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Stem Cells & Cancer What? Where? How? Why? Types of Stem Cells • Embryonic stem cells • Inner cell mass (~30 cells) of the blastocyst (~150 cells) • First 3-4 days after fertilization • Pluripotent - Can form all tissue types & organs • Adult stem cells • Small populations retained in various tissues & organs • Unipotent – can form only 1 cell type • Multipotent – can form into a limited # of differentiated cell types • Induced pluripotent stem cells • Retrieved from adult differentiated cells • Genetically reprogrammed to mimic embryonic stem cells Stem Cell Retrieval Cloned Stem Cell Hematopoietic stem cell Mesenchymal Stem Cells Induced pluripotent stem cells Stem Cells & Cancer