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INCI: sodium olivoyl glutamate, aqua
FUNCTION: PEG-free, non ethoxylated,
vegetable surfactant based on olive oil.
It is ideal for use in combination with Olivoil
Surfactant as it optimises its detergent action. Creates excellent abundant and stable
foam.
DESCRIPTION: It is obtained through the
combination of fatty acids from olive oil,
as far as the lipophilic portion is concerned,
and the sodium salt of the amino-acid
glutamic acid, obtained from wheat gluten,
for the hydrophilic portion. The result is a
lipo-amino-acid with surface activity, mild
detergent activity with excellent foaming
power, suitable for shampoos, soaps, bath
foam, as possible examples.
tensid / surfactant
Olivoil Glutamate Surfactant
Hair Care
Ecocert
Tensid
Cosmetics
TRADENAME
Olivoil Glutamate Surfactant
DESCRIPTION
Designed to perform a mild detergent action with perceivable skin improvements,
it is the ideal partner of Olivoil Surfactant. Lipo-aminoacids show special
properties like antimicrobial effects against a wide range of microorganisms, and
can be considered non toxic and only mild irritants. In cosmetics, they satisfy the
need of surfactants with multi-functional and bio-compatible characteristics.
INCI & GENERAL COMPOSITION
sodium olivoyl glutamate (Biopolymer)
aqua (CAS 7732-18-5)
pH 6,0 - 8,0
APPEARANCE clear liquid
COLOR colorless / pale yellow
ODOR slight, neutral
APPLICATIONS
Between 2 and 10% in skin cleansing products (foam bath, shampoos).
The product is ready to use and does not require any pre-treatment.
The addition to the bulk at temerature below 40°C is recommended.
Olivoil Glutamate, when used as a delicate surfactant in shampoo, bubble bath and
body soaps, creates excellent abundant and stable foam. It can be used in a wide
range of cleansing cosmetics, for obtaining creamy touch and balanced cleansing
power. It has an optimal skin detergent action without harming or irritating it;
while, on the contrary, improving the sensorial characteristics of the detergent
formula. This surface-active agent is ideal for use in combination with Olivoil Surfactant
as it optimises its detergent action. Olivoil products are used in association
with aggressive traditional surfactants (like SLES reducing its irritant effect) in
percentages ranging from 2% to 15% depending on the desired effect.
CERTIFICATION
Ecocert certification since Nov 2006
SHELF LIFE
12 month in the original containers
General Info
Oliveoil Glutamate is a non ethoxylated, vegetal-derived surfactant. It is obtained
through the combination of fatty acids from olive oil, as far as the lipophilic portion
is concerned, and the sodium salt of the amino-acid glutamic acid, obtained from wheat
gluten, for the hydrophilic portion. The result is a lipo-amino-acid with
surface activity, mild detergent activity with excellent foaming power, suitable for
shampoos, soaps, bath foam, as possible examples.
Once applied onto the skin, for the hydrolytic action of the stratum corneum
enzymes, the external amide bond is hydrolyzed and the active agent is therefore
separated in the constituting molecules: fatty acids and glutamic acid. The free
aminoacid becomes part of NMF, while fatty acids, especially oleic and palmitoleic, for
their high skin compatibility, enrich the composition of cell membranes in
a direct way.
Designed to perform a mild detergent action with perceivable skin improvements,
it is the ideal partner of Olivoil Surfactant. Lipo-aminoacids show special properties like
antimicrobial effects against a wide range of microorganisms, and can be
considered non toxic and only mild irritants. In cosmetics, they satisfy the need of
surfactants with multi-functional and bio-compatible characteristics.
© 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller.
INCI: cetearyl alcohol, glyceryl oleate, glyceryl stearate, potassium olivoyl hydrolyzed
wheat protein
FUNCTION: PEG-free, non ethoxylated,
vegetable emulsifier based on olive oil.
DESCRIPTION: It is a lipoproteic emulsifier
that combines the unique fatty acid profile
of olive oil with the characteristic affinity of
hydrolysed wheat proteins toward the skin
surface. Suitable for sensitive and delicate
skin. It is useful to build-up anisotropic
lamellar phases O/W from vegetal oils,
by means of totally natural ingredients.
Emulsions with very pleasant white appearance and characteristic softtouch, stable
at high temperature, without addition of
co-emulsifiers. Immediate perceptions of
skinsmoothness, softness and silkiness.
emulsifier
Olivoil Emulsifier
Skin Care
Baby Care
Ecocert
Emulsifier
Cosmetics
DESCRIPTION
olivoil emulsifier is a non-ethoxylated, vegetal derived surfactant that combines the
unique fatty acid profile of olive oil with the characteristic affinity of hydrolyzed wheat
proteins toward the skin surface. the result is a new emulsifier structure with high
skin compatibility and maximum biodegradability. olivoil emulsifier is based on olivoyl
hydrolyzed wheat protein, a lipo-protein with a fatty amide structure, showing high
inter-facial activity. the result is an ‘emulsifier base’ with an outstanding emulsifying
power. this is due to its ability to mimic the ordered aggregation of water and oil
in natural systems: the liquid crystal structure. in this manner, extremely fine and
very stable emulsions are obtained, with the oil droplets surrounded by bi-layers of
amphiphilic molecules which strengthen the interface stability, thus avoiding the
coalescence. with olivoil emulsifier, the concepts of skin-compatible liquid crystals and
skin water-management become a reality. the hydro-lipidic balance of the skin, which
is significantly lowered by traditional emulsifiers, is only barely altered. the increased
capacity of the skin to retain moisture, after the application of an emulsion realized
with olivoil emulsifier can be determined. furthermore, the lipidic moiety of the olivoil
emulsifier, thanks to the relevance of saturated and unsaturated fatty acids from olive
oil, can provide a significant contribution to the anti-aging effect of the whole cosmetic
product.
