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Audiometry , BERA, OAE HEARING ASSESSMENT: PURE TONE AUDIOMETRY Instrumentation: Audiometer & transducers Main goal: To describe and quantify the amount of hearing loss Terms Hearing threshold: “ the lowest sound pressure level, at which under specified conditions, a person gives a predetermined percentage of correct responses on repeated trial”. Threshold tested for AC and BC separately. Threshold can be tested in the unmasked (quiet) or masked condition. Sound conducted to the cochlea through the bone stimulates the cochlea in three ways: 1. Compressional / distortional bone conduction 2. Inertial bone conduction 3. Osseotympanic bone conduction Audiometric test frequencies and levels AC Frequencies: 125, 250, 500, 750, 1000, 1500, 2000, 3000, 4000, 6000, 8000 Hz. Some high-frequency audiometers can test up to 20 kHz. Levels: Usually from -10 dB HL to about 110 dB HL (not for 125, 250, and 8000 Hz) BC Frequencies: 250 through 8000 Hz. Levels: Usually from 50 dB HL at 250 Hz to about 70-80 dB HL at other frequencies Test environment Done using Attenuating headphones (supraaural and circumaural) Insert earphones Sound-treated booths (best if double-walled) Test environment, cont’d. One room: Tester and patient in the same room Two room: Tester and control equipment in one room, patient in the other. Must have adequate attenuation, 60 Hz shielding, and connections for talkback. Patient must not be able to observe the tester. Masking 1. 2. When to mask? Always during bone conduction In air conduction whenever testing with sounds of 45dB and more How much to mask? 1. For Bone Conduction minimum masking = Bt + (Am – Bm) where Bt = bone conducton threshold in test ear, Am = air conduction threshold in masked ear, and Bm = bone conduction threshold in the masked ( non-test) ear. 2. For air conduction minimum masking = At – 40 + (Am – Bm) where At = air conduction threshold in the test ear and 40 is the accepted minimum interaural attenuation for air conducted sound, & (Am – Bm) = air bone gap in masked ear 3. The maximum masking level for both: Bt + 45 Clinical Masking Nontest ear can influence thresholds of test ear Shadow curve apparent without masking Interaural attenuation varies from 40 to 80 dB with air conduction Interaural attenuation is about 0 dB with bone conduction Sounds used for masking White noise Narrow band noise Complex noise Shadow Curve Normal Hearing(2) Types of Hearing Loss Conductive Bone conduction is normal( 15dB- 20dB) but the air bone gap is 20dB or more Sensorineural Bone conduction level is more than 20dB & if the air bone gap is 15dB or lesser Mixed Bone conduction level is worse than 20dB & the air bone gap is 20dB or more Severity of Hearing Loss Why do we need it? Whether the subject has any definite audiometry disorder? Whether the hearing loss is conductive/ sensorineural/ mixed If sensorineural, then whether it is cochlear or retrocochlear The degree of hearing dysfunction For preop and postop hearing For medicolegal purposes Determine Hearing Level Establish Hearing Threshold Level (HTL or simply HL) What is threshold? With earphones or via bone, softest sound detected 50% of time In the soundfield, tests reveal response of better ear Speech Reception Threshold (SRT) is softest level possible to hear closed set of bi-syllabic words Thresholds are measured in decibels (dB) at various frequencies, reported in Hertz Speech Reception Threshold Softest level of speech that can be understood 50% of the time Bi-syllabic vocabulary may include words tailored for pediatric patients Ear specific, if earphones used Obtained via air and/or bone conduction Correlates closely with pure tone average at 500 Hz, 1000 Hz and 2000 Hz Provides estimate of hearing for speech Speech discrimination score The percentage of correctly identified words, when words from a specially prepared list called “ phonetically balanced word list” is presented to the subject. Phonetically Balanced Word Lists selection of a group of words so that each phoneme appears with the same frequency it has in the normal lexicon. Based on Thorndike-Lorge lists of words and word frequencies. So-called PB word lists-- CID W-22 Lists Four lists of 50 words each. Rollover Indices for the preceding examples Normal: (100 - 100) / 100 = 0.0 Rollover: (44 - 20) / 44 = 0.54 Cochlear: (80 - 70)/80 = 0.125 Rollover Indices of 0.45 or greater indicate a neural (VIIIth nerve) problem. Tympanometry Measurement of the change of impedance of the middle ear at the plane of the tympanic membrane as a result of changes in air pressure in the external auditory meatus. Impedance: physical and mechanical property , mixture of three parameters, viz. stiffness, mass and friction Admittance : reciprocal of impedance Compliance : reciprocal of stiffness 1. 