,
University Medical Center Groningen, Groningen,
Netherlands; 2W.J. Kolff Institute, Graduate
School of Medical Sciences, University Medical
Center Groningen, Groningen, Netherlands; 3Unit
of Genetic Epidemiology and Bioinformatics,
Department of Epidemiology, University Medical
Center Groningen, Groningen, Netherlands f
2862 — B0171 Visual loss in retinal detachment
and macula-on after successful surgery, Retina
1 project. Jose-Carlos Pastor, I. Fernandez, M.
Castrejon, J. Rojas Spano, R. Coco, M. Sanabria,
E. Rodriguez de la Rua. IOBA-Campus Miguel
Delibes, University of Valladolid, Valladolid, Spain
*CR
2863 — B0172 Retinal blood velocity in
rhegmatogenous retinal detachment recovered
after vitrectomy but did not change after scleral
buckling procedure. Ayano Kajiyama, K. Suzuma,
H. Kinoshita, R. Ueki, T. Kitaoka. ophthalmology,
nagasaki univercity, Nagasaki, Japan
2864 — B0173 Giant Retinal Tear
Detachments: Surgical Strategies and Outcomes.
John D. Pitcher, M. A. Khan, P. P. Storey, M.
Dollin, C. D. Regillo, S. J. Garg. Retina, Wills Eye
Institute, Philadelphia, PA *CR
2867 — B0176 Use of Retained Perfluoron as
a Temporary Vitreous Substitute for Inferior
Rhegmatogenous Retinal Detachments. Gregory
Richard, B. Guidry, C. J. Chen, H. Hancock.
University of Mississippi Medical Center, Jackson,
MS
2868 — B0177 Vitrectomy with anterior
drainage without perfluorocarbon liquid for
retinal detachment repair. Christopher Rosicki, C.
S. Hwang, J. El Annan, A. D. Meleth, P. Carvounis.
Baylor College of Medicine, Houston, TX *CR
2869 — B0178 Assessing Macular Morphology
with Spectral Domain-Optical Coherence
Tomography Following Rhegmatogenous Retinal
Detachment Repair. Hemang K. Pandya, A.
Tewari, G. W. Abrams. Vitreoretinal Service, Kresge
Eye Institute, Wayne State University, Detroit, MI
2870 — B0179 Scleral buckling versus primary
vitrectomy in patients with rhegmatogenous
retinal detachment at high risk for proliferative
vitreoretinopathy. Rayan Alshareef1, 2, M.
Khuthaila1, P. P. Storey1, R. S. Kaiser1, B. Leiby1,
N. J. London1, N. Fang-Yen1. 1Retina Service, Wills
Eye Institute, Philadelphia, PA; 2Ophthalmology,
McGill University, Montreal, QC, Canada *CR
2874 — B0183 Incidence of tears and retinal
detachments after macular surgery according
to the depression of the vitrectomy cutter.
Jérôme Selton, I. Hubert, J. Berrod. Chu Nancy,
Vandoeuvre les Nancy, France
2875 — B0184 Small gauge direct silicon oil
(SO) perfluoro-n-octane (PFO) interchange.
Comparison of two methods: use of chandelier
light (CHL) and use of viscous fluid infusion
cannula(VFIC). Hugo Quiroz-Mercado1, 2, R.
Bhandari2, 1, S. Schwartz1, 2, J. Olson2, S. Oliver2,
N. Mandava2, R. Velez-Montoya2, M. Mathias1, 2.
1
Ophthalmology, Denver Health Medical
Center. University of Colorado, Denver, CO;
2
Ophthalmology, Rocky Mountain Lions Eye
Institute. University of Colorado, Denver, CO *CR
2876 — B0185 Minimal invasive scleral
buckling surgery without limbal peritomy
for uncomplicated primary rhegmatogenous
retinal detachment. Peiquan Zhao, H. Jin, Q.
Zhang. Ophthalmology, Xinhua Hospital Jiaotong
University, Shanghai, China
2877 — B0186 Same day versus next day repair
of fovea threatening primary rhegmatogenous
retinal detachments. Ian Gorovoy, T. Porco, J. M.
Stewart. Ophthalmology, UCSF, San Francisco, CA
*CR
2878 — B0187 Relationship between
axial length and retinal tear location in the
rhegmatogenous retinal detachment surgery.
Young Ju Lew1, J. Baek1, Y. Kim2, J. Han1, E.
Chung3, T. Lee1. 1Ophthalmology, Kim’s Eye
Hospital, Seoul, Republic of Korea; 2Preventive
medicine, Dong-A university, Busan, Republic of
Korea; 3Ophthalmology, National Health Insurance
Corporation Ilsan Hospital, Gyounggi-do, Republic
of Korea
2871 — B0180 Inhibition of autophagy by 3MA
enhances the effect of ERS-mediated apoptosis
in photoreceptors after experimental retinal
detachment. Hong Zhu1, 2, F. Wang1, X. Sun1.
1
Department of Ophthalmology, Shanghai First
People’s Hospital, School of Medicine, Shanghai
JiaoTong University, Shanghai, China; 2Wellman
Center for Photomedicine, Massachusetts General
Hospital, Harvard Medical School, Boston, MA
2872 — B0181 Morphologic changes after
retinal detachment surgery using spectral
domain optical coherence tomography.
Soldermann Yoann, B. Ygal, C. Pierre Loic, B.
Sylvain, B. Carole. ophtalmology, hôpital edouard
herriot, Lyon, France
2873 — B0182 Vitreoretinal Surgery With
Silicone Oil Injection in Uncomplicated
Rhegmatogenous Retinal Detachment: Clinical
and Intra-Ocluar Pressure Outcomes. George
Azar1, 2, E. Jabbour1, J. Antoun1, A. Jalkh1, 2.
1
Ophthalmology, Eye & Ear University Hospital,
Beirut, Lebanon; 2Department of Medicine,
Université Saint Esprit Kaslik (USEK), Beirut,
Lebanon
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
204
Tuesday – Posters – 2879 – 2894
Exhibit Hall B0248-B0295
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Immunology/Microbiology / Clinical/
Epidemiologic Research
316 Clinical and Translational Studies
in Ocular Infection and Immunity
Moderators: Mary E. Marquart and
Manabu Mochizuki
2880 — B0249 Longitudinal Cytokine Analysis
of Aqueous Humor in CMV Retinitis - The CMV
Retinitis Intravitreal Ganciclovir Singapore
Study (CRIGSS). Jayant V. Iyer1, 3, B. Au2, S.
Tang2, J. E. Connolly2, R. V. Agrawal1, T. Yeo1, S. C.
Teoh2. 1Ophthalmology, National Healthcare Group,
Tan Tock Seng Hospital, Singapore, Singapore;
2
Singapore Immunology Network, Singapore,
Singapore; 3Ophthalmology, Singapore National
Eye Centre, Singapore, Singapore f
2881 — B0250 Spectral Domain-Optical
Coherence Tomography Findings in Acute
Syphilitic Posterior Placoid Chorioretinopathy.
Antonio P. Ciardella1, F. Pichi2, E. T.
Cunningham3 4, J. Jumper5, J. L. Davis6, T. A.
Albini6, D. Sarraf7, E. Bertelli8, M. Morara1, P.
Nucci2. 1Ophthalmology, Policlinico S Orsola
Malpighi, Bologna, Italy; 2San Giuseppe Hospital,
University Eye Clinic, Milan, Italy; 3Department of
Ophthalmology, California Pacific Medical Center,
San Francisco, CA; 4Department of Ophthalmology,
Stanford University School of Medicine, Stanford,
CA; 5West Coast Retina Medical Group, California
Pacific Medical Center, San Francisco, CA;
6
Bascom Palmer Eye Institute, University of MiamiMiller School of Medicine, Miami, FL; 7Jules Stein
Eye Institute, UCLA, Los Angeles, CA; 8Bolzano
Central Hospital, Department of Ophthalmology,
Bolzano, Italy *CR
2883 — B0252 Utility of Lyme Antibody
Testing in the Uveitis Workup. Lana M. Rifkin, A.
D. Birnbaum, A. S. Parekh, C. Jumroendararasame,
D. Pyatetsky, D. A. Goldstein. Ophthalmology,
Northwestern University, Chicago, IL *CR
2884 — B0253 A Comparison of the Etiology
of Infectious Corneal Ulcers and Bacterial
Susceptibility to Antibiotics in Non-Contact Lens
and Contact Lens Wearers at the University of
Chicago. Krishna Patel1, M. A. Saidel2. 1University
of Missouri Kansas City, Kansas City, MO;
2
University of Chicago, Chicago, IL *CR
2885 — B0254 Association of Type III
Secretion System, Serotype, and Antibiotic
Susceptibility of P. aeruginosa from Ocular
Isolates. Elizabeth Shen1, 2, F. Hu2. 1Department
of Ophthalmology, Buddhist Tzu Chi General
Hospital Taipei Branch, Xindian, Taipei, Taiwan;
2
Department of Ophthalmolgy, National Taiwan
University Hospital, Taipei, Taiwan
2886 — B0255 Prevalence and characteristics
of MRSA from clinical conjunctivitis trials
versus ocular surveillance studies. Timothy
W. Morris, C. M. Sanfilippo, C. K. Hesje, M.
E. MacGilvray, W. Haas. Bausch & Lomb, Inc,
Rochester, NY *CR
2887 — B0256 Detection of Organisms by
Microbiology vs. Histopathology in Corneal
Biopsy and Penetrating Keratoplasty Specimens.
Sander R. Dubovy, N. Buchser, G. Amescua, D.
Miller. Bascom Palmer Eye Institute, University of
Miami, Miami, FL
2888 — B0257 The Effects of Using Steroid or
Combination Antibiotic/Steroid Drops on Ocular
Culture Results. Peter Belin1, 2, D. Miller2, A. E.
Kuriyan2, H. W. Flynn2. 1Herbert Wertheim College
of Medicine, Florida International University,
Miami, FL; 2Bascom Palmer Eye Institute,
University of Miami Miller School of Medicine,
Miami, FL
2889 — B0258 Interleukin-6 Gene
Polymorphisms in Patients with Keratitis.
Venkata Nagaraju Konda1, 2, M. D. Willcox2,
I. Kaur3, P. M. Sudharaman4, P. Garg4, S.
Chakrabarti3. 1Brien Holden Vision Institute,
University of New South Wales, Sydney, NSW,
Australia; 2Optometry and Vision Science, UNSW,
New south wales, NSW, Australia; 33Kallam Anji
Reddy Molecular Genetics Laboratory, L. V. Prasad
Eye Institute, Hyderabad, India; 4Department of
Cornea, L. V. Prasad Eye Institute, Hyderabad,
India *CR
2890 — B0259 Demographics and Bacterial
Contamination Influences in Antibacterial
Effectiveness of Human Milk. Justin Baynham1,
A. Moorman2, C. Donnellan3, V. Cevallos3, J.
D. Keenan1, 3. 1Ophthalmology, University of
California, San Francisco, San Francisco, CA;
2
Pediatrics, University of California, San Francisco,
San Francisco, CA; 3Francis I. Proctor Foundation
for Research in Ophthalmology, San Francisco, CA
2891 — B0260 Keratitis-induced changes to the
homeostatic microbiome at the human cornea.
Alexander I. Tuzhikov1, Q. Dong2, A. Y. Panchin3,
O. Thanathanee4, N. M. Shalabi1, D. Nelson5, L.
Akileswaran6, R. N. Van Gelder6, T. P. O’Brien1, V.
I. Shestopalov1, 7. 1Department of Ophthalmology,
Bascom Palmer Eye Institute, University of Miami,
School of Medicine, Miami, FL; 2Departments
of Biological Sciences, Computer Science and
Engineering, University of North Texas, Texas, TX;
3
Belozersky Institute of Physico-Chemical Biology,
Lomonosov Moscow State University, Moscow,
Russian Federation; 4Department of Ophthalmology,
Srinagarind Hospital Khon Kaen University, Khon
Kaen, Thailand; 5Department of Biology, Indiana
University, Bloomington, IN; 6Department of
Ophthalmology, University of Washington, Seattle,
WA; 7Vavilov Institute of General Genetics, Vavilov
Institute of General Genetics, Moscow, Russian
Federation *CR
2892 — B0261 Stratification of antigenpresenting cells within the normal human
cornea. Jared E. Knickelbein, K. Buela, R.
L. Hendricks. Ophthalmology, University of
Pittsburgh, Pittsburgh, PA
2893 — B0262 Human tear fluid triggers
virulence expression by Pseudomonas aeruginosa
biofilms growing on soft contact lenses. Yvonne
Wu1, C. Tam1, D. J. Evans1, 2, S. M. Fleiszig1.
1
School of Optometry and Vision Science,
University of California, Berkeley, Berkeley, CA;
2
Touro University, College of Pharmacy, Vallejo,
CA *CR
2894 — B0263 Efficacy of photodynamic
antimicrobial chemotherapy on gram negative
bacteria. Taiichiro Chikama1, M. Latief1, M.
N. Shibasaki1, J. Ko1, T. Sasaki1, Y. Kiuchi1, T.
Sakaguchi2, A. Obana3. 1Ophthalmology, Hiroshima
Univ Grad Sch of Biomed Sci, Hiroshima, Japan;
2
Virology, Hiroshima Univ Grad Sch of Biomed
Sci, Hiroshima, Japan; 3Ophthalmology, Seirei
Hamamatsu General Hospital, Hamamatsu, Japan
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
205
Tuesday Posters
8:30 am – 10:15 am
2879 — B0248 A High Speed Detection
Platform Based on Surface-Enhanced Raman
Scattering for Rapid Diagnosis of Bacterial
Endophthalmitis. Ching-Ju Hsieh1, 2, F. Hu3,
D. Wang4, J. Wang4, 5, Y. Wang5, 6, C. Lin2, 7.
1
Ophthalmology, Taipei City Hospital, Taipei,
Taiwan; 2Institute of Biophotonics, National Yang
Ming University, Taipei, Taiwan; 3Ophthalmology,
National Taiwan University Hospital, Taipei,
Taiwan; 4Institute of Atomic and Molecular
Sciences, Academic Sinica, Taipei, Taiwan; 5Center
for Condensed Matter Sciences, National Taiwan
University, Taipei, Taiwan; 6Physics, National
Taiwan University, Taipei, Taiwan; 7Institute of
Microbiology and Immunology, School of Life
Science, National Yang-Ming University, Taipei,
Taiwan
2882 — B0251 Ocular syphilis: case series
(2000-2009) from two tertiary care centers
in Montreal. Kinda Najem1, 2, L. Jaworski3, A.
Labbé4, 1, C. Fortin5, 1, . Fortin6, 1, M. Bélair6, 1,
B. Serhir7, M. Aubin6, 1. 1University of Montreal,
Montreal, QC, Canada; 2Ophthalmology, Notre
Dame Hospital, CHUM, Montreal, QC, Canada;
3
Ophthalmology, Sacré-Coeur Hospital, Montreal,
QC, Canada; 4Microbiology, MaisonneuveRosemont Hospital, Montreal, QC, Canada;
5
Microbiology, Notre Dame Hospital, CHUM,
Montreal, QC, Canada; 6Ophthalmology,
Maisonneuve-Rosemont Hospital, Montreal, QC,
Canada; 7Laboratoire de santé publique du Québec,
Sainte-Anne-de-Bellevue, QC, Canada *CR
2895 – 2917 – Tuesday – Posters
2895 — B0264 Increasing coverage of a vaccine
against herpes zoster at New York University
Langone Medical Center and Bellevue Hospital.
Ilyse D. Haberman1, E. J. Cohen1, Z. Elkin4, J.
D. Goldberg2, X. Li2, E. Castano1, L. Park1, M.
H. Perskin3. 1Department of Ophthalmology,
New York University School of Medicine, New
York, NY; 2Division of Biostatistics, New York
University School of Medicine, New York, NY;
3
Division of General Internal Medicine, Department
of Medicine, New York University School of
Medicine, New York, NY; 4New York University
School of Medicine, New York, NY *CR, f
Tuesday Posters
8:30 am – 10:15 am
2896 — B0265 Rare and newer Non
Sporulating Moulds emerging as corneal
pathogens identified by molecular techniques
in a Tertiary Eye Care Centre. Gayathri
Ramasubban, L. Therese, B. Radhakrishnan, H. N.
Madhavan. L&T Microbiology Research Centre,
Vision Research Foundation, Chennai, India
2897 — B0266 Efficacy and Safety of
Voriconazole and Amphotericin B as Additives
in Optisol-GS Corneal Storage Media Against
Candida Species. Noelle Layer1, V. Cevallos2, A.
J. Maxwell3, C. Ulrickson3, J. D. Keenan1, 2, B. H.
Jeng1, 2. 1Ophthalmology, University of California,
San Francisco, San Francisco, CA; 2Francis I.
Proctor Foundation, San Francisco, CA; 3SightLife,
Seattle, WA
2898 — B0267 Rapid and sensitive diagnosis
of Acanthamoeba keratitis by loop-mediated
isothermal amplification. Ge Zhao, Q. Yuan.
Shandong Eye Institution, Qingdao, China
2899 — B0268 Topical Linezolid 0.2% for the
Treatment of Gram Positive Bacterial Keratitis.
Elmer Y. Tu, S. Jain. Ophthalmology, University of
Illinois at Chicago, Glenview, IL *CR
2903 — B0272 Antibiotic resistance and
molecular characterization of ocular isolates of
Acinetobacter baumanniii. Deepa Talreja1, 2, C.
Muraleedharan2, K. Kaye3, S. K. Walia2, A. Kumar1,
4 1
. Ophthalmology, Kresge Eye Institute, Detroit,
MI; 2Biological Sciences, Oakland University,
Auburn Hills, MI; 3Internal Medicine, Detroit
Medical Centre Wayne state University, Detroit,
MI; 4Anatomy and Cell Biology, Wayne State
University, Detroit, MI *CR
2904 — B0273 Antibiotic Resistance
Surveillance of Ocular Pathogens - four years
of ARMOR Study Results. Wolfgang Haas1, J.
Deane2, T. W. Morris1, D. F. Sahm2. 1Microbiology
and Sterilization Sciences, Bausch & Lomb, Inc,
Rochester, NY; 2Eurofins Medinet, Inc., Chantilly,
NY *CR
2905 — B0274 Case Control Study of Herpes
Zoster Ophthalmicus in the Bronx Using
Population-based and Clinic-based Controls.
David M. Poulsen1, 2, G. Honik1, 2, D. C. Gritz1, 2.
1
Ophthalmology and Visual Sciences, Albert
Einstein College of Medicine, Bronx, NY;
2
Ophthalmology and Visual Sciences, Montefiore
Medical Center, Bronx, NY
2906 — B0275 Clinical and Microbiological
profile of Paediatric Keratitis in a tertiary care
hospital in Hong Kong. Vishal Jhanji1, 2, A. L.
Young2, K. S. Leung2, N. Tsim2, M. Hui3, L. Cheng2.
1
Ophthalmology and Visual Sciences, The Chinese
University of Hong Kong, Hong Kong, Hong Kong;
2
Ophthalmology and Visual Sciences, Prince of
Wales Hospital, Shatin, Hong Kong, Hong Kong;
3
Microbiology, The Chinese University of Hong
Kong, Hong Kong, Hong Kong
2907 — B0276 Assessment of Risk Factors for
Oxacillin-Resistant Ocular Flora from Patients
Undergoing Cataract Surgery. Hugo Y. Hsu1,
J. T. Lind2, D. Miller3. 1Ophthalmology, Doheny
Eye Institute, Los Angeles, CA; 2Ophthalmology,
Saint Louis University, Saint Louis, MO;
3
Ophthalmology, Bascom Palmer Eye Institute,
Miami, FL *CR
2900 — B0269 Predictors of outcome in
fungal keratitis using data from the Mycotic
Ulcer Treatment Trial I. Catherine Q. Sun1, N. V.
Prajna4, T. Krishnan5, M. Srinivasan4, K. J. Ray1,
S. D. McLeod1, 2, T. Porco1, 3, N. Acharya1, 2, T. M.
Lietman1, 2. 1F.I. Proctor Foundation, University
of California San Francisco, San Francisco, CA;
2
Department of Ophthalmology, University of
California San Francisco, San Francisco, CA;
3
Department of Epidemiology and Biostatistics,
University of California San Francisco, San
Francisco, CA; 4Cornea, Aravind Eye Care System,
Madurai, India; 5Cornea, Aravind Eye Care System,
Pondicherry, India *CR, f
2908 — B0277 Clinical and Pathologic Findings
in Patients with Suspected Infectious Keratitis:
A Single Institution Experience. Yousef J. CruzInigo1, 2, S. V. Patel2, L. Maguire2, J. J. Garcia1,
D. R. Salomao1, 2. 1Department of Laboratory
Medicine and Pathology, Mayo Clinic, Rochester,
MN; 2Department of Ophthalmology, Mayo Clinic,
Rochester, MN
2901 — B0270 Acanthamoeba Keratitis - a
clinical outcome. Mark Saeger, A. Saeger, K.
Purtskhvanidze, S. O. Koinzer, J. Roider, B. Noelle.
Department of Ophthalmology, University of Kiel,
Kiel, Germany *CR
2909 — B0278 Clinical features of anterior
uveitis caused by three different types of herpes
virus. Jun Suzuki, J. Sakai, Y. Usui, T. Kezuka, H.
Goto. Ophthalmology, Tokyo Medical University
Hospital, Tokyo, Japan
2902 — B0271 Microstructural analysis of
radial keratoneruitis in patients with early stage
Acanthamoeba keratitis using in vivo confocal
microscopy. Natsuko Yamazaki, A. Kobayashi, H.
Yokogawa, K. Sugiyama. Kanazawa Univ Grad
School of Med Sci, Kanazawa, Japan
2910 — B0279 Comparative efficacy of two
different regimens of povidone-iodine 5% eye
drops instillation in reducing conjunctival
bacterial flora - a preliminary report. Leticia
F. Barroso, A. Nepomuceno, S. P. Cazella, J.
A. Ribeiro, L. Castilho, A. Messias, R. Jorge.
Ophthalmology, School of Medicine of Ribeirao
Preto, University of São Paulo, Ribeirao Preto,
Brazil f
2911 — B0280 Ocular straylight and contrast
sensitivity in HIV-positive patients compared
with normal subjects. Nazli Demirkaya1, T. J. Van
Den Berg3, S. Darma1, R. O. Schlingemann1, F. D.
Verbraak1, 2. 1Ophthalmology, Academic Medical
Center Amsterdam, Amsterdam, Netherlands;
2
Biomedical Engineering and Physics, Academic
Medical Center Amsterdam, Amsterdam,
Netherlands; 3Ocular Signal Transduction,
Netherlands Institute for Neuroscience, Amsterdam,
Netherlands *CR
2912 — B0281 Ocular manifestations of
Granulomatosis with Polyangiitis from
the “Institute of Ophthalmology Conde de
Valenciana”. Miguel Pedroza-Seres, E. J. Robles,
D. A. González. Dept of Uveitis & Ocular Immunol,
Institute of Ophthalmology, Mexico City, Mexico
2913 — B0282 Molecular Quantification of
Herpes Simplex Virus (HSV) by Real-Time
PCR in Tear Film and Correlation with Human
Disease. Nora L. Cothran1, K. Ramirez2, 3, R.
Thompson5, A. Patel5, D. G. Fuller1, J. DeVincenzo3,
4 1
. Southern College of Optometry, Memphis, TN;
2
Infectious Disease, St. Jude Children’s Research
Hospital, Memphis, TN; 3Pediatrics, University of
Tennessee Center for Health Sciences, Memphis,
TN; 4Microbiology, Immunology and Biochemistry,
University of Tennessee Center for Health Sciences,
Memphis, TN; 5Children’s Foundation Research
Institute at Le Bonheur Children’s Hospital,
Memphis, TN *CR
2914 — B0283 Effective treatment of Herpes
Zoster Ophthalmicus Acute with a single
injection preauricular. Eduardo Arenas, F. Alvizu.
Dept 0630, Santa Fe Foundation, Miami, FL
2915 — B0284 Yield of Ophthalmology
Consults in Fungemic Patients in a Tertiary Care
Hospital Setting. Ankoor R. Shah, D. Ghodasra,
B. VanderBeek. Ophthalmology, University of
Pennsylvania Scheie Eye Institute, Philadelphia, PA
2916 — B0285 Interferon Alpha in the
Treatment of Chronic Cystoid Macular Edema
Following Cataract Surgery (Irvine-Gass
Syndrome). Christoph M. Deuter, F. Gelisken, M.
Zierhut, D. Doycheva. Centre for Ophthalmology,
University of Tuebingen, Tuebingen, Germany *CR
2917 — B0286 Monitoring necrotizing viral
retinitis by gene amplification of ocular fluids.
Anne Sikorav1, P. Le Hoang1, F. Rozenberg2, B.
Bodaghi1. 1ophtalmology, La Pitie Salpetrière
Hospital, Paris, France; 2Virology, Cochin Hospital,
Paris, France *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
206
Tuesday – Posters – 2918 – 2938
2918 — B0287 Yellowish dots in the retina: a
new finding of ocular syphilis? Renan Rodrigues,
G. Salomao, H. Nascimento, C. Muccioli.
Ophthalmology, Federal University of Sao Paulo,
Sao Paulo, Brazil
2919 — B0288 Demographics and Clinical
Characteristics of Patients Presenting with
Ocular Manifestations of Systemic Syphilis.
Archana T. Seethala, N. H. Siegel, S. D. Ness, D.
Husain. Ophthalmology, Boston University Medical
Center, Boston, MA
2920 — B0289 THe Efficacy and Outcomes
of combination Intravitreal Foscarnet and
Ganciclovir in Herpetic Retinitis. Rajiv E. Shah,
S. J. Garg. Ophthalmology, Wills Eye Institute,
Philadelphia, PA *CR
2921 — B0290 Novel Minimum Inhibitory
Concentration (MIC) Assay to Measure the
Effectiveness of Antimicrobial Treatments
Against Acanthamoeba Trophozoites and Cysts.
Christopher Kovacs, S. C. Lynch, J. G. Carr, C. M.
Sanfilippo, W. Haas, J. Kilbury, K. A. Millard, T. W.
Morris. Bausch & Lomb, Inc., Rochester, NY *CR
2923 — B0292 The Preventive Effect
by the Drug Released Soft Contact Lens
against Bacterial Endophthalmitis. Shinichiro
Kobayakawa1, T. Matsunaga2. 11st Dept of
Ophthalmology, Toho University, Tokyo, Japan;
2
Seed Co., Ltd., Kounosu, Japan *CR
2924 — B0293 Culture and Reverse
Transcriptase Polymerase Chain Reaction (RTPCR) proven Tuberculous Endophthalmitis
- First report from a Tertiary Eye Centre. Ekta
Rishi1, L. Therese2, V. R. Sharma1, R. Gayathri2,
L. Dhanurekha2, P. Rishi1, H. N. Madhavan2. 1Shri
Bhagwan Mahavir Vitreoretinal Services, Sankara
Nathralya, Chennai, India; 2L & T Microbiology
Research Centre, Sankara Nathralya, Chennai, India
2925 — B0294 Rate of endophthalmitis
following elective cataract surgery. Amos
Aranowicz1, K. U. Kortuem1, M. M. Nentwich1,
Y. Yactayo Miranda1, A. Kampik1, H. Mino de
Kaspar1, 2. 1Ophthalmology, Ludwig-MaximiliansUniversity, Munich, Germany; 2Department of
Ophthalmology, Stanford University, Stanford, CA
2926 — B0295 Prevalence of Staphylococcal
Cassette Chromosome Mec (SCCmec Cassette)
Types and Panton-Valentine Leukocidin (PVL)
Toxin Among Staphylococcus aureus Vitreus and
Anterior Chamber Isolates. Noy Ashkenazy1, J.
Maestre2, A. M. Abbey2, 1, D. Miller2, H. W. Flynn2, 1.
1
University of Miami Miller School of Medicine,
Miami, FL; 2Bascom Palmer Eye Institue, Miami,
FL
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Immunology/Microbiology / Retina
317 Posterior Segment Inflammation I
Moderator: Masaru Takeuchi
2927 — B0296 Evaluation of Suprachoroidal
Microinjection of Triamcinolone Acetonide
in a Model of Panuveitis in Albino Rabbits.
Samirkumar R. Patel1, R. Carvalho2, K. E.
Mundwiler2, C. Meschter3, R. S. Verhoeven1.
1
Clearside Biomedical, Atlanta, GA; 2Biological
Testing Center, Irvine, CA; 3Comparative
Biosciences, Sunnyvale, CA *CR
2928 — B0297 Beta-glucogallin Suppresses
Lipopolysaccharide-induced Inflammatory
Markers by Aldose Reductase Inhibition in
Murine Macrophages and Ocular Tissues. KunChe Chang1, 2, B. Laffin1, J. Ponder2, A. Enzsoly3,
J. Nemeth3, D. V. LaBarbera2, J. M. Petrash1, 2.
1
Ophthalmology, University of Colorado, Aurora,
CO; 2Pharmaceutical Sciences, University
of Colorado, Aurora, CO; 3Ophthalmology,
Semmelweiss University, Budapest, Hungary *CR
2929 — B0298 Investigation of the role of CD70
in the development of experimental autoimmune
uveitis in mice. Yoko Okunuki1, Y. Usui1, R.
Matsuda1, F. Kamachi2, A. Umazume1, S. Ueda1,
T. Kezuka1, H. Akiba2, H. Goto1. 1Ophthalmology,
Tokyo Medical Univ Hospital, Tokyo, Japan;
2
Immunology, Juntendo University School of
Medicine, Tokyo, Japan
2930 — B0299 Angiotensin-Converting
Enzyme 2 (ACE2) Activator DIZE Ameliorates
Endotoxin-Induced Uveitis in Mice. Yiguo
Qiu1, 2, P. K. Shil1, P. Zhu1, H. Yang2, B. Lei2, Q.
Li1. 1Department of Ophthalmology, University
of Florida, Gainesville, FL; 2Department of
Ophthalmology, The First Affiliated Hospital of
Chongqing Medical University, Chongqing Key
Laboratory of Ophthalmology, Chongqing Eye
Institute, Chongqing, China
2933 — B0302 Intravitreal dexamethasone
implant for the treatment of persistent Uveitic
Macular Edema. Alfredo Adan Civera1, V.
Llorens1, M. Mesquida1, B. Molins2, A. de Rocha
Cardoso4, M. R. Santos de Almeida3, L. Pelegrin1.
1
Ophthalmology, Hospital Clinic, Barcelona,
Spain; 2Ophthalmology, Fundació Clinic
Recerca Biomèdica,IDIBAPS, Barcelona, Spain;
3
Ophthalmology, Centro Hospitalar e Universitário
de Coimbra, Coimbra, Portugal; 4Ophthalmology,
Centro Hospitalar Leiria, Pombal, Portugal
2934 — B0303 Long-term results of
fluocinolone acetonide intravitreal implant in
Behcet’s patients with intractable posterior
uveitis. Eun Kyu Oh1, H. Yu1, 2. 1Department of
Ophthalmology, Seoul National University College
of Medicine, Seoul, Republic of Korea; 2Medical
Research Center, Seoul National University, Seoul,
Republic of Korea
2935 — B0304 Long-term results of
Intravitreal Bevacizumab for the Treatment of
Choroidal Neovascular Membranes associated
with Presumed Ocular Histoplasmosis
Syndrome. Sarah Escott, S. Chang, A. Tarabishy,
M. Barsamian, J. B. Christoforidis, F. Davidorf, A.
Letson. Ophthalmology, The Ohio State University
Wexner Medical Center, Columbus, OH *CR
2936 — B0305 Trimethoprim-sulfamethoxazole
versus placebo to reduce the risk of recurrences of
Toxoplasma gondii retinochoroiditis: randomized
controlled clinical trial (ISROT). Joao P. Felix,
R. S. Zacchia, J. M. Toribio, M. A. Nascimento,
C. E. Arieta, H. Panetta, V. Balarin, R. P. Lira.
Oftalmologia, Unicamp, Campinas, Brazil f
2937 — B0306 The Effect of Subsets
of Monocytes on T cell activation and its
implication in uveitis. Zhiyu Li, B. Liu, M. Casady,
J. Dailey, S. Hirani, S. Jawad, R. Katamay, H. Sen,
R. B. Nussenblatt. NIH, Bethesda, MD
2938 — B0307 Efficacy and safety of systemic
infliximab for uveitis in Behçet’s disease. Aya
Tobe, T. Oshitari, S. Yamamoto. Chiba University,
Chiba, Japan
2931 — B0300 Adulthood Uveitis Epidemiology
at a Single Spanish Tertiary Referral Centre.
Victor Llorens1, M. Mesquida1, L. Pelegrin1,
B. Molins2, A. Adan Civera1. 1Institut Clínic
d’Oftalmologia (ICOF), Hospital Clínic de
Barcelona, Barcelona, Spain; 2Institut de Recerca
Biomèdica August Pi i Sunyer (IDIBAPS), Hospital
Clínic de Barcelona, Barcelona, Spain
2932 — B0301 A national survey of Canadian
ophthalmologists’ knowledge and application of
uveitis management guidelines. Crystal Cheung1, 2,
N. Noordeh2, C. Gottlieb2. 1Faculty of Medicine,
University of Ottawa, Ottawa, ON, Canada;
2
Ophthalmology, University of Ottawa Eye Institute,
Ottawa, ON, Canada *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
207
Tuesday Posters
8:30 am – 10:15 am
2922 — B0291 Phylogenetic study of
Acanthamoeba genotypes determined by 18S
rDNA gene analysis. Denise Freitas, F. Marques
de Carvalho Taguchi, L. C. Carrijo-Carvalho, V.
Peracini, A. Foronda, F. Ramos. Ophthalmology,
Federal University of Sao Paulo, Sao Paulo, Brazil
Exhibit Hall B0296-B0317
Tuesday Posters
8:30 am – 10:15 am
2939 – 2957 – Tuesday – Posters
2939 — B0308 The Prevalence, Incidence and
Risk Factors for Exudative Retinal Detachment
in Uveitis. Deepika Shah1, C. Newcomb3, G. LevyClarke5, R. B. Nussenblatt5, J. T. Rosenbaum6, 7,
E. B. Suhler6, 8, J. E. Thorne9, 10, C. Foster4, 11, D.
A. Jabs12, 13, J. H. Kempen1, 2. 1Ophthalmology,
Scheie Eye Institute, University of Pennsylvania,
Philadelphia, PA; 2Center for Preventive
Ophthalmology and Biostatistics, Department
of Ophthalmology, University of Pennsylvania,
Philadelphia, PA; 3Center for Clinical Epidemiology
and Biostatistics, Department of Biostatistics
and Epidemiology, University of Pennsylvania,
Philadelphia, PA; 4Ophthalmology, Massachusetts
Eye Research and Surgery Institution, Cambridge,
MA; 5National Eye Institute, Laboratory of
Immunology, National Institutes of Health,
Bethesda, MD; 6Ophthalmology, National Institutes
of Health, Bethesda, MD; 7Medicine, Oregon
Health and Science University, Portland, OR;
8
Ophthalmology, Portland Veteran’s Affairs Medical
Center8, Portland, OR; 9Ophthalmology, The Johns
Hopkins University, Bethesda, MD; 10Epidemiology,
The Johns Hopkins University, Bethesda, MD;
11
Ophthalmology, Masachussets Eye and Ear
Infirmary, Harvard Medical School, New York, NY;
12
Medicine, Mount Sinai School of Medicine, New
York, NY; 13Ophthalmology, Mount Sinai School of
Medicine, New York, NY *CR
2940 — B0309 Imaging of paravascular
infiltrates and epiretinal proliferation in
posterior uveitis using adaptive optics. Michel
Paques, M. Errera. Clinical Investigation Center
503, Quinze-Vingts Hospital, INSERM, Paris,
France *CR, f
2941 — B0310 OCT characteristics of patients
with uveitis with epiretinal membranes, cystoid
macular edema, or both. Ghazala A. Datoo
O’Keefe1, H. Nazari Khanamiri1, 2, N. A. Rao1.
1
Ophthalmology, USC Doheny Eye Institute, Los
Angeles, CA; 2Department of Ophthalmology,
Rassoul Akram Hospital, Tehran University of
Medical Sciences, Tehran, Islamic Republic of Iran
2942 — B0311 Association between choroidal
thickness and activity of ocular inflammation
in Behçet’s disease. Sho Ishikawa, M. Taguchi,
T. Muraoka, M. Takeuchi. Opthalmology, Nat’l
Defense Med College, Tokorozawa, Japan
2943 — B0312 Microperimetric Assessment
of Macular Changes in Vogt-KoyanagiHarada Disease. Xiu-Ling Tan, S. C. Teoh, S.
Ho. Ophthalmology, National Healthcare Group
Institute, Tan Tock Seng Hospital, Singapore,
Singapore, Singapore
2944 — B0313 Demographics and Clinical
Features in Serpiginous Choroidopathy
and Acute Multifocal Placoid Pigmented
Epitheliopathy (AMPPE). Ester Carreno1, D. A.
Sim2, 1, P. A. Keane1, 2, J. Zarranz-Ventura3, 2, G.
Fernandez Sanz1, D. Thomas1, M. C. Westcott1, A.
Tufail1, C. E. Pavesio1. 1Medical Retina, Moorfields
Eye Hospital, London, United Kingdom; 2National
Institute for Health Research (NIHR) Biomedical
Research Centre at Moorfields Eye Hospital
NHS Foundation Trust and UCL Institute of
Ophthalmology, London, United Kingdom; 3VitreoRetinal Service, Gloucestershire NHS Foundation
Trust, Cheltenham, United Kingdom *CR
2945 — B0314 Masquerade Syndromes.
Amr Kouchouk1, 2, M. D. Dalal2, H. Sen2, 1, R.
B. Nussenblatt2, L. Grange2, M. Rostamizadeh2.
1
George Washington University, Arlington, VA;
2
National Eye Institute, Bethesda, MD
2946 — B0315 Spontaneous Dislocation of
the Pellet from the Strut in the Fluocinolone
Acetonide Sustained Release Implant
(Retisert®). Sujit Itty, J. Martel, G. J. Jaffe. Dept
of Ophthalmology, Duke Eye Center, Durham, NC
*CR
2947 — B0316 Effect of Treatment Modality
on Quality of Life in Patients with NonInfectious Uveitis. Wei Gui1, M. Dombrow2, I.
Marcus4, B. Tessier-Sherman3, M. H. Stowe3, J.
Huang1. 1Ophthalmology and Visual Science, Yale
University, New Haven, CT; 2School of Medicine,
Yale University, New Haven, CT; 3Occupational
and Environmental Medicine Program, Yale
University, New Haven, CT; 4Duke Eye Center,
Duke University, Durham, NC
2948 — B0317 Detection of Progression of
Visual Field Loss in Serial Humphrey Visual
Fields in Birdshot Chorioretinopathy by
Pointwise Linear Regression Analysis. Bharti
Arya1, M. C. Westcott1, C. E. Pavesio1, 2. 1Medical
Retina and Uveitis, Moorfields Eye Hosp NHS
Fndtn Trust, London, United Kingdom; 2NIHR
Biomedical Research Centre for Ophthalmology,
London, United Kingdom
Exhibit Hall C0040-C0073
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Lens
318 Cataractogenesis
Moderators: J S. Zigler and Paul G. FitzGerald
2949 — C0040 Posterior capsular plaques
express cell junction proteins implying their
epithelial origin and involvement of MAPK/
ERK pathway in modulating cell junction
proteins. Anshul I. Arora, A. R. Patel, K. Johar,
D. A. Ganatra, F. B. Kayastha, D. U. Gajjar, A.
R. Vasavada. Cell and Molecular biology, Iladevi
Cataract and IOL Research Centre, Ahmedabad,
India
2950 — C0041 EGFR-Blockade With Erlotinib
Influences FGF, EGF, TGF-β2 And EGFR
Expression and causes Changes In ActinCytoskeleton which might influence Different
Aspects Of Cellular Migration In A Time Lapse
Microscopy Analysis of Human Lens Epithelial
Cells. Christian M. Wertheimer1, R. Liegl1, M.
Kernt1, D. Docheva2, A. Kampik1, K. Eibl-Lindner1.
1
Munich University Eye Hospital, LMU, Munich,
Germany; 2Munich Department of Surgery, LMU,
Munich, Germany *CR
2951 — C0042 Co-culture with materialactivated macrophages induce an inflammatory
phenotype in lens epithelial cells. Rob Pintwala,
C. K. Postnikoff, M. Gorbet. Systems Design
Engineering, University of Waterloo, Waterloo, ON,
Canada *CR
2952 — C0043 Ultrastructural
Changes in Regenerated Tissue Around a
Polyvinylpyrrolidone Hydrogel Accommodative
Intraocular Lens during Long-term
Observation. Kyoko Miura1, Y. Shinohara2, S.
Yokota1, S. Nagasaka1, M. Nakatani2, T. Sunada1.
1
Product Development, IOL Development
Dept., R&D Div., Medical & Optical Operations
Headquarters, NIDEK Co., Ltd., Gamagori, Japan;
2
Bioengineering Institute, NIDEK Co., Ltd.,
Gamagori, Japan *CR
2953 — C0044 Histone Deacetylase Inhibitors
Trichostatin A and Vorinostat Inhibit TGF-β2
-Induced Epithelial to Mesenchymal Cell
Transition of Lens Epithelium. K Krishna
Sharma, L. Xie, P. Santhoshkumar, L. W. Reneker.
Ophthalmology and Biochemistry, University of
Missouri, Columbia, MO
2954 — C0045 An In Vitro Pseudozonule
Model of Posterior Capsular Opacification:
Effects of Anti-Vascular Endothelial Growth
Factor-A Humanized Monoclonal Antibody
(Bevacizumab®) on Epithelial-to-Mesenchymal
Transition in Lens Epithelium. Jong Hwa Jun,
R. Kim. Ophthalmology, Keimyung University
Dongsan Medical Center, Daegu, Republic of Korea
2955 — C0046 The Effect of Sulfasalazine Hyaluronic Acid Complex on Posterior Capsule
Opacification. Choun-Ki Joo, J. Choi. Catholic
Institutes of Visual Science, Catholic Univ Korea
Coll of Med, Seoul, Republic of Korea
2956 — C0047 EGF-Receptor inhibitor
Gefitinib as a potential pharmacological
prophylaxis for posterior capsule opacification.
Peter Laubichler, C. M. Wertheimer, R. Liegl, M.
Kernt, A. Wolf, C. Haritoglou, A. Kampik, K. EiblLindner. Department of Ophthalmology, LudwigMaximilians-University, Munich, Germany *CR
2957 — C0048 Smad3 and MRTF regulation
of TGFβ−induced EMT in mouse lens explants.
Scott A. Bowman, A. Korol, M. Gupta, J. A.
West-Mays. Pathology and Molecular Medicine,
McMaster University, Hamilton, ON, Canada
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
208
Tuesday – Posters – 2958 – 2981
2958 — C0049 Role of Rho-ROCK signaling
in TGFβ-mediated MRTF-A localization during
EMT of LECs. Anna Korol, J. A. West-Mays.
Pathology and Molecular Medicine, McMaster
University, Hamilton, ON, Canada
2959 — C0050 Association of ocular ultraviolet
radiation exposure with the progression of
cataract in South Indian population. Rashima
Asokan1, 2, R. J. George2, V. Lingam2. 1Optometry,
Elite School of Optometry, Chennai, India;
2
Glaucoma, Sankara Nethralaya, Chennai, India
2960 — C0051 Identification of Peptides of
αA- and αB-Crystallins that are Present in
Cataractous Human Lenses but Not in AgeMatched Normal Lenses. Om P. Srivastava, K.
Srivastava, E. Tiwary. Vision Sciences, University
of Alabama at Birmingham, Birmingham, AL
2961 — C0052 Evaluation of the topographical
characteristics and elasticity of human anterior
lens capsule in cataract patients using atomic
force microscopy. Alpesh R. Patel, A. I. Arora, D.
A. Ganatra, F. B. Kayastha, R. Sankaranarayanan,
D. U. Gajjar, A. R. Vasavada. Iladevi Cataract and
IOL Research Centre, Ahmedabad, India f
2963 — C0054 Protective Effect of Caffeine
Against High Sugar Induced Transcription of
Micro-RNAs and Consequent Gene Silencing. A
Study Using Galactosemic Mice Lenses. Shambhu
D. Varma1, S. Kovtun2. 1Ophthal & Visual Sci &
Biochem, Univ of Maryland Sch of Med, Baltimore,
MD; 2Ophthalmology & Visual Sciences, University
of Maryland School of Medicine, Baltimore, MD
2964 — C0055 Regulation of Sumoylation
in Lens Epithelial Cells During Aging And
Oxidative Stress: Sumoylation Reduces
LEDGF’s Stability And DNA-Binding Efficiency.
Bhavana Chhunchha1, N. Fatma1, E. Kubo2, D.
P. Singh1. 1Ophthalmology & Visual Sciences,
Univ of Nebraska Medical Center, Omaha, NE;
2
Ophthalmology, Kanazawa Medical University,
Kanazawa, Japan
2965 — C0056 Hydrogen saline may prevent
selenite-induced cataract in rats. Hong Yan,
C. Yang. Department of Ophthalmology, Tangdu
Hospital, Fourth Military Medical University, Xian,
China
2966 — C0057 Role of apoptosis in the
development of senile cataract. Claudia Palacio,
M. Arredondo, O. Guerrero-Berger, L. ArroyoMuñoz, A. Robles-Contreras. Anterior Segment,
Fundacion Hospital Ntra. Sra. de la Luz, Naucalpan,
Edo. de Mex., Mexico
2968 — C0059 Characterization of Periaxin in
the lens and cataract formation. Deepika Arora1,
C. Xia1, J. Zeng1, Z. Huang2, M. Li1, X. Gong1.
1
School of Optometry, University of California,
Berkeley, Berkeley, CA; 2UCSF/UCB Joint
Graduate Program in Bioengineering, Berkeley, CA
2969 — C0060 Ontario Ginseng Extracts
Protect Against Cataract And Oxidative
Stress In Pig Lenses Exposed To High Energy
Proton And Neutron Irradiation. Tomasz M.
Dzialoszynski, E. Noble, G. Li, J. R. Trevithick.
School of Kinesiology, Western University, London,
ON, Canada
2970 — C0061 A Variant in the SLC35D1
gene is associated with Age-Related Cataract in
India. Periasamy Sundaresan1, R. D. Ravidran2,
P. Vashist3, S. Vijayan1, D. Nitsch4, G. Maraini5,
M. Camparini5, C. Usha6, J. F. Hejtmancik7,
A. E. Fletcher4. 1Genetics, Aravind Med Res
Foundation, Madurai, India; 2Aravind Eye Care
System, Madurai, India; 3Dr.Rajendra Prasad
Centre for Ophthalmic Sciences, All India Institute
of Medical Sciences, New Delhi, India; 4Faculty
of Epidemiology & Population Health, London
School of Hygiene & Tropical Medicine, London,
United Kingdom; 5Dipartimento di Scienze OtorinoOdonto-Oftalmologiche e Cervico Facciali, Sezione
di Oftalmologia Universita degli studi di Parma,
Parma, Italy; 6Centre for Vision & Vascular Science,
School of Medicine, Dentistry and BioMedical
Sciences, Queen’s University, Belfast, United
Kingdom; 7National Eye Institute, Bethesda, MD
2971 — C0062 Thermally induced cataract is
modulated by the biology of the lens. Zhaohua Yu,
N. Talebi Zadeh, M. Kronschlager, P. G. Söderberg.
Neuroscience/Opthalmology, Gullstrand Lab,
Uppsala, Sweden
2972 — C0063 A Targeted Proteomics
Approach Using Stable Isotope labeling To
Measure Sulfhydryl Oxidation In Human
Lens Crystallins. Larry L. David, E. E. Yue, P.
A. Wilmarth. Biochemistry & Molecular Biology,
Oregon Health Sciences Univ, Portland, OR
2973 — C0064 Human apoptotic proteome
of senile cataract. Atzin Robles-Contreras1, C.
Palacio2, M. Arredondo-Flores2, J. L. OlivaRamirez3, H. J. Perez-Cano1. 1Biomedical Research
Center, Hospital Foundation “Nuestra Senora de la
Luz,” Mexico, Mexico; 2Anterior Segment, Hospital
Foundation “Nuestra Senora de la Luz”, Mexico,
Mexico; 3Inmunoregulacion, ENCB-IPN, Mexico,
Mexico
2974 — C0065 Non-Homologous End Joining
Repair in the Lens. Andrew J. Smith1, K.
Manzar1, 2, M. Betts2, R. P. Bowater1, J. R. Reddan3,
M. Wormstone1. 1School of Biological Sciences,
University of East Anglia, Norwich, United
Kingdom; 2Norwich Medical School, University of
East Anglia, Norwich, United Kingdom; 3Oakland
University, Rochester, MI *CR
2975 — C0066 The effect of total lens epithelial
cell eradication on intraocular lens stability in
the human capsular bag. Julie A. Eldred1, S. L.
Russell1, R. P. Evans-Gowing1, M. Wormstone1, D.
Spalton2. 1School of Biological sciences, University
of East Anglia, Norwich, United Kingdom; 2The
Consulting Rooms, King Edward VII’s Hospital,
London, United Kingdom *CR
2976 — C0067 Expression of oxidative markers
in laser treated rat lenses. Thomas Holm, L.
Johnson, L. Kessel. Eye dep, Glostrup Hospital,
Glostrup, Denmark
2977 — C0068 Alpha-tocopherol protection
against UVR induced cataract, estimation
of confidence interval for MTD-2.3:16 and
comparison of MTD-2.3:16 estimates. Per G.
Soderberg, K. Galichanin, M. Kronschlager, Z. Yu,
N. TalebiZadeh. Gullstrand lab, Ophthalmology,
Dept of Neuroscience, Uppsala University, Uppsala,
Sweden
2978 — C0069 Cysteine delivery to the lens:
a strategy for delaying nuclear cataract? Julie
C. Lim1, 3, L. Lam1, 3, L. A. Peung1, 3, B. Li1, 3, P. J.
Donaldson2, 3. 1Optometry and Vision Science,
University of Auckland, Auckland, New Zealand;
2
School of Medical Sciences, University of
Auckland, Auckland, New Zealand; 3New Zealand
National Eye Centre, University of Auckland,
Auckland, New Zealand
2979 — C0070 Effects of Various Antioxidants
on Lens Epithelial Cells In Vitro and Ex
Vivo. Eric J. Miller1, A. J. Gemensky-Metzler1,
D. A. Wilkie1, C. M. Colitz4, 3, H. L. Chandler2,
1 1
. Veterinary Clinical Sciences, The Ohio State
University, Columbus, OH; 2Optometry, The Ohio
State University, Columbus, OH; 3All Animal Eye
Care, Jupiter, FL; 4Animal HealthQuest Solutions,
Jupiter, FL
2980 — C0071 The gender-different effects
of antioxidant supplement containing lutein on
the expression of aquaporin 8 in the lenticular
anterior capsule among cataract patients.
Rijo Hayashi1, S. Hayashi2, 1, K. Arai1, M. Sakai1,
M. Chikuda1. 1Ophthalmology, Koshigaya
Hospital,Dokkyo Medical University, Koshigaya,
Japan; 2Lively Eye Clinic, Soka, Japan
2981 — C0072 Genistein in various dietary
forms does not alter C-terminal truncation of
alphaA-crystallin in cataracts in ICR/f rats.
Stephen Barnes1, K. A. Floyd1, L. Wilson1, D.
M. Anderson2, K. L. Schey2. 1Pharmacology &
Toxicology, Univerity of Alabama at Birmingham,
Birmingham, AL; 2Biochemistry, Vanderbilt
University, Nashville, TN
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
209
Tuesday Posters
8:30 am – 10:15 am
2962 — C0053 Adult zebrafish with cataracts
show reduced OKR and altered color perception.
Heather Prior, R. Tuininga, K. Letwin, A. Tuininga.
Biology, The King’s University College, Edmonton,
AB, Canada
2967 — C0058 A Potential Molecular
Mechanism of Cataract Development in
CRYAAN101D Transgenic Mice Compared
to CRYAAWT Mice. Shylaja M. Hegde, K.
Srivastava, R. Joseph, O. P. Srivastava. Vision
Science, University of Alabama, Birmingham,
Birmingham, AL
2982 – 3007 – Tuesday – Posters
2982 — C0073 Conditional Expression of
hSVCT2 using αA-Crystallin Promoter with
Pax6 Consensus Binding Sites for Longterm Studies of Crystallin Ascorbylation and
Cataractogenesis in Mouse. Vincent M. Monnier1,
M. L. Robinson2, C. Strauch3, X. Fan3. 1Patho &
Biochem, Case Western Reserve Univ, Cleveland,
OH; 2Zoology, Miami University, Oxford, OH;
3
Pathology, Case Western Reserve University,
Cleveland, OH
Exhibit Hall C0074-C0104
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Lens / Clinical/Epidemiologic Research
319 Cataract Surgery III
Moderator: Frank J. Lovicu
Tuesday Posters
8:30 am – 10:15 am
2983 — C0074 Initial Results and Patient
Satisfaction After ReSTOR Multifocal TORIC
Intraocular Lens Implantation. Maan alkharashi,
M. Discepola. Ophthalmology, McGill University,
Montreal, QC, Canada *CR
2984 — C0075 Comparison of Refractive
Outcomes Following Phacoemulsification with
Intraocular Lens Implantation in Glaucoma,
Glaucoma Suspect, and Non-Glaucomatous
Patients. Greg Bever1, N. Morgenstern2, B. EliassiRad1. 1Ophthalmology, Boston University School of
Medicine, Boston, MA; 2Boston University School
of Public Health, Boston, MA
2985 — C0076 Intracameral moxifloxacin for
prophylaxis of endophthalmitis after cataract
surgery: A case Series. Leonardo Ferlini1, 2, L.
Perrone1, 2, G. Gomez Caride1, 2, M. M. Manotas2,
W. Biagini2, I. Saul2, G. Valvecchia1, 2. 1San Camilo,
Berazategui, Argentina; 2centro de ojos quilmes,
Quilmes, Argentina
2986 — C0077 Biometrical Measurements for
the Anterior Segment Dimensions of the Eye with
an Intraocular Lens during Accommodation.
Qi Chen1, L. Leng1, M. Shen1, J. Wang2, F. Lu1, D.
Chen1. 1School of Ophthalmology & Optometry,
Wenzhou Medical College, Wenzhou, China;
2
Bascom Palmer Eye Institute, University of Miami,
Miller School of Medicine, Miami, FL *CR
2987 — C0078 Reoperation After ResidentPerformed Cataract Surgery. Shivali A.
Menda1, T. Driver1, A. E. Neiman1, A. Naseri1, 2,
J. M. Stewart1. 1Department of Ophthalmology,
University of California- San Francisco, San
Francisco, CA; 2Ophthalmology, Veteran’s Affairs
Hospital, San Francisco, CA *CR
2988 — C0079 Astigmatism analysis in the
post-cataract surgery population: a retrospective
study. Stephan Ong Tone1, C. C. Law3, J. J. Ma2.
1
McGill University, Montreal, QC, Canada;
2
Ophthalmology, University of Toronto, Toronto,
ON, Canada; 3Queen’s University, Kingston, ON,
Canada *CR
2989 — C0080 Causes Of Implantable Contact
Lens Phakic Intraocular Lens Explantation/
Exchange at The King Khaled Eye Specialist
Hospital (KKESH). Nasser A. Al Sabaani3, 1, S. S.
Jastaneiah1, S. A. Al Motowa1, A. Behrens2, 1. 1King
Khaled Eye Specialist Hospital, Riyadh, Saudi
Arabia; 2The Wilmer Eye Institute, Riyadh, Saudi
Arabia; 3Ophthalmology, King khaled University,
Abha, Saudi Arabia
2990 — C0081 Title Prevalence of
Pseudoexfoliation and Complications of Cataract
Surgery in an Ethiopian Ancestry Population.
Leslie S. Jones1, B. A. Charles2, 1. 1Ophthalmology,
Howard University Hospital, Washington, DC;
2
Center for Research on Genomics and Global
Health, National Human Genome Research
Institute, Bethesda, MD
2991 — C0082 Outcomes of scleral-fixation of
intraocular lenses with fibrin glue. Kashif Baig, P.
Bastianelli, S. Teja. Ophthalmology, University of
Ottawa Eye Institute, Ottawa, ON, Canada *CR
2992 — C0083 Clinical Outcomes and
Complications of Iris Sutured Posterior
Chamber Intraocular Lens Implants. Alice Hong,
J. Kuryan, E. Wu, D. C. Ritterband, J. A. Seedor.
New York Eye and Ear Infirmary, New York, NY
*CR
2993 — C0084 Posterior Capsule Management
in Pediatric Cataract Surgery. W. Jordan Piluek1,
D. R. Fredrick1, 2. 1Ophthalmology, Stanford School
of Medicine, Palo Alto, CA; 2Lucile Packard
Children’s Hospital, Palo Alto, CA
2994 — C0085 Comparison of visual outcomes
after implantation of a toric or standard 1-piece
hydrophobic-acrylic aspheric intraocular
lens. Don R. Nixon1, K. Waltz2, D. Trentacost3, K.
Featherstone3, L. Tsai3, S. Kasthurirangan3. 1Tri
Med Laser Eye Center, Barrie, ON, Canada; 2TLC
Indiana, Eye Surgeons of Indiana, Indianapolis, IN;
3
Abbott Medical Optics Inc., Santa Ana, CA *CR, f
2995 — C0086 Cataractogenesis and surgical
outcome in patients with uveitis. Anne-Laure
Remond, E. Champion, V. Touitou, C. Fardeau, B.
Bodaghi, P. Le Hoang. 75013, la pitie salpetriere,
Paris, France *CR
2996 — C0087 Impact of changes in attending
staffing on major cataract complications at
Veterans Affairs Boston Healthcare System. Nikil
V. Moodabagil1, 2, J. Gonzalez Monroy1, 3, D. Trief1, 3,
M. K. Daly1, 2. 1Veterans Affairs-Boston Healthcare
System, Boston, MA; 2Boston University School of
Medicine, Boston, MA; 3Massachusetts Eye and Ear
Infirmary, Boston, MA
2997 — C0088 Retina evaluation with non
mydriatic ultra wide field color imaging after
cataract surgeries in asymptomatic patients.
Nicholas Faberowski2, 1, H. Quiroz-Mercado2, 1,
C. Gonzalez2, R. Bhandari1, S. Oliver1, J. Olson1,
N. Mandava1, S. Schwartz2. 1Ophthalmology,
University of Colorado, Aurora, CO; 2Denver
Health Hospital Authority, Denver, CO *CR
2998 — C0089 Early Uncorrected Vision in
Astigmatic Eyes Undergoing Microcoaxial
Phacoemulsification with Toric Lens
Implantation. David Wang2, R. Osher1. 1Cincinnati
Eye Institute, Cincinnati, OH; 2University of
Toledo, Toledo, OH *CR
2999 — C0090 Refractive outcome and patient
satisfaction after cataract surgery with mutifocal
intraocular lens implantation. Nabil El Kouhen,
H. Mnasri, S. Premy, A. Mouna, A. Agapie, A. Ferte,
F. Ameloot, J. Perone. Ophtalmology Department,
Regional Hospital Center Metz - Thionville, Mercy
Hospital, Metz, France
3000 — C0091 Tonometry in corneal edema
after cataract surgery: Rebound versus
Goldmann applanation tonometry. Matthias
Fuest, N. Mamas, N. Plange. Ophthalmology,
University Eye Hospital Aachen, Aachen, Germany
*CR
3001 — C0092 Cataract Prevalence and
Cataract Surgery Outcomes in Patients
with Ocular Graft-Versus-Host Disease
(GVHD). Ujwala S. Saboo, H. Shikari, R. Dana.
Massachusetts Eye and Ear Infirmary, Schepens Eye
Research Institute, Department of Ophthalmology,
Harvard Medical School, Boston, MA *CR
3002 — C0093 Assesment of Toric Intraocular
Lens Alignment by Ray Tracing System. Dr.
Vaibhav Sharma. Narayana Nethralaya Bangalore
India, Bangalore, India
3003 — C0094 Long-term stability of
intraocular lens and various types of capsular
tension ring in eyes with subluxated lens. HyungJoon Kim. Department of Ophthalmology, Daegu
Catholic Univ Hospital, Daegu, Republic of Korea
3004 — C0095 Utility of intraoperative
wavefront aberrometry in post-refractive
cataract patients. Anjali Tannan, R. J. Epstein, V.
Virasch, P. Majmudar, C. Faron, J. B. Rubenstein.
Ophthalmology, Rush University Medical Center,
Chicago, IL *CR
3005 — C0096 Upside-Down ACIOL
placement: A case series on complications,
management, and outcomes. Nisha Chadha1, L.
Olsakovsky2, B. D. Edgington1. 1Ophthalmology,
The George Washington University, Washington,
DC; 2Ophthalmology, University of Virginia,
Charlottesville, VA
3006 — C0097 Multifocal IOL implantation
in Patients with Uveitis. Sandra Hu-Torres1, 2, R.
Rasheed1, 2, C. Foster1, 3. 1Uveitis, Massachusetts
Eye Research and Surgery Institution, Cambridge,
MA; 2Ocular Immunology & Uveitis Foundation,
Cambridge, MA; 3Harvard Medical School, Boston,
MA *CR
3007 — C0098 MRI of the Capsular Bag in
Pseudophakic Human Donor Eyes. Lawrence
M. Strenk1, S. A. Strenk1, L. Werner2, N. Mamalis2.
1
MRI Research Inc, Middleburg Heights, OH;
2
Ophthalmology, University of Utah/Moran Eye
Center, Salt Lake City, UT *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
210
Tuesday – Posters – 3008 – 3030
3008 — C0099 Pseudoexfoliation Syndrome
is associated with deepening of the anterior
chamber in supine position and post-operative
hyperopic shift. Daniel Feiler1, 2, R. M. St Clair2, K.
C. Sippel2, C. E. Starr2. 1Ophthalmology, University
of Rochester School of Medicine and Dentistry,
Rochester, NY; 2Ophthalmology, Weill Cornell
Medical College, New York, NY
3009 — C0100 Cataract and Fuchs Dystrophy.
Celia V. Zinger, V. Borderie. Hopital des XV-XX,
Paris, France
3010 — C0101 Straylight changes after lens
exchange in eyes with good visual acuity. Thomas
J. Van Den Berg1, R. Lapid-Gortzak2, 3, I. J. van der
Meulen3. 1Ophthalmic Research, Netherlands Inst
for Neurosci, Royal Acad, Amsterdam, Netherlands;
2
Retina Eye Care, Driebergen, Netherlands; 3Dept
Ophthal AMC, Amsterdam, Netherlands *CR, f
3011 — C0102 Humphrey Visual Field
10-2 performance in eyes with multifocal
versus monofocal intraocular lens implants.
Garrick Chak, M. Farid, S. Garg, R. F. Steinert.
Ophthalmology, Gavin Herbert Eye Inst, UC Irvine,
Irvine, CA *CR
3013 — C0104 The role of intraocular lens
for prevention of secondary cataract formation.
Masamoto Aose, K. Mukai, H. Matsushima, N.
Gotoh, S. Tadashi. Ophthalmology, Dokkyo
Medical University, Tochigi, Japan *CR
Exhibit Hall C0177-C0193
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Visual Psychophysics / Physiological Optics /
Visual Neuroscience
320 Color Vision, Photoreceptor
Function, Adaptation
Moderator: Elise W. Dees
3014 — C0177 Is dark-adapted cone detection
optimized given noise and uncertainty? Darren
E. Koenig, H. J. Hofer. College of Optometry,
University of Houston, Houston, TX
3015 — C0178 Quick and easy light sensitivity
assessment of the dark adapted eye: The
Tuebingen Scotopic Threshold Test (TSTT).
Torsten Strasser, H. Langrová, A. Kurtenbach,
D. Zobor, D. Hillerkuss, E. Zrenner. Institute for
Ophthalmic Research, Centre for Ophthalmology,
Tuebingen, Germany *CR
3017 — C0180 Characteristics of Color
Visual Acuity by Step Changes of Background
Luminance in Young Subjects of Normal Eyes.
Yoshiki Tanaka1, K. Tanaka1, S. Yokoyama2, H.
Nakamura2, K. Ichikawa2, S. Tanabe3. 1Faculty of
Engineering, Shinshu University, Nagano, Japan;
2
Ophthalmology, Social Insurance Chukyo Hosp.,
Nagoya, Japan; 3Chukyo Eye Clinic, Nagoya, Japan
3018 — C0181 A Color Visual Function Test
to Evaluate the Age-Related Changes in Good
Visual Acuity of Normal Eyes. Sho Yokoyama1, K.
Ichikawa1, H. Nakamura1, S. Tanabe2, Y. Tanaka3,
K. Tanaka3, R. Horai2. 1Ophthalmology, Social
Insurance Chukyo Hosp, Nagoya, Japan; 2Chukyo
Eye Clinic, nagoya, Japan; 3Faculty of Engineering,
Shinshu University, Matsumoto, Japan
3019 — C0182 Training for Identification of
Colors Altered by Colored Filters. Thomas Kuyk1,
A. Smith1, S. Kumru2. 1TASC, Inc, Ft Sam Houston,
TX; 2Air Force Research Laboratory, Ft Sam
Houston, TX
3020 — C0183 Investigation of color vision
defect among dental practitioners. Hani Alarify,
N. Aldossari, A. Alharbi, A. Masmali, T. Almubrad.
Cornea Research Chair, Optometry Department,
College of Applied Medical Sciences, King Saud
University, Riyadh, Saudi Arabia
3021 — C0184 Dependence of the color brown
on the spatial configuration of high luminance
surrounds. Tanner DeLawyer, A. Frederick, S.
