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Brent C. Kelly, M.D. Curriculum Vitae PRESENT POSITION AND ADDRESS: Assistant Professor of Dermatology and Dermatopathology Co-Director, Dermatopathology Labarotory Department of Dermatology University of Texas Medical Branch 301 University Blvd. Galveston, Texas 77555-0783 409-772-1911 EDUCATION: University of Texas Medical Branch Galveston, Texas Dermatopathology Fellowship July 2006-June 2007 University of Texas Medical Branch Galveston, Texas Dermatology Residency July 2003 – June 2006 University of Texas Medical Branch Galveston, Texas Internal Medicine Chief Residency July 2002 – June 2003 University of Texas Medical Branch Galveston, Texas Internal Medicine Residency July 1999 - June 2002 Louisiana State University School of Medicine New Orleans, Louisiana M.D. August 1995 - May 1999 Louisiana State University Baton Rouge, Louisiana Bachelor of Science 1989 - 1993 Major: Microbiology, Minor: Zoology BOARD CERTIFICATION: American Board of Internal Medicine Certification Examination passed August 2002 (9th Decile) Diplomat of Internal Medicine, August 2002 (Valid through 2012) American Board of Dermatology Certification Examination passed August 2006 Diplomat of the American Board of Dermatology August 2006 American Board of Dermatology, Subspecialty of Dermatopathology passed September 2007 (Valid through 2017) PROFESSIONAL WORK HISTORY: Assistant Professor of Dermatology and Dermatopathology – July 2007 to present Faculty, Consult Service Faculty, Dermatopathology Service with two Dermatopathology Fellows Faculty, Resident’s clinics, one half day/week Faculty, four half-day private clinics/week Facilitator, Practice of Medicine II, UTMB Co-Director, University of Texas Medical Branch Dermatopathology Lab Director, University of Texas Medical Branch Mohs’ and Frozen section Lab Clinical Instructor, UTMB Department of Dermatology – July 2006 – June 2007 Faculty, Dermatology Consult Service Faculty, one half-day private clinic/week Assistant Professor and Chief Resident - UTMB Department of Internal Medicine June 2002 – June 2003 Faculty, Texas Department of Corrections General Medicine Clinic Faculty, TDC General Medicine Telemedicine Clinic Facilitator, Practice of Medicine I, UTMB 2002-2003 Facilitator, Practice of Medicine II, UTMB 1999-2003 Faculty, General Internal Medicine Resident’s Clinic Faculty, General Internal Medicine Inpatient Ward Service Faculty, General Internal Medicine Consult Service COMMITTEES: UTMB Quality Assurance Committee, member 2005-2006 Graduate Medical Education Committee, member 2002-2003 Resident Advisory Committee, Department of Internal Medicine, member 2002-2003 Chief Resident Advisory Committee, member 2002-2003, 2005-2006 Clinical Advisory Committee, member 2002-2003 Quality Management Committee, member 2002-2003 Housestaff Advisory Committee, member 2001-2003 PROFESSIONAL ORGANIZATIONS AND ACTIVITIES: Fellow Member, American Society of Dermatopathology (applied May, 2008) Member, American Academy of Dermatology Member, American Medical Association Member, Alpha Omega Alpha, elected 1998 Member, American Academy of Dermatology Member, International Transplant Skin Cancer Collaborative Member, Houston Dermatological Society Member, Texas Dermatological Society Member, Medical Dermatology Society Member, American Society of Dermatologic Surgery Student Coordinator, LSUMC Musician’s Clinic, 1998-1999, LSUMC Speaker, Docs in Schools, 1995-1996, New Orleans, La. Speaker, New Orleans Outreach Program, 1996-1997 Speaker, AIM- Alliance of Internal Medicine, UTMB, Galveston, 2000 Tutor, LSUMC Department of Anatomy, 1995-1996 AWARDS AND HONORS: Faculty Teaching Award, Voted by Dermatology Residents, June, 2008 Excellence in Research Award, Department of Dermatology, June, 2006 UTMB Outstanding Resident Award nominee for 2005-2006 Department of Dermatology Medical Student Award for Teaching Excellence, awarded May 19, 2006 Winner, 2nd place podium competition, Texas Dermatologic Society Meeting, Grapevine, Texas, May, 2005 Chief Resident of Internal Medicine for 2002-2003, UTMB Department of Internal Medicine Intern of the Year, selected 1999-2000, UTMB Department of Internal Medicine Designated Texas Primary Care Resident, 1999-2000 Awarded by Texas Higher Education Coordinating Board Alpha Omega Alpha Award in Teaching Excellence, awarded May 14, 1999, LSUMC Alpha Omega Alpha, Beta Chapter, elected 1998 Dean’s List, LSU, 1991-1993 RESEARCH: In progress 2007- Current - Q Zhao, M Wahbah, B Kelly, M Eltorky, W Tang and J Dong. “Functional correlation between activation of MEK/ERK signaling and aberrant expression of tumor suppressor p16 in melanocytic lesions.” 