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Chapter 14 Care of the Patient with a Neurologic Disorder Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Overview of Anatomy and Physiology • Structural divisions Central nervous system (CNS) • Brain and spinal cord Peripheral nervous system • Somatic nervous system Sends messages from the CNS to the skeletal muscles; voluntary • Autonomic nervous system Sends messages from the CNS to the smooth muscle, cardiac muscle, and certain glands; involuntary Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 2 Overview of Anatomy and Physiology • Cells of the nervous system Neuron Neuromuscular junction Neurotransmitters • Acetylcholine; norepinephrine; dopamine; serotonin Neuron coverings Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 3 Figure 14-1 (A, B, from Thibodeau, G.A., Patton, K.T. [2007]. Anatomy and physiology. [6th ed.]. St. Louis: Mosby. ) A, Diagram of a typical neuron. B, Myelinated axon. Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 4 Overview of Anatomy and Physiology • Central nervous system Brain • • • • Cerebrum Diencephalon Cerebellum Brain stem Midbrain; pons; medulla oblongata; coverings of the brain and spinal cord; ventricles • Spinal cord Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 5 Figure 14-2 (From Thibodeau, G.A., Patton, K.T. [2007]. Anatomy and physiology. [6th ed.]. St. Louis: Mosby.) Sagittal section of the brain (note position of midbrain). Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 6 Overview of Anatomy and Physiology • Peripheral nervous system Spinal nerves Cranial nerves Autonomic nervous system • Sympathetic nervous system • Parasympathetic nervous system Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 7 Figure 14-4 (From Thibodeau, G. A., Patton, K. T. Anthony’s textbook of anatomy and physiology. [18th ed.]. St. Louis: Mosby.) Neural pathway involved in the patellar reflex. Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 8 Overview of Anatomy and Physiology • Effects of normal aging on the nervous system Loss of brain weight Loss of neurons Reduction in cerebral blood flow Decrease in brain metabolism and oxygen utilization Decreased blood supply to spinal cord causes decreased reflexes Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 9 Overview of Anatomy and Physiology • Prevention of neurological problems Avoid drug and alcohol use Safe use of motor vehicles Safe swimming practices Safe handling and storage of firearms Use of hardhats in dangerous construction areas Use of protective padding as needed for sports Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 10 Assessment of the Neurological System • History • Mental status • Level of consciousness • • • • Glasgow coma scale Language and speech Cranial nerve function Motor function Sensory and perceptual status Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 11 Laboratory and Diagnostic Examinations • Blood and urine • • • • • • Culture Drug screens Arterial blood gases Cerebrospinal fluid Computed tomography (CT) Brain scan MRI scan PET scan Lumbar puncture Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 12 Figure 14-6 (From Elkin, M.K., Perry, A.G., Potter, P.A. [2004]. Nursing interventions and clinical skills. [4th ed.]. St. Louis: Mosby.) Position and angle of the needle when lumbar puncture is performed. Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 13 Laboratory and Diagnostic Examinations • • • • • • • Electroencephalogram Myelogram Angiogram Carotid duplex Digital subtraction angiography Electromyogram Echoencephalogram Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 14 Common Disorders of the Neurological System • Headaches Etiology/pathophysiology • Skull and brain tissues are not able to feel sensory pain • Vascular headaches Migraine Cluster Hypertensive • Tension headaches • Traction-inflammation headaches Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 15 Common Disorders of the Neurological System • Headaches (continued) Clinical manifestations/assessment • Head pain • Migraine headaches Prodromal (early sign/symptom) o Visual field defects, unusual smells or sounds, disorientation, paresthesias During headache o Nausea, vomiting, light sensitivity, chilliness, fatigue, irritability, diaphoresis, edema Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 16 Common Disorders of the Neurological System • Headaches (continued) Medical management/nursing interventions • Pharmacological management Migraine headaches o Aspirin, acetaminophen, ibuprofen o Ergotamine tartrate o Codeine; Inderal • Dietary recommendations Limit MSG, vinegar, chocolate, yogurt, alcohol, fermented or marinated foods, ripened cheese, cured sandwich meat, caffeine, and pork • Psychotherapy Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 17 Common Disorders of the Neurological System • Headaches (continued) Medical management/nursing interventions • Cluster headaches Narcotic analgesics • Tension