Kaplan, T. Lin, S. Shonka, S. L. Buck. Psychology,
University of Washington, Seattle, WA
3022 — C0185 Frequency of atypical genotypes
associated with normal and defective color
vision. Candice Davidoff, J. Neitz, M. Neitz.
Ophthalmology, University of Washington, Seattle,
WA *CR
3023 — C0186 Rod Hue Biases for Foveal
Stimuli on CRT Displays. Katharina G. Foote,
S. L. Buck. Psychology, University of Washington,
Seattle, WA
3024 — C0187 Fundus-controlled twocolor adaptometry with the Microperimeter
MP1. Wadim Bowl, B. Lorenz. Department of
Ophthalmology, Justus-Liebig-University, Giessen,
Germany *CR
3025 — C0188 Color Discrimination and Visual
Perimetry Evaluation in Multiple Sclerosis and
Neuromyelitis Optica. Phelipe A. Paixao1, 2, L. B.
Botelho Vergara1, 2, L. A. Almeida Fernandes1, 2, E.
C. Lacerda1, 3, G. S. Souza1, 3, H. Souza Cabeça5,
A. A. Rosa2, 4, L. L. Silveira1, 3. 1Nucleo de
Medicina Tropical, Universidade Federal do Para,
Belem, Brazil; 2Instituto de Ciencias da Saude,
Universidade Federal do Para, Belem, Brazil;
3
Instituto de Ciencias da Biologicas, Universidade
Federal do Para, Belem, Brazil; 4Hospital
Universitario Bettina Ferro de Souza, Universidade
Federal do Para, Belem, Brazil; 5Neurologia,
Hospital Ophir Loyola, Belem, Brazil
3026 — C0189 Psychophysical and
electrophysiological evaluation of visual function
in type 1 diabetics. Valéria D. Garcia1, 3, M.
Gualtieri3, 1, M. T. Barboni3, 1, D. M. Bonci3, 1,
T. L. Costa3, 1, B. V. Nagy1, 3, S. T. Rodrigues4,
A. L. Moura1, 3, F. Damico1, 2, D. F. Ventura1, 3.
1
Neuroscience and bahavior, University of São
Paulo, São Paulo, Brazil; 2Ophthalmology,
University of São Paulo, São Paulo, Brazil;
3
Experimental Psychology, University of São
Paulo, São Paulo, Brazil; 4Physical Education,
Universidade Estadual Paulista, Bauru, Brazil *CR
3027 — C0190 Psychophysical Measurement of
Rod and Cone Thresholds in Stargardt Disease
with Full-Field Stimuli. Frederick T. Collison1,
G. A. Fishman1, 2, J. McAnany2, J. Zernant3, R.
Allikmets3, 4. 1The Pangere Center for Hereditary
Retinal Diseases, The Chicago Lighthouse for
People Who Are Blind or Visually Impaired,
Chicago, IL; 2Department of Ophthalmology,
University of Illinois Chicago, Chicago, IL;
3
Department of Ophthalmology, Columbia
University, New York, NY; 4Department of
Pathology and Cell Biology, Columbia University,
New York, NY
3028 — C0191 Laser Eye Protection and
Visibility of Multi-Function Displays. Martin
LaFrance1, C. A. Williamson2, L. Svec3, T. Kuyk1.
1
Air Force Research Laboratory, Fort Sam Houston,
TX; 2Defence Science and Technology Laboratory,
Salisbury, United Kingdom; 3Defense Equal
Opportunity Management Institute, Patrick AFB, FL
3029 — C0192 Chromatic components
in underwater targets do not affect Great
cormorants’ (Phalacrocorax carbo) visual
resolution. Gadi Katzir1, 2, R. Almon1, I. Izhaki1.
1
Evolutionary and Environmental Biology,
University of Haifa, Haifa, Israel; 2Marine Biology,
University of Haifa, Haifa, Israel
3030 — C0193 High Throughput Behavioral
Estimates of Visual Thresholds in Mice in a
Watermaze with Cued Escape Platform. Arkady
Lyubarsky, M. Khan, M. Sivalingam, J. Bennett.
F.M. Kirby Center for Molecular Ophthalmology,
School of Medicine, University of Pennsylvania,
Philadelphia, PA *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
211
Tuesday Posters
8:30 am – 10:15 am
3012 — C0103 Refractive outcome and
subjective quality of vision after toric lens
implantation in cataract surgery. Heni Mnasri,
A. Mouna, N. El Kouhen, A. Agapie, A. Ferte,
S. Premy, F. Ameloot, P. Bertaux, J. Perone.
Ophthalmology department, Regional Hospital
Center Metz-Thionville, Mercy Hospital, METZ,
France
3016 — C0179 Dark Adaptation and the effect
of Oxygen Inhalation in Cystic Fibrosis. Rachel
Hiscox1, C. Purslow2, R. V. North1, I. Ketchell3, K.
Evans1. 1School of Optometry and Vision Sciences,
Cardiff University, Cardiff, United Kingdom;
2
School of Health Professions, Plymouth University,
Plymouth, United Kingdom; 3All Wales Adult
Cystic Fibrosis Centre, University Hospital Wales,
Cardiff, United Kingdom
3031 – 3052 – Tuesday – Posters
Exhibit Hall C0194-C0228
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Anatomy/Pathology
321 Anatomy
Moderator: Falk Schroedl
Tuesday Posters
8:30 am – 10:15 am
3031 — C0194 Clinical and Histopathologic
Characteristics in Floppy Eyelid Syndrome.
Karin U. Loeffler1, N. Stratmann2, T. Maeueler2,
F. G. Holz2, M. C. Herwig1. 1Ophthalmology,
Ophthalmic Pathology, University of Bonn, Bonn,
Germany; 2Ophthalmology, University of Bonn,
Bonn, Germany *CR
3032 — C0195 Spatial Relationship between
Bruch’s Membrane Opening and Lamina
Cribrosa Determines Optic Disc Tilting. PatMichael Palmiero1, S. Park1, 2, Y. Liu1, 3, C. F.
Netto1, R. L. Furlanetto1, M. Al-Jumayli1, J. M.
Liebmann1, 4, R. Ritch1, 2. 1Moise and Chella Safra
Advanced Ocular Imaging Laboratory, Einhorn
Clinical Research Center, New York Eye and
Ear Infirmary, New York, NY; 2Department of
Ophthalmology, New York Medical College,
Valhalla, NY; 3New York Medical College, Valhalla,
NY; 4Department of Ophthalmology, New York
University School of Medicine, New York, NY *CR
3033 — C0196 Endothelial Glycocalyx Layer
in the Aqueous Outflow Pathway of Bovine Eyes.
Chen-Yuan C. Yang1, 2, T. Huynh2, M. Johnson3,
H. Gong2, 1. 1Anatomy and Neurobiology, Boston
University, Boston, MA; 2Ophthalmology, Boston
University, Boston, MA; 3Biomedical Engineering,
Northwestern University, Evanston, IL
3034 — C0197 Comparative Ocular Anatomy
& Age-Related Ocular Changes of the Western
Lowland Gorilla. Clay Holley, N. Hogan.
Ophthalmology, UT-Southwestern Medical Center,
Dallas, TX
3035 — C0198 Assessment of ciliary muscle
morphology using a new Fourier domain swept
source anterior chamber optical coherence
tomographer. Phillip Buckhurst, H. Buckhurst, C.
Hamer. School of Health Professions, Plymouth
University, Plymouth, United Kingdom *CR
3036 — C0199 Comparative Anatomy of
Trabeculum and Smooth Zone (Schwalbe’s Line)
Widths of Various Primate and non-Primate
Eyes by Scanning Electron Microscopy (SEM).
Ann E. Barker-Griffith1, J. L. Abraham2, H. Fang2,
M. P. Breazzano1. 1Ophthalmology, SUNY Upstate
Med Univ, Syracuse, NY; 2Pathology, SUNY
Upstate Med Univ, Syracuse, NY *CR
3037 — C0200 Cell-ECM interactions during
formation of the zebrafish hyaloid vasculature.
Andrea E. Hartsock, J. M. Gross. Cell, Mol, and
Dev Biology, University of Texas, Austin, Austin,
TX
3038 — C0201 Dimensional Variation of the
Orbicularis Oculi Muscle in Non-preserved,
Fresh Frozen Human Cadavers. Bryan R. Costin1,
N. Sakolsatayadorn1, S. A. McNutt1, T. Rubinstein1,
G. Trichonas1, J. M. McBride2, J. D. Perry1. 1Cole
Eye Institute, Cleveland Clinic, Cleveland, OH;
2
Department of Anatomy, Cleveland Clinic Lerner
College of Medicine, Cleveland, OH *CR
3039 — C0202 Ocular Effects of Blood
Collection Techniques in Rabbits. Shwu-Fei Lee1,
S. D. Sorden1, D. G. Dunn1, P. J. Sonnentag1, A. J.
Dwyer2. 1Nonclinical Safety Assessment, Covance
Laboratories Inc., Madison, WI; 2College of
Veterinary Medicine, Iowa State University, Ames,
IA *CR
3040 — C0203 The Use of Commercially
Available Grafts in Lower Eyelid
Reconstruction. Neel Kumar1, 2, S. Shah1, 2, A.
B. al-Hariri1. 1Ophthalmology, Ochsner Clinic
Foundation, New Orleans, LA; 2Ophthalmology,
Louisiana State University Health Science Center,
New Orleans, LA
3041 — C0204 Outcomes of surgery for
removal of visually significant hyperplastic
persistent pupillary membranes. Courtney L.
Kraus, G. T. Lueder. Ophthalmology & Vision
Sciences, Washington University, Saint Louis, MO
3042 — C0205 Anatomical and Histologic
Evaluation of the Frontalis Muscle in
Non-Preserved, Fresh-Frozen Cadavers.
Stephen A. McNutt, B. R. Costin, T. Plesec, N.
Sakolsatayadorn, T. Rubinstein, G. Trichonas, J.
M. McBride, J. D. Perry. Ophthalmology, Cole Eye
Institute, Cleveland, OH *CR
3043 — C0206 Primary Blast-Induced Ocular
Trauma Modulated by Peak Pressure. Daniel
Sherwood1, B. Lund2, R. D. Glickman3, W. Gray4, R.
Watson1, K. Thoe5, W. E. Sponsel5, 1, M. A. Reilly1.
1
Biomedical Engineering, University of Texas at
San Antonio, San Antonio, TX; 2Institute of Surgical
Research, San Antonio, TX; 3University of Texas
Health Science Center at San Antonio, San Antonio,
TX; 4Geological Sciences, University of Texas at
San Antonio, San Antonio, TX; 5WESMDPA, San
Antonio, TX *CR
3044 — C0207 Positional Relationship Between
the Ethmoidal Foramina and the Optic Canal.
Eric S. Ahn2, 1, M. Mehta2, J. D. Perry2. 1Johns
Hopkins Hospital Wilmer Eye Institute, Baltimore,
MD; 2Cleveland Clinic Cole Eye Institute,
Cleveland, OH
3045 — C0208 A Computational Model for
Investigation of Ocular Trauma Due to Primary
Blast. Walter Gray1, R. Watson2, M. A. Reilly2, B.
Lund4, R. E. Sponsel5, R. D. Glickman3. 1Geological
Sciences, University of Texas at San Antonio,
San Antonio, TX; 2Biomedical Engineering,
University of Texas at San Antonio, San Antonio,
TX; 3Ophthalmology, University of Texas Health
Science Center-SA, San Antonio, TX; 4Ocular
Trauma, U.S. Army Institute of Surgical Research,
Fort Sam Houston, TX; 5Sponsel Professional
Association, San Antonio, TX *CR
3046 — C0209 Endonasal mitomicyn-C
during diode laser transcanalicular
dacryocystorhinostomy. Jorge E. Peraza Nieves,
J. Castellar Cerpa, P. Arribas Pardo, P. Bañeros,
J. Troyano Rivas, A. Romo Lopez. ophthalmology,
Hospital Clinico San Carlos, Madrid, Spain
3047 — C0210 Effects of Oxygen Level on In
Vitro Culture of Human Choroidal Melanocytes.
Solange Landreville1, 2, J. Guay1, 2, F. PagéLarivière1, 2. 1Ophtalmologie-ORL, Université
Laval, Québec, QC, Canada; 2LOEX/CUOrecherche, Centre de recherche du CHU de Québec,
Québec, QC, Canada
3048 — C0211 Diurnal Variation of Macular
Choroidal Volume in Healthy Volunteers. Natalia
Alpizar-Alvarez, E. Hernandez-Bogantes, L. Wu.
Instituto de Cirugía Ocular, San Jose, Costa Rica
*CR
3049 — C0212 Evaluating Choroidal
Microvascular Angiogenesis by Choroid
Sprouting Assay. Zhuo Shao1, M. Friedlander1,
C. G. Hurst1, Z. Cui1, L. Evans1, J. Chen1, P.
Sapieha2, S. Chemtob3, 2, J. Joyal1, L. E. Smith1.
1
Ophthalmology, Harvard Medical School, Boston
Children’s Hospital, Boston, MA; 2Ophthalmology,
Research Centers of Hôpital MaisonneuveRosemont, University of Montreal, Montreal,
QC, Canada; 3Pediatrics Ophthalmology and
Pharmacology, Research Centers of CHU SainteJustine, Montreal, QC, Canada
3050 — C0213 Distribution, morphology,
and dynamic behavior of macrophages in the
adult mouse choroid. Anil Kumar1, L. Zhao1, M.
Wang1, R. Fariss2, W. T. Wong1. 1Unit on NeuronGlia Interactions in Retinal Disease, National Eye
Institute, National Institute of Health, Bethesda,
MD; 2NEI Biological Imaging Core, National Eye
Institute,National Institute of Health, Bethesda, MD
3051 — C0214 Mast Cell Degranulation in
AMD Choroid. Gerard A. Lutty1, I. A. Bhutto1,
J. M. Seddon2, D. S. McLeod1. 1Wilmer Eye Inst,
Johns Hopkins Univ Sch of Med, Baltimore, MD;
2
Tufts Medical Center, Tufts U School of Medicine,
Boston, MA *CR
3052 — C0215 The Adult DCX-dsRed
Transgenic Rat Retina: Characterization of
DsRed Positive Cells. Andrea Trost1, F. Schroedl1, 2,
B. Bogner1, C. Strohmaier1, C. Runge1, G. Grabner1,
L. Aigner3, H. A. Reitsamer1. 1Ophthalmology/
Optometry, Paracelsus Medical University,
Salzburg, Austria; 2Anatomy, Paracelsus Medical
University, Salzburg, Salzburg, Austria; 3Molecular
Regenerative Medicine, Paracelsus Medical
University, Salzburg, Salzburg, Austria *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
212
Tuesday – Posters – 3053 – 3075
3053 — C0216 Lipid Peroxidation in the Rat
Retina after Elevated Intraocular Pressure.
Karen M. Joos1, R. Mernaugh2, R. Prasad1, P. Lu3,
L. Roberts4. 1Vanderbilt Eye Institute, Vanderbilt
University, Nashville, TN; 2Biochemistry,
Vanderbilt University, Nashville, TN; 3Biostatistics,
Vanderbilt University, Nashville, TN; 4Clinical
Pharmacology Division/Pharmacology, Vanderbilt
University, Nashville, TN *CR
3054 — C0217 Detection of the
neuroregulatory peptide alarin in cranial
autonomic ganglia of the rat. Falk Schroedl1, 2,
A. Kaser-Eichberger2, A. Trost2, C. Strohmaier2,
B. Bogner2, C. Runge2, B. Kofler3, H. A.
Reitsamer2. 1Ophthalmology and Anatomy,
Paracelsus University Salzburg, Salzburg, Austria;
2
Ophthalmology, Paracelsus University Salzburg,
Salzburg, Austria; 3Pediatrics, Laura-Bassi Centre
of Expertise, THERAPEP, Paracelsus University
Salzburg, Salzburg, Austria
3056 — C0219 Functional interactions between
Mmp-2 and Mmp-14a during axonal innervation
in the developing and regenerating zebrafish
optic tectum. Inge Van Hove, E. Janssens, D.
Gaublomme, K. Lemmens, L. K. Moons. KU
Leuven, Leuven, Belgium
3057 — C0220 Dissecting the primary site
of pathogenesis in COL4A1 related anterior
segment dysgenesis. Mao Mao, D. B. Gould.
Ophthalmology, Univ of California, SF Sch of Med,
San Francisco, CA
3058 — C0221 Effects of Retinopathy of
Prematurity (ROP) on Intraocular Structures.
James D. Akula1, 2, R. J. Munro1, A. Moskowitz1, 2,
R. M. Hansen1, 2, T. Y. Chui3, S. P. Prabhu4, 5, A.
B. Fulton1, 2. 1Ophthalmology, Boston Children’s
Hospital, Boston, MA; 2Ophthalmology, Harvard
Medical School, Boston, MA; 3Optometry, Indiana
University, Bloomington, IN; 4Radiology, Boston
Children’s Hospital, Boston, MA; 5Radiology,
Harvard Medical School, Boston, MA
3059 — C0222 PTF1a in anterior eye
development in zebrafish. C. Denwood, N.
Kheradiya, N. Luo, M. Conwell, R. M. Anderson, Y.
Sun. Ophthalmology, Indiana University Glick Eye
Institute, Indianapolis, IN *CR
3060 — C0223 Pathologic features, expression
and activity of MMPs in sclera from patients
with nanophthalmos. Jing Tao, N. Wang.
Beijing Tongren Eye Center, Beijing Tongren
Hospital,Capital Medical University, Beijing, China
3061 — C0224 Development, Composition,
and Architecture of the Mouse Ciliary Zonule.
Steven Bassnett, A. De Maria, Y. Shi. Ophthal &
Vis Science, Washington Univ Sch of Med, Saint
Louis, MO
3063 — C0226 Congenital eye defects due to
failure of embryonic eyelid closure. Qinghang
Meng, M. Mongan, J. Zhang, Y. Xia. Universiity of
Cincinnati, Cincinnati, OH
3064 — C0227 The Developmental Roles
of c-Jun in Ocular Surface Epithelium.
Maureen Mongan1, Q. Meng1, W. Kao2, Y. Xia1, 2.
1
Environmental Health, University of Cincinnati,
Cincinnati, OH; 2Ophthalmology, University of
Cincinnati, Cincinnati, OH
3065 — C0228 The functional significance of
zinc-finger protein Nlz2 in optic fissure closure.
Grace Shih1, 2, R. Alur1, F. I. Onojafe1, B. P. Brooks1.
1
National Eye Institute, Bethesda, MD; 2Howard
Hughes Medical Institute, Bethesda, MD
Exhibit Hall D0001-D0036
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Cornea
322 Corneal Surgery Non-refractive I
Moderator: Frank Larkin
3066 — D0001 A quantitative approach to
evaluate the overall quality of cornea used in a
comparative study between two hypothermic
storage media. Mohit N. Parekh1, G. Salvalaio2, S.
Ferrari1, M. Amoureux3, C. Albrecht3, D. Fortier3,
D. Ponzin1, 2. 1Epithelial Stem Cell Research Center,
The Veneto Eye Bank Foundation, Venice, Italy;
2
Eye Bank, The Veneto Eye Bank Foundation,
Venice, Italy; 3Eurobio, Paris, France *CR
3067 — D0002 Assessment of The Quality
of Life and Psychometric Assessment After
Keratoplasty with VFQ-25. Daisuke Tomida,
Y. HIrayama, S. Den, K. Konomi, Y. Satake, J.
Shimazaki. Ophatlmology, Tokyo Dental College
Ichikawa Jeneral Hospital, Ichikawa, Japan *CR, f
3068 — D0003 Two year visual acuity
and contrast sensitivity outcome following
Descemet’s Stripping Automated endothelial
keratoplasty (DSAEK) and the correlation with
preoperative donor graft thickness. Fiona Pin
Miao P. Lim1, M. Ang1, 2, H. M. Htoon1, 2, D. T.
Tan1, 2, J. S. Mehta1, 2. 1Ophthalmology, Singapore
National Eye Centre, Singapore Eye Research
Institute, Singapore, Singapore; 2Ophthalmology,
National University of Singapore, Yong Loo Lin
School of Medicine, Singapore, Singapore *CR
3069 — D0004 Comparison of Dehydration
Kinetics of Organ Cultured Human Corneas
by Different Deswelling Media using Optical
Coherence Tomography. Martin Hermel, S.
Salla, N. Hamsley, P. Walter, A. C. Rieck. Dept of
Ophthalmology and Aachen Cornea Bank, RWTH
Aachen University, Aachen, Germany *CR
3070 — D0005 The influence of donor factors
on suitability of corneas for penetrating
keratoplasty. John Armitage1, M. N. Jones2, I.
Zambrano3, F. M. Carley3, D. M. Tole1. 1Clinical
Sciences, Univ of Bristol-Bristol Eye Hosp, Bristol,
United Kingdom; 2NHS Blood and Transplant,
Bristol, United Kingdom; 3Manchester Royal Eye
Hospital, Manchester, United Kingdom
3071 — D0006 Comparison of
Neovascularization, Opacification and Cornea
thickness in a Rabbit Model of Keratoplasty with
Interrupted or Continuous Suture Techniques
by Cornea fluorescein angiography and corneal
OCT. Maria A. Parker1, T. J. McFarland1, W.
Chamberlain1, S. Ellis2, K. Mitrophanous2, T. Stout1.
1
Casey Eye institute, OHSU, Portland, OR; 2OBM
UK limited, Oxford, United Kingdom *CR
3072 — D0007 Most frequent indications for
keratoplasty at 2 academic centers over a 6-year
period. Kimberly Hsu1, S. Chang4, 1, W. Brothers2,
S. L. Edelstein2, H. Y. Hsu3, 2, G. J. Harocopos1.
1
Ophthalmology, Washington University in St.
Louis, St. Louis, MO; 2Ophthalmology, Saint
Louis University, St. Louis, MO; 3Ophthalmology,
University of Southern California, Los Angeles,
CA; 4Ophthalmology, University of Washington,
Seattle, WA *CR
3073 — D0008 Outcome of Combined
Penetrating Keratoplasty and Vitreoretinal
Surgery using Temporary Eckardt
Keratoprosthesis and Analysis for Factors
affecting Corneal Allograft Survival. Dae Seung
Lee1, J. Heo1, M. Kim1, H. Choi2, W. Wee1, J. Oh1.
1
Ophthalmology, Seoul National University, Seoul,
Republic of Korea; 2Seoul National University
Hospital Healthcare System Gangnam Center,
Seoul, Republic of Korea
3074 — D0009 Comparison Of Graft Survival
Following Penetrating Keratoplasty And
Descemet’s Stripping Endothelial Keratoplasty
In Medically And Surgically Treated Glaucoma
Patients. George C. Papachristou, D. S. Greenfield,
T. P. O’Brien, J. C. Schiffman, W. Shi, S. M. Iverson.
Ophthalmology, Bascom Palmer Eye Institute, Palm
Beach Gardens, FL *CR
3075 — D0010 Self-retained amniotic
membrane for high-risk penetrating keratoplasty
- one-year results. Pho Nguyen1, R. N. Swamy1, K.
Rue1, J. M. Heur1, S. C. Yiu2, 3. 1Doheny Eye Inst,
USC / Keck School of Medicine, Los Angeles, CA;
2
Wilmer Eye Inst, Johns Hopkins Univ, Baltimore,
MD; 3King Khaled Eye Specialist Hospital, Riyadh,
Saudi Arabia
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
213
Tuesday Posters
8:30 am – 10:15 am
3055 — C0218 Immunohistochemical Features
of Encapsulated Blebs Following Ahmed
Glaucoma Valve Implantation. Fatima Fikri1,
D. P. Edward1, 2, S. A. Al Shahwan1, K. Al Hati1, I.
Al Jadaan1. 1King Khaled Eye Specialist Hospital,
Riyadh, Saudi Arabia; 2The Wilmer Eye Institute/
Johns Hopkins Hospital, Baltimore, MD
3062 — C0225 Closing the gap: development
of a novel zebrafish-based tool to assess optic
fissure closure. Pamela R. Pretorius1, Y. Agamawi1,
J. M. Hatler1, S. L. Lerach1, F. Qi2, B. Zhang2, B.
R. Bill3, S. Lin4, L. A. Schimmenti1. 1Department of
Pediatrics, University of Minnesota, Minneapolis,
MN; 2College of Life Sciences, Peking University,
Beijing, China; 3Semel Institute for Neuroscience
and Human Biology, UCLA, Los Angeles, CA;
4
Department of Molecular, Cell and Developmental
Biology, UCLA, Los Angeles, CA
3076 – 3101 – Tuesday – Posters
3076 — D0011 Anterior Chamber Depth
and Penetrating Keratoplasty Graft Survival.
Christine N. Pham Lagler, W. M. Munir.
Ophthalmology, Boston University School of
Medicine, Boston Medical Center, Boston, MA
3077 — D0012 A new anvil profile in
femtosecond laser assisted penetrating
keratoplasty. Luca Menabuoni1, I. Lenzetti1, A.
Canovetti1, A. Malandrini1, F. Rossi2, R. Pini2. 1U O
Oculistica, Ospedale Misericordia and Dolce, Prato,
Italy; 2Institute of Applied Physics “Nello Carrara”,
Italian National Research council, Sesto Fiorentino
(FI), Italy
Tuesday Posters
8:30 am – 10:15 am
3078 — D0013 Sutureless Penetrating
Keratoplasty Using a Femtosecond Laser. A
Laboratory Approach. Ashley Behrens1, 2, H. M.
Alkatan2, E. Badawy2, F. Alanazi2, N. Alsabaani2,
A. Aljaethen2. 1Ophthalmology, Johns Hopkins
Wilmer Eye Inst, Baltimore, MD; 2Ophthalmology,
King Khaled Eye Specialist Hospital, Riyadh, Saudi
Arabia
3079 — D0014 Descemet’s Membrane
Endothelial Keratoplasty (DMEK) : Overstripping the graft bed promotes donor
adherence. Michael D. Straiko, M. A. Terry, J.
Talajic, D. Davis-Boozer. Ophthalmology, Devers
Eye Institute, Portland, OR *CR
3080 — D0015 Pachymetry Assisted Lamellar
Keratoplasty for Corneal Ectasia. Julio C.
Hernandez-Camarena1, V. M. Boullosa1, A.
Navas1, A. J. Ramirez-Miranda1, C. Carriazo2, E.
O. Graue-Hernández1. 1Cornea and Refractive
Surgery, Instituto de Oftalmología “Conde de
Valenciana”, Mexico City, Mexico; 2Anterior
Segment and Refractive Surgery, Carriazo Scientific
Organization, Barranquilla, Colombia *CR
3081 — D0016 DSAEK & DMEK Triples: How
close are we to achieving emmetropia? David
Davis-Boozer1, M. A. Terry2, 1, M. D. Straiko2, J.
Talajic2, A. A. Alqudah2, M. A. Greiner2. 1Lions
VisionGift, Portland, OR; 2Devers Eye Institute,
Portland, OR *CR
3082 — D0017 Surface topography and
3-dimensional Confocal Profiling of Femtosecond
and Mechanical Microkeratome Dissected
Posterior Human Corneal Buttons. Mor M.
Dickman1, M. van Maris2, T. Berendschot1, R.
M. Nuijts1. 1University Eye Clinic Maastricht,
Maastricht University Medical Center, Maastricht,
Netherlands; 2Faculty of Mechanical Engieneering,
Technical University Eindhoven, Eindhoven,
Netherlands *CR
3083 — D0018 Use of intraoperative Optical
Coherence Tomography to evaluate graft-host
interface separation in Descemet Stripping
Automated Endothelial Keratoplasty. Katie
Hallahan, G. M. Smith, J. P. Ehlers, J. Goshe. Cole
Eye Institute, Cleveland, OH *CR
3084 — D0019 Comparison of time-domain
with spectral-domain OCT for detection of graft
detachments following DMEK. Philipp Steven,
C. Le Blanc, S. E. Siebelmann, L. M. Heindl, C.
Cursiefen. Ophthalmology, University of Cologne,
Cologne, Germany *CR
3085 — D0020 In Vivo Confocal Microscopy to
Detect the Wound Healing Process after DSAEK
and nDSAEK. Jen-Pin Sun, W. Chen, Y. Lin, C.
Peng, F. Hu. Ophthalmology, National Taiwan
University Hospital, Taipei, Taiwan
3086 — D0021 Reproducibility of graft
preparations in Descemet membrane endothelial
keratoplasty. Kathrin Rössler, U. SchlotzerSchrehardt, B. O. Bachmann, F. E. Kruse.
Department of Ophthalmology, University of
Erlangen-Nürnberg, Erlangen, Germany
3087 — D0022 Low-energy and high-frequency
femtosecond laser in the production of donor
corneal lamellae. Gustavo Victor1, W. Nosé3, S. J.
Sousa2, M. R. Alves1. 1Ophthalmology, University
of Sao Paulo, Sao Paulo, Brazil; 2Ophthalmology,
University of Sao Paulo - FMRP, Ribeirao Preto,
Brazil; 3Ophthalmology, Federal University of Sao
Paulo, Sao Paulo, Brazil
3088 — D0023 Tears of post-LASIK corneal
donor tissue during surgeon-performed donor
graft preparation for DSAEK. Drew Davis1,
P. A. Karth1, C. Croasdale2, 3, S. B. Koenig1.
1
Medical College of Wisconsin, Wauwatosa,
IN; 2Ophthalmology, Davis Duehr Dean Clinic,
Madison, WI; 3University of Wisconsin School of
Medicine and Public Health, Madison, WI
3089 — D0024 DSAEK for Corneal
Decompensation After Ex-Press Shunt
Surgery -A Case Series. Jayne S. Weiss1, S.
Shah1, H. Thompson2, C. Bovone3. 1Department
of Ophthalmology, LSU, New Orleans, LA;
2
Biostatistics Section, School of Public Health,
LSUHSC, New Orleans, LA; 3Villa Igea Hospital,
Forli, Italy
3090 — D0025 Morphological study of
posterior corneal grafts obtained for DSAEK
comparing two different harvesting techniques.
Juan A. Duran, E. Díez-Feijóo. Instituto de
Oftalmología, Basque Country University, Bilbao,
Spain
3091 — D0026 DSAEK: Endothelial cell loss is
greater for Pseudophakic Bullous Keratopathy
than for Fuchs’ Dystrophy. Julia Talajic1, M. A.
Terry1, M. D. Straiko1, A. A. Alqudah1, D. DavisBoozer2. 1Devers Eye Institute, Portland, OR; 2Lions
VisionGift, Portland, OR *CR
3092 — D0027 Changes in contrast sensitivity
and color vision after Descemet membrane
endothelial keratoplasty. Javier Cabrerizo1, 2,
K. van Dijk1, P. Leeuwenburgh1, F. U. Musa1, J.
Urcola2, G. Melles1. 1Netherlands Institute for
Innovative Ocular Surgery (NIIOS), Rotterdam,
Netherlands; 2Ophthalmology, Hospital
Universitario de Araba, Vitoria, Spain *CR, f
3093 — D0028 Risk Factors for Adjuvant
Glaucoma Therapy and Graft Failure in
Descemet’s Stripping Automated Endothelial
Keratoplasty Patients. Carrie Zaslow, P. Petrakos,
A. Angelilli, I. J. Udell, C. Shih. North Shore LIJ
Department of Ophthalmology, New Hyde Park,
NY
3094 — D0029 Descemet’s Membrane
Endothelial Keratoplasty (DMEK): Early results
using eye bank prepared, pre-stripped donor
tissue in the first 43 cases. Mark A. Terry, M.
D. Straiko, J. Talajic, D. Davis-Boozer. Corneal
Services, Devers Eye Institute, Portland, OR *CR
3095 — D0030 Adverse effects of Systemic
Cyclosporin A in High-risk Keratoplasty. Jong
Joo Lee1, 2, M. Kim1, 2, W. Wee1, 2. 1Department of
Ophthalmology, Seoul National University College
of Medicine, Seoul, Republic of Korea; 2Laboratory
of Corneal Regenerative Medicine and Ocular
Immunology, Seoul National University Hospital
Biomedical Research Institute, Seoul, Republic of
Korea
3096 — D0031 Immediate postoperative
local Descemet membrane detachments and
interface fluid pockets after DMEK vary
in location and degree as shown by optical
coherence tomography. Carolin Le Blanc, S. E.
Siebelmann, L. M. Heindl, C. Cursiefen, P. Steven.
Ophthalmology, University of Cologne, Cologne,
Germany *CR
3097 — D0032 The comparative analysis of
clinical outcome in penetrating keratoplasty in
use of domestic or imported cornea from UnitedStates in South Korea. Ja Young Lee1, 2, M. Kim1, 2,
J. Oh1, 2, H. Choi1, 2, W. Wee1, 2. 1Seoul National
University Hospital, Seoul, Republic of Korea;
2
Laboraory of Corneal Regenerative Medicine and
Ocular Immunology, Seoul Artificial Eye Center,
Seoul, Republic of Korea
3098 — D0033 Outcomes of Thin Lenticule
Descemet Stripping Automated Endothelial
Keratoplasty using a Single-Pass Microkeratome
technique. Prafulla K. Maharana, N. Sharma, R. B.
Vajpayee. Opthalmology, R.P.Centre, AIIMS, New
Delhi, India
3099 — D0034 Clinical outcome of repeat
penetrating keratoplasty. Margareta Claesson1, J.
Armitage2. 1Ophthalmology, Sahlgrenska University
Hospital, Mölndal, Sweden; 2Clinical Sciences,
University of Bristol, Bristol, United Kingdom
3100 — D0035 Femtosecond Laser “MiniBubble” Deep Lamellar Dissection for DALK
and DSAEK. Roger F. Steinert, M. Farid, S. Garg,
M. Wade. Ophthalmology, Gavin Herbert Eye
Institute, UC Irvine, Irvine, CA *CR
3101 — D0036 Corneal thickness after
posterior lamellar keratoplasty. Anders Ivarsen,
J. Hjortdal, N. Aagaard, J. Hedegaard, H. Sejersen,
C. Møller. Ophthalmology, Aarhus University
Hospital, Aarhus, Denmark *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
214
Tuesday – Posters – 3102 – 3124
Exhibit Hall D0037-D0082
Tuesday, May 07, 2013 8:30 AM-10:15 AM
Cornea
323 Corneal Surgery Refractive
Moderator: Olivier Richoz
3102 — D0037 Role of Subconjunctival
Bevacizumab in Post-Pterygium Excision
Management. Sonia B. Dhoot1, H. Guan2, K.
Tokuhara3. 1Ophthalmology, University of Missouri
Kansas City, Kansas City, MO; 2Ophthalmology,
Loma Linda Medical Center, Loma Linda, CA;
3
Ophthalmology, Arrowhead Regional Medical
Center, Colton, CA f
3103 — D0038 The effect of pterygium surgery
on corneal astigmatism. Clinton J. Duncan, S.
Logan, K. L. Anderson. Ophthalmology, University
of Texas Health Science Center at San Antonio, San
Antonio, TX
3105 — D0040 Comparison of fibrin glue and
autologous blood for conjunctival autograft
fixation in pterygium surgery. Salina Teja, S.
Boucher, K. Baig. Ophthalmology, University of
Ottawa Eye Institute, Ottawa, ON, Canada *CR
3106 — D0041 Expression of the proinflammatory molecule RAGE in human
pterygia. Elia J. Duh1, S. A. Al-Swailem2, Z. Xu1, S.
C. Yiu1, 2, L. Wu1. 1Ophthalmology, Johns Hopkins
Wilmer Eye Inst, Baltimore, MD; 2King Khaled Eye
Specialist Hospital, Riyadh, Saudi Arabia
3107 — D0042 Effect of Porcine Chondrocyte
Derived Extracellular Matrix on the Pterygium
in Mouse Model. Kyeong Hwan Kim1, 2, H. Lee2,
J. Yang1, 2. 1Department of Ophthalmology, Inje
University College of Medicine, Busan, Republic of
Korea; 2Ocular Neovascular Research Center, Inje
University Busan Paik Hospital, Busan, Republic
of Korea
3108 — D0043 Linear systems analysis of
Pre and Post Operative Zernike Coefficients
in LASIK Surgery. Daniel R. Neal1, T. D.
Raymond1, A. Saliba2, J. V. Treyes2. 1Research and
Development, AMO WaveFront Sciences, LLC,
Albuquerque, NM; 2Research and Development,
AMO Development Inc, Milpitas, CA *CR, f
3109 — D0044 A novel model of digitized
clinical validation of femtosecond LASIK flap
diameter and opaque bubble layer (OBL)
incidence. Ioanna Kontari1, G. Asimellis1, A.
Kanellopoulos1, 2. 1LaserVision.gr Eye Institute,
Athens, Greece; 2NYU Medical School, New York,
NY *CR
3111 — D0046 Post-keratoplasty astigmatism
correction with Toric Intraocular Lenses.
Matthew Wade, R. F. Steinert, S. Garg, M. Farid.
UC Irvine, Irvine, CA *CR
3112 — D0047 Comparison of LaserAssisted Removal of Epithelium to Mechanical
Debridement in Corneal Cross-Linking for
Progressive Keratoconus: 12-Months Results.
Ana Laura C. Canedo, R. N. Gaster, Y. S.
Rabinowitz. Cornea Genetic Eye Institute, Beverly
Hills, CA *CR
3113 — D0048 Pachymetry map of corneal
epithelium in patients wearing orthokeratology
contact lenses. Yishan Qian. Ophthalmology, Eye
and ENT hospital Fudan University, Shanghai,
China
3114 — D0049 Patient Satisfaction and Quality
of Vision after Wavefront-guided (WFG) vs.
Wavefront-optimized (WFO) LASIK. Rose K.
Sia1, R. D. Stutzman2, J. F. Pasternak2, D. S. Ryan1,
J. B. Eaddy1, L. A. Logan1, L. Peppers1, E. W. Trudo1,
K. S. Bower3. 1US Army Warfighter Refractive Surg
Research Ctr, Fort Belvoir Community Hospital,
Fort Belvoir, VA; 2Ophthalmology, Walter Reed
National Military Medical Center, Bethesda, MD;
3
The Wilmer Eye Institute, Johns Hopkins University,
Baltimore, MD f
3115 — D0050 Biomechanical changes in
Human Corneas after Low and High Intensity
Collagen Cross-Linking Treatment measured
using Scanning Acoustic Microscopy. Ithar M.
Beshtawi1, R. Akhtar2, C. Hillarby3, C. O’Donnell1, 4,
X. Zhao5, A. Brahma6, F. M. Carley6, B. Derby5,
H. Radhakrishnan1. 1Faculty of Life Sciences, The
University of Manchester, Manchester, United
Kingdom; 2School of Engineering, University of
Liverpool, Liverpool, United Kingdom; 3School of
Clinical and Laboratory Science, The University
of Manchester, Manchester, United Kingdom;
4
Optegra, Manchester, United Kingdom; 5School
of Materials, The University of Manchester,
Manchester, United Kingdom; 6Manchester Royal
Eye Hospital, Manchester, United Kingdom
3116 — D0051 Inflammatory and lacrimal
gland proteins in the tear film after femtosecond
LASIK. Andrea Petznick1, L. Zhou1, 3, R. W.
Beuerman1, 3, S. Koh1, L. Tong2, 1, J. S. Mehta2, 1.
1
Ocular Surface Research Group, Singapore
Eye Research Institute, Singapore, Singapore;
2
Singapore National Eye Centre, Singapore,
Singapore; 3Duke-NUS Graduate Medical School,
Singapore, Singapore *CR, f
3117 — D0052 The PEDF neuroprotective
domain plus DHA selectively induces corneal
nerve regeneration after experimental surgery.
Maria S. Cortina1, J. He2, 3, A. H. Kakazu2, 3, N. G.
Bazan2, 3, H. E. Bazan2, 3. 1Ophthalmology, Univ
of Illinois Eye & Ear Infirmary, Chicago, IL;
2
Neuroscience, Louisiana State University, New
Orleans, LA; 3Ophthalmology, Louisiana State
University, New Orleans, LA
3118 — D0053 A limitation of HartmannShark system in measuring wavefront
aberrations for patients received laser refractive
surgery. Ying Wu1, J. C. He2, X. Zhou1, R. Chu1.
1
Ophthalmology, Eye and ENT hospital of Fudan
University, Shanghai, China; 2New England College
of Optometry, Boston, MA
3119 — D0054 Correlation of Temperature and
Humidity to the Incidence of LASIK Flap Striae
In A Very High Volume Refractive Surgery
Center. Neema Nayeb-Hashemi1, R. R. Krueger1,
M. Tomita2. 1Ophthalmology, Cleveland Clinic
Foundation Cole Eye Institute, Cleveland, OH;
2
Ophthalmology, Shinagawa LASIK Center, Tokyo,
Japan *CR
3120 — D0055 Flap-induced aberrations for
the LASIK refractive surgery. Stan Bentow, A.
Fabrikant, G. G. Dai. Abbott Medical Optics, Santa
Ana, CA *CR
3121 — D0056 Correlation between the
changes in corneal power and visual outcome
following inlay implantation. Eon Kim1, 2, K.
Ehrmann2, 3, J. A. Moilanen4, J. D. Choo4, S.
Franz3, 4. 1Vision CRC, Sydney, NSW, Australia;
2
School of Optometry and Vision Science,
University of New South Wales, Sydney, NSW,
Australia; 3Brien Holden Vision Institute, Sydney,
NSW, Australia; 4Adventus Technology, Inc, Irvine,
CA *CR
3122 — D0057 Evaluation of femtosecond
laser-assisted combined Descemet’s stripping
automated endothelial keratoplasty (DSAEK)
and astigmatic keratotomy (AK) surgery. Kathy
M. Tran1, S. Wang1, I. Kontari2, G. Asimellis2, A.
Kanellopoulos1, 2. 1New York Univ School of Med,
New York, NY; 2LaserVision.gr Eye Institute,
Athens, Greece *CR
3123 — D0058 Photorefractive keratectomy
after deep anterior lamellar keratoplasty.
Pichaporn Artornsombudh, Y. Goldich, N. AvniZauberman, U. Elbaz, S. Ziai, D. Rootman.
Ophthalmology, University of Toronto, Toronto,
ON, Canada *CR
3124 — D0059 Comparison of the Ocular
Response Analyzer and the Belin-Ambrósio
Ectasia Display for Detecting Eyes at High
Risk of Developing Ectasia After Refractive
Surgery. Maria Eugenia Vola Ravina1, R. Lisboa1,
P. Schimchak3, K. J. Kishi2, N. A. Afshari1, D. J.
Schanzlin4. 1Ophthalmology, University of San
Diego California, La Jolla, CA; 2University of
Calgary, Calgary, AB, Canada; 3Cornea, CETAO,
Montevideo, Uruguay; 4Gordon-Weiss-Schanzlin,
La Jolla, CA *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
215
Tuesday Posters
8:30 am – 10:15 am
3104 — D0039 Pterygiums: A Resident
Experience with Recurrence and Complications.
Adam Sise1, 2, T. Banker1, 2, W. Chang1, 2, S. Pillai1.
1
Ophthalmology, Georgetown University Hospital,
Washington, DC; 2Ophthalmology, Washington
Hospital Center, Washington, DC
3110 — D0045 The effect of procedure room
temperature and humidity on LASIK outcomes.
Michael I. Seider1, S. D. McLeod1, T. Porco1, S.
C. Schallhorn1, 2. 1Ophthalmology, University of
California, San Francisco, San Francisco, CA;
2
Optical Express, Inc., Glasgow, United Kingdom
*CR
Tuesday Posters
8:30 am – 10:15 am
3125 – 3147 – Tuesday – Posters
3125 — D0060 Visual Performance
Comparison of Wavefront-optimized and
Wavefront-guided Laser in situ keratomileusis
(LASIK). Kraig S. Bower1, L. Peppers2, R. K. Sia2,
R. D. Stutzman3, J. F. Pasternak3, D. S. Ryan2, E.
W. Trudo2. 1Ophthalmology, Wilmer Eye Institute,
Lutherville, MD; 2US Army Warfighter Refractive
Surg Research Ctr, Fort Belvoir Community
Hospital, Fort Belvoir, VA; 3Ophthalmology, Walter
Reed National Military Medical Center, Bethesda,
MD f
3133 — D0068 Evaluation of Limbal
Ultrastructure in Twelve Year and Twentyeight Year Post-operative Keratoconic
Corneas. Erin Dooley1, S. Gardner1, S. Hayes1,
J. Harris1, K. Nielsen3, J. Hjortdal3, T. Sorensen2,
N. Terrill2, C. Boote1, K. M. Meek1. 1Biophysics,
Cardiff University School of Optometry and
Vision Sciences, Cardiff, United Kingdom;
2
Diamond Light Source, Didcot, United Kingdom;
3
Department of Ophthalmology Aarhus University
Hospital, Arhus, Denmark *CR
3126 — D0061 Incidence and Factors
Associated with Microbial Keratitis in a Large
Cohort of Consecutive Corneal Refractive
Surgery Patients. Steven C. Schallhorn, J.
M. Schallhorn, A. Padilla. Department of
Ophthalmology, UCSF, San Diego, CA *CR
3134 — D0069 Evaluate the safety and
efectiveness of the AcrySof Phakic Angle
supported intraocular Lens for the correction
of high myopia. Mireya G. Arellano. Fundacion
Hospital Nuestra Señora de la Luz, Distrito Federal,
Mexico
3127 — D0062 Refractive Surgery for
Accommodative Esotropia in Special Needs
Children and Adolescents. Nicholas Faron, J.
Hoekel, L. Tychsen. Ophthalmology & Visual
Sciences, Washington Univ Sch Med, St. Louis,
MO
3135 — D0070 Patient Satisfaction and Quality
of Vision after Wavefront-guided (WFG) vs.
Wavefront-optimized (WFO) Photorefractive
keratectomy (PRK). Denise S. Ryan1, R. K. Sia1,
R. D. Stutzman2, J. F. Pasternak2, L. Peppers1, J. B.
Eaddy1, L. A. Logan1, E. W. Trudo1, K. S. Bower3.
1
US Army Warfighter Refractive Surg Research Ctr,
Fort Belvoir Community Hospital, Fort Belvoir,
VA; 2Ophthalmology, Walter Reed National Military
Medical Center, Bethesda, MD; 3The Wilmer Eye
Institute, Johns Hopkins University, Baltimore, MD f
3128 — D0063 Is calculation of corneal tissue
ablation depth determined by VISX Star S4 IR
platform’s algorithm a reliable method? Juan A.
Curiel, C. Pacheco-Del-Valle, O. Baca, A. Babayan,
R. Velasco. Fundación Hospital “Nuestra Señora de
la Luz” IAP, Mexico City, Mexico
3129 — D0064 Bilateral Implantation
of Hydrogel Corneal Inlays in Hyperopic
Presbyopes. Adam J. Roy1, A. J. Lang1, T. Porter1,
K. Holliday1, G. Sharma1, A. Chayet2, E. Favela1,
E. Barragan3, S. Gomez3. 1R & D, ReVision Optics,
Inc., Lake Forest, CA; 2Codet Vision Institute,
Tijuana, Mexico; 3Laser Ocular Hidalgo, Monterrey,
Mexico *CR
3130 — D0065 Near Functional Range of
a Near Center Hydrogel Corneal Inlay in
Presbyopic Subjects. Alan J. Lang1, A. J. Roy1,
K. Holliday1, T. Porter1, G. Sharma1, A. Chayet2,
E. Favela1, E. Barragan3, S. Gomez3. 1R & D,
ReVision Optics, Lake Forest, CA; 2Codet Vision
Institute, Tijuana, Mexico; 3Laser Ocular Hidalgo,
Monterrey, Mexico *CR
3131 — D0066 Longer-term Stability of
Refractive Corneal Lenticule Extraction
Procedures Compared with LASIK. Jesper
Hjortdal, I. Bach Pedersen, A. Ivarsen.
Ophthalmology, Aarhus University Hospital,
Aarhus, Denmark *CR
3132 — D0067 Modeling of Human Refractions
for Refractive Surgery. Guang-ming G. Dai. R &
D, Abbott Medical Optics, Milpitas, CA *CR
3136 — D0071 Comparing the Corneal
Biomechanical Stability after LASIK, ReLEx
FLEx and ReLEx SMILE with Ultra High Speed
Camera (Corvis® ST). Iben Bach Pedersen, S. BakNielsen, A. Ivarsen, J. Hjortdal. Ophthalmology,
Aarhus University Hospital, Aarhus, Denmark *CR
3137 — D0072 Femtosecond (FS) Laser
Techniques to Facilitate Deep Anterior Lamellar
Keratoplasty (DALK). Perry S. Binder1, 2, R.
F. Steinert1, 2, J. E. Hill2, M. A. Campos2. 1Gavin
Herbert Dept of Ophthal, Univ of California, Irvine
CA, San Diego, CA; 2Abbott Medical Optics Inc.,
Santa Ana, CA *CR
3138 — D0073 Refractive surgery evaluation
and risk of corneal ectasia, inter-rater agreement
and comparison to a new software: the SCORE
analyzer. Florence Cabot1, S. H. Yoo1, A. Saad2, G.
Kymionis3, A. Canto1, D. Gatinel2. 1Ophthalmology,
Bascom Palmer Eye Institute, Miami, FL;
2
Ophthalmology, Rothschild Foundation, Paris,
France; 3Ophthalmology, University of Crete,
Heraklion, Greece *CR
3139 — D0074 The effect of high order
aberrations on the accuracy of wavefront
ablations using LASEK on high myopes. Jeff
G. Grigsby1, 3, K. Vasquez3, M. Tschoepe4, 3, T.
R. Walters5, 3, B. Cook2, R. G. Sheets2, D. K.
Neely2. 1Redwine Research, LLC, Midland, TX;
2
VisionHealth Specialties, Midland, TX; 3Eye
LASIK Midland, Midland, TX; 4RealEyes Vision
Center, New Braunfels, TX; 5Eye LASIK Austin,
Austin, TX
3140 — D0075 Monocular refractive surgery
in patients with anisometropia. Alejandro Tamez,
J. C. Hernandez-Camarena, J. F. Lozano-Ramirez,
G. Mendoza, A. Rodriguez Garcia, J. E. Valdez.
Tecnologico de Monterrey, Monterrey, Mexico
3141 — D0076 One Year Quality of Vision
Outcomes from a Prospective, Randomized
Eye-to-Eye Comparison of Wavefront guided
and Wavefront optimized Laser in Situ
Keratomileusis (LASIK) using the WaveLight®
Allegretto Eye-Q 400 Hz. Christopher Sáles, E. E.
Manche. Ophthalmology, Stanford, Palo Alto, CA
*CR, f
3142 — D0077 Tear menisci and corneal
subbasal nerve density in patients after Laser
In Situ Keratomileusis. Liang Hu, W. Xie, D.
Zhang, J. Chen, F. Lu. School of Optometry
& Ophthalmology, Wenzhou Medical College,
Wenzhou, China
3143 — D0078 Microkeratome-related
complications in the first 10,000 lasik. Marcos
Garcia1, B. Barth1, 3, W. Nosé2, B. M. Azevedo3, G.
Victor1, M. R. Alves1. 1Ophthalmology, University
of Sao Paulo, Sao Paulo, Brazil; 2Ophthalmology,
Federal University of Sao Paulo, Sao Paulo, Brazil;
3
Potiguar University, Natal, Brazil
3144 — D0079 Laser in situ keratomileusis
following the implantation of an angle-supported
phakic intraocular lens. Cristina Fernandez-Vigo
Escribano1, A. Macarro Merino2, J. FernándezVigo3, J. Fernández-Vigo López2. 1Centro de
Oftalmologia Barraquer, Barcelona, Spain; 2Cioa
Universidad de Extremadura, Badajoz, Spain;
3
Hospital Clinico San Carlos, Madrid, Spain
3145 — D0080 Identification of
microorganisms in water samples used in
refractive surgery facilities. Francisco B. Silva1,
C. V. Niero4, C. L. Nogueira2, C. P. Uzam4, J.
D. Lima Junior2, F. P. Pinto3, A. O. Machado3,
S. C. Leão2, D. Freitas1, A. Hofling-Lima1.
1
Ophthalmology, Federal University of São Paulo,
São Paulo, Brazil; 2Microbiology, Imunology and
Parasitology, Federal University of São Paulo,
São Paulo, Brazil; 3Central laboratory, São Paulo
Hospital, São Paulo, Brazil; 4Biology Sciences,
Diadema Campus, Federal University of São Paulo,
São Paulo, Brazil *CR
3146 — D0081 Comparison of Optical Quality
in Low Myopic and Moderate Myopic Patients
Operated With PRK and FemtoLASIK. Eric
Perez-Campagne, H. Landoulsi, D. Gatinel.
Cataract & Refractive Surgery, Rothschild
Foundation, Paris, France *CR
3147 — D0082 Comparative Effect of corneal
curvature on acurracy of Intraocular Lens
Power Calculation in various fomulars. Bo
Hyuck Kim, M. Kim, W. Wee. ophthalmology, Seoul
National university of Hospital, Seoul, Republic of
Korea
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
216
Tuesday Business Meeting
615-617
Tuesday, May 07, 2013 10:15 AM-10:55 AM
324 General Business Meeting
Agenda TBD
Tuesday Business
Meeting
10:15 am – 10:55 am
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
217
3148 – 3162 – Tuesday – Papers/Minisymposium
6A
6B
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Biochemistry/Molecular Biology / Biochemistry/
Molecular Biology
Glaucoma
325 Biochemical and Molecular
Mechanisms of Diabetic and
Retinal Disease
Moderators: Zsolt Ablonczy and Terri L. Young
Tuesday Papers/
Minisymposium
11:00 am – 12:45 pm
3148 — 11:00 Analysis of extracellular vesicles
in vitreous samples. Bence Gyorgy1, 2, Z. Récsán2.
Kittel3, K. Pálóczi1, L. Turiák4, K. Vékey4, J.
Nemeth2, E. I. Buzas1, Z. Nagy2. 1Department of
Genetics, Cell- and Immunobiology, Semmelweis
University, Budapest, Hungary; 2Department of
Ophthalmology, Semmelweis University, Budapest,
Hungary; 3Institute of Experimental Medicine,
Hungarian Academy of Sciences, Budapest,
Hungary; 4Chemical Research Center, Hungarian
Academy of Sciences, Budapest, Hungary
3149 — 11:15 Nephrocystin-5 knockout mice
recapitulate retina and kidney pathologies of
Senior-Løken Syndrome. Cecinio Ronquillo, J.
M. Frederick, W. Baehr. Ophthalmology and Visual
Sciences, Moran Eye Center, University of Utah,
Salt Lake City, UT
3150 — 11:30 Long-term preservation of
immature cone-like photoreceptors in a mouse
model of human LCA caused by dominant CRX
frameshift mutation. Jerome E. Roger1, A. H.
Hiriyanna1, D. F. Cheng1, N. Gotoh1, R. Priya1, M.
Brooks1, H. K. Rajasimha1, B. Chang2, A. Swaroop1.
1
Neurobiol-Neurodegnt’n Rep Lab, NEI / National
Institutes of Health, Bethesda, MD; 2The Jackson
Laboratory, Bar Harbor, ME *CR
3151 — 11:45 Natriuretic peptides regulate
MAP kinases via PKG to protect the RPE from
VEGF action. Zsolt Ablonczy1, M. Dahrouj1,
Y. Liu1, K. Sambamurti2, C. E. Crosson1.
1
Ophthalmology, Medical University of South
Carolina, Charleston, SC; 2Ophthalmology, Medical
University of South Carolina, Charleston, SC *CR
3152 — 12:00 Restoration of vitreous structure
after degradation. Ying-Bo Shui1, B. Filas1, Q.
Zhang1, S. Sharma3, A. Panitch3, D. C. Beebe1, 2.
1
Dept of Ophthalmology and Visual Sciences,
Washington Univ Sch of Med, St Louis, MO; 2Dept
of Cell Biology and Physiology, Washington Univ
Sch of Med, St Louis, MO; 3Weldon School of
Biomedical Engineering, Purdue University, West
Lafayette, IN *CR
3153 — 12:15 Insulin Stimulates Increased
Production of Soluble Betacellulin in Retinal
Pigment Epithelium Cells. Bailey Y. Shen, M. Ali,
A. Cutler, B. Anand-Apte. Ophthalmology, Cole Eye
Institute, Cleveland Clinic, Cleveland, OH *CR
326 Biomechanics
Moderators: Julie Albon, Mark R. Lesk and John
G. Flanagan
3154 — 11:00 Temporal Relationships in
Structural Changes of the Optic Nerve Head
and Macula in Experimental Glaucoma in NonHuman Primates. Nimesh B. Patel, R. S. Harwerth.
College of Optometry, University of Houston,
Houston, TX
3155 — 11:15 Racial variation in the structure
of the lamina cribrosa and sclera within 3-D
fluorescent reconstructed optic nerve heads
(ONH) from normal human donor tissue.
Christopher A. Girkin1, M. A. Fazio1, H. Yang2, L.
Wang1, B. Smith1, C. C. Cheetham1, C. F. Burgoyne2,
J. C. Downs1. 1Ophthalmology, Univ of Alabama
at Birmingham, Birmingham, AL; 2Devers Eye
Institute, Portland, OR *CR
3156 — 11:30 Racial Differences in Mechanical
Strain in the Posterior Human Sclera. Massimo
A. Fazio1, 2, R. Grytz1, L. Bruno2, J. S. Morris3,
C. A. Girkin2, J. C. Downs2. 1Ophthalmology,
The University of Alabama in Birmingham,
Birmingham, AL; 2Mechanical Engineering,
University of Calabria, Cosenza, Italy; 3Department
of Biostatistics, The University of Texas MD
Anderson Cancer Center, Houston, TX *CR
3157 — 11:45 Peripapillary Sclera (ppS) and
Lamina Cribrosa (LC) 3D Strain Mapping in
High- and Normal-tension Glaucoma Patients
following IOP Lowering by Trabeculectomy
(TE). Michael J. Girard1, 2, N. G. Strouthidis3, 2.
1
Bioengineering, National University of Singapore,
Singapore, Singapore; 2Singapore Eye Research
Institute, Singapore, Singapore; 3Glaucoma
Research Unit, NIHR Biomedical Research Centre
at Moorfields Eye Hospital NHS Foundation Trust
and UCL Institute of Ophthalmology, London,
United Kingdom
3158 — 12:00 IOP Elevation Reduces the
Waviness of the Load Bearing Collagen Fibers
in the Lamina Cribrosa. Ian A. Sigal1, 2, J. L.
Grimm1, N. Jan1, 2, R. A. Bilonick1, 3, G. Wollstein1,
4
, L. Kagemann1, 2, H. Ishikawa1, 2, J. S. Schuman1, 2,
K. A. Davoli1, K. L. Lathrop1, 2. 1Ophthalmology,
University of Pittsburgh, Pittsburgh, PA;
2
Bioengineering, University of Pittsburgh,
Pittsburgh, PA; 3Biostatistics, University of
Pittsburgh, Pittsburgh, PA; 4McGowan Institute for
Regenerative Medicine, University of Pittsburgh,
Pittsburgh, PA *CR
3159 — 12:15 IOP Exposure Determines
Scleral Shell Strain Changes in Nonhuman
Primate (NHP) Experimental Glaucoma. J
Crawford C. Downs1, M. A. Fazio1, M. J. Girard2,
C. F. Burgoyne3. 1Ophthalmology, University
of Alabama at Birmingham, Birmingham, AL;
2
Bioengineering, National University of Singapore,
Singapore, Singapore; 3Devers Eye Institute,
Legacy Research Institute, Portland, OR *CR
3160 — 12:30 Optic Nerve Head (ONH)
Lamina Cribrosa Insertion Migration and
Pialization in Moderate and Severe Non-human
Primate (NHP) Experimental Glaucoma (EG).
Hongli Yang1, R. Ren1, G. Williams1, H. Lockwood1,
J. C. Downs2, S. K. Gardiner1, C. F. Burgoyne1.
1
Discoveries in Sight Research Laboratories, Devers
Eye Institute and the Legacy Research Institute,
Portland, OR; 2Ophthalmology, University of
Alabama at Birmingham, Birmingham, AL *CR
6C
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Retina
327 Imaging: Advances in Imaging
and Diagnostic
Moderators: Ursula Schmidt-Erfurth and
Michael D. Abramoff
3161 — 11:00 In Vivo Choroidal Microvasculature Imaging by High-penetration
Optical Coherence Angiography. Kazuhiro
Kurokawa, Y. Hong, S. Makita, Y. Yasuno.
Computational Optics Group, Tsukuba, Japan *CR
3162 — 11:15 Posterior Pole Choroidal
Vasculature (CV) Assessed By Automated
Choroidal Vessel Segmentation In Standard
Clinical Spectral-Domain Optical Coherence
Tomography (SD-OCT) In Patients With
Diabetic Macular Edema (DME). Bianca S.
Gerendas1, S. M. Waldstein1, B. Haj Najeeb1,
L. Zhang2, H. Bogunovic2, M. D. Abramoff3, 4,
C. Simader1, M. Sonka2, 3, U. Schmidt-Erfurth1.
1
Ophthalmology & Optometry, Medical University
of Vienna, Vienna, Austria; 2Electrical and
Computer Engineering, University of Iowa, Iowa
City, IA; 3Ophthalmology & Visual Sciences,
University of Iowa, Iowa City, IA; 4Department of
Veterans Affairs, Iowa City Veterans Administration
Medical Center, Iowa City, IA *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
218
Tuesday – Papers/Minisymposium – 3163 – 3176
3163 — 11:30 Nonmydriatic Ultrawide Field
Retinal Imaging Reduces Ungradable Rate,
Increases Retinopathy Detection and Reduces
Image Evaluation Time in an Ocular Telehealth
Program for Diabetic Retinopathy. Ahmed F.
Omar1, 3, P. S. Silva1, 2, J. Cavallerano1, 2, K. Hock1,
A. M. Tolson1, N. Haddad1, J. K. Sun1, 2, L. M.
Aiello1, 2, L. P. Aiello1, 2. 1Beetham Eye Institute,
Joslin Diabetes Center, Boston, MA; 2Department of
Ophthalmology, Harvard Medical School, Boston,
MA; 3Department of Ophthalmology, Faculty of
Medicine, Assiut University, Assiut, Egypt *CR
3164 — 11:45 Ultra-Widefield Fundus
Autofluorescence Imaging in Central Serous
Chorioretinopathy. Vinnie P. Shah1, 2, D. Sarraf3,
K. Freund1, 2. 1Vitreous, Retina, Macula Consultants
of New York, New York, NY; 2New York University
School of Medicine Department of Ophthalmology,
New York, NY; 3Jules Stein Eye Institute, UCLA,
Los Angeles, CA *CR
3166 — 12:15 Polarimetric imaging of
geographic atrophy in age-related macular
degeneration by polarization sensitive SLO
and OCT. Masahiro Miura1, A. E. Elsner2, Y.
Hong3, T. Iwasaki1, S. Makita3, Y. Yasuno3. 1Dept
of Ophthalmology, Tokyo Med Univ, Ibaraki Med
Ctr, Inashiki, Japan; 2School of Optometry, Indiana
University, Bloomington, IN; 3COG, Univ of
Tsukuba, Tsukuba, Japan *CR
3167 — 12:30 Enhanced Vitreal Imaging
of the Vitreoretinal Interface in Normal Eyes
Using Swept-Source OCT. Jonathan J. Liu1, A.
J. Witkin2, M. Adhi2, I. Grulkowski1, M. F. Kraus3,
C. D. Lu1, J. M. Hornegger3, J. S. Duker2, J. G.
Fujimoto1. 1Department of Electrical Engineering
and Computer Science and Research Laboratory of
Electronics, Massachusetts Institute of Technology,
Cambridge, MA; 2New England Eye Center, Tufts
Medical Center, Boston, MA; 3Pattern Recognition
Lab and Graduate School in Advanced Optical
Technologies, University of Erlangen-Nuremburg,
Erlangen, Germany *CR
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Retina
328 AMD: Long Term Outcomes and
Safety of Anti VEGF
Moderators: Anat Loewenstein and
Francesco Bandello
3168 — 11:00 Longer Term Safety Outcomes
(4 or More Years) After Initiating Anti-Vascular
Endothelial Growth Factor Therapy for
Neovascular Age-related Macular Degeneration.
Erika Tanaka1, V. Chaikitmongkol2, 3, S. B. Bressler2,
N. M. Bressler2. 1Johns Hopkins University School
of Medicine, Baltimore, MD; 2Retina Division,
Wilmer Eye Institute, Johns Hopkins University,
Baltimore, MD; 3Retina Division, Department of
Ophthalmology, Chiang Mai University Hospital,
Chiang Mai, Thailand *CR
3169 — 11:15 Aqueous Vascular
Endothelial Growth Factor and Ranibizumab
Concentrations after Monthly and Bimonthly
Intravitreal Injections of Ranibizumab for AgeRelated Macular Degeneration. Xiying Wang1, 2, T.