2. 3. 1. 2. 3. 4. Pathologies with increased compliance: Ossicular chain discontinuity Scarring of the tympanic membrane Very large tympanic membrane Pathologies with decreased compliance: Otosclerosis Adhesive or secretory otitis media Tumours in the middle ear like glomus jugulare Ossicular fixation like fixed malleus syndrome Pathologies with normal compliance: 1. Eustachian tube obstruction only, without secretory changes in the middle ear Tympanometry provides objective results to determine status of middle ear Acoustic reflexes are part of the test, add diagnostic information May be obtained ipsilaterally and/or contralaterally Immittance Tests(12) Five classifications of results, referred to as Modified Jerger Classification System Type A(d), A, A(s), B and C A(d) A A(s) B C -400 -200 0 +200 Ad , ie, normal middle ear pressure with high compliance, ossicular chain discontinuity As , ie, normal middle ear pressure low compliance , otosclerosis Flat tympanogram without any pressure peak or measurable compliance Jeger’s type B Gross secretory otits media or gross adhesive changes in middle ear Negative middle ear pressure, normal compliance with a normal shape and single peak Jeger’s type C Blocked eustachian tube without collection of any significant fluid in the middle ear Acoustic/ stapedial reflex tests 1. 2. 3. 4. Principle The acoustic reflex tests help the otolaryngologist in the: Elimination of middle ear pathology Differentiation of cochlear and retrocochlear pathology Detection of some cases of brain-stem pathologies Objective estimation of average hearing threshold level On the afferent side, sound enters one earpasses through the middle ear reaches the cochleapasses through the 8th cranial nerve reaches the cochlear nucleus of the same sidepasses to the superior olivary complex in the brainstem At this level there is crossing of pathways and the efferent pathway is bilateral On the efferent side, from the centre of the reflex arc which is in the superior olivary complex of the brainstem , 7th nerve nucleus of both sides passes through the facial nerve passes through nerve to stapedius stapedius muscle on both sides muscle contraction Interpretation of stapedial reflex test Unilateral moderate or severe conductive deafness In bilateral conductive deafness In unilateral severe sensorineural deafness In bilateral sensorineural deafness In central lesions Auditory Brainstem Evoked Response [ABER] Jewett & Wilson (1971) It is an exogenous transient response recorded in the 1- 10 ms interval(fast/short) elicited best by very brief stimuli such as clicks,at moderate to high levels Introduction Auditory brainstem response (ABR) is a neurologic test of auditory brainstem function in response to auditory (click) stimuli. It’s a set of seven positive waves recorded during the first 10 seconds after a click stimuli. They are labeled as I - VII PHYSIOLOGY Auditory brainstem response (ABR) typically uses a click stimulus that generates a response from the hair cells of the cochlea, the signal travels along the auditory pathway from the cochlear nuclear complex to the inferior colliculus in mid brain generates wave I to wave V. ORIGIN OF BAEP Origin of each wave Wave Origin I Cochlear nerve II Dorsal & Ventral cochlear nucleus III Superior olivary complex IV Nucleus of lateral lemniscus V Inferior colliculus VI Medial geniculate body VII Auditory radiation(cortex Electrode placement (Montage) Cz (at vertex) (recording electrode) Ipsilateral ear lobule or mastoid process (reference electrode). Contra lateral ear lobule (act as a ground) Procedure Subject lying supine with a pillow under his head. Room should be quite. Clean the scalp & apply electrode. Check the impedance. Apply the ear phone (red for the right ear & blue for the left ear) Select the ear in the stimulator & apply masking to the opposite ear. Contd.. Stimulation rate : 11/sec. Repetition : 2000 Find out the threshold of hearing. ABR should be done at around 80dB. Start averaging process & continue until the required repetition accomplished. Calculate the peak – interpeak latencies for the ABR waves. Normal values Peak latency of a wave = less than the next higher no. wave Or just add 1 to that wave, latency will be less than that. eg. Latency of wave 1 is less than 2. Wave Latency I <2mSec. II <3 m.sec III <4 m.sec IV <5 m.sec V <6 m.sec VI <7 m.sec Normal BERA tracing showing distinct peaks BERA parameters that are studied Though seven waves can be recorded,the first five waves are commonly employed and the most prominent feature, the wave V complex, is used for threshold estimation During ABER recording the brain activity and the noise level s/b minimum Young infants often fall asleep after a feed and on testing, the stimulus intensity needs to start at around 50 db,so that a normal hearing baby is not woken by the initial test sequence Older and more disturbed children require sedation or anaesthesia for testing Effects of maturation on ABERs *from 3 months to 3 years of age, there is no significant change in the latency of wave I, but wave V latency and IV interval decreases until stable levels are reached by 18 months of age (Gorga et al 1989) The amplitude of all waves increases with age from birth,with wave I reaching adult size by 6 months and wave V by 2 years. In the newborn only wave I and wave V are clearly seen and wave III becomes prominent at about 2 weeks of age The hearing threshold is determined by the lowest stimulus intensity at which the the AEP is detectable visually As ABER is usually evoked by click stimuli,any information on hearing is mainly b/w frequencies 2kHz and 4kHz Difference b/w the observed ABER threshold and the behavioural threshold may be b/w 5-25 db Differentiation b/w conductive, cochlear and mixed losses may not be easy during ABER measurement As wave I is present at birth and there is no significant change in latency from 3 months to 3 years,definite prolongation of wave I latency would suggest a conductive hearing problem Bone conduction ABER testing may further elucidate a conductive loss The relationship b/w stimulus intensity and wave V latency is used to plot ‘latency-intensity’ function In normal hearing, with increasing intensity of stimulation, the amplitude of the waves are enhanced and the latencies are reduced,but the interwave latencies are relatively independent of click intensity ABERs also provide useful information on the neurological status .Pts with multiple sclerosis may have neuronal desynchronization which abolishes the ABER while the pure tone audiogram remains normal In infants, a prolonged I-V latency with normal threshodls would suggest neurological damage to the auditory pathways Interpretation Wave I : small amplitude, delayed or absent may indicate cochlear lesion Wave V : small amplitude, delayed or absent may indicate upper brainstem lesion I – III inter-peak latency: prolongation may indicate lower brainstem lesion. III – V inter-peak latency: prolongation may indicate upper brainstem lesion. I – V inter-peak latency: prolongation may indicate whole brainstem lesion. Shortening of wave the interval with normal latency of wave V indicate cochlear involvement. APPLICATIONS Identifying the hearing loss Classification of type of deafness (conductive or sensorineural) Contd… Identification of retro choclear patholgy Auditory brainstem response (ABR) audiometry is considered an effective screening tool in the evaluation of suspected retrocochlear pathology such as an acoustic neuroma or vestibular schwannoma. OTOACOUSTIC EMMISIONS [OAEs] First reported by Kemp(1978) They reflect a release of acoustic energy which can be recorded in EAC and are thought to originate from the OHCs of cochlea OAEs canoccur spontaneously in 40-60% of healthy ears Clinically useful OAEs are evoked OAEs Evoked OAEs Transient OAEs – in response to a click or tone burst. TOAEs are present with good low and middle frequency hearing to click stimuli TOAEs reflect a hearing threshold of 15-25db or better TOAEs can be recorded from birth, with large amplitude emissions,making this an excellent tool for screening in neonates Distortion product OAEs - occuring at intermodulation frequencies when two tones are presented simultaneously DPOAEs have been found to be absent if hearing threshold exceeds 15 db The main use of EOAEs is in 1. Screening for hearing impairment in neonates 2. Screening cooperative children with a variety of handicaps where it is not possible to perform behavioural testing 3. Monitoring of hearing in children on ototoxic agents 4. In identifying the site of a hearing impairment,as although absent in peripheral auditory disorders, they are present in central auditory disorders thank you