INCI & GENERAL COMPOSITION
Potassium Olivoyl Hydrolyzed Wheat Protein, Cetearyl Alcohol (CAS 67762-27-0), Glyceryl
Oleate (CAS 25496-72-4), Glyceryl Stearate (CAS 31566-31-1)
pH 6,0 - 7,0
APPEARANCE solid
COLOR ivory white
ODOR faint, characteristic
CERTIFICATION
Ecocert certification since Nov 2006
SHELF LIFE
12 month in the original containers
APPLICATIONS
It is suitable for sensitive and delicate skin (dry skin & baby skin products). furthermore,
it is useful to build-up anisotropic lamellar phases o/w from vegetal oils, by means of
totally natural ingredients. emulsions with very pleasant white appearance and characteristic softtouch, stable at high temperature, without addition of co-emulsifiers, can be
obtained. their outstanding skin-feel is a very important ‘marketing plus’: immediate
perceptions of skin smoothness, softness and silkiness are easily noticeable during and
after application.
3-10% in skin-care products (o/w emulsions);
amounts from 5-10% are suggested to reach thick emulsions;
while 2-5% is usually necessary to otain fluid emulsions (with water phase gelification)
pH range: the optimum stability is between 5-7
In-Vitro Evaluations
LPO586: it does not induce any lipo-peroxidation
In-Vivo Evaluations
Skin-irritation: no reaction (20 volunteers, epicutaneous patch-test, according to draize
classification)
© 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller.
INCI: sodium olivoyl glutamate, aqua
FUNCTION: PEG-free, non ethoxylated,
vegetable surfactant based on olive oil.
It is ideal for use in combination with Olivoil
Surfactant as it optimises its detergent action. Creates excellent abundant and stable
foam.
DESCRIPTION: It is obtained through the
combination of fatty acids from olive oil,
as far as the lipophilic portion is concerned,
and the sodium salt of the amino-acid
glutamic acid, obtained from wheat gluten,
for the hydrophilic portion. The result is a
lipo-amino-acid with surface activity, mild
detergent activity with excellent foaming
power, suitable for shampoos, soaps, bath
foam, as possible examples.
tensid / surfactant
Olivoil Glutamate
Hair Care
Ecocert
Tensid
Cosmetics
TRADENAME
Olivoil Glutamate
DESCRIPTION
Designed to perform a mild detergent action with perceivable skin improvements,
it is the ideal partner of Olivoil Surfactant. Lipo-aminoacids show special
properties like antimicrobial effects against a wide range of microorganisms, and
can be considered non toxic and only mild irritants. In cosmetics, they satisfy the
need of surfactants with multi-functional and bio-compatible characteristics.
INCI & GENERAL COMPOSITION
sodium olivoyl glutamate (Biopolymer)
aqua (CAS 7732-18-5)
pH 6,0 - 8,0
APPEARANCE clear liquid
COLOR colorless / pale yellow
ODOR slight, neutral
APPLICATIONS
Between 2 and 10% in skin cleansing products (foam bath, shampoos).
The product is ready to use and does not require any pre-treatment.
The addition to the bulk at temerature below 40°C is recommended.
Olivoil Glutamate, when used as a delicate surfactant in shampoo, bubble bath and
body soaps, creates excellent abundant and stable foam. It can be used in a wide
range of cleansing cosmetics, for obtaining creamy touch and balanced cleansing
power. It has an optimal skin detergent action without harming or irritating it;
while, on the contrary, improving the sensorial characteristics of the detergent
formula. This surface-active agent is ideal for use in combination with Olivoil Surfactant
as it optimises its detergent action. Olivoil products are used in association
with aggressive traditional surfactants (like SLES reducing its irritant effect) in
percentages ranging from 2% to 15% depending on the desired effect.
CERTIFICATION
Ecocert certification since Nov 2006
SHELF LIFE
12 month in the original containers
General Info
Oliveoil Glutamate is a non ethoxylated, vegetal-derived surfactant. It is obtained
through the combination of fatty acids from olive oil, as far as the lipophilic portion
is concerned, and the sodium salt of the amino-acid glutamic acid, obtained from wheat
gluten, for the hydrophilic portion. The result is a lipo-amino-acid with
surface activity, mild detergent activity with excellent foaming power, suitable for
shampoos, soaps, bath foam, as possible examples.
Once applied onto the skin, for the hydrolytic action of the stratum corneum
enzymes, the external amide bond is hydrolyzed and the active agent is therefore
separated in the constituting molecules: fatty acids and glutamic acid. The free
aminoacid becomes part of NMF, while fatty acids, especially oleic and palmitoleic, for
their high skin compatibility, enrich the composition of cell membranes in
a direct way.