Sawada1, M. Kakinoki1, T. Miyake3, H. Kawamura1,
Y. Saishin1, P. Liu2, M. Ohji1. 1Ophthalmology
Department., Shiga University of Medical Science,
Otsu, Japan; 2Ophthalmology, Eye Hospital, First
Affiliated Hospital,Harbin Medical University,
Harbin, China; 3Ophthalmology, Kohka Public
Hospital, Kohka, Japan *CR, f
3170 — 11:30 Detection of anti-ranibizumab
antibodies among exudative AMD patients.
Nicolas Leveziel1, 5, T. Pelat2, H. Watier3, P.
Thullier4, E. H. Souied5. 1Ophthalmology, Poitiers
University Hospital, Poitiers, France; 2DBAT/
Biotechnologies des anticorps, Centre de Recherche
du Service de Santé des Armées, La Tronche,
France; 3Pilot centre for Therapeutic Antibody
Monitoring, Université François-Rabelais de Tours,
CNRS UMR 7292, CHRU de Tours, Tours, France;
4
DBAT/Biotechnologies des anticorps, Centre de
Recherche du Service de Santé des Armées, La
Tronche, France; 5Ophthalmology, Creteil Eye
University, Creteil, France *CR
3171 — 11:45 Subanalysis of Visual Acuity
Outcomes in the Second Year of VIEW
Studies. Michaella Goldstein1, J. Korobelnik2, C.
Norenberg3, O. Zeitz3. 1Ophthalmology, Tel Aviv
Medical Center, Tel Aviv, Israel; 2Department
of Ophthalmology, CHU Bordeaux, Universite
Bordeaux, Bordeaux, France; 3Bayer Healthcare,
Berlin, Germany *CR, f
3172 — 12:00 Cerebrovascular risk by
intravitreal injections of vascular endothelial
growth factor inhibitors for age-related macular
degeneration: systematic review of literature and
meta-analysis. Takashi Ueta1, Y. Noda1, T. Toyama1,
T. Yamaguchi2. 1Ophthalmology, Univ of Tokyo,
School of Med, Bunkyo-ku, Japan; 2Division of
Biostatistics, Tohoku University Graduate School of
Medicine, Sendai, Japan
3173 — 12:15 Postoperative bacterial
endophthalmitis: tap/inject versus sutureless
vitrectomy. Thomas P. Lindquist1, L. B. Mason2,
J. O. Mason2, J. O. Mason2, G. McGwin1, C.
Huisingh5, D. A. Friedman2, R. E. Morris3, M.
H. Oltmanns3, A. Dinsmore4. 1Ophthalmology,
University of Alabama-Birmingham, Birmingham,
AL; 2Retina Consultants of Alabama, Birmingham,
AL; 3Retina Specialists of Alabama, Birmingham,
AL; 4School of Medicine, University of AlabamaBirmingham, Birmingham, AL; 5University of
Alabama- Birmingham, Birmingham, AL
3174 — 12:30 Changing patterns of
endophthalmitis at a state-wide service in
Australia over a 14 year period. Jonathan K.
Kam1, R. Dawkins1, D. A. Buck1, S. S. Sandhu1, 2, P.
J. Allen1, 2. 1Royal Victorian Eye and Ear Hospital,
Melbourne, VIC, Australia; 2Centre for Eye
Research Australia, Melbourne, VIC, Australia *CR
606/607
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Immunology/Microbiology
329 Inflammatory Tissue Damage
and Immunoregulation
Moderators: Graham R. Wallace and
Eric Pearlman
3175 — 11:00 Dendritic Cell-produced
TSLP Links Microbial Pathogens to Allergic
Inflammation. De-Quan Li1, Z. Su1, 2, L. Zhang1, 3,
J. Lin1, 3, C. S. De Paiva1, S. C. Pflugfelder1.
1
Ophthalmology, Baylor College of Medicine,
Houston, TX; 2School of Optometry and
Ophthalmology, Wenzhou Medical College,
Wenzhou, China; 3Ophthalmology, Qingdao
University Medical College, Qingdao, China *CR
3176 — 11:15 Autoimmune component in
glaucoma: IgG autoantibody accumulation,
plasma cells and microglia under proinflammatory conditions. Oliver W. Gramlich,
S. Beck, A. Ziegler, N. Pfeiffer, F. H. Grus.
Experimental Ophthalmology, Department of
Ophthalmology, University Medical Center, Mainz,
Germany *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
219
Tuesday Papers/
Minisymposium
11:00 am – 12:45 pm
3165 — 12:00 Simultaneous 3D Doppler and
Polarization Imaging of Macular Pathologies
by Polarization-Sensitive Optical Coherence
Angiography. Young-Joo Hong1, 4, M. Miura2, 4,
M. Ju3, 4, S. Makita1, 4, Y. Yasuno1, 4. 1Computational
Optics Group, University of Tsukuba, Tsukuba,
Japan; 2Department of Ophthalmology, Ibaraki
Medical Center, Tokyo Medical University,
Inashiki, Japan; 3Electrical and Computer
Engineering, University of British Columbia,
Vancouver, BC, Canada; 4Computational Optics and
Ophthalmology Group, Tsukuba, Japan *CR
6E
3177 – 3192 – Tuesday – Papers/Minisymposium
3177 — 11:30 Ocular Pathology and
Immunopathology of Blau’s Syndrome: First
Cases. David S. Bardenstein1, A. B. Collins1,
F. Orge1, D. P. Edward4, E. B. Brooks2, D. A.
Goldstein5, R. Bouhenni3, E. Pearlman1, E. I.
Traboulsi6. 1UH Eye Institute, Case-University
Hospitals Medical Center, Cleveland, OH;
2
Medicine, Case University Hospitals Medical
Center, Cleveland, OH; 3Ophthalmology, Summa
Health System, Akron, OH; 4Ophthalmology,
King Khaled Hospital and Wilmer Eye Institute,
Baltimore, MD; 5Ophthalmology & Visual Sciences,
University of Illinois, Chicago, IL; 6Cole Eye
Institute, Cleveland Clinic Foundation, Cleveland,
OH *CR
Tuesday Papers/
Minisymposium
11:00 am – 12:45 pm
3178 — 11:45 Serum Autoantibody Evaluation
after Retinal Laser Injury in Mice. Yannis M.
Paulus1, C. Kuo2, K. Morohoshi2, A. Nugent1, L.
Zheng1, H. Nomoto1, M. S. Blumenkranz1, D. V.
Palanker1, S. Ono2. 1Ophthalmology, Stanford
University, Palo Alto, CA; 2Pediatrics, University of
Cincinnati, Cincinnati, OH *CR
3179 — 12:00 Promoting CD200R
signalling inhibits laser-induced choroidal
neovascularisation due to altered proangiogenic
macrophage gene expression. David A. Copland1,
S. J. Robbie2, J. Liu1, W. Wu1, R. R. Ali2, J. W.
Bainbridge2, A. D. Dick1. 1Ophthalmology, School
of Clinical Sciences, University of Bristol, Bristol,
United Kingdom; 2Genetics, UCL Institute of
Ophthalmology & NIHR Biomedical Research
Centre London, London, United Kingdom *CR
3180 — 12:15 Paradoxical Role of Caveolin-1
in Retinal Inflammation. Michael H. Elliott1, X.
Li2, X. Gu1, A. M. Reagan1, T. M. Boyce1, I. Sluch1,
M. A. Mandal1, M. C. Callegan1, D. J. Carr1.
1
Ophthalmology, OUHSC, Oklahoma City, OK;
2
Key Laboratory of Medical Cell Biology, China
Medical University, Shengyan, China
3181 — 12:30 Minocycline Prevents
Inflammatory Leukocyte Infiltration Following
Retinal Ischemia-Reperfusion Injury. Steven
F. Abcouwer1, S. Shanmugam1, C. Lin1, H.
Lindner1, A. J. Barber2, A. Muthusamy1, D. A.
Antonetti1. 1Ophthalmology & Visual Sciences,
Univ of Michigan Kellog Eye Ctr, Ann Arbor,
MI; 2Ophthalmology, Penn State Hershey Medical
Center, Hershey, PA
608
609
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Anatomy/Pathology
Lens
330 From Cytology to Proteomics: New
Insights into the Vitreous and Its Role
in Ocular Disease - Minisymposium
331 Lens Development
Increasing awareness of the importance of vitreous
in ocular development and disease has inspired
innovative research. As a result, major strides in our
understanding of vitreous ultrastructure, histology
and composition have been made in the past decade.
This mini-symposium will illuminate the recent
advances in vitreous and vitreoretinal research,
including proteomics, exosomes, and vitreoretinal
interface, and describe how these advances translate
into clinical practice.
3189 — 11:00 Lysine Acetyltransferases CBP
and EP300 are Essential for Histone H3 K18
and K27 Acetylation in the Lens Placode and to
Determine the Fate of Lens Progenitor Cells. Ales
Cvekl1, L. V. Wolf1, W. R. Harrison2, Y. Liu3, Q. Xie1,
V. Govindarajan4, S. A. Lachke5, R. Ashery-Padan6,
D. C. Beebe3, P. A. Overbeek2. 1Ophthalmology
& Vis Sci & Genetics, Albert Einstein Coll of
Medicine, Bronx, NY; 2Molecular and Cellular
Biology, Baylor College of Medicine, Houston, TX;
3
Ophthalmology and Visual Sciences, Washington
University St. Louis, St. Louis, MO; 4Surgery,
Creighton University, Omaha, NE; 5Biological
Sciences, University of Delaware, Newark, DE;
6
Human Molecular Genetics and Biochemistry, Tel
Aviv University Sackler School of Medicine, Tel
Aviv, Israel *CR
Moderators: Tatyana Milman, Richard B. Rosen
and David J. Wilson
— 11:00 Introduction
3182 — 11:02 Hyalocytes in Ocular
Development and Disease. Paul G. McMenamin.
Dept of Anatomy & Dev Biology, Monash
University, Melbourne, VIC, Australia
3183 — 11:16 Proteomics of Embryonic
Human Vitreous Development. Lloyd P. Aiello.
Ophthalmology-Eye Res, Joslin Diabetes Center,
Boston, MA *CR
3184 — 11:30 Role of Exosomes in
Aqueous Humor Dynamics. W Daniel Stamer.
Ophthalmology, Duke University, Durham, NC *CR
3185 — 11:44 Identification of Protein
Biomarkers in Vitreous Humor Following Laser
Exposure. Rachida Bouhenni. Ophthalmology,
Summa-Health System, Akron, OH
3186 — 11:58 Advances in Understanding
and Treatment of Diabetic Retinopathy from
Vitreous Studies. Elia J. Duh. Ophthalmology,
Johns Hopkins Wilmer Eye Inst, Baltimore, MD
3187 — 12:12 Anomalous PVD and
Pharmacologic Vitreolysis. J. Sebag. VMR
Institute, Univ of Southern California, Huntington
Beach, CA *CR
3188 — 12:26 Proliferative Vitreoretinopathy:
Od Problem, New Treatments. Andrius
Kazlauskas. Ophthalmology, Schepens Eye Res
Inst/ Harvard, Boston, MA
— 12:40 Discussion
Moderators: Melinda K. Duncan and
Michael L. Robinson
3190 — 11:15 Restricted period of Smoothened
requirement during lens development. Robbert
De Iongh, C. Ting, J. Choi, G. Martinez. Anatomy
& Neuroscience, University of Melbourne,
Parkville, VIC, Australia
3191 — 11:30 Identification of small MAF
family transcription factors MafG and MafK
associated with cataract. Salil A. Lachke1, 2,
S. Agrawal1, A. Kakrana3, C. A. Dang1, S. M.
Waters1, A. Singh4, 2, H. Motohashi5. 1Department
of Biological Sciences, University of Delaware,
Newark, DE; 2Center for Bioinformatics and
Computational Biology, University of Delaware,
Newark, DE; 3Department of Plant and Soil
Sciences, University of Delaware, Newark, DE;
4
Department of Electrical Engineering, University
of Delaware, Newark, DE; 5Graduate School of
Medicine, Tohoku University, Sendai, Japan
3192 — 11:45 SUMO-Conjugated RanGAP1 Is
A Major Lens Protein Regulating MAP Kinase
Pathway and MicroRNA Distribution. David W.
Li1, 2, W. Ji1, X. Hu1, 3, W. Hu1, 3, F. Liu2, X. Tang2,
K. Wu2, Y. Liu2, L. Gong1, M. Deng1. 1Biochemistry
& Molecular Biology, University of Nebraska
Medical Center, Omaha, NE; 2State Key Laboratory
of Zhongshan Ophthalmic Center, Sun Yat-sen
University, Guangzhou, China; 3Key Laboratory
of Protein Chemistry and Developmental Biology,
College of Life Science, Hunan Normal University,
Changsha, China
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
220
Tuesday – Papers/Minisymposium – 3193 – 3212
3193 — 12:00 Double deficiency of Rap1A and
B reveals a crucial role for Rap1 in cell adhesive
interactions and cell survival, plasticity, polarity
and migration events during lens morphogenesis.
Tharkika Nagendran1, R. Maddala1, V. Rao1, 2.
1
Ophthalomology, Duke University School of
Medicine, Durham, NC; 2Pharmacology and Cancer
Biology, Duke University School of Medicine,
Durham, NC
3194 — 12:15 Loss of βA3/A1-crystallin alters
normal remodeling of the hyaloid vasculature.
Debasish Sinha1, M. Valapala1, J. S. Zigler1, G. A.
Lutty1, E. F. Wawrousek2, L. Dong2, S. L. Hose1.
1
Ophthalmology, Johns Hopkins Wilmer Eye Inst,
Baltimore, MD; 2National Eye Institute, National
Institutes of Health, Bethesda, MD
3195 — 12:30 β1-integrin may be a direct
regulator of EGR1 (Early Growth Response 1)
within the lens. Anne M. Terrell, M. K. Duncan.
Biological Sciences, University of Delaware,
Newark, DE
611-614
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Retinal Cell Biology
Moderators: Christine A. Curcio and
James T. Handa
3196 — 11:00 Human choroidal thickness:
Relationship to protease inhibitors. Robert F.
Mullins1, A. Khanna1, K. Wang2, M. J. Riker1,
E. M. Stone1, E. H. Sohn1. 1Ophthalmology and
Visual Sciences, University of Iowa, Iowa City, IA;
2
Biostatistics, University of Iowa, Iowa City, IA
*CR
3197 — 11:15 Metabolic impact of cigarette
smoke on RPE and Müller cells of complement
compromised mice. Alexandra D. Butler1, W. D.
Ferrell1, A. S. Woodell2, B. Rohrer2, R. E. Marc1, B.
W. Jones1. 1Ophthalmology, Moran Eye Center, Salt
Lake City, UT; 2Ophthalmology, Med Univ of South
Carolina, Charleston, SC *CR
3198 — 11:30 Cigarette smoke and RPE
injury: role of oxidative stress and ER stress.
Chuangxin Huang, J. J. Wang, S. X. Zhang.
Department of Ophthalmology, Ross Eye Institute,
University at Buffalo, State University of New
York, Buffalo, NY
3199 — 11:45 Biometrics and Impact of Basal
Linear Deposit (BlinD) in Aging and NonNeovascular Age-Related Macular Degeneration
(nnAMD). Christine A. Curcio1, J. D. Messinger2,
N. E. Medeiros3, G. McGwin4. 1Ophthalmology,
Univ of Alabama at Birmingham, Birmingham, AL;
2
Ophthalmology, Univ of Alabama at Birmingham,
Birmingham, AL; 3Retina Specialists of North
Alabama, Huntsville, AL; 4Epidemiology, Univ of
Alabama at Birmingham, Birmingham, AL
3206 — 11:45 Noninvasive Dexamethasone
Sodium Phosphate Ocular Drug Delivery System
for the Treatment of Intermediate and Posterior
Uveitis. Kongnara Papangkorn1, 2, D. Mix1, C.
Butler1, J. Higuchi1, B. Brar1, W. I. Higuchi2, 1.
1
Aciont Inc, Salt Lake City, UT; 2University of
Utah, Salt Lake City, UT *CR
3201 — 12:15 In Vivo Imaging of RNA
Biomarkers in Choroidal Neovascularization.
Ashwath Jayagopal, C. Moore. Vanderbilt Eye
Institute, Vanderbilt University Medical Center,
Nashville, TN
3207 — 12:00 Ocular Delivery of the Novel
Spleen Tyrosine Kinase Inhibitor R406 for
Retinoblastoma. Eleanor M. Pritchard1, 2, F. Zhu1,
L. Yang1, C. Bradley2, E. Stewart3, 2, J. Zhang2,
B. B. Freeman4, M. Dyer2, 5, R. Guy1. 1Chemical
Biology and Therapeutics, St. Jude Children’s
Research Hospital, Memphis, TN; 2Developmental
Neurobiology, St. Jude Children’s Research
Hospital, Memphis, TN; 3Hematology/Oncology,
St. Jude Children’s Research Hospital, Memphis,
TN; 4Pharmaceutical Sciences, St. Jude Children’s
Research Hospital, Memphis, TN; 5Ophthalmology,
University of Tennessee Health Sciences Center,
Memphis, TN
3202 — 12:30 C1q and Wnt Pathway
Expression in Geographic Atrophy Model of
ApoB100 Mutant Mice. Katayoon B. Ebrahimi, S.
E. Dike, C. Gutierez, J. T. Handa. Ophthalmology,
Johns Hopkins University, Baltimore, MD *CR
618-620
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Physiology/Pharmacology
333 Drug Delivery II
Moderators: Haiyan Gong and Uday B. Kompella
3203 — 11:00 Deslorelin and transferrin
mono- and dual- functionalized nanomicelles
for drug delivery to the anterior segment of the
eye. Trivedi Ruchit1, P. Tyagi1, S. K. Vooturi1, U. B.
Kompella1, 2. 1Pharmaceutical sciences, University
of Colorado Anschutz Medical Campus, Aurora,
CO; 2Ophthalmology, University of Colorado
Anschutz Medical Campus, Aurora, CO *CR
3204 — 11:15 The Influence of Formulation
Factors on Transscleral Iontophoretic Delivery of
a Macromolecule in Vitro and in Vivo. Sarah A.
Molokhia1, 2, K. Papangkorn1, C. Butler1, D. Mix1, J.
Higuchi1, B. Brar1, S. Li3, W. I. Higuchi1, 4. 1Aciont
Inc, Salt Lake City, UT; 2Ophthalmology, Moran
Eye Center, University of Utah, Salt Lake City, UT;
3
College of Pharmacy, University of Cincinnati,
Cincinnati, OH; 4College of Pharmacy, University
of Utah, Salt Lake City, UT *CR
3205 — 11:30 Versatile time-release technology
reducing frequency of invasive injections in
treating retinal diseases. Chi-Chun Lai1, 3, L.
Yeung2, 3, L. Chuang2, 3, Y. Hwang1, 3, C. Tsai4, P.
Chang4, L. Guo4, 5, Y. Tseng4, S. Shih4, K. Hong4, 5.
1
Ophthalmology, Chang Gung Memorial Hospital Kaohsiung, Kwei-Shan, Taiwan; 2Ophthalmology,
Chang Gung Memorial Hospital, Keelung, Taiwan;
3
Chang Gung University College of Medicine,
Kwei-Shan, Taiwan; 4Taiwan Liposome Company,
Taipei, Taiwan; 5TLC Biopharmaceutical, Inc.,
California, CA *CR
3208 — 12:15 Intravitreal long-lasting micelle
formulation of hexadecyloxypropyl-cidofovir
(HDP-CDV) for cytomegalovirus retinitis. Feiyan
Ma1, S. Lee1, H. Hou1, J. Beadle2, W. R. Freeman1,
K. Hostetler2, L. Cheng1. 1Ophthalmology, Shiley
Eye Center, UCSD, La Jolla, CA; 2Department of
Medicine, San Diego VA Healthcare System and
UC San Diego, LA JOLLA, CA *CR
3209 — 12:30 Characterization of the In
Vitro Release Kinetics of Bevacizumab from a
Biocompatible Reverse Thermal Gel. Britta M.
Rauck1, C. A. Medina-Mendez2, T. R. Friberg2, Y.
Wang1. 1Bioengineering, University of Pittsburgh,
Pittsburgh, PA; 2Ophthalmology, University of
Pittsburgh Medical Center, Pittsburgh, PA *CR
TCC LL 4/5
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Visual Psychophysics / Physiological Optics / Eye
Movements / Strabismus / Amblyopia / NeuroOphthalmology / Glaucoma
334 Clinical Aspects of Motion
Perception - Minisymposium
This session provides a comprehensive overview
of recent advances in the understanding of motion
perception in ocular disease and visual dysfunction.
Moderators: Peter Bex and Rigmor C. Baraas
3210 — 11:00 Motion perception in ocular
disease and visual dysfunction. Peter Bex.
Harvard Medical School, Boston, MA *CR
3211 — 11:15 Motion perception in migraine.
Allison M. McKendrick. Optometry & Vision
Sciences, The University of Melbourne, Parkville,
VIC, Australia *CR
3212 — 11:30 Motion Perimetry. Michael Wall.
Neurology & Ophthalmology, Univ of Iowa, Carver
Coll of Med, Iowa City, IA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
221
Tuesday Papers/
Minisymposium
11:00 am – 12:45 pm
332 Risks Associated with AMD
3200 — 12:00 Egg or hen: Use of combined
light and electron microscopy to reveal
whether CC breakdown precedes RPE
degeneration in AMD. Antje K. Biesemeier,
T. Taubitz, U. Schraermeyer. Section of
Experimental Vitreoretinal Surgery, Department of
Ophthalmology, Tuebingen, Germany *CR
3213 – 3233 – Tuesday – Papers/Minisymposium
3213 — 11:45 Moorfields Motion Displacement
Test for Glaucoma. David F. Garway-Heath.
Institute of Ophthalmology, University College
London, London, United Kingdom *CR
3214 — 12:00 Global motion, suppression and
amblyopia. Robert F. Hess. Ophthalmology, McGill
University, Montreal, QC, Canada
3215 — 12:15 Peripheral Motion Perception in
Low Vision: Characterization of Deficits and the
Effects of Training. Duje Tadin. Brain & Cognitive
Science, University of Rochester, Rochester, NY
3216 — 12:30 Motion Perception in
Nystagmus. Magella M. Neveu. Electrophysiology,
Moorfields Eye Hospital, London, United Kingdom
TCC 303
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Tuesday Papers/
Minisymposium
11:00 am – 12:45 pm
Cornea
3222 — 12:15 3-Dimensional Assessment of In
Vivo Corneal Wound Healing using a Modified
HRT-RCM Confocal Microscope. Matthew
Petroll1, 3, D. B. Hagenasr2, H. D. Cavanagh1,
D. M. Robertson1. 1Ophthalmology, Univ Texas
Southwestern Med Ctr, Dallas, TX; 2Molecular and
Cell Biology, Univ Texas at Dallas, Dallas, TX;
3
Biomedical Engineering, Univ Texas Southwestern
Med Ctr, Dallas, TX *CR
3223 — 12:30 Optical coherence tomography
(OCT) combined with videokeratography to
detect ‘early’ keratoconus - a new “pachymetry/
asymmetry” index to quantify disease severity.
Yaron S. Rabinowitz, Y. Bykhovskaya, X. Li, A. C.
Canedo. Cornea Genetic Eye Institute, Beverly
Hills, CA
TCC 304
Tuesday, May 07, 2013 11:00 AM-12:45 PM
335 Corneal Epithelium and
Imaging III
Cornea
Moderators: Roger W. Beuerman and
Matthew Petroll
Moderator: Rajiv R. Mohan
3217 — 11:00 Binding of transmembrane
mucins to galectin-3 limits herpes simplex
virus infection. Pablo Argueso, J. Mauris, A.
M. Woodward. Schepens Eye Research Institute
and Massachusetts Eye and Ear, Dept. of
Ophthalmology, Harvard Medical School, Boston,
MA
3218 — 11:15 Identification and Validation
of PNN-regulated Splicing Events in Human
Corneal Epithelial Cells. Stephen P. Sugrue,
J. Joo. Anatomy & Cell Biology, University of
Florida, Gainesville, FL
3219 — 11:30 Suture placement on the mouse
cornea induces K8 and Muc5ac expression
within K12+ corneal epithelial cells. Mary
Ann Stepp1, G. Tadvalkar1, V. L. Perez4, Y. Tan4,
S. Ghosh1, J. D. Zieske3, A. Lee2, V. E. TrinkausRandall2, A. Pajoohesh-Ganji1. 1Anatomy &
Regenerative Biology, George Washington
University, Washington, DC; 2Biochemistry, Boston
University School of Medicine, Boston, MA;
3
Ophthalmology, Harvard/Schepen’s Eye Research
Institute, Boston, MA; 4Ophthalmology, Bascom
Palmer Eye Institute, Miami, FL *CR
3220 — 11:45 Corneal Confocal Microscopy
detects neuropathy before retinopathy and
nephropathy in children with Type 1 Diabetes:
A Preliminary Study. Mitra Tavakoli, R. A. Malik.
Centre for Endocrinology & Diabetes, Institute of
Human Development, University of Manchester,
Manchester, United Kingdom
3221 — 12:00 The Role of Epithelial
Remodeling on Refractive Regression after
Femtosecond LASIK. Karolinne M. Rocha, R. R.
Krueger. Ophthalmology, Cleveland Clinic - Cole
Eye Institute, Cleveland, OH *CR
336 Cell and Molecular Biology
3224 — 11:00 Cellular cross-talk in the
limbal epithelial stem cell niche revealed by
high-resolution microscopy. Julie T. Daniels1,
H. Armer1, H. J. Levis1, P. M. Munro1, A. J.
Shortt2, S. J. Tuft2, M. Dziasko1. 1Ocular Biology
& Therapeutics, UCL Institute of Ophthalmology,
London, United Kingdom; 2NIHR Biomedical
Research Centre, Moorfields Eye Hospital
NHS Foundation Trust and the UCL Institute of
Ophthalmology, London, United Kingdom
3225 — 11:15 Pluripotency marker TRA1-60 is expressed in stromal, perivascular
and intraepithelial cells at the human limbus.
Friedrich E. Kruse, N. Polisetti, J. MenzelSevering, U. Schlotzer-Schrehardt. Department of
Ophthalmology, University of Erlangen Nurnberg,
Erlangen, Germany
3226 — 11:30 Donor MSCs expressing MHC
class II molecule trigger immune responses in
an animal model of lacrimal gland chronic graft
versus host disease. Yoko Ogawa, S. Shimmura,
S. Yaguchi, T. Inaba, K. Tsubota. Department of
Ophthalmology, Keio Univ School of Medicine,
Shinjuku-Ku, Japan *CR
3227 — 11:45 Integral Analysis of Gene
Signatures and MicroRNA Expression of
Cultured Human Corneal Endothelial Cells in
Relation to Their Functions, Cell Senescence,
Epithelial-Mesenchymal Transition, and
Fibrosis. Kazuko Asada1, M. Toda1, M. Hagiya1,
K. Nakata1, M. Ueno1, N. Okumura2, N. Koizumi2,
J. Hamuro1, S. Kinoshita1. 1Department of
Ophthalmology, Kyoto Prefectural University of
Medicine, Kyoto, Japan; 2Department of Biomedical
Engineering, Doshisha University, Kyotanabe,
Japan *CR
3228 — 12:00 CXCR4 Expression Marks
Cells in Limbal Stroma with the Potential
to Differentiate to Keratocytes. James L.
Funderburgh, A. Hertsenberg, M. L. Funderburgh,
K. L. Lathrop, Y. Du. Ophthalmology, Univ of
Pittsburgh School of Medicine, Pittsburgh, PA *CR
3229 — 12:15 miRNA Expression Profiling
in Central and Limbal Diabetic and Normal
Human Corneas Using Deep Sequencing.
Mehrnoosh Saghizadeh1, J. Brown2, A.
V. Ljubimov1, 3, V. A. Funari2, 3. 1Surgery/
Ophthalmology, Cedars-Sinai Medical Center,
Los Angeles, CA; 2Genomic Core, Cedars-Sinai
Medical Center, Los Angeles, CA; 33David Geffen
School of Medicine, University of California Los
Angeles, Los Angeles, CA
3230 — 12:30 Standardized cultivation and
transplantation of limbal stem cell grafts: Results
of a phase I/II clinical trial. Nadia Zakaria1, 2, T.
Possemiers1, 2, I. Leysen1, J. J. Rozema1, C. Koppen1,
Z. Berneman2, M. B. Tassignon1. 1Ophthalmology,
Antwerp University Hospital, Antwerp, Belgium;
2
Center for Cell Therapy and Regenerative
Medicine, Antwerp University Hospital, Antwerp,
Belgium *CR, f
TCC 305
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology
337 Neuro-Ophthalmology: Structural
Imaging Studies
Moderators: Mark J. Kupersmith and
Heather E. Moss
3231 — 11:00 Thinning of the Optic Nerve in
Aging and after Ischemia: An Imaging Study
Using Spectral-Domain Optical Coherence
Tomography. M. Ali Shariati, G. Lee, Y. J. Liao.
Ophthalmology, Stanford School of Medicine,
Stanford, CA
3232 — 11:15 Abnormal Optic Nerve
Head Topography in Albinism Imaged Using
High Resolution Spectral Domain-Optical
Coherence Tomography. Frank A. Proudlock, S.
Mohammad, V. Sheth, A. Pilat, H. Lee, I. Gottlob.
Ophthalmology, University of Leicester, Leicester,
United Kingdom
3233 — 11:30 Early Retinal Ganglion Cell
Layer Thinning Due to Acute NAION and Optic
Neuritis. Mark J. Kupersmith1, M. K. Garvin2, 3, J.
Wang2, R. H. Kardon3, 4. 1Neuro-Ophthalmology,
Roosevelt Hospital and NYEE, New York, NY;
2
Electrical and Computer Engineering and Center,
University of Iowa, Iowa City, IA; 3Center of
Excellence for the Prevention and Treatment of
Visual Loss, Department of Veterans Affairs,
Rehabilitation Research and Development Division,
Iowa City, IA; 4Ophthalmology, University of Iowa,
Iowa City, IA *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
222
Tuesday – Papers/Minisymposium – 3234 – 3237
3234 — 11:45 Regional Spectral-Domain
Optical Coherence Tomography Features Better
Predict Frisén Scale Grades than Total Volume
Alone in Papilledema. Jui-Kai Wang1, 3, M. Miri1, 3,
R. H. Kardon2, 3, M. K. Garvin3, 1. 1Electrical &
Computer Eng, University of Iowa, Iowa City, IA;
2
Ophthalmology and Visual Sciences, University of
Iowa, Iowa City, IA; 3Center for the Prevention and
Treatment of Visual Loss, Veterans Administration
Hospital, Iowa City, IA *CR
3235 — 12:00 Structure-Function Relationship
in Optic Nerve Head Drusen. Stephanie J.
Muylaert1, S. Park1, 2, R. L. Furlanetto1, Y. Liu1, 3, C.
F. Netto1, R. Banik2, 4, J. M. Liebmann1, 5, R. Ritch1, 2.
1
Moise and Chella Safra Advanced Ocular Imaging
Laboratory, Einhorn Clinical Research Center,
New York Eye and Ear Infirmary, New York, NY;
2
Department of Ophthalmology, New York Medical
College, Valhalla, NY; 3New York Medical College,
Valhalla, NY; 4Department of Ophthalmology,
New York Eye and Ear Infirmary, New York,
NY; 5Department of Ophthalmology, New York
University School of Medicine, New York, NY *CR
3236 — 12:15 Retinal vessel diameters in
papilledema. Heather E. Moss, G. Treadwell, J.
Wanek, M. Shahidi. Ophthalmology and Visual
Sciences, University of Illinois, Chicago, IL *CR
Tuesday Papers/
Minisymposium
11:00 am – 12:45 pm
3237 — 12:30 Automated quantification
of globe flattening by MRI in Idiopathic
Intracranial Hypertension. Byron L. Lam1, A. M.
Bagci2, N. Alperin2. 1Bascom Palmer Eye Institute,
University of Miami, Miami, FL; 2Radiology,
University of Miami, Miami, FL
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
223
3238 – 3261 – Tuesday – Posters
Exhibit Hall A0029-A0062
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Retinal Cell Biology
338 Retinal Degeneration and
Neuroprotection
Moderator: Ellen Townes-Anderson
3238 — A0029 Interaction between CEP290
and BBSome genes is required for mediating
cilia function in retina. Yan Zhang1, A. V. Drack1,
K. Bugge1, 2, C. Searby1, 2, V. C. Sheffield1, 2, S.
Seo1. 1University of Iowa, Iowa City, IA; 2Howard
Hughes Medical Institute, Chevy Chase, MD
Tuesday Posters
11:00 am – 12:45 pm
3239 — A0030 High-mobility group box-1
induces decreased brain-derived neurotrophic
factor-mediated neuroprotection in the diabetic
retina. Mairaj Siddiquei, M. I. Nawaz, A. Abu ElAsrar. Ophthalmology, College of Medicine, King
Saud University, Riyadh, Saudi Arabia
3240 — A0031 Inhibition of Transforming
Growth Factor β1 (TGF-β1) Using Morpholino
Antisense Promotes Repair in Diabetic CD34+
Cells by Modulating the Protein Ubiquitination
Pathway. Jude Al-Sabah1, V. Stepps2, S. Bartelmez2,
M. B. Grant1, A. D. Bhatwadekar1. 1Department
of Pharmacology and Therapeutics, University of
Florida, Gainesville, FL; 2Beta Stem Therapeutics,
San Francisco, CA *CR
3241 — A0032 Myocyte Enhancer Factor 2C
(MEF2C) suppresses inflammation in retinal
endothelial cells via regulation of KLF2. Zhenhua
Xu1, J. Gong1, T. Yoshida2, L. Wu1, L. Cebotaru1,
E. J. Duh1. 1Wilmer Eye Institute, Johns Hopkins
University, Baltimore, MD; 2Doheny Eye Institute,
Keck School of Medicine of the University of
Southern California, Los Angeles, CA
3242 — A0033 Prorenin Receptor (PRR) is
Regulated by MicroRNA-152 in Human Retinal
Endothelial Cells (hRECs). Elizabeth Hur, A.
N. Farrell, J. C. Howell, R. Haque. Department
of Ophthalmology, Emory University School of
Medicine, Atlanta, GA
3243 — A0034 Impact of Interleukin-1α on
Hyperglycemia-Induced Inflammation and
Cell Death in Müller Cells. Derrick Feenstra1, P.
Jayaguru1, C. A. Dinarello2, S. Mohr1. 1Physiology,
Michigan State University, East Lansing, MI;
2
Division of Infectious Diseases, University of
Colorado Denver, Aurora, CO
3244 — A0035 The anti-ALS drug riluzole
attenuates MCP-1 by high glucose, advanced
glycation end product (AGE) or TNF-α in
cultured human retinal pericytes. Kyung Sook
Cho3, Y. Yoon1, J. Choi3, J. Koh2. 1Ophthalmology,
College of Medicine, Asan Medical Center,
Seoul, Republic of Korea; 2Neurology, College of
Medicine, Asan Medical Center, Seoul, Republic
of Korea; 3Neural Injury Research Center, Asan
Medical Center, Seoul, Republic of Korea *CR
3245 — A0036 Ischemic conditioning protects
from axoglial alterations of the optic pathway
induced by experimental diabetes in rats. Diego
C. Fernandez, D. Dorfman, R. E. Rosenstein.
Universidad de Buenos Aires/CONICET, Buenos
Aires, Argentina
3246 — A0037 The Role of RANTES
And Chemokine Receptors in the Retinal
Degeneration in Rd Mice. Huiyang Zeng, X. Chen.
Being Tongren Eye Center, Beijing Tongren Hosp,
Capital Med Univ, Beijing, China
3247 — A0038 Effect of enriched environment
housing on glutamate-induced damage in adult
rat retina. Damian Dorfman, D. C. Fernandez,
M. S. Chianelli, M. L. Aranda, R. E. Rosenstein.
Human Biochem/Sch of Med, University of Buenos
Aires, Buenos Aires, Argentina
3248 — A0039 Neuropeptide Y protects
ganglion cells against excitotoxicity and
modulates microglia activation in the rat retina.
Antonio F. Ambrosio1, 2, F. Elvas2, 3, M. H. Madeira2,
T. Martins2, 3, J. Martins2, D. Brudzewsky2, 3, C.
Cavadas1, 4, A. Santiago2, 1. 1Centre Neurocience
Cell Biology, University of Coimbra, Coimbra,
Portugal; 2Centre of Ophthalmology and Vision
Sciences, IBILI, Faculty of Medicine, University
of Coimbra, Coimbra, Portugal; 3AIBILI, Coimbra,
Portugal; 4Faculty of Pharmacy, University of
Coimbra, Coimbra, Portugal
3249 — A0040 Neuroprotective effects of
siRna, targeted caspase 3 on rat retinal damage
induced by different time course of transient
Ischemic Injury. Shinichiro Ishikawa1, A. Hirata1,
J. Nakabayashi2, 1, R. Iwakiri1, S. Okinami1. 1Saga
Univ Faculty of Medicine, Saga, Japan; 2Saga
Memorial Hospital, Saga, Japan
3250 — A0041 Neuroprotective Effect of
DHEA-derivative BNN27 against N-MethylD-Aspartate-induced Retinal Excitotoxicity in
Mice. Pavlina A. Tsoka1, 2, I. Charalampopoulos3,
A. Gravanis3, D. Vavvas2, M. K. Tsilimbaris1, 4.
1
Neurology & Sensory Organs, Eye Research
Lab, University of Crete, School of Medicine,
Heraklion, Crete, Greece; 2Massachusetts Eye
and Ear Infirmary, Angiogenesis Lab, Harvard
Medical School, Boston, MA; 3Pharmacology,
University of Crete, School of Medicine, Heraklion,
Crete, Greece; 4Eye Clinic, University Hospital of
Heraklion, Heraklion, Crete, Greece *CR
3251 — A0042 Leukemia inhibitory factor
expression can be induced by agonist of TLR2 or gp130, and may require NF-kappa B or
STAT3 binding to promoter elements. Jiangang
Wang, J. Zhang, J. D. Ash. Ophthalmology, Florida
University, Gainesville, FL
3252 — A0043 Poly-ADP-glycohydrolase
(PARG) expression in wild-type and PARG110 knock-out retina. Ayse Sahaboglu Tekgoz1,
N. Tanimoto2, S. Bolz1, M. Garcia Garrido2, M.
W. Seeliger2, E. Zrenner1, M. Ueffing1, F. PaquetDurand1. 1Division of Experimental Ophthalmology,
Centre for Ophthalmology, Tuebingen, Germany;
2
Division of Ocular Neurodegeneration, Centre for
Ophthalmology, Tuebingen, Germany *CR
3253 — A0044 Genetic deletion of TLR4
increases retinal ganglion cell survival after optic
nerve injury. Ying Hu, M. Yuan, T. Han, J. Cao, S.
J. Wiegand, G. D. Yancopoulos. Ophthalmology,
Regeneron Inc, Tarrytown, NY *CR
3254 — A0045 Evaluation of CNTF plus
Electrical Stimulation Combined Therapies in
the RCS Rat Model of Retinitis Pigmentosa.
Tracy S. Obertone1, 2, M. H. Aung2, M. T. Pardue1, 2,
V. T. Ciavatta1, 2. 1Research, Atlanta VA Medical
Center, Decatur, GA; 2Ophthalmology, Emory
University, Decatur, GA
3255 — A0046 Receptor interacting protein
(RIP) kinases-mediated necrosis is involved
in photoreceptor degeneration in mice
lacking interphotoreceptor retinoid-binding
proteins (IRBP). Kota Sato1, 2, S. Li1, 2, M. Jin1, 2.
1
Neuroscience, LSU Health Science Center, New
Orleans, LA; 2Ophthalmology, LSU Health Science
Center, New Orleans, LA
3256 — A0047 Background Data in a Blue
Light Model of Retinal Degeneration in the
Albino Mouse. Kelly Tenneson, M. Vezina. Ocular
and Neuroscience, Charles River, Montreal, QC,
Canada *CR
3257 — A0048 Norrin mediates
neuroprotective effects on retinal ganglion cells
via the induction of leukemia inhibitory factor.
Andreas Ohlmann, S. Leopold, R. Seitz, E. R. Tamm.
University of Regensburg, Institute of Human
Anatomy and Embryology, Regensburg, Germany
3258 — A0049 Photoreceptor Protection
in P23H RHO Transgenic Mice by Systemic
Delivery of rAAV.EpoR76E. Ana M. de
Lucas-Cerrillo1, 2, L. D’Surney2, T. S. Rex1, 2.
1
Ophthalmology and Visual Sciences, Vanderbilt.
University, Nashville, TN; 2Ophthalmology,
UTHSC, Memphis, TN *CR
3259 — A0050 Remote ischemia: effects on
retinal function and neuroprotection in a light
damage model. Alice Brandli1, 2, S. Spana1, 2,
J. Stone1, 2. 1Physiology, University of Sydney,
Camperdown, NSW, Australia; 2Bosch institute,
University of Sydney, NSW, Australia
3260 — A0051 Neuroprotective Effects of
IGF-1 on Retinal Ganglion Cell Survival and
Axonal Outgrowth. Jie Ma, C. Guo, D. F. Chen, K.
Lashkari. Department of Ophthalmology, Harvard
Medical School, Schepens Eye Research Institute,
Boston, MA *CR
3261 — A0052 VEGF receptor-2 mediated
neuro-protection is required for cone
photoreceptor survival under hypoxic condition.
Yun-Zheng Le, M. Zhu. Medicine, Cell Biology, and
Harold Hamm Diabetes Center, Univ of Oklahoma
Hlth Sci Ctr, Oklahoma City, OK
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
224
Tuesday – Posters – 3262 – 3281
3262 — A0053 Lycium barbarum Extracts
Preserve Retinal Function and Reduce Neuronal
Damage in a Mouse Model of Transient Retinal
Ischemia. Di Yang1, D. Ma1, R. Chang2, 3, K.
So2, 3, S. Wong1, 3, A. C. Lo1, 3. 1Department of
Ophthalmology, Li Ka Shing Faculty of Medicine,
The University of Hong Kong, Hong Kong, Hong
Kong; 2Department of Anatomy, Li Ka Shing
Faculty of Medicine, The University of Hong Kong,
Hong Kong, Hong Kong; 3Research Center of
Heart, Brain, Hormone and Healthy Aging, Li Ka
Shing Faculty of Medicine, The University of Hong
Kong, Hong Kong, Hong Kong
3263 — A0054 The synaptic clustering protein
Vesl-1/Homer 1 mediates protection of retinal
neurons. Peter Koulen. Ophthalmology / Vision
Research Center, University of Missouri-Kansas
City, Kansas City, MO
3264 — A0055 Rewiring of photoreceptor cell
synapses following rod or cone degeneration in
zebrafish. Carole Saade, J. M. Fadool. Biological
Science, Florida State University, Tallahassee, FL
3265 — A0056 Oral Administration of
Picrorrhizae Extract Ameliorates Retina
Damage in Rat Optic Nerve Crush Model. Yang
Qu, S. Zhang, R. Li. Opthalmology, Shenyang 4th
People’s Hospital, Shenyang Eye Research Institute,
Shenyang, China
3267 — A0058 Absence of a functional P2X7
receptor slows photoreceptor degeneration in
the rd1 mouse. Kirstan A. Vessey, A. I. Jobling,
E. L. Fletcher. Anatomy and Neuroscience,
The University of Melbourne, Melbourne, VIC,
Australia *CR
3268 — A0059 Role of Adenosine Kinase in
Traumatic Optic Neuropathy. Saif Ahmad1, N.
Elsherbiny1, 2, A. Elsherbini1, S. Fulzele3, G. I.
Liou1. 1Ophthalmology, Georgia Health Sciences
University, Augusta, GA; 2Mansoura University,
Mansoura, Egypt; 3Orthopedics, Georgia Health
Sciences University, Augusta, GA
3269 — A0060 Safety and Efficacy of Retinal
Optogenetic Therapy in Canine Models.
Keirnan Willett1, 4, A. M. Maguire1, J. A. Sahel2, J.
Bennicelli1, B. Roska3, S. A. Picaud2, G. M. Acland5,
L. H. Vandenberghe6, J. Bennett1. 1F.M. Kirby
Center for Molecular Ophthalmology, University
of Pennsylvania, Philadelphia, PA; 2L’institut de la
Vision, Paris, France; 3Friedrich Miescher Institute,
Basel, Switzerland; 4Howard Hughes Medical
Institute, Chevy Chase, MD; 5Baker Institute for
Animal Health, Cornell University, Ithaca, NY;
6
Ophthalmology, Schepens Eye Research Institute,
Massachusetts Eye and Ear Infirmary, Harvard
Medical School, Boston, MA *CR
3271 — A0062 Intrauterine growth restriction
is associated with long-term retinal dysfunction
in rats. Yves Sauve1, S. L. Bourque2, S. Kuny1, S.
Davidge2. 1Dept of Ophthalmology, University of
Alberta, Edmonton, AB, Canada; 2Obstetrics and
Gynecology, University of Alberta, Edmonton, AB,
Canada
Exhibit Hall A0123-A0150
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Physiology/Pharmacology
339 AMD: New Drugs, Delivery
Systems, and Mechanisms of Action
Moderator: Maurizio G. Uva
3272 — A0123 Rationale for Treating Wet
AMD in Human Using an Oral Pill Consisting of
a VEGFR/PDGFR Inhibitor X-82. Chris Liang1,
D. M. Brown2, N. A. Chaudhry3, M. J. Elman4, J.
S. Heier5. 1Xcovery, LLC, West Palm Beach, FL;
2
Retina Consultants of Houston, Houston, TX;
3
New England Retina Associates, New London, CT;
4
Elman Retina Group, Baltimore, MD; 5Ophthalmic
Consultants of Boston, Boston, MA *CR, f
3276 — A0127 Protection of RPE cells by
sulindac against oxidative damage is through
ischemic preconditioning (IPC) and involves
activation of the peroxisome proliferator
activated receptor alpha (PPAR α). Arunodoy
Sur1, D. Baronas-Lowell2, M. R. Biswal1, H. M.
Prentice3, H. Weissbach2, J. C. Blanks1. 1Complex
Systems, Florida Atlantic University, Boca
Raton, FL; 2CMBB, Florida Atlantic University,
Jupiter, FL; 3College of Medicine, Florida Atlantic
University, Boca Raton, FL *CR
3277 — A0128 NAT2 Study: Omega-3 Levels
in Red Blood Cells Membranes Correlates the
Preventive Effect. Eric H. Souied, C. Delcourt, G.
Querques, B. Merle, T. Smith, P. Benlian. Retina
Creteil, University Paris Est Creteil, Creteil, France
*CR, f
3278 — A0129 Role of Oil Palm Phenolics in
Angiogenesis and Inflammation. Souska Zandi1, 2,
S. Nakao1, 3, D. Sun1, K. Hayes4, F. Hafezi2, A.
Hafezi-Moghadam1. 1Radiology, Brigham and
Women’s Hospital, Boston, MA; 2Ophthalmology,
Geneva University Hospitals, Geneva, Switzerland;
3
Ophthalmology, Kyushu University, Fukuoka,
Japan; 4Nutrition and Biology, Brandeis University,
Waltham, MA *CR
3279 — A0130 Bivalent ranibizumab is more
active in vitro than bevacizumab. Hanieh
Khalili1, 2, S. Brocchini1, 2, P. T. Khaw2. 1UCL
School of Pharmacy, London, United Kingdom;
2
National Institute for Health Research (NIHR)
Biomedical Research Centre at Moorfield Eye
Hospital NHS Foundation Trust and UCL Institute
of Ophthalmology, London, United Kingdom *CR
3273 — A0124 A Novel Endogenous Glycan
Therapy For Retinal Diseases: Safety, In vitro
Stability, Ocular Pharmacokinetics and Biodistribution. Shankar Swaminathan1, H. Li1, M.
Palamoor1, D. Madhura2, B. Meibohm2, M. M.
Jablonski1. 1Ophthalmology, Hamilton Eye Inst,
Univ TN HSC, Memphis, TN; 2Pharmaceutical
Sciences, The University of Tennessee Health
Science Center, Memphis, TN *CR
3280 — A0131 Omega-3 long chain
polyunsaturated fatty acids promote choroidal
neovessel regression. Ryoji Yanai1, L. Mulki1,
K. Takeuchi1, J. H. Sweigard1, J. Suzuki1, P. Y.
Gaissert1, D. Vavvas1, W. Schunck2, J. W. Miller1,
K. M. Connor1. 1Ophthalmology, Massachusetts
Eye & Ear Infirmary Harvard Medical School,
Boston, MA; 2Max Delbrück Center for Molecular
Medicine, Berlin, Germany *CR
3274 — A0125 A Single 700 μg Dexamethasone
Intravitreal Implant (Ozurdex) Effectively
Treats Complex Post-Operative Cystoid Macular
Edema. Daniel F. Kiernan1, 2, G. Stoller1, K.
B. Carnevale1, N. C. Mondoc1, E. Donnenfeld1.
1
Ophthalmic Consultants of Long Island, Rockville
Centre, NY; 2Ophthalmology, Winthrop Hospital
Medical Center, Mineola, NY *CR
3281 — A0132 Preprogrammed Hematopoietic
Stem Cells as a Systemic Therapy for Dry AMD.
Maria B. Grant1, X. Qi2, Y. Yan1, L. C. Shaw1, A.
S. Lewin3, M. E. Boulton2. 1Pharmacology and
Therapeutics, University of Florida, Gainesville,
FL; 2Anatomy and Cell Biology, University of
Florida, Gainesville, FL; 3Molecular Genetics and
Microbiology, University of Florida, Gainesville,
FL *CR
3275 — A0126 Ritonavir Inhibits HIF-1α
Mediated VEGF Expression in Retinal Pigment
Epithelial Cells. Ramya Krishna Vadlapatla,
A. Vadlapudi, D. Pal, M. Mukherji, A. K. Mitra.
Department of Pharmaceutical Sciences, University
of Missouri Kansas City, Kansas City, MO
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
225
Tuesday Posters
11:00 am – 12:45 pm
3266 — A0057 The Cannabinoid Agonist
HU210 Delays Retinal Degeneration and Vision
Loss. Pedro Lax, C. Altavilla, G. Esquiva, N.
Cuenca. Physiology, Genetics and Microbiology,
University of Alicante, Alicante, Spain *CR
3270 — A0061 Serotonin Receptor Modulation
and Neuroprotection in Models of Light
Damage and Retinal Degeneration. Keith V.
Michaels, A. Johnson, M. J. Gale, S. P. Davin,
A. K. Garg, M. D. Andrews, H. E. Titus, M. E.
Pennesi. Ophthalmology, Oregon Health & Science
University, Portland, OR *CR
3282 – 3301 – Tuesday – Posters
3282 — A0133 Structure-Activity Relationship
Studies of a Natural Product Inhibitor
of Choroidal Angiogenesis. Halesha D.
Basavarajappa1, 2, B. Lee3, X. Fei3, C. Magaña4,
C. Waller5, N. R. Crouch6, 7, D. A. Mulholland5, S.
Seo3, T. W. Corson1, 2. 1Biochemistry and Molecular
Biology, Indiana University School of Medicine,
Indianapolis, IN; 2Ophthalmology, Indiana
University school of Medicine, Indianapolis, IN;
3
Pharmacy, Gachon University, Incheon, Republic
of Korea; 4Melvin and Bren Simon Cancer
Center, Indiana University School of Medicine,
Indianapolis, IN; 5Chemistry, University of Surrey,
Guildford, United Kingdom; 6Chemistry and
Physics, University of KwaZulu-Natal, Durban,
South Africa; 7Ethnobotany, South African National
Biodiversity Institute, Durban, South Africa *CR
Tuesday Posters
11:00 am – 12:45 pm
3283 — A0134 Intravitreal Tanibirumab, a
Fully Human Monoclonal Antibody against
Vascular Endothelial Growth Factor Receptor
2, Suppresses and Regresses Laser-induced
Choroidal Neovascularization in a Rat Model.
Jaeryung Kim1, S. Shim2, S. Kim2, W. Lee2, J. Yoo2,
S. Lee2, S. Kim1. 1Ophthalmology, Samsung Medical
Center, Seoul, Republic of Korea; 2PharmAbcine,
Inc., Daejeon, Republic of Korea *CR
3284 — A0135 Functional characterization of
recombinant anti-VEGF variants in vitro. Tobias
Wimmer, B. Lorenz, K. Stieger. Department of
Ophthalmology, Justus-Liebig University Giessen,
Giessen, Germany *CR
3285 — A0136 Long-term efficacy of ciliary
muscle gene transfer of three sFlt-1 variants
in a rat model of laser-induced choroidal
neovascularization. Mohamed El Sanharawi1, 2,
E. Touchard3, R. Benard3, P. Bigey4, V. Escriou4, C.
Mehanna1, 2, M. Naud1, J. P. Jeanny1, M. Berdugo
Polak1, F. F. Behar-Cohen1, 2. 1INSERM UMRS 872,
Paris, France; 2Université Pierre et Marie-Curie,
Paris, France; 3Eyevensys, Paris, France; 4INSERM
U640, Paris, France *CR
3286 — A0137 Immune-Like Complexes of
Bevacizumab Bind to Retinal Pigment Epithelial
Cells and Endothelial Cells in vitro. Yang Liu1, T.
B. Potocky2, J. Cao1, J. Martin2, N. Papadopoulos2,
S. J. Wiegand1. 1Ophthalmology, Regeneron
Pharmaceuticals Inc, Tarrytown, NY; 2Molecular
Biology, Bioassay, & Protein Development,
Regeneron Pharmaceuticals Inc, Tarrytown, NY
*CR
3287 — A0138 A Mechanism-Based
Binding Model for the Pharmacokinetics and
Pharmacodynamics (PK-PD) of RN6G (PF04382923), a Humanized Monoclonal Antibody
against Amyloid β Peptides, in Subjects with Dry,
Age-Related Macular Degeneration Including
Geographic Atrophy. Kai H. Liao1, P. D. Garzone2,
S. S. Bollini2, P. M. Fanning2, G. Wong2, X. Meng1.
1
Pfizer Inc, San Diego, CA; 2Pfizer Inc, South San
Francisco, CA *CR, f
3288 — A0139 Short Term Effect of
Intravitreal Aflibercept Injection In IntraOuclar
Pressure. Kasra Attaran-Rezaei, C. Moazez, C.
H. Sell, A. J. Gordon, R. Reddy, H. M. Kwong, S.
De Souza, M. C. Ziemianski, B. Shirkey, S. Bryan.
Ophthalmology & Visual Science, Associated
Retina Consultants, Phoenix, AZ
3296 — A0147 Effect of Apolipoprotein A1mimetic peptides on cell viability of cultured
retinal pigment epithelial cells. Yoko Miura1, 2,
I. Fritz1, S. Grisanti1, M. Rudolf1. 1Department of
Ophthalmology, University of Luebeck, Luebeck,
Germany; 2Institute of Biomedical Optics,
University of Luebeck, Luebeck, Germany *CR
3289 — A0140 In vivo imaging of fluorescent
probes linked to antibodies against human and
rat vascular endothelial growth factor (VEGF).
Johanna Meyer1, A. Cunea1, P. Welker2, K. Licha2,
D. Sonntag-Bensch1, S. Schmitz-Valckenberg1, F. G.
Holz1. 1Department of Ophthalmology, University
of Bonn, Bonn, Germany; 2Mivenion GmbH,
Berlin, Germany *CR
3297 — A0148 Beta cyclodextrins bind and
remove Lipofuscin Bisretinoids from RPE.
Marcelo M. Nociari. Ophthalmology, Weill Cornell
Medical College, New York, NY
3290 — A0141 Generation of Combination
PDGF / VEGF-antagonist ECT devices. Vincent
Ling, A. Nystuen, S. A. Elliott, L. Orecchio, B. Dean,
K. Kauper, W. Tao. Biological Sciences, Neurotech
USA, Cumberland, RI *CR
3291 — A0142 Morphological Study of
the Ganglion Cell Layer of Rabbits After
Intravitreal Injection of Mycophenolic Acid.
Andre M. Liber1, R. M. Ferraro1, D. F. Ventura1,
F. Damico2, 1, C. Joselevitch1. 1Psychology
Experimental, Universidade de Sao Paulo, Sao
Paulo, Brazil; 2medical school, universidade de são
Paulo, São Paulo, Brazil
3292 — A0143 Development and
Characterization of a 3-Dimensional Human
Corneal Full Thickness Tissue Model. Yulia
Kaluzhny, L. d’Argembeau-Thornton, H.
Kandarova, P. Hayden, M. Klausner. MatTek
Corporation, Ashland, MA *CR
3293 — A0144 Nutritional supplementation
for age related macular degeneration in Italy.
Ilaria Zucchiatti1, M. B. Parodi1, M. cicinelli2, M.
Cascavilla1, F. Fasce1, M. Prati1, F. Bandello1.
1
Department of Ophthalmology, University VitaSalute, Scientific Institute San Raffaele, Milan,
Milano, Italy; 2University Vita Salute San Raffaele,
Milan, Italy *CR
3294 — A0145 Feasibility of Cryopreservation
of the Encapsulated Cell Technology Devices.
Cahil McGovern1, J. D. Duggan3, C. Cortellessa1,
S. Sherman1, M. Stiles2, K. Kauper4, A. Mazzarelli6,
W. Tao5. 1Manufacturing, Neurotech, Cumberland,
RI; 2Quality Control, Neurotech, Cumberland,
RI; 3Quality Assurance, Neurotech, Cumberland,
RI; 4Engineering, Neurotech, Cumberland,
RI; 5Research and Development, Neurotech,
Cumberland, RI; 6Histology, Neurotech,
Cumberland, RI *CR
3295 — A0146 Continuous Intraocular Drug
Delivery over 5 ½ Years: Ciliary Neurotrophic
Factor (CNTF)Production by Encapsulated Cell
Technology Implants Treating Patients with
Retinitis Pigmentosa and Geographic Atrophy.
Konrad Kauper, C. McGovern, P. Stabila, S.
Sherman, P. Heatherton, B. Dean, C. Cortellessa,
A. Lee, W. Tao. Core Technology Development,
Neurotech USA, Cumberland, RI *CR
3298 — A0149 Safety of implantation of
the NT-503 device in patients with Choroidal
Neovascularization secondary to Age-related
Macular Degeneration. Jose Luis GuerreroNaranjo1, H. Quiroz-Mercado3, G. SanchezBermudez1, F. Schoonewolff1, S. Salinas Longoria1,
R. Romero Vera1, W. Tao2, R. L. Beckman2, V.
Morales-Canton1. 1Retina, Asoc Para Evitar
la Ceguera en Mexico, Mexico City, Mexico;
2
Neurotech, Inc., Cumberland, RI; 3Denver Health
Medical Center, Denver, CO *CR
3299 — A0150 Suprachoroidal Microinjection
of Bevacizumab is Well Tolerated in Human
Patients. Virgilio Morales-Canton1, J. J. FromowGuerra1, S. Salinas Longoria1, R. Romero Vera1, M.
Widmann2, S. R. Patel2, B. Yerxa1. 1The Asociación
Para Evitar La Ceguera (APEC), Mexico City,
Mexico; 2Clearside Biomedical, Alpharetta, GA
*CR
Exhibit Hall B0188-B0232
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Retina
340 Vitreoretinal Surgery II
Moderators: Baruch D. Kuppermann and Vinit B.
Mahajan
3300 — B0188 Amber Filter vs Conventional
Xenon Light source for 23 Gauge pars plana
vitrectomy in epiretinal membrane: OCT and
Autofluorescence findings. Michele Coppola1, M.
Lizzano2, 1, S. Marchi3, 1. 1Ophthalmology, Azienda
Ospedaliera di Desio e Vimercate (MB), Milano,
Italy; 2Ophthalmology, Clinica San Carlo, Paderno
Dugnano, Italy; 3Ophthalmology, Arcispedale Santa
Maria Nuova, Reggio Emilia, Italy
3301 — B0189 Pars plana vitrectomy with
medium-term perfluoro-n-octane (PFO) for
severe proliferative diabetic retinopathy (PDR)
with traction retinal detachment (TRD). Carmen
L. Gonzalez1, 2, R. Bhandari1, 2, S. Schwartz1, 2,
N. Mandava1, J. Olson1, S. Oliver1, V. MoralesCanton3, M. Mathias1, 2, H. Quiroz-Mercado1, 2.
1
Colorado University, Denver, CO; 2Denver Health
Hospital, Denver, CO; 3Asociacion para evitar la
ceguera APEC, Mexico City, Mexico *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
226
Tuesday – Posters – 3302 – 3327
3302 — B0190 Anatomical and functional
outcomes of macular hole surgery in a single VR
unit (2005-2012). Robert Johnston1, J. ZarranzVentura1, 2, A. Sallam1, D. A. Sim2, P. A. Keane2, N.
Kirkpatrick1. 1Vitreo-Retinal Service, Cheltenham
General Hospital, Cheltenham, United Kingdom;
2
Medical Retina Service, National Insitute for
Health Research (NIHR) Biomedical Research
Centre at Moorfields Eye Hospital NHS Foundation
Trust and UCL Institute of Ophthalmology, London,
United Kingdom *CR
3309 — B0197 Analysis of a Blend of
Poly(acryamide) Gels with Varying Sodium
Acrylate Formulations for Use in Vitreous
Hydrogel Substitutes. Paul D. Hamilton1, 2, N.
Iyer4, 2, N. Ravi1, 3. 1Ophthalmology Research,
VA Health Care System, St Louis, MO;
2
Ophthalmology, Washington University, St.
Louis, MO; 3Energy, Environmental and Chemical
Engineering, Washington University, St. Louis, MO;
4
Biomedical Engineering, Washington University,
St. Louis, MO
3303 — B0191 Vitreoretinal Surgical Outcomes
Performed by Supervised Retinal Fellows
Versus Attending Faculty Surgeons. John O.
Mason1, 2, J. O. Mason1, G. McGwin2, L. B. Mason1,
T. A. Finley1, D. A. Friedman1, 2, D. Pomerleau1,
M. A. Albert1, 2, R. M. Feist1, 2, M. L. Thomley1, 2.
1
Retina Consultants of Alabama, Birmingham,
AL; 2University of Alabama Department of
Ophthalmology, Birmingham, AL
3310 — B0198 Correlation of anesthetic
medications with required airway interventions
during retrobulbar anesthesia. Lingmin He1, J. C.
Leng2, R. A. Silva1, T. Leng1. 1Byers Eye Institute at
Stanford, Stanford University School of Medicine,
Palo Alto, CA; 2Anesthesia, Stanford University
School of Medicine, Stanford, CA f
3304 — B0192 Functional and Anatomical
Outcomes of Tissue Plasminogen Activator
(tPA) Treatment for Submacular Hemorrhage
Associated with Exudative Macular
Degeneration (ExAMD): A Comparative
Analysis Between Intra-vitreal and Sub-retinal
tPA injected Patients. Mark Sherman, S. Schaal, C.
C. Barr. Ophthamology, University of Louisville,
Louisville, KY
3306 — B0194 Quantitative proteomics of
vitreous humor to identify potential markers
involved in the induction of posterior vitreous
detachment. Ravi Keshavamurthy1, J. Koh2, S.
Chen2, K. Chalam1. 1Ophthalmology, University
of Florida Eye Institute, Jacksonville, FL;
2
Interdisciplinary Center for Biotechnology
Research, University of Florida, Gainesville, FL
3307 — B0195 Fog formation on intraocular
lenses during vitrectomy: Effect of
Perfluorocarbon Liquids. Joshua D. Udoetuk1, F.
Tavakoli2, J. Verret2, A. Keshavan2, P. Kavehpour2,
J. Hubschman1. 1Ophthalmology, Jules Stein Eye
Institute at UCLA, Los Angeles, CA; 2Mechanical
and Aerospace Engineering, UCLA, Los Angeles,
CA
3308 — B0196 Impact of Surgical Peeling
on Retinal Microarchitecture in Epiretinal
Membrane Surgery Visualized with
Intraoperative Optical Coherence Tomography.
Justis P. Ehlers, B. Roth, P. K. Kaiser, R. Singh, S.
K. Srivastava. Cole Eye Institute-Retina Service,
Cleveland Clinic, Cleveland, OH *CR
3312 — B0200 Blue Perfluoro-n-Octane and
Blue Perfluorodecaline Stability and Residue
Testing. Fabio M. Trindade1, 3, J. Garcia-Arumi1, 2.
1
Universitat Autonoma de Barcelona, Barcelona,
Spain; 2Hospital Vall D’Hebron, Barcelona, Spain;
3
Hospital Dr. Nélio Mendonça, Funchal, Portugal
3313 — B0201 Relation between retinal
vessel printings and visual acuity in patients
with macular epiretinal membranes. Roberto
dell’Omo, F. Cifariello, M. Cassetta, D. Angela, A.
De Lena, M. Filippelli, E. dell’Omo, C. Costagliola.
Medicine and Health Sciences, University of
Molise, Campobasso, Italy
3314 — B0202 Two-year Results of AcrySof
Toric Intraocular Lens Implantation in Patients
with Combined Microincision Vitrectomy
Surgery and Phacoemulsification. Dong Ho Park,
J. Lee, J. Shin, I. Kim. Ophthalmology, Kyungpook
National Univ Hospital, Daegu, Republic of Korea
3315 — B0203 Retinal Unfolding after
Vitrectomi for Idiopathic Macular Pucker.
