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Historical Advances in Microbiology Person Contribution Effect Anton van Leeuwenhoek invented the microscope was able to create diagrams that clearly showed the three major shapes of bacteria (bacilli, cocci, spiral) Lazzaro Spallanzani conducted experiments to dispute the inspired Louis Pasteur and John Tyndall to continue experimentation microlevel theory of spontaneous that eventually disproved the doctrine of spontaneous generation generation once and for all Edward Jenner first experiemented with cowpox as an way to prevent smallpox led to some 6000 people receiving inoculations to prevent smallpox inspired Pasteur's development of vaccinations Louis Pasteur developed the germ theory of fermentation inspired the developmnet of the germ theory of disease - specific vaccines were made from a weakened or atenuated pathogens - due to his work on bacteria and vaccines, he is known as the "father of bateriology and immunology" Ignaz Philipp Semmelweis noted that illness could be spread to other patients by the treating physicians Developed a hypothesis for the first real safety precaustions in a hospital. All hands had to be carefully washed before a patient was examined. His work inspired Joseph Lister to expand on this idea of a clean environment to prevent infection. Joseph Lister prevented the growth of microorganisms by using carbolic acid in the washing or disinfection of hands and surgical tools lowered fatality rate of his surgical patients and introducted aseptic technique to medical facilities Robert Koch developed an elaborate technique of isolating and identifying specific pathogens that cause specific diseases established rules that identified specific organisms as the cause of a specific disease - 4 rules or postulates