Designed to perform a mild detergent action with perceivable skin improvements,
it is the ideal partner of Olivoil Surfactant. Lipo-aminoacids show special properties like
antimicrobial effects against a wide range of microorganisms, and can be
considered non toxic and only mild irritants. In cosmetics, they satisfy the need of
surfactants with multi-functional and bio-compatible characteristics.
© 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller.
INCI:
potassium olivoyl hydrolyzed wheat protein,
aqua
FUNCTION: PEG-free vegetable surfactant
based on olive oil.
Compatible with all traditional surfactants.
DESCRIPTION: Olivoil Surfactant is
a non ethoxylated and non sulphated
vegetal-derived surfactant. It is a lipoprotein obtained through condensation
between the carboxyl group of fatty acids
derived from olive oil and the amino
group of the hydrolyzed wheat proteins.
tensid / surfactant
Olivoil Surfactant
Skin care
Hair Care
Ecocert
Tensid
Cosmetics
TRADENAME
Olivoil Surfactant
DESCRIPTION
Olivoil Surfactant is a new generation surfactant, with a mild cleansing ability and is
compatible with all traditional surfactants and most standard cosmetic ingredients.
INCI & GENERAL COMPOSITION
potassium olivoyl hydrolyzed wheat protein (Biopolymer)
aqua (CAS 7732-18-5)
pH 6,8 - 8,0
APPEARANCE clear liquid
COLOR yellow
ODOR faint, characteristics
APPLICATIONS
Between 2 and 20% in skin cleansing products (foam bath, shampoos, baby care and
personal hygiene cosmetics). Olivoil products are used in association with aggressive
traditional surfactants (like SLES reducing its irritant effect) in percentages ranging
from 2% to 15% depending on the desired effect.
CERTIFICATION
Ecocert certification since Nov 2006
In-Vivo Evaluations
Red Blood Cell test: non irritation
LPO586: it does not induce any lipo-peroxidation
Skin irritation (according to Draize classification): no reactions
SHELF LIFE 12 month in the original containers
General Info
To merely reduce the irritant effect of traditional surfactants, low percentages of Olivoil
products (2 - 5%) may be employed. Higher percentages of Olivoil products are suggested (5 - 15%) where an immediate feel of hydration, smoothness and softness wants
to be additionally achieved. Moreover, the higher is the percentage of Olivoil used, the
higher is the sensory eudermic effect obtained.
© 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller.
INCI: calcium-hydroxyapatite, aqua.
FUNCTION: adhesion to and reduction
of plaque, repair of microscopic surface
damage, remineralisation of subsurface
DESCRIPTION: calcium hydroxyapatite
is based on a formulation designed to
significantly enhance the natural salivary
remineralisation of dental enamel. it is a
good alternative to those patients unwilling to use fluorides as part of their dental
care regime.
features
- dental sensitivity
- remineralization and filling of surface lesions
- plaque clinical-physical removal
- acid antierosion
- bio-available calcium and phosphate ions
- boosts natural ability of saliva to remineralise tooth structure
alleviates
- teeth erosion
- dental white lesions
- rampant caries
- dental effects of acidic mouth
- enamel problems in newly-erupted teeth
functional ingredient
Calcium Hydroxyapatite / KALIDENT
natural
remineralising
Oral-care
Cosmetics
TRADENAME
Kalident
DESCRIPTION
the regular use of kalident-calcium hydroxyapatite over an extended period can
do much to alleviate problems caused by excessive demineralisation of dental
enamel. the use of kalident-calcium hydroxyapatite helps preventing caries or to
stabilise rampant caries, counteracting the consequences of poor oral hygiene,
acid foods and carbonated drinks. it can help prevent the dental consequences of
xerostomia or sjogren’s syndrome. it can even assist in the reversal of dental erosion and its adverse consequences.
1. adhesion to and reduction of plaque kalident-calcium hydroxyapatite has a
strong propensity to bind with protein, and adheres to plaque bacteria and glycoproteins in the oral cavity, facilitating their removal on rinsing the mouth after
brushing. this feature of hydroxyapatite has been enhanced by reduction of its
particle size through nanotechnology, so enormously increasing the surface area
to which bacterial proteins attach.
2. repair of microscopic surface damage kalident-calcium hydroxyapatite also acts
as a filler, restoring minute cracks and scratches in surface tooth enamel. reduction of its size to nanometre level has enhanced this ability of hydroxyapatite to
enter and rebuild the crystalline network at the surface defects in the enamel. by
filling minute surface lesions and restoring smoothness to the enamel, kalidentcalcium hydroxyapatite also reduces the number of sites on the tooth surface to
which plaque is likely to adhere. results of research in this area were presented at
the iadr in early 2004.
3. remineralisation of subsurface kalident-calcium hydroxyapatite, having almost
the same composition as our teeth, directly provides mineral to demineralised
subsurface areas of the tooth (incipient caries), restoring the enamel to its nearnatural state, without changing the composition of the enamel. this is in contrast
to fluorides, which are not true remineralising substances by themselves, but
promote teeth remineralisation by salivary calcium phosphate, by creating a new
substance, fluorapatite, on the tooth surface. fluorides tend to form a coating on
the surface of the enamel, in contrast to hydroxyapatite, which tends to restore
subsurface lesions from the deeper part of the lesion first. this deep restorative
effect has been enhanced by the reduction of the hydroxyapatite particle size to
two-figure nanometer size, facilitating their deeper penetration into the enamel.