2007- Current – Cummings J, Kelly B, Wagner R. “The predictive value of non-melanoma skin cancer biopsies with negative margins.” Honors student research project. 2007- Current – Kelly B, Petitt M, Sanchez R. “The role of TGF-β and renin-angiotensin in nephrogenic fibrosing dermopathy” 2007- Current – Scroggins L, McNeese C, Kelly B. “The role of matrix metalloproteinases and their inhibitors in nephrogenic fibrosing dermopathy” 2008- Kelly B, Wilkerson M. “Serum amyloid P levels in patients with nephrogenic fibrosing dermopathy” 2008- Shimoni T, Allison A, Kelly B. “The positive predictive value of lymphatic invasion in primary melanoma using D2-40 staining” 2008- Vickers J, Kelly B. “Spindle cells in nephrogenic systemic fibrosis do not differentiate into myofibroblasts” Institutional Pharmacologic Studies: 2008 – Sub-Principal Investigator “A multicenter, open-label, randomized to route of administration (intramuscular, subcutaneous, intradermal) study to investigate the safety and immunogenicity of the VAX102 influenza vaccine in healthy adults.” PROTOCOL VAX102-03 2007 – Sub-Principal Investigator “Evaluation of IMVAMUNE® Smallpox Vaccine with Respect to Safety and Optimization of Immune Responses by Different Vaccination Regimens in Vaccinia-Naïve Adults.” DMID Protocol No. 06–0012. Bavarian Nordic Protocol Code POX–MVA–009 2006 – Principal Investigator – Genentech Pharmaceuticals “A Phase IV Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of 1.0 mg/kg Efalizumab in Adult Subjects with Chronic Moderate or Worse Plaque Psoriasis Who Have Had an Inadequate Response to an Anti-TNF Agent” 2003-Dow Pharmaceutical Sciences “A Multicenter, Open-Label Evaluation of the Adrenal Suppression Potential of Topically Applied Desonide Gel0.05% in Pediatric Subjects with Moderate to Severe Atopic Dermatitis”. Protocol 7001G3HP-03-03 IRB #03-308 2003-Fujisawa Healthcare, Inc (Quintiles) “A Phase 3, Randomized, Double-Blind Study Comparing Twice Daily FK506 Cream 0.03% Versus Cream Vehicle in the Treatment of Atopic Dermatitis in Pediatric Patients. Protocol 03-0-183 IRB# 03-361. 2004- 3M Pharmaceuticals “Phase III Vehicle-controlled, Double-Blind Study to Assess the Safety and Efficacy of Imiquimod Cream, 5% for the Treatment of Molluscum Contagiosum in Pediatric Subjects”. Protocol 1494-IMIQ IRB #04001 2004- Dow Pharmaceutical Sciences (SFBC) “A Randomized, Evaluator-Blind, 3-Arm, Multi-Center Study to Evaluate the Safety and Efficacy of Topically Applied Desonide Gel 0.05% vs. Desonide Gel Vehicle and DesOwen Lotion for the Treatment of Pediatric Subjects with Mild to Moderate Atopic Dermatitis. Protocol # 7001-G3HP-04-03 IRB #04-070 2004-Ferndale Laboratories “An Open Label Adrenal Suppression Study of Hydrocortisone Butyrate Lotion 0.1 % Used 3x Daily in Pediatric Subjects Aged 3 Months to Less than 18 Years With Moderate to Severe Atopic Dermatitis”, Protocol Number: 04-101 IRB # 04-268 2006-Astellas Pharma US, Inc. “A Phase 3, Randomized, Double-Blind Study to Evaluate the Efficacy and Safety Daily Tacrolimus Cream-B 0.1% Versus Cream-B Vehicle in the Treatment of Psoriasis”. Protocol #04-0-205 IRB# 05-264 PRESENTATIONS AND POSTERS: “Nephrogenic fibrosing dermopathy is associated with TGF-β with no evidence of a renin-angiotensin system involvement” Presented at the Medical Dermatologic Society Interliaison meeting held in conjunction with the annual American Academy of Dermatology Meeting in San Antonio, Texas. February 1, 2008. “Update on Urticaria”, Texas Dermatologic Society Meeting, Nov 3, 2007, Galveston, TX. Poster, “Diffuse Granulomatous Dermatitis Associated with Hematologic Malignancies”, 43rd Annual American Society of Dermatopathology Meeting, Oct. 2006, Chicago, Illinois “Nephrogenic Fibrosing Dermopathy” Given to Department of Radiology, February 2007. “Transplant Dermatology” Given to Nephrology Division and Transplant team, March 2007. “Introduction to Inflammatory Reaction Patterns” Given