Mads Kofod, M. D. de La Cour. University of
Copenhagen, Glostrup, Denmark *CR, f
3316 — B0204 Clouding of intraocular
silicone oil in the absence of emulsification.
Martin S. Spitzer1, J. de Vries2, A. Herrmann2, K.
Bartz-Schmidt1, S. Dammeier1. 1Ophthalmology,
Tuebingen University Eye Center, Tuebingen,
Germany; 2University of Groningen, Zernike
Institute for Advanced Materials Department of
Polymer Chemistry, Groningen, Netherlands *CR
3317 — B0205 25-gauge Vitrectomy For
Macular Holes With And Without Retinal
Detachment In Highly Myopic Eyes. Francesco
Boscia, N. Recchimurzo, L. Sborgia, E. Giancipoli,
C. Furino. Ophthalmology, University of Bari, Bari,
Italy
3319 — B0207 Macular hole formation after
vitrectomy ; Preventable? Rebecca Kim, Y. Kim,
K. Kim. Department of Ophthalmology, Dongsan
Medical Center, Keimyung University, Daegu,
Republic of Korea
3320 — B0208 Surgical outcomes of idiopathic
epiretinal membrane with good visual acuity.
Sung Il Kim1, S. Cho2, S. Park1, I. Byon1, J.
Jung2, J. Lee2, J. E. Lee1. 1Ophthalmology, Pusan
National University Hospital, Busan, Republic of
Korea; 2Ophthalmology, Yangsan Pusan National
University Hospital, Yangsan, Republic of Korea
3321 — B0209 Mechanical Properties of
Vitreous Humor in Eye Pairs. Pirouz Kavehpour,
R. Freeman, R. Vedadghavami, S. U. Shah, R.
Amini, J. Hubschman. Mechanical & Aerospace
Engineering, University of California, LA, Los
Angeles, CA
3322 — B0210 The impact of hospital
admission on systemic adverse outcomes
after pediatric vitreoretinal surgery. Richard
Y. Hwang, A. Shalwala, A. K. Tabing, S. J. Kim.
Ophthalmology, Vanderbilt University, Nashville,
TN
3323 — B0211 Surgical Outcomes of 25-Gauge
Vitrectomy for Diabetic Tractional Retinal
Detachment. Kevin Patel, M. S. Dikopf, V. Setlur,
J. I. Lim. Ophthalmology and Visual Sciences,
University of Illinois Eye and Ear Infirmary,
Chicago, IL *CR
3324 — B0212 Visual Acuity Outcomes in
Patients Undergoing Epiretinal Membrane
(ERM) and Internal Limiting Membrane
(ILM) Peel With and Without Intraoperative
Intraocular Triamcinolone. Shawn Agee, R. Wang,
R. Winslow. Ophthalmology, University of Texas
Southwestern Medical Center, Dallas, TX
3325 — B0213 Complications in Heavy Silicone
Oil Surgery. Hendrik Schwarzer, B. A. Mazinani,
N. Plange, P. Walter, G. Roessler. Ophthalmology,
RWTH Aachen University, Aachen, Germany *CR
3326 — B0214 Speed of silicone oil removal
through common cannulas. David Cupp, C. A.
McCannel. UCLA, Los Angeles, CA *CR
3327 — B0215 The influence of vitrectomy
machine fluidics on the rate of iatrogenic retinal
breaks in primary small-gauge vitrectomies.
Renaud Duval1, 2, J. S. Pollack1, 2, J. M. Civantos1, 2,
K. H. Packo1, 2. 1Ophthalmology, Illinois Retina
Associates, Chicago, IL; 2Ophthalmology, Rush
University Medical Center, Chicago, IL *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
227
Tuesday Posters
11:00 am – 12:45 pm
3305 — B0193 Erbium:YAG Laser Scalpel
with Novel Microsphere Chain Fiber Optic
Tip for More Precise Vitreoretinal Surgery.
Howard S. Ying1, A. N. Antoszyk4, T. Hutchens2,
A. Darafsheh2, A. Fardad3, N. M. Fried2, V. N.
Astratov2. 1Retina Division, Johns Hopkins Wilmer
Eye Inst, Baltimore, MD; 2Physics and Optical
Science, University of North Carolina at Charlotte,
Charlotte, NC; 3PhotonTech LLC, Durham, NC;
4
Retina Service, Charlotte Eye Ear Nose & Throat
Associates, Charlotte, NC *CR
3311 — B0199 Characteristics of epiretinal
membranes which influence post-surgical visual
outcomes. Sahar Bedrood, L. A. Lam, S. Sadda.
Ophthalmology, Doheny Eye Institute/USC, Los
Angeles, CA *CR
3318 — B0206 Robot-assisted vitreoretinal
surgery. Mathias M. Maier1, M. Nasseri2, D. M.
Zapp1, M. Eder2, K. Kobuch1, C. P. Lohmann1,
A. Knoll2. 1Ophthalmology, Klinikum rechts der
Isar, Technische Universität München, Munich,
Germany; 2Robotics and Embeded Systems,
Technische Universität München, Munich,
Germany *CR
Tuesday Posters
11:00 am – 12:45 pm
3328 – 3348 – Tuesday – Posters
3328 — B0216 Visual Acuity and Anatomic
Outcomes Following Surgery for Myopic Macular
Retinoschisis. Jonathan S. Chang1, A. R. Shane1, M.
Engelbert3, W. E. Smiddy1, S. Chang2, H. W. Flynn1.
1
Ophthalmology, Bascom Palmer Eye Institute,
Miami, FL; 2Ophthalmology, Columbia University,
New York, NY; 3Vitreous-Retina-Macula Consultants
of New York, New York, NY *CR
3336 — B0224 Effects of Ozurdex on
Persistent Macular Edema After Vitrectomy
with Membrane Peeling. John Khadem1, 2,
S. Khorsandzadeh3, J. Pan2, C. Pieroni1, 2.
1
Ophthalmology, New York University, New
York, NY; 2Ophthalmology, New York Eye and
Ear infirmary, New York, NY; 3Metropolitan State
University of Denver, Denver, CO *CR, f
3329 — B0217 Comparison of fundus-viewing
quality using wide-field observation system
through various intraocular lenses. Haruhiko
Yamada. 1Ophthalmology, Kansai Medical
University, Hirakata, Japan; 2Yamada Eye Clinic,
Sakai, Japan
3337 — B0225 Macular function in patients
with macular pucker treated with 23 gauge
vitrectomy. Giancarlo Dell’Aversana Orabona, A.
Rampone, L. Di Perna, F. Testa, S. Rossi, M. Della
Corte, F. Simonelli. Second University of Naples,
Napoli, Italy
3330 — B0218 A new 25G back flush needle.
Shumpei Obata1, K. Someya2, M. Kakinoki1, M.
Ohji1. 1Ophthalmology, Shiga University of Medical
Science, Otsu, Japan; 2Hoya Corporation, Tokyo,
Japan *CR
3338 — B0226 Association of Retinal
Sensitivity and Morphology in epiretinal
membranes before and after vitrectomy. Patricia
Udaondo, A. Hervás Ontiveros, S. Garcia-Delpech,
D. Salom, S. Martinez-Castillo, M. Díaz-Llopis.
Ophthalmology, La Fe University Hospital,
Valencia, Spain
3331 — B0219 Ex-vivo evaluation of
thermosensitive hydrogels as vitreous substitutes.
Sabrina M. Bohnacker1, N. Hagedorn2, S. Kamlage3,
W. Kugler2, A. Lendlein3, M. M. Maier1, A. T. Neffe3,
A. Messner4, C. Lohmann1, K. Kobuch1. 1Klinik
und Polyklinik für Augenheilkunde, Klinikum
rechts der Isar, Technische Universität München,
Munich, Germany; 2Fluoron GmbH Ulm, Ulm,
Germany; 3Center for Biomaterial Development,
Institute of Polymer Research, Helmholtz-Zentrum
Geesthacht, Teltow, Teltow, Germany; 4Dr. Schmidt
Intraocularlinsen GmbH, St. Augustin, St. Augustin,
Germany *CR
3332 — B0220 Serum protein analysis of
patients with different vitreoretinal diseases
by means of antibody microarrays. Christina
A. Korb1, S. Beck1, K. Lorenz2, A. Mirshahi2, B.
Stoffelns2, N. Pfeiffer2, F. H. Grus1. 1Experimental
Ophthalmology, University Medical Center,
Mainz, Germany; 2Department of Ophthalmology,
University Medical Center, Mainz, Germany *CR
3333 — B0221 Outcomes of Idiopathic Macular
Hole Surgery. Janet Manalac, J. Frisbee, D.
Mazzulla. Ochsner Clinic Foundation, New Orleans,
LA
3334 — B0222 Inner Retinal Dimples Occur
Following Inner Limiting Membrane Peeling
Without Staining. Franck Amouyal, C. K. Pan,
S. D. Schwartz, J. Hubschman. Jules Stein Eye
Institute, Los Angeles, CA
3335 — B0223 23-Gauge Transconjunctival
Sutureless Pars Plana Vitrectomy In Different
Posterior Segment Diseases. Complications,
Visual Outcomes And Results: An Update.
Marcelo Zas1, C. P. Rinaudo1, L. Adamo1, G. Gomez
Caride2, P. Chiaradia1. 1Ophthalmology, Hosp de
Clinicas, Univ of Buenos Aires, Ciudad Autonoma
de Buenos Aires, Argentina; 2Centro de Ojos
Quilmes, Buenos Aires, Argentina
3339 — B0227 Vitrectomy with Intentional
Bullous Retinal Detachment to Mobilize
and Move Recent Subfoveal Hemorrhage in
Age-related Macular Degeneration. Deepthi
Reddy1, M. H. Oltmanns2, 1, M. R. Sapp2, 1, R. E.
Morris2, 1. 1Ophthalmology, University of AlabamaBirmingham, Birmingham, AL; 2Retina Specialists
of Alabama, Birmingham, AL
3340 — B0228 Morphological Change of Inner
Retinal Layer on Spectral Domain Optical
Coherence Tomography following Macular Hole
Surgery. Hyung-Woo Kwak, K. Kim, T. Kim, K.
Seo, S. Yu. Ophthalmology, Kyung Hee University
Hospital, Seoul, Republic of Korea
3341 — B0229 Triamcinolone Acetonide
(TA) Assisted Removal of Internal Limiting
Membrane (ILM). Homayoun Tabandeh, D. S.
Boyer, D. Liao. Retina Vitreous Assoc Med Group,
Los Angeles, CA *CR
3342 — B0230 vitrectomy outcomes for
diabetic vitreous hemorrhage. Gaston Gomez
Caride1, L. Ferlini1, L. Perrone1, G. valvecchia1, M.
Zas2. 1Retina, Centro De Ojos Quilmes, Quilmes,
Argentina; 2Retina, Hospital De Clinicas, Buenos
Aires, Argentina
3343 — B0231 Perioperative Intravitreal
Bevacizumab: When to Inject It to Be Friend
not Foe? Narcisa Ianopol. Ophthalmology, Ochiul
Diabetic, Iasi, Romania
Exhibit Hall C0001-C0039
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Genetics
341 Exome Sequencing: New Genes,
Methods and Databases
Moderator: Terry A. Braun
3345 — C0001 Exome sequencing identifies
RDH12 gene compound heterozygous mutations
in a Mexican inbred family with severe
autosomal recessive retinitis pigmentosa. Juan
C. Zenteno, O. F. Chacon-Camacho, B. Buentello,
S. Jitskii. Genetics, Institute of Ophthalmology,
Mexico City, Mexico
3346 — C0002 Exome sequencing identifies
mutations of both MYO7A and PDE6B in three
siblings with retinitis pigmentosa. Tamar BenYosef1, N. Goldenberg-Cohen2, 3, E. Banin4, B.
Cohen1, Y. Zalzstein5, L. Rizel1, L. Basel-Vanagaite5.
1
Genetics Dept - Faculty of Med, Technion, Haifa,
Israel; 2Eye Research Laboratory, FMRC, Tel-Aviv
University, Petah Tikva, Israel; 3Ophthalmology,
Rabin Medical Center, Petah Tikva, Israel;
4
Ophthalmology, Hadassah- Hebrew University
Medical Center, Jerusalem, Israel; 5Raphael
Recanati Genetic Institute, Rabin Medical Center,
Petah Tikva, Israel
3347 — C0003 Exome analysis identified novel
mutations in the FAM161A gene in a family with
recessive retinal degeneration. Jacque L. Duncan1,
P. Biswas2, I. Kozak2, M. Navani2, R. C. Caruso3,
J. R. Heckenlively4, A. Roorda5, R. Ayyagari2.
1
Ophthalmology, Univ of California - SF, San
Francisco, CA; 2Shiley Eye Center, University of
California, San Diego, La Jolla, CA; 3National Eye
Institute, National Institutes of Health, Bethesda,
MD; 4Ophthalmology, University of Michigan, Ann
Arbor, MI; 5School of Optometry, University of
California, Berkeley, Berkeley, CA *CR
3348 — C0004 Whole Exome Sequencing
as a Tool for Identification of Genes Causing
Autosomal Recessive Retinitis Pigmentosa. Dror
Sharon1, L. Zelinger1, S. Khateb1, A. Beryozkin1, L.
Mizrahi-Meissonnier1, S. G. Jacobson2, E. Banin1.
1
Department of Ophthalmology, Hadassah-Hebrew
Univ Medical Ctr, Jerusalem, Israel; 2Department of
Ophthalmology, Scheie Eye Institute, Philadelphia,
PA
3344 — B0232 12 Month Follow-up of
Epiretinal Membranectomy. David S. Dyer,
W. Anderson, M. P. Ellis. Retina Associates, PA,
Shawnee Mission, KS
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
228
Tuesday – Posters – 3349 – 3363
3349 — C0005 Identification of causative
mutations in consanguineous pedigrees from
Pakistan with recessive retinal degeneration
by whole exome analysis. Pooja Biswas1, B.
Maranhao1, 2, P. Lee1, J. Suk1, M. Navani1, S. Y.
Khan3, N. H. Butt4, S. Riazuddin4, 5, S. Riazuddin3,
R. Ayyagari1. 1Shiley Eye Center, University
of California, San Diego, San Diego, CA;
2
Bioengineering, University of California, San
Diego, San Diego, CA; 3The Wilmer Eye Institute,
Johns Hopkins University School of Medicine,
Baltimore, MD; 4Allama Iqbal Medical College,
University of Health Sciences, Lahore, Pakistan;
5
National Centre of Excellence in Molecular
Biology, University of the Punjab Lahore, Lahore,
Pakistan
3351 — C0007 A Missesne Mutation in the
Acetyl-CoA Carboxylase β Gene Involved in
Lipid Metabolism is Associated with Autosomal
Recessive Retinitis Pigmentosa. Lina Zelinger1,
C. Ayuso2, E. Banin1, D. Sharon1. 1Ophthalmology,
Hadassah Hebrew University Medical Center,
Jerusalem, Israel; 2Departamento de Genética,
Instituto de Investigación Sanitaria-Fundación
Jiménez Díaz (IIS-FJD), Madrid, Spain
3352 — C0008 RP1L1 variants are associated
with retinitis pigmentosa and occult macular
dystrophy. Panagiotis I. Sergouniotis1, 2, A. E.
Davidson1, D. S. Mackay1, G. A. Wright2, M.
Michaelides1, 2, G. E. Holder1, 2, A. G. Robson1, 2,
A. T. Moore1, 2, V. Plagnol3, A. R. Webster1, 2. 1UCL
Institute of Ophthalmology, London, United
Kingdom; 2Moorfields Eye Hospital, London,
United Kingdom; 3UCL Genetics Institute, London,
United Kingdom *CR
3354 — C0010 Exome sequencing in dogs
with progressive retinal atrophy to facilitate
the development of therapeutic intervention
studies. Rob W. Collin1, A. Henkes1, G. D. Astuti1,
C. Gilissen1, B. Lorenz2, A. Hoischen1, F. P.
Cremers1, K. Stieger2. 1Human Genetics, Radboud
University Medical Ctr, Nijmegen, Netherlands;
2
Ophthalmology, Justus-Liebig-University Giessen,
Giessen, Germany *CR
3355 — C0011 Exome Sequencing Identifies a
Novel RP1 Mutation in a Belgian Family with
Autosomal Dominant Retinitis Pigmentosa.
Caroline Van Cauwenbergh1, F. Coppieters1, S.
De Jaegere1, J. De Zaeytijd2, B. P. Leroy1, 2, E.
De Baere1. 1Centre for Medical Genetics Ghent,
Ghent University, Ghent, Belgium; 2Department of
Ophthalmology, Ghent University Hospital, Ghent,
Belgium
3356 — C0012 The familial dementia gene
revisited: ITM2B missense mutation causes
a new dominant retinal dystrophy. Isabelle
S. Audo1, 2, K. M. Bujakowska5, E. Orhan5, F.
Sennlaub5, X. P. Guillonneau5, T. D. Leveillard5,
S. Mohand-Said1, S. S. Bhattacharya2, 3, J. A.
Sahel4, C. Zeitz5. 1Univ Pierre et Marie Curie Paris
6, INSERM, UMR_S968; CNRS, UMR_7210;
CHNO, INSERM-DHOS CIC 503, Paris,
F-75012, France., Paris, France; 2UCL-Institute of
Ophthalmology, 11-43 Bath Street, London EC1V
9EL, United Kingdom., London, United Kingdom;
3
Department of Cellular Therapy and Regenerative
Medicine, Andalusian Molecular Biology and
Regenerative Medicine Centre (CABIMER), Isla
Cartuja, Seville 41902, Spain., Seville, Spain; 4Univ
Pierre et Marie Curie Paris 6, INSERM, UMR_
S968; CNRS, UMR_7210; CHNO, INSERMDHOS CIC 503; Fondation Ophtalmologique
Adolphe de Rothschild, Paris; Académie des
Sciences-Institut de France, Paris, Paris, France;
5
Univ Pierre et Marie Curie Paris 6, INSERM,
UMR_S968; CNRS, UMR_7210; CHNO, Paris,
F-75012, France., Paris, France *CR
3357 — C0013 Variant prioritization and
linkage mapping using whole-exome sequencing
data for families with autosomal dominant
retinitis pigmentosa (adRP). Daniel C. Koboldt1,
D. E. Larson1, L. S. Sullivan2, S. J. Bowne2, R. S.
Fulton1, E. Sodergren1, S. H. Blanton3, S. P. Daiger2,
R. K. Wilson1, G. M. Weinstock1. 1The Genome
Institute, Washington University, St. Louis, MO;
2
Human Genetics Center, Univ. of Texas Health
Science Ctr, Houston, TX; 3Hussman Institute of
Human Genomics, Univ. of Miami, Miami, FL *CR
3358 — C0014 Whole-exome sequencing in
age-related macular degeneration. Margaret
A. Pericak-Vance1, G. Wang1, W. Cade1, M. D.
Courtenay1, P. Gay1, S. G. Schwartz3, J. L. Kovach3,
A. Agarwal4, J. L. Haines2, W. K. Scott1. 1Human
Genomics, Univ of Miami Miller Sch of Med,
Miami, FL; 2Center for Human Genetics Research,
Vanderbilt University School of Medicine,
Nashville, TN; 3Bascom Palmer Eye Institute,
University of Miami, Miami, FL; 4Ophthalmology,
Vanderbilt University School of Medicine,
Nashville, TN *CR
3359 — C0015 Mutation analysis of
B3GALTL in Peters Plus Syndrome and alike
phenotypes. Eric Weh1, 2, L. M. Reis2, R. C. Tyler2,
E. V. Semina1, 2. 1Cell Biology, Neurobiology
and Anatomy, Medical College of Wisconsin,
Wauwatosa, WI; 2Pediatrics and Children’s
Research Institute, Medical College of Wisconsin,
Wauwatosa, WI
3360 — C0016 Next Generation Sequencing
Reveals A Novel Gene Mutation in Primary
Congenital Glaucoma Patients. Terri L. Young1, 2,
S. H. Lim2, 3, T. Yanovitch1, 3, T. P. Klemm2, E.
St.Germain3, S. Maurer-Stroh5, V. Limviphuvadh5, N.
Katsanis4, S. Rozen2, K. Tran-Viet3. 1Ophthalmology,
Duke University Eye Center, Durham, NC;
2
Computational Biology, Duke-National University
of Singapore, Singapore, Singapore; 3Medicine,
Duke Center for Human Genetics, Durham, NC;
4
Medicine, Duke Center for Human Disease
Modeling, Durham, NC; 5Bio-informatics Institute,
Agency for Science, Technology and Research,
Singapore, Singapore *CR
3361 — C0017 CCDC111 mutation was
identified in high myopia through exome
sequencing. Fuxin Zhao, X. Zhou, A. Xue, Y. Su,
J. Qu. School of Ophthal & Optometry, Wenzhou
Medical College, Wenzhou, China
3362 — C0018 The superior ocular fissure:
a novel finding in early eye development. Tara
Stach1, 2, J. Famulski2, A. Waskiewicz2, O. J.
Lehmann1, 3. 1Medical Genetics, University of
Alberta, Edmonton, AB, Canada; 2Biological
Sciences, University of Alberta, Edmonton, AB,
Canada; 3Ophthalmology, University of Alberta,
Edmonton, AB, Canada
3363 — C0019 ALDH1A3 mutations cause
recessive anophthalmia and microphthalmia.
Lucas Fares Taie1, S. Gerber1, N. Chassaing2,
J. Clayton-Smith3, E. D. Silva4, A. Munnich1, P.
Calvas2, J. Kaplan1, N. Ragge5, J. Rozet1. 1Genetics,
Inserm U781, Paris, France; 2Genetics, Chu
Toulouse, Toulouse, France; 3Genetic Medicine,
St Mary’s Hospital, Manchester, United Kingdom;
4
Ophthalmology, Coimbra University Hospital,
Coimbra, Portugal; 5Clinical Genetics, University
Hospital Southampton, Southampton, United
Kingdom
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
229
Tuesday Posters
11:00 am – 12:45 pm
3350 — C0006 Whole exome sequencing
identifies mutations in LRIT3 as a cause for
autosomal recessive complete congenital
stationary night blindness. Christina Zeitz1, S. G.
Jacobson2, C. P. Hamel3, K. M. Bujakowska1, M.
Neuillé1, E. Orhan1, X. Zanlonghi4, J. A. Sahel6, S. S.
Bhattacharya5, 7, I. S. Audo8, 5. 1Institut de la Vision,
Univ Pierre et Marie Curie Paris 6, INSERM,
UMR_S968; CNRS, UMR_7210, Paris, F-75012,
France; 2University of Pennsylvania, Scheie Eye
Institute, Philadelphia 19104, PA; 3Inserm U.
583, Physiopathologie et thérapie des déficits
sensoriels et moteurs, Institut des Neurosciences
de Montpellier, Hôpital Saint-Eloi, Montpellier,
34295 Cedex 05, France; 4Service Exploration
Fonctionnelle de la Vision et Centre basse vision de
la Clinique Sourdille, Nantes 44000, France; 5UCLInstitute of Ophthalmology, 11-43 Bath Street,
London EC1V 9EL, United Kingdom; 6Univ Pierre
et Marie Curie Paris 6, INSERM, UMR_S968;
CNRS, UMR_7210; CHNO, INSERM-DHOS
CIC 503; Fondation Ophtalmologique Adolphe de
Rothschild, Paris; Académie des Sciences-Institut
de France, Paris, F-75012, France; 7Department
of Cellular Therapy and Regenerative Medicine,
Andalusian Molecular Biology and Regenerative
Medicine Centre (CABIMER), Isla Cartuja, Seville
41902, Spain; 8Univ Pierre et Marie Curie Paris
6, INSERM, UMR_S968; CNRS, UMR_7210;
CHNO, INSERM-DHOS CIC 503, Paris, F-75012,
France *CR
3353 — C0009 RNA-Seq Approach for the
Refinement of a Modifier Locus in a Canine
Model of Cone-Rod Dystrophy. Keiko Miyadera1,
M. Brooks2, G. Das1, A. Swaroop2, G. D. Aguirre1.
1
School of Vet Medicine, Univ of Pennsylvania,
Philadelphia, PA; 2National Eye Institute, NIH,
Bethesda, MD
3364 – 3379 – Tuesday – Posters
3364 — C0020 Whole exome sequencing
identifies novel mutations in OTX2, CRYBA4,
and PAX6 in microphthalmia patients. Brett
Deml1, 2, L. M. Reis1, E. V. Semina1, 2. 1Pediatrics,
Medical College of Wisconsin, Milwaukee, WI;
2
Cell Biology, Neurobiology & Anatomy, Medical
College of Wisconsin, Milwaukee, WI
Tuesday Posters
11:00 am – 12:45 pm
3365 — C0021 Exome Sequencing
Identification of a Novel Causal Mutation for
Eyelid Dysplasia. Elizabeth St.Germain1, K.
Tran-Viet1, T. P. Klemm5, V. Limviphuvadh2, S.
Maurer-Stroh2, 3, N. Katsanis6, Y. Shayesteh4, 7, J.
Katowitz4, 7, S. Rozen5, T. L. Young1, 5. 1Center for
Human Genetics, Duke University, Durham, NC;
2
Agency for Science Technology and Research,
Bioinformatics Institute, Singapore, Singapore;
3
School of Biological Sciences, Nanyang
Technological University, Singapore, Singapore;
4
Division of Pediatric Ophthalmology, The
Children’s Hospital of Phiadelphia, The Scheie
Eye Institute, Philadelphia, PA; 5Duke-National
University of Singapore Graduate Medical
School, Singapore, Singapore; 6Center for Human
Disease Modeling, Duke University, Durham, NC;
7
Raymond and Ruth Perelman School of Medicine,
University of Pennsylvania, Philadelphia, PA *CR
3366 — C0022 Identification of Mutations
in Candidate Genes in Patients with Globe
Anomalies: A Targeted Next-Generation
Sequencing Approach. Sushil K. Dubey1, P.
Vijayalakshmi2, S. K. Kedia3, P. Sundaresan1.
1
Genetics, Aravind Medical Research Foundation,
Madurai, India; 2Department of Pediatric
Ophthalmology, Aravind Eye Hospital, Madurai,
India; 3Laxmi Netralaya, Arrah, India
3367 — C0023 Whole Exome Sequencing
(WES) indentifies a mutation in ALPK1
responsible for a novel, autosomal dominant
disorder of vision loss, splenomegaly, and
pancytopenia. Lloyd B. Williams1, C. D. Huff4,
D. Morgan2, R. Robinson2, M. A. Morrison2,
K. Kinard2, G. Rodgers3, K. B. Digre2, M. M.
DeAngelis2. 1Cornea Department, Wilmer Eye
Center, Baltimore, MD; 2Ophthalmology, University
of Utah, Salt Lake City, UT; 3Hematology,
University of Utah, Salt Lake City, UT; 4University
of Utah, Salt Lake City, UT
3368 — C0024 Genetic diagnostic testing
in a large cohort of retinitis pigmentosa
patients using panel-based next generation
sequencing. Julia Mohr1, N. Gloeckle1, S. Kohl2,
T. Scheurenbrand1, A. Sprecher1, A. S. Bernd3,
E. Zrenner3, B. Wissinger2, K. Hörtnagel1.
1
CeGaT GmbH, Tübingen, Germany; 2Centre for
Ophthalmology, Molecular Genetics Laboratory,
University of Tübingen, Tübingen, Germany;
3
Centre for Ophthalmology, University of Tübingen,
Tübingen, Germany *CR
3369 — C0025 Highly efficient genetic
diagnostic testing in patients with inherited
retinal dystrophies using Panel-based Next
Generation Sequencing. Nicola Gloeckle1, S.
Kohl2, J. Mohr1, T. Scheurenbrand1, A. Sprecher1, S.
Biskup1, W. Berger3, 4, B. Wissinger2, J. Neidhardt3.
1
CeGaT GmbH, Tuebingen, Germany; 2Centre for
Ophthalmology, Molecular Genetics Laboratory,
University of Tuebingen, Tuebingen, Germany;
3
Institute of Medical Molecular Genetics, University
of Zurich, Zurich, Germany; 4Zurich Center for
Integrative Human Physiology (ZIHP), University
of Zurich, Zurich, Germany *CR
3370 — C0026 Inherited eye disease gene chip
study. Liping Yang. Peking university third hospital,
Beijing, China
3371 — C0027 Carriers of degenerative
retinal diseases can be easily identified using
target capture next generation sequencing.
Shirel R. Weiss1, 4, E. Eyal2, M. Salmon-Divon2, Y.
Cohen4, 5, N. Goldenberg-Cohen1, 3. 1The Krieger
Eye Research Laboratory, Felsenstein Medical
Research Center- Tel Aviv University, Petah
Tiqwa, Israel; 2Bioinformatics Laboratory, Cancer
Research Center, Chaim Sheba Medical Center,
Tel HaShomer, Ramat Gan, Israel; 3Pediatric
Ophthalmology Unit, Schneider Children’s Medical
Center of Israel, Petach Tiqwa, Israel; 4Sackler
Faculty of Medicine, Tel Aviv University, Petach
Tiqwa, Israel; 5Department of Gynecology, The
Gynecology Research Laboratory, Chaim Sheba
Medical Center, Tel HaShomer, Ramat Gan, Israel
3372 — C0028 A dual approach for
comprehensive genetic testing of ABCA4 in
Stargardt disease. Miriam Bauwens1, C. Van
Cauwenbergh1, S. De Jaegere1, S. Lefever1, B.
D’haene3, F. Pattyn1, B. P. Leroy1, 2, E. De Baere1,
F. Coppieters1. 1Center for Medical Genetics Ghent,
Ghent University, Ghent, Belgium; 2Department of
Ophthalmology, Ghent University Hospital, Ghent,
Belgium; 3Biogazelle, Ghent, Belgium
3373 — C0029 High-coverage next-generation
sequencing (NGS) for retinal dystrophies and
Usher syndrome: High diagnostic yield, CNV
detection, novel disease mechanisms and therapy
targets. Hanno J. Bolz1, 2, C. Neuhaus1, M. N.
Preising3, A. O. Khan4, M. Gliem5, P. Charbel Issa5,
U. Wolfrum6, A. Gal7, B. Lorenz3, T. Eisenberger1.
1
Center for Human Genetics, Bioscientia,
Ingelheim, Germany; 2Institute of Human Genetics,
University Hospital of Cologne, Cologne, Germany;
3
Department of Ophthalmology, Justus-LiebigUniversity Giessen, Universitätsklinikum Giessen
and Marburg GmbH, Giessen Campus, Giessen,
Germany; 4Division of Pediatric Ophthalmology,
King Khaled Eye Specialist Hospital, Riyadh, Saudi
Arabia; 5Department of Ophthalmology, University
of Bonn, Bonn, Germany; 6Cell and Matrix Biology,
Institute of Zoology, Johannes Gutenberg University
of Mainz, Mainz, Germany; 7Institute of Human
Genetics, University Medical Center HamburgEppendorf, Hamburg, Germany *CR
3374 — C0030 A Comparison of Two
Commercially Available Genetic Tests for
Age-Related Macular Degeneration. Nancy
M. Holekamp1, M. MacCumber2, A. Almony3.
1
Ophthalmology, Pepose Vision Institute, Saint
Louis, MO; 2Ophthalmology, Rush University,
Chicago, IL; 3Ophthalmology, Carolina Eye
Associates, Southern Pines, NC *CR
3375 — C0031 Evaluation of Genetic Testing
Outcomes for a 4-year Interval of Service
Provided to Southwest Eye Registry Participants.
Kaylie D. Webb, D. K. Wheaton. SW Eye Registry,
Retina Foundation of the Southwest, Dallas, TX
3376 — C0032 Positive and Unlabeled
Learning for Prioritizing Candidate Variants in
Retinal Degenerative Diseases. Alex H. Wagner1, 2,
K. Taylor2, A. P. DeLuca2, T. Casavant2, E. M.
Stone2, R. F. Mullins2, T. E. Scheetz2, T. A. Braun2.
1
Genetics, University of Iowa, Iowa City, IA;
2
Ophthalmology and Visual Sciences, University of
Iowa, Iowa City, IA *CR
3377 — C0033 A whole exome variant filtering
software for identification of disease causing
variants. Bruno Maranhao1, 2, P. Biswas2, G. A.
Silva1, 2, J. R. Heckenlively3, S. Riazuddin4, 5, P.
Lee2, R. Ayyagari2. 1Bioengineering, University
of California, San Diego, La Jolla, CA;
2
Ophthalmology, University of California, San
Diego, La Jolla, CA; 3Ophthalmology and Visual
Sciences, University of Michigan Medical School,
Ann Arbor, MI; 4National Centre for Excellence in
Molecular Biology, Lahore, Pakistan; 5Center for
Corneal Genetics, The Wilmer Eye Institute, John
Hopkins University School of Medicine, Baltimore,
MD
3378 — C0034 Detection of sample
contamination in clinical next-generation
sequencing. Todd E. Scheetz1, 2, A. P. DeLuca2,
E. M. Stone1, T. A. Braun1, 2. 1Ophthalmology,
University of Iowa, Iowa City, IA; 2Biomedical
Engineering, University of Iowa, Iowa City, IA *CR
3379 — C0035 Towards Comprehensive
Registration of DNA Sequence Variants
Associated with Inherited Retinal Diseases
in Leiden Open Variation Databases. Frans
P. Cremers1, 2, J. T. den Dunnen3, M. Ajmal1, 2,
A. Hussain2, M. I. Khan1, 2, M. N. Preising5, S.
P. Daiger6, R. Qamar2, 4. 1Department of Human
Genetics, Radboud University Medical Centre,
Nijmegen, Netherlands; 2Biosciences, COMSATS
Institute of Information Technology, Nijmegen,
Pakistan; 3Center for Human and Clinical Genetics,
Leiden University Medical Center, Leiden,
Netherlands; 4Shifa College of Medicine, Shifa
Tameer-e-Millat University, Islamabad, Pakistan;
5
Department of Ophthalmology, Justus-Liebig
University, Giessen, Germany; 6Human Genetics
Center, University of Texas Health Science Center,
Houston, TX
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
230
Tuesday – Posters – 3380 – 3396
3380 — C0036 Challenges of Microbiome
Research on the Ocular Surface. Diane L.
Smith1, 2, S. Kennedy3, R. A. Gibbs4, 5, D. B. Jones6,
C. S. De Paiva6, S. C. Pflugfelder6, J. F. Petrosino2, 7.
1
Interdepartmental Program in Translational
Biology and Molecular Medicine, Baylor College
of Medicine, Houston, TX; 2Molecular Virology
and Microbiology, Baylor College of Medicine,
Houston, TX; 3MO-BIO Laboratories, Carlsbad,
CA; 4Human Genome Sequencing Center, Baylor
College of Medicine, Houston, TX; 5Molecular
and Human Genetics, Baylor College of Medicine,
Houston, TX; 6Ophthalmology, Baylor College of
Medicine, Houston, TX; 7Center for Metagenomics
and Microbiome Research, Baylor College of
Medicine, Houston, TX *CR
3381 — C0037 Utilizing Golden Helix SVS
Software to Facilitate in the Identification
of Genes for Ocular Diseases. Khanh-Nhat
Tran-Viet1, E. St.Germain1, G. L. Peterson2,
A. Laughbaum2, V. J. Soler3, T. Yanovitch4,
S. Rozen5, T. L. Young1, 5. 1Center for Human
Genetics, Duke University, Durham, NC; 2Golden
Helix, Bozeman, MT; 3UMRS 563, Centre de
Physiopathologie de Toulouse Purpan, Université
Paul Sabatier, Toulouse, France; 4The Department
of Ophthalmology, University of Oklahoma/Dean
McGee Eye Institute, Oklahoma City, OK; 5DukeNational University of Singapore Graduate Medical
School, Singapore, Singapore *CR
3383 — C0039 The Ocular Tissue Database.
Terry A. Braun1, 5, A. H. Wagner4, 5, A. P. DeLuca3, 5,
T. Casavant3, 5, T. E. Scheetz2, 7, A. F. Clark8, 9, R. F.
Mullins2, 7, E. M. Stone6, 7. 1Ophthal/Biomed Eng,
Univ of Iowa, Iowa City, IA; 2Ophthalmology
and Visual Sciences, Univ of Iowa, Iowa City,
IA; 3Biomedical Engineering, Univ of Iowa, Iowa
City, IA; 4Genetics, Univ of Iowa, Iowa City, IA;
5
Center for Bioinformatics and Computational
Biology, Univ of Iowa, Iowa City, IA; 6Howard
Hughes Medical Institute, Univ of Iowa, Iowa
City, IA; 7Institute for Vision Research, Univ of
Iowa, Iowa City, IA; 8Department of Cell Biology
and Anatomy, Univ North Texas Health Science
Center, Fort Worth, TX; 9North Texas Eye Research
Institute, Univ North Texas Health Science Center,
Fort Worth, TX *CR
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Visual Neuroscience
342 Ganglion Cells, Visual Brain
and Behavior
Moderator: Tiffany M. Schmidt
3384 — C0105 TRPM3 expression in the
mouse retina. Robert M. Duvoisin1, W. Xiong1, B. T.
Reed1, 2, C. W. Morgans1, R. L. Brown2. 1Physiology
& Pharmacology, Oregon Health & Science
University, Portland, OR; 2VCAPP, Washington
State University, Pullman, WA
3385 — C0106 VEGF-R1 activation increases
survival of purified retinal ganglion cells. Nicolas
G. Froger1, 2, V. Forster1, 2, D. Pain1, 2, I. Ivkovic1, 2,
N. Brunel4, J. A. Sahel2, 3, S. A. Picaud1, 2. 1Insitut
de la vision, UMR_S 968 INSERM, PARIS,
France; 2Institut de la Vision, UMR_S 968 UPMC
Université Paris 06, PARIS, France; 3Institut de
Vision, CHNO des Quize-Vingts, PARIS, France;
4
Institut de recherche en santé, IFR 65, PARIS,
France *CR
3386 — C0107 Changes in retinal ganglion cell
activity in the P23H mini-swine model of retinal
degeneration. Juan P. Fernandez de Castro1,
J. Demas4, J. W. Fransen2, P. J. DeMarco3, 1, H.
J. Kaplan1, M. A. McCall1, 2. 1Ophthalmology
and Visual Sciences, University of Louisville,
Louisville, KY; 2Anatomical Science and
Neurobiology, University of Louisville, Louisville,
KY; 3Psychological and Brain Sciences, University
of Louisville, Louisville, KY; 4Biology, St Olaf
College, Northfield, MN
3387 — C0108 Toward a complete functional
classification of ganglion cells in the rat retina.
Sneha Ravi1, D. Ahn2, M. Greschner2, A. M. Litke3,
E. J. Chichilnisky2, G. D. Field4. 1Biomedical
Engineering, University of Southern California,
Los Angeles, CA; 2Systems Neurobiology
Laboratory, The Salk Institute, La Jolla, CA; 3Santa
Cruz Institute for Particle Physics, University of
California Santa Cruz, Santa Cruz, CA; 4Cell and
Neurobiology, University of Southern California,
Los Angeles, CA
3388 — C0109 Functional Classification
of Mouse Retinal Ganglion Cells. Erin
Zampaglione1, A. Ng1, J. Roebber2, D. Feldheim1,
A. Sher2. 1Molecular, Cell and Developmental
Biology, University of California Santa Cruz, Santa
Cruz, CA; 2Santa Cruz Institute for Particle Physics,
University of California Santa Cruz, Santa Cruz, CA
3389 — C0110 Cre-expressing retinal ganglion
cells in a Pcp2-Cre transgenic mouse. ChingKang J. Chen1, Y. Chen1, 5, H. Tu2, V. Chau1, A.
R. McQuiston3, C. Chiao2, 4. 1Biochemistry &
Molecular Biology, Virginia Commonwealth
University, Richmond, VA; 2Institute of Molecular
Medicine, National Tsing Hua University, Hsinchu,
Taiwan; 3Anatomy and Neurobiology, Virginia
Commonwealth University, Richmond, VA; 4Life
Science, National Tsing Hua University, Hsinchu,
Taiwan; 5Institute of Systems Neuroscience,
National Tsing Hua University, Hsinchu, Taiwan
3390 — C0111 Gap-junctions between
Populations of Ganglion and Amacrine Cells in
the Mouse Retina. Ji-Jie Pang1, D. Paul2, S. M.
Wu1. 1Ophthalmology, Baylor College of Medicine,
Houston, TX; 2Neurobiology, Harvard Medical
School, Boston, MA
3391 — C0112 Dynamic interactions between
rod and cone signaling pathways in the inner
retina. William Grimes, F. Rieke. HHMI/UofWa,
Seattle, WA
3392 — C0113 A Non-Conventional Circuit
Mechanism for the Center-Surround Receptive
Field of a Retinal Ganglion Cell. Jan Homann, M.
A. Freed. Department of Neuroscience, University
of Pennsylvania, Philadelphia, PA
3393 — C0114 Synaptic pathways underlying
spatial, contrast and temporal tuning of
parasol-Y ganglion cells in primate retina.
Joanna Crook, O. S. Packer, D. M. Dacey.
Biological Structure and the National Primate
Research Center, University of Washington, Seattle,
WA
3394 — C0115 ON-OFF DS Ganglion Cells
Detect Motion and Suppress Luminance
Responses During Natural Viewing. Maesoon
Im1, S. I. Fried1, 2. 1Department of Neurosurgery,
Massachusetts General Hospital/Harvard Medical
School, Boston, MA; 2Center of Innovative Visual
Rehabilitation, Boston VA Healthcare System,
Boston, MA
3395 — C0116 Contextual Phase Tuning of
Synaptic Inputs to Direction-selective Ganglion
Cells. Ya-Chien Chan1, S. Lee3, C. Chiao1, 2,
Z. Zhou3. 1Institute of Molecular Medicine,
National Tsing Hua University, Hsinchu, Taiwan;
2
Department of Life Science, National Tsing Hua
University, Hsinchu, Taiwan; 3Department of
Ophthalmology and Visual Science, Yale University,
New Haven, CT
3396 — C0117 Spike correlations and direction
encoding in the retina. Maxwell Turner1, J.
Zylberberg2, J. Cafaro1, E. Shea-Brown2, F.
Rieke1, 3. 1Physiology & Biophysics, University of
Washington, Seattle, WA; 2Applied Mathematics,
University of Washington, Seattle, WA; 3Howard
Hughes Medical Institute, Seattle, WA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
231
Tuesday Posters
11:00 am – 12:45 pm
3382 — C0038 Vision Variation Database
(VVD). Adam P. DeLuca1, S. Ephraim1, T. E.
Scheetz2, 1, E. M. Stone2, 3, T. A. Braun1. 1Biomedical
Engineering, University of Iowa, Iowa City,
IA; 2Department of Ophthalmology and Visual
Sciences, University of Iowa, Iowa City, IA;
3
Howard Hughes Medical Institute, Iowa City, IA
*CR
Exhibit Hall C0105-C0135
3397 – 3418 – Tuesday – Posters
3397 — C0118 Origin of the Subunit
Nonlinearity in Retinal Ganglion Cell Receptive
Fields. Bart G. Borghuis1, 2, L. L. Looger2, J. B.
Demb1. 1Ophthalmology and Visual Science, Yale
University, New Haven, CT; 2Janelia Farm Research
Campus, Howard Hughes Medical Institute,
Ashburn, VA *CR
Tuesday Posters
11:00 am – 12:45 pm
3398 — C0119 Feed-forward Inhibition
Controls Spike Onset Latency in Rabbit Local
Edge Detectors. Ilya Buldyrev, W. R. Taylor.
Casey Eye Institute, Oregon Hlth & Science Univ,
Portland, OR
3399 — C0120 Optimal waveform parameters
for extracellular activation of RGCs. Alex E.
Hadjinicolaou1, 2, C. O. Savage3, 4, D. J. Garrett5, N.
V. Apollo5, S. L. Cloherty1, 2, M. R. Ibbotson1, 6, B.
J. O’Brien1, 6. 1National Vision Research Institute,
Australian College of Optometry, Melbourne,
VIC, Australia; 2Division of Biomedical Science
and Biochemistry, Research School of Biology,
Australian National University, Canberra, ACT,
Australia; 3NeuroEngineering Laboratory,
Department of Electrical and Electronic
Engineering, University of Melbourne, Melbourne,
VIC, Australia; 4Centre for Neural Engineering,
University of Melbourne, Melbourne, VIC,
Australia; 5School of Physics, University of
Melbourne, Melbourne, VIC, Australia; 6ARC
Centre of Excellence in Vision Science, Department
of Optometry and Vision Sciences, University of
Melbourne, Melbourne, VIC, Australia
3400 — C0121 Attention enhances the
Pupillary Light Reflex. Paola Binda1, 2, M.
Pereverzeva1, S. O. Murray1. 1Psychology,
University of Washington, Seattle, WA;
2
Dipartimento Integrato Interistituzionale,
Universita’ di Pisa, Pisa, Italy
3401 — C0122 Monocular Visual Acuity
Measurement in Adult bugeye Zebrafish Using
Optokinetic Response. Faydim Rassamdana, K.
Dang, D. Cameron. Optometry, Western Univ of
Health Sciences, Pasadena, CA
3402 — C0123 Functional changes and
differential distribution of the NMDA receptors
in rd 10 mice. Abduqodir Toychiev, E. Ivanova,
C. Yee, B. T. Sagdullaev. Ophthalmology and
Neurology, Burke-Cornell Medical Research
Institute, White Plains, NY
3403 — C0124 Spatial Distribution of
Excitatory Synapses in Mouse Retinal
Ganglion Cells. Chuan-Chin Chiao1, 2, Y. Chen2, 1.
1
Department of Life Science, National Tsing Hua
University, Hsinchu, Taiwan; 2Institute of Systems
Neuroscience, National Tsing Hua University,
Hsinchu, Taiwan
3404 — C0125 Role of the NMDA receptor
coagonist D-serine in retinal function measured
with the optokinetic reflex. Manuel Esguerra,
A. L. Silberschmidt, R. F. Miller. Neuroscience,
University of Minnesota, Minneapolis, MN
3405 — C0126 Regulated NMDA signaling
in transient and sustained pathways. Santhosh
Sethuramanujam, M. Slaughter. Neuroscience,
University at Buffalo, Buffalo, NY
3406 — C0127 Synthetic conantokin peptides
potently inhibit NMDA receptor-mediated
currents of retinal ganglion cells. Luoxiu Huang1,
D. Zhang2, F. J. Castellino1. 1W.M. Keck Center for
Transgene Research, University of Notre Dame,
Notre Dame, IN; 2Eye Research Institute, Oakland
University, Rochester, MI
3407 — C0128 Assessment of Ca2+-permeable
AMPA receptor calcium dynamics in ganglion
cell layer neurons in an animal model of ocular
hypertension. Elizabeth Cairns1, M. L. Archibald3,
B. C. Chauhan2, 3, M. E. Kelly1, 2, W. H. Baldridge2,
4 1
. Pharmacology, Dalhousie University, Halifax,
NS, Canada; 2Ophthalmology & Visual Sciences,
Dalhousie University, Halifax, NS, Canada;
3
Physiology & Biophysics, Dalhousie University,
Halifax, NS, Canada; 4Anatomy & Neurobiology,
Dalhousie University, Halifax, NS, Canada
3408 — C0129 Analysis of retinal ganglion
cells projecting to the koniocellular superficial
(K1) layer of the lateral geniculate nucleus in
marmoset monkey. Kumiko A. Percival1, 2, P. R.
Martin1, 2, U. Grunert1, 2. 1Save Sight Institute, The
University of Sydney, Sydney, NSW, Australia;
2
Australian Research Council Centre of Excellence
in Vision Science, The University of Sydney,
Sydney, NSW, Australia
3409 — C0130 Principal components analysis
(PCA) of human cortical contrast response
functions reveals two dominant mechanisms: M
and P? Russell D. Hamer1, 2, G. S. Souza3, 4, T. L.
Costa1, B. D. Gomes3, L. L. Silveira3, D. F. Ventura1.
1
Departemento de Psicologia Experimental,
Instituto de Psicologia, São Paulo, Brazil; 2SmiithKettlewell Eye Research Institute, San Francisco,
CA; 3Instituto de Ciências Biológicas, Universidade
Federal do Pará, Belém, Brazil; 4Núcleo de
Medicina Tropical, Universidade Federal do Pará,
Belém, Brazil
3410 — C0131 The Awake Rabbit as a Model
For Studies of Transcranial Direct Current
Stimulation of The Visual Cortex. Thiago L.
Costa1, C. Ammann2, G. L. Ioshimoto1, A. Gruart2,
J. M. Delgado-García2, D. F. Ventura1, J. MárquezRuiz2. 1Experimental Psychology Department,
Universidade de São Paulo, São Paulo, Brazil;
2
Division of Neurosciences, Pablo de Olavide
University, Sevilla, Spain
3412 — C0133 The Relationship of Specific
Categorical Variables with PET Scan White
Matter Activation in Blind and Control
Subjects Using BrainPort. Julie M. Steinbrink1,
C. Laymon2, B. L. Rosario3, A. C. Nau4. 1School of
Medicine, University of Pittsburgh, Pittsburgh, PA;
2
Radiology, UPMC, Pittsburgh, PA; 3Epidemiology,
UPMC, Pittsburgh, PA; 4Ophthalmology, UPMC,
Pittsburgh, PA
3413 — C0134 Size-invariant shape coding
in visual area V4. Yasmine El-Shamayleh1, 2, A.
Pasupathy1, 2. 1Biological Structure, University of
Washington, Seattle, WA; 2Washington National
Primate Research Center, Seattle, WA
3414 — C0135 Imagery of a Face Enhances
Event-Related Potentials to Ambiguous Visual
Stimuli. Lingxi Lu1, 3, Y. Tian2, 3, T. Huang2, 3,
X. Wu2, 3, W. Gao2, 3, L. Li1, 3. 1Department of
Psychology, Peking University, Beijing, China;
2
School of Electronics Engineering and Computer
Science, Peking University, Beijing, China; 3Key
Laboratory on Machine Perception (Ministry of
Education), Peking University, Beijing, China
Exhibit Hall C0136-C0148
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Visual Neuroscience
343 Circadian and Adaptational
Modulation
Moderator: Christophe Ribelayga
3415 — C0136 Retinal CLOCK and
NPAS2: Differential Expression, Circadian
Gene Regulation, and Roles in Visual
Function. Christopher K. Hwang, P. M. Iuvone.
Ophthalmology, Emory University School of
Medicine, Atlanta, GA
3416 — C0137 On-Off Direction-Selective
Retinal Ganglion Cells Co-Express CART and
NPAS2, a Circadian Clock Protein. S. Anna
Sargsyan, C. K. Hwang, P. M. Iuvone. Emory
University, Atlanta, GA
3417 — C0138 Light-dark Condition Regulates
Sirtuin Genes in the Retina. Norimitsu Ban1, 2,
T. Inaba2, S. Miyake1, K. Tsubota2, Y. Ozawa1, 2.
1
Laboratory of Retinal cell biology, Keio University,
Tokyo, Japan; 2Department of Ophthalmology, Keio
University, Tokyo, Japan *CR
3418 — C0139 Diurnal Effects on Pupil Size of
Unrestrained WT Mice and Mice Lacking Rod
or Cone Function. Franklin Naarendorp, C. Van
Slyck. Northeastern University, Boston, MA
3411 — C0132 High-Throughput Visual Acuity
Device for Rats: Training and Development.
Jeffrey A. Jamison1, 2, S. Baron1, T. S. Vihtelic2.
1
Ophthy-DS, Inc, Mattawan, MI; 2MPI Research,
Mattawan, MI *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
232
Tuesday – Posters – 3419 – 3441
3419 — C0140 Circadian rhythm of
electroretinograms in living zebrafish
larvae. Hisashi Matsubara1, T. Tanaka2, Y.
Nishimura2, Y. Matsui1, T. Yamamoto3, M. Kondo1.
1
Ophthalmology, Mie University Graduate School
of Medicine, Tsu, Japan; 2Department of Molecular
and Cellular Pharmacology, Pharmacogenomics
and Pharmacoinformatics, Mie University
Graduate School of Medicine, Tsu, Japan; 3System
Physiology, Mie University Graduate School of
Medicine, Tsu, Japan
3420 — C0141 Turnover rate of the neuronal
connexin Cx36 in HeLa cells. Yanran Wang1, 2, J.
O’Brien1, 2. 1Vision and Ophthalmology, University
of Texas Health Science Center Houston, Houston,
TX; 2Neuroscience, The University of Texas
Graduate School of Biomedical Sciences, Houston,
TX
3421 — C0142 Dopamine differentially affects
network light adaptation in ON- and OFF-center
transient retinal ganglion cells. Michael L. Risner,
C. R. Jackson, D. McMahon. Biological Sciences,
Vanderbilt University, Nashville, TN
3422 — C0143 Light adaptation alters the
spatial distribution of inhibition to the retinal
OFF pathway. Reece Mazade1, E. D. Eggers1, 2.
1
Physiology, University of Arizona, Tucson, AZ;
2
Biomedical Engineering, University of Arizona,
Tucson, AZ
3424 — C0145 Investigating circadian rhythms
in mouse retinal dopaminergic amacrine
neurons. Heng Dai, D. McMahon. Biological
Sciences, Vanderbilt University, Nashville, TN
3425 — C0146 Seeking For Circadian
Rhythmicity in the Mammalian Photoreceptor
Visual Cycle. Yunlu Xue2, 1, V. J. Kefalov1. 1Ophthal
& Visual Sciences, Washington University in St
Louis, St Louis, MO; 2Neuroscience Program,
Division of Biological and Biomedical Sciences,
Washington University in St Louis, St. Louis, MO
3426 — C0147 Optic nerve involvement in
relation to rest-activity circadian rhythm in
Alzheimer’s disease. Chiara La Morgia1, 2, R.
Gallassi1, L. Sambati1, 2, F. Provini1, 2, P. Barboni3,
V. Carelli1, 2. 1Department of BioMedical and
NeuroMotor Sciences, University of Bologna,
Bologna, Italy; 2IRCCS Neurological Institute
of Bologna, Bologna, Italy; 3Studio Oculistico
d’Azeglio, Bologna, Italy
3427 — C0148 Die Fledermaus: In Retinal
Light-Adaptation, Chicks Are Mice With Wings.
Qing Shi1, W. K. Stell2, 3. 1Neuroscience, University
of Calgary, Hotchkiss Brain Institute, Calgary, AB,
Canada; 2Cell Biology and Anatomy, University of
Calgary, Hotchkiss Brain Institute, Calgary, AB,
Canada; 3Surgery, University of Calgary, Calgary,
AB, Canada
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Visual Psychophysics / Physiological Optics
344 Cones and Outer Retina
Moderators: Nathan Doble and Adam Boretsky
3428 — C0149 Photoreceptor Pointing as a
Function of Retinal Eccentricity in Normal
Human Eyes. Nathan Doble1, R. Kivlin1, J. L.
Codona2, S. Li3, S. S. Choi1. 1Vision Science, New
England College of Optometry, Boston, MA;
2
Steward Observatory, University of Arizona
College of Optical Sciences, Tuscon, AZ; 3Retina
Foundation of the Southwest, Dallas, TX *CR
3429 — C0150 The role of defocus on
photoreceptor light coupling analyzed with
a waveguide-based retinal simulator. Brian
Vohnsen1, D. Rativa Millan2, C. Vela1, B. Lochocki1,
P. B. Kruger3. 1School of Physics, University
College Dublin, Dublin, Ireland; 2Pós-Graduação
em Engenharia de Sistemas (PPGES), Universidade
de Pernambuco, Recife, Brazil; 3College of
Optometry, State University of New York, New
York, NY
3430 — C0151 Measurement of the
Photoreceptor Pointing in the Living Chick Eye.
Maria Walker, R. Kivlin, N. Doble. Vision Science,
New England College of Optometry, Boston, MA
*CR
3431 — C0152 Reproducibility of the rtx1
adaptive optics retinal camera. Dirk-Uwe G.
Bartsch, C. Arcinue, F. Ma, L. Cheng, W. Freeman.
Ophthalmology-Shiley Eye Ctr, Univ of CaliforniaSan Diego, La Jolla, CA *CR
3432 — C0153 Test-Retest Reliability of
Microperimetry Using the Optos OCT SLO in
Eyes With and Without Known Retinal Diseases.
Hyun Soo Jang, Y. J. Sepah, M. G. Bittencourt, M.
A. Sadiq, O. O. Agbedia, H. Liu, M. Ansari, Z. S.
Rentiya, D. A. Ferraz, Q. Nguyen. Retinal Imaging
Research and Reading Center, Wilmer Eye Institute,
Johns Hopkins University, Baltimore, MD *CR
3433 — C0154 Assessing retinal detailed
structure in pathological myopia with adaptive
optics scanning laser ophthalmoscope. Na Liao,
C. Li, Y. Li, H. Chen, Q. Wang. Wenzhou Medical
College, WenZhou, China
3434 — C0155 Variation of cone density
assessed by Adaptive Optics Retinal Camera
with axial length. Meillat mMathieu, P. Tumahai,
M. Bidaut-Garnier, G. Debellemaniere, M.
Flores, M. Montard, B. Y. Delbosc, M. Saleh.
ophthalmology, besancon hospital jean minjoz,
Besancon, France
3435 — C0156 Quantification and Comparison
of Cone density, Outer Nuclear Layer and
Henle’s Fiber Layer Thickness Using HighResolution Imaging. Grace K. Han1, J. T. Bayabo2,
B. J. Lujan2, 3, J. I. Morgan1. 1Scheie Eye Institute
of Opthalmology, University of Pennsylvania,
Philadelphia, PA; 2Vision Science, University
of California, Berkeley, CA; 3West Coast Retina
Medical Group, San Francisco, CA *CR
3436 — C0157 Correlation of outer nuclear
layer thickness with cone density values in
patients with retinitis pigmentosa and healthy
subjects. Moreno Menghini1, B. J. Lujan2,
S. Zayit-Soudry1, R. Syed1, T. Porco1, J. T.
Bayabo2, J. Carroll3, A. Roorda2, J. L. Duncan1.
1
Ophthalmology, University of California
San Francisco, San Francisco, CA; 2School of
Optometry, University of California Berkeley,
Berkeley, CA; 3Ophthalmology, Medical College of
Wisconsin, Milwaukee, MI *CR, f
3437 — C0158 Repeatability of Cone Density
Measurements in Healthy Subjects Using
Commercially Available Flood-Illuminated
Adaptive Optics. Shu Feng, A. K. Garg, A. Faridi,
J. D. Fay, H. E. Titus, T. B. Smith, K. V. Michaels,
M. E. Pennesi. Casey Eye Institute, Oregon Health
& Sciences University, Portland, OR *CR
3438 — C0159 High resolution imaging of
photoreceptors in healthy humans of different
ages eyes using RTX-1 ™ Adaptive Optics
Retinal camera. Perle tumahai, M. mathieu, M.
Bidaut-Garnier, G. Debellemaniere, M. Flores, M.
Montard, B. Y. Delbosc, M. Saleh. Ophthalmology,
University Hospital of Besançon, Besançon, France
3439 — C0160 Quantitative analysis of cone
photoreceptor distribution in aged patients
using an adaptive optics fundus camera. Ryo
Obata1, X. Tan1, K. Kure1, F. Rosander2, Y. Yanagi1.
1
Department of Ophthalmology, The University of
Tokyo, Tokyo, Japan; 2Department of Biomedical
Engineering, Medical Informatics, Linköping
University, Linköping, Sweden *CR
3440 — C0161 Reproducibility of
photoreceptor imaging by Adaptive Optics
Retinal Camera. Mélanie Bidaut-Garnier1,
M. Flores1, P. Tumahai1, M. Mathieu1, G.
Debellemaniere1, M. Puyraveau2, B. Y. Delbosc1,
M. Montard1, M. Saleh1. 1Department of
Ophthalmology, University Hospital of Besançon,
Besançon, France; 2Methodology center, Besançon,
France
3441 — C0162 Analysis of the Photoreceptor
Mosaic in Patients with Each Stage of Dry
Age-Related Macular Degeneration (AMD):
Cone Density and Spacing as Image-Based
Biomarkers. Adam Boretsky1, F. Khan1, F.
J. van Kuijk2, M. Motamedi1. 1Center for
Biomedical Engineering, Univ of Texas Medical
Branch, Galveston, TX; 2Ophthalmology and
Visual Neuroscience, University of Minnesota,
Minneapolis, MN
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
233
Tuesday Posters
11:00 am – 12:45 pm
3423 — C0144 Photoperiod Dependence of the
Mouse Retinal Dopaminergic System. Zhijing
Zhang1, G. C. Hopping2, X. Liu1, C. Ribelayga1.
1
Ophthalmology & Visual Science, UT Health
- Med School, Houston, TX; 2Undergraduate
Program, Rice University, Houston, TX
Exhibit Hall C0149-C0176
3442 – 3462 – Tuesday – Posters
3442 — C0163 High Resolution Imaging with
Adaptive Optics in Patients with Vogt-Koyanagi
Harada Disease. Kiyoko Gocho, S. Kikuchi, T.
Kabuto, H. Takahashi, S. Kameya, K. Yamaki, H.
Takahashi. Ophthalmology, Nippon Med Univ,
Chiba Hokusoh Hosp, Inzai, Japan
3443 — C0164 Spectral-Domain Optical
Coherence Tomographic Findings in Acute Zonal
Occult Outer Retinopathy (AZOOR)-complex at
Initial Visit to the Hospital. Yoshitsugu Matsui1,
M. Miyata1, H. Matsubara1, S. Ueno2, S. Kachi2,
Y. Ito2, H. Terasaki2, M. Kondo1. 1Opthalmology,
Mie University Graduate School of Medicine, Tsu,
Japan; 2Opthalmology, Nagoya University Graduate
School of Medicine, Nagoya, Japan
Tuesday Posters
11:00 am – 12:45 pm
3444 — C0165 Evidence of Retinal Damage in
Chloroquine/Hydroxychloroquine Maculopathy
as Revealed by High Resolution Imaging: A
Case Report Utilizing Adaptive Optics Scanning
Laser Ophthalmoscopy. SongEun Lee1, S. Park1, 2,
E. Bae2, S. H. Tsang1, S. Chang1. 1Ophthalmology,
Harkness Eye Institute, Columbia University, New
York, NY; 2Ophthalmology, Kangdong Sacred Heart
Hospital, Hallym University Medical Center, Seoul,
Republic of Korea *CR
3445 — C0166 Adaptive Optics Scanning
Laser Ophthalmoscopy and High Resolution
Imaging in Autosomal Dominant Retinitis
Pigmentosa Caused by a Novel PRPF31
Nonsense Mutation. Jessica I. Morgan1, 2, M.
Sivalingam1, G. K. Han1, A. M. Maguire1, 2, B. J.
Forbes1, 2, X. Gai3, E. A. Pierce4, J. Bennett1, 2,
D. C. Chung1, 2. 1Ophthalmology, University of
Pennsylvania, Philadelphia, PA; 2Ophthalmology,
Children’s Hospital of Philadelphia, Philadelphia,
PA; 3Molecular Pharmacology and Therapeutics,
Loyola University Chicago, Chicago, IL; 4Ocular
Genomics Institute, Department of Ophthalmology,
Massachusetts Eye and Ear Infirmary, Harvard
Medical School, Boston, MA *CR
3446 — C0167 Cone Abnormalities in
Fundus Albipunctatus Associated with RDH5
Mutation Using Adaptive Optics Scanning Laser
Ophthalmoscopy. Sotaro Ooto, Y. Makiyama,
M. Hangai, K. Ogino, N. Gotoh, A. Oishi, N.
Yoshimura. Ophthalmology & Visual Sciences,
Kyoto University Graduate School of Medicine,
Kyoto, Japan *CR
3447 — C0168 Adaptive Optics Scanning
Laser Ophthalmoscopy and Multi-Modality
Clinical Imaging in a Patient with Gyrate
Atrophy. Eva S. Klinman1, A. M. Maguire2, G. K.
Han2, J. I. Morgan2. 1Neuroscience, University of
Pennsylvania School of Medicine, Philadelphia,
PA; 2Scheie Eye Institute Department of
Ophthalmology, University of Pennsylvania School
of Medicine, Philadelphia, PA *CR
3448 — C0169 Cellular Imaging Demonstrates
Genetic Mosaicism in Heterozygous Carriers of
an X-Linked Ciliopathy Gene. Sung Pyo Park1, 2,
I. Hong2, W. Lee1, M. Marsiglia1, T. Kitamura4, S.
H. Tsang1, 3, S. Chang1. 1Ophthalmology, Columbia
University Medical Center, New York, NY;
2
Ophthalmology, Kangdong Sacred Heart Hospital,
Hallym University Medical Center, Seoul, Republic
of Korea; 3Pathology & Cell Biology, Columbia
University Medical Center, New York, NY; 4Canon
Inc., Tokyo, Japan *CR
3455 — C0176 High resolution cone
photoreceptor imaging analysis of an occult
macular dystrophy patient with RP1L1 mutation.
Shuhei Kameya1, T. Kabuto1, S. Kikuchi1, H.
Takahashi1, K. Gocho1, K. Yamaki1, H. Takahashi2.
1
Ophthalmology, Chiba Hokusoh Hosp Nippon Med
Sch, Inzai, Japan; 2Ophthalmology, Nippon Medical
School, Tokyo, Japan
3449 — C0170 Disruption of the Human Cone
Photoreceptor Mosaic from a Defect in NR2E3
Transcription Factor Function. Frank S. Siringo1,
S. Park1, 2, I. Hong2, S. H. Tsang1, 3, W. Lee1, J.
Horowitz1, R. Allikmets1, S. Chang1, S. Yzer4, 1.