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INCI & GENERAL COMPOSITION
hydroxyapatite (CAS 1306-06-5), aqua (CAS 7732-18-5)
pH 7 - 7,6
APPEARANCE solid viscose suspension
COLOR white
ODOR slightly characteristic
SHELF LIFE 12 month
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the Clinical Evidence
- interaction of small crystal form of hydroxyapatite with mutans streptococci
- a new enamel restoring agent for use after pmtc
- a new enamel restoring agent for use after bleaching
- adsorption effect of hydroxyapatite to oral streptococci
- remineralization effects of nanohydroxyapatite-containing dentifrice: a ph-cycling
study using supernatant
- remineralization by nanohydroxyapatite-containing dentifrice: a ph cycling study
using slurry
- post-bleach stain inhibition by nano-hydroxyapatite: a cyclical staining test
- restoration of post-bleach enamel gloss using a non-abrasive, nano-hydroxyapatite
conditioner
- effect of hydroxyapatite toothpaste on vital tooth color
- in vitro studies of dental plaque formation: adsorption of oral streptococci to hydroxyaptite.
General Info
over half the dry weight of human bone, 97% of dental enamel and 70% of dentine is
comprised of hydroxyapatite. human saliva, rich in calcium and phosphate ions, is a
saturated solution of hydroxyapatite. natural and synthetic hydroxyapatite have a strong
affinity with the human body, and are used widely in orthopedic and dental applications
(such as bone augmentation, dental cement, coatings for implants, etc.), as well as in
foods, as a readily absorbed dietary calcium phosphate supplement.
© 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller.
INCI: Polyglyceryl-4 Caprate
FUNCTION: This Polyglycerol Ester for
outstanding innovative cosmetic formulations; multi-purpose ester with plenty of
benefits and properties
DESCRIPTION: Soldoc PG410 is a liquid
low viscose non-ionic surfactant. based
on linear polyglycerol and fatty acid.
It Is PEG-free, hydrophilic, compatible
with all anionic & non-ionic surfactants
and has excellent solubilizing effects
with outstanding surface-active properties. With Soldoc PG410 it is easy
to formulate emulsions containing essential oils. It is high substantive, has
skin-smoothening effects, gives fantastic
sensorial skin feeling and is non-sticky.
13-15
functional ingredient
Soldoc PG410
Emulsifier
Solubilizer
Thickener
Ester
Wet Wipes
Shower Gel / Creme
Deodorant
Shampoo
Baby Care
Toiletries
Skin care
Hair Care
Cosmetics
TRADENAME
SOLDOC® PG410
DESCRIPTION
Universal emulsifier. Provides thickening properties. Acts as deodorizing agent. It
is a multi-purpose ester and has plenty of benefits and properties.
INCI & General composition
Polyglyceryl-4 Caprate
CAS 160391-93-5
Properties
- Additive
- Deodorizing agent
- Humidity regulator
- Keeps natural skin balance
- Not irritant
- Moisturizer
- Refatting agent
- Skin smoothing
- Solubilizer
- Surfactant
- Thickening agent for toiletries
- Universal Emulsifier (O/W & W/O )
Applications
- Liquid soaps
- Natural cosmetics
- Oil Bath
- Shampoos
- Toiletries
- Wet wipes
Benefits
- Cold processable
- Easy to process
- Good biodegradibility
- No nitrosamine formation
- Multifunctional
- PEG free
- Sustainable (based on native raw material
- Toxicological safe
recommended concentration: 2 - 8%
© 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller.
INCI: Neopentyl Glycol Diethylhxanoate
FUNCTION: functional, sustainable, ecological and non toxic ester with excellent
pigment dispersing properties and, due
to it’s sensoric attributes an ideal texture
agent
DESCRIPTION: Soldoc VF8 is a very
liquid low viscose non-volatile organic
functional emollient based on Neopentyl
Glycol and fatty acid. It is used as Cyclomethicone alternative as cyclomethicones
are suspicious to aid cancer and having
mutagenic impact. Compared to most
silicone components a dosage use of only
75% Soldoc is needed to achieve similar
skin feeling.
functional ingredient
Soldoc VF8
Ester
Emollient
Silicon-Replacement
Deodorant
Lipsticks & Glosses
Creams & Lotions
Oil-free formulations
Skin care
Sun Care
Lip Care
Hair Care
Baby Care
Toiletries
Color Cosmetic
Cosmetics
TRADENAME
SOLDOC® VF8
DESCRIPTION
Soldoc VF8 is a very liquid low viscose non-volatile organic functional emollient
based on Neopentyl Glycol and fatty acid.
Soldoc VF8 is used as Cyclometicone alternative as cyclometicones are suspicious
to aid cancer and having mutagenic impact.
Compared to most silicone components a dosage use of only 75% Soldoc VF4/18
is needed to achieve similar skin feeling.
The Soldoc VF8 is a functional, sustainable, ecoloigical and non toxic ester with
excellent pigment dispersing properties and, due to it’s sensoric attributes an ideal
texture agent.
Furthermore soluble in most hydrophbic solvents.
The Neopentyl glycol diethylhexanoate is additionally perfect for developing sun
screens and body lotions to feature a rich, clean and long-lasting emolliency even
for formulatione with high payload of pigments.