headaches Non-narcotic analgesics • Traction-inflammatory headaches Treat cause • Comfort measures Cold packs to forehead or base of skull Pressure to temporal arteries Dark room; limit auditory stimulation Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 18 Common Disorders of the Neurological System • Neuropathic pain Etiology and pathophysiology • May arise from several occurrences • The pain transmission is not fully understood Clinical manifestations • Ranges from mild to excruciating • Changes in ability to carry out ADLs Medical management/nursing implications • Pharmacological management Anticonvulsants; nonopioid analgesics; antidepressants • Comfort measures Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 19 Common Disorders of the Neurological System • Increased intracranial pressure Etiology/pathophysiology • Increase in any content of the cranium • Space-occupying lesions, cerebrospinal problems, cerebral edema Clinical manifestations/assessment • • • • Diplopia Headache Decreased level of consciousness Pupillary signs Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 20 Common Disorders of the Neurological System • Increased intracranial pressure (continued) Clinical manifestations/assessment (continued) • • • • • • • • • Widening pulse pressure Bradycardia Respiratory problems High, uncontrolled temperatures Positive Babinski’s reflex Seizures Posturing Vomiting Singultus Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 21 Common Disorders of the Neurological System • Increased intracranial pressure (continued) Medical management/nursing interventions • Treat cause if possible • Pharmacological management Corticosteroids Antacids; histamine-receptor blockers Anticonvulsants • Mechanical decompression Craniotomy Craniectomy • Internal monitoring devices Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 22 Common Disorders of the Neurological System • Disturbances in muscle tone and motor function Etiology/pathophysiology • Damage to the nervous system causes serious problems in mobility Clinical manifestations/assessment • Flaccid or hyperreflexic muscle tone • Clumsiness or incoordination • Abnormal gait Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 23 Common Disorders of the Neurological System • Disturbances in muscle tone and motor function (continued) Medical management/nursing interventions • • • • • • • Muscle relaxants Protect from falls Assess skin integrity Positioning Sit up and tuck chin when eating Encourage patient to assist with ADLs Emotional support Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 24 Other Disorders of the Neurological System • Epilepsy or seizures Etiology/pathophysiology • Transitory disturbance in consciousness or in motor, sensory, or autonomic function due to sudden, excessive, and disorderly discharges in the neurons of the brain; results in sudden, violent, involuntary contraction of a group of muscles • Types: grand mal; petit mal; psychomotor; Jacksonianfocal; myoclonic; akinetic • Status epilepticus Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 25 Other Disorders of the Neurological System • Epilepsy or seizures (continued) Clinical manifestations/assessment • Depends on type of seizure • Aura • Postictal period Medical management/nursing interventions • During seizure: Protect from aspiration and injury • Anticonvulsant medications • Surgery Removal of brain tissue where seizure occurs Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 26 Other Disorders of the Neurological System • Epilepsy or seizures (continued) Medical management/nursing interventions (continued) • • • • Adequate rest Good nutrition Avoid alcohol Avoid driving, operating machinery, and swimming until seizures are controlled • Good oral hygiene • Medic Alert tag Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 27 Degenerative Diseases • Multiple sclerosis Etiology/pathophysiology • Degenerative neurological disorder with demyelination of the brain stem, spinal cord, optic nerves, and cerebrum Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 28 Figure 14-13 (From Lewis, S.M., Heitkemper, M.M., Dirksen, S.R. [2007]. Medical-surgical nursing: assessment and management of clinical problems. [7th ed.]. St. Louis: Mosby.) Pathogenesis of multiple sclerosis. Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 29 Degenerative Diseases • Multiple sclerosis (continued) Clinical manifestations/assessment • • • • • • • Visual problems Urinary incontinence Fatigue Weakness Incoordination Sexual problems Swallowing difficulties Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 30 Degenerative Diseases • Multiple sclerosis (continued) Medical management/nursing interventions • No specific treatment • Pharmacological management Adrenocorticotropic hormone (ACTH) Steroids Valium Betaseron (interferon beta-1b) Avonex (interferon beta-1a) Pro-banthine; urecholine Bactrim, Septra, and Macrodantin Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 31 Degenerative Diseases • Multiple sclerosis (continued) Medical management/nursing interventions • • • • • Nutrition Skin care Activity Environmental controls Patient teaching Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 32 Degenerative Diseases • Parkinson’s disease Etiology/pathophysiology • Deficiency of dopamine Clinical manifestations/assessment • • • • • • Muscular tremors; bradykinesia Rigidity; propulsive gait Emotional instability Heat intolerance Decreased blinking “Pill-rolling” motions of fingers Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 33 Figure 14-14 (From Lewis, S.M., Heitkemper, M.M., Dirksen, S.R. [2007]. Medical-surgical nursing: assessment and management of clinical problems. [7th ed.]. St. Louis: Mosby.) Nigrostriatal disorders produce parkinsonism. Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 34 Degenerative Diseases • Parkinson’s disease (continued) Medical management/nursing interventions • Pharmacological management Levodopa Sinemet Artane Cogentin Symmetrol • Surgery • Activity • Nutrition Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 35 Degenerative Diseases • Alzheimer’s disease Etiology/pathophysiology • Impaired intellectual functioning • Chronic, progressive degeneration of the cells of the brain • Brain changes include plaques in the cortex, neurofibrillary tangles, and the loss of connections between cells and cell death Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 36 Degenerative Diseases • Alzheimer’s disease (continued) Clinical manifestations/assessment • Early stage Mild memory lapses; decreased attention span • Second stage Obvious memory lapses • Third stage Total disorientation to person, place, and time Apraxia; wandering • Terminal stage Severe mental and physical deterioration Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 37 Degenerative Diseases • Alzheimer’s disease (continued) Medical management/nursing interventions • Pharmacological management Agitation: Lorazepam; Haldol Dementia: Cognex; Aricept • Nutrition Finger foods; frequent feedings; encourage fluids • Safety Remove burner controls at night Double-lock all doors and windows Constant supervision Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 38 Degenerative Diseases • Myasthenia gravis Etiology/pathophysiology • Neuromuscular disorder; nerve impulses fail to pass at the myoneural junction; causes muscular weakness Clinical manifestations/assessment • • • • Ptosis; diplopia Skeletal weakness; ataxia Dysarthria; dysphagia Bowel and bladder incontinence Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 39 Degenerative Diseases • Myasthenia gravis (continued) Medical management/nursing interventions • Pharmacological management Anticholinesterase drugs o Prostigmin o Mestinon Corticosteroids • May require mechanical ventilation Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 40 Degenerative Diseases • Amyotrophic lateral sclerosis (ALS) Etiology/pathophysiology • Motor neurons in the brain stem and spinal cord gradually degenerate • Electrical and chemical messages originating in the brain do not reach the muscles to activate them • Lou Gehrig’s disease Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 41 Degenerative Diseases • Amyotrophic lateral sclerosis (ALS) (continued) Clinical manifestations/assessment • • • • Weakness of the upper extremities Dysarthria; dysphagia Muscle wasting Compromised respiratory function Medical management/nursing interventions • No cure • Rilutec (Riluzole) • Multidisciplinary ALS teams; emotional support Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 42 Degenerative Diseases • Huntington’s disease Etiology/pathophysiology • Overactivity of the dopamine pathways • Genetically transmitted Clinical manifestations/assessment • Abnormal and excessive involuntary movements (chorea) • Ataxia to immobility • Deterioration in mental functions Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 43 Degenerative Diseases • Huntington’s disease (continued) Medical management/nursing interventions • No cure; palliative treatment • Pharmacological management Antipsychotics Antidepressants Antichoreas • Safe environment • Emotional support • High-calorie diet Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 44 Vascular Problems • Stroke (cerebrovascular accident) Etiology/pathophysiology • Abnormal condition of the blood vessels of the brain: thrombosis; embolism; hemorrhage • Results in ischemia of the brain tissue Clinical manifestations/assessment • • • • Headache Sensory deficit Hemiparesis; hemiplegia Dysphasia or aphasia Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 45 Figure 14-17 (From Lewis, S.M., Heitkemper, M.M., Dirksen, S.R. [2007]. Medical-surgical nursing: assessment and management of clinical problems. [7th ed.]. St. Louis: Mosby.) Three types of stroke. Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 46 Vascular Problems • Stroke (cerebrovascular accident) (continued) Medical management/nursing interventions • Thrombosis or embolism • • • • Thrombolytics Heparin and Coumadin Decadron Neurological checks Nutritional interventions Physical, occupational, and/or speech therapy Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 47 Cranial and Peripheral Nerve Disorders • Trigeminal neuralgia Etiology/pathophysiology • Degeneration of or pressure on the trigeminal nerve; tic douloureux Clinical manifestations/assessment • Excruciating, burning facial pain Medical management/nursing interventions • Tegretol • Surgical resection of the trigeminal nerve • Avoid stimulation of face on affected side Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 48 Cranial and Peripheral Nerve Disorders • Bell’s palsy (peripheral facial paralysis) Etiology/pathophysiology • Inflammatory process involving the facial nerve Clinical manifestations/assessment • • • • • • Facial numbness or stiffness Drawing sensation of the face Unilateral weakness of facial muscles Reduction of saliva Pain behind the ear Ringing in ear or other hearing loss Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 49 Cranial and Peripheral Nerve Disorders • Bell’s palsy (peripheral facial paralysis) (continued) Medical management/nursing interventions • Pharmacological management • • • • Corticosteroids Antiviral medications Electrical stimulation Moist heat Massage of the affected area Facial exercises Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 50 Cranial and Peripheral Nerve Disorders • Guillain-Barré syndrome Etiology/pathophysiology • Inflammation and demyelination of the peripheral nervous system • Possibly viral or autoimmune reaction Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 51 Cranial and Peripheral Nerve Disorders • Guillain-Barré syndrome (continued) Clinical manifestations/assessment • Symptoms are progressive • Paralysis usually starts in the lower extremities and moves upward; may stop at any point • Respiratory failure if intercostal muscles are affected • May have difficulty swallowing, breathing, and speaking Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 52 Cranial and Peripheral Nerve Disorders • Guillain-Barré syndrome (continued) Medical management/nursing interventions • • • • • • Adrenocortical steroids Apheresis Mechanical ventilation Gastrostomy tube Meticulous skin care Range-of-motion exercises Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 53 Cranial and Peripheral Nerve Disorders • Meningitis Etiology/pathophysiology • Acute infection of the meninges • Bacterial or aseptic • Increased incidence in winter and fall months Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 54 Cranial and Peripheral Nerve Disorders • Meningitis (continued) Clinical manifestations/assessment • • • • • • • Headache; stiff neck Irritability; restlessness Malaise Nausea and vomiting Delirium Elevated temperature, pulse, and respirations Kernig’s and Brudzinski’s signs Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 55 Cranial and Peripheral Nerve Disorders • Meningitis (continued) Medical management/nursing interventions • Pharmacological management Antibiotics o Massive doses o Multiple types o IV or intrathecal Corticosteroids Anticonvulsants Antipyretics • Dark, quiet room Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 56 Cranial and Peripheral Nerve Disorders • Encephalitis Etiology and pathophysiology • Acute inflammation of the brain caused by a virus Clinical manifestations • • • • Headache Fever Seizures Change in LOC Medical management and nursing interventions • Primarily supportive Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 57 Cranial and Peripheral Nerve Disorders • West Nile virus Etiology and pathophysiology • Principal route of infection through the bite of an infected mosquito Clinical manifestations • • • • Fever Headache Back pain Myalgia Prevention Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 58 Cranial and Peripheral Nerve Disorders • Brain abscess Etiology and pathophysiology • Accumulation of pus within the brain tissue Clinical manifestations • • • • Headache Fever Drowsiness, changes in LOC Seizures Medical management/nursing interventions • Antimicrobial therapy • Supportive care Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 59 Cranial and Peripheral Nerve Disorders • Acquired immunodeficiency syndrome Etiology and pathophysiology • Symptoms may develop from the infection with HIV or as a result of an associated infection Clinical manifestations • AIDS dementia complex (ADC) • Memory loss • Global cognitive dysfunction Medical management/nursing interventions • Antiviral, antifungal, antibacterial agents • Anticonvulsants • Safety Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 60 Cranial and Peripheral Nerve Disorders • Brain tumors Etiology/pathophysiology • Benign or malignant • Primary or metastatic • May affect any area of the brain Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 61 Cranial and Peripheral