1
Ophthalmology, Columbia University Medical
Center, Fort Lee, NJ; 2Ophthalmology, Kangdong
Sacred Heart Hospital, Hallym University Medical
Center, Seoul, Republic of Korea; 3Pathology &
Cell Biology, Columbia University Medical Center,
New York, NY; 4Ophthalmology, Rotterdam Eye
Hospital, Rotterdam, Netherlands *CR
Tuesday, May 07, 2013 11:00 AM-12:45 PM
3450 — C0171 Cellular Imaging after
Remission from Diabetic Macular Edema.
Ching-Lung Chen1, 2, S. Park1, 3, T. Kitamura4, S.
Chang1. 1OPhthalmology, Columbia university
medical center, New york, NY; 2Department of
Ophthalmology, Chang Gung Memorial Hospital,
Chiayi, Taiwan; 3Department of Ophthalmology,
Hallym University Medical Center, Seoul, Republic
of Korea; 4Healthcare Solutions Division, Canon,
New york, NY *CR
3451 — C0172 Photoreceptor Structure
in Presumed Non-Neoplastic Autoimmune
Retinopathy. David B. Kay1, R. F. Cooper2, D.
H. Scoles3, F. R. Zakka1, V. Williams1, A. Dubra1, 4,
J. Carroll1, 4, K. E. Stepien1. 1Department of
Ophthalmology, Medical College of Wisconsin,
Milwaukee, WI; 2Department of Biomedical
Engineering, Marquette University, Milwaukee, WI;
3
Department of Biomedical Engineering, University
of Rochester, Rochester, NY; 4Department of
Biophysics, Medical College of Wisconsin,
Milwaukee, WI *CR
3452 — C0173 Cone photoreceptors at the
fovea after serous retinal detachment observed
with adaptive optics fundus camera (rtx1).
Atsushi Hayashi, T. Nakamura, N. Tojo, T. Ueda, T.
Oiwake, A. Miyakoshi, H. Ozaki. Ophthalmology,
University of Toyama, Toyama, Japan
3453 — C0174 Evaluation of cone density after
retinal detachment surgery using an Adaptive
Optics camera. Maher Saleh, M. mathieu, M.
Bidaut-Garnier, P. Tumahai, G. Debellemaniere, M.
Flores, M. Montard, B. Y. Delbosc. Ophthalmology,
University Hospital of Besançon, Besançon, France
3454 — C0175 Recovery of photoreceptors
in the macula of idiopathic choroidal
neovascularization observed with adaptive optics
fundus camera. Tomoko Nakamura, T. Oiwake,
T. Ueda, A. Miyakoshi, A. Hayashi. University of
Toyama, Toyama, Japan
Exhibit Hall D0083-D0108
Cornea
345 Corneal Surgery Non-refractive II
and Keratoprosthesis
Moderators: Mary K. Daly and Mark R. Wilkins
3456 — D0083 A Prospective Trial Evaluating
Scleral Rebound Tonometry. Shuchi B. Patel, S. L.
Duke, A. Logeman. Ophthalmology, University of
Chicago, Maywood, IL
3457 — D0084 Limbal and Scleral
Pneumatonometer versus Manometric
Reading in Cadaver Eyes with Type 1 Boston
Keratoprosthesis. Janet M. Lim, G. Bang, T. S.
Vajaranant, A. A. Aref, M. S. Cortina, J. De la Cruz.
Illinois Eye and Ear Infirmary, UIC Department of
Ophthalmology and Visual Sciences, Chicago, IL
*CR
3458 — D0085 Analysis of Eyes Undergone
Boston Keratoprosthesis transplantation
Using Anterior Segment Optical Coherence
Tomography. Yumiko HIrayama, N. Toriyama,
D. Tomida, K. Konomi, Y. Satake, J. Shimazaki.
Ichikawa General Hospital Tokyo Dental Collage,
Ichikawa, Japan *CR, f
3459 — D0086 Boston type 1 keratoprosthesis:
surgical indications, short term retention and
achievement of 20/200 vision. Kristine Lo, K.
Colby, J. Chodosh. Massachusetts Eye and Ear
Infirmary, Boston, MA *CR
3460 — D0087 The Boston Keratoprosthesis
Type I in Mucous Membrane Pemphigoid. Sotiria
Palioura1, B. Kim2, C. H. Dohlman1, J. Chodosh1.
1
Ophthalmology, Massachusetts Eye & Ear Infirm,
Boston, MA; 2Ophthalmology, University of Illinois
at Chicago, Chicago, IL *CR
3461 — D0088 Prosthetic Replacement of
the Ocular Surface Ecosystem (PROSE) for
Visual Rehabilitation in Patients with Corneal
Ectasia. Nadeem H. Fatteh, K. Deloss, C. T. Hood.
Ophthalmology, University of Michigan, Ann
Arbor, MI
3462 — D0089 Risk Factors Associated
with Cystoid Macular Edema After Boston
Keratoprosthesis Type 1 Implantation. Kaitlyn M.
Wallace, J. H. Hou, R. C. Miller, C. C. Chow, J. De
la Cruz, F. Y. Chau, M. S. Cortina. UIC Department
of Ophthalmology and Visual Sciences, Illinois Eye
and Ear Infirmary, Chicago, IL *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
234
Tuesday – Posters – 3463 – 3481
3463 — D0090 In vivo evaluation of microbial
infection on surface functionalized titanium
as artificial cornea candidate material. XiaoWei Tan1, R. Lakshminarayanan1, G. Goh1, M.
Setiawan1, S. Liu1, R. W. Beuerman1, 2, D. T. Tan3, 4,
J. S. Mehta1, 3. 1Singapore Eye Research Institute,
Singapore, Singapore; 2Yong Loo Lin School
of Medicine, National University of Singapore,
Singapore, Singapore; 3Singapore National Eye
Centre, Singapore, Singapore; 4Department of
Clinical Sciences, Duke-NUS Graduate Medical
School, Singapore, Singapore *CR
3464 — D0091 Bandage CL fitting
characteristics and complications in patients
with Boston Type I keratoprosthesis surgery.
Ellen Shorter, C. E. Joslin, T. T. McMahon, J. De
la Cruz, M. S. Cortina. University of Illinois at
Chicago, Chicago, IL *CR
3465 — D0092 Keratoprosthesis Imaging
Using Anterior Segment Optical Coherence
Tomography to Detect Graft Host Defects in
the Clinic and in the Operating Room. Mark
N. Welch, M. Banitt, A. M. Berrocal, V. L. Perez.
Ophthalmology, Bascom Palmer Eye Institute,
Miami, FL *CR
3467 — D0094 Scanning Laser
Ophthalmoscope Microperimetry through
the Boston Keratoprosthesis. Rony R. Sayegh,
C. H. Dohlman, M. Jackson. Ophthalmology,
Massachusetts Eye & Ear Infirmary, Boston, MA
3468 — D0095 Assessment of Titanium
Modification for Coloring the Backplate
of Boston Keratoprosthesis. Eleftherios I.
Paschalis1, 2, J. Chodosh1, S. J. Spurr-Michaud2, A.
Cruzat1, A. Tauber1, I. Behlau1, I. K. Gipson2, C. H.
Dohlman1. 1Ophthalmology, Massachusetts Eye and
Ear Infirmary - Harvard Medical School, Boston,
MA; 2Ophthalmology, Schepens Eye Research
Institute - Harvard Medical School, Boston, MA
*CR
3469 — D0096 Femto-second-laser and eximerlaser assisted preparation of biosynthetic corneal
collagen donor implants and the recipient bed.
Raphael T. Neuhann1, K. M. Wand1, K. Kobuch1, M.
Baumann4, M. Griffith2, M. M. Islam2, J. Junger4,
R. Ritter3, C. Lohmann1. 1Ophthalmology, Klinkum
Rechts der Isar, Munich, Germany; 2Regenerative
Medicine, Linkoping University, Linkoping,
Sweden; 3Technolas Perfect Vision, Munich,
Germany; 4MLase AG, Germering, Germany *CR
3471 — D0098 Improvement of the water
tightness of a monobloc keratoprosthesis with
the use of a surgical bio-glue. Preliminary results
in dogs. Pierre F. Isard1, M. Mentek2, T. Dulaurent1.
1
Centre Hospitalier Vétérinaire Saint-Martin,
Saint-Martin Bellevue, France; 2INSERM U1042,
Grenoble, France
3472 — D0099 Agreement among
Transpalpebral, Transcleral and Tactile
Intraocular Pressure Measurements in Eyes
with Type 1 Boston Keratoprosthesis. Jessica L.
Liu, T. S. Vajaranant, M. S. Cortina, J. T. Wilensky.
Glaucoma, University of Illinois at Chicago,
Chicago, IL
3473 — D0100 Retinal Detachments in Eyes
After Boston Keratoprosthesis Type 1. Sachin
Jain, C. C. Chow, J. I. Lim, L. J. Ulanski, J. De la
Cruz, M. S. Cortina, F. Y. Chau. Illinois Eye and Ear
Infirmary. UIC Department of Ophthalmology and
Visual Sciences, University of Illinois, Chicago, IL
*CR
3474 — D0101 Implantation of Biosynthetic
Collagen III Corneal Implants in vivo in
Rabbit Eyes: Surgical Technique and Clinical
Performance. Karin Kobuch1, R. T. Neuhann1, K.
Wand1, J. Junger3, M. Baumann3, R. Ritter4, M. M.
Islam2, M. Griffith2, C. Lohmann1. 1Ophthalmology,
Technische Universität Muenchen, Klinikum
rechts der Isar, Munich, Germany; 2Regenerative
Medicine, University of Linkoeping, Linkoeping,
Sweden; 3MLase, Munich, Germany; 4Technolas
PV, Munich, Germany *CR
3475 — D0102 The effect of the presence of
preoperative silicone oil, absence of prior corneal
surgery, and postoperative scleral contact
lens use on Boston keratoprosthesis outcomes.
Kareem Moussa1, J. Petrowski1, N. A. Afshari2.
1
Duke Eye Center, Duke University, Durham, NC;
2
Shiley Eye Center, University of California, San
Diego, La Jolla, CA
3477 — D0104 Chondro-ocular graft transfer::
An alternative to allograft transplantation?
David Myung1, C. N. Ta1, E. Yung2, C. W. Frank3.
1
Ophthalmology, Stanford University School of
Medicine, Byers Eye Institute, Palo Alto, CA;
2
Santa Clara Valley Medical Center, Santa Clara,
CA; 3Chemical Engineering, Stanford University,
Stanford, CA *CR
3478 — D0105 Polydopamine-coated and
polyethylene glycol-impregnated corneas as
tissue carriers for the Boston Keratoprosthesis.
Sara Bozorg1, K. Jeong2, S. N. Arafat1, D.
S. Kohane2, C. H. Dohlman1. 1Department
of Ophthalmology, Massachusetts Eye and
Ear Infirmary, Boston, MA; 2Department of
Anesthesiology, Division of Critical Care Medicine,
Children’s Hospital Boston, Harvard Medical
School, Boston, MA
3479 — D0106 Designing a Novel Porous
Keratoprosthesis to Promote Cornea Cell
Ingrowth. Amelia L. Zellander1, R. A. Gemeinhart2,
B. Milani3, A. R. Djalilian3, M. Makhsous4, M.
Cho1. 1Bioengineering, University of Illinois at
Chicago, Chicago, IL; 2Biopharmaceutical Sciences,
University of Illinois at Chicago, Chicago, IL;
3
Ophthalmology and Visual Sciences, University of
Illinois at Chicago, Chicago, IL; 4Physical Medicine
and Human Movement Sciences, Northwestern
University, Chicago, IL *CR
3480 — D0107 A fish scale-derived scaffold
for corneal reconstruction. T H. van Essen1, S.
J. Sparks2, L. van Zijl2, G. Chen3, C. C. Lin3, H. J.
Lai3, G. P. Luyten1, A. El Ghalbzouri2, M. J. Jager1.
1
Ophthalmology, Leiden Univ Medical Center,
Leiden, Netherlands; 2Dermatology, Leiden Univ
Medical Center, Leiden, Netherlands; 3Research,
Aeon Astron Europe B.V., Leiden, Netherlands *CR
3481 — D0108 Improvements in the Modified
Osteo-Odonto Keratoprosthesis (MOOKP)
Surgery Technique. Mariela C. Aguilar1, Y.
Sawatari2, A. Gonzalez1, W. Lee1, C. J. Rowaan1,
D. Sathiah2, D. Miller3, V. L. Perez3, E. C. Alfonso3,
J. A. Parel1. 1Ophthalmic Biophysics Center,
Department of Ophthalmology, Bascom Palmer
Eye Institute, University of Miami Miller School of
Medicine, Miami, FL; 2Oral Maxillofacial Division,
Department of Surgery, University of Miami Miller
School of Medicine, Miami, FL; 3Department of
Ophthalmology, Bascom Palmer Eye Institute,
University of Miami Miller School of Medicine,
Miami, FL *CR
3476 — D0103 Evaluation Of The Interface
Between Keratoprosthesis and Donor Cornea
By Anterior Segment OCT. Riccardo Scotto, M.
Papadia, A. Bagnis, C. Traverso. Ophthalmology,
DiNogmi, University of Genoa, Genova, Italy *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
235
Tuesday Posters
11:00 am – 12:45 pm
3466 — D0093 Anterior Segment Optical
Coherence Tomography in Patients with
Boston Type I Keratoprosthesis Allows Early
Detection and Monitoring of Corneal and
Scleral Melts. David Sola-Del Valle1, B. M.
Cavalcanti1, 2, A. Cruzat1, 2, C. H. Dohlman1, P.
Hamrah1, 2. 1Ophthalmology - Cornea & Refractive
Surgery Service, Massachusetts Eye & Ear
Infirmary, Harvard Medical School Department of
Ophthalmology, Boston, MA; 2Ophthalmology:
Ocular Surface Imaging Center, Massachusetts
Eye & Ear Infirmary, Harvard Medical School
Department of Ophthalmology, Boston, MA
3470 — D0097 Imaging of Surface Defects and
Biofilm Formation of Extruded Keratoprostheses
Using Confocal Microscopy. Heather A.
Durkee1, 4, D. Miller2, V. L. Perez2, Y. Sawatari3, A.
V. Rachitskaya2, A. M. Berrocal2, E. C. Alfonso2,
J. A. Parel1, 2. 1Ophthalmic Biophysics Center,
Bascom Palmer Eye Institute, University of
Miami Miller School of Medicine, Miami, FL;
2
Department of Ophthalmology, Bascom Palmer
Eye Institute, University of Miami Miller School of
Medicine, Miami, FL; 3Department of Maxillofacial
Surgery, University of Miami Miller School of
Medicine, Miami, FL; 4Department of Biomedical
Engineering, College of Engineering, University of
Miami, Coral Gables, FL *CR
3482 – 3503 – Tuesday – Posters
Exhibit Hall D0158-D0201
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Clinical/Epidemiologic Research
346 Glaucoma
Moderator: Kuldev Singh
3482 — D0158 Glaucoma and artificial tears.
Rodrigo M. Torres1, 2, P. G. Lodolo1. 1Ocular Surface
& Immunology, Centro de Ojos Dr Lodolo, Parana,
Entre Rios, Argentina; 2Basic & Clinical Research,
ROMAT, Colonia Avellaneda, Entre Rios, Argentina
3483 — D0159 Which Scheimpflug parameters
are most predictive in detecting narrow
anterior chamber angles? Afsun Sahin, Z. Usalp,
N. Yildirim, Bolluk, A. Özer. Department of
Ophthalmology, Eskisehir Osmangazi University
Medical School, Eskisehir, Turkey
Tuesday Posters
11:00 am – 12:45 pm
3484 — D0160 Factors associated with
the onset of treatment in fellow eyes in the
Collaborative Initial Glaucoma Treatment Study.
David C. Musch1, 2, L. M. Niziol1, B. W. Gillespie3.
1
Ophthalmology & Visual Sciences, Univ of
Michigan, Ann Arbor, MI; 2Epidemiology, Univ of
Michigan, Ann Arbor, MI; 3Biostatistics, Univ of
Michigan, Ann Arbor, MI *CR, f
3485 — D0161 Measures of Intraocular
Pressure Variation and Risk of Developing Openangle Glaucoma: The Los Angeles Latino Eye
Study. Xuejuan Jiang1, 2, R. Varma1, 2, M. Torres1,
S. P. Azen2, B. A. Francis1, V. Chopra1, B. Nguyen1.
1
Doheny Eye Institute, University of Southern
California, Los Angeles, CA; 2Preventive Medicine,
University of Southern California, Los Angeles,
CA *CR
3486 — D0162 The African Descent and
Glaucoma Evaluation Study (Adages):
Predictors Of Glaucoma Progression in
Glaucoma Suspects. Naira Khachatryan1, A.
Miki1, S. Jain2, F. He2, N. Hammel1, F. A. Medeiros1,
R. N. Weinreb1, J. M. Liebmann3, 4, C. A. Girkin5,
L. M. Zangwill1. 1Hamilton Glaucoma Center,
Department of Ophthalmology, University of
California, San Diego, La Jolla, CA; 2Department
of Family and Preventive Medicine, University of
California, San Diego, La Jolla, CA; 3Department
of Ophthalmology, New York University School
of Medicine, New York, NY; 4Department of
Ophthalmology, Einhorn Clinical Research Center,
New York Eye and Ear Infirmary, New York, NY;
5
Department of Ophthalmology, University of
Alabama at Birmingham, Birmingham, AL *CR, f
3487 — D0163 Baseline Prognostic Factors
Predict Rapid Progression. Jun Mo Lee1, J.
Caprioli1, K. Nouri-Mahdavi1, A. Afifi2, E. Morales1,
M. Ramanathan1, F. Yu1, 2, A. L. Coleman1, 3.
1
ophthalmology, Jules Stein Eye Institute, UCLA,
Los Angeles, CA; 2biostatistics, School of public
health at UCLA, los angeles, CA; 3epidemiology,
School of public health at UCLA, los angeles, CA
*CR
3488 — D0164 A Korea National Health and
Nutrition Examination Survey (KNHANES)
(2009-2010)-based analysis of intraocular
pressure and associated systemic factors
in a Korean population. Mi Jeung Kim1, 2,
K. Park1, 2, J. Jeoung1, 2, S. Kim1, 3, Y. Choi2,
K. Kim2. 1Ophthalmology, Seoul National
University College of Medicine, Seoul, Republic
of Korea; 2Ophthalmology, Seoul National
University Hospital, Seoul, Republic of Korea;
3
Ophthalmology, Seoul National University
Boramae Hospital, Seoul, Republic of Korea
3489 — D0165 The association of Diurnal
Intraocular Pressure (DIOP) fluctuation and
anterior chamber angle dimensions in patients
with primary angle closure, and the association
with peripheral anterior synechiae (PAS): The
Investigating Management of Angle Closure
and Treatment (IMPACT) study. Laura Sanchez
Parra1, R. Buckley1, S. Pardhan1, R. R. Bourne1, 2.
1
Vision & Eye Research Unit, Postgraduate Medical
Institute, Anglia Ruskin University, Cambridge,
United Kingdom; 2Huntingdon Glaucoma &
Diagnostic Research Centre, Hinchingbrooke
Hospital, Huntingdon, United Kingdom *CR, f
3490 — D0166 Female Reproductive Factors
and Major Eye Diseases in Asian Women - The
Singapore Malay Eye Study. Janice Lam1, 2, W.
Tay1, T. Aung1, 3, S. Saw1, 4, T. Y. Wong1, 2. 1Singapore
Eye Research Institute, Singapore National Eye
Centre, Singapore, Singapore; 2Department of
Ophthalmology, National University Health System
(NUHS), Singapore, Singapore; 3Department
of Ophthalmology, Yong Loo Lin School of
Medicine, National University of Singapore,
Singapore, Singapore; 4Department of Community,
Occupational and Family Medicine, Yong Loo
Lin School of Medicine, National University of
Singapore, Singapore, Singapore *CR
3491 — D0167 Cost of glaucoma in the XXI
century. Economic Analysis. Gabriel LazcanoGomez, J. Jimenez-Roman. GLAUCOMA, APEC,
Cuautitlan Izcalli, Mexico
3492 — D0168 Association between Thyroid
Conditions and Open-Angle Glaucoma in the
United States Medicare Population. Judy L.
Chen1, 2, F. Yu1, F. Lum1, A. L. Coleman1. 1Jules Stein
Eye Institute, Los Angeles, CA; 2David Geffen
School of Medicine at UCLA, Los Angeles, CA
3493 — D0169 Normal tension glaucoma
prevalence in sleep apnea patients with type 2
diabetes, interest of a new medical device RuSleeping© in ophthalmology. Corinne Dot, E.
Agard, H. El Chehab, I. Douma, G. Ract-Madoux,
O. C. Coste. Ophthalmology, Hopital Desgenettes,
Lyon Cedex 03, France *CR, f
3494 — D0170 Patients with advanced
glaucoma need different treatment approach.
Petja I. Vassileva, Y. Kirilova, K. Naldzhieva.
University Eye Hospital ‘’Prof. Pashev’, MUSofia’, Sofia, Bulgaria
3495 — D0171 Incidence of trabeculectomy
related complications at various Mitomycin C
Concentrations from 1985 to 2010 in Olmsted
County, MN. Jessica A. Adefusika1, C. L.
Khanna2. 1Mayo Medical School, Rochester, MN;
2
Ophthalmology, Mayo Clinic, Rochester, MN
3496 — D0172 Clinical and Demographic
features in patients with Primary Open angle
glaucoma in the Asociación Para Evitar la
Ceguera en México. Maria Garcia Ibarra, J.
Jimenez-Roman, F. Gil Carrasco. Asociación para
Evitar la Ceguera en México, México City, Mexico
3497 — D0173 Correlation between decision to
refer for glaucoma and diagnosis of glaucoma.
Preeti J. Thyparampil, B. J. Frankfort, S. D.
Orengo-Nania. Ophthalmology, Baylor College of
Medicine, Houston, TX
3498 — D0174 Impact of Patient
Comprehension on Treatment Success in
Glaucoma. Anjali Sheth1, W. A. Kirkland1, S. D.
Ronkainen1, C. N. Kirk2, S. Pillai2. 1Ophthalmology,
Washington Hospital Center/Georgetown University
Hospital, Washington, DC; 2Ophthalmology,
Georgetown University School of Medicine,
Washington, DC
3499 — D0175 Association between Myopia
and Glaucoma in a Young Adult Population.
Mary Qiu1, S. Wang1, K. Singh2, S. C. Lin1.
1
Ophthalmology, University of California San
Francisco, San Francisco, CA; 2Ophthalmology,
Stanford University, Satanford, CA *CR
3500 — D0176 Medication possession ratio and
its related factors among Japanese glaucoma
patients. Kazuyoshi Kitamura1, H. Yokomichi2,
Z. Yamagata2, K. Kashiwagi1. 1Ophthalmology,
University of Yamanashi, Chuo, Japan; 2Health
Science, University of Yamanashi, Chuo, Japan
3501 — D0177 Analysis of hematological and
biochemical data in normal tension glaucoma
patients. Morio Ueno1, Y. Ikeda1, K. Yoshii2, H.
Yoshikawa1, Y. Maruyama1, K. Mori1, K. Tashiro2, S.
Kinoshita1. 1Department of Ophthalmology, Kyoto
Prefectural University of Medicine, Kyoto, Japan;
2
Department of Genomic Medical Sciences, Kyoto
Prefectural University of Medicine, Kyoto, Japan
*CR
3502 — D0178 Prevalence of Open-angle
Glaucoma in Vitrectomized Eyes. The PR.O.V.E
Study. Andrea Govetto1, R. Domínguez Fernández1,
M. Landaluce1, M. Alves Perez2, R. Lorente1.
1
Ophthalmology, Complexo Universitario
Hospitalario de Ourense, Ourense, Spain;
2
Biostatistics, Complexo Universitario Hospitalario
de Ourense, Ourense, Spain
3503 — D0179 Correlation Between Corneal
and Optic Nerve Head Parameters. Federico
Saenz-Frances, L. Borrego, C. Berrozpe Villabona,
L. Morales-Fernandez, J. M. Martinez de la Casa,
J. Garcia-Feijoo. Glaucoma, Hospital Clínico
Universitario San Carlos, Madrid, Spain *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
236
Tuesday – Posters – 3504 – 3524
3504 — D0180 Anterior Chamber Depth and
Lens Thickness in African-Americans with
Age-Related Long Anterior Zonules. Daniel K.
Roberts1, 3, B. A. Teitelbaum1, D. D. Castells1, J.
E. Winters1, J. T. Wilensky2. 1Clinical Education,
Illinois College of Optometry, Chicago, IL;
2
Ophthalmology, University of Illinois at Chicago,
Chicago, IL; 3Epidemiology and Biostatistics,
University of Illinois at Chicago, Chicago, IL
3505 — D0181 Intraocular pressure and
central corneal thickness in an old French
population: The MONRACHET study. Alain
M. Bron1, 3, A. Francoz1, C. Fiet2, C. Binquet2,
C. Bonython-Kopp2, C. Tzourio4, N. Acar3, L.
Bretillon2, C. Creuzot-Garcher1, 3. 1Ophthalmology,
University Hospital, Dijon, France; 2Epidemiology,
University Hospital, Dijon, France; 3Eye and
Nutrition Research Group, UMR CSGA-1324
INRA-6265, CNRS-Université de BourgogneAgroSup, Dijon, France; 4Epidemiology, University
Hospital, Bordeaux, France *CR, f
3507 — D0183 What do patients know
about glaucoma? Effects of education at 1
and 6 months after the program. Fabian S
Lerner1, 2, J. I. Yankelevich3. 1Fundacion para el
Estudio del Glaucoma, Buenos Aires, Argentina;
2
Postgraduate Department, University Favaloro
School of Medicine, Buenos Aires, Argentina;
3
Ophthalmology, University of Buenos Aires,
Buenos Aires, Argentina
3508 — D0184 Variability of trabeculectomy
among glaucoma surgeons: a survey from
different countries. Glauco B. Almeida1, C.
Zangalli2, L. M. Alencar1, M. Hatanaka1, E. L.
Ferreira3, G. L. Spaeth2. 1Glaucoma, Universidade
de São Paulo, Campo Grande, Brazil; 2Glaucoma,
Wills Eye Institute, Philadelphia, PA; 3Glaucoma,
Hospital Santa Casa, Campo Grande, Brazil *CR
3509 — D0185 The Estimated Impact of
Changing Refractive Errors on the Future Rates
of Angle-closure and Open Angle Glaucoma in
Asia. Naomi V. Odell, M. A. Slabaugh, L. Ding.
Ophthalmology, University of Washington, Seattle,
WA
3510 — D0186 The Relationship of Body
Mass Index (BMI) to Glaucoma. Jessica Prince,
N. Geberer, W. Yao, B. Katz. Ophthalmology,
Montefiore Med Ctr/Albert Einstein, New York, NY
3517 — D0193 Impact of Educational
Intervention on Compliance with Topical
Therapy for Glaucoma. Shani Reich1, J. E. Rome1,
J. Manns1, L. Droll1, J. Zelefsky1, 2. 1Department of
Ophthalmology, Bronx Lebanon Hospital, Bronx,
NY; 2Department of Ophthalmology and Visual
Sciences, Albert Einstein College of Medicine,
Bronx, NY *CR
3512 — D0188 Longitudinal analysis of
age related changes in intraocular pressure
in South Koreans. SungUk Baek1, C. Kee2, W.
Suh1. 1Ophthalmology, Hallym University Sacred
Heart Hospital, Anyang-city, Republic of Korea;
2
Ophthalmology, Samsung Medical Center,
Sungkyunkwan University School of Medicine,
Seoul, Republic of Korea
3518 — D0194 First-degree Consanguinity as
a risk factor to developing primary open-angle
Glaucoma in Mexican families. Elia Chavez1, J. A.
Paczka1, A. Soto-Gomez2, M. A. Ramos-Hernandez1.
1
Oftalmologia, Instituto de Oftalmologia y Ciencias
Visuales. Universidad de Guadalajara, Guadalajara,
Mexico; 2Oftalmologia, CE + CECIS ISSSTE,
Guadalajara, Mexico
3513 — D0189 Evaluation of Ocular Surface
Disease in Patients with Glaucoma. Priya M.
Mathews, P. Y. Ramulu, D. S. Friedman, E. K.
Akpek. Wilmer Eye Institute, Johns Hopkins
University, Baltimore, MD *CR
3519 — D0195 Associations between
Systemic Factors and Longitudinal Analyses
of Intraocular Pressure: Mean, Peak and
Variability. Thasarat S. Vajaranant1, C. E. Joslin1, 2.
1
Ophthalmology and Visual Sciences, University
of Illinois at Chicago, Chicago, IL; 2Division of
Epidemiology and Biostatistics, School of Public
Health, University of Illinois at Chicago, Chicago,
IL
3514 — D0190 Reduced social participation
among seniors with non refractive vision
problems and glaucoma. Yaping Jin1, 2, E.
Badley2, 3, M. Gignac3, 2, Y. M. Buys1, K. Thavorn4,
G. E. Trope1. 1Ophthalmology & Vis Sci, University
of Toronto, Toronto, ON, Canada; 2Dalla Lana
School of Public Health, University of Toronto,
Toronto, ON, Canada; 3Division of Health Care &
Outcomes Research, University Health Network,
Toronto, ON, Canada; 4Applied Health Research
Centre, St. Michael’s Hospital, Toronto, ON,
Canada *CR
3515 — D0191 Using a Structural Equation
Measurement Model (SEMM) for Nested
Data to Describe Agreement among Lamina
Cribrosa Pore Segmentation Methods.
Richard A. Bilonick1, 2, B. Wang1, 3, Z. Nadler1,
G. Wollstein1, H. Ishikawa1, 4, Y. Ling1, 2, L.
Kagemann1, 4, J. S. Schuman1, 4. 1UPMC Eye Center,
Eye & Ear Institute, Ophthalmology and Visual
Science Research Center, Dept. Ophthalmology,
U.Pittsburgh School of Medicine, Pittsburgh, PA;
2
Dept. Biostatistics, U. Pittsburgh Graduate School
of Public Health, Pittsburgh, PA; 3Medical Scientist
Training Program, University of Pittsburgh,
Pittsburgh, PA; 4Dept. Bioengineering, Swanson
School of Engineering, U. Pittsburgh, Pittsburgh,
PA *CR
3516 — D0192 Bridging the Major Clinical
Trials and Everyday Clinical Practice: Central
Corneal Thickness and Visual Field Damage are
Independent Risk Factors for Progression in a
6-Year Retrospective Evaluation Of Patients’
Electronic Chart Records. Stefano A. Gandolfi1,
D. Paoli2. 1Ophthalmology, University of Parma,
Parma, Italy; 2Ophthalmology, Community
Hospital, Monfalcone, Italy *CR
3520 — D0196 Comparison of the sensitivity
and specificity of the Von Herick test and ocular
biometric parameters as screening tests in
prevalent and incident angle closure disease in
a population based study. Ronnie J. George, R.
Dinesh, M. Panday, R. S Ve, V. Lingam. Glaucoma,
Sankara Nethralaya Eye Hospital, Chennai, India
3521 — D0197 Glaucoma Awareness in
Relatives of Patients Diagnosed with Glaucoma.
Aaron Smith1, J. Oakley2, S. T. Hoadley1, E. J.
Smith1, O. O. Idowu1. 1Univeristy of Mississippi
Medical Center, Jackson, MS; 2University of South
Florida, Tampa, FL
3522 — D0198 The Glaucoma Treatment
Compliance Assessment Tool (GTCAT) has an
organizational structure consistent with the
Health Belief Model. Gordon Barker1, P. F. Cook2,
M. Y. Kahook2, J. Kammer3, S. L. Mansberger1.
1
Devers Eye Institute, Portland, OR; 2University
of Colorado, Aurora, CO; 3Vanderbilt University,
Nashville, TN *CR
3523 — D0199 Glaucoma in Patients After
Iodine-125 Brachytherapy for Uveal Melanoma.
Crystal Hung, T. McCannel, S. K. Law, J. A.
Giaconi. Jules Stein Eye Institute/UCLA, Los
Angeles, CA *CR
3524 — D0200 Relationship between eye shape
and the risk for glaucoma. Divakar Gupta1,
D. B. Moore2, K. D. Bojikian1, M. A. Slabaugh1.
1
Ophthalmology, University of Washington, Seattle,
WA; 2Ophthalmology, Duke Eye Center, Durham,
NC
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
237
Tuesday Posters
11:00 am – 12:45 pm
3506 — D0182 The Ocular Hypertension
Treatment Study (OHTS): Does Higher
Long-Term IOP Variability Increase Risk Of
Developing Primary Open Angle Glaucoma
(POAG) in the Medication Group? Mae O.
Gordon1, 2, J. A. Beiser1, J. Miller2, M. A. Kass1,
F. Gao2. 1Ophthal & Vis Sciences, Washington
Univ Sch of Med, St Louis, MO; 2Division of
Biostatistics, Washington Univ Sch of Med, St
Louis, MO f
3511 — D0187 Eyes with Large Optic Disc
Cupping and Normal Intraocular Pressure:
Clinical and Epidemiological Differences
Between Those with and Without Glaucoma.
Tiago S. Prata1, 2, M. C. Sousa1, M. T. Leite1, A.
Paranhos1. 1Ophthalmology, Federal University of
Sao Paulo, Sao Paulo, Brazil; 2Hospital Medicina
dos Olhos - HMO, Osasco, Brazil *CR
3525 – 3546 – Tuesday – Posters
3525 — D0201 Latent Growth Curve Model
for Calibration between Measurements
Obtained by Multiple Devices. Yun Ling1, 2, R.
A. Bilonick1, 2, I. I. Bussel1, 3, H. Ishikawa1, 4, G.
Wollstein1, L. Kagemann1, 4, I. A. Sigal1, 4, J. S.
Schuman1, 4. 1UPMC Eye Center, Eye and Ear
Institute, Ophthalmology and Visual Science
Research Center, Dept. of Ophthalmology, U.
Pittsburgh School of Medicine, Pittsburgh, PA;
2
Dept. Biostatistics, U. PIttsburgh Granduate
School of Public Health, Pittsburgh, PA; 3RFUMS/
Chicago Medical School, Chicago, IL; 4Dept.
Bioengineering, Swanson School of Engineering, U.
PIttsburgh, Pittsburgh, PA *CR
3531 — D0260 Transforming Growth
Factor-β2 (TGF-β2) Induces Expression of
Biologically Active Bone Morphogenetic
Protein-1 (BMP1) in Human Trabecular
Meshwork Cells. Tara Tovar-Vidales1, 2, A. M.
Fitzgerald1, 2, A. F. Clark1, 2, R. J. Wordinger1, 2. 1Cell
Biology & Anatomy, University of North Texas
Hlth Sci Ctr, Fort Worth, TX; 2North Texas Eye
Research Institute, University of North Texas Hlth
Sci Ctr, Fort Worth, TX *CR
Exhibit Hall D0255-D0296
3533 — D0262 Proteomic Analysis of
Trabecular Meshwork Extracellular Matrix.
Vasanth Rao1, R. Maddala2, N. P. Skiba2.
1
Ophthalmology & Pharmacology, Duke University
Medical Center, Durham, NC; 2Ophthalmology,
Duke University Medical Center, Durham, NC
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Glaucoma
347 Trabecular Meshwork II
Tuesday Posters
11:00 am – 12:45 pm
Moderators: Michael P. Fautsch and
Robert J. Wordinger
3526 — D0255 Aging of Schlemm’s canal in
primary open angle glaucoma in hereditary
and non-hereditary cases. Teruhiko Hamanaka1,
T. Sakurai2, A. Matsuda3, A. Murakami3.
1
Ophthalmology, Japanese Red Cross Medical Ctr,
Shibuya-Ku, Japan; 2Center of General Education,
Tokyo University of Science, Suwa, Suwa, Japan;
3
Ophthalmology, Juntendo University, Tokyo, Japan
*CR
3527 — D0256 A magnetic bead-based method
for mouse trabecular meshwork cell isolation.
Weiming Mao, Y. Liu, R. J. Wordinger, A. F. Clark.
Cell Biology & Anatomy, UNT Health Science
Center, NTERI, Fort Worth, TX *CR
3528 — D0257 Live Imaging of Actin Structure
in Human Trabecular Meshwork. Jeremy
Hwang, J. M. Gonzalez, J. C. Tan. Ophthalmology,
University of Southern California, Los Angeles, CA
3529 — D0258 Dynamic Re-establishment
of the Actin Cytoskeleton Impacts the
Mechanotranducing Pathway in Human
Trabecular Meshwork Cells. Paul Russell1, S. M.
Thomasy1, C. J. Murphy1, 2. 1Department of Surgical
and Radiological Sciences, University of California
Davis, Davis, CA; 2Department of Ophthalmology
and Vision Science, University of California, Davis,
Davis, CA *CR
3530 — D0259 Imaging the Effects of
Prostaglandins on Cultured Trabecular
Meshwork Cells by Coherent Anti-Stokes
Raman Scattering (CARS). David A. Ammar1,
O. Masihzadeh1, M. Y. Kahook1, T. C. Lei2.
1
Ophthalmology, Univ of Colorado Denver School
of Medicine, Aurora, CO; 2Electrical Engineering,
Univ of Colorado Denver, Denver, CO *CR
3532 — D0261 Dexamethasone induces stress
fiber re-arrangement through non-canonical
Wnt signaling in trabecular meshwork cells.
Yong Yuan, C. Liu, W. W. Kao. Ophthalmology,
University of Cincinnati, Cincinnati, OH
3534 — D0263 Microspheres (MS) Perfused
into the Anterior Chamber (AC) enter the
Lumen of Cylindrical Structures Spanning
Schlemm’s canal (SC). Elizabeth Martin1, 2, N.
Orkney2, M. A. Johnstone2. 1Univ of Washington
Sch of Med, Seattle, WA; 2Ophthalmology,
University of Washington, Seattle, WA *CR
3535 — D0264 Benzalkonium Chloride is
Cytotoxic While Preservative-free Tafluprost is
Cytoprotective in Human Trabecular Meshwork
Cells. Caitlin A. Chang1, C. M. Hutnik2. 1Faculty
of Medicine and Dentistry, University of Western
Ontario, London, ON, Canada; 2Ophthalmology,
Ivey Eye Institute, London, ON, Canada
3536 — D0265 Expression of Stem Cell
Markers in the Bovine Corneal Endothelium,
Insert Region and Trabecular Meshwork.
Wing Yan Yu1, C. M. Sheridan2, I. Grierson2, A. C.
Lo1, 3, S. Wong1, 3. 1Department of Ophthalmology,
The University of Hong Kong, Pokfulam, Hong
Kong; 2Department of Eye and Vision Science,
The University of Liverpool, Liverpool, United
Kingdom; 3Research Centre of Heart, Brain,
Hormone and Healthy Aging, The University of
Hong Kong, Pokfulam, Hong Kong *CR
3537 — D0266 Metabolic Dependence of
Conventional Outflow Facility in Mice. Alexandra
Boussommier Calleja1, W. Stamer3, C. R. Ethier1, 2,
D. R. Overby1. 1Bioengineering, Imperial College
London, London, United Kingdom; 2Biomedical
engineering, Georgia Institute of Technology,
Atlanta, GA; 3Ophthalmology, Duke University,
Durham, NC *CR
3538 — D0267 Schlemm’s Canal (SC) Inner
Wall Pores Correlate with Segmental Outflow in
Human Eyes. C R. Ethier1, 2, S. T. Braakman2, A.
T. Read3, D. W. Chan3, D. R. Overby2. 1Biomedical
Engineering, Georgia Institute of Technology,
Atlanta, GA; 2Bioengineering, Imperial College,
London, United Kingdom; 3Ophthalmology and
Vision Science, University of Toronto, Toronto, ON,
Canada *CR
3539 — D0268 Transcriptional Profiling
of Human Schlemm’s Canal Cells Following
Latanoprost, Bimatoprost and Prostaglandin
F2alpha (PGF2α) Treatment. Nelson S. Winkler1,
U. Roy Chowdhury2, M. P. Fautsch2. 1Mayo Medical
School, Rochester, MN; 2Ophtahlmology, Mayo
Clinic, Rochester, MN
3540 — D0269 Microparticle Delivery of
Matrix Metalloproteinase-3 to Trabecular
Meshwork Cells. Beatrice Yue1, S. B. Turturro1,
S. Sunoqrot2, H. Ying1, S. Hong2. 1Ophthal & Vis
Sciences, Univ of Illinois at Chicago, Chicago, IL;
2
Departments of Biopharmaceutical Sciences and
Bioengineering, University of Illinois at Chicago,
Chicago, IL
3541 — D0270 Clinical Efficacy of Ultrasonic
Circular Cyclo Coagulation in Refractory
Glaucoma. Preliminary Results. Paolo
Fogagnolo1, M. Digiuni2, E. Maggiolo2, L. M.
Rossetti2. 1Fondazione GB Bietti-IRCCS, Rome,
Italy; 2University Eye Clinic, San Paolo Hospital,
Milan, Italy f
3542 — D0271 Effect Oof Cellular and Plasma
Fibronectin Isoforms on Normal Human
Trabecular Meshwork Cells. Wanda E. MedinaOrtiz1, 2, R. J. Wordinger1, 2, A. F. Clark1, 2. 1Cell
Biology and Anatomy, Univ of North Texas Hlth
Science Ctr, Fort Worth, TX; 2NTERI, Univ of
North Texas Hlth Science Ctr, Fort Worth, TX *CR
3543 — D0272 Decrease of nuclear Yesassociated protein (YAP) with human trabecular
meshwork (HTM) cell passage. Joshua Morgan1,
C. J. Murphy1, 2, P. Russell1. 1Veterinary Medicine:
Surgical and Radiological Sciences, University of
California, Davis, Davis, CA; 2School of Medicine:
Department of Ophthalmology and Vision Sciences,
University of California, Davis, Davis, CA *CR
3544 — D0273 Three-dimensional structure
of the mouse ciliary muscle, its innervation and
connections to the outflow tissues and choroid.
Elke Luetjen-Drecoll1, O. Tektas1, D. R. Overby2.
1
Dept. of Anatomy II, University of Erlangen
Nurnberg, Erlangen, Germany; 2Bioengineering,
Imperial College London, london, United Kingdom
*CR
3545 — D0274 Prdx6 abates the process of
senescence and restores trabecular meshwork
cell integrity by regulating Telomerase, p16
and p21 Expression. Nigar Fatma1, E. Kubo2,
B. Chhunchha1, W. Stamer3, D. P. Singh1.
1
Ophthalmology and Visual Sciences, Univ of
Neb Med Center, Omaha, NE; 2Ophthalmology,
Kanazawa Medical University, Kanazawa,
Japan; 3Ophthalmology, Duke Eye Center, Duke
University, Durham, NC *CR
3546 — D0275 ADAMTS4 activity and
TIMP3 levels are modulated in trabecular
meshwork cells with decreased hyaluronan
synthesis. Kate E. Keller, Y. Yang, Y. Sun, T. S.
Acott. Ophthalmology, Casey Eye Insitute - OHSU,
Portland, OR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
238
Tuesday – Posters – 3547 – 3570
3547 — D0276 Mechanical Stress Activates
Autophagy in Trabecular Meshwork Cells.
Ping Xu, K. M. Porter, N. Jeyabalan, P. B. Liton.
ophthamology, Duke University, Durham, NC
3548 — D0277 Diminished Autophagic
Capacity of Glaucomatous Trabecular
Meshwork Cells. Kristine M. Porter, P. Xu, W.
Stamer, P. B. Liton. Ophthalmology-DUMC 3802,
Duke Eye Center, Durham, NC *CR
3549 — D0278 Overexpression of SPARC
Upregulates Gremlin and Proteoglycans Opticin
& Decorin. Swarup S. Swaminathan, D. Oh, D. J.
Rhee. Dept. of Ophthalmology, Massachusetts Eye
& Ear Infirmary, Boston, MA *CR
3550 — D0279 Multimodal Microscopy of
Aqueous Drainage Channels in Live Mice. Jose
M. Gonzalez, J. C. Tan. Ophthalmology, University
of Southern California, Los Angeles, CA
3551 — D0280 Transcriptional Co-regulatory
Patterns Associated with TNFα Treatment of
Trabecular Meshwork Cells. Lauren Hayashi1,
D. Choi2, K. Carr2, M. J. Kelley1, T. S. Acott1.
1
Ophthalmology, Casey Eye Institutue, Oregon
Health and Science University, Portland, OR;
2
Public Health and Preventitive Medicine, Oregon
Health and Science University, Portland, OR
3553 — D0282 In situ 3D Distribution of
Filamentous Actin in Mouse Trabecular
Meshwork. James C. Tan, J. M. Gonzalez, M. K.
Ko. Ophthalmology, Univ of Southern California,
Los Angeles, CA
3554 — D0283 Effects of Calcitonin Gene
Related Peptide on Bovine Trabecular Meshwork
and Ciliary Muscle. Dai Ogino, S. Watanabe, Y.
Ohta, K. Fujiwara, T. Yoshitomi. Department of
Ophthalmology, Akita University, Akita-shi, Japan
*CR
3555 — D0284 Stem Cells from Trabecular
Meshwork Home to Damaged TM Tissue in
vivo. Yiqin Du, H. Yun, E. Yang, J. S. Schuman.
Ophthalmology, University of Pittsburgh,
Pittsburgh, PA *CR
3556 — D0285 Identification of TGF-β2induced Proinflammatory Cytokines Secreted
from Cultured Trabecular Meshwork
Cells. Miyuki Inoue, T. Inoue, T. Fujimoto, N.
Awai-Kasaoka, H. Tanihara. Department of
Ophthalmology, Kumamoto University, Faculty of
Life Sciences, Kumamoto, Japan
3559 — D0288 Cuantitative study of the
trabecular meshwork and its relationship to
the morphometry of the eye in the normal
population using an anterior segment Fourier
Domain OCT. José Fernández-Vigo López1, J.
Fernández-Vigo2, C. Fernandez-Vigo Escribano3,
J. M. Martinez de la Casa2, J. Garcia-Feijoo2.
1
Ophthalmology, Cioa - Universidad de
Extremadura, Madrid, Spain; 2Ophthalmology,
Hospital Clinico San Carlos, Madrid, Spain; 3Centro
de Oftalmologia Barraquer, Barcelona, Spain *CR
3560 — D0289 Caveolins modulate ECM
turnover by Trabecular Meshwork cells. Mini
Aga, K. E. Keller, J. M. Bradley, T. S. Acott.
Ophthalmology, Casey Eye Institute, Oregon Health
& Science University, Portland, OR
3561 — D0290 Artificial Simulation of
Conventional Aqueous Humor Outflow
Dynamics. Eun Kyoung Kim, E. R. Chu, A.
Yelenskiy, J. M. Gonzalez, J. C. Tan. Department of
Ophthalmology, Doheny Eye Institute, Keck School
of Medicine, University of Southern California, Los
Angeles, CA *CR
3562 — D0291 Trabecular Meshwork Cell
Expression of Two Novel Mucin Genes Located
in the MHC Class I Locus. M. Elizabeth Fini, S.
Jeong. USC Institute for Genetic Medicine, Keck
School of Medicine of USC, Los Angeles, CA
3563 — D0292 Effect of NaHS, a fast-releasing
Hydrogen sulfide donor on Aqueous Humor
Outflow in Porcine Trabecular Meshwork. Ya
Fatou Njie-Mbye1, J. Robinson1, A. Okpobiri1, M.
Chitnis1, C. A. Opere2, S. E. Ohia1. 1Pharmaceutical
Sciences, TX Sthrn Univ-Coll of Pharm & Hlth Sci,
Houston, TX; 2Department of Pharmacy Sciences,
Creighton University, Omaha, NE
3564 — D0293 Zonular Ligament Dysplasia
in Beagles with Hereditary Primary Open
Angle Glaucoma (POAG). Leandro B. Teixeira1,
E. M. Scott1, S. Iwabe3, R. R. Dubielzig1, A. M.
Komaromy2, 3. 1Pathobiological Science, UWMadison Sch of Vet Med, Madison, WI; 2College
of Veterinary Medicine, Michigan State University,
East Lansing, MI; 3School of Veterinary Medicine,
University of Pennsylvania, Philadelphia, PA *CR
3557 — D0286 Type I collagen-induced
Epithelial Mesenchymal Transition-like
Phenomenon in Trabecular Meshwork Cells.
Ayako Fukushima, E. Takahashi, T. Fujimoto, S.
Kojima, T. Inoue, H. Tanihara. Ophthalmology,
Kumamoto University, Kumamoto, Japan
3565 — D0294 Overexpression of GPR158, an
Orphan Member of G Protein-Coupled Receptor
Family C, Mimics Effects of Glucocorticoids on
Trabecular Meshwork Cells. Nitin L. Patel1, T.
Itakura1, M. Fini1, 2. 1Institute for Genetic Medicine,
Keck School of Medicine of USC, Los Angeles,
CA; 2Cell & Neurobiology, Keck School of
Medicine of USC, Los Angeles, CA
3566 — D0295 Extracellular Matrix Gene
Expression Profiling of High and Low Flow
Areas of Human Trabecular Meshwork. Janice
A. Vranka, K. E. Keller, T. S. Acott. Ophthalmology,
Casey Eye Inst/Oregon Hlth & Sci Univ, Portland,
OR
3567 — D0296 Oxidative Stress Impacts On
Barrier Function of Porcine Angular Aqueous
Plexus Cell Monolayers. Yuan Lei1, W. Stamer2,
J. Wu1, X. Sun3. 1Research Centre, Eye and ENT
hospital, Shanghai, China; 2Ophthalmology, Duke
University, Durham, NC; 3Ophthalmology, Eye and
ENT hospital, Shanghai, China *CR
Exhibit Hall D0297-D0319
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Multidisciplinary Ophthalmic Imaging
348 Anterior Segment Imaging
Moderators: Joseph A. Izatt and Jianhua Wang
3568 — D0297 Tear meniscus volume changes
in external dacryocystorhinostomy (ex-DCR)
evaluated with quantitative measurement using
anterior segment optical coherence tomography
(AS-OCT). Kazuyoshi Ohtomo1, T. Miyai1, R.
Fukuda1, 2, T. Usui1, R. Shirakawa1, T. Ueta1, S.
Amano1, M. Nagahara1. 1Ophthalmology, The
University of Tokyo hospital, Tokyo, Japan;
2
Ophthalmology, Teishin hospital, Tokyo, Japan
*CR
3569 — D0298 Inter- and Intra-Observer
Agreement and Repeatability of Imaging
the Meibomian Glands with the OCULUS
Keratograph 4 and Keratograph 5M. William
Ngo, S. Srinivasan, M. Schulze, L. W. Jones. Centre
for Contact Lens Research, School of Optometry
and Vision Science, University of Waterloo,
Waterloo, ON, Canada *CR
3570 — D0299 Ocular coherence tomography
(OCT) guided adjustment of Prosthetic
Replacement of the Ocular Surface Ecosystem
(PROSE) device fit can treat device induced
corneal edema. Kristin O. Chapman, A. G. Alzaga
Fernandez, M. N. Lee, K. C. Sippel, P. Sood, R.
M. St Clair, C. E. Starr, J. Ciralsky, M. Rosenblatt.
Ophthalmology, Weill Cornell Medical Center, New
York, NY
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
239
Tuesday Posters
11:00 am – 12:45 pm
3552 — D0281 Characterization of
Sirtuin family protein expression in human
trabecular meshwork cells. Ayan Chatterjee,
S. S. Oh, G. Villarreal, D. J. Rhee. Department
of Ophthalmology, Massachusetts Eye and Ear
Infirmary, Cambridge, MA *CR
3558 — D0287 Smad3 phosphorylation
promotes Transforming Growth Factor-β2
mediated expression of endothelin-1 in human
trabecular meshwork cells. Cynthia L. Von
Zee1, 2, J. D. Lautz1, 3, K. Langert1, 2, E. B. Stubbs1, 2.
1
Research Service (151), Loyola University Medical
Center, Maywood, IL; 2Ophthalmology, Loyola
University Chicago Stritch School of Medicine,
Maywood, IL; 3Program in Neuroscience, Loyola
University Chicago Stritch School of Medicine,
Maywood, IL
3571 – 3590 – Tuesday – Posters
3571 — D0300 Ultrasonic Biomicroscopy as a
complementary tool for the evaluation of diseases
of the lacrimal drainage system. Sara I. Plazola,
M. Flores, A. Guzman. Orbit and Oculoplastics,
Centro Medico Nacional 20 de Noviembre Issste,
Mexico, Mexico
3572 — D0301 An Anterior Chamber Optical
Tissue Phantom for AC-OCT. Temple S. Rowe.
Rowe Technical Design Inc, Dana Point, CA *CR
3573 — D0302 360 Degree In-Vivo Imaging
of the Human Limbus by Optical Coherence
Tomography. Kira L. Lathrop1, 2, H. Ishikawa1, 2,
L. Kagemann1, 2, J. S. Schuman1, 2. 1Ophthalmology,
University of Pittsburgh, Pittsburgh, PA;
2
Bioengineering, University of Pittsburgh,
Pittsburgh, PA *CR
Tuesday Posters
11:00 am – 12:45 pm
3574 — D0303 In vivo live-cell imaging of
human trabecular meshwork cells under laminar
flow. Akhilesh Kumar, X. Chen, M. Conwell,
N. Luo, A. G. Obukhov, Y. Sun. Department of
Ophthalmology, Indiana University, Indianapolis,
IN *CR
3575 — D0304 Architecture for Angle Closure
Glaucoma: Novel methods for Imaging, Risk
Assessment and Screening (AGAR). Jimmy Jiang
Liu1, Y. Xu1, B. Lee1, M. Htoo1, D. Wong1, B. Mani2,
T. Aung2, T. Y. Wong2. 1Insittute for Infocomm
Research, Singapore, Singapore; 2Singapore Eye
Research Insttute, Singapore, Singapore *CR
3576 — D0305 Comparative Study of the
Nidek Specular Microscope CEM-530 and
the CELLCHEK XL Predicate Device for the
Measurements of Endothelial Cell Density
Measurements, Coefficient of Variation of
Endothelial Cell Area, and percent Hexagonality.
Ron Kaiser1, R. Bouchard2, A. Shapiro2, G. L.
Torkildsen3, J. B. Ciolino4, T. Murata1. 1Nidek
Co, Inc, Fremont, CA; 2Ora, Inc., Andover,
MA; 3Andover Eye Associates, Andover, MA;
4
Massachusetts Eye and Ear Infirmary, Boston, MA
*CR, f
3577 — D0306 Confocal Microscopy of
Corneal Nerves for Early Detection of Diabetic
Neuropathy in Recently Diagnosed Type 2
Diabetic Patients. Andrey Zhivov1, D. Ziegler2, 3,
S. Peschel1, S. Allgeier4, K. Winter5, B. Koehler4,
N. Papanas2, O. Stachs1, M. Roden2, 3, R. F.
Guthoff1. 1Ophthalmology Department, University
of Rostock, Rostock, Germany; 2Institute for
Clinical Diabetology, German Diabetes Center at
Heinrich Heine University, Düsseldorf, Germany;
3
Department of Metabolic Diseases, University
Hospital, Heinrich Heine University, Düsseldorf,
Germany; 4Institute for Applied Computer Science,
Karlsruhe Institute of Technology (KIT), Karlsruhe,
Germany; 5Translational Centre for Regenerative
Medicine (TRM), University of Leipzig, Leipzig,
Germany *CR
3578 — D0307 Diabetic Foot Syndrome and
Changes of Corneal Subbasal Nerve Plexus
in Diabetes Type 2 Congolese Patients. Sabine
Peschel1, A. Zhivov1, H. Schober2, O. Stachs1,
M. N. Bambi3, N. J. Kilangalanga3, K. Winter4,
R. F. Guthoff1. 1Department of Ophthalmology,
University of Rostock, Rostock, Germany; 2Klinik
für Innere Medizin I, Klinikum Südstadt, Rostock,
Germany; 3Department of Ophthalmology, Saint
Joseph Hospital, Kinshasa, The Democratic
Republic of the Congo; 4Translational Centre for
Regenerative Medicine (TRM), University of
Leipzig, Leipzig, Germany
3579 — D0308 Anterior Segment Fluorescein
Angiography Findings in Patients with Fuchs’
Heterochromic Iridocyclitis compared with
Normal Subjects. Cyntia Solis, S. Voorduin, F.
Martinez, T. Valdez. Fundación Hospital Nuestra
Señora de la Luz, Mexico
3580 — D0309 Real-time anterior segment
biometry and its relation to accommodative
response. Dexi Zhu1, M. Shen1, L. Leng1, Y. Shao1, 2,
J. Wang1, 2, F. Lu1. 1Wenzhou Medical College,
Wenzhou, China; 2Bascom Palmer Eye Institute,
University of Miami, Miami, FL *CR
3581 — D0310 Repeatability of Crystalline
Lens Thickness Measurements in the
Accommodating Eye. Lesley A. Doyle, J. Little,
K. J. Saunders. School of Biomedical Sciences,
University of Ulster, Coleraine, United Kingdom
3582 — D0311 Automatic biometry of human
anterior segment during accommodation.
Meixiao Shen1, D. Zhu1, Y. Shao1, L. Leng1, J.
Wang2, F. Lu1. 1School of Ophthalmology &
Optometry, Wenzhou Medical College, Wenzhou,
China; 2Department of Ophthalmology, Bascom
Palmer Eye Institute, University of Miami, Miami,
FL *CR
3583 — D0312 Corneal Alkali Burn Induces
Inflammatory Changes In The Central
Nervous System. Fabio Bignami1, G. Ferrari1,
C. Giacomini1, E. Capitolo2, L. Chaabane2, P.
Rama1. 1Cornea Unit - Eye Repair Lab, San
Raffaele Scientific Institute, Milan, Italy; 2Institute
of Experimental Neurology (INSpe), Division of
Neuroscience, San Raffaele Scientific Institute,
Milan, Italy
3584 — D0313 A Novel Telemedicine Device
for Diagnosis of Corneal Abrasions and Ulcers
in Resource-Poor Settings. Robi N. Maamari1, 2,
S. Ausayakhun3, T. P. Margolis1, 4, T. M. Lietman1,
4
, D. A. Fletcher5, J. D. Keenan1, 4. 1Department
of Ophthalmology, University of California,
San Francisco, San Francisco, CA; 2School of
Medicine, University of California, Irvine, Irvine,
CA; 3Department of Ophthalmology, Chiang Mai
University, Chiang Mai, Thailand; 4F. I. Proctor
Foundation, San Francisco, CA; 5Department of
Bioengineering, University of California, Berkeley,
Berkeley, CA *CR
3585 — D0314 Hyperglycemia-induced corneal
abnormalities in diabetic rats and humans.
Laura Kowalczuk1, 2, G. Latour4, J. Bourges3, M.
Savoldelli3, J. P. Jeanny1, 2, M. Schanne-Klein4, F.
F. Behar-Cohen1, 3. 1Physiopathology of Ocular
Diseases, INSERM UMRS 872, Paris, France;
2
Centre de Recherches des Cordeliers, Pierre et
Marie Curie University, Paris Descartes University,
Paris, France; 3AP-HP Hôtel-Dieu Hospital,
Department of ophthalmology, Sorbonne Paris
Cité, Paris Descartes university, Paris, France;
4
Laboratory for Optics and Biosciences, École
Polytechnique - CNRS - INSERM U696, Paris,
France *CR
3586 — D0315 Real-time intraoperative
assessment of the cornea with microscope
integrated optical coherence tomography. Justin
V. Migacz1, A. N. Kuo2, A. M. Dubis2, O. CarrascoZevallos1, C. A. Toth2, J. A. Izatt1. 1Biomedical
Engineering, Duke University, Durham, NC;
2
Ophthamology, Duke Eye Center, Durham, NC
*CR
3587 — D0316 Intraoperative Optical
Coherence Tomography in Deep Anterior
Lamellar Keratectomy. John Au, W. J. Dupps, J.
Goshe, J. P. Ehlers, G. M. Smith. Cole Eye Institute,
Cleveland Clinic, Cleveland, OH *CR
3588 — D0317 Fluorescence multi-laser
scanning microscopy of the cornea and ocular
adnexa: a new era for functional confocal
microscopy in ophthalmology. Gilles Thuret2, 1,
M. Espinasse2, 1, D. Grivet1, Z. He2, N. Campolmi2, 1,
J. Perrot3, E. Cinotti3, F. Forest4, 2, M. Peoc’h4, 2,
P. Gain2, 1. 1Ophthalmology, University Hospital
of St-Etienne, Saint-Etienne, France; 2Laboratory
“Biology, engineering and imaging of Corneal
Graft” EA2521, Faculty of Medicine, University
Jean Monnet, Saint-Etienne, France; 3Dermatology,
University Hospital of Saint-Etienne, Saint-Etienne,
France; 4Pathology, University Hospital of SaintEtienne, Saint-Etienne, France
3589 — D0318 Analysis of Anterior Chamber
Inflammation by Spectral Domain Optical
Coherence Tomography. Sumit Sharma, K.
Baynes, P. K. Kaiser, C. Y. Lowder, S. K. Srivastava.
Cole Eye Institute, Cleveland Clinic, Cleveland,
OH *CR
3590 — D0319 Ultrabiomicroscopy in patients
with uveitis and it’s correlation with clinical
findings. Stephanie Voorduin, A. A. Mendoza, D.
Salas, M. M. Maldonado, F. Martinez, T. Valdez.
Enfermedades Inflamatorias Oculares, Fundación
Hospital Nuestra Señora de la Luz, Mexico
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
240
Tuesday – Posters – 3591 – 3607
Exhibit Hall D0320-D0367
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Multidisciplinary Ophthalmic Imaging
349 Vitreoretinal Imaging
Moderator: Srinivas R. Sadda
3591 — D0320 Utility of Infrared Imaging
For Visualizing Persistent Subretinal Fluid
After Retinal Detachment Surgery. Do Gyun
Kim1, 2, D. P. Han1, D. V. Weinberg1, J. E. Kim1.
1
Ophthalmology, Eye institute, Medical College
of Wisconsin, Milwaukee, WI; 2Ophthalmology,
Myongji Hospital, Medical College, Kwandong
university, Go-yang, Republic of Korea *CR
3592 — D0321 Fundus Autofluorescence
Findings and Ancillary Imaging in MEWDS
Patients without White Dots. Anthony Joseph1, E.
Rahimy1, K. Freund2, 3, D. Sarraf1. 1Ophthalmology,
Jules Stein Eye Institute - UCLA, Los Angeles,
CA; 2Vitreous Retina Macula Consultants of New
York, New York, NY; 3Ophthalmology, New York
University School of Medicine, New York, NY *CR
3594 — D0323 Optos fundus imaging in
patients with keratoprosthesis. William D. Terrell,
A. Tarabishy, A. Hendershot, R. Kuennen, T.
Mauger, C. M. Cebulla. Ophthalmology and Visual
Science, Ohio State University, Columbus, OH
3595 — D0324 Multimodality Imaging Of
Retinal Astrocytic Hamartoma. Lucía De
Pablo1, 3, E. Semenova1, 2, P. T. Finger1, 2. 1The New
York Eye Cancer Center, New York, NY; 2The New
York Eye and Ear Infirmary, New York, NY; 312 de
Octubre Hospital, Madrid, Spain *CR
3596 — D0325 Optical coherence tomography
and ultra-wide-field autofluorescence imaging
are the useful tools to understand the changes
in peripheral retinal lesions. Azusa Fujikawa,
K. Suzuma, K. Yamada, D. Inoue, T. Kitaoka.
Ophthalmology and Visual Sciences, Nagasaki
University, Nagasaki, Japan
3597 — D0326 A comparison of spectral
domain optical coherence tomography and
multifocal electroretinography findings in
hydroxychloroquine retinopathy. Mark E.
Seamone1, K. Milton3, M. C. Deschenes3, M.
Fielden1, A. Kherani2, 3, R. Williams2, 3. 1Medicine,
University of Calgary, Calgary, AB, Canada;
2
Surgery, University of Calgary, Calgary, AB,
Canada; 3Calgary Retina Consultants, Calgary, AB,
Canada *CR
3599 — D0328 “En face” OCT for retreatment
indications during follow up of Vascularized
Pigment Epithelium Detachment in Exudative
Age related Macular Degeneration. Gabriel J.
Coscas, F. Coscas, E. H. Souied. Department of
Ophthalmology, Creteil Eye Clinic Univ Hospital,
Creteil, France *CR
3600 — D0329 Retinal thickness and volume
measured with the enhanced depth imaging
optical coherence tomography in normal eyes
and in eyes with chorioretinal disorders. Sung
Yong Park1, S. Kim1, Y. Song2, J. Sung3, 4, D.
Ham1. 1Ophthalmology, Samsung Medical Center,
Sungkyunkwan University School of Medicine,
Seoul, Democratic People’s Republic of Korea;
2
Family Medicine, Samsung Medical Center, and
Center for Clinical Research, Samsung Biomedical
Research Institute, Sungkyunkwan University
School of Medicine, Seoul, Democratic People’s
Republic of Korea; 3Epidemiology, Environment
and Health, School of Public Health, Seoul
National University, Seoul, Democratic People’s
Republic of Korea; 4Genomic Medicine, Medical
Research Center, Seoul National University, Seoul,
Democratic People’s Republic of Korea
3601 — D0330 Outer retinal structure in OCT
and microperimetry. Suqin Yu. Ophthalmology,
Shanghai Jiaotong University Affiliated Shanghai
First People’s Hospital, Shanghai, China
3602 — D0331 Predicting the Visual Acuity
of Patients with Diabetic Macular Edema from
the Measured Disruption Status of External
Limiting Membrane on the SD-OCT Scan.