Neopentyl glycol diethylhexanoate is applicable in powder foundation, lipstick,
gloss and skin care.
Neopentyl glycol diethylhexanoate enhanced wearability to your facial care products and color cosmetics
INCI & General composition
Neopentyl Glycol Diethylhxanoate
REACH * GM124711-44 | CAS 28510-23-8 | EINECS 249-060-1
Properties
Binding (agent ), Excellent solvency, Fast absorbance, High /good slip, High solubilizer for UV organic absorbers / Carrier, High spreadability, Light soft skinfeel,
Moisturizer for oily skin, Non-greasy skinfeel, No unpleasant residue, Silky dry
afterfeel / Velvety, Tack-free
Applications
Decorative Cosmetics/Make-up (Blushes / Balm, Eyeliners, Eye Shadows, Face powder,
Glossy / Ultra Glossy, Lipsticks, Liquid Foundations)
Face & Body Care (Baby Products, Creams Lotions, Make-up removers)
Hair care (Conditioners, Shampoos, Styling)
Sun care (After-sun, Protection, Self-tanning, Tanning Oil)
Toiletries (Shaving, Aftershave & toners, Anti-perspirantes & Deodorants, Oral care,
Shower & Bath)
Benefits
Easy to process
Good biodegradibility
High oxidative stability
PEG free
Sustainable (based on native raw material)
Toxicological safe
Spreadab
Solubility
ility
10
9
8
7
6
5
4
3
2
1
0
Polarity
Polarity
INCI
Appearance Clear,
Ciclomethicone
SOLDOC VF8
Surface
Surface Tension
Tension
Hydration
Hydration
Product Designation
Viscosity
Viscosity
D5
Soldoc VF8
Cyclopentasiloxane
Neopentyl Glycol
Diethylhexanoate
colorless liquid
colorless liquid
Molecular Weight
Viscosity, mPa·s
Permittivity
Interfacial Tension vs. H20,
mN/m
395
3,8
2,6
356
11,7
3,9
29,5
19,2
Contact Angle on
Vitro-Skin @ 1s, degrees
2,3
18,2
0,076
0,061
Coefficient of Friction
© 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller.
INCI: hydroxyapatite, aqua
FUNCTION: Skin-friendly solid actives Sun
filter booster
DESCRIPTION: Apalight is constituted of
hydroxyapatite particles activated with
trace elements: an Association of (Zn,
Mn, Mg) (Ca)5 (PO4)3(OH) (Lactate).
Bio-functional skin-friendly mineral solid
active in sunscreen cosmetics. Apalight,
thanks to its bio-compatibility with human
body and skin, is a very effective sun-filter
booster, superior to Titanium dioxide,
without any blue-white appearance and
lower costs; moreover are avoided the
typical problems of intolerance and loss
of efficacy affecting those ingredients ,like
micronized solids, that tend to diffuse in
depth interfering with skin metabolism
actives / emotives
APALIGHT
SPF-Booster
Sun Care
Anti-Aging
Natural
Cosmetics
TRADENAME
Apalight
APPEARANCE
WHITE VISCOUS POWDER SUSPENSION
CONCENTRATION
28 - 30% suspended solids
GENERAL COMPOSITION
Association of (Zn, Mn, Mg) (Ca)5 (PO4)3(OH) (Lactate)
pH OF SUSPENSIONS
7-8
INCI:
HYDROXYAPATITE, AQUA
PRESERVATIVE
Phenonip (other available)
PARTICLE SIZE
inf. 100nm (It is a complex of nano-particles and not.)
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STORAGE CONDITIONS
Keep in original containers, well closed, in a cool (minimum suggested temperature 14° C. max 30° C.), dry, well ventilated and clean site.
APPLICATIONS
SunCare-Products, Anti-Aging-Products
RESULTS
Evaluations show that, when introduced into several types of sunscreen formulas,
APALIGHT gave better performances than TiO2, in values variable from 2 to 18%
higher than standard sunscreen grade TiO2. All tests were carried out using the COLIPA method. In other words, APALIGHT showed seemingly better or at least comparable
sunscreen efficacy as micronized titanium dioxide.
In the field of anti-age efficacy, the material proved to perform a statistically significant
soft-focus effect (by sensory evaluation) a statistical decrease of deep wrinkles and a
tendential decrease of average rugosity (by skin replica). Improved biological elasticity
and visco-elastic coefficient (measured by Cutometer) were the influenced elasticity
parameters.
© 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller.
INCI: leontopodium alpinum
meristem cell culture,
glycerine, xanthan gum
FUNCTION: the truly effective
anti-aging solution: reduction of
eye contour wrinkles, prevention
of collagen loss, firming and restructuring treatments, prevention
of aging and photo-aging
DESCRIPTION: Edelweiss is a herbaceous plant of the family Asteraceae and it
grows spontaneously on mountain ranges
from Pyrenees and Alps to Himalaya. It is
a rare and strictly protected plant
anti-oxidant anti-hyaluronidasic anti-collagenasic
natural actives
Leontopodium alpinum
Stems G
edelweiss
anti-aging
Moisturizing
Natural
Skin regeneration
Skin-care
Cosmetics
DESCRIPTION
Produced in a unique process able to physiologically
orientate the production of specific substances involved in defensive responses of the plant against
environmental physical and biological stress. Through
the in vitro culture of plant stem cells in protected
and highly controlled conditions achieves the production of these substances with considerable biological
properties.
