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The Global Leader in Genetic Science for Eye Care DNA Testing for Eye Care The Problem Today Full DNA sequencing is too costly, has a slow turn-around, delivers too much data, and lacks accuracy The Avellino Solution Available Today Targeted DNA Testing for Eye Care – Simple, cheek swab – Rapid, 24-48 hours – Affordable – Accurate, no false positives or negatives – Actionable, “go/no-go” surgery decision Our Growth Strategy Build on our DNA Test Platform Business Gene Therapy $11B in 2025, CAGR 48.9% Pharmacogenomics Diagnostic Testing Global Genomics Market–$17B in 2020 2015 Large Market Opportunities Exist for our Technology in Eye Care Glaucoma 60 M worldwide 3 M United States Cataract 20-30 M worldwide 3 M US LASIK 2-3 M worldwide 350,000 United States 2015 Retina - AMD 150-200 M worldwide 2-5 M United States Avellino DNA Test Development Roadmap Moving over time from the front to the back of the eye Refractive Corneal Dystrophy Keratoconus EBMD Our market today Glaucoma Pharmacotherapy Active R&D Back of the Eye Ideas on the Drawing Board Cataract Corneal Dystrophy Keratoconus EBMD Active R&D Retina Retinits Pigmentosa Macular Degeneration Avellino Labs Technology Advantage Int’l Patent Protection 4 Granted, 3 Pending/Provisional Clinical Data Half Million and Counting Global Lab Network 9 Labs Worldwide CLIA Certified in US Standard of Care Japan and South Korea 500+ Protected Collaborative R&D California, South Korea & China Intellectual Property Portfolio US and International Patents Issued 1. System For Diagnosis Of Avellino Corneal Dystrophy 1. Method For Requesting And Checking Results Of Diagnostic Tests For Avellino Corneal Dystrophy 1. Primer For Detecting Avellino Corneal Dystrophy 1. Multi-Spot Metal-Capped Nanostructure Array Nucleic Acid Chip For Diagnosis Of Corneal Dystrophy And Preparing Method Thereof US and International Pending Patents 1. Methods For Improved Isolation Of Genomic DNA Templates For Allele Detection Pct/Us14/29466 2. Methods For Multiplex Detection Of Alleles Associated With Ophthalmic Conditions Pct/Us14/65975 3. Gene Therapy – Methods for the Treatment of Corneal Dystrophies US Provisional 62/242,204 Competition • Unique Positioning – The only company dedicated to Genetic Science in Eye Care • Competitive Strategy – – – – Exclusive focus on the ophthalmic market Rapid first-to-market products Invest in IP to erect high barriers to entry 24/7 rapid research via global lab collaboration to stay ahead • Competitive Landscape – Larger players are focused on large opportunities outside eye care • i.e. Breast Cancer & Alzheimer's Management Team Gene Lee, Chairman and Founder • • • Started Avellino Labs in 2008 in South Korea Serial Entrepreneur 20 years in Pharma & Healthcare Peter Falzon, CEO • • • Joined Avellino Labs in 2015 Public & Private Company CEO Experience 25 years in the Eye Care Industry Scott Korney, COO • • • Established Avellino Lab USA in 2012 Entrepreneur and Founder Experience 30 years in the Bio-Science Industry Scientific Advisory Board Anthony J. Aldave, MD UCLA, Jules Stein Eye Institute Chief of the Cornea and Uveitis Division Sonia Yoo, MD University of Miami, Bascom Palmer Eye Institute Professor of Ophthalmology and Chief of LASIK Services Ed Manche, MD Stanford University, Byers Stein Eye Institute Chief of Cornea and Refractive Surgery Janey Wiggs, MD, PhD Harvard University, Massachusetts Eye and Ear Infirmary Associate Director, Ocular Genomics Institute Terry Kim, MD Duke University Eye Center Chief of Cornea and External Disease Services International Medical Advisory Board Anthony J. Aldave, MD UCLA, United States John Marshall PhD King’s College, UK Zhang Fenju, MD Beijing Tongren Hosp, China Wang Qinmei, MD Wenzhou Univ, China Burkhard Dick, MD Bochum University, Germany Zhou Xingtao, MD Fudan Univ, China Francesco Carones, MD Private Practice, Italy Proprietary and Confidential Company Milestones