Hrvoje Bogunovic1, M. D. Abramoff2, 3, E. H.
Sohn2, M. Sonka1, 2. 1Electrical and Computer
Engineering, The University of Iowa, Iowa City,
IA; 2Ophthalmology and Visual Sciences, The
University of Iowa, Iowa City, IA; 3Center for the
Prevention and Treatment of Visual Loss, Iowa City
VA Health Care System, Iowa City, IA *CR
3603 — D0332 Test-retest variability of
microperimetry in patients with type 2 idiopathic
macular telangiectasia. Evan N. Wong1, I.
Constable1, 2, F. K. Chen1, 2. 1Lions Eye Institute,
Perth, WA, Australia; 2Centre of Ophthalmology
and Vision Science, University of Western Australia,
Perth, WA, Australia *CR
3604 — D0333 Comparison of main OCT
features of Type 2 macular telangiectasia
in time- and spectral domain OCTs. Tunde
Peto1, I. Leung2, F. B. Sallo2, 3, D. Florea5, 6, A.
C. Bird4, 1. 1Reading Centre, NIHR Biomedical
Research Centre for Ophthalmology at Moorfields
Eye Hospital and Institute of Ophthalmology,
London, United Kingdom; 2Department of
Research and Development, Moorfields Eye
Hospital NHS Foundation Trust, London,
United Kingdom; 3Visual Neuroscience, UCL
Institute of Ophthalmology, London, United
Kingdom; 4Inherited Eye Disease, UCL Institute
of Ophthalmology, London, United Kingdom;
5
ORBIT, UCL Institute of Ophthalmology, London,
United Kingdom; 6Physiology, University of
Granada, Granada, Spain
3605 — D0334 A comparison of
microperimetry parameters derived from
the CenterVue MAIA and Nidek MP1S
instruments in subjects with type 2 idiopathic
macular telangiectasia (MacTel). Fred K.
Chen1, 2, I. Constable1, E. N. Wong3. 1Ocular Tissue
Engineering Lab, Ctr for Ophthal & Visual Sci,
UWA, Nedlands, WA, Australia; 2Ophthalmology,
Royal Perth Hospital, Perth, WA, Australia;
3
Molecular Ophthalmology, Lions Eye Institute,
Perth, WA, Australia *CR
3606 — D0335 Microscopic Retinal Structure
in Macular Telangiectasia. Austin Roorda1,
B. J. Lujan1, K. Ratnam1, V. J. Liu2, J. Tam3, S.
D. Schwartz4, A. Kaines4, P. S. Bernstein5, Y.
Zhang6, J. L. Duncan7. 1School of Optometry,
University of California, Berkeley, Berkeley,
CA; 2Dept of Bioengineering, University of
California, Berkeley, Berkeley, CA; 3Institut de
Ciències Fotòniques, Castelldefels, Spain; 4Jules
Stein Eye Institute, University of California, Los
Angeles, Los Angeles, CA; 5Moran Eye Center,
University of Utah School of Medicine, Salt Lake
City, UT; 6Dept of Ophthalmology, University of
Alabama, Birmingham, Birmingham, AL; 7Dept
of Ophthalmology, University of California, San
Francsico, San Francisco, CA *CR
3607 — D0336 Acute Macular
Neuroretinopathy: New Insights into
Pathogenesis and Association with Retinal
Capillary Ischemia. Ehsan Rahimy1, D.
Sarraf1, 2, A. A. Fawzi3, E. H. Sohn4, I. A.
Barbazetto5, 6, D. N. Zacks7, R. A. Mittra8,
S. Mrejen5, 6, N. R. Goldberg9, K. Freund5, 6.
1
Ophthalmology, Jules Stein Eye Institute, UCLA,
Los Angeles, CA; 2Greater LA VA Healthcare
Center, Los Angeles, CA; 3Ophthalmology, Feinberg
School of Medicine, Northwestern University,
Chicago, IL; 4Ophthalmology, University of
Iowa Hospital, Iowa City, IA; 5Vitreous Retina
Macula Consultants of New York, New York, NY;
6
Ophthalmology, New York University School of
Medicine, New York, NY; 7Ophthalmology, Kellogg
Eye Center, University of Michigan, Ann Arbor,
MI; 8VitreoRetinal Surgery, PA, Minneapolis, MN;
9
Ophthalmology, Mount Sinai School of Medicine,
New York, NY *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
241
Tuesday Posters
11:00 am – 12:45 pm
3593 — D0322 Imaging of Human Retina
using Spectral Optical Coherence Tomography
and high sensitive autofluorescence detection.
Katarzyna Komar, P. Stremplewski, M.
Szkulmowski, M. Motoczynska, M. Wojtkowski.
Institute of Physics, Faculty of Physics, Astronomy
and Informatics, Nicolaus Copernicus University,
Torun, Poland
3598 — D0327 Progression of Atrophy
Following Intravitreal anti-VEGF for Exudative
AMD. Kyung Hoon Seo1, S. Lee1, M. Kim2, S.
Yu1, H. Kwak1. 1Ophthalmology, Kyung Hee
University Hospital, Seoul, Republic of Korea;
2
Ophthalmology, Kangwon National University
Hospital, Chuncheon, Republic of Korea
3608 – 3633 – Tuesday – Posters
3608 — D0337 Comparison of retinal layer
thickness of normal eyes and eyes with diabetic
macular edema receiving ranibizumab. Zubir S.
Rentiya, Y. J. Sepah, M. A. Ibrahim, M. A. Sadiq, M.
Hassan, S. Kherani, H. Jang, R. Sophie, D. V. Do,
Q. Nguyen. Retinal Imaging Research and Reading
Center, Wilmer Eye Institute, Johns Hopkins
University, Baltimore, MD *CR
3609 — D0338 En-face optical coherence
tomography of ocular toxoplasmosis. Andre C.
Romano, R. Belfort. Ophthalmology, UNIFESPPaulista School of Med, Americana, Brazil *CR
3610 — D0339 Foveal Pit Dimensions in
Myopia. Rhett Stroupe, N. J. Coletta. New England
College of Optometry, Boston, MA
3611 — D0340 Peripapillary And Macular
Changes Detected by SD OCT in Eyes With High
Myopia. Leila El Matri, A. Chebil, B. Ben Achour,
Y. Falfoul, M. Bouladi. Ophthalmology, Institute of
Ophthalmology, Tunis, Tunisia
Tuesday Posters
11:00 am – 12:45 pm
3612 — D0341 Measuring Macula Hole Size
on Optical Coherence Tomography; Inter and
Intra Observer Agreement. Philip J. Banerjee,
M. A. Elgohary, L. Wickham, D. G. Charteris.
Vitreoretinal, Moorfields Eye Hospital, London,
United Kingdom
3613 — D0342 Optical coherence tomography
findings as prognostic factor in idiopathic
epiretinal membrane surgery. Itzel Espinosa, A.
Saucedo, A. Ramírez. Fundación Hospital Nuestra
Señora de la Luz, Mexico city, Mexico
3614 — D0343 Analysis of Epiretinal
Membranes Using Spectral Domain Optical
Coherence Tomography (OCT). Ajay E. Kuriyan,
D. DeBuc, W. E. Smiddy. Bascom Palmer Eye
Institute, Univ of Miami/Miller School of Medicine,
Miami, FL *CR
3615 — D0344 Correlation of Preoperative
Retinal Pigment Epithelium Status with Foveal
Microstructure in Repaired Macular Holes.
Michele Reibaldi1, T. Avitabile1, A. Longo1, F. Marco
Livio1, V. Bonfiglio1, S. Faro1, F. Viti2, A. Saitta1, M.
Nicolai1, C. Mariotti2. 1Ophthalmology, University
of Catania, Catania, Italy; 2Ophthalmology,
University of Ancona, Ancona, Italy
3616 — D0345 Acute central retinal vein
occlusion followed by disc edema: a frequent
cause of macular thickening without macular
edema. Feng Liang, J. Girmens, J. A. Sahel, M.
Paques. Departement IV, National Hospital of
Ophthalmology of 15-20, Paris, France *CR
3617 — D0346 Assessment of Cirrus™
OCT Registration in Macular Edema from
Diabetes or Retinal Vein Occlusion. Voraporn
Chaikitmongkol1, 2, M. K. Durbin3, S. B. Bressler1,
N. M. Bressler1. 1Wilmer Eye Institute, Johns
Hopkins University, Baltimore, MD; 2Department
of Ophthalmology, Chiang Mai University, Chiang
Mai, Thailand; 3Carl Zeiss Meditec Inc., Dublin,
CA *CR
3618 — D0347 Optical Coherence Tomography
Predicts Visual Outcome after Acute Retinal
Ischemia due to Central Retinal Vein Occlusion.
Suk Ho Byeon1, 2, J. Ko1, 2. 1Ophthalmology, Yonsei
Univ College of Medicine, Seoul, Republic of
Korea; 2Institute of vision research, Seoul, Republic
of Korea
3626 — D0355 The Value of Retinal Imaging
and Functional Testing of Patients with
Stargardt Disease. Robert Chun1, F. T. Collison1,
M. May1, G. A. Fishman1, 2. 1Pangere Center, The
Chicago Lighthouse for the Blind, Chicago, IL;
2
Ophthalmology, University of Illinois at Chicago,
Chicago, IL
3619 — D0348 OCT Analysis of Recurrent
Fluid after Intravitreal Therapy for Macula
Edema secondary to Central Retinal Vein
Occlusion. Stephen Holland1, D. G. Dodwell1, 2.
1
Southern Illinois University School of Medicine,
Springfield, IL; 2Illinois Retina Center, Springfield,
IL *CR
3627 — D0356 Outer Retinal Structure
Following Closed Globe Blunt Ocular Trauma.
John Flatter1, M. Dubow4, 2, R. S. Singh1, N.
Shah2, S. Robison1, D. V. Weinberg1, K. E.
Stepien1, A. Dubra1, 3, R. B. Rosen2, J. Carroll1, 3.
1
Ophthalmology, Medical College of Wisconsin,
Milwaukee, WI; 2Ophthalmology, New York Eye &
Ear Infirmary, New York, NY; 3Biophysics, Medical
College of Wisconsin, Milwaukee, WI; 4Mount
Sinai School of Medicine, Mount Sinai Hospital,
New York, NY *CR
3620 — D0349 Extrafoveal Changes Following
Intravitreal Bevacizumab Injections for
Macular Edema Secondary to Branch Retinal
Vein Occlusion: A mfERG and OCT Study.
Young-Hoon Ohn, J. Hyun, S. Park, T. Park.
Soonchunhyang university hospital, Bucheon,
Republic of Korea
3621 — D0350 Improved repeatability of
retinal thickness measurements using LSO
image-based retinal tracking. Jennifer Hu1,
C. B. Gottlieb1, D. Barajas1, C. J. Barnett1, T.
Schoenholz1, M. K. Durbin2, H. Iyer2, S. Sadda1.
1
Ophthalmology, University of Southern California
- Doheny Eye Institute, Los Angeles, CA; 2R&D,
Carl Zeiss Meditec, Inc, Dublin, CA *CR
3622 — D0351 Retinal thickness with posterior
pole analysis and its association with axial length
and body height. Takehiro Yamashita, Y. Kii, M.
Tanaka, K. Nakao, T. Sakamoto. Ophthalmology,
Kagoshima University, Kagoshima-Shi, Japan f
3623 — D0352 Statistical correlation analysis
between the retinal layer intensity ratios,
the quality of the image, and the subject age
based on 3D OCT Images. Xinjian Chen1, P.
Hou2, C. Jin1, W. Zhu1, F. Shi1, H. Chen2. 1School
of Electronics and Information Engineering,
Soochow University, Suzhou, China; 2Joint Shantou
International Eye Center, Shantou University and
the Chinese University of Hong Kong, Shantou,
China
3624 — D0353 A Comparison of ShortWavelength (488nm) and Near-infrared (787nm)
Autofluorescence in Stargardt’s Disease. Winston
Lee1, T. Duncker1, F. C. Delori2, R. Allikmets1, 3, J. R.
Sparrow1, 3. 1Ophthalmology, Columbia University,
New York, NY; 2Ophthalmology, Schepens Eye
Research Institute, Cambridge, MA; 3Pathology and
Cell Biology, Columbia University, New York, NY
3625 — D0354 Correlation of functional and
morphological data in Stargardt’s disease. Birgit
Lorenz, S. Stieger, W. Bowl, K. Stieger. Department
of Ophthalmology, Justus-Liebig University
Giessen, Giessen, Germany *CR
3628 — D0357 Relationship between Dry
Retinal Volume and Visual Acuity in Cystoid
Macular Edema. Muneeswar Gupta Nittala, Z. Hu,
S. R. Sadda. Ophthalmology, Doheny Eye Institute,
Los Angeles, CA *CR
3629 — D0358 Best Frames Selection
and Montaging in Wide-field ROP Images.
Alfredo Ruggeri, E. Poletti. Dept of Information
Engineering, University of Padua, Padua, Italy
3630 — D0359 Macular Retinal Thickness
in Moderately to Late Preterm School Aged
Children. Lina H. Raffa1, 2, J. Dahlgren1,
A. Karlsson1, M. A. Gronlund1. 1Pediatric
Ophthalmology, Queen Silvia Children’s Hosp,
Sahlgrenska, Gothenburg, Sweden; 2Ophthalmology
Department, King Abdulaziz University Hospital,
Jeddah, Saudi Arabia
3631 — D0360 Applications of Posterior
Segment Optical Coherence Tomography (OCT)
in Pediatric Ophthalmology. Sharel C. Ongchin,
D. A. Sim, R. Smith, P. A. Keane, D. Thomas.
Ophthalmology, Moorfields Eye Hospital, London,
United Kingdom
3632 — D0361 Retinal Optical Coherence
Tomography in Sickle Cell Disease. Vasco T.
Bravo-Filho1, F. B. Vilar1, T. Martins1, S. De
Biase1, J. L. Andrade1, A. S. Araújo2, T. E. Arantes1.
1
Ophthalmology, Altino Ventura Foundation, Recife,
Brazil; 2Haematology, HEMOPE, Recife, Brazil
3633 — D0362 Retinal Thickness, Retinal Point
Sensitivity and Inner Segment/Outer Segment
Photoreceptor (IS/OS) Status after Treatment
with Ranibizumab in Patients with Diabetic
Macular Edema. Millena G. Bittencourt, D. A.
Ferraz, J. Yohanan, O. O. Agbedia, M. A. Sadiq,
Y. J. Sepah, M. A. Ibrahim, R. Sophie, M. Hanout,
Q. Nguyen. Retina Imaging Research and Reading
Center, Wilmer Eye Institute, Johns Hopkins
University, Baltimore, MD *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
242
Tuesday – Posters – 3634 – 3650
3634 — D0363 The cone outer segment
termination (COST) line appears abnormal
on OCT scans of patients with stationary and
progressive forms of cone dysfunction. Ari D.
Schuman1, R. Ramachandran1, X. Zhang1, D. G.
Birch3, D. C. Hood1, 2. 1Psychology, Columbia
University, New York, NY; 2Ophthalmology,
Columbia University, New York, NY; 3Retina
Foundation of Southwest, Dallas, TX *CR
3635 — D0364 Reticular Pattern Dystrophy:
A Spectral-Domain Optical Coherence
Tomography Analysis. Jennyfer Zerbib, G.
Querques, N. Massamba, N. Puche, J. Tilleul, F.
Lalloum, M. Srour, E. H. Souied. Ophthalmology,
Centre Hospitalier Intercommunal Creteil,
Université Paris Est creteil, Creteil, France *CR
3636 — D0365 Prevalence and Associations of
Incomplete Posterior Vitreous Detachment in
Adult Chinese: the Beijing Eye Study. Lei Shao1, 2,
W. Wei1, 2. 1Beijing Tongren Eye Center, Beijing
Tongren Hospital, Beijing, China; 2Beijing Institute
of Ophthalmology, Beijing Tongren Hospital,
Beijing, China
3637 — D0366 Depth Resolved Enface Imaging
of Inner Retinal Pathologies and Photoreceptor
Integrity in Diabetic Retinopathy. Andrew
W. Francis, J. Wanek, J. I. Lim, M. Shahidi.
Ophthalmology and Visual Sciences, University of
Illinois at Chicago, Chicago, IL *CR
Exhibit Hall D0384-D0395
Tuesday, May 07, 2013 11:00 AM-12:45 PM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology
350 Strabismus: Detection and
Quality of Life
Moderator: Jonathan M. Holmes
3639 — D0384 Factors related to strabismus
decompensation after prolonged stability.
Eldad Adler, Y. Kim, R. Siatkowski. Department of
Ophthalmology, University of Oklahoma / Dean
McGee Eye Institute, Oklahoma City, OK
3640 — D0385 Clinical features and surgical
outcome of strabismus in periventricular
leukomalacia. Hee-Young Choi1, 2, J. Jung1, 2.
1
Pusan National Univ. Hospital, Busan, Republic of
Korea; 2Ophthalmology, Medical research institute,
BUSAN, Republic of Korea
3650 — D0395 Accuracy of Double Maddox
Rod Testing with Variable Prism Induced
Hypertropia. Justin D. Marsh, B. Markowitz, A.
E. Hack. Ophthalmolology, University of South
Carolina, Columbia, SC
3642 — D0387 What Magnitude of Nondiplopic Strabismus Affects Health-Related
Quality of Life? David A. Leske, S. R. Hatt, L.
Liebermann, J. M. Holmes. Ophthalmology, Mayo
Clinic, Rochester, MN
3643 — D0388 Specific Aspects of FunctionRelated Quality of Life Improvement in NonDiplopic Patients After Strabismus Surgery.
Laura Liebermann, S. R. Hatt, D. A. Leske, J. M.
Holmes. Ophthalmology, Mayo Clinic, Rochester,
MN
3644 — D0389 Status of quality of life in adult
strabismus with corrective surgery: the longterm results. Xinping Yu. Eye Hospital of Wenzhou
Medical College, Wenzhou Medical College,
Wenzhou, China
3645 — D0390 Principal component analysis
of both AS-20 and A&SQ questionnaires in
110 subjects of the historic Waterland cohort.
Huibert J. Simonsz1, E. S. van de Graaf1, J. Felius2,
G. Borsboom3, H. Kelderman4. 1Ophthalmology,
ErasmusMC, Rotterdam, Netherlands; 2Retina
Foundation of the Southwest, Dallas, TX; 3Public
Health, ErasmusMC, Rotterdam, Netherlands;
4
Psychology, Free University, Amsterdam,
Netherlands
3646 — D0391 Clinical Characteristics and
Natural History of Convergence Insufficiency.
Rafif Ghadban, B. Mohney, J. Martinez-Thompson.
Mayo Clinic, Rochester, MN
3647 — D0392 Predictibility of relaxation test
and eye position under general anesthesia in
strabismus. Solange Milazzo1, 2, M. Benzerroug1,
D. Bremond-Gignac1. 1Ophthalmology/Saint Victor
Center, CHU Amiens, University Jules Verne,
Amiens, France; 2UPRES, EA 3801, Reims, France
3648 — D0393 Anisometropic Astigmatism
in Superior Oblique Palsy. Alexandra O.
Apkarian1, J. Shelton3, S. Nallasamy2. 1Pediatric
Ophthalmology, University of Michigan - WK
Kellogg Eye Center, Ann Arbor, MI; 2Pediatric
Ophthalmology, Children’s Hospital Los Angeles,
Los Angeles, CA; 3Intermountain Eye, Boise, ID
3649 — D0394 Wavelength dependence of the
Brückner red eye effect. Johan van Jole1, R. J. van
den Berg1, A. van Donkelaar1, J. van Dronkelaar1,
M. J. De Groot1, J. Coppens3, T. Berendschot4,
T. J. Van Den Berg3, H. J. Simonsz2. 1Mechanical
Engineering, Technical University Delft, Delft,
Netherlands; 2Opthalmology, erasmusmc,
Rotterdam, Netherlands; 3Nederlands Instituut voor
Neurowetenschappen, Amsterdam, Netherlands;
4
opthalmic physics, Maastricht University,
Maastricht, Netherlands *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
243
Tuesday Posters
11:00 am – 12:45 pm
3638 — D0367 Retinal Edema and Orbital
Blood Flow in Preeclampsia. Madlene Holmqvist1,
I. C. Gustafsson2, P. Wollmer3, S. R. Hansson1,
P. Schatz2. 1Department of Clinical Sciences,
Lund University, Lund, Sweden; 2Department of
Ophthalmology, Lund University, Lund, Sweden;
3
Department of Clinical Sciences, Lund University,
Malmö, Sweden
3641 — D0386 Surgical Outcomes
of Intermittent Exotropia with a High
Accommodation Convergence-Accommodation
Ratio. Hwan Heo, M. Sung, S. Park.
Ophthalmology, Chonnam National University
Medical School and Hospital, Gwangju, Republic
of Korea
Tuesday – Workshops/SIGs
TCC 305
6A
TCC 303
Tuesday, May 07, 2013 1:00 PM-2:30 PM
Tuesday, May 07, 2013 1:00 PM-2:30 PM
Tuesday, May 07, 2013 1:00 PM-2:30 PM
Nanotechnology and Regenerative Medicine
352 Clinician-Scientist Forum:
How to Become a Successful
Clinician-Scientist
353 Global Health and Vision
Research: The Future of International
Collaborations and Impacts
Clinician-scientists at various stages in their career
will share their experiences on how to become a
successful clinician-scientist. An NEI extramural
representative will be available to discuss clinicianscientist specific funding mechanisms.
Approximately 37 million people are blind globally,
and 124 million have low vision. This does not
include people with refractive errors. The main
causes of global blindness are cataract, glaucoma,
corneal disorders, age-related macular degeneration,
and diabetic retinopathy. With an aging population
and increased life expectancy 76 million people
are projected to be blind by 2020 necessitating
proactive international collaboration to formulate
deliverable approaches to beat and treat global
blindness. The Vision 2020 initiative launched
in 1999 has shown some notable achievements
in the prevention and management of avoidable
blindness. Most certainly more such efforts are
needed. Increasing international collaborations
on public awareness, professional, political, and
research levels are expected to have the greatest
impact on human health, quality of life and vision
research. The causes of blindness and visual loss
largely depend on socioeconomic conditions and
the availability of health and eye care services. Eye
care in Africa is particularly lacking and in many
Asian countries is inadequate. The Life-changing
International Research Symposium will concentrate
on establishing much-needed new active research
collaborations and accomplishments in vision
diagnostic, treatment and prevention between
developed and developing countries. The aims
of this global health symposium are to bring the
leaders of eye disease research and care delivery to
discuss the impacts their programs have made on
the global level and how these programs could be
used as models to expand the global collaborations
in scientific research and training.
351 Nanotechnology and Regenerative
Medicine Group: Minimally Invasive
Biometric Technology as a Means to
Improve Detection, Understanding, and
Treatment of Ocular Disease
The speakers will critically review the current
status of non-invasive monitoring of key indicators
of ocular disease status in the leading causes of
blindness (e.g., glaucoma, age-related macular
degeneration, diabetic retinopathy). Advances in
this field will play a critical role in the evolution
of regenerative medicine and health maintenance
technology. We will review progress in non-invasive
monitoring of mitochondrial function, intraocular
pressure, retinal blood flow, and photoreceptor
function in retinal disease and glaucoma.
Tuesday Workshops/SIGs
1:00 pm – 2:30 pm
Moderators: Victor M. Elner, Austin Roorda
and Robert Ritch
— 1:00 Mitochondrial Imaging in Diabetic
Retinopathy and Age-Related Macular
Degeneration. Victor M. Elner. Ophthalmology/
Pathology, Univ of Michigan-Kellogg Eye Ctr, Ann
Arbor, MI *CR
— 1:15 Use of Nanotechnology for Diagnosis
and Treatment of Diabetic Retinopathy. Gerard
A. Lutty. Wilmer Eye Inst, Johns Hopkins Univ Sch
of Med, Baltimore, MD
— 1:30 Use of Adaptive Optics Scanning
Laser Ophthalmoscopy and OCT to Monitor
Photoreceptors in Retinal Degenerative Diseases.
Jacque L. Duncan. Ophthalmology, Univ of
California - SF, San Francisco, CA
Moderators: Pedram Hamrah, Mark E. Pennesi
and Jaafar El Annan
— 1:00 Introduction: Paul Sieving, MD, PhD,
Director, NEI/NIH
— 1:10 The Clinician Scientist Career
from an Asian Perspective. Shigeru Kinoshita.
Ophthalmology, Kyoto Prefectural Univ of Med,
Kamigyo-Ku, Japan *CR
— 1:20 Advice for Emerging Clinician
Scientists. Joan M. O’Brien. Department of
Ophthalmology, University of Pennsylvania,
Philadelphia, PA
— 1:30 Opportunities and Challenges of
Academic Ophthalmologist. Natalie A. Afshari.
Ophthalmology, University of California San Diego,
La Jolla, CA
— 1:40 Translational research of the Paris
Vision Institute and the French National
Ophthalmology Hospital. Jose A. Sahel. UMR-S
968, Institut de la Vision, Paris, France *CR
— 1:50 Research and Career Development
Opportunities at NEI. Neeraj Agarwal. NEI, NIH,
Boyds, MD
— 2:00 Panel Discussion
— 1:45 Clinical experience in using
Triggerfish® for the recording of the 24-hour IOP
pattern. Rene Goedkoop. Clinical Development
and Medical Affairs, Sensimed SA, Lausanne,
Switzerland *CR
Moderators: Gyan Prakash and Rajiv R. Mohan
— 1:00 Introduction: Promoting International
Eye Research - Paul Sieving, MD, PhD, Director,
NEI/NIH
— 2:00 OCT-Based ONH and Retinal Blood
Flow for Early Diagnosis of Glaucoma. David
Huang. Casey Eye Institute, Oregon Health &
Science Univ, Portland, OR *CR
— 1:12 Changing Lives with Open Eyes.
International research collaboration with Open
Source Systems. Peng T. Khaw. NIHR Biomed Res
Centre Moorfields UCL Inst Ophth, London, United
Kingdom *CR
— 2:15 Panel Discussion
— 1:24 US-UK Collaborative Research-UNITE
Program. Robert B. Nussenblatt. National Eye Inst/
NIH, Bethesda, MD
— 1:36 Restoring Vision in Blind Children Indo-US Collaboration. Pawan Sinha. Brain and
Cognitive Sciences, MIT, Cambridge, MA
— 1:48 The Role of Non-human Primates in
Global Eye Research. Paul D. Gamlin. Vision
Sciences, Univ of Alabama at Birmingham,
Birmingham, AL
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
244
Tuesday – Workshops/SIGs
— 2:00 Keys to a Successful Eye Research
Collaboration in China: Opportunities and
Challenges. David S. Friedman. Ophthalmology,
Johns Hopkins Wilmer Eye Inst, Baltimore, MD
*CR
— 2:12 Discussion: Roadmap for Research and
International Collaborations
TCC 304
Tuesday, May 07, 2013 1:00 PM-2:30 PM
354 Smartphones in Ophthalmology
Moderators: Simon Kaja and Vinay A. Shah
— 1:00 Introduction
— 1:05 Smartphones. Michael A. Cassell.
Ophthalmology, University of Missouri - Kansas
City, Shawnee, KS
— 1:20 Smartphones as Clinical Tools. Vinay A.
Shah. Ophthalmology, Dean McGee Eye Inst, Univ
of Oklahoma, Oklahoma City, OK *CR
— 1:35 Smartphone Applications for Vision
Research. Simon Kaja. Ophthalmology, Univ of
Missouri-Kansas City, Kansas City, MO
608
Tuesday, May 07, 2013 1:00 PM-2:30 PM
Tuesday, May 07, 2013 1:00 PM-2:30 PM
Cornea / Anatomy/Pathology / Clinical/
Epidemiologic Research / Glaucoma /
Immunology/Microbiology / Physiology/
Pharmacology
Cornea
355 Translational Aspects of
Anti(lymph) Angiogenic Therapy at the
Ocular Surface - SIG
Basic scientists and clinician scientists will discuss
new insights on the pathogenetic role of (lymph)
angiogenesis in dry eye, corneal transplant rejection,
ocular tumors and glaucome wound healing. In
addition new treatment concepts, sideeffects, study
design and early clinical experiences are outlined.
Moderator: Claus Cursiefen
— SIG Organizer. Claus Cursiefen. Dept of
Ophthalmology, University of Cologne, Koln,
Germany *CR
— Antilymphangiogenic therapy in corneal
transplantation. Claus Cursiefen. Dept of
Ophthalmology, University of Cologne, Koln,
Germany *CR
356 Endothelial Dysfunction: From
Pathophysiology to Treatment - SIG
Manipulation of endothelial cells prior to, in the
context of or instead of transplantation is feasible.
To pave the road towards novel therapies the SIG
reviews endothelial pathology and options for
therapies to stimulate discussion between basic
scientists and clinicians.
Moderators: Friedrich E. Kruse and
Shigeru Kinoshita
— SIG Organizer. Friedrich E. Kruse. Department
of Ophthalmology, University of Erlangen
Nurnberg, Erlangen, Germany
— SIG Organizer. Shigeru Kinoshita.
Ophthalmology, Kyoto Prefectural Univ of Med,
Kamigyo-Ku, Japan *CR
— Introduction. Friedrich E. Kruse. Department
of Ophthalmology, University of Erlangen
Nurnberg, Erlangen, Germany
— Novel anti (lymph) angiogenic treatment
options for ocular surface tumors. Ludwig M.
Heindl. Department of Ophthalmology, University
of Cologne, Cologne, Germany
— Intercellular junction proteins as treatment
targets in corneal endothelial disease. Frank
Larkin. Moorfields Eye Hospital, London, United
Kingdom
— Antilymphangiogenic therapy in dry eye
disease. Reza Dana. Ophthalmology, Mass Eye &
Ear Infirmary/HMS, Boston, MA *CR
— Basement membrane proteins as targets in
corneal endothelial disease. Julia M. Wessel.
Department of Ophthalmology, University Hospital
Erlangen, Erlangen, Germany
— Antiangiogenic therapy in filtering
glaucoma surgery. Ashkan Khalili. Ocular
Repair & Regeneration Biol, UCL Institute of
Ophthalmology, London, United Kingdom *CR
— Neurotoxic effects of vegf depletion at the
ocular surface. Mark Rosenblatt. Ophthalmology,
Weill Cornell Medical College, New York, NY
— 1:45 Discussion
— Candidate and high throughput drug
screening for Fuchs dystrophy. Albert S. Jun.
Ophthal-Smith 5011, Johns Hopkins Wilmer Eye
Inst, Baltimore, MD *CR
— Mitochondrial dysfunction as a novel
therapeutic target in Fuchs Endothelial Conreal
Dystrophy. Ula V. Jurkunas. Ophthalmology/
Harvard Med Sch, MA Eye & Ear Infirm Schepens
Eye Res, Boston, MA *CR
— Cell-injection Therapy as a New Therapeutic
Modality for Corneal Endothelial Diseases.
Noriko Koizumi. Biomedical Engineering, Doshisha
University, Kyotanabe City, Japan
— Looking into the future: Protecting
endothelial cells by non-viral/viral transfection
with DNA and RNA. Thomas A. Fuchsluger.
Department of Ophthalmology, Heinrich-HeineUniv Duesseldorf, Duesseldorf, Germany
— Summary and conclusion. Shigeru Kinoshita.
Ophthalmology, Kyoto Prefectural Univ of Med,
Kamigyo-Ku, Japan *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
245
Tuesday Workshops/SIGs
1:00 pm – 2:30 pm
The purpose of this workshop is to present valuable
uses of and novel applications for smartphones
relevant to all aspects of ophthalmology. Given
the significant advances in mobile communication
in recent years, smartphones and smartphone
applications have changed the field of medicine,
including ophthalmology. In this workshop, we
will focus on the power of smartphone applications
to serve as clinical tools, contribute to ophthalmic
education, aid vision research and enhance personal
and professional efficiency. Applications that
can help ophthalmologists with marketing and
branding their practice to both patients and their
referring physicians will also be discussed. The
goal of this workshop is to provide the attendee
a broad perspective of the utility of smartphones
and smartphone applications not only relevant to
ophthalmology but also to everyday life.
606/607
Tuesday – Workshops/SIGs
611-614
615-617
Tuesday, May 07, 2013 1:00 PM-2:30 PM
Tuesday, May 07, 2013 1:00 PM-2:30 PM
Retina / Biochemistry/Molecular Biology /
Immunology/Microbiology / Visual
Psychophysics / Physiological Optics
Clinical/Epidemiologic Research / Glaucoma /
Retina / Visual Psychophysics /
Physiological Optics
357 Antioxidants and AMD:
Into the Mechanisms - SIG
358 Visual Function Clinical Trial
Endpoints - SIG
This symposium will discuss the anti-oxidant and
anti-inflammatory mechanisms of nutrients like
zinc and lutein and their role in the prevention
and treatment of AMD. The speakers will cover
these topics from a basic science perspective, with
expansion to daily practice.
Moderators: Tos TJM Berendschot and
Carel B. Hoyng
— SIG Organizer. Tos TJM Berendschot.
University Eye Clinic Maastricht, Maastricht,
Netherlands
— SIG Organizer. Carel B. Hoyng.
Ophthalmology, Nijmegen Univ Medical Center,
Nijmegen, Netherlands
Tuesday Workshops/SIGs
1:00 pm – 2:30 pm
— Zinc and the complement system. B Klevering.
Ophthalmology, Radboud University Medical
Centre Nijmegen, Nijmegen, Netherlands
— Lutein and the complement system. Aize
Kijlstra. University Eye Clinic, Maastricht
University, Maastricht, United Kingdom
— Lutein and Zeaxantin as protective agents
against AMD. John Paul P. SanGiovanni. Clinical
Trials Branch, National Eye Institute/NIH,
Bethesda, MD
— Lutein binding proteins in the macula. Paul
S. Bernstein. Ophthal and Visual Sciences, Univ of
Utah/Moran Eye Center, Salt Lake City, UT *CR
— Anti-inflammatory effects of lutein. Amy C.
Lo. Department of Ophthalmology, University of
Hong Kong, Hong Kong, Hong Kong
The purpose of this SIG is to develop a consensus
around the validation of novel clinical trial
endpoints based upon visual function for age-related
degeneration, diabetic retinopathy, glaucoma, and
other retinal diseases.
Moderators: Gregory R. Jackson and
Stela Vujosevic
— SIG Organizer. Gregory R. Jackson.
Ophthalmology, Penn State College of Medicine,
Hershey, PA *CR
— Visual field and related endpoints for
multicenter clinical trials and the importance of
using reading centers. Chris A. Johnson. Ophthal &
Visual Sci, University of Iowa, Iowa City, IA *CR
— Glaucoma clinical regulatory endpoints
for Non IOP therapies. Barbara M. Wirostko.
Ophthalmology, University of Utah, Park City, UT
*CR
— Qualifying functional biomarkers as fitfor-purpose. Mitchell G. Brigell. Translational
Medicine, Novartis Inst for Biomed Rsrch,
Cambridge, MA *CR
618-620
Tuesday, May 07, 2013 1:00 PM-2:30 PM
Retina / Anatomy/Pathology / Biochemistry/
Molecular Biology / Glaucoma / Immunology/
Microbiology / Physiology/Pharmacology /
Retinal Cell Biology / Visual Psychophysics /
Physiological Optics
359 Emerging Strategies for In Vivo
Cellular and Molecular Imaging of
Retinal Disease - SIG
This session will focus on recent advances toward
cellular and molecular imaging of the retina in
health and disease, with emphasis on development
of optical imaging instrumentation and optical
contrast agents for retinal imaging.
Moderators: Ashwath Jayagopal and
Mark E. Kleinman
— SIG Organizer. Ashwath Jayagopal. Vanderbilt
Eye Institute, Vanderbilt University Medical Center,
Nashville, TN
— SIG Organizer. Mark E. Kleinman.
Ophthalmology & Visual Sci, Univ of Kentucky,
Lexington, KY
— Detection of apoptosing retinal cells (DARC)
and imaging retinal neurodegeneration.
M. Francesca Cordeiro. Glaucoma & Retinal
Neurodegnrtn Res Grp, UCL Inst Ophthal & Western
Eye Hsp London, London, United Kingdom *CR
— Imaging strategies to monitor retinal pigment
epithelial cell death in vivo. Mark E. Kleinman.
Ophthalmology & Visual Sci, Univ of Kentucky,
Lexington, KY
— Topical endoscopic fundus imaging (TEFI)
of the retina in normal and diseased mice.
Joao M. Furtado. Paulista Sch of Med, Dept of
Ophthalmology, Federal University of Sao Paulo,
Sao Paulo, Brazil
— In vivo imaging of protein and RNA
biomarkers in retinal vascular disease. Ashwath
Jayagopal. Vanderbilt Eye Institute, Vanderbilt
University Medical Center, Nashville, TN
— Multimodal structural and functional imaging
of the retina using the MICRON III imaging
system. Norbert A. Massie. Phoenix Research
Laboratories, Pleasanton, CA *CR
TCC LL 4/5
Tuesday, May 07, 2013 1:00 PM-2:30 PM
Retinal Cell Biology / Anatomy/Pathology /
Immunology/Microbiology / Retina
360 Microglia in Retinal Disease:
A Cellular Target for Therapy? - SIG
How microglia contribute to physiological
functioning of the retina and how they are involved
in retinal pathologies have been areas of recent
study. This SIG will discuss evidence for their
participation in retinal disease and explore how
microglia can constitute a cellular target for future
therapeutic approaches.
Moderator: Wai T. Wong
— SIG Organizer. Wai T. Wong. Unit on NeuronGlia Interactions, National Eye Institute, Bethesda,
MD
— Microglia in the normal and aging retina. Wai
T. Wong. Unit on Neuron-Glia Interactions, National
Eye Institute, Bethesda, MD
— Microglia in inherited and light-induced
retinal degeneration. Thomas Langmann.
Department of Ophthalmology, University of
Cologne, Cologne, Germany
— Microglia in diabetic retinopathy. Paul G.
McMenamin. Dept of Anatomy & Dev Biology,
Monash University, Melbourne, VIC, Australia
— Microglia in age-related macular
degeneration. Florian Sennlaub. Institut de la
Vision, UMRS 986, University Pierre et Marie
Curie, Paris, France
— Microglia and complement activation. Matt
V. Rutar. The Australian National University,
Canberra, ACT, Australia
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
246
Tuesday – Papers/Minisymposium – 3651 – 3663
6A
Tuesday, May 07, 2013 2:45 PM-4:30 PM
Biochemistry/Molecular Biology
362 Biochemistry and Regulation of
Proteins in AMD
Moderators: Thomas P. Sauer and
Tiarnan D. Keenan
3651 — 2:45 Age-Dependent Changes In
Heparan Sulfate In Human Bruch’s Membrane:
Implications For Age-Related Macular
Degeneration. Tiarnan D. Keenan1, 4, C. Pickford2,
R. Holley2, 3, S. J. Clark1, 4, C. Merry2, A. J. Day3,
P. N. Bishop1, 4. 1Faculty of Medical and Human
Sciences, University of Manchester, Manchester,
United Kingdom; 2Faculty of Engineering and
Physical Sciences, University of Manchester,
Manchester, United Kingdom; 3Faculty of Life
Sciences, University of Manchester, Manchester,
United Kingdom; 4Centre for Advanced Discovery
and Experimental Therapeutics, Manchester
Academic Health Sciences Centre, Manchester,
United Kingdom
3653 — 3:15 p62, regulated by Nrf2 signaling,
is a key factor in autophagic protection in
retinal pigment epithelial (RPE) cells. Lei
Wang, K. B. Ebrahimi, M. D. Cano, J. T. Handa.
Ophthalmology, Johns Hopkins Univ School of
Med, Baltimore, MD *CR
3654 — 3:30 Exosomal Proteins in the Aqueous
Humor as Novel Biomarkers in Patients with
Neovascular Age-related Macular Degeneration.
Hyewon Chung1, 2, A. Choi1, E. Lee1, G. Kang3, S.
Choi4, H. J. Lim4. 1Ophthalmology, Konkuk Univ
School of Medicine, Seoul, Republic of Korea;
2
Konkuk Univ Medical Center, Seoul, Republic of
Korea; 3Diatech Korea Co., Ltd., Seoul, Republic of
Korea; 4Biomedical Science & Technology, Konkuk
Univ, Seoul, Republic of Korea
3656 — 4:00 DICER1 is regulated via cAMP
in an EPAC/Rap1-dependent manner in human
retinal pigment epithelial cells - implications
for age-related macular degeneration. Thomas
P. Sauer, S. Kurth, F. G. Holz, T. U. Krohne.
Ophthalmology, University of Bonn, Bonn,
Germany *CR
3657 — 4:15 Using extremes to identify rare
pathogenic variants in age-related-macular
degeneration. Codrut C. Paun1, 2, D. Smailhodzic1,
C. J. Boon1, L. H. Hoefsloot2, M. R. Daha3, C. B.
Hoyng1, A. I. Den Hollander1, 2. 1Ophthalmology,
Radboud Univ Nijmegen Med Ctr, Nijmegen,
Netherlands; 2Human Genetics, Radboud University
Nijmegen Medical Centre, Nijmegen, Netherlands;
3
Nephrology, Leiden University Medical Center,
Leiden, Netherlands
6E
Tuesday, May 07, 2013 2:45 PM-4:30 PM
Retina
363 AMD: Morphology and
Novel Risk Factors
Moderators: Milam A. Brantley and Ruth E. Hogg
3658 — 2:45 Geographic atrophy risk factors
in participants of the Comparison of Agerelated Macular Degeneration Treatments
Trials (CATT). Juan E. Grunwald1, E. Daniel1,
G. Ying1, J. Huang1, G. J. Jaffe2, C. A. Toth2, S.
A. Hagstrom3, S. L. Fine4, D. F. Martin3, M. G.
Maguire1. 1Ophthal-Scheie Eye Inst, Univ of
Pennsylvania, Perelman Sch of Med, Philadelphia,
PA; 2Ophthalmology, Duke University, Durham,
NC; 3Ophthalmology, Cole Eye Institute, Cleveland
Clinic, Cleveland, OH; 4Ophthalmology, University
of Colorado, Denver, CO *CR, f
3659 — 3:00 Sustained Severe Visual Acuity
Loss in the Comparison of AMD Treatments
Trials (CATT). Gui-Shuang Ying1, B. J. Kim1, M.
G. Maguire1, J. Huang1, E. Daniel1, G. J. Jaffe2,
D. F. Martin3, J. E. Grunwald1. 1Ophthalmology,
Scheie Eye Institute, Philadelphia, PA;
2
Ophthalmology, Duke University Medical Center,
Durham, NC; 3Cole Eye Institute, Cleveland Clinic,
Cleveland, OH *CR, f
3660 — 3:15 The Relationship between
Haemorrhage and OCT Signs and the
Likelihood of Neovascular AMD being Active
during Follow-up: Data from the IVAN study.
Simon P. Harding1, 6, B. C. Reeves3, A. Muldrew4,
D. G. Parry6, C. Rogers5, J. Sahni1, 6, T. Peto2, U.
Chakravarthy4. 1Eye and Vision Science, University
of Liverpool, Liverpool, United Kingdom; 2NIHR
Biomedical Research Centre for Ophthalmology,
Moorfields Eye Hospital NHS Foundation Trust and
UCL Institute of Ophthalmology, London, United
Kingdom; 3Clinical Trials and Evaluation Unit,
University of Bristol, Bristol, United Kingdom;
4
Institute of Clinical Science, Queen’s University
Belfast, Belfast, United Kingdom; 5Health
Economics Research Centre, Department of Public
Health, University of Oxford, Oxford, United
Kingdom; 6St. Paul’s Eye Unit, Royal Liverpool
University Hospital, Liverpool, United Kingdom
*CR, f
3661 — 3:30 Risk Factors for Scarring
in the Comparison of Age-related Macular
Degeneration Treatments Trials (CATT).
Ebenezer Daniel1, 2, C. A. Toth4, 6, J. E. Grunwald1, 2,
D. F. Martin7, G. Ying3, 1, J. Huang3, G. J. Jaffe6, 5,
S. L. Fine8, M. G. Maguire1, 3. 1Department of
Ophthalmology, Perelman School of Medicine,
University of Pennsylvania, Philadelphia, PA;
2
Scheie Ophthalmology Reading Center, University
of Pennsylvania, Philadelphia, PA; 3Center for
Preventive Ophthalmology and Biostatistics,
University of Pennsylvania, Philadelphia, PA;
4
Department of Biomedical Engineering, Duke
University, Durham, NC; 5Duke Reading Center,
Duke University Eye Center, Durham, NC;
6
Department of Ophthalmology, Duke University,
Durham, NC; 7Cole Eye Institute, Cleveland
Clinic Foundation, Cleveland, OH; 8Department of
Ophthalmology, University of Colorado-Denver,
Aurora, CO *CR, f
3662 — 3:45 Metabolomic analysis in
patients with age related macular degeneration.
Sreekumari R. Pushpoth1, 2, M. A. Fitzpatrick2, S.
Young2, Y. C. Yang3, J. S. Talks1, G. R. Wallace2.
1
Ophthalmology, Royal Victoria Infirmary,
Newcastle upon tyne, United Kingdom;
2
Translational Inflammation Research, University
of Birmingham, Birmingham, United Kingdom;
3
Ophthalmology, The Royal Wolverhampton
Hospitals NHS Trust, Wolverhampton, United
Kingdom *CR, f
3663 — 4:00 Circulating Mesenchymal
Progenitor Cells in Patients with Neovascular
Age-Related Macular Degeneration. Scott W.
Cousins1, 2, P. S. Mettu1, T. Pridgen1, S. Crowell1,
M. Spiga1. 1Duke Eye Center/Ophthalmology,
Duke University School of Medicine, Durham, NC;
2
Immunology, Duke University School of Medicine,
Durham, NC *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
247
Tuesday Papers
Minisymposium
2:45 pm – 4:30 pm
3652 — 3:00 TREM2 (chr6p21.1) and CFH
(chr1q32) regulation by NF-kB-sensitive
miRNAs in age-related macular degeneration
(AMD) and Alzheimer’s disease (AD). Walter J.
Lukiw1, 2, B. M. Jones1, S. J. Bhattacharjee1, P. N.
Alexandrov2, P. Dua3, Y. Zhao1, 4. 1Neuroscience
& Ophthalmology, Lousiana State Univ Health
Sciences Center, New Orleans, LA; 2Russian
Academy of Medical Sciences, Moscow, Russian
Federation; 3Louisiana Technical University,
Ruston, LA; 4University of Texas Health Sciences
Center, Houston, TX
3655 — 3:45 Short-term exposure to thrombin
induces long lasting disruption of barrier
properties and proangiogenic signals in RPE.
Tami Livnat1, O. Bialer2, Y. Nisgav1, M. Dachbash1,
R. Dardik1, 3, D. Weinberger2, 4. 1Laboratory of Eye
Research, Felsenstein Medical Research Center,
PetachTikva, Israel; 2Department of Ophthalmology,
Rabin Medical Center, Petah Tiqwa, Israel; 3The
Israeli National Hemophilia Center and Institute of
Thrombosis and Hemostasis, Sheba Medical Center,
Tel Hashomer, Israel; 4Sackler School of Medicine,
Tel Aviv University, Tel Aviv, Israel
3664 – 3682 – Tuesday – Papers/Minisymposium
3664 — 4:15 Subclassification of clinicallyindistinguishable AMD patients based on
metabolic characteristics. Milam A. Brantley1,
Y. Park2, M. B. Parks1, L. Burgess1, K. Uppal2, P.
Sternberg1, D. P. Jones2. 1Vanderbilt Eye Institute,
Vanderbilt University, Nashville, TN; 2Department
of Medicine, Emory University, Atlanta, GA
606/607
Tuesday, May 07, 2013 2:45 PM-4:30 PM
Immunology/Microbiology
364 Hot Topics in Infection and
Immunity
Moderators: Heping Xu and James T. Rosenbaum
Tuesday Papers/
Minisymposium
2:45 pm – 4:30 pm
3665 — 2:45 Chemokine-mediated guidance
of the inflammatory response by Müller cells,
microglia, and RPE in an animal model of
atrophic AMD. Matt V. Rutar1, 2, R. Chia1, 2, R.
Natoli1, 2, J. M. Provis1, 2. 1John Curtin School
of Medical Research, The Australian National
University, Canberra, ACT, Australia; 2ARC Centre
of Excellence in Vision Science, The Australian
National University, Canberra, ACT, Australia *CR
3666 — 3:00 HtrA1 regulates the subretinal
infiltration of microglia cells in response to
bacterial lipopolysaccharides (LPS) and aging
in mice. Sha-Mei Liao, M. Crowley, S. Louie, O.
Delgado, N. Buchanan, M. Stefanidakis, B. D.
Jaffee. Ophthalmology, Novartis, Cambridge, MA
*CR
3667 — 3:15 A Functional Link Between the
Melanocortin and Adenosinergic Pathways in the
Expression of Protective Regulatory Immunity in
the Post-EAU Spleen. Darren J. Lee, A. W. Taylor.
Ophthalmology, Boston University School of Med,
Boston, MA
3668 — 3:30 Corneal infection induces
migration of dendritic cells with CD1a
expression. Mari Narumi1, Y. Kashiwagi3, H.
Namba1, R. Ohe2, M. Yamakawa2, H. Yamashita1.
1
Opthalmology & Vis Sciences, Yamagata Univ
Faculty of Med, Yamagata, Japan; 2Department
of Diagnostic Pathology, Yamagata University
Faculty of Medicine, Yamagata, Japan; 3Department
of health and nutrition, Yamagata Prefectural
Yonezawa Women’s Junior College, Yamagata,
Japan *CR
3669 — 3:45 Corneal Endothelial Cell Changes
In Children with Uveitis and Ahmed Valves.
Mathew S. Margolis, G. N. Holland, J. Caprioli,
F. Yu, S. K. Law, J. A. Giaconi, A. J. Aldave.
Ophthalmology, Jules Stein Eye Institute, UCLA,
Los Angeles, CA *CR
3670 — 4:00 The Comparison of Podoplanin
Expression Between Choroidal and
Conjunctival Melanoma. Kazuichi Maruyama1,
Y. Usui2, S. Ueda2, Y. Maruyama3, H. Goto2, T.
Nakazawa1. 1Ophthalmology, Tohoku University
Graduate School of Medicine, Sendai, Japan;
2
Ophthalmology, Tokyo Medical University, Tokyo,
Japan; 3Ophthalmology, Kyoto Prefectural Univ of
Med, Kyoto, Japan *CR
3671 — 4:15 Therapeutic use of chimeric
bacteriophage (phage) endolysins in
staphylococcal endophthalmitis. Pawan
Kumar Singh1, D. M. Donovan3, A. Kumar1, 2.
1
Ophthalmology, Kresge Eye Institute, Wayne State
University, Detroit, MI; 2Anatomy & Cell Biology,
Wayne State University, Detroit, MI; 3Animal
Biosciences and Biotechnology, Beltsville Agricult.
Res. Center, ARS, USDA, Beltsville, MD
608
Tuesday, May 07, 2013 2:45 PM-4:30 PM
Anatomy/Pathology
365 Myopia: Molecular/Genetic
Mechanisms
Moderators: Debora L. Nickla and
Timothy G. Murray
3672 — 2:45 Association studies of EGR-1,
PCDHB9, NARF, OGDH and SELENBP1 with
myopia and myopia sub phenotypes reveals
a novel association of OGDH with corneal
curvature. Paul N. Baird, M. Schache. Ctr for
Eye Res-Australia, University of Melbourne, East
Melbourne, VIC, Australia
3673 — 3:00 Evaluation of MicroRNA
Expression Profiles for Form-Deprivation
Myopia in Mouse. Xiaoyan Luo1, 2, T. V.
Tkatchenko3, A. V. Tkatchenko3, 4, R. Metlapally5,
P. Gonzalez1, T. L. Young1, 2. 1Department of
Ophthalmology, Duke University, Durham, NC;
2
Duke Center for Human Genetics, Duke University
Medical Center, Durham, NC; 3Department of
Anatomy & Cell Biology, Wayne State University,
Detroit, MI; 4Department of Ophthalmology, Wayne
State University, Detroit, MI; 5School of Optometry,
University of California at Berkeley, Berkeley, CA
*CR
3674 — 3:15 Gene Expression Studies
implicate Physiological Stress in Form
Deprivation Myopia. Sheila G. Crewther, L.
Giummarra, M. J. Murphy. Psychological Science,
La Trobe University, Melbourne, VIC, Australia
3675 — 3:30 Bidirectional Gene Expression
in Tree Shrew Choroid during Lens-Induced
Myopia and Recovery. Li He, M. R. Frost, J. T.
Siegwart, T. T. Norton. Vision Sciences, Univ of
Alabama at Birmingham, Birmingham, AL
3676 — 3:45 Regional variations in corneal and
scleral mRNA expressions of MMP2, TIMP2,
TGFβ2 in highly myopic-astigmatic chicks. CheaSu Kee1, Y. Xi1, C. Chu1, S. Yip2, J. A. Summers
Rada3. 1School of Optometry, The Hong Kong
Polytechnic University, Kowloon, Hong Kong;
2
Department of Health Technology and Informatics,
The Hong Kong Polytechnic University, Kowloon,
Hong Kong; 3Department of Cell Biology, The
University of Oklahoma, Oklahoma City, OK
3677 — 4:00 Atropine Prevents Myopia via
a Nitric Oxide-Mediated Relay. Brittany Carr1,
N. M. Nathanson3, W. K. Stell2. 1Neuroscience,
University of Calgary, Calgary, AB, Canada; 2Cell
Biology & Anatomy, Surgery, Neuroscience, and
Hotchkiss Brain Institute, University of Calgary,
Calgary, AB, Canada; 3Pharmacology, University of
Washington, Seattle, WA
3678 — 4:15 Reciprocal activities of dopamine
D1 and D2 receptors on the form deprivation
myopia in pigmented guinea pigs. Xiangtian
Zhou, S. Zhang, H. Ying, J. Qu. School of
Ophthalmology and Optometry, Wenzhou Medical
College, Wenzhou, Zhejiang, China
609
Tuesday, May 07, 2013 2:45 PM-4:30 PM
Lens
366 Lens Proteins/Transport
Moderators: Vasanth Rao and
Judith A. West-Mays
3679 — 2:45 Comparative proteomic analysis
identifies changes in abundance of specific lens
proteins by an alphaA-crystallin mutation
in vivo. Usha P. Andley1, J. P. Malone3, R. R.
Townsend2, 3. 1Ophthalmology and Visual Sciences,
Washington Univ Sch of Med, St Louis, MO;
2
Medicine, Washington Univ Sch of Med, St. Louis,
MO; 3Cell Biol and Physiol, Washington Univ Sch
of Med, St. Louis, MO
3680 — 3:00 Connexin50 mutation D47A
impairs lens fiber cell differentiation and
organelle degradation as well as causing
cataracts. Eric C. Beyer1, P. J. Minogue1, H. Yu1,
R. Schroeder1, J. Snabb1, R. K. Zoltoski2, V. M.
Berthoud1. 1Pediatrics, University of Chicago,
Chicago, IL; 2Illinois College of Optometry,
Chicago, IL
3681 — 3:15 P2X channels contribute to a nonselective cation (NSC) conductance in isolated
lens fiber cells that is activated by cell shrinkage.
Paul J. Donaldson1, 2, S. J. Gunning1. 1Optometry
and Vision Science, University of Auckland,
Auckland, New Zealand; 2School of Medical
Sciences, University of Auckland, Auckland, New
Zealand
3682 — 3:30 Effect of external divalent cations
on Cx46 hemichannel activity. Lisa Ebihara, A.
Rounis, J. Tong. Physiology, Rosalind Franklin Sch
of Med, North Chicago, IL
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
248
Tuesday – Papers/Minisymposium – 3683 – 3701
3683 — 3:45 Identification of the substrate and
characterization of transport properties for the
cataract associated monocarboxylate transporter
MCT12. Barbara Kloeckener-Gruissem1, 9, N.
J. Philp2, J. Abplanalp1, 9, S. M. Camargo6, 8, D.
F. Schorderet3, 4, F. L. Munier5, J. Neidhardt1, F.
Verrey6, 8, E. Laczko7, W. Berger1, 8. 1Institute of
Medical Molecular Genetics, University of Zurich,
Schwerzenbach, Switzerland; 2Department of
Pathology, Anatomy and Cell Biology, Thomas
Jefferson University, Philadelphia, PA; 3Institute
for Research in Ophthalmology, University of
Lausanne, Lausanne, Switzerland; 4Faculty of
Life Sciences, École polytechnique fédérale de
Lausanne, Lausanne, Switzerland; 5Jules-Gonin
Eye Hospital, University of Lausanne, Lausanne,
Switzerland; 6Institute of Physiology, University of
Zurich, Zurich, Switzerland; 7Functional Genomics
Center Zurich, University of Zurich /ETHZ, Zurich,
Switzerland; 8Zurich Center for Integrative Human
Physiology (ZIHP), University of Zurich, Zurich,
Switzerland; 9Department of Biology, ETHZ,
Zurich, Switzerland
3685 — 4:15 Deletion and mutation of βA3/A1crystallin produce distinct ocular phenotypes. J
S. Zigler1, L. Dong2, E. F. Wawrousek2, S. L. Hose1,
L. Gu3, G. Xu3, D. Sinha1. 1Smith Bldg, Rm M037,
Johns Hopkins Univ/Wilmer Eye Inst, Baltimore,
MD; 2National Eye Institute, Bethesda, MD;
3
School of Medicine, Tongji University, Shanghai,
China
3689 — 3:30 Prevention of Caspase Activation
and Apoptotic Death of R28 Retinal Neuronal
Cells by IGF-1 Corresponds with AKTDependent Inhibition of FOXO1 Function.
Thomas W. Gardner, L. Gong, S. He, E. Arnold, P.
E. Fort, S. F. Abcouwer. Ophthalmology and Visual
Sciences, Kellogg Eye Ctr Univ of Michigan, Ann
Arbor, MI *CR
3690 — 3:45 Release of pro- and antiangiogenic factors from Müller glia cells in
response to hyperoxia. Silke Becker, P. B. Cottrill,
R. Longbottom, K. Eastlake, M. F. Jones, H.
Jayaram, G. Limb. ORBIT, University College
London, London, United Kingdom
3691 — 4:00 Interleukin-10, a Potent Counter
Regulator of the Hyperglycemia-Induced
Pro-Inflammatory Interleukin-1 Signaling in
Müller Cells. Prathiba Jayaguru, M. Joaquin, S.
Mohr. Physiology, Michigan State University, East
Lansing, MI
3692 — 4:15 MicroRNA-15a Is Involved In
Ceramide Inflammatory Pathways by Targeting
the Acid Sphingomyelinase (ASM) In Diabetic
retina. Qi Wang1, S. N. Bozack1, M. B. Grant2, M. E.
Boulton3, W. J. Esselman4, J. V. Busik1. 1Physiology,
Michigan State University, East Lansing, MI;
2
Pharmacology and Therapeutics, University
of Florida, Gainesville, FL; 3Anatomy and Cell
Biology, University of Florida, Gainesville, FL;
4
Microbiology and Molecular Genetics, Michigan
State University, East Lansing, MI
615-617
Tuesday, May 07, 2013 2:45 PM-4:30 PM
Clinical/Epidemiologic Research / Genetics
611-614
Tuesday, May 07, 2013 2:45 PM-4:30 PM
Retinal Cell Biology
367 Diabetic Retinopathy: Cell Biology
Moderators: Thomas W. Gardner and Julia V.
Busik
3686 — 2:45 Why does diabetes result in
impaired mitochondria DNA biogenesis in
the retina? Julia M. Santos, R. A. Kowluru.
Ophthalmology, Kresge Eye- Wayne State Univ,
Detroit, MI
3687 — 3:00 Retinal NADPH oxidase-2 (Nox2) activation precedes mitochondrial damage
in the development of diabetic retinopathy.
Anjan Kowluru1, R. A. Kowluru2, J. M. Santos2.
1
Pharmaceutical Sciences, Wayne State University,
Detroit, MI; 2Ophthalmology, Wayne State
University, Detroit, MI
368 Epigenetics: Genes and
Environment - Minisymposium
The emerging field of epigenetics provides the basis
for understanding how the genome and environment
interact to influence disease processes. This
symposium will provide an overview of current
methodological and technological developments
and describe some ongoing work in glaucoma and
AMD.
Moderators: Astrid E. Fletcher, Alex W. Hewitt
and John H. Fingert
— 2:45 Introduction
3693 — 2:50 Opening Our Eyes to Epigenetics.
Alex W. Hewitt. Department of Ophthalmology,
Centre for Eye Research Australia, Surrey Hills,
VIC, Australia
3694 — 3:10 Epigenetic Changes Associated
with Neuronal Cell Death. Robert W. Nickells.
Ophthalmology & Visual Science, Univ of
Wisconsin-Madison, Madison, WI
3695 — 3:30 Genes and Nutrition, How Do
They (Counter) Interact in the Development of
AMD? Caroline C. Klaver. Ophthalmology and
Epidemiology, Erasmus Medical Center, Rotterdam,
Netherlands *CR
3696 — 3:50 Nature and Nurture and Macular
Degeneration: Insights from Twin Studies.
Johanna M. Seddon. Ophthalmology, Tufts Univ
School of Medicine, Boston, MA *CR
3697 — 4:10 Aging and Epigenetics: How Do
They Relate to AMD? Leonard M. Hjelmeland.
Ophthalmology, Univ of California-Davis, Davis,
CA *CR
618-620
Tuesday, May 07, 2013 2:45 PM-4:30 PM
Physiology/Pharmacology
369 Pharmacological Targets for Eye
Disease: Present and Future
Moderators: Craig E. Crosson, Filippo Drago and
Carol B. Toris
3698 — 2:45 Localization and Activity of
Histone Deacetylases in the Retina. Oday
Alsarraf, J. Fan, C. Chou, C. E. Crosson.
Ophthalmology - Storm Eye Institute, Medical
University of South Carolina, Charleston, SC *CR
3699 — 3:00 Sigma-1 Receptor Stimulation
Protects Purified RGCs from Ischemic Insult
through the Phosphorylation of Extracellular
Signal Regulated Kinase 1/2. Brett H. Mueller1, 2,
Y. H. Park1, 2, H. Ma1, 2, T. Yorio1, 2. 1Pharmacology
& Neuroscience, Univ of North Texas Hlth Sci
Ctr, Fort Worth, TX; 2North Texas Eye Research
Institute, University of North Texas Health Science
Center, Fort Worth, TX
3700 — 3:15 NO Activates Src Family
Kinase and Inhibits Na,K-ATPase Activity in
Nonpigmented Ciliary Epithelium. Mohammad
Shahidullah, A. Mandal, G. Wei, N. A. Delamere.
Physiology, Univ of Arizona, College of Medicine,
Tucson, AZ
3701 — 3:30 Mechanisms of retinal cell
swelling, volume sensing and mechanical
excitotoxicity. Daniel A. Ryskamp1, 2, A. O.
Jo2, A. Frye-Gordon2, S. Chauhan2, T. Molnár2,
D. Krizaj1, 2. 1Interdepartmental Program in
Neuroscience, University of Utah School of
Medicine, Salt Lake City, UT; 2Department of
Ophthalmology and Visual Sciences, Moran Eye
Institute, University of Utah School of Medicine,
Salt Lake City, UT
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
249
Tuesday Papers
Minisymposium
2:45 pm – 4:30 pm
3684 — 4:00 L-Type Calcium Channels Play
a Critical Role in Maintaining Lens Water
Permeability and Transparency by Influencing
Aquaporin-0 Phosphorylation and Connexin-50
Expression. Rupalatha Maddala1, T. Nagendran1,
K. L. Schey2, V. Rao3. 1Ophthalmology, Duke
University Medical Center, Durham, NC;
2
Biochemistry, Vanderbilt University School of
Medicine, Nashville, TN; 3Ophthalmology &
Pharmacology, Duke University Medical Center,
Durham, NC
3688 — 3:15 Role of Autophagy in Diabetic
Retinopathy and Metabolic Stress. Edith
Arnold, P. E. Fort, S. F. Abcouwer, T. W. Gardner.
Ophthalmology and Visual Science, University of
Michigan, Ann Arbor, MI *CR
3702 – 3723 – Tuesday – Papers/Minisymposium
3702 — 3:45 Comprehensive Analysis of
Prostanoid Receptor Antagonists Effects on
Intraocular Pressure in Ocular Hypertensive
Monkeys. Carol B. Toris1, T. L. Rudebush1, S.