Quercitin
Resveratrol
Vitamin C
Trolox
Chlorogenic acid
3,5-dicaffeoylquinic acid
Leontopodic acid B
Leontopodic acid A
HTN™ technology
identification of specific substances with high biological activities. Leontopodic acids A and B, chlorogenic
acid, 3,5-dicaffeoylquinic acid: antioxidant, antihyaluronidasic, anti-collagenasic activity. Phytosterols,
amino acides, polysaccharides: moisturizing and
nutrients.
ANTI-OXIDANT ACTIVITY Leontopodium alpinum
stems is rich of substances with antioxidant activity higher than that of common natural antioxidant
benchmarks. (See picture 1) * TEAC (Trolox Equivalent
Antioxidant Capacity) assay measures the antioxidant
capacity of a substance compared with that of Trolox
(set as 1).
ANTI-HYALURONIDASIC ACTIVITY Thanks to the
synergistic effect of its constituents, Leontopodium
alpinum stems GTM inhibits hyaluronidase far more
efficiently than purified leontopodic acid B.** (See
picture 2)
ANTI-COLLAGENASIC ACTIVITY Leontopodium alpinum stems inhibits collagenase thus limiting collagen degradation and skin firmness
loss.** (See picture 3) ** This test has been performed on the powder form of Leontopodium alpinum cell cultures in order to avoid experimental interferences.
0
0,5
1
1,5
2
2,5
3
3,5
TEAC units (Trolox Equivalent Antioxidant Capacity) assay measures
the antioxidant capacity of a substance compared with that of Trolox
100
% hyaluronidase inhibition
90
80
70
60
50
40
30
20
10
0
0,1
0,2
0,4
0,8
STEMS
0,8 mg/mL
leontopodic
acid B
100
% collagenase inhibition
90
80
70
60
50
40
30
20
10
0
0,5
INCI & GENERAL COMPOSITION
Glycerine, Leontopodium alpinum meristem cell culture, xanthan gum.
1
mg/mL
Recommended Concentration: 0,5 – 5 %
Formulation guidelines:
Compatible with O/W emulsions, serum, ...
pH ≤6,0
introducing during the cooling phase.
APPEARANCE
yellow amber to light brown coloured liquid with characteristic odour
Total aflatoxins absent
GMO absent
Pesticides absent
Microbiological Specifications
Total microbial count: bacteria < 100 UFC/g
fungi < 100 UFC/g
Packaging 1 Kg
Storage Store the product in the original, well closed container, in a cool, dry area
and protected from light
Shelf life 12 months
Cosmetic Uses
reduction of eye contour wrinkles
prevention of collagen loss
firming and restructuring treatments
prevention of aging and photo-aging
the Clinical Evidence
20 subjects, twice a day face treatment of 40 days with a O/W cream containing
1% of Leontopodium alpinum stems at 20 and 40 days microprofile evaluation of
the eye contour area by skin scanner.
Leontopodium alpinum stems reduces by 15% wrinkle depth of the eye contour
area after only 20 days of treatment.
© 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller.
INCI: Echinacea angustifolia cell culture
extract, Maltodextrin
FUNCTION: protection & renewal of
sensitive & tired skin
DESCRIPTION: Echinacea angustifolia
cell culture extract titrated at 25% of
echinacoside.
anti-oxidant activity
anti-inflammatory activity
stimulation of collagen production
natural actives
Echigena 25
Echinacea angustifolia powder
natural
skin-care
Cosmetics
1
Echinacoside
Trolox
Vitamin C
Rutin
0
0,25
0,5
0,75
1
1,25
1,5
1,75
2
TEAC units*
2
30
% collagen vs control
DESCRIPTION
echinacea angustifolia is a herbaceous
plant native to north america, considered
efficacious to heal cold and flu, wounds
and inflammatory processes, and as a
stimulant for the immune system. these
activities are provided by a variety of
chemical substances including polysaccharides and phenolic derivatives, such
as echinacoside, a compound belonging
to the family of the phenylpropanoids.
htn™ technology
easier purification of echinacoside, present in very low amounts in plant tissues,
to make a final product with high biological activities.
anti-oxidant activity
echinacoside has a considerable antioxidant activity higher than that of common natural antioxidant benchmarks.
(see picture 1) * teac (trolox equivalent
antioxidant capacity) assay measures the
antioxidant capacity of a substance compared with that of trolox (set as 1).
stimulation of collagen production
echigena 25tm stimulates the synthesis
of new collagen on in vitro cultures of
human fibroblasts. (see picture 2)
anti-inflammatory activity
echigena 25tm significantly inhibits the
production of the biological messenger
nitric oxide (no), thus limiting the inflammation processes and controlling blood
vessel tone. (see picture 3)
25
20
15
10
5
0
100
200
µg/mL
cosmetic uses
treatments for sensitive skins
protection from external stresses
boosting skin renewal
% NO inhibition production
100
inci
echinacea angustifolia (asteraceae)
cell cultures extract
excipient: maltodetrin
80
70
60
50
40
30
20
10
0
recommended concentration: 0,2 - 1%
3
90
100
200
400
formulation guidelines:
compatible with o/w emulsions, serum, ...
ph ≤ 5
introducing during the cooling phase.
appearance
amber-coloured powder with characteristic flavour
solubility
freely soluble in water (eur. ph. 5th
edition)
shelf life 24 months
store the product in the original, well
closed container, in a cool, dry area and
protected from light
© 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller.