Nerve Disorders • Brain tumors (continued) Clinical manifestations/assessment • • • • • • • • Headache Hearing loss Motor weakness Ataxia Decreased alertness and consciousness Abnormal pupil response and/or unequal size Seizures Speech abnormalities Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 62 Cranial and Peripheral Nerve Disorders • Brain tumors (continued) Medical management/nursing interventions • Surgical removal of tumor Craniotomy Intracranial endoscopy • Radiation • Chemotherapy • Combination of above Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 63 Trauma • Craniocerebral trauma Etiology/pathophysiology • Motor vehicle and motorcycle accidents, falls, industrial accidents, assaults, and sports trauma • Direct trauma: Head is directly injured • Indirect trauma: Tension strains and shearing forces • Open head injuries • Closed head injuries • Hematomas Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 64 Trauma • Craniocerebral trauma Clinical manifestations/assessment • • • • • • • • Headache Nausea Vomiting Abnormal sensations Loss of consciousness Bleeding from ears or nose Abnormal pupil size and/or reaction Battle’s sign Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 65 Trauma • Craniocerebral trauma (continued) Medical management/nursing interventions • • • • • Maintain airway Oxygen Mannitol and dexamethasone Analgesics Anticonvulsants Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 66 Trauma • Spinal cord trauma Etiology/pathophysiology • Automobile, motorcycle, diving, surfing, other athletic accidents, and gunshot wounds • Fracture of vertebra • Complete cord injury • Incomplete cord injury Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 67 Figure 14-24 (From Lewis, S.M., Heitkemper, M.M., Dirksen, S.R. [2007]. Medical-surgical nursing: assessment and management of clinical problems. [7th ed.]. St. Louis: Mosby.) Mechanisms of spinal injury. Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 68 Trauma • Spinal cord trauma (continued) Clinical manifestations/assessment • • • • Loss of muscle function depends on level of injury Spinal shock Autonomic dysreflexia Sexual dysfunction Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 69 Trauma • Spinal cord trauma (continued) Medical management/nursing interventions • Realignment of bony column for fractures or dislocations: Immobilization; skeletal traction Surgery for spinal decompression • Methylprednisolone • Mobility: Slowly increase sitting up • Urinary function: Foley catheter; bladder training Intermittent catheterization • Bowel program Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 70 Nursing Process • Nursing diagnoses Autonomic dysreflexia Communication, impaired Coping, compromised family Disuse syndrome, risk for Grieving Infection, risk for Knowledge, deficient Memory, impaired Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 71 Nursing Process • Nursing diagnoses (continued) Mobility, impaired physical Nutrition, imbalanced: less than body requirements Pain, acute, chronic Self-care deficit Swallowing, impaired Thought process, disturbed Tissue perfusion (cerebral), ineffective Mosby items and derived items © 2011, 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Slide 72 Chapter 16 Central and Peripheral Nervous System Medications Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 73 Learning Objectives Identify the major classes of drugs that affect the central nervous system List different actions of antimigraine products Explain the major actions of drugs used to treat disorders of the central nervous system Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 74 Nervous System Central nervous system Peripheral nervous system Neurotransmitters Adrenergic fibers Cholinergic fibers Receptors: alpha1, alpha2, beta Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 75 Central Nervous System Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 76 Antimigraine Agents Action Block nerve impulses at receptors of the sympathetic nervous system Relieve pain by narrowing dilated cerebral arteries Uses Prevention and treatment of migraine headaches Drug Table 16-1 Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 77 Antimigraine Agents (cont.) Adverse Reactions Drug Interactions Other vasoconstrictors, MAOIs Nursing Implications and Patient Teaching Assessment Diagnosis Planning Implementation Evaluation Patient Teaching: administration considerations Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 78 Anticonvulsants or Antiepileptic Drugs Seizures: sudden muscle contractions that happen without conscious control Etiology: disease or disorders; head injury; idiopathic Four major drug classes Drug Table 16-3 Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 79 Barbiturates Action Long duration of action and sedative effect on the brain; action occurs in the brainstem Uses Status epilepticus; to prevent and control grand mal seizures May treat seizures caused by