Wenthur1, D. F. Woodward2. 1Ophthalmology, Univ
of Nebraska Medical Ctr, Omaha, NE; 2Biological
Sciences, Allergan, Inc., Irvine, CA *CR
3703 — 4:00 Endothelium Independence
of ROCK-Mediated Retinal Arteriolar
Constriction. Luke B. Potts1, Y. Ren2, L. Kuo1, 2,
T. W. Hein2. 1SBTM, Texas A&M Health Science
Ctr, Temple, TX; 2Scott and White Eye Institute,
Temple, TX
3704 — 4:15 Fenofibric Acid Protects Rod
Precursor and Müller Cells from Oxidative
Stress and Hypoxia in a PPAR-alpha-Dependent
Mechanism. Elizabeth P. Moran1, 2, L. Ding1, 3,
Y. Chen1, 3, Y. Hu1, 3, Y. Takahashi1, 3, J. Ma1, 3.
1
Endocrinology, University of Oklahoma Health
Sciences Ctr, Oklahoma City, OK; 2Cll Biology,
University of Oklahoma Health Sciences Center,
Oklahoma City, OK; 3Physiology, University of
Oklahoma Health Sciences Ctr, Oklahoma City, OK
TCC LL 4/5
Tuesday, May 07, 2013 2:45 PM-4:30 PM
Visual Psychophysics / Physiological Optics
Tuesday Papers/
Minisymposium
2:45 pm – 4:30 pm
370 Color Vision
Moderators: Jan J. Kremers, Rigmor C. Baraas
and Steven L. Buck
3705 — 2:45 A psychophysical approach to
spectral classification of single cones in vivo.
William S. Tuten1, W. M. Harmening2, L. C.
Sincich3, A. Roorda2. 1Vision Science, University
of California, Berkeley, Berkeley, CA; 2School
of Optometry, University of California, Berkeley,
Berkeley, CA; 3Vision Sciences, University of
Alabama at Birmingham, Birmingham, AL *CR
3706 — 3:00 S-cone Electroretinograms in
Old and New World Primates Recorded Using
Two Methods. James A. Kuchenbecker, S. H.
Greenwald, M. Neitz, J. Neitz. Ophthalmology,
University of Washington, Seattle, WA *CR
3707 — 3:15 Age-related decline in chromaticspatial sensitivity. Elise W. Dees1, 2, S. J. Gilson1,
R. C. Baraas1. 1Optometry & Visual Science,
Buskerud University College, Kongsberg, Norway;
2
Mathematical Sciences & Technology, Norwegian
University of Life Sciences, Ås, Norway
3708 — 3:30 Contrast Sensitivity (CS): Color
CS is Decreased More than Luminance CS at
Low Light Levels. Jeff C. Rabin1, M. Castro1,
D. Ewing1, H. George1, P. Lau1, S. Leon1, A.
Yoder1, J. Gooch2, S. Wright2. 1Optometry, UIW
Rosenberg School of Optometry, San Antonio,
TX; 2Ophthalmology, USAF School Aerospace
Medicine, Dayton, OH
3709 — 3:45 Rod and cone inputs differ
to bright and dark colors. Steven L. Buck, V.
Hadyanto, W. Short, M. Tang, J. Vincent, L. Wilson.
Dept of Psychology, University of Washington,
Seattle, WA
3716 — 4:00 Laser thermal load induces
characteristic changes in the corneal surface
including asphericity. Sean J. McCafferty, J. T.
Schwiegerling. Arizona Eye Consultants, Tucson,
AZ *CR
3710 — 4:00 Cone signals feeding into
luminance can exhibit large phase delays
and sign reversals: the effect of an inhibitory
surround network? Andrew Stockman. Department
of Visual Neuroscience, UCL Institute of
Ophthalmology, London, United Kingdom
3717 — 4:15 Effect of small aperture intracorneal inlay on peripheral kinetic visual fields.
Eric T. Brooker, A. S. Vilupuru, G. O. Waring.
AcuFocus, Irvine, CA *CR
TCC 304
Tuesday, May 07, 2013 2:45 PM-4:30 PM
TCC 303
Tuesday, May 07, 2013 2:45 PM-4:30 PM
Cornea
371 Refractive Surgery
Moderators: Tae-im Kim and Pedram Hamrah
3711 — 2:45 In Vivo Confocal Microscopy
Demonstrates a Profound Increase in Immune
Dendritic Cells and Decrease in Corneal Nerves
in Patients with Post-Refractive Surgery
Keratoneuralgia. Yureeda Qazi1, S. Aggarwal1, B.
M. Cavalcanti1, A. Cruzat1, L. J. Wu2, P. Rosenthal2,
P. Hamrah1, 3. 1Ophthalmology, Massachusetts Eye
and Ear Infirmary, Boston, MA; 2Boston Foundation
for Sight, Needham, MA; 3Immune Disease
Institute, Harvard Medical School, Boston, MA
3712 — 3:00 Small Incision Lenticule
Extraction (SMILE) procedure for the correction
of myopia and myopic astigmatism: What we
have learned after 120 eyes in 1 year. Arturo J.
Ramirez-Miranda, A. Navas, A. De La Mota, T.
Ramirez-Luquín, E. O. Graue-Hernández. Cornea
and Refractive Surgery, Instituto de Oftalmologia
“Conde de Valenciana”, Mexico City, Mexico *CR
Visual Neuroscience
372 Into the Blue: New Developments
in S-cone Visual Channels Minisymposium
Short-wavelength-sensitive cones and the retinal
circuits that they supply are a highly conserved
feature of the mammalian visual system. There
have been a number of interesting developments
related to S-cone systems in the last several years at
several levels, ranging from the cones themselves,
through specific bipolar-cell types to distinctive
types of amacrine and ganglion cells. Blue-yellow
opponent ganglion cells are more diverse than once
appreciated, and appear to maintain segregated
signaling channels through the koniocellular layers
of the dLGN. This minisymposium will survey new
understanding and residual controversy in this area
of retinal neurobiology.
Moderators: Wei Li and Jay Neitz
3718 — 2:45 Introduction. Jay Neitz.
Ophthalmology, Univ of Washington, Medical
School, Seattle, WA *CR
3713 — 3:15 Combined Small Incision
Lenticule Extraction and Intrastromal Crosslinking in Forme fruste Keratoconus. Karla P.
Lopez, G. L. Pagano, A. Navas, T. Ramirez-Luquín,
A. J. Ramirez-Miranda, E. O. Graue-Hernández.
Cornea and Refractive Surgery, Instituto de
Oftalmologia “Conde de Valenciana”, Mexico City,
Mexico *CR
3719 — 2:50 Anatomy of S-cones and S-cone
Bipolar Cells. Silke Haverkamp. Max Planck
Institute for Brain Research, Frankfurt/Main,
Germany
3714 — 3:30 Determination of the excimer
laser ablation rate in the porcine cornea after
corneal collagen cross-linking (CXL). Olivier
Richoz1, S. Arba Mosquera2, T. Magnago2, F.
Hafezi1, 3. 1Ophthalmology, Geneva University
Hospital, Geneva, Switzerland; 2R&D, Eye
Tech Solutions, Kleinostheim, Germany;
3
Ophthalmology, Doheny Eye Institute, Keck
School of Medicine, Los Angeles, CA *CR
3721 — 3:30 Synaptic Circuits Underlying
Blue-Yellow Chromatic Opponency in RGCs.
Joanna Crook. Univ. of Washington, Seattle,
Seattle, WA
3715 — 3:45 Enhanced Screening for Ectasia
Susceptibility among LASIK Candidates.
Renato Ambrosio Jr1, 2, I. C. Ramos1, M. L.
Plamper1, A. C. Canedo1, A. Luz1, 2, R. Correa1, F. P.
Guerrra1. 1Ophthalmology, Rio de Janeiro Cornel
Tomography and Biomechanics Study Group,
Rio de Janeiro, Brazil; 2Ophthalmology, Federal
University of Sao Paulo, Sao Paulo, Brazil *CR
3723 — 4:10 Cortical Representations of
S-Cone Signals. Stephen D. Van Hooser. Biology,
Brandeis University, Waltham, MA
3720 — 3:10 Amacrine-Cell Substrates of
Blue-Off Responses. Wei Li. Unit of Retinal
Neurophysiol, National Eye Institute, NIH,
Bethesda, MD
3722 — 3:50 S Cone Signals In Subcortical
Pathways: Segregation and Specificity. Paul R.
Martin. Save Sight Institute, University of Sydney,
Sydney, NSW, Australia
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
250
Tuesday – Posters – 3724 – 3744
Exhibit Hall A0063-A0094
Tuesday, May 07, 2013 2:45 PM-4:30 PM
Retinal Cell Biology
373 Retinal Development I:
Photoreceptors, Retina and RPE
Moderator: Ann C. Morris
3724 — A0063 The role of Cx3cr1 signalling
in photoreceptor development. Andrew I.
Jobling, K. A. Vessey, M. Waugh, J. A. Phipps, E. L.
Fletcher. Anatomy & Neuroscience, University of
Melbourne, Melbourne, VIC, Australia *CR
3725 — A0064 Inactivation of the miR183/96/182 Cluster Results In Photoreceptor
Postnatal Developmental Arrest and Synaptic
Defects, Leading to Retinal Dysfunction and
Degeneration. Shunbin Xu1, 2, S. Lumayag1, 2, N.
J. Corbett2, K. J. Wahlin3, S. B. Turturro1, 2, P.
Larsen4, D. Valle5, D. J. Zack3, D. A. Nicholson2,
C. Cowan1, 2. 1Pharmacology, and Ophthalmology,
Rush University Medical Center, Chicago, IL;
2
Neurological Science, Rush University Medical
Center, Chicago, IL; 3Wilmer Eye Institute, Johns
Hopkins University, School of Medicine, Baltimore,
MD; 4Biosciences Division, Argonne National
Lab, Lemont, IL; 5McKusick-Nathans Institute
of Genetic Medicine, Johns Hopkins University,
School of Medicine, Baltimore, MD *CR
3727 — A0066 Swine PAX6-, ISL1+, RCVRN+
Cone Progenitors and NRL+ Rod progenitors
Arise Sequentially From Distinct Retinal
Stem Cell Populations and Display Transient,
Nonoverlapping Regenerative Potential After
Retinal Transplantation. Wei Wang1, Z. Liang1, 5,
S. Lee1, 2, Y. Liu1, 4, J. P. Fernandez de Castro1, D.
Emery1, E. Vukmanic1, H. J. Kaplan1, D. C. Dean1,
3 1
. Ophthalmology & Visual Sciences, University
of Louisville, Louisville, KY; 2Department of
Ophthalmology, Kosin University, Kosin, Republic
of Korea; 3James Graham Brown Cancer Center,
University of Louisville, Louisville, KY; 4Birth
Defects Center, University of Louisville, Louisville,
KY; 5Department of Ophthalmology, Central South
University, Changsha, China
3730 — A0069 Characterizing cone pedicle
connectivity in zebrafish. W Ted Allison.
1
Biological Sciences, U Alberta, Edmonton, AB,
Canada; 2Medical Genetics, U Alberta, Edmonton,
AB, Canada
3731 — A0070 Sterile alpha motif containing
7 (Samd7) is a novel Crx- and Nrl-regulated
transcriptional repressor in the retina. Alexander
Aslanidis, M. Karlstetter, Y. Walczak, A. Lückoff, E.
Scheiffert, N. Bremicker, T. Langmann. Department
of Ophthalmology, University of Cologne, Cologne,
Germany
3732 — A0071 Chromatin and epigenetic
changes in Rhodopsin promoter and gene
during retina maturation. Evgenya Popova1, 2, C.
J. Barnstable1, 2. 1Neural & Behavioral Sciences,
College of Medicine, Penn State Univ, Hershey, PA;
2
Hershey Eye Center, College of Medicine, Penn
State University, Hershey, PA
3733 — A0072 DeltaC and DeltaD Signaling
Contributes to the Proper Development of
Photoreceptor Subtypes in Zebrafish. Sylvia I.
Bonilla, Y. Leung. Biological Sciences, Purdue
University, West Lafayette, IN
3734 — A0073 The transcription factor six7
regulates rod number during zebrafish retinal
development. Mailin Sotolongo-Lopez1, K. AlvarezDelfin2, 1, J. M. Fadool1. 1Florida State University,
Tallahassee, FL; 2University Of Miami, Miami, FL
3735 — A0074 Characterization of
protocadherin-21 localization in rod and cone
photoreceptors of several species. Orson L.
Moritz, L. Yang. Ophthalmology & Visual Sciences,
University of British Columbia, Vancouver, BC,
Canada
3736 — A0075 A conserved OTX-NRL network
intersects with the Hippo signaling pathway to
control robust photoreceptor fate decisions in
the Drosophila eye. Tiffany Cook, B. Xie. Pediatric
Ophthal/Dev Biol, Cincinnati Children’s Hosp Med
Ctr, Cincinnati, OH
3728 — A0067 Co-expression of RNAs
Corresponding to Multiple Retinal Cell Markers
in Human Cone Precursors. Hardeep P. Singh1,
X. L. Xu2, D. Cobrinik1. 1Pediatrics, Memorial
Sloan-Kettering Cancer Center, New York, NY;
2
Pathology, Memorial Sloan-Kettering Cancer
Center, New York, NY *CR
3737 — A0076 Functional analysis of (pro)
renin receptor in mouse retinal development.
Atsuhiro Kanda1, K. Noda1, K. Yuki2, Y. Ozawa2, T.
Furukawa3, A. Ichihara4, S. Ishida1. 1Laboratory
of Ocular Cell Biology and Visual Science,
Department of Ophthalmology, Hokkaido
University Graduate School of Medicine,
Sapporo, Japan; 2Department of Ophthalmology,
Keio University School of Medicine, Tokyo,
Japan; 3Molecular and Developmental Biology,
Institute for Protein Research, Osaka University
& JST, CREST, Suita, Japan; 4Department of
Endocrinology and Hypertension, Tokyo Women’s
Medical University, Tokyo, Japan *CR
3738 — A0077 COPI Coated Vesicles and
PRA1 Co-localize and are Mis-localized in
Differentiating rd1 Photoreceptors. Ameair
Abu Irqeba, J. M. Ogilvie. Biology, Saint Louis
University, Saint Louis, MO
3739 — A0078 Identification and functional
analysis of genes that expressed in late
retinal progenitor cells. Yujin Mochizuki1, 4, S.
Watanabe2, A. Mizota3, N. Ebihara1, A. Murakami4.
1
Ophthalmology, Juntendo University Urayasu
Hospital, Chiba, Japan; 2Department of Molecular
and Developmental Biology, Institute of Medical
Science, Tokyo University, Tokyo, Japan;
3
Ophthalmology, Teikyo University, Tokyo, Japan;
4
Opthalmology, Juntendo University School of
Medicine, Tokyo, Japan *CR
3740 — A0079 The role of HGF in stabilizing
blood retinal barrier of developing retina.
JunYoung Park1, H. Song2, 3, H. Jun2, J. Kim2, J.
Kim1, 2. 1Department of Ophthalmology, Seoul
National University College of Medicine, Seoul,
Republic of Korea; 2Fight against AngiogenesisRelated Blindness (FARB) Laboratory, Seoul
National University Hospital, Seoul, Republic
of Korea; 3Biomedical Sciences, Seoul National
University College of Medicine, Seoul, Republic
of Korea
3741 — A0080 Effects of embryonic thyroid
inhibition on the development of the eye
and retina. Masha Reider, V. P. Connaughton.
Department of Biology, American University,
Washington, DC
3742 — A0081 Neuroglobin in the developing
retina. Ranjan Rajendram, H. Bradshaw, P. J.
Luthert, R. R. Ali, J. W. Bainbridge. UCL Institute
of Ophthalmology, London, United Kingdom *CR
3743 — A0082 The potential redundant roles of
AP-2α and AP-2β in the developing and postnatal
neural retina. Mizna Zaveri1, T. Williams2, J. A.
West-Mays1. 1Pathology and Molecular Medicine,
McMaster University, Hamilton, ON, Canada;
2
Departments of Craniofacial Biology and Cell and
Developmental Biology, University of Colorado,
Denver, CO
3744 — A0083 Effects of Culture Medium and
Surface Coatings on RPE Cell Differentiation.
Britta Nommiste, A. F. Carr, C. Gias, P. J. Coffey.
UCL Institute of Ophthalmology, London, United
Kingdom
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
251
Tuesday Posters
2:45 pm – 4:30 pm
3726 — A0065 Gene Interactions in Cone
Photoreceptor Differentiation: gdf6a and tbx2b.
Michele DuVal1, A. Oel1, W. Allison1, 2. 1Biological
Sciences, University of Alberta, Edmonton, AB,
Canada; 2Medical Genetics, University of Alberta,
Edmonton, AB, Canada
3729 — A0068 Retinal Photoreceptor
Development and Maturation in Preterm and
Term Infants. Lejla Vajzovic1, A. M. Dubis1,
R. O’Connell1, T. A. Moreno3, S. J. Chiu2,
S. F. Freedman1, S. Farsiu1, 2, C. A. Toth1, 2.
1
Ophthalmology, Duke University Eye Center,
Durham, NC; 2Biomedical Engineering, Duke
University, Durham, NC; 3Duke University Medical
School, Durham, NC *CR
3745 – 3767 – Tuesday – Posters
3745 — A0084 Laminin β2 and γ3 chains
regulate proliferation and differentiation of
retinal progenitor cells. Shweta Varshney1, 2, D. D.
Hunter1, 2, W. J. Brunken1, 2. 1Ophthalmology and
Cell Biology, SUNY,Downstate Medical Center,
Brooklyn, NY; 2SUNY, Eye Institute, Brooklyn, NY
3746 — A0085 Retinoic acid signaling has an
important role in development and maintenance
of the blood retinal barrier. Jing Xie1, A.
Cutler1, M. Ali1, B. Anand-Apte1, 2. 1Department
of Ophthalmic Research, Cole Eye Institute,
Cleveland Clinic, Cleveland, OH; 2Department of
Cell Biology, Cleveland Clinic Lerner College of
Medicine at CWRU, Cleveland, OH *CR
3747 — A0086 The homeobox genes Nkx5.3
and sensory organ homeobox (SOHo) are
expressed in progenitor cells in the mature
Xenopus retina. Lisa Kelly, H. M. El-Hodiri.
Center for Molecular and Human Genetics,
Nationwide Children’s Hospital Research Institute,
Columbus, OH
Tuesday Posters
2:45 pm – 4:30 pm
3748 — A0087 BMP-Smad1/5/8 Signaling is
Necessary for Development of Müller Glia. Yumi
Ueki, K. E. Cox, T. A. Reh. Biological Structure,
University of Washington, Seattle, WA
3749 — A0088 G9a Histone Methyltransferase
Activity in Retinal Progenitors is Essential
for Proper Differentiation and Survival of
Mouse Retinal Cells. Ryoji Yamazaki1, 2, K.
Katoh1, R. Sanuki1, T. Furukawa1. 1Molecular
and Development Biology, Institute for Protein
Research & JST, CREST, Suita-shi, Japan; 2Osaka
City University Graduate School of Medicine,
Abeno-ku, Japan
3750 — A0089 Involvement of Bcl2-associated
transcription factor 1 in the differentiation
of early-born retinal cells. Olivier Goureau1,
L. Picault1, A. Slembrouck1, J. A. Sahel1, 2, P. J.
McPherson3, G. Orieux1. 1Univ Pierre et Marie
Curie Paris 6, INSERM, UMR_S968; CNRS,
UMR_7210, Institut de la Vision, Paris, France;
2
INSERM-DHOS CIC 503, Centre Hospitalier
National d’Ophtalmologie des Quinze-Vingts,
Paris, France; 3Department of Pharmacology and
Toxicology, University of Toronto, Toronto, ON,
Canada *CR
3751 — A0090 Sox4 regulates ocular
morphogenesis in zebrafish. Wen Wen, L. PillaiKastoori, A. C. Morris. Biology, University of
Kentucky, Lexington, KY
3752 — A0091 The transcription factor Insm1
regulates photoreceptor differentiation and cell
cycle progression. Marie A. Forbes-Osborne, S.
G. Wilson, A. C. Morris. Department of Biology,
University of Kentucky, Lexington, KY
3753 — A0092 Sox11 is required to maintain
proper levels of Hedgehog signaling during
vertebrate ocular development. Lakshmi PillaiKastoori1, W. Wen1, S. G. Wilson1, E. Strachan2, O.
J. Lehmann2, A. C. Morris1. 1Biology, University
of Kentucky, Lexington, KY; 2Ophthalmology &
Medical Genetics, University of Alberta, Edmonton,
AB, Canada
3754 — A0093 Transcriptional regulation
by Her proteins during vertebrate retinal
development. Stephen G. Wilson, M. A. ForbesOsborne, A. C. Morris. Biology, University of
Kentucky, Lexington, KY
3755 — A0094 The function of Progranulin-a,
a microglia-specific growth factor, during
vertebrate retinal development. Caroline
Walsh1, 2, P. F. Hitchcock1, 2. 1Neuroscience Program,
University of Michigan, Ann Arbor, MI; 2Dept. of
Ophthalmology and Visual Sciences, University of
Michigan, Ann Arbor, MI, MI
Exhibit Hall A0095-A0122
Tuesday, May 07, 2013 2:45 PM-4:30 PM
Biochemistry/Molecular Biology
374 Lipids, Retinoids and
Macular Pigments
Moderators: Minghao Jin and Stephen Beatty
3756 — A0095 Analysis of Retinal
Gangliosides by Hydrophilic Interaction Liquid
Chromatography - Electrospray Ionization
Tandem Mass Spectrometry. Olivier Berdeaux1, 2,
E. A. Masson2, S. Cabaret1, 2, A. Athias3, J. Pais
De Barros3, L. Bretillon2. 1ChemoSens Platform,
INRA, Dijon, France; 2Eye & Nutrition Research
Group, INRA, Dijon, France; 3Lipidomic Analytical
Platform, University of Burgundy, Dijon, France
3757 — A0096 Circulating markers of retinal
and optic nerve lipids. Niyazi Acar1, O. Berdeaux1,
Z. He2, S. Cabaret1, P. Gain2, G. Thuret2, C. P.
Garcher3, 1, A. M. Bron3, 1, L. Bretillon1. 1INRA,
University of Burgundy, Eye & Nutrition Research
Group, Dijon, France; 2EA2521, University Jean
Monnet, Laboratory “Biology, Imaging, and
Engineering of Corneal Grafts”, Saint-Etienne,
France; 3University Hospital, Department of
Ophthalmology, Dijon, France *CR
3758 — A0097 Inflammatory cytokines
decrease cell viability and alter ganglioside
profile in retinal pigment epithelium cells
(ARPE19). Elodie A. Masson1, O. Berdeaux1, 2,
S. Cabaret1, 2, L. Bretillon1. 1Eye and Nutrition
Research Group, UMR CSGA-1324 INRA-6265
CNRS-University of Burgundy, Dijon, France;
2
ChemoSens Platform, UMR CSGA-1324 INRA6265 CNRS-University of Burgundy, Dijon, France
3759 — A0098 N-Terminal Region of Fatty
Acid Transport Protein 4 (FATP4) is Important
for Interacting with and Inhibiting RPE65
Isomerase. Songhua Li1, J. F. Green2, J. T. Jacob2,
M. Jin1, 2. 1Neuroscience, LSU Health Sciences
Center, New Orleans, LA; 2Ophthalmology, LSU
Health Sciences Center, New Orleans, LA *CR
3760 — A0099 Cloning and Characterization of
a Carboxylesterase from Bovine Retinal Pigment
Epithelium. Gennadiy P. Moiseyev1, B. X. Wu2, Y.
Takahashi5, Y. Chen1, A. T. Tsin4, R. K. Crouch3, J.
Ma1. 1Physiology, Univ of Oklahoma Hlth Sci Ctr,
Oklahoma City, OK; 2Biochemistry & Molecular
Biol, Medical Univ of South Carolina, Charleston,
SC; 3Ophthalmology, Medical Univ of South
Carolina, Charleston, SC; 4Biology, University of
Texas San Antonio, San Antonio, TX; 5MedicineEndocrinology, Univ of Oklahoma Hlth Sci Ctr,
Oklahoma City, OK *CR
3761 — A0100 The rd12 allele of Rpe65 exerts
a dominant-negative effect on vision because it
may exhibit altered intracytoplasmic trafficking.
Charles B. Wright1, M. A. Chrenek1, S. L. Foster1,
M. T. Pardue2, J. H. Boatright1, J. M. Nickerson1.
1
Ophthalmology, Emory University, Atlanta, GA;
2
Emory Univ/Ophthal, Atlanta VA Medical Center,
Decatur, GA
3762 — A0101 Mechanism for a DominantActing D477G Mutation in RPE65 Leading
to Vision Impairment. Olga Nikolaeva1, G. P.
Moiseyev1, Y. Takahashi2, J. Ma1. 1Department
of Physiology, OUHSC, Oklahoma City, OK;
2
Endocrinology, OUHSC, Oklahoma City, OK *CR
3763 — A0102 Human iPS-RPE Synthesize
and Release 11-cis Retinaldehyde from
Exogenous All-trans Retinol. Alberto Muniz1, 2,
M. L. Plamper2, J. Choi1, 2, W. A. Greene1, 2, A. J.
Johnson1, A. T. Tsin3, H. H. Wang1. 1Ocular Trauma,
United States Army Institute of Surgical Research,
Fort Sam Houston, TX; 2National Research Council,
Washington, DC; 3Biology, The University of Texas
at San Antonio, San Antonio, TX
3764 — A0103 Functional Characterization
of Peropsin in the Retinal Pigment Epithelium.
Jeremy D. Cook, R. A. Radu, H. Sun, G. H. Travis.
Ophthalmology, Jules Stein Eye Institute, UCLA
School of Medicine, Los Angeles, CA
3765 — A0104 Interphotoreceptor Retinoid
Binding Protein Protects and Delivers Retinoids
in the Cone Visual Cycle. Andrew T. Tsin1, J.
M. Mimun1, F. Gonzalez-Fernandez2. 1Biology,
University of Texas San Antonio, San Antonio, TX;
2
Veterans Affairs and SUNY Eye Institute, State
University of New York at Buffalo, Buffalo, NY
*CR
3766 — A0105 Biochemical Characterization
of Retinoid Isomerases in the RPE and Retina.
Quan Yuan, J. J. Kaylor, S. Sarfare, T. Xu, J.
Makshanoff, P. Cheng, G. H. Travis. Jules Stein Eye
Institute, UCLA, Los Angeles, CA
3767 — A0106 Isomerase 2 Activity in Primary
Müller Cells from cone-dominated Chicken
Retinas is iron-dependent. Brandi S. BettsObregon, A. S. Mendiola, A. T. Tsin. Biology, The
University of Texas at San Antonio, San Antonio,
TX
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
252
Tuesday – Posters – 3768 – 3784
3768 — A0107 Serum and Macular Response
to Lutein Supplementation: A Systematic
Review and Meta-Analysis. Estelle S. Lowry2, C.
Cardwell1, J. Woodside1, R. E. Hogg2. 1Centre for
Public Health, Queens University Belfast, Belfast,
United Kingdom; 2Centre for Vision and Vascular
Science, Queens University Belfast, Belfast, United
Kingdom *CR
3769 — A0108 Optimization of Uptake and
Bioavailability of Various Formulations of
Zeaxanthin in C57BL/6 Mice. Preejith P. Vachali,
B. Li, Z. Shen, B. M. Besch, M. W. Black, P. S.
Bernstein. Moran Eye Center, University of Utah,
Salt Lake City, UT *CR
3770 — A0109 The Effects of Maternal
Nutrition and Intrauterine Growth Restriction
on Infant Carotenoid Status. Bradley Henriksen1,
G. Chan2, R. O. Hoffman1, M. Sharifzadeh3, I.
V. Ermakov3, W. Gellermann3, X. Sheng2, P. S.
Bernstein1. 1Moran Eye Center, University of Utah
School of Medicine, Salt Lake City, UT; 2Pediatrics,
University of Utah School of Medicine, Salt Lake
City, UT; 3Physics and Astronomy, University of
Utah, Salt Lake City, UT *CR
3772 — A0111 An Investigation into Declared
vs Actual Content of Commercially Available
Food Supplements Containing the Macular
Carotenoids. Sakina Kashani1, K. A. Meagher1, S.
Beatty1, D. I. Thurnham2, A. Howard3, J. M. Nolan1.
1
Macular Pigment Research Group, Chemical and
Life Sciences, Waterford Institute of Technology,
Waterford, Ireland; 2Northern Ireland Centre for
Food and Health (NICHE), University of Ulster,
Coleraine, United Kingdom; 3Howard Foundation,
Cambridge University, Cambridge, United
Kingdom *CR
3773 — A0112 Central Retinal Enrichment
Supplementation Trials (CREST): Design and
Methodology. Kwadwo O. Akuffo, J. L. Dennison,
S. O’Regan, S. Beatty, J. M. Nolan. Chemical and
Life Sciences, Waterford Institute of Technology,
Waterford, Ireland f
3774 — A0113 Lens status and macular
pigment optical density measured by the two
wavelength autofluorescence method: the
Alienor Study. Marie B. Rougier1, C. Delcourt2, 3,
M. Delyfer1, 2, M. Le Goff2, 3, F. Malet1, J.
Dartigues2, 3, J. Colin1, 3, J. Korobelnik1, 2. 1Service d
Ophtalmologie, CHU-Bordeaux Univ de Bordeaux,
Bordeaux, France; 2INSERM U897, Bordeaux,
France; 3Université Bordeaux2, Bordeaux, France
*CR
3776 — A0115 Concordance of macular
pigment measurements using heterochromatic
flicker photometry, autofluorescence, and
reflectometry. Jessica L. Dennison, J. Stack, S.
Beatty, J. M. Nolan. Chemical & Life Sciences,
Waterford Institute of Technology, Waterford,
Ireland
3777 — A0116 A Comparison of the
MacuScope and QuantifEye Macular Pigment
Densitometers in Two Distinct Population Types.
Robert J. Donati, E. Wyles. Illinois College of
Optometry, Chicago, IL
3778 — A0117 Evaluation of a novel
instrument for simultaneous measurement
of macular pigment and lens optical density,
and lens equivalent age. Richard A. Bone1,
A. Mukherjee1, J. B. Morris2. 1Physics, Florida
International University, Miami, FL; 2Morris Eye
Group, Encinitas/Vista, CA *CR
3779 — A0118 Enhancement of Macular
Pigment Levels in Diabetics with Early
Retinopathy through Supplementation
Demonstrated Using Two Objective Techniques.
Nicole K. Scripsema1, 3, N. Shah2, P. Garcia1, D.
Warrow1, K. Tobias2, G. Landa1, 3, R. B. Rosen1, 3.
1
The Retina Center, The New York Eye and Ear
Infirmary, New York, NY; 2The Einhorn Clinical
Research Center, The New York Eye and Ear
Infirmary, New York, NY; 3Ophthalmology, New
York Medical College, Valhalla, NY *CR, f
3780 — A0119 A randomized trial of
supplementation with lutein, zeaxanthin,
omega 3 fatty acids and antioxidants for
increasing macular pigment optical density in
high-risk subjects: the LIMPIA Study. JeanFrancois Korobelnik1, 2, M. Delyfer1, 2, M. B.
Rougier1, H. Savel4, G. Chêne4, C. Delcourt2, 3, C.
P. Garcher5. 1Service d’Ophtalmologie, Hopital
Pellegrin, Bordeaux, France; 2Univ. Bordeaux,
ISPED, Centre INSERM U897-EpidemiologieBiostatistique, Bordeaux, France; 3INSERM,
ISPED, Centre INSERM U897-EpidemiologieBiostatistique, Bordeaux, France; 4Unité de
Soutien Méthodologique à la Recherche (USMR),
CHU de Bordeaux, Bordeaux, France; 5Service
d’Ophtalmologie, CHU de Dijon, Dijon, France
*CR, f
3781 — A0120 Comparison of macular pigment
optical density measured by autofluorescence
and reflectometry: the LIMPIA Study. Catherine
P. Garcher1, 2, M. Delyfer3, 4, M. B. Rougier3, H.
Savel6, G. Chêne6, C. Delcourt5, 6, J. Korobelnik3, 4.
1
Ophthalmology, University Hospital, Dijon,
France; 2Eye and Nutrition Research Group,
UMR CSGA-1324 INRA-6265 CNRS-Université
de Bourgogne-AgroSup, Dijon, Dijon, France;
3
Ophthalmology, CHU Bordeaux, Bordeaux,
France; 4Univ. Bordeaux, ISPED, Centre INSERM
U897-Epidemiologie-Biostatistique, Bordeaux,
France; 5INSERM, ISPED, Centre INSERM U897Epidemiologie-Biostatistique, Bordeaux, France;
6
Unité de soutien méthodologique à la recherche
clinique et épidémiologie (USMR), Pôle de Santé
Publique, CHU Bordeaux, Bordeaux, France *CR,
f
3782 — A0121 Serial Assessment of Macular
Pigment Distribution Profiles Obtained
Using Minimum Motion Photometry: 10 to
15-Year Follow-Up. Jack D. Moreland1, A.
G. Robson2, 3, D. Pauleikhoff4, F. J. van Kuijk5.
1
Life Sciences, Keele University, Keele, United
Kingdom; 2Electrophysiology, Moorfields Eye
Hospital, London, United Kingdom; 3Institute
of Ophthalmology, University College London,
London, United Kingdom; 4St Franziskus Hospital,
Muenster, Germany; 5Life Sciences, Keele
University, Keele, United Kingdom
3783 — A0122 Effects of Zeaxanthin on
Constitutive and TPA-Induced Secretion of
VEGF by Human Retinal Pigment Epithelial
Cells In Vitro. Dan-Ning Hu, R. B. Rosen,
A. Sclafani, S. A. McCormick. Pathology &
Ophthalmology, New York Eye & Ear Infirmary,
New York, NY *CR
Exhibit Hall B0094-B0148
Tuesday, May 07, 2013 2:45 PM-4:30 PM
Retina
375 AMD I, RE
Moderators: Edoardo Midena and
Maureen G. Maguire
3784 — B0094 Effect of Statins on Visual
Outcomes in Primary Rhegmatogenous
Retinal Detachments. Hubert Pham1, A. Venkat2,
S. Makgoeng3, A. Melamud4. 1Department of
Ophthalmology, Washington Hospital Center/
Georgetown University Hospital, Washington, DC;
2
Department of Medicine, Washington Hospital
Center, Washington, DC; 3Lombardi Comprehensive
Cancer Center, Georgetown University Medical
Center, Washington, DC; 4Retina Group of
Washington, Fairfax, VA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
253
Tuesday Posters
2:45 pm – 4:30 pm
3771 — A0110 Macular pigment optical density
response to supplemental macular carotenoids in
subjects with and without age-related macular
degeneration. Katherine A. Meagher1, D. I.
Thurnham3, S. Beatty1, A. Howard2, E. Connolly1, J.
M. Nolan1. 1Chemical and Life Sciences, Macular
Pigment Research Group, Waterford, Ireland;
2
Howard Foundation, Cambridge University,
Cambridge, United Kingdom; 3Northern Ireland
Centre for Food and Health (NICHE), University of
Ulster, Coleraine, United Kingdom *CR, f
3775 — A0114 The relationship between visual
performance and AMD severity in subjects
with early age-related macular degeneration.
John M. Nolan1, S. Sabour-Pickett1, J. Stack1,
J. Loughman2, A. Howard3, S. Beatty1. 1Macular
Pigment Research Group, Waterford Institute of
Technology, Waterford, Ireland; 2Optometry, Dublin
Institute of Technology, Dublin, Ireland; 3Howard
Foundation, Cambridge University, Cambridge,
United Kingdom f
3785 – 3808 – Tuesday – Posters
3785 — B0095 Effect of Aldehyde
Dehydrogenase 2 on Intravitreal Ranibizumab
Treatment for Polypoidal Choroidal
Vasculopathy in Japanese Patients. Eiichi Sato,
H. Kagokawa, A. Takamiya, D. Kameyama, S. Ono,
A. Yoshida. Ophthalmology, Asahikawa Medical
University, Asahikawa, Japan *CR
3793 — B0103 Analysis of 24 month data
from the HARBOR study indicates that
anti-therapeutic antibodies status had no
significant impact on the treatment response to
ranibizumab. Gary Sternberg, K. Le, E. Wakshull,
J. Rusit, J. Visich, J. A. Nau. Genentech, Inc., South
San Francisco, CA *CR, f
3786 — B0096 IRay™ treatment of Polypoidal
Choroidal Vasculopathy: a Pilot Study. Ugo
Introini, G. Triolo, G. Casalino, F. Bandello.
Ophthalmology, San Raffaele Scientific Institute,
Milan, Italy *CR, f
3794 — B0104 Visual acuity outcomes and
drug costs for different antiangiogenetic agents
in the therapy of exudative age-related macular
degeneration in a clinical setting. Alessandra
Acquistapace, A. Xhepa, R. Secondi, S. Bochicchio,
M. V. Cigada, A. Giani, G. Staurenghi. Eye Clinic
Department of Biomedical and Clinical Science
“Luigi Sacco,” Luigi Sacco Hospital, Milan, Italy
*CR
3787 — B0097 Novel Minimally-Invasive
Episcleral Brachytherapy for the Treatment of
Neovascular Age-Related Macular Degeneration
(nAMD): Results of a Twelve Month Prospective
Phase I Safety and Tolerability Evaluation.
Kamaljit S. Balaggan3, 1, R. Schindler5, L.
Joffe5, P. J. Patel2, B. Stea6, A. Tufail2, L.
Marsteller4. 1Department of Genetics, Institute
of Ophthalmology, London, United Kingdom;
2
Medical Retina Service, Moorfields Eye Hospital,
London, United Kingdom; 3Vitreoretinal Service,
Moorfields Eye Hospital, London, United Kingdom;
4
SalutarisMD, Tucson, AZ; 5Ophthalmology,
University of Arizona, Tucson, AZ; 6Radiation
Oncology, University of Arizona, Tucson, AZ *CR
Tuesday Posters
2:45 pm – 4:30 pm
3788 — B0098 Prospective Study of Pegaptanib
in the Treatment of Serous Pigment Epithel
Detachments Complicating Age- related
Macular Degeneration. Andras I. Seres1, H. Kiss2.
1
Budapest Retina Associates, Budapest, Hungary;
2
Ophthalmology, Semmelweis University, Budapest,
Hungary f
3789 — B0099 Photodynamic therapy, antivascular endothelial growth factor therapy, and
combination therapy for polypoidal choroidal
vasculopathy. Hae Min Kang, N. Lee, H. Koh.
Department of Ophthalmology, Yonsei Univ
College of Medicine, Seoul, Republic of Korea
3790 — B0100 AURORE STUDY: a french
multicenter retrospective study in wet AMD
patients treated with Verteporfin PDT plus
Ranibizumab in routine clinical practice. Franck
Rumen1, E. Latour2. 1Visiopole, Lagord, France;
2
Novartis Pharma, Rueil-Malmaison, France *CR
3791 — B0101 Intravitreal Anti-Vegf Followed
by Photodynamic Therapy Versus AntiVegf Monotherapy for Retinal Angiomatous
Proliferation. Pietro Monaco1, E. Cappello2,
M. Del Borrello1, A. Frattolillo1, L. Tollot1, M.
Vaccaro1, F. Sperti1, M. V. Cigada3. 1Ophthalmology,
San Martino Hospital, Belluno, Italy;
2
Ophthalmology, San Bassiano Hospital, Bassano
del Grappa, Italy; 3Eye Clinic, Luigi Sacco Hospital,
Milano, Italy
3792 — B0102 Long-term Results of
Combination Therapy with Half-time Reduced
Fluence Photodynamic Therapy and Intravitreal
Ranibizumab for Retinal Angiomatous
Proliferation. Hirotaka Yokouchi, M. Kitahashi, M.
Sakurai, M. Kubota-Taniai, T. Baba, S. Yamamoto.
Ophthalmology, Chiba Univ Graduate School of
Med, Chiba, Japan
3795 — B0105 Visual acuity loss at a two-year
follow-up in patients with exudative age-related
macular degeneration treated with ranibizumab
and as needed retreatment basis. Takeya
Kohno1, M. Yamamoto1, T. yoneda1, Y. Yoshida1, H.
Iwami1, M. Kaida1, M. Hirabayashi2, K. Shiraki1.
1
Ophthalmology & Visual Science, Osaka City Univ
Grad Sch of Med, Osaka, Japan; 2Ophthalmology,
Shiraniwa Hospital, Ikoma, Japan
3796 — B0106 Short-term vision changes after
switch to aflibercept therapy for age-related
macular degeneration previously treated with
other antiVEGF agents. Irene A. Barbazetto1, 2,
R. Gallego-Pinazo1, M. Engelbert1, 2. 1VitreousRetina-Macula-Consultants of NY, New York, NY;
2
Ophthalmology, New York University, New York,
NY *CR
3797 — B0107 Macular Morphology Changes
Following Intravitreal Aflibercept for TreatmentResistant Exudative AMD. Geoffrey Broadhead1, 2,
H. Li1, M. Zhu1, 2, J. Chew1, 2, W. Wijeyakumar1, A. A.
Chang1, 2. 1Sydney Retina Clinic & Day Surgery,
Sydney, NSW, Australia; 2Save Sight Institute, The
University of Sydney, Sydney, NSW, Australia *CR, f
3798 — B0108 Bevacizumab and ranibizumab
in exudative age-related macular degeneration:
Is the effectiveness conditioned by accessibility?
Jose D. Luna Pinto1, J. P. Real2, J. A. UrretsZavalia3, C. P. Juarez1, S. D. Palma2, G. E.
Granero2. 1Ophthalmology, Ctr Privado de Ojos
Romagosa-Fndtn VER, Cordoba, Argentina;
2
Pharmacy, National University of Córdoba.,
Cordoba, Argentina; 3Ophthalmology, Clinica
Universitaria Reina Fabiola, Cordoba, Argentina
3799 — B0109 The efficacy of aflibercept
in the treatment of neovascular age-related
macular degeneration previously treated with
bevacizumab or ranibizumab. Laura B. Hall,
N. Zebardast, R. A. Adelman. Ophthalmology and
Visual Science, Yale University School of Medicine,
New Haven, CT
3800 — B0110 Intravitreal Aflibercept for
Recalcitrant Neovascular AMD. Maria E.
Maldonado, D. M. Brown, C. Wykoff. Retina
Consultants of Houston, Houston, TX *CR, f
3801 — B0111 Comparison of outcomes
after switching treatment from intravitreal
bevacizumab or ranibizumab to aflibercept in
neovascular age-related macular degeneration.
Frank X. Venzara1, J. O. Mason1, J. Glover2, G.
McGwin1, 3, C. Huisingh3, D. A. Friedman1, R. M.
Feist1, M. L. Thomley1, M. A. Albert1, N. Price1.
1
Retina Consultants of Alabama, University
of Alabama Birmingham, Birmingham, AL;
2
Department of Ophthalmology, University
of Alabama Birmingham, Birmingham, AL;
3
Department of Epidemiology, University of
Alabama Birmingham, Birmingham, AL
3802 — B0112 The effect of the reflux bleb
of anti-VEGF injections on central macular
thickness. Kanishka R. Mendis, A. GalevskaDimitrovska, R. K. Thompson, B. Shadbolt.
Ophthalmology, The Canberra Hospital, Canberra,
ACT, Australia
3803 — B0113 Persistent Leakage During the
Course of Anti-VEGF Monotherapy - Etiology
and Treatment. Mark H. Nelson. North Carolina
Macular Consultants, Winston-Salem, NC
3804 — B0114 The efficacy of bimonthly
injection of ranibizumab for age-related macular
degeneration for six months. Tomoko Sawada, M.
Kakinoki, X. Wang, H. Kawamura, Y. Saishin, M.
Ohji. Ophthalmology, Shiga University of Medical
Science, Otsu, Japan *CR, f
3805 — B0115 Response and dependence to
ranibizumab therapy in AMD. Masako Kuroda1, 2,
H. Kojima1, 2, T. Kameda1, 2, M. Mandai1, 3, N.
Miyamoto1, 2, A. Nishida1, 2, Y. Kurimoto1, 2. 1Kobe
City Medical Center General Hospital, Kobe, Japan;
2
Institute of Biomedical Research and Innovation
Hospital, Kobe, Japan; 3Laboratory for Retinal
Regeneration, RIKEN Center for Developmental
Biology, Kobe, Japan *CR
3806 — B0116 Eylea Rescue Therapy in Eyes
with Proven Non-Response to Other antiVEGF Molecules. Benjamin Guidry, C. J. Chen.
University of Misssissippi, Jackson, MS
3807 — B0117 Growth of Type 1
Neovascularization Following Cessation of
Anti-Vascular Endothelial Growth Factor
Therapy as a Possible Explanation for Treatment
Resistance. Roberto Gallego-Pinazo1, 2, V. P. Shah2,
K. Freund2, 3. 1Ophthalmology, Univ & Polytechnic
Hosp La Fe, Valencia, Spain; 2Vitreous Retina
Macula Consultants of New York, New York, NY;
3
Ophthalmology, New York University School of
Medicine, New York, NY *CR
3808 — B0118 Bimonthly Ranibizumab for
Exudative Age-related Macular Degeneration.
Salomon Y. Cohen, B. Maloberti, F. Fajnkuchen,
S. Nghiem-Buffet, C. Delahaye-Mazza, T. Grenet,
G. Quentel. Centre d’Imagerie Et de Laser, Paris,
France *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
254
Tuesday – Posters – 3809 – 3831
3809 — B0119 Clinical outcomes of differing
loading phase regimes in the management of
neovascular age related macular degeneration
(nvARMD). Jignesh Patel, S. L. Woollard, N.
Hopkins, A. Zaheer, A. Salim, G. Baggiony-Taylor,
B. Sellathurai, V. Bansal. Ophthalmology, Essex
County Hospital, Colchester, United Kingdom *CR
3810 — B0120 Evaluation of the accuracy and
efficiency of an optometrist led stable AMD clinic
in a regional Age Related Macular Degeneration
(AMD) Centre. Nadeem Rob, L. North, G. Ansari,
F. Zacharaki, M. N. Chandran, G. Menon. Eye
Treatment Centre, Frimley Park Hospital, Frimley
Park, United Kingdom *CR
3811 — B0121 The Efficacy Of Biweekly
Alternating Intravitreal Bevacizumab And
Ranibizumab In Recalcitrant Choroidal
Neovascularization Secondary To Age-Related
Macular Degeneration. Radha Ram, D. S. Grewal,
S. Khan, M. K. Gill. Department of Ophthalmology,
Northwestern University, Feinberg School of
Medicine, Chicago, IL
3812 — B0122 Changing from pro re nata
treatment regimen to a treat and extend regimen
in neovascular age-related macular degeneration.
Katja B. Hatz1, 2, C. Pruente1, 2. 1VISTA Klinik,
VISTA Klinik Binningen, Binningen, Switzerland;
2
Department of Ophthalmology, Kantonsspital
Liestal, Liestal, Switzerland *CR
3814 — B0124 Patients prefer a fixed monthly
dosing regimen in anti-VEGF treatment for
neovascular age-related macular degeneration.
Katharina Droge1, D. Mueller2, A. Caramoy1,
B. Kirchhof1, S. Fauser1. 1Department of
Ophthalmology, University of Cologne, Cologne,
Germany; 2Department of Institute of Health
Economics and Clinical Epidemiology, University
of Cologne, Cologne, Germany *CR
3815 — B0125 Results of Intravitreal
Ranibizumab with a PRU Regimen in The
Treatment of Extra and Juxtafoveal Neovascular
Membranes in Age-Related Macular
Degeneration. Cinzia Mazzini, L. Finocchio, D.
Bacherini, G. Giacomelli, F. Giansanti, I. Biagini,
L. Vannozzi, G. Virgili, U. Menchini. Department
of Specialistic Surgical Sciences, Eye Clinic,
University of Florence, Florence, Italy
3816 — B0126 Effectiveness of quarterly
(Q3M) versus monthly (QM) ranibizumab
according to initial gains in visual acuity - an
analysis of 12 month data from the EXCITE
study. Victor Chong, W. M. Amoaku, J. Alsop, A.
Osborne. Oxford Eye Hospital, Oxford University
Hospitals, Oxford, United Kingdom *CR, f
3818 — B0128 Impact of the vitreous
configuration on the efficacy of quarterly, prore-nata and monthly treatment in multicenter
trials evaluating ranibizumab for neovascular
age-related macular degeneration. Sebastian M.
Waldstein1, U. Mayr-Sponer1, M. Ritter1, M. Kundi2,
C. Simader1, U. Schmidt-Erfurth1. 1Department of
Ophthalmology, Medical University of Vienna,
Vienna, Austria; 2Institute of Environmental Health,
Medical University of Vienna, Vienna, Austria *CR, f
3819 — B0129 Treatment Patterns in
Neovascular Age-Related Macular Degeneration
between 2005-2010. Eleonora M. Lad1, B. G.
Hammill2, L. G. Qualls2, F. Wang3, S. W. Cousins1,
L. H. Curtis2. 1Ophthalmology, Duke University
Eye Center, Durham, NC; 2Duke Clinical Research
Institute, Duke University School of Medicine,
Durham, NC; 3GlaxoSmithKline, King of Prussia,
PA *CR
3820 — B0130 A Three-year Follow-up of
Ranibizumab Treatment of Neovascular AMD:
Impact on Visual Outcome of Carrying Forward
the Last Acuity Observation in Drop-outs.
Christina I. Frennesson, S. G. Nilsson. Dept of
Ophthalmology, Linkoping University, Linkoping,
Sweden *CR
3821 — B0131 TWIN : Evolution of visual
acuity in patients with wet AMD diagnosed since
2010 and treated with ranibizumab, in current
practice - Comparison with LUMIERE study.
Hassiba Oubraham Mebroukine1, S. Y. Cohen2, G.
Mimoun2, E. H. Souied3, S. Quéré4, V. Schneider4.
1
Office, Montargis, France; 2Private practice, Paris,
France; 3Hospital, Creteil, France; 4Pharmaceutical
industry, Rueil Malmaison, France *CR
3822 — B0132 How bad are the long term
results under real life conditions beyond 2 years
of treatment for wet AMD with ranibizumab or
bevacizumab? Results from a 4 year follow up of
77 patients. Wolfgang F. Schrader, A. T. Bernhard,
C. Dietz, K. Sommer, E. Panidou. Ophthalmology,
Maximilians-Augenklinik, Nuernberg, Germany
*CR
3823 — B0133 Effect of anti-VEGF medication
change on central macular thickness and visual
acuity in patients with neovascular age-related
macular degeneration. John P. Campbell1, R.
M. Beardsley1, D. Choi2, C. J. Flaxel1, S. Bailey1,
A. Lauer1, T. S. Hwang1. 1Retina Division, Casey
Eye Institute, Oregon Health Sciences University,
Portland, OR; 2Public Health & Preventive
Medicine, Oregon Health & Sciences University,
Portland, OR *CR
3824 — B0134 Prospective Audit of Outcomes
of Treatment of Exudative Age-Related Macular
Degeneration: The Fight Retinal Blindness
Project. Mark C. Gillies1, D. Barthelmes2, 1.
1
Ophthalmology, University of Sydney, Sydney,
NSW, Australia; 2Ophthalmology, University
Hospital, Zurich, Switzerland *CR
3825 — B0135 United Kingdom Neovascular
AMD Database study:outcomes of over 92,000
intravitreal ranibizumab injections. Adnan Tufail.
Ophthalmology, Moorfields Eye Hospital, London,
United Kingdom *CR
3826 — B0136 Four year results of visual
outcome in Neovascular Age Related Macular
Degeneration (AMD) treated with Ranibizumab.
Anchal Kailey, M. N. Chandran, F. Zacharaki, M.
Chekuri, G. Menon. Ophthalmology, Frimley Park
Hospital NHS Foundation Trust, Frimley, United
Kingdom *CR
3827 — B0137 The effects of aflibercept
following bevacizumab or ranibizumab on visual
acuity and central macular thickness in patients
with age-related macular degeneration. Ambar
Faridi, L. Shippey, T. S. Hwang, A. Lauer, S. Bailey,
C. J. Flaxel. Ophthalmology, Casey Eye Institute,
OHSU, Portland, OR *CR
3828 — B0138 Comparison of the Relative
Efficacy of Aflibercept in the Treatment of
Neovascular Age Related Macular Degeneration
in Patients Previously Treated with Alternative
Vascular Endothelial Growth Factor Inhibitors.
Khushboo K. Agrawal1, R. Chen1, S. Ittiara1, R.
D. Patel2, S. M. Hariprasad1. 1Ophthalmology,
University of Chicago, Chicago, IL;
2
Ophthalmology, Mercy Health System, Chicago,
IL *CR
3829 — B0139 Early vs Delayed 15-Letter
Responders to Ranibizumab Treatment in Year
1 of the Phase III HARBOR Trial. Richard
Dreyer1, G. T. Kokame2, G. Stoller3, H. Shapiro4,
D. Chen5, L. Tuomi6. 1Retina Northwest, Portland,
OR; 2The Retina Center at Pali Momi, Aiea, HI;
3
Ophthalmic Consultants of Long Island, Lynbrook,
NY; 4Genentech, Inc., South San Francisco, CA;
5
Genentech, Inc., South San Francisco, CA;
6
Genentech, Inc., South San Francisco, CA *CR, f
3830 — B0140 Comparison of outcome of
anti-vascular endothelial growth factor (antiVEGF) treatment in exudative Age-related
Macular Degeneration (AMD) in the presence
and absence of Vitreomacular Adhesion (VMA).
Seena Nambiar, M. N. Chandran, N. Nair, S.
Praveen, M. Lidder, G. Menon. Ophthalmology,
Frimley Park Hospital, Surrey, United Kingdom
*CR
3831 — B0141 LUMINOUS: baseline
characteristics of the first cohort of patients
treated with ranibizumab 0.5 mg in routine
clinical practice. Christopher Brand. Royal
Hallamshire Hospital, Sheffield, United Kingdom
*CR, f
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
255
Tuesday Posters
2:45 pm – 4:30 pm
3813 — B0123 Impact of using the aflibercept
dosing regimen for wet macular degeneration
on numbers of injections and monitoring visits
over three years. Niro Narendran, R. Chavan,
S. Panneerselvam, Y. C. Yang. Ophthalmology,
Wolverhampton Eye Infirmary, Wolverhampton,
United Kingdom *CR
3817 — B0127 Age-Related Macular
Degeneration: Patient Response and Outcomes
to Aflibercept using PRN Dosing Regimen.
Gregory D. Lee, J. G. Fein, E. Reichel.
Ophthalmology, New England Eye Center, Tufts
Medical Center, Boston, MA *CR
3832 – 3853 – Tuesday – Posters
3832 — B0142 Visual outcomes of ranibizumab
treatment in fellow eyes of exudative AMD. Jamie
Chew1, 2, G. Broadhead1, 2, H. Li1, M. Zhu2, 1, A. A.
Chang1, 2. 1Sydney Retina Clinic & Day Surgery,
Sydney, NSW, Australia; 2Save Sight Institute,
University of Sydney, Sydney, NSW, Australia *CR
3833 — B0143 Short-term Effectiveness of
Intravitreal Aflibercept for Persistent Exudative
Age-Related Macular Degeneration. Andrew A.
Chang1, 2, G. Broadhead1, 2, J. Chew1, 2, M. Zhu2, H.
Li1. 1Ophthalmology, Sydney Retina Clinic Sydney
Eye Hosp, Sydney, NSW, Australia; 2Save Sight
Institute, The University of Sydney, Sydney, NSW,
Australia *CR, f
3834 — B0144 Visual And Anatomical
Outcomes Following Intravitreal Aflibercept
In Eyes With Recalcitrant Neovascular Age
Related Macular Degeneration. Dilraj S. Grewal,
D. Sarezky, R. Mirza, M. K. Gill, A. T. Lyon.
Ophthalmology, Northwestern University, Chicago,
IL
3835 — B0145 Outcomes of anti-VEGF
therapy for exudative macular degeneration
with retinal pigment epithelial tears. Joshua
Robinson, C. Luo, B. Garretson. Associated Retinal
Consultants, Royal Oak, MI
Tuesday Posters
2:45 pm – 4:30 pm
3836 — B0146 Retrospective analysis of the
real-world utilization of ranibizumab in wAMD.
Sobha Sivaprasad1, R. Tadayoni2. 1Biomedical
Research Centre, King’s College Hosp NHS
Fdtn Trust, Camberley, Surrey, United Kingdom;
2
Ophthalmology, Lariboisiere University Hospital,
Paris, France *CR, f
3837 — B0147 The efficacy of ranibizumab for
polypoidal choroidal vasculopathy in a long-term
follow-up. Keiko Azuma1, H. Takahashi2, R. Obata1,
Y. Yanagi1. 1Ophthalmology, Tokyo university,
Tokyo, Japan; 2Jichi Medical University, Tochigi,
Japan
3838 — B0148 Comparison of Intravitreal
Aflibercept with Bevacizumab and Ranibizumab
for the Treatment of Wet Age-related Macular
Degeneration. Adeel Shaikh1, 2, D. M. Miller1, 2,
M. R. Petersen1, R. E. Foster1, C. D. Riemann1,
R. A. Sisk1, 2. 1Vitreo Retinal Surgery, Cincinnati
Eye Institute, Cincinnati, OH; 2Ophthalmology,
University of Cincinnati, Cincinnati, OH *CR
Exhibit Hall B0233-B0247
Tuesday, May 07, 2013 2:45 PM-4:30 PM
Retina
376 Macular Miscellaneous
Moderator: Hua Gao
3839 — B0233 Comparison of Retinal
Atrophy after Laser, Anti-vasogenic Injections,
or Combination Therapy in the Treatment
of Branch Retinal Vein Occlusion. Quraish
Ghadiali1, 2, S. Shah1, 2, J. S. Myung1, 2, K.
Wald1, 2. 1Ophthalmology, NYU, New York, NY;
2
Ophthalmology, Manhattan Eye Ear and Throat
Hospital, New York, NY
3840 — B0234 Safety and efficacy of
Dexamethasone Intravitreal Implant in Macular
Edema due to Retinal Vein Occlusions - 1 year
follow-up. Thomas Papathomas, M. Tsagkataki,
I. Kumar, A. Kamal. Ophthalmology, Aintree
University Hospital, Liverpool, United Kingdom
3841 — B0235 Treatment of Radiation
Maculopathy with Bevacizumab versus
Alternating Bevacizumab and Intravitreal
Triamcinolone. Kelly M. Bui1, M. S. Dikopf1, J.
Hallak1, D. F. Kiernan2, C. C. Chow1, W. F. Mieler1.
1
Ophthalmology, University of Illinois at Chicago,
Chicago, IL; 2Ophthalmic Consultants of Long
Island, Lynbrook, NY *CR
3842 — B0236 Central Serous
Chorioretinopathy in Women. Donatella
Musetti, M. Nicolo, C. E. Traverso. Di.N.O.G.Mi.,
University Eye Clinic, Genova, Italy
3843 — B0237 Intravitreal Bevacizumab
for choroidal neovascularization secondary to
angioid streaks: five-year follow-up. Fedra Kort,
A. Chebil, M. Bouladi, B. Rim, E. Leila. Hedi Rais
Institute of ophthalmology, Tunis, Tunisia
3844 — B0238 The effect of BEST1 mutations
on cellular protein degradation pathways in a
BD hiPSC-RPE model. David Kuai1, M. Smith1, J.
M. Martin1, W. Shen1, A. Verhoeven1, K. Wallace1,
D. M. Gamm2, 3, R. Singh1. 1Waisman Center,
University of Wisconsin - Madison, Madison, WI;
2
Dept. of Ophthalmology and Visual Sciences,
University of Wisconsin - Madison, Madison, WI;
3
Mc Pherson Eye Research Institute, University of
Wisconsin - Madison, Madison, WI *CR
3845 — B0239 Mapping visual distortions in
macular disease. Gerard McGowan1, T. Ivanova1,
D. B. Yorston1, N. C. Strang2, V. Manahilov2.
1
Tennent Institute of Ophthalmology, Glasgow,
United Kingdom; 2Visual Science, Caledonian
University, Glasgow, United Kingdom
3846 — B0240 Sight threatening complications
in Sickle Cell Retinopathy. Gabriella De Salvo, P.
A. Keane, D. A. Sim, C. A. Egan. Medical Retina,
Moorfields Eye Hospital, London, United Kingdom
*CR
3847 — B0241 M-CSF Inhibition Prevents the
Formation of Outer Retinal Neovascularization
in a Murine Model of Macular Telangiectasia.
Edith Aguilar, T. Kurihara, P. D. Westenskow, S.
Bravo, C. M. Wittgrove, L. Paris, M. Friedlander.
Cell Biology, Scripps Research Institute, La Jolla,
CA
3848 — B0242 Surgical removal of idiopathic
epiretinal membrane with or without postmembrane peel intravitreal triamcinolone:
A comparison of anatomical and functional
outcomes. Steven A. Agemy, J. M. Kim, A. N.
Mehta, C. Kim, A. Tewari. Kresge Eye Institute,
Detroit, MI
3849 — B0243 Structured Method for
Assessing Macular Holes by OCT and
Correlations with Visual Outcomes. Zabrina
Abdool1, 4, J. M. Provis1, 4, W. G. Campbell5, A. P.
Hunyor6, I. L. McAllister7, R. W. Essex2, 3. 1John
Curtin School of Medical Research, Australian
National University, Canberra, ACT, Australia;
2
Department of Ophthalmology, The Canberra
Hospital, Canberra, ACT, Australia; 3ANU Medical
School, Australian National University, Canberra,
ACT, Australia; 4ARC Centre of Excellence for
Vision Sciences, Australian National University,
Canberra, ACT, Australia; 5Vitreoretinal Unit, Royal
Victorian Eye and Ear Hospital, East Melbourne,
VIC, Australia; 6Retina Associates, Sydney Eye
Hospital, Sydney, NSW, Australia; 7Center for
Ophthalmology and Visual Science, Lions Eye
Institute, Perth, WA, Australia *CR
3850 — B0244 Clinical characteristics of
responders to intravitreal Bevacizumab in
central serous chorioretinopathy patients. Gyu
Ah Kim, T. Rim, C. S. Lee, S. Lee. Ophthalmology,
Yonsei Univ College of Medicine, Seoul, Republic
of Korea
3851 — B0245 Surgical Treatment of Lamellar
Macular Hole Associated with Epiretinal
Membrane and Prognostic Factors for Surgical
Outcome. Heeseong Yoon, S. Lee, W. Lee, K. Lee.
Sungmo Eye HospitaL, Busan, Republic of Korea
3852 — B0246 Development of BEST1 reporter
constructs for use in iPSC based high throughput
drug screens and disease modeling. Allison
Songstad1, E. R. Burnright1, R. F. Mullins1, E. M.
Stone1, 2, J. L. Andorf1, L. M. Streb1, X. Lu1, B. A.
Tucker1. 1Ophthalmology, Inst for Vision Rsrch,
Univ of Iowa, Iowa City, IA; 2Investigator, Howard
Hughes Medical Institute, Iowa City, IA *CR
3853 — B0247 Multifocal Electroretinography
(mfERG), Spectral-Domain Optical
Coherent Tomography (SD-OCT), Fundus
Autofluorescence (FAF) and Humphrey Visual
Fields (HVF) in Patients with Retinal Toxicity
Secondary to Plaquenil Therapy (PT). Inna V.
Glybina. Ophthalmology, Wayne State Univ/Kresge
Eye Inst, Detroit, MI
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
256
Tuesday – Posters – 3854 – 3871
Exhibit Hall B0318-B0328
Tuesday, May 07, 2013 2:45 PM-4:30 PM
Retina
377 CNV
Moderator: David Huang
3854 — B0318 Choroidal Neovascularization
Associated with Birdshot Chorioretinopathy.
Jessica Shantha1, V. Y. Ho1, P. Patel1, F.
Forooghian2, S. Yeh1. 1Emory University, Atlanta,
GA; 2St. Paul’s Hosptial, Vancouver, BC, Canada
*CR
3855 — B0319 Role of Periostin in Choroidal
Fibrovascular Membrane Formation. Takahito
Nakama1, S. Yoshida1, K. Ishikawa1, R. Asato1,
T. Kita1, S. Nakao1, Y. Sassa1, 2, Y. Oshima1, H.
Enaida1, T. Ishibashi1. 1Ophthalmology, Kyushu
University, Fukuoka, Japan; 2Ophthalmology,
Fukuoka University Chikushi Hospital, Fukuoka,
Japan
3856 — B0320 Long-term Effect of
Intravitreal Bevacizumab on Chorioretinal
Atrophy Progression in Myopic Choroidal
Neovascularization. Paolo Lanzetta, D. Veritti,
V. Sarao, S. Macor. Dept of Ophthalmology,
University of Udine, Udine, Italy *CR
3858 — B0322 Retinal Protection by
Lactoferrin in the Murine Laser Model of
Choroidal Neovascularization. Luke Dolezal1, K.
Mar2, A. A. Rageh2, M. Jordan3, D. A. Ferrington2,
S. R. Montezuma2. 1University of Minnesota
Medical School, Minneapolis, MN; 2Department
of Ophthalmology and Visual Neurosciences,
University of Minnesota, Minneapolis, MN;
3
University of North Dakota, School of Medicine
and Health Sciences, Grand Forks, ND
3859 — B0323 Intravitreal Bavacizumab for
Non-Subfoveal Choroidale Neovascularization
Associated with Angioid Streaks. Maurizio B.
Parodi1, P. Iacono2, U. Introini1, C. La Spina1, L.
