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EDITORIAL Powerhouse little thing Paulo E.C. Dantas Editor-in-Chief Dear VPA readers, In this last 2016 issue of Vision Pan-America, The Pan-American Journal of Ophthalmology, we are pleased to bring and present to you a collection of interesting scientific articles ranging from basic science to relevant clinical cases. Of note, in an elegant review on Leber’s Hereditary Optic Neuropathy, Kogachi et al1 call our attention to a serious neurophthalmological condition that can lead to rapid, subacute vision loss. Many questions concerning its pathophysiology have remained unanswered. The authors bring new information on this intriguing disease. Intriguing also is to know that the pathophysiology of this disease is linked to this small and powerful cell organelle called mitochondrion (displayed in our front cover). You probably have heard of it during your earlier years in school but certainly (as I did) forget about how important it is to have them working right. Mitochondria have been described as “the powerhouse of the cell”, because they generate most of the cell’s supply of ATP, used as a source of chemical energy. Now, scientists are looking for ways of fixing this mitochondrially-inherited condition. We hope you enjoy the issue! Reference 1. Kogachi K, Ter--Zakarian A, Tian J, Karanjia R, Sadun A. The elusive pathophysiology of Leber’s hereditary optic neuropathy. VIS. PAN-AM. 2016; 15(4): 102-105 PS: On behalf of the Editorial Board, we would like to thank you all (readers, reviewers, secretaries and the Editorial Board) and wish you a wonderful Holiday Season and a happy 2017. See you soon with a very special Retina issue, opening this promising year. Best regards to all of you! Paulo 100