to Department of Pathology Resident’s Noon Conference. Annually. “Vesiculobullous Diseases” Given to Department of Pathology Resident’s Noon Conference. Annually. “Basic Interpretation of a Chest X-Ray” Given to UTMB Medical Students/ Alliance of Internal Medicine, 2000 “Keeping Cool on Call” Given to UTMB Medical Students/ Alliance of Internal Medicine Quarterly Meeting during “Pearls of Wisdom”, 2000 “Minimal Change Disease in Adults” UTMB Department of Internal Medicine, 2001 “Central Venous Catheter Complications by Physicians in Training” UTMB Department of Internal Medicine, 2002 “Renal Disease and Pregnancy” UTMB Department of Internal Medicine, 2002 “Angiokeratoma Corporis Diffusum in a Patient with No Recognizable Enzyme Deficiency or Systemic Abnormalities”, Texas Dermatologic Society Meeting, Galveston, Texas, October, 2003 “Cutis Marmarata Telengiectatica Congenita”, Texas Dermatologic Society Meeting, Galveston, Texas, October, 2003 “Fox-Fordyce Disease in Two Family Members” Texas Dermatologic Society Meeting, Galveston, Texas, October, 2003 “Urticaria and Angioedema”, UTMB Department of Dermatology, Galveston, TX, Annually. “Angiokeratoma Corporis Diffusum in a Patient with No Recognizable Enzyme Deficiency or Systemic Abnormalities”, South Central Dermatology Conference, Asheville, NC, July, 2004 “Angiokeratoma Corporis Diffusum in a Patient with No Recognizable Enzyme Deficiency or Systemic Abnormalities” American Academy of Dermatology Meeting, New Orleans, La, February, 2005. “Re-introducing the Tzanck Smear”, Texas Dermatologic Society Meeting, Grapevine, Texas, May, 2005. “Re-introducing the Tzanck Smear”, UTMB Department of Dermatology, Galveston, TX, June 2005. Poster, “The Tzanck Smear Revisited”, Pediatric Dermatologic Society Meeting, San Diego, Ca, July, 2005. “Ten Controversies in TEN”, UTMB Department of Dermatology, Galveston, TX, Sept 2005. “Ulcerative Sarcoidosis in the Legs with Granulomatous Vasculitis”, John Knox Conference, October, 2005, Galveston, TX “Refractory Sneddon-Wilkinson Syndrome”, John Knox Conference, October, 2005, Galveston, Texas “Nephrogenic Fibrosing Dermopathy”, John Knox Conference, October, 2005, Galveston, Texas TEACHING RESPONSIBILITIES: Dermatopathology Faculty, Two Dermatopathology Fellows per year Dermatology Faculty, Instruction of Dermatology Residents Faculty Coordinator – Dermatology rotation for residents in other departments Facilitator, Practice of Medicine II, 2007 – current Facilitator, Practice of Medicine I, 2002-2003 Faculty Judge, UTMB National Student Research Forum 2006, 2007 Co-Director, Dermatopathology Board Review Course -This is an annual two-day review course that focuses on dermatopathology. -It is attended by 50-100 people per year from the U.S. Dermatopathology Unknown Conference -This is a weekly conference for dermatology residents Dermatopathology Textbook Conference -This is held weekly for dermatology residents Lectures in Dermatology -Multiple lectures given throughout the year to residents, faculty and rotating medical students Interderpartmental Lectures -Lectures have been given to the Departments of Radiology, Internal Medicine and Pathology Student Honors Research Ad Hoc Thesis Committee Member -Julie Cummings, 2008, “Positive predictive value of surgical margins on initial biopsy of non-melanoma skin cancer” -Conner Chan, 2008, “Location of positive surgical margins on non-melanoma skin cancer re-excisions” -Mara Dacso, 2009, “Evaluation of multi-drug therapy for leprosy using daily rifampin” Student Honors Research Project Faculty Advisor -Leslie Scroggins, “The Role of Matrix Metalloproteinases and TIMP-1 in Nephrogenic Systemic Fibrosis” Lecturer, Dermatology Interest Group, February 2007 Lecturer, Student Wellness Center, “Skin Cancer”, March 2008 TEACHING AWARDS: Department of Dermatology Medical Student Award for Teaching Excellence, awarded May 19, 2006 Alpha Omega Alpha Award in Teaching Excellence, awarded May 14, 1999, LSUMC REVIEWER/REFEREE FOR PEER-REVIEWED JOURNALS: Clinical and Experimental Dermatology Yonsei Medical Journal Acta Dermato-Venereologica HOBBIES AND INTERESTS: Musician- guitarist, instructor, and writer; digital audio home recording Family - raising three children Outdoors - hiking, adventure vacations, soccer coaching Brent C. Kelly, M.D.