Berchicci1, A. Leys3, F. Bandello1. 1Department of
Ophthalmology, Scientific Institute San Raffaele,
Milano, Italy; 2Fondazione G. B. Bietti per
l’Oftalmologia, IRCCS (Istituto di Ricovero e Cura
a Carattere Scientifico), Rome, Italy; 3Department
of Ophthalmology, University Hospital Leuven,
Leuven, Belgium *CR
3861 — B0325 Visual and anatomical outcomes
of intravitreal bevacizumab for idiopathic
choroidal neovascularization. Kahyun Lee, S. lee,
S. Kim, S. Byeon, C. S. Lee. Ophthalmology, Yonsei
university college of medicine, Seoul, Republic of
Korea
3862 — B0326 AntiVEGF treatment in myopic
CNVM: Patient and treatment characteristics.
Michelle V. Carle1, H. Tabandeh1, F. Boscia2, D. S.
Boyer1, T. G. Chu1, F. M. Rahhal1. 1Ophthalmology,
Retina Vitreous Associates, Los Angeles, CA;
2
University of Bari, Bari, Italy *CR
3863 — B0327 Treatment with Intravitreal
Anti-VEGF for Choroidal Neovascular
Membrane secondary to Sorsby’s Fundus
Dystrophy: A 24-Month Analysis. Guillermo
Fernandez Sanz1, R. Alonso-Gonzalez2, P. A.
Keane1, 3, E. Carreno1, G. Liew1, D. A. Sim1, 3, P. J.
Patel1, A. R. Webster1, 3, C. A. Egan1, 3, A. Tufail1,
3 1
. Medical Retina, Moorfields Eye Hospital,
London, United Kingdom; 2Adult Congenital Heart
Disease & Pulmonary Hypertension Centre, Royal
Brompton Hospital, London, United Kingdom;
3
UCL Institute of Ophthalmology, London, United
Kingdom *CR
3864 — B0328 Choroidal Thickness in
Pathologic Myopia. Cláudia Farinha1, A. Baltar1,
S. Nunes1, A. Santos2, M. Cachulo1, 2, I. Pires1, 2,
J. Figueira1, 2, R. Silva1, 3. 1Ophthalmology unit,
Centro Hospitalar e Universitário de Coimbra,
Coimbra, Portugal; 2Association for Innovation and
Biomedical Research on Light and Image, Coimbra,
Portugal; 3Faculty Medicine, University Coimbra,
Coimbra, Portugal *CR
Exhibit Hall D0109-D0157
Tuesday, May 07, 2013 2:45 PM-4:30 PM
Cornea
378 Corneal Wound Repair,
Transparency I
Moderator: Jodhbir S. Mehta
3865 — D0109 Inhibition of Kir4.1 (KCNJ10)
by miR-205 stimulates TGFA/EGF release in
human corneal epithelial cells. Daohong Lin, A.
Halilovic, S. Thomas, K. Wang, P. Yue, L. Bellner.
Pharmacology, New York Medical College,
Valhalla, NY
3866 — D0110 Effects of In-vivo Application
of Cold Atmospheric Plasma on Corneal Wound
Healing in New Zealand White Rabbits. Rashed
Alhabshan1, D. Belyea1, M. Stepp1, 2, J. Barratt1, S.
Grewal1, A. Shashurin3, M. Keidar3. 1Department
of Ophthalmology, George Washington University,
Washington, DC; 2Department of Anatomy
and Regenerative Biology, George Washington
University, Washington, DC; 3Department of
Mechanical and Aerospace Engineering, George
Washington University, Washington, DC
3867 — D0111 Corneal optical density during
Hyperbaric Oxygen Therapy. Knut Evanger1,
G. Vaagbø2, E. Thorsen2, 3, O. H. Haugen1, 4.
1
Institute of Clinical Medicine, University of
Bergen, Bergen, Norway; 2Hyperbaric Medicine
Unit, Dept. of Occupational Medicine, Haukeland
University Hospital, Bergen, Norway; 3Institute of
Medicine, University of Bergen, Bergen, Norway;
4
Department of Ophthalmology, Haukeland
University Hospital, Bergen, Norway f
3868 — D0112 Osteo-odonto-keratoprosthesis
(OOKP) and the testing of three different
adhesives for bonding bovine teeth with optical
PMMA cylinder. Kristin Weisshuhn1, I. Berg2, D.
Tinner3, C. Kunz2, M. M. Bornstein4, M. Steineck5,
K. Hille6, D. Goldblum1. 1Ophthalmology,
University Hospital Basel, Basel, Switzerland;
2
Maxillofacial Surgery, University Hospital
Basel, Basel, Switzerland; 3Practice of Dentistry
and Reconstruction, Basel, Switzerland; 4Oral
Surgery and Stomatology, School of Dental
Medicine, University Bern, Bern, Switzerland;
5
Dentistry, University Basel, Basel, Switzerland;
6
Ophthalmology, Ortenau Clinic Offenburg,
Offenburg, Germany
3869 — D0113 Difference in ocular damage by
40 and 95 GHz exposure to rabbit eye. Masami
Kojima1, 2, N. Hasanova1, H. Sasaki1, K. Sasaki1.
1
Vis Res for Environmtl Hlth/Med Res Inst,
Kanazawa Med Univ, Kahoku, Japan; 2Medical
Chemistry, Nursing school of Kanazawa Medical
University, Kahoku, Japan
3870 — D0114 Retinoids improvements during
the treatment by human amniotic membrane
of corneal alkali burns in a mouse model.
Nicolas Bonnin1, 2, L. Blanchon2, C. Belville2, 3,
G. Souteyrand1, F. Chiambaretta1, 2, V. Sapin2.
1
Ophthalmology, Gabriel Montpied Hospital,
Clermont-Ferrand, France; 2R2D2 EA7281,
Auvergne University, Clermont-Ferrand, France;
3
GRED INSERM 1103, Auvergne University,
Clermont-Ferrand, France
3871 — D0115 Examination of Corneal
Anatomy in Attempted Ninety Percent
Depth Suture Repair of Traumatic Corneal
Lacerations, Utilizing Post-Operative High
Resolution Anterior Segment OCT Imaging.
Alice C. Lorch, P. Veldman. Ophthalmology,
Massachusetts Eye & Ear Infirm, Boston, MA
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
257
Tuesday Posters
2:45 pm – 4:30 pm
3857 — B0321 Development of an Objective
Measurement Technique for Choroidal
Neovascularization Based on Fluorescein
Angiography. Christian R. Osswald1, M. J.
Guthrie1, N. L. Valio2, W. F. Mieler3, J. J. Kang
Mieler1. 1Biomedical Engineering, Illinois Institute
of Technology, Chicago, IL; 2Biological and
Chemical Sciences, Illinois Institute of Technology,
Chicago, IL; 3Ophthalmology & Visual Sciences,
University of Illinois at Chicago, Chicago, IL *CR
3860 — B0324 The incidence of
neovascolarization in the fellow eye of patients
with unilateral choroidal neovascolarization: a
survival analysis. Sara Bochicchio, R. Secondi, A.
Xhepa, A. Acquistapace, A. Giani, M. V. Cigada, G.
Staurenghi. Eye Clinic, Department of Biomedical
and Clinical Science “Luigi Sacco”, Luigi Sacco
Hospital, Milan, Italy *CR
3872 – 3893 – Tuesday – Posters
3872 — D0116 Transglutaminase-2 Knockdown
Effect Epithelial-Mesenchymal Transition during
Corneal Wound Healing. Aihua Hou1, L. Tong1, 2.
1
Singapore Eye Research Institute, Singapore,
Singapore; 2Singapore National Eye Center,
Singapore, Singapore
3873 — D0117 Ocular Phenotype and
Therapeutic Interventions in the Ectodermal
Dysplasia Keratitis-Ichthyosis-Deafness
Syndrome. David J. Armstrong1, M. Lagan1, J. E.
Sinton2, S. B. Kaye3, C. E. Willoughby4. 1Department
of Ophthalmology, Royal Victoria Hospital, Belfast,
United Kingdom; 2Department of Ophthalmology,
Altnagelvin Area Hospital, Londonderry, United
Kingdom; 3St Paul’s Eye Unit, Royal Liverpool
Hospital, Liverpool, United Kingdom; 4Centre
for Vision and Vascular Science, Royal Victoria
Hospital, Belfast, United Kingdom
3874 — D0118 Novel Therapeutic Strategies
for Corneal Trauma. Alex Cohen1, 2, T. M.
Boyce2, X. Gu2, 1, M. H. Elliott1, 2. 1Ophthalmology,
Dean McGee Eye Institute, Oklahoma City,
OK; 2Ophthalmology, University of Oklahoma,
Oklahoma City, OK
Tuesday Posters
2:45 pm – 4:30 pm
3875 — D0119 Impaired Wound Healing In
Corneal Stroma Of A Nitric Oxide Synthase
Type II -deficient Mouse. Takayoshi Sumioka1,
Y. Okada1, N. Fujita1, M. Miyajima2, S. Saika1.
1
Ophthalmology, Wakayama Medical University,
Wakayama, Japan; 2Laboratory Animal Center,
Wakayama Medical University, Wakayama, Japan
3876 — D0120 Method Development for
Evaluating Clear Corneal Cataract Wound
Integrity. Arthur Driscoll1, S. LaScalza2, P. K.
Jarrett1, M. McGrath1, M. Bassett1, A. S. Sawhney1.
1
R&D, Ocular Therapeutix, Bedford, MA; 2Clinical
Affairs, Ocular Therapeutix, Bedford, MA *CR
3877 — D0121 Effects of Transforming Growth
Factor Beta isoforms (TGFβs) On Diabetic
Corneal Wound Healing. Ilham Bettahi, F.
Wang, H. Sun, F. Yu. Ophthalmology, Wayne State
University, Detroite, MI
3878 — D0122 Nanoparticle Vectored
siRNAs Reduce Profibrotic Gene Expression in
Wounded Rabbit Corneas. Sriniwas Sriram1, P. M.
Robinson2, A. S. Lewin3, G. S. Schultz2. 1Biomedical
Engineering, University of Florida, Gainesville,
FL; 2Ob/Gyn and Opthalmology, University of
Florida, Gainesville, FL; 3Molecular Genetics and
Microbiology, University of Florida, Gainesville,
FL *CR
3879 — D0123 Aloe vera: An in-vitro study of
effects on corneal wound closure and collagenase
activity. Elizabeth Curto1, A. Labelle2, H. L.
Chandler1. 1The Ohio State University, Columbus,
OH; 2University of Illinois Urbana-Champaign,
Champaign, IL
3880 — D0124 Application of eye drops
for inhibiting scar formation using BMP-7
with excipients. Jin-Wook Jang1, H. Kim2, C.
Cho2, J. Kim3, J. Jang4, Y. Kim4, Y. Cho2. 1Yonsei
Univ., Seoul, Republic of Korea; 2Eyegene Inc.,
Seoul, Republic of Korea; 3B&VIIt Gangnam
Balgensesang Opthalmology Clinic, Seoul,
Republic of Korea; 4Korea Bone Bank Inc., Seoul,
Republic of Korea
3881 — D0125 Galectin-3 Enhanced
Epithelialization in Explanted Monkey Corneas
with Alkali Burn. Atsuko Fujii1, 2, T. R. Shearer2,
M. Azuma1, 2. 1Laboratory of Ocular Sciences,
Senju Pharmaceutical Co, Ltd., Beaverton, OR;
2
Department of Integrative Biosciences, Oregon
Health & Science University, Portland, OR *CR
3882 — D0126 MicroRNA-182 Inhibits
Human Corneal Epithelial Cell Proliferation
and Migration. Dongsheng Yan1, 2, X. Chen1, 2,
J. Wang1, 2, L. Tu1, 2. 1School of Optometry and
Ophthalmology, Wenzhou Medical College,
Wenzhou, China; 2State Key Laboratory Cultivation
Base and Key Laboratory of Vision Science,
Ministry of Health of P. R. China, Zhejiang
Provincial Key Laboratory of Ophthalmology and
Optometry, Wenzhou, China
3883 — D0127 The effects of IL-6 receptor
blockade on gene expressions in experimental
corneal alkali burn. Satoshi Sugaya, T. Sakimoto,
A. Yamada, T. Ohnishi, A. Ishimori, M. Sawa. Nihon
University school of medicine, Tokyo, Japan *CR
3884 — D0128 CD11b+GR1+ Myeloid Cells
Promote Trigeminal Ganglion Neurite Growth:
Implications for Corneal Nerve Regeneration.
Sonal Gandhi, J. Sarkar, W. Chamon, S. Chaudhary,
S. Tibrewal, Y. Byun, S. H. Jassim, A. Sharma, N.
Mohindra, S. Jain. Ophthalmology and Visual
Sciences, University of Illinois at Chicago, Chicago,
IL *CR
3885 — D0129 Semaphorin 7a actions on
nerves and myeloid cells in the cornea promote
nerve regeneration, thus linking neuronal
and myeloid systems. Sarmad H. Jassim, A.
Namavari, S. Chaudhary, S. Tibrewal, Y. Byun, S.
Gandhi, N. Mohindra, H. Lee, J. Sarkar, S. Jain.
Ophthalmology and Visual Sciences, University of
Illinois at Chicago, Chicago, IL *CR
3886 — D0130 The Role of Heat Shock Protein
27 and Signal Transduction Pathway of its
Phosphorylation in Corneal Epithelial Wound
Healing. Jae Yong Kim, S. Kang, I. Song, E. Kim,
M. Kim, H. Tchah. Ophthalmology, University of
Ulsan College of Medicine, Asan Medical Center,
Seoul, Republic of Korea
3889 — D0133 Wound healing in rabbit
corneas after flapless refractive lenticule
extraction with a novel 345nm ultraviolet
femtosecond laser. Christian M. Hammer1, J.
Menzel-Severing1, C. Petsch1, N. Polisetti1, B. O.
Bachmann1, J. Klenke2, K. Skerl2, C. Wüllner2,
C. Donitzky2, F. E. Kruse1. 1Department of
Ophthalmology, University of Erlangen-Nuernberg,
Erlangen, Germany; 2WaveLight GmbH (Alcon),
Erlangen, Germany *CR
3890 — D0134 Effect of fat-derived
mesenchymal stem cells on the corneal alkalie
burn injury in dogs. Young Sam Kwon. Veterinary
Surgery, Kyungpook National University, Daegu,
Republic of Korea
3891 — D0135 Optical coherence tomography
analysis of hydrofluoric acid decontamination
of human cornea by mannitol solution. Ricardo
Nose1, 2, F. B. Daga1, A. S. Forseto2, G. Victor2, S. J.
Sousa3, W. Nose2, N. Kasahara1. 1Santa Casa de Sao
Paulo, Sao Paulo, Brazil; 2Eye Clinic Day Hospital,
Sao Paulo, Brazil; 3Ophtalmoogy, Faculdade de
Medicina Universidade de São Paulo de Ribeirão
Preto, São Paulo, Brazil
3892 — D0136 Effect of human albumin
in combination of blood derivatives rich in
growth factors in the wound healing capability
of corneal epithelial cells. Noelia Andollo1,
V. Freire1, 4, A. E. Grau3, J. Etxebarria1, 5, J.
A. Duran2, 4, M. Morales5. 1Cell Biology And
Histology, University of The Basque Country,
BioCruces Health Research Institute, Leioa, Spain;
2
Ophthalmology, University of the Basque Country,
BioCruces Health Research Institute, Leioa, Spain;
3
Hospital Sótero del Rio, Santiago, Chile; 4R & D
Dept., Instituto Clínico-Quirúrgico de Oftalmología,
Bilbao, Spain; 5University Hospital of Cruces,
BioCruces Health Research Institute, Barakaldo,
Spain *CR
3893 — D0137 Cryopreservation Preserves the
Structural Integrity, Biochemical Components
and Biologic Function of Amniotic Membrane
Tissue. Ek Kia Tan1, 2, M. T. Cooke3, C. Mandrycky3,
H. He1, 2, J. O’Connell4, T. C. McDevitt3, 5, S.
C. Tseng1, 2. 1Ocular Surface Research and
Education Foundation, Miami, FL; 2Research
and Development, TissueTech, Inc., Miami, FL;
3
Wallace H. Coulter Department of Biomedical
Engineering, Georgia Institute of Technology
and Emory University, Atlanta, GA; 4Amniox
Medical, Marietta, GA; 5Parker H. Petit Institute for
Bioengineering and Bioscience, Georgia Institute of
Technology, Atlanta, GA *CR
3887 — D0131 Biological stability of Plasma
Rich in Growth Factors (PRGF-Endoret) eye
drops after 3 months of storage. Gorka Orive,
F. Muruzabal, A. Pino, E. Anitua. Biotechnology
Institute, Vitoria, Spain *CR
3888 — D0132 Proteome study of keratocytes
after PRGF-Endoret treatment. Francisco Jose
Muruzabal, G. Orive, E. Anitua. Biotechnology
Institute, Vitoria, Spain *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
258
Tuesday – Posters – 3894 – 3916
3894 — D0138 Biological Differences between
Cryopreserved and Dehydrated Amniotic
Membrane Tissue Grafts. Lorraine S. Chua1, 2, M.
T. Cooke3, C. Mandrycky3, E. Tan1, 2, J. O’Connell4,
S. C. Tseng1, 2, T. C. McDevitt3, 5. 1Ocular Surface
Research & Education Foundation, Miami, FL;
2
Research & Development, TissueTech, Inc.,
Miami, FL; 3Wallace H. Coulter Department of
Biomedical Engineering, Georgia Institute of
Technology and Emory University, Atlanta, GA;
4
Amniox Medical, Marietta, GA; 5Parker H. Petit
Institute for Bioengineering and Bioscience,
Georgia Institute of Technology, Atlanta, GA *CR
3895 — D0139 Covalently immobilized
epidermal growth factor accelerates proliferation
of human corneal epithelial cells. Shin Ae
Park1, V. K. Raghuanthan1, S. M. Thomasy1,
C. J. Murphy1, 2. 1Department of Surgical and
Radiological Sciences, UC Davis, Davis, CA;
2
Department of Ophthalmology & Vision Science,
UC Davis, CA, CA *CR
3896 — D0140 Substrate topography enhances
corneal epithelial cell electrotaxis. Brian Reid1,
J. Gao1, V. K. Raghuanthan2, P. Russell2, C. J.
Murphy2, 3, M. Zhao1, 3. 1Dermatology, University
of California, Davis, Davis, CA; 2Surgical and
Radiological Sciences, University of California,
Davis, Davis, CA; 3Ophthalmology and Vision
Science, University of California, Davis, Davis, CA
*CR
3898 — D0142 Dysregulated Heme OxygenaseFerritin System in Pterygium Pathogenesis. Lars
Bellner1, T. P. Fox1, K. H. Gotlinger1, M. W. Dunn2,
T. Milman3, G. W. Zaidman2, M. L. Schwartzman1, 2.
1
Pharmacology, New York Medical College,
Valhalla, NY; 2Ophthalmology, New York Medical
College, Valhalla, NY; 3New York Eye & Ear
Infirmary, New York, NY
3899 — D0143 Corneal Fibrosis Associated
with Trauma and Infection Using Mouse Models.
Hong-Yuan Zhu1, 2, J. P. Ng1, S. Salleh1, T. T.
Aung1, R. W. Beuerman1. 1Singapore Eye Research
Institute, Singapore, Singapore; 2Department
of Ophthalmology, Daqing People’s Hospital,
The Fifth Affiliated Hospital of Harbin Medical
University, Daqing, China *CR
3900 — D0144 Keratin films in Ocular Surface
Reconstruction:Biocompatibility experiments.
Nadine Joepen1, M. Borelli1, Y. Feng1, M. Schoppe1,
S. Reichl2, S. Schrader1, G. Geerling1. 1Duesseldorf
University, Duesseldorf, Germany; 2Institute of
Pharmaceutical Technologies, Braunschweig,
Germany *CR
3903 — D0147 Corneal Wound Healing Model
in New Zealand White Rabbits for Evaluating
Persistent Corneal Epithelial Defects. Glenwood
G. Gum1, B. M. Wirostko2, M. Rafii2, S. Pritt1, D.
Gutierrez1. 1Absorption Systems, San Diego, CA;
2
Jade Therapeudics, Salt Lake CIty, UT *CR
3904 — D0148 New medical device for chronic
corneal ulcers healing. Beatrice Cochener, S.
Derrien. Ophthalmologie, CHU De Brest, Brest,
France *CR
3905 — D0149 Induction of heat shock protein
70 ameliorates ultraviolet-induced photokeratitis
in mice. Nobuyoshi Kitaichi1, 2, A. Lennikov3, S.
Kase3, K. Noda3, Y. Horie3, S. Ohno2, S. Ishida3.
1
Ophthalmology, Health Sciences University of
Hokkaido, Sapporo, Japan; 2Ocular Inflammation
and Immunology, Hokkaido Univeristy
Graduate School of Medicine, Sapporo, Japan;
3
Ophthalmology, Hokkaido Univeristy Graduate
School of Medicine, Sapporo, Japan
3906 — D0150 Favorable effects of loss of
TRPM2 on the inflammation and scarring in an
alkali-burned cornea in mice. Yuka Okada1, K.
Shirai1, M. Miyajima2, S. Saika1. 1Ophthalmology,
Wakayama Medical University, Wakayama, Japan;
2
Laboratory Animal Center, Wakayama Medical
University, Wakayama, Japan
3907 — D0151 Role of Galectins in Corneal
Nerve Regeneration. Pedram Hamrah1, 2, Z.
Cao3, D. L. Harris1, 2, T. Thitiprasert3, L. Zheng1,
W. Chen3, W. Schrems1, T. Yamaguchi1, 2, N. A.
Panjwani3. 1Schepens Eye Research Institute/
Massachusetts Eye and Ear, Boston, MA;
2
Ophthalmology, Harvard Medical School, Boston,
MA; 3Ophthalmology, Tufts Medical School,
Boston, MA
3908 — D0152 Improvements in visual acuity
and function with Prosthetic Replacement of
the Ocular Surface Ecosystem scleral lens in
patients with ocular surface disease. Tova Mannis,
D. Bach, G. B. Chiu, S. R. Bababeygy, J. A. Irvine,
J. Heur. Department of Ophthalmology, Keck
School of Medicine of the University of Southern
California, Los Angeles, CA
3909 — D0153 A Standardized Regimen for
Extended-Wear Prosthetic Replacement of the
Ocular Surface Ecosystem (PROSE): Treatment
of Persistent Epithelial Defects. Jessica Ciralsky,
K. O. Chapman, M. N. Lee, M. Rosenblatt, P.
Sood, A. G. Alzaga Fernandez, K. C. Sippel. Weill
Cornell, New York, NY
3901 — D0145 Innervation of embryonic
corneas during wound healing. James W. Spurlin,
P. Y. Lwigale. Biochemistry and Cell Biology, Rice
University, Houston, TX
3910 — D0154 Corneal Wound Healing is
Facilitated by Hydroxamates that Reduce
EMMPRIN Expression. Marion K. Gordon1,
A. D. Rodrigues1, R. A. Hahn1, D. R. Gerecke1,
K. K. Svoboda2, N. D. Heindel3. 1Pharmacology
and Toxicology, EMSOP, Rutgers University,
Piscataway, NJ; 2Biomedical Sciences, Texas
A&M, Baylor College of Dentistry, Dallas, TX;
3
Chemistry, Lehigh University, Bethlehem, PA
3911 — D0155 An intracellular degradation
pathway implicated in corneal scarring. Audrey
Bernstein, L. Wang, S. R. Gillespie. Ophthalmology,
Mount Sinai School of Medicine, New York, NY
3912 — D0156 Mast Cells and the
Inflammatory Response to Corneal Epithelial
Abrasion. Alan R. Burns1, 2, Q. Liu2, Z. Li2, C. W.
Smith2. 1College of Optometry, University Eye
Institute, Houston, TX; 2Pediatrics/Leukocyte
Biology, Baylor College of Medicine, Houston, TX
3913 — D0157 Changes in Mouse Corneal
Epithelial Innervation After Injury. Lanny
Shulman1, S. D. Hanlon1, P. T. Landry1, C. W.
Smith2, A. R. Burns1, 2. 1College of Optometry,
University of Houston, Houston, TX; 2Department
of Leukocyte Biology, Baylor College of Medicine,
Houston, TX
Exhibit Hall D0202-D0254
Tuesday, May 07, 2013 2:45 PM-4:30 PM
Glaucoma
379 Perimetry II
Moderator: Shaban Demirel
3914 — D0202 A method to identify the edge of
visual field scotoma; the estimation of prediction
error of the visual field sensitivity is large at the
steep ‘edge’ of scotoma. Yuka Aoyama, H. Murata,
M. Tahara, M. Yanagisawa, C. Mayama, R. Asaoka.
University of Tokyo Graduate School of Medicine,
Tokyo, Japan
3915 — D0203 Exploration of the Dynamic
Range of the Moorfields MDT to Assess
Suitability to Monitor Glaucoma. Marco A.
Miranda1, G. M. Verdon-Roe1, C. Bergin1, T.
Redmond1, D. P. Crabb2, D. F. Garway-Heath1.
1
National Institute for Health Research (NIHR)
Biomedical Research Centre, Moorfields Eye
Hospital NHS Foundation Trust and UCL Institute
of Ophthalmology, London, United Kingdom;
2
Optometry and Visual Science, City University
London, London, United Kingdom *CR
3916 — D0204 Reclaiming the Periphery
- Frequency of Seeing for Static Automatic
Perimetry on Peripheral Isopters for Patients
with Glaucoma and Healthy Controls. Vera M.
Mönter1, 2, D. P. Crabb2, P. H. Artes1. 1Optometry
and Visual Science, City University London,
London, United Kingdom; 2Ophthalmology and
Visual Sciences, Dalhousie University, Halifax, NS,
Canada *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
259
Tuesday Posters
2:45 pm – 4:30 pm
3897 — D0141 Role of Soluble Vimentin in
Regulating the ERK Pathway during Corneal
Fibrosis. Paola Bargagna-Mohan, R. Mohan.
Neuroscience, Univ of Connecticut Health Center,
Farmington, CT *CR
3902 — D0146 Efficacy Studies of Histatin
for Corneal Wound Healing Utilizing a Rabbit
Model. Seth P. Epstein, N. Gadaria-Rathod, K.
Fernandez, P. A. Asbell. Ophthalmology, Mount
Sinai School of Medicine, New York, NY *CR
3917 – 3941 – Tuesday – Posters
3917 — D0205 Mechanisms Underlying
Frequency-Doubling Technology (FDT) in
Glaucoma. Michele D. Lee1, J. Wielaard1, J. H.
Acton1, 3, S. Boddu1, S. Park2, J. M. Liebmann1, 2, R.
Smith1. 1Opthalmology, New York University, New
York, NY; 2Ophthalmology, New York Eye and Ear
Infirmary, New York, NY; 3School of Optometry
and Visual Sciences, Cardiff University, Wales,
United Kingdom *CR
3925 — D0213 Feasibility of the Moorfields
Motion Displacement Test for community
based glaucoma screening. Carmen GonzalezAlvarez1, 2, R. Antonio Manuel2, J. Loughman1, 3.
1
Department of Optometry, Dublin Institute of
Technology, Dublin, Ireland; 2Departamento de
Ciencias de Saude, Universidad de Lurio, Nampula,
Mozambique; 3African Vision Research Institute,
University of ZwaZulu Natal, Durban, South Africa
3918 — D0206 The Effects of Trabeculectomy
on the Fast and Slow Components of Visual
Field Rates. Parham Azarbod1, 2, K. NouriMahdavi2, E. Morales2, F. Yu2, A. Afifi2, A.
L. Coleman2, J. Caprioli2. 1Ophthalmology,
Moorfields Eye Hospital, London, United Kingdom;
2
Ophthalmology, Jules Stein Eye Institute, Los
Angeles, CA *CR
3926 — D0214 Obstacle crossing in patients
with glaucoma in different lighting conditions.
Amy C. Scarfe, M. A. Timmis, R. R. Bourne, D. R.
Tabrett, S. Pardhan. Vision and Eye Research Unit
(VERU), Postgraduate Medical Institute, Anglia
Ruskin University, Cambridge, United Kingdom *CR
3919 — D0207 The Effect of Eccentricity on
the Test-Retest Characteristics of Standard
Automated Perimetry in Glaucoma. Sarah L.
Bishop1, Y. Ho1, D. Goren2, J. G. Flanagan1, 3.
1
School of Optometry and Vision Sciences,
Univeristy of Waterloo, Waterloo, ON, Canada;
2
Devers Eye Institute, Legacy Research Institue,
Portland, OR; 3Ophthalmology and Vision Science,
Univeristy of Toronto, Toronto, ON, Canada *CR
Tuesday Posters
2:45 pm – 4:30 pm
3920 — D0208 Assessing the Reliability of
Humphrey Visual Field Testing in an Urban
Population. Manal H. Peracha, B. A. Hughes, J.
Tannir, R. Momi, A. Goyal, M. S. Juzych, C. Kim,
M. McQueen, A. M. Eby, F. Fatima. Kresge Eye
Institute, Wayne State University, Grosse Ile, MI
3921 — D0209 Visual Field Progression Rate of
Different Glaucomatous Optic Disc Phenotypes
in Progressive Open-Angle Glaucoma. Jong Rak
Lee, K. Lee, M. S. Kook. Ophthalmology, Asan
medical center, Seoul, Republic of Korea
3922 — D0210 Useful Diagnostic Tool for
Progressive Visual Acuity Decrease in Glaucoma
Patients. Takeshi Yabana, K. Omodaka, M.
Takahashi, N. Himori, M. Ryu, K. Maruyama, T.
Nakazawa. Tohoku university, Sendai, Japan *CR
3923 — D0211 Simulated visual field using
macular RNFLT in patients with glaucoma.
Mai Takahashi, K. Omodaka, N. Himori, M. Ryu,
T. Nakazawa. Ophthalmology, Tohoku University
Graduate School of Medicine, Sendai, Japan *CR
3924 — D0212 Temporal summation varies
with visual field eccentricity for perimetric
stimuli scaled to the area of complete spatial
summation. Padraig J. Mulholland1, 2, T.
Redmond3, 2, M. B. Zlatkova1, D. F. GarwayHeath2, R. S. Anderson1, 2. 1School of Biomedical
Sciences, University of Ulster, Coleraine, United
Kingdom; 2NIHR Biomedical Research Centre at
Moorfields Eye Hospital NHS Foundation Trust
and UCL Institute of Ophthalmology, London,
United Kingdom; 3School of Optometry and Vision
Sciences, Cardiff University, Cardiff, United
Kingdom *CR
3927 — D0215 Acute Intraocular Pressure
Elevation in Mice Results in Diminished Scotopic
and Photopic Contrast Sensitivity. Benjamin J.
Frankfort, M. E. van der Heijden, C. S. Cowan,
S. M. Wu. Ophthalmology, Baylor College of
Medicine, Houston, TX
3928 — D0216 Smoothing Algorithms for
Pointwise Visual Field Predictions in Glaucoma.
Esteban Morales1, P. Azarbod1, A. Afifi2, F. Yu2,
A. L. Coleman3, K. Nouri-Mahdavi1, J. Caprioli1.
1
Ophthalmology, University of California,
Los Angeles, Los Angeles, CA; 2Biostatistics,
University of California, Los Angeles, Los Angeles,
CA; 3Epidemiology, University of California, Los
Angeles, Los Angeles, CA *CR
3929 — D0217 Performance of the Visual
Field Index in Patients with Advanced Field
Loss. Meera Ramanathan1, J. Lee1, N. Cirineo1,
A. Afifi2, E. Morales1, F. Yu1, 2, K. Nouri-Mahdavi1,
A. L. Coleman1, 3, J. Caprioli1. 1Ophthalmology,
Jules Stein Eye Institute, University of California
at Los Angeles, Los Angeles, CA; 2Biostatistics,
Karin Fielding School of Public Health, University
of California at Los Angeles, Los Angeles, CA;
3
Epidemiology, Karin Fielding School of Public
Health, University of California at Los Angeles, Los
Angeles, CA *CR
3930 — D0218 The Relationship Between
Visual Acuity, Intraocular Pressure, and
Rates of Visual Field Progression Using 10-2
Perimetry. Carly J. Seidman1, C. De Moraes1, 2,
R. L. Furlanetto2, J. M. Liebmann1, 2, R. Ritch2, 3.
1
New York University School of Medicine, New
York, NY; 2Einhorn Clinical Research Center,
New York Eye and Ear Infirmary, New York, NY;
3
Ophthalmology, New York Medical College, New
York, NY *CR
3931 — D0219 Temporal filtering of
longitudinal visual field data. Chris A. Johnson1,
C. K. Doyle1, 2, T. Eden1, 2, M. Wall2, 3. 1Ophthal
& Visual Sci, University of Iowa, Iowa City, IA;
2
Neurology, University of Iowa, Iowa City, IA;
3
Neurology, Veterans Administration, Iowa City,
IA *CR
3932 — D0220 Influence of prior information
on Bayesian estimators of visual field
progression. Andrew J. Anderson. Optometry &
Vision Sciences, The University of Melbourne,
Parkville, VIC, Australia
3933 — D0221 The relationship between
visual acuity and central visual field on vision
related quality of life in advanced glaucomatous
patients. Mizu Okamoto1, H. Murata1, M.
Araie1, 2, H. Hirasawa1, C. Mayama1, R. Asaoka1.
1
Ophthalmology, University of Tokyo school of
Medicine, Tokyo, Japan; 2Kanto Central Hospital,
Tokyo, Japan *CR
3934 — D0222 Cluster-Based Trend Analysis of
Visual Field Progression in Low Tension and High
Tension Open-Angle Glaucoma. Iman Goharian,
D. S. Greenfield, M. Sehi. Bascom Palmer Eye
Institute, Palm Beach Gardens, FL *CR, f
3935 — D0223 The Evaluation of Driving
Performance in Glaucoma Patients Using
Binocular or Monocular Visual Field
Parameters. Chauyin Chen. Ophthalmology, Chang
Gung Memorial Hospital, Pu Zih City, Chia-yi,
Taiwan
3936 — D0224 Unusual Cause of High
Fixation Loss Rate during Standard Automated
Perimetry Testing. Tamara L. Berezina, E.
Buroff, A. S. Khouri, A. Cohen, R. D. Fechtner.
Ophthalmology, UMDNJ-New Jersey Medical
School, Newark, NJ
3937 — D0225 Glaucoma Monitoring
with Frequency Doubling Perimetry in the
Groningen Longitudinal Glaucoma Study.
Christiaan Wesselink1, N. M. Jansonius1, 2. 1Dept.
of Ophthalmology, University Medical Center
Groningen, Groningen, Netherlands; 2Dept. of
Epidemiology, Erasmus Medical Center, Rotterdam,
Netherlands
3938 — D0226 Comparison of Web-based
Perimetry and office-based Humphrey Visual
Field (HVF) in Patients with Glaucoma. Jing
Hou1, 2, S. K. Wang3, J. D. Keenan2, B. Chon2,
N. Subramanian2, T. Ianchulev4, R. L. Stamper2,
R. Chang3, Y. Han2. 1Ophthalmology, People’s
Hospital, Peking University, Beijing, China;
2
Ophthalmology, University California, San
Francisco, San Francisco, CA; 3Ophthalmology,
Stanford University, Palo Alto, CA; 4Transcend
Medical, Palo Alto, CA *CR
3939 — D0227 Adaptation abnormalities in
Primary Open-Angle Glaucoma. Shira Radner,
R. Ennis, B. Lee, M. W. Dul, Q. Zaidi. Graduate
Department of Biological and Vision Sciences,
SUNY State College of Optometry, New York, NY
3940 — D0228 Accuracy of sensitivities
measured by perimetry at damaged locations
in subjects with glaucoma. Deborah Goren1, S.
Demirel1, C. Goldman1, W. H. Swanson2, S. K.
Gardiner1. 1Devers Eye Institute, Legacy Research
Institute, Portland, OR; 2School of Optometry,
Indiana University, Bloomington, IN *CR
3941 — D0229 Reduced Central Visual Field
Sensitivity in Glaucoma Patients With Normal
10-2 Visual Fields Compared to Healthy
Controls. Lyne Racette, A. N. Goad, L. S. Morgan,
J. S. Hoop, J. Eikenberry, D. WuDunn, B. C.
Samuels, A. Tyring, A. T. Phan. Eugene & Marilyn
Glick Eye Inst, Indiana University, Indianapolis,
IN *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
260
Tuesday – Posters – 3942 – 3962
3942 — D0230 Linear, Tobit and Nonlinear
Exponential Regression Modeling of Visual
Field Data. Colleen Kummet1, G. J. Zamba3, T. L.
Burns1, P. Romitti1, P. H. Artes2, C. K. Doyle5, C. A.
Johnson4, M. Wall4, 5. 1Epidemiology, University of
Iowa, Iowa City, IA; 2Dalhousie University, Halifax,
NS, Canada; 3Biostatistics, University of Iowa,
Iowa City, IA; 4Ophthalmology, University of Iowa,
Iowa City, IA; 5VA Health Care System, Iowa City,
IA *CR
3949 — D0237 Expert Evaluation of Visual
Field Change in Glaucoma Correlates Better
With the Measured Fast Component of Visual
Field Loss. Nila Cirineo1, K. Nouri-Mahdavi1, J.
Lee1, M. Ramanathan1, E. Morales1, F. Yu1, 2, A.
Afifi2, A. L. Coleman1, 3, J. Caprioli1. 1Opthalmology,
Jules Stein Eye Institute, Los Angeles, CA;
2
Biostatistics, School of Public Health at UCLA,
Los Angeles, CA; 3Epidemiology, School of Public
Health at UCLA, Los Angeles, CA *CR
3956 — D0244 Personalizing the Frequency
and Timing of Testing to Check for Glaucoma
Progression: a Novel Approach. Mariel
Lavieri1, J. Helm3, G. Schell1, M. Van Oyen1, D.
C. Musch2, J. D. Stein2. 1Industrial and Operations
Engineering, University of Michigan, Ann Arbor,
MI; 2Department of Ophthalmology and Visual
Sciences, University of Michigan, Ann Arbor, MI;
3
Kelley School of Business, Indiana University,
Bloomington, IN *CR
3943 — D0231 Automated stimulus choice in
condensed grids for assessment of visual field
defects. Luke X. Chong1, A. M. McKendrick1, A.
Turpin2. 1Department of Optometry and Vision
Sciences, The University of Melbourne, Parkville,
VIC, Australia; 2Department of Computing and
Information Systems, The University of Melbourne,
Parkville, VIC, Australia *CR
3950 — D0238 Noise-Corrected Event Analysis
of Automated Visual Fields. David W. Richards, Z.
Khan. Ophthalmology, Univ of South Florida Coll
of Med, Tampa, FL
3957 — D0245 Comparison of perimetric
results with the Humphrey and Mon-CV3
perimeters. Jesus Jimenez-Roman, C. Riveros, L.
A. Zarate, M. Turati, F. Gil Carrasco. Glaucoma,
APEC, Mexico, Mexico
3944 — D0232 Novel Technique: A
Pupillometer-Based Objective Chromatic
Perimetry. Ygal Rotenstreich1, A. Skaat1, I.
Sher-Rosenthal1, A. F. Kolker2, E. Rosenfeld1, S.
Melamed1, M. Belkin1. 1Goldschleger Eye Research
Institute, Sheba Medical Center, Tel Hashomer,
Israel; 2Department of Ophthalmology, George
Washington University, Washington, DC *CR, f
3945 — D0233 Longitudinal analysis of
Glaucoma Suspects from the Erlangen glaucoma
registry (EGR): Influence of neuroretinal rim area
and visual field indices on Progression. Hohberger
Bettina, F. K. Horn, A. G. Junemann, R. Laemmer.
University Erlangen, Erlangen, Germany f
3947 — D0235 A novel system to detect the
progression of glaucomatous visual field damage:
aggregating the results of point-wise analysis
with the binomial test. Hiroshi Murata, A.
Karakawa, H. Hirasawa, C. Mayama, M. Aihara,
R. Asaoka. Ophthalmology, University of Tokyo,
Tokyo, Japan *CR
3948 — D0236 Relationship between Corneal
Hysteresis and Visual Field Progression in
Glaucoma and Ocular Hypertensive Eyes.
Marta Pazos1, A. Anton1, 2, M. López-Valladares3,
V. Díaz-Alemán4, M. Fallon2. 1Ophthalmology.
Glaucoma., Hospital de l’Esperança. Parc
de Salut Mar., Barcelona, Spain; 2Glaucoma.
Research., Institut Català de la Retina., Barcelona,
Spain; 3Opthhalmology. Glaucoma., Complexo
Hospitalario Universitario de Santiago de
Compostela, Santiago de Compostela, Spain;
4
Opthalmology. Glaucoma., Hospital Universitario
de Canarias, Tenerife, Spain *CR
3952 — D0240 Comparing performance of
the Flicker-Defined Form (FDF) stimulus and
Standard Automated Perimetry (SAP) using the
Heidelberg Edge Perimeter (HEP) in patients
newly referred with suspect glaucoma. Csilla
Ajtony1, G. Nithyanandarajah1, R. R. Bourne1, 2. 11.
NIHR Biomedical Research Centre at Moorfields
Eye Hospital NHS Foundation Trust, UCL Institute
of Ophthalmology, London, United Kingdom;
2
Vision & Eye Research Unit, Postgraduate Medical
Institute, Anglia Ruskin University, Cambridge,
United Kingdom *CR
3953 — D0241 Eye Movement Perimetry in
Glaucoma Patients. Alice Xu1, D. E. Warren2, C.
K. Doyle3, 4, A. Papendieck1, M. J. Thurtell3, 4, M.
Wall3, 4. 1Carver College of Medicine, Iowa City,
IA; 2Department of Neurology, University of Iowa,
Iowa City, IA; 3Iowa City VA Health Care System,
Iowa City, IA; 4Department of Ophthalmology,
University of Iowa, Iowa City, IA
3954 — D0242 The ability of Moorfields
Motion displacement visual field test to
discriminate different stages of glaucoma.
Robert L. Stamper, O. Chansanti, N. Subramanian.
Ophthalmology, Univ California-San Francisco, San
Francisco, CA *CR
3955 — D0243 Detection of Glaucomatous
Progression Comparing SITA Standard and
Matrix Perimetry. Michael Wall1, 2, C. K. Doyle1, 2,
T. Eden1, 2, C. A. Johnson2, G. J. Zamba3. 1Iowa
City VA Health Care System, Iowa City, IA;
2
Ophthalmology and Visual Sciences, University of
Iowa, Carver College of Medicine, Iowa City, IA;
3
Biostatistics, University of Iowa, College of Public
Health, Iowa City, IA *CR
3958 — D0246 Clinical Utility of Web-based
Office and Home Peristat for the Detection of
Visual Field Defects in Patients with Glaucoma.
Sean K. Wang1, J. Hou2, S. Ianchulev2, B. Chon2, Y.
Han2, R. Chang1. 1Stanford University, Stanford,
CA; 2University of California, San Francisco, San
Francisco, CA *CR
3959 — D0247 A novel method to predicting
quality of visual life and identifying essential
visual field locations. Hiroyo Hirasawa1, H.
Murata1, Y. Aoyama1, M. Araie2, C. Mayama1, M.
Aihara3, 1, R. Asaoka1. 1Ophthalmology, University
of Tokyo Graduate School of Medicine, Tokyo,
Japan; 2Kanto Central Hospital, the Mutual Aid
Association of Public School Teachers, Tokyo,
Japan; 3Shirato Eye Clinic, Tokyo, Japan *CR
3960 — D0248 Effect of Exposure to Computer
Simulated Visual Field Test on Variability of Test
Results. Justin Hellman1, S. Smith1, J. Schmidt2, 3,
A. Gerhard2, 3, M. Sanchez2, 3, F. Mellado2, E. A.
Maul2, 3, P. Y. Ramulu4. 1University Of Chicago
Pritzker School of Medicine, Chicago, IL;
2
Ophthalmology, Pontificia Universidad Catolica de
Chile, Santiago, Chile; 3Ophthalmology, Hospital
Sotero del Rio, Santiago, Chile; 4Johns Hopkins
Wilmer Eye Institute, Baltimore, MD f
3961 — D0249 Persistence of Glaucoma
Therapy and Visual Field Progression. John
Mark S. de Leon1, D. T. Quek2, H. M. Htoon1, E. L.
Lamoureux3, T. Aung1, 2. 1Singapore Eye Research
institute, Singapore, Singapore; 2Glaucoma,
Singapore National Eye Center, Singapore,
Singapore; 3Ophthalmology, University of
Melbourne, Melbourne, VIC, Australia *CR
3962 — D0250 Finding Patterns in
Glaucomatous Visual Field Loss: Components,
Prototypes, and Archetypes. Tobias Elze1, L. R.
Pasquale2, L. Q. Shen2, A. Turalba2, T. C. Chen2, D.
J. Rhee2, J. L. Wiggs2, C. Grosskreutz2, S. Brauner2,
P. Bex1. 1Schepens Eye Research Institute, Harvard
Medical School, Boston, MA; 2Massachusetts Eye
and Ear Infirmary, Boston, MA *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
261
Tuesday Posters
2:45 pm – 4:30 pm
3946 — D0234 Relationship between Target
Speed and Simple Visual Reaction Time
Measured at the Location of Kinetic Threshold
using Automated Kinetic Perimetry. Tomoyasu
Kayazawa1, C. Matsumoto1, S. Okuyama1, S.
Hashimoto1, E. Koike2, H. Nomoto1, F. Tanabe1, M.
Eura1, T. Numata1, Y. Shimomura1. 1Department
of Ophthalmology, Kinki University Fac,
Osaka-Sayama City, Japan; 2Department of
Ophthalomology, Sakai Hospital Kinki University
Fac, Sakai City, Japan
3951 — D0239 Detection of Functional Defect
in Early Glaucoma using Standard Automated
Perimetry and Flicker Defined Form Perimetry.
Yuan-Hao (Derek) Ho1, J. G. Flanagan1, 2. 1School
of Optometry and Vision Science, University of
Waterloo, Waterloo, ON, Canada; 2Department of
Ophthalmology & Vision Science, University of
Toronto, Toronto Western Hospital, Toronto, ON,
Canada *CR
3963 – 3980 – Tuesday – Posters
3963 — D0251 Getting the timing right:
Clustered volley stimulus presentation for
multifocal pupil perimetry in glaucoma. Corinne
F. Carle1, 2, A. C. James1, 2, M. Kolic1, 2, R. W.
Essex1, 3, T. Maddess1, 2. 1ARC Centre of Excellence
in Vis. Science, The Australian National University,
Canberra, ACT, Australia; 2Eccles Institute of
Neuroscience, The Australian National University,
Canberra, ACT, Australia; 3Ophthalmology Dept,
The Canberra Hospital, Garran, ACT, Australia *CR
3964 — D0252 Glaucoma alters rapid contrast
adaptation. Jia Jia Lek, A. J. Vingrys, A. M.
McKendrick. Optometry and Vision Sciences,
The University of Melbourne, Melbourne, VIC,
Australia *CR
3965 — D0253 Weighting of Visual Field Mean
Deviation according to Test-Retest Variability
of Pointwise Thresholds. Nariman Nassiri, S. K.
Law, A. L. Coleman, J. Caprioli, K. Nouri-Mahdavi.
Ophthalmology, Jules Stein Eye Institute/UCLA,
Los Angeles, CA *CR
Tuesday Posters
2:45 pm – 4:30 pm
3966 — D0254 Initial Central versus
Peripheral Visual Field Defects in Normal
Tension Glaucoma Patients: Clinical
Characteristics and Progression rates. Myungwon
Lee1, H. Cho2, J. Lee3, C. Kee2. 1Department of
Ophthalmology, Dankook University Hospital,
Cheonan, Republic of Korea; 2Department of
Ophthalmology, Samsung Medical Hospital, Seoul,
Republic of Korea; 3Department of Ophthalmology,
Yonseiplus Eye Center, Sungnam, Republic of
Korea
Exhibit Hall D0368-D0383
Tuesday, May 07, 2013 2:45 PM-4:30 PM
Anatomy/Pathology
380 Retinoblastoma: Experimental
and Clinical
Moderators: Timothy W. Corson and
Matthew W. Wilson
3967 — D0368 Optical coherence tomography
for screening of orthotopic retinoblastoma
xenografts. Andrea Wenzel1, B. C. Samuels1,
T. W. Corson1, 2. 1Ophthalmology, Indiana
University School of Medicine, Indianapolis, IN;
2
Biochemistry and Molecular Biology, Indiana
University School of Medicine, Indianapolis, IN
*CR
3968 — D0369 Gene expression signature of
putative Cancer Stem Cells in Retinoblastoma
Y79 cell line. Rohini M. Nair1, M. Balla2, I. Khan3,
R. Kalathur3, P. Kondaiah3, S. Honavar4, M. J. Ali4,
G. K. Vemuganti1. 1School of Medical Sciences,
University of Hyderabad, Hyderabad, India;
2
Ophthalmic Pathology Laboratory, L.V.Prasad
Eye Institute, Hyderabad, India; 3Molecular
Reproduction, Development and Genetics, Indian
Institute of Science, Bangalore, India; 4Ophthalmic
and Facial Plastic Surgery, Orbit and Ocular
Oncology, L.V.Prasad Eye Institute, Hyderabad,
India
3969 — D0370 Role of miR 106 - 25 family
in Retinoblastoma tumouriogenesis: in-vitro
analysis of their functions using antagomirs.
Subramanian Krishnakumar1, N. Venkatesan1, V.
Khetan2, M. A. Reddy3. 1L&T Ocular Pathology,
Vision Research Foundation, Chennai, India; 2Shri
Bhagwan Mahavir vitreoretinal services, Medical
Research Foundation, Chennai, India; 3Ocular
oncology, Moorfields Eye Hospital Trust, Barts and
London NHS Trust, London, United Kingdom
3970 — D0371 Immunohistochemical
Analysis of PDGFR-α, PDGFR-β & c-Abl
in Retinoblastoma: Potential therapeutic
targets. Mali Worme3, L. Rielo de Moura3, 2, D.
Sanft3, B. F. Fernandes1, 3, E. Antecka3, M. N.
Burnier3, 1. 1Ophthalmology and Pathology, The
McGill University Health Center, Montreal, QC,
Canada; 2Instituto Brasileiro de Oftalmologia,
Rio de Janeiro, Brazil; 3Henry C. Witelson Ocular
Pathology Laboratory, Montreal, QC, Canada
3971 — D0372 The role of endothelial
progenitor cell in the tumor angiogenesis of
retinoblastoma. Dong Hyun Kim1, 2, S. Park1, 2, B.
Lee1, 2, D. Jo1, 2, J. Kim1, J. Kim1, 2. 1Fight against
Angiogenesis-Related Blindness Laboratory,
Clinical Research Institute, Seoul National
University Hospital, Seoul, Republic of Korea;
2
Department of Ophthalmology, Seoul National
University Hospital, Seoul, Republic of Korea
3972 — D0373 Metformin affects the growth
and redox state of human retinobastoma cells.
Katarzyna A. Brodowska, E. S. Gragoudas, D.
Vavvas. Mass Eye and Ear Infirmary, Boston, MA
*CR
3973 — D0374 Small-Gauge Needles and
the Potential for Tumor Cell Seeding of
Retinoblastoma and Melanoma. Abby Y. Liu, H.
E. Grossniklaus. Emory Eye Center, Decatur, GA
3974 — D0375 Spatiotemporal Patterns of
Intraocular Tumor Occurrence in Children with
Retinoblastoma. Benjamin King1, 2, C. Parra2, 3,
M. W. Wilson5, 4, R. J. Ogg2. 1College of Medicine,
University of Tennessee Health Sciences Center,
Memphis, TN; 2Radiological Sciences, St. Jude
Children’s Research Hospital, Memphis, TN;
3
Biomedical Engineering, University of Memphis,
Memphis, TN; 4Surgery, St. Jude Children’s
Research Hospital, Memphis, TN; 5Ophthalmology,
University of Tennessee Health Sciences Center,
Memphis, TN
3975 — D0376 Shifting Treatment Paradigms
in Retinoblastoma: Dilemmas for the clinician in
evaluating the use of novel therapies. Timothy G.
Murray. 1Ophthalmology, Murray Ocular Oncology
and Retina, Miami, FL; 2Ophthalmology, Miami
Childrens Hospital, Miami, FL
3976 — D0377 Genetic Characterization
among 232 Retinoblastoma Patients. Jacob
Pe’er1, O. Zloto1, M. Weintraub2, M. Sagi3, I.
Lerer3, A. Nadel3, I. Rot2, N. Shoshani2, S. Frenkel1.
1
Ophthalmology, Hadassah-Hebrew University
Medical Center, Jerusalem, Israel; 2Pediatric
Hematology-Oncology, Hadassah-Hebrew
University Medical Center, Jerusalem, Israel;
3
Genetics, Hadassah-Hebrew University Medical
Center, Jerusalem, Israel
3977 — D0378 Topotecan and
Cyclophosphamide as Salvage Therapy in the
Treatment of Retinoblastoma. Qi N. Cui1, V.
Aivaliotis1, J. M. O’Brien2, P. Stewart1. 1Department
of Ophthalmology, University of California, San
Francisco, San Francisco, CA; 2Department of
Ophthalmology, University of Pennsylvania,
Philadelphia, PA
3978 — D0379 Non-selectivity of ERG
reductions in eyes treated for retinoblastoma.
Catherine Y. Liu1, G. Jonna1, J. H. Francis1,
B. Marr1, 3, D. H. Abramson1, 3, S. E. Brodie1, 2.
1
Ophthalmic Oncology, Memorial Sloan Kettering
Cancer Center, New York, NY; 2Ophthalmology,
Mt. Sinai Hospital, New York, NY; 3Weill-Cornell
Medical College, New York, NY
3979 — D0380 Electroretinogram
monitoring of retinal toxicity of ophthalmic
artery chemosurgery for retinoblastoma:
Six year experience. Jasmine H. Francis1,
D. H. Abramson1, 2, P. Y. Gobin3, B. Marr1, 2,
I. J. Dunkel4, E. R. Riedel5, S. E. Brodie6, 1.
1
Ophthalmic Oncology, Memorial Sloan Kettering
Cancer Center, New York, NY; 2Department of
Ophthalmology, Weill Cornell Medical College
of New York Presbyterian, New York, NY;
3
Department of Neurosurgery, Weill Cornell
Medical College of New York Presbyterian, New
York, NY; 4Department of Pediatrics, Memorial
Sloan Kettering, New York, NY; 5Department
of Epidemiology and Biostatistics, Memorial
Sloan Kettering, New York, NY; 6Department of
Ophthalmology, Mount Sinai School of Medicine,
New York, NY
3980 — D0381 Retcam Fluorescein
angiography findings in eyes with advanced
retinoblastoma. Yohko Murakami1, L. Ngai1, J. W.
Kim2, 1. 1Ophthalmology, Doheny Eye Institute, Los
Angeles, CA; 2Children’s Hospital Los Angeles, Los
Angeles, CA
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
262
Tuesday – Posters – 3981 – 3999
3981 — D0382 Radiation induced cataract
surgery in patients treated for retinoblastoma.
Carlos Y. Chen1, G. Márquez2, H. C. Matiz2, F.
Graue1, N. C. Lara3, M. Ramírez3. 1Retina and
Vitreous, Inst de Oftalmol Conde de Valenciana,
Mexico City, Mexico; 2Anterior Segment, Inst
de Oftalmol Conde de Valenciana, Mexico City,
Mexico; 3Ophthalmology, Hospital Infantil de
México Federico Gómez, Mexico City, Mexico
3982 — D0383 Intraocular Calcification as a
Diagnostic Marker for Retinoblastoma. Wendy
Ma1, M. M. Bloomer2, T. Rutar2. 1UCSF School of
Medicine, San Francisco, CA; 2Ophthalmology,
University of California, San Francisco, San
Francisco, CA
Exhibit Hall D0396-D0412
Tuesday, May 07, 2013 2:45 PM-4:30 PM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology
381 Amblyopia: Detection, Treatment
and Mechanisms
Moderator: Robert F. Hess
3983 — D0396 Comparison of a goldstandard cycloplegic refraction to a cycloplegic
autorefraction using the Retinomax K-plus3 on
children. Kyle Kravetz, N. S. Matta, D. I. Silbert.
Family Eye Group, Lancaster, PA *CR
3985 — D0398 Comparing Failure Criteria
for a New PC-Based Pediatric Vision-Screening
Test. Tomohiko Yamada1, D. A. Leske1, P. S. Moke2,
N. L. Parrucci2, J. B. Ruben3, J. M. Holmes1.
1
Ophthalmology, Mayo Clinic, Rochester, MN;
2
Jaeb Center for Health Research, Tampa, MN; 3The
Permanente Medical Group, Sacramento, CA
3986 — D0399 A Novel Pediatric Vision
Screener Employing Wave-Plate-Enhanced,
Retinal-Birefringence-Scanning-Based
Strabismus Detection and Double-Pass Focus
Detection. Kristina Irsch, B. I. Gramatikov, Y. Wu,
D. L. Guyton. The Wilmer Eye Institute, The Johns
Hopkins University School of Medicine, Baltimore,
MD *CR
3987 — D0400 Disinvestment of populationbased preverbal vision screening in the
Netherlands. Frea Sloot1, E. L. Bresser1, S. E.
Loudon1, T. Sjoerdsma4, J. Benjamins3, H. Raat2,
H. J. Simonsz1. 1Ophthalmology, Erasmus MC,
Rotterdam, Netherlands; 2Public Health, Erasmus
MC, Rotterdam, Netherlands; 3Icare, Meppel,
Netherlands; 4Public Health Service Amsterdam,
Amsterdam, Netherlands
3989 — D0402 Measuring wearing times
of glasses/patches using a well evaluated and
safe orthodontic thermosensor device. Kai
Januschowski1, T. E. Bechtold2, S. C. Schott2,
M. S. Huelber-Januschowski3, G. Blumenstock4,
K. U. Bartz-Schmidt1, D. Besch1, C. Schramm1.
1
Department of Ophthalmology, Univ Eye Hospital
Tuebingen, Tuebingen, Germany; 2Department
of Orthodontics, university hospital tuebingen,
Tuebingen, Germany; 3Department of Pediatric
and Operative Dentistry, Periodontology and
Endodontology, university hospital tuebingen,
Tuebingen, Germany; 4Department of Clinical
Epidemiology and Applied Biostatistics, university
hospital tuebingen, Tuebingen, Germany *CR
3990 — D0403 Time Course and Predictors of
Amblyopia Improvement with 2 Hours of Daily
Patching. David Wallace1, E. Lazar2, D. Hoover3,
S. Tamkins4. 1Duke Eye Center, Durham, NC;
2
Pediatric Eye Disease Investigator Group, Jaeb
Center for Health Research, Tampa, FL; 3Everett
and Hurite Ophthalmic Association, Cranberry, PA;
4
Bascom Palmer Eye Institute, Miami, FL *CR, f
3991 — D0404 Effect of Amblyopia Treatment
on Macular Thickness in Myopic Anisometropic
Amblyopic Eyes. Yi Pang, K. A. Frantz, S. S. Block,
G. Goodfellow, C. Allision. Illinois College of
Optometry, Chicago, IL
3992 — D0405 An Evaluation of the Effects
of a Novel Game Therapy and Conventional
Patching Treatment for Adult Amblyopia:
A Preliminary Report. Indu Vedamurthy1, M.
Nahum2, J. D. Bayliss3, D. Bavelier1, 4, D. M.
Levi2. 1Brain & Cognitive Sciences, University of
Rochester, Rochester, NY; 2School of Optometry,
University of California at Berkeley, Berkeley, CA;
3
School of Interactive Games and Media, Rochester
Institute of Technology, Rochester, NY; 4FPSE,
University of Geneva, Geneva, Switzerland *CR
3995 — D0408 Improvement of fixational
stability in strabismic amblyopes with ocular
alignment and binocular summation. Rajkumar
Nallour Raveendran1, R. J. Babu1, 2, R. F. Hess2,
W. R. Bobier1. 1School of Optometry and Vision
Science, University of Waterloo, Waterloo, ON,
Canada; 2Ophthalmology, McGill University,
Montreal, QC, Canada
3996 — D0409 Dichoptic and Monocular
Masking in Strabismic Amblyopia. Xin Jie Lai, S.
P. McKee. Smith-Kettlewell Eye Research Institute,
San Francisco, CA
3997 — D0410 Binocular summation of
luminance and chromatic contrast stimuli in
children with unilateral or bilateral amblyopia.
Mei Ying Boon1, C. M. Suttle1, H. Leung2, S. Hing3,
T. Yap1, C. D. Luu4. 1School of Optometry & Vision
Science, University of New South Wales, Sydney,
NSW, Australia; 2Ophthalmology Clinic, Office
of Dr Harry Leung, Hurstville, NSW, Australia;
3
Ophthalmology Clinic, Office of Dr Stephen
Hing, Hurstville, NSW, Australia; 4Centre for Eye
Research Australia Ltd, University of Melbourne,
Melbourne, VIC, Australia
3998 — D0411 Choroidal thickness in children
with anisohypermetropic amblyopia. Tomo Nishi,
N. Ogata. Ophthalmology, Nara medical university,
Kashihara, Japan
3999 — D0412 A comparison between
subfoveal choroidal thickness and axial length in
preschool children with hyperopic anisometropic
amblyopia. Takafumi Mori1, Y. Sugano1, I.
Maruko1, T. Hashimoto1, 2, K. Yago1, 3, T. Sekiryu1.
1
Ophthalmology, Fukushima Medical University,
Fukushima, Japan; 2Sakuramizu Sakai Eye Clinic,
Fukushima, Japan; 3Ophthalmorlogy, Northern
Fukushima Medical Center, Date, Japan
3993 — D0406 Suppression Mapping in
Amblyopia. An investigation into the gradient
and depth of suppression. William R. Bobier1, R.
J. Babu2, 1, S. R. Clavagnier2, B. Thompson3. 1School
of Optometry and Vision Science, University of
Waterloo, Waterloo, ON, Canada; 2McGill Vision
Research, Dept. Ophthalmology, McGill University,
McGill University, Montreal, QC, Canada; 3School
of Optometry, University of Auckland, Auckland,
New Zealand *CR
3994 — D0407 Interocular suppression within
the visual cortex of adults with strabismic
amblyopia: an fMRI study. Benjamin Thompson1,
G. Maehara2, R. Farivar3, B. Mansouri4, S. R.
Clavagnier3, R. F. Hess3. 1Optometry and Vision
Science, University of Auckland, Auckland, New
Zealand; 2Human Sciences, Kanagawa University,
Kanagawa, Japan; 3Ophthalmology, McGill
University, Montreal, QC, Canada; 4Ophthalmology,
Harvard University, Boston, MA *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
263
Tuesday Posters
2:45 pm – 4:30 pm
3984 — D0397 Comparison of HOTV with
Lea Optotypes Using the Amblyopia Treatment
Study Protocol in 2- to 4-Year-Old Children.
Rachel C. Mercer1, T. Yamada1, D. A. Leske1, P.
S. Moke2, J. M. Holmes1. 1Ophthalmology, Mayo
Clinic, Rochester, MN; 2Jaeb Center for Health
Research, Tampa, FL
3988 — D0401 Effective amblyopia treatment
using near adds spectacle lenses alone. Jae-do
Kim1, K. J. Ciuffreda2. 1School of Optometry,
Kyungwoon University, Gumi, Republic of Korea;
2
SUNY/State College of Optometry, NY, NY
Tuesday – Keynote/Lecture
6ABC
6ABC
Tuesday, May 07, 2013 5:30 PM-6:45 PM
Tuesday, May 07, 2013 7:00 PM-8:15 PM
383 ARVO/Alcon Keynote Series
384 ARVO/Champalimaud
Award Lecture
Much recent progress in biomedical science has
resulted from the invention of molecules that enable
us to visualize or photostimulate biochemical
pathways in living cells and tissues. Such molecules
can be devised by a variety of strategies, ranging
from pure chemical design and total synthesis
to genome mining and high-throughput directed
evolution. Examples of both successes and failures
will be chosen mainly from my own experience.
The key challenge is to match one’s own neuroses
and pleasures with research challenges that will
have the widest possible impact. Tsien was awarded
the Nobel Prize for his discovery and development
of the green fluorescent protein (GFP) with two
other chemists. The multicolored fluorescent
proteins developed in Tsien’s lab are used by
scientists to track where and when certain genes are
expressed in cells or in whole organisms. Typically,
the gene coding for a protein of interest is fused
with the gene for a fluorescent protein, which
causes the protein of interest to glow inside the cell
and allows microscopists to track its location in real
time. This has become a popular technique and has
added a new dimension to the fields of molecular
biology, cell biology and biochemistry.
The 2012 António Champalimaud Vision Award,
worth a total of €1 million recognizes the
development of two novel approaches to visualizing
the living human retina in health and disease:
Optical coherence tomography (OCT) and adaptive
optics technologies (AO).
4001a — 7:00 ARVO/Champalimaud Award
Lecture Presenter. James G. Fujimoto. Electrical
Engineering & Computer Sci, Massachusetts Inst of
Technology, Cambridge, MA *CR
4001b — 7:30 ARVO/Champalimaud Award
Lecture Presenter. David R. Williams. Center for
Visual Science, University of Rochester, Rochester,
NY *CR
Tuesday Keynote/
Lecture
5:30 pm – 8:15 pm
4000 — 5:30 Engineering Phototransducing
Molecules for Fun and Profit. Roger Tsien.
University of California, San Diego, CA
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
264