µg/mL
INCI: buddleja davidii
meristem cell culture,
glycerine, xanthan gum
FUNCTION: anti-oxidant, anti-inflammatory, photoprotective & anti-collagenasic
activity, moisturizing & nutrients
DESCRIPTION: preparation of 20% of
buddleja davidii stem cells in plant glycerine, without preservatives. in the traditional medicine plants of genus buddleja
are used for their wound healing, anti-inflammatory and anti-bacterial properties.
through the in vitro culture of plant stem
cells, we achieve the production of these
substances with considerable biological
properties.
natural actives
Buddleja Davidii Stems G
summer lilac
uva-protection
anti-oxidant
anti-aging
Skin regeneration
Skin-care
Sun-care
Cosmetics
DESCRIPTION
Comprehensive approach on the 3 main
mechanisms of photoaging:
protection from UV-induced oxidative
stress, inhibition of inflammation, control
of UV-induced matrix metalloproteinase
(MMP) activation
ANTI-OXIDANT ACTIVITY
Buddleja davidii stems has an antioxidant
activity higher than other common natural antioxidant benchmarks.
(See picture 1) * IC50: concentration of a
substance required for reducing at 50%
the DPPH free radical.
ANTI-INFLAMMATORY ACTIVITY
Verbascoside shows a strong antiinflammatory activity since it induces a
dose-dependent decrease of the expression of the pro-inflammatory chemokine
IL-8 on primary cultures of human keratinocytes stimulated by TNF-alpha.
(See picture 2)
ANTI-COLLAGENASIC ACTIVITY
Thanks to the synergistic effect of its
constituents, Buddleja davidii stems inhibits collagenase more efficaciously than
purified verbascoside. (See picture 3)
INCI & GENERAL COMPOSITION
glycerine, buddleja davidii meristem cell
culture, xanthan gum.
Recommended Concentration: 0,5 – 5 %
Formulation guidelines: compatible
with O/W emulsions, serum, ... | pH ≤ 6 |
introducing during the cooling phase
APPEARANCE amber-coloured liquid
Pesticides absent
Microbiological Specifications
bacteria < 100 UFC/g
fungi < 100 UFC/g
Packaging 1 Kg
Storage Store the product in the original,
well closed container, in a cool, dry area
and protected from light
Shelf life 12 months
Cosmetic Uses
boosting skin defence to oxidative stress
protection from UVA-photodamage
prevention of aging and photoaging
effects
prevention of post-inflammatory spots
the Clinical Evidence
10 subjects
5 days daily treatment of a skin area with
a O/W cream containing
2% of Buddleja davidii stems or the
placebo
fixed dose UVA irradiation (15 J/cm2)
skin tape stripping and determination of
lipid peroxides (LPO) and total antioxidant capacity (FRAP):
before UVA irradiation
4 and 24 hours after the irradiation
Buddleja davidii stems demonstrates to
be a broad and highly effective protection against UVA-photodamage, even vs
placebo:
significant preservation of the lipid component of the skin from oxidative stress
significant increase of the antioxidant
resistance of the skin
© 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller.
INCI: glycerophosphoinositol
chloline / lysine, phonoxyethanol,
ethylhexylglycerin, aqua
FUNCTION:
against inflammation, dandruff solution,
protection: chemical & physical agents,
UVB
DESCRIPTION: Glycerophosphoinositol
(GPI) choline is an innovative sunflower
lecithin-derived active ingredient, covered by a wide international patent both
on the molecule and its cosmetic application.
anti-dandruff after-sun anti-aging
natural actives
Glycerophosphoinositol
Choline / Lysine (gpi)
Skin regeneration
anti-dandruff
Skin-care
Sun-care
Hair-care
Cosmetics
DESCRIPTION
Glycerophosphoinositol (GPI) salts are innovative sunflower lecithin derived active
ingredients, covered by a wide international patent both on the molecules and their
cosmetic application.
They are semisyntetic derivates of glycerophosphoinositol, a natural cell component
produced by lipid metabolism.
GPI acts upstream in the inflammatory cascade via an innovative mechanism of action
since it fits into an entirely physiological auto-regulating system.
protection from physical agents
GPI salts significantly suppress uvb-induced Prostaglandin E2 secretion in Normal
Human Epidermal Keratinocytes.
protection from chemical agents
GPI salts inhibit the release of pro-inflammatory cytokine IL-1alpha from keratinocytes
of 3d human epidermis system treated with sls surfactant agent.
The compound alone does not cause a detectable cytokine release.