tetanus, fever, or drugs Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 80 Benzodiazepines Action CNS depressants; suppress electrical discharge in seizures Uses Treat minor motor seizures; Lennox-Gastaut syndrome (petit mal) Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 81 Hydantoins Action Work primarily on the motor cortex, where they stop the spread of seizure activity by increasing or decreasing Na+ ion movement across the motor cortex during the generation of nerve impulses Uses Grand mal and psychomotor seizures, status epilepticus, migraines, and trigeminal neuralgia Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 82 Succinimides Action and Uses Elevation of the seizure threshold in the cortex and basal ganglia and reduced synaptic response to low-frequency repetitive stimulation; controls petit mal seizures Adverse Reactions Drug Interactions Other antiseizure agents and bone marrow– depressing drugs Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 83 Succinimides (cont.) Nursing Implications and Patient Teaching Assessment Diagnosis Planning Implementation Evaluation Patient Teaching Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 84 Antiemetic-Antivertigo Agents Action Factors that may provoke nausea and vomiting: some drugs, metabolic disorders, radiation, motion, gastric irritation, vestibular neuritis, or increases in central trigger zone dopamine levels or vomiting center acetylcholine levels Agents act to redirect stimulation by stopping or reducing stimulation of the vomiting center Uses Prevent and treat motion sickness or the nausea and vomiting that occur with surgery, anesthesia, and cancer treatment Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 85 Antiemetic-Antivertigo Agents (cont.) Adverse Reactions Drowsiness and drug tolerance with longterm therapy Anticholinergic effects Drug Interactions CNS depressants Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 86 Antiemetic-Antivertigo Agents (cont.) Nursing Implications and Patient Teaching Assessment: patient history Diagnosis Planning Secondary problems: nutrition and hydration Implementation Evaluation Patient Teaching Drug Table 16-4 Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 87 Antiparkinsonian Agents Actions Change the neurotransmitters produced in the brain: excessive acetylcholine, deficient dopamine Block the uptake of acetylcholine and elevate the functional levels of dopamine in the motor regulatory centers Uses Control of the symptoms of Parkinson disease Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 88 Antiparkinsonian Agents (cont.) Adverse Reactions Dysrhythmias, muscle twitching, GI symptoms, etc. Anticholinergic agents Drug Interactions Many; read product information closely Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 89 Antiparkinsonian Agents (cont.) Nursing Implications and Patient Teaching Assessment Diagnosis Planning Implementation Evaluation Patient Teaching Drug Table 16-5 Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 90 Psychotherapeutic Agents Antianxiety Medications Antidepressants Antipsychotic Drugs Antimanic Drugs Sedative-Hypnotic Medications Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 91 Antianxiety Agents Drug Table 16-6 Anxiety is common Problematic when it interferes with a person’s ability to perform activities of daily living Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 92 Antianxiety Agents (cont.) Action Produce a calming effect Uses Relieve anxiety, tension, and fear May be used to manage alcohol withdrawal symptoms; used preoperatively; used to relieve muscle spasm Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 93 Antianxiety Agents (cont.) Adverse Reactions Drug Interactions Increase effects Antagonize effects Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 94 Antianxiety Agents (cont.) Nursing Implications and Patient Teaching Assessment Diagnosis Planning Implementation Evaluation Patient and Family Teaching Dosing; appointments and follow-up; adverse reactions; safety with storage; drug and alcohol interactions Habit-forming: should be used for the shortest time possible Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 95 Attention Deficit Hyperactivity Disorder (ADHD) Characteristics CNS stimulants Monitoring Adverse effects Patient counseling Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 96 Sedative-Hypnotic Medications Action and Uses Sedative agent: relaxes the patient and allows him or her to sleep Hypnotic agent produces sleep in the patient Used to relax patients and induce sleep before medical testing and surgical procedures; used to treat insomnia caused by mental and physical stress Drug Tables 16-13, 16-14, 16-15 Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 97 Sedative-Hypnotic Medications (cont.) Adverse Reactions Drug Interactions Nursing Implications and Patient Teaching Copyright © 2013, 2010, 2006, 2003, 2000, 1995, 1991 by Mosby, an imprint of Elsevier Inc. 98