INCI & GENERAL COMPOSITION
aqua/water, glycerophosphoinositol choline, phonoxyethanol, ethylhexylglycerin
respectively
aqua/water, glycerophosphoinositol lysine, phonoxyethanol, ethylhexylglycerin
Recommended Concentration: 1 – 10 % (corresponding to 0,1-1% GPI choline)
Formulation guidelines:
Compatible with any type of formulation (emulsions, lotions, shampoos, ...)
pH 6,0 - 7,8
stable to wide temperature and pH ranges
enhanced activity in association with phospholipids (eg. Lecithin)
APPEARANCE
GPI choline: opalescent liquid
GPI lysine: opalescent light yellow liquid
Preservatives
0,9% phenoxythanol, 0,1% ethylhexylglycerin
Packaging 1 Kg
Storage Store the product in the original closed container in a cool area
Shelf life 36 months
Cosmetic Uses
after-sun and soothing treatments
control of symptoms of sensitive and inflamed skin
control of dandruff and related symptoms (redness, itch)
prevention of photo-aging and aging (control of skin micro-inflammation)
prevention of post-inflammatory spots
the Clinical Evidence
the skin: UVB-induced erythema
(See picture 1)
GPI choline has a lenitive activity comparable to that of a 0,1% cortisonic preparation (betamethasone valerate).
20 subjects, UVB irradiation of forearms
(dosage: 2 MED), 6 hour application of
topic formulations, 48 hour quantitative
monitoring of erythema by reflectance
spectrophotometry
the scalp: the anti-dandruff activity
(See picture 2)
10 patients suffering of seborrhoeic dermatitis and dandruff of the scalp. once a
day treatment for 30 days with a 0,25%
GPI choline lotion, clinical and dermathoscopical monitoring of symptoms at the
end of treatment, GPI choline induces a
marked and rapid reduction of dandruff
and related symptoms such as itchiness
and redness.
© 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller.
INCI: centella asiatica meristem cell
culture, glycerine, xanthan gum
FUNCTION: deep firming activity to
improve skin tone & elasticity
DESCRIPTION: preparation of 20% of
centella asiatica stem cells in plant glycerine, without preservatives
anti-oxidant, anti-hyaluronidasic,
anti-inflammatory / vasoactive effect
natural actives
Centella Asiatica Stems G
tiger grass / asiatic pennywort / gotu kola
natural
skin-care
Cosmetics
1
Trolox
Rutin
CQs-CA
0
0 ,25
0 ,5
0,75
1
1,25
1,5
1,75
TEAC units*
2
100
% hyaluronidase inhibition
90
80
70
60
50
40
30
20
10
0
0,2
100
% TNF-α inhibition production
DESCRIPTION
Centella asiatica, also known as Gotu
Kola or Tiger Grass, is a small herbaceous plant of the family Apiaceae or
Umbellifereae and is native to Southeast
Asia, Australia, Madagascar and Africa.
Centella grows in very wet and marshy
areas, over 700 meters altitude, and
being aquatic, it is especially sensitive to
pollutants in the water, which are easily
incorporated into the plant. It is used in
Indian traditional medicine for the treatment of several diseases and in dermatology for the healing of wounds, burns
and varicose ulcers.
anti-oxidant activity
Centella asiatica stems G is rich of substances with antioxidant activity higher
than that of common natural antioxidant
benchmarks.
anti-hyaluronidasic activity
Hyaluronic acid is a major constituent
of the extracellular matrix of the dermis
and it is responsible for skin hydration
and elasticity. A decrease of hyaluronic
acid, due to the enzyme hyaluronidase,
produces loss of skin firmness. Thanks to
the synergistic effect of its constituents,
Centella asiatica stems G efficiently inhibits hyaluronidase up to 90%.
anti-inflamm. activity / vasoactive effect
Caffeoylquinic acids from Centella asiatica stems G exert a significant inhibition
of the production of both TNF-alpha, a
cytokine involved in the promotion of the
inflammation, and nitric oxide (NO), a
0,5
1
2
4
3
CQs-CA
90
mg/mL
rutin
80
70
60
50
40
30
20
10
0
0,1
0,2
0,4
0 ,8
mg/mL
60
50
inci
40
centella asiatica meristem cell culture,
30
glycerine,
xanthan gum
20
10
cosmetic
uses
0
firming
body0 ,8treat- mg/mL
0,1and restructuring
0,2
0,4
ments
support of anti-stretch mark treatments
control of cellulite flaws
support of treatments for blood vessel
tone disorders
recommended concentration 0,5 – 5 %
formulation guidelines:
Compatible with O/W emulsions, serum...
pH ≤ 6
introducing during the cooling phase
appearance
yellow amber liquid
Microbiological Specifications
Total microbial count: bacteria < 100 UFC/g
fungi < 100 UFC/g
shelf life 24 months
store the product in the original, well
closed container, in a cool, dry area and
protected from light
100
4
CQs-CA
90
% NO inhibition production
% TNF-α inhibition production
100
signalling
molecule which induces
3 blood
CQs-CA
90
vessel
relaxation.
Centella
asiatica
stems
rutin
G80 is useful in the control of inflammation
70
and
blood vessel tone and permeability.
rutin
80
70
60
50
40
30
20
10
0
0,1
0,2
0,4
0 ,8
mg/m L
HTN™ technology
identification of specific substances with
high biological activities whose cosmetic
use has been patented.
Mixture of caffeoylquinic acids (CQsCA) such as 3,5-dicaffeoylquinic acid,
1,3,5-tricaffeoylquinic acid: antioxidant,
anti-inflammatory and skin lightening
activity. Phytosterols, amino acides, polysaccharides: moisturizing and nutrients.
Patent protection: patent application
n. E08425406.9
© 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller.