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Introduction to Medical Terminology December 2nd +3rd Most important diseases and digostical methods Medical fields and pathologies blood, lymphatic and immune system cardiovascular system nervous system endocrine system urogenital system gastrointestinal system Which answer is wrong? 0 A symptom is subjective, observed by the patient, and cannot be measured directly. 0 A sign is objectively observable by others. 0 Lesion is derived from Greek and stands for a functional error as the cause of a disease. 0 A syndrome is a disease or disorder that involves a particular group of signs and symptoms. Which answer is wrong? 0 A symptom is subjective, observed by the patient, and cannot be measured directly. 0 A sign is objectively observable by others. 0 Lesion is derived from Greek and stands for a functional error as the cause of a disease. 0 A syndrome is a disease or disorder that involves a particular group of signs and symptoms. Which answer is wrong? 0 Etiology is the cause or origin reason for a disease. 0 Iatrogenic disease indicates a disease of unknown origin. 0 Pathogenesis is the series of alteration of the body as the disease develops. 0 Prognosis (Greek foreknowledge) describes the physician‘s estimate of the propable outcome of the disease. Which answer is wrong? 0 Etiology is the cause or origin, reason for a disease. 0 Iatrogenic disease indicates a disease of unknown origin (Iatrogenic disease is caused by medical treatment). 0 Pathogenesis is the series of alteration of the body as the disease develops. 0 Prognosis (Greek foreknowledge) describes the physician‘s estimate of the propable outcome of the disease. Which answer is wrong? 0 Epicrisis describes the conditions at the outbreak of the disease 0 Anamnesis examines the patient‘s past life and personal background 0 Status präsens describes the actual condition 0 A disease is an objective disturbance within the body with or without signs wheras illness exhibits signs or symptoms. Which answer is wrong? 0 Epicrisis describes the conditions at the outbreak of the disease (Epicrisis ist the discharge summary). 0 Anamnesis examines the patient‘s past life and personal background. 0 Status präsens describes the actual condition. 0 A disease is an objective disturbance within the body with or without signs wheras illness exhibits signs or symptoms. blood, lymphatic and immune system BLOOD Blood consists of 55% of plasma (liquid part, humoral) 45% blood cells (corpuscular part) Plasma consists of „humoral factors“ metabolic and nutritive agents proteins enzyms hormons globulines Plasma without clotting factors is called serum. Blood consists of ~45% blood cells (thereoff 99% red blood cells = haematocrit) red blood cells: erythrocytes white blood cells: leucocytes platelets: trombocytes red blood cells: erythrocytes contain haemoglobin to transport of oxygen white blood cells: leucocytes cellular part of immune system platelets: trombocytes important for coagulation (clotting) Thrombosis Formation of a blood clot (thrombus) in veins and arteries involving platelets and other coagulation factors: detached thrombus is called embolus. Venous trombosis causes the risc of pulmonary embolism (in the lung). Arterial thrombosis causes the risc of Myocardial infarction and stroke. The lymphatic system consists of lymphatic vessels (thin vessel transporting lymph from the periphery towards heart) lymphoid tissue (e.g. thymus, spleen, lymph nodes) lymph (fluid similar to plasma, additionally white blood cells) By CFCF - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=44327915 The lymphatic system function: transport of fatty acids from the (small) intestine to the blood circulation; important part of immune system clinical significance: lymph node metastases, lymphadenopathy (disease associated with lymph nodes), Lymphedema (swelling of the affected body part, often as a result of surgical removal of lymph nodes The immune system allergy autoimmune diseases intolerance The immune system allergy: excessive defence reaction to harmless substances (hay fever) autoimmune diseases: immun reaction against body tissue (Hashimoto thyroiditis) intolerance: due to enzyme deficiency (lactose intolerance due to deficiency of lactase) cardiovascular system (circulatory system) cardiovascular system (circulatory system) consists of heart and blood vessels main function: transport of O², CO² and nutrients to cells, tissues and organs, including metabolic products. cardiovascular system 1) systemic circulation 2) pulmonary circulation 3) coronary circulation 4) portal vein system 1) systemic circulation left ventricle > aorta > arteries > capillaries > veins > vena cava > reight atrium (vestibule) 2) pulmonary circulation right ventricle > truncus pulmonalis > capillaries > vena pulmonalis > left atrium 3) coronary circulation “private circulatory system of the heart 4) portal vein system venous system from the heart to the liver for further metabolisation Blood pressure Blood pressure systolic pressure: pressure in the arterial system during contraction of the heart diastolic pressure: pressure in the arterial system during relaxation of the heart arterial hypertension primary (essential) hypertension results from a complex interaction of genes and environmental factors. secondary hypertension secondary hypertension results from an identifiable cause such as Cushing syndrome, thyroid abnormality, pregnancy, liquorice Image: healthy-ojas.com Hypertension is present if the resting blood pressure is persistently at or above 140/90 mmHg for most adults. Image: drugs.com Ateriosclerosis: definition: thickening, hardening and loss of elasticity of the walls of arteries (degeneration). Most common reason for death Western industrial nations. Atherosclerosis: special form, mainly associated with low density lipo-proteins (different forms of lipids (fat). High risc for narrowing of an artery (brain, heart). Stenosis abnormal narrowing in a blood vessel or other tubular structure Angina: pain due not enough blood flow due to an obstruction or spasm in the supplying artery Myocardial infarction heart attack when blood flow stops for more than a few minutes causing damage to the heart muscle. Which answer is wrong? 0 Serum without „clotting factors“ is called plasma. 0 Haematocrit descibes the amount of red blood cells in the blood in terms of percentage. 0 Thrombosis is the formation of a blood clot (trombus) in veins and arteries. 0 A thrombosis is a complex reaction involving platelets and other coagulation factors. Which answer is wrong? 0 Serum without „clotting factors“ is called plasma. (Plasma without „clotting factors“ is called serum.) 0 Haematocrit descibes the amount of red blood cells in the blood in terms of percentage. 0 Thrombosis is the formation of a blood clot (trombus) in veins and arteries. 0 A thrombosis is a complex reaction involving platelets and other coagulation factors. Which answer is wrong? 0 Venous trombosis causes the risc of pulmonary embolism (in the lung). 0 Arterial thrombosis causes the risc of pulmonary embolism (in the lung). 0 A myocardial infarction is caused by a stop of blood flow causing damage to the heart muscle. 0 Ateriosclerosis is defined by a thickening, hardening and loss of elasticity of the walls of arteries. Which answer is wrong? 0 Venous trombosis causes the risc of pulmonary embolism (in the lung). 0 Arterial thrombosis causes the risc of pulmonary embolism (in the lung). Arterial thrombosis causes the risc of Myocardial infarction and stroke. 0 A myocardial infarction is caused by a stop of blood flow causing damage to the heart muscle. 0 Ateriosclerosis is defined by a thickening, hardening and loss of elasticity of the walls of arteries. Which answer is wrong? 0 Systolic pressure is defined as the pressure in the arterial system during contraction of the heart and diastolic pressure during its relaxation. 0 Systolic pressure is defined as the pressure in the arterial system during relaxation of the heart and diastolic pressure during ist contraction. 0 Hypertension is present if the resting blood pressure is persistently at or above 140/90 mmHg. 0 Hypertension in combination with atherosclerosis increase the risc for myocardial infarction or stroke. Which answer is wrong? 0 Systolic pressure is defined as the pressure in the arterial system during contraction of the heart and diastolic pressure during its relaxation. 0 Systolic pressure is defined as the pressure in the arterial system during relaxation of the heart and diastolic pressure during ist contraction. 0 Hypertension is present if the resting blood pressure is persistently at or above 140/90 mmHg. 0 Hypertension in combination with atherosclerosis increase the risc for myocardial infarction or stroke. Nervous system central nervous system (CNS) peripheral nervous system (PNS) Nervous system central nervous system (CNS) brain, spinal cord (medulla spinalis), and brain membrane (meninges), cerebrobrospinal fluid (CSF, Liquor cerebrospinalis) peripheral nervous system (PNS) nerves connect the periphery with the spinal cord and the brain (vegetative) autonomic nervous system: not controlled by awareness, regulates breathing, hearbeat, bloodpressure digestion, sympathetic fight and flight parasympathetic rest and digest neurotransmission at the synapse Image: iseibpsychology2012.wikispaces.com Neurotransmitters are endogenous chemicals that enable neurotransmission. They transmit signals across a chemical synapse, such as in a neuromuscular junction, from one neuron (nerve cell) to another "target" neuron, muscle cell, or gland cell. Neurotransmitters are released from synaptic vesicles in synapses into the synaptic space, where they are received by receptors on other synapses. important transmitter agents dopamin noradrenalin serotonin acetylcholin histamin gaba nicotine glutamin acid Most important diseases of central nervous system Most important diseases of central nervous system stroke meningitis encephalitis encephalopathy myelopathy multiple sclerosis Stroke: Apoplexy sudden fit of paralysis and dizziness cerebral infarction: ischemia due to a vascular occlusion in a blood vessel supplying the brain cerebral hemorrhage: bleeding of a blood vessel supplying the brain subarachnoidal hemorrhage: bleeding into the space beween the brain membranes meningitis inflammation of the brain membranes encephalitis inflammation of the brain encephalopathy umbrella term for any pathology of the brain myelopathy umbrella term for any pathology of the spinal cord multiple sclerosis Multiple Sclerosis MS is a chronic disease in which the cover of nerve cells in the brain and the spinal cord are damaged. Depending on the location of the affected nerve, signs and symptoms range from physical, mental and psychatric disorders. Most important diseases of peripheral nervous system most important diseases of the peripheral nervous system neuralgia neuritis neuropathy most important diseases of the peripheral nervous system neuralgia: pain in the distribution of nerves neuritis: infammation of nerves neuropathy: umbrellaterm for diseases affecting peripheral nerves Endocrine system pineal gland pituitary gland parotid gland thyroid gland pancreas adrenal glands ovaries/testicles Important terms in the context of the function of the endocrine system hyperfunction > production of hormon is to high hypofunction > production of the hormon is too low eu-(thyroidism) > normal function dysfunction > abnormal function take care hyperplasia > to big in size (but maybe hypofunctional) hypoplasia > to small in size pineal gland (epiphysis): melatonin: regulates sleep pituitary gland (hypophysis) regulates several physiological humoral activities anterior lobe (adenohypophysis) intermediate lobe posterior lobe (neurohypophysis) parotid gland produces salvia including digestive encymes thyroid gland (Gland. thyroidea) parathyroid glands pituitary gland (hypophysis) regulates several physiological humoral activities anterior lobe (adenohypophysis) GH (growth hormone) = German STH (somatotrophic hormone) TSH (thyroid-stimulating homone) ACTH (adrenocorticotrophic hormone) FSH (follicle-stimulating hormone) LH (luteinizing homone) PRL (prolactine) intermediate lobe MSH (melanocyte-stimulating homone) posterior lobe (neurohypophysis) ADH (antidiuretic hormone, vasopressin) thyroid gland (Glandula thyroidea) regulates metabolic / cardiovascular function and growth production of thyroxine (T4), triiodothyronine, calcitonine Most important pathologies hyperthyroidism hypothroidism nodules (only ~ 5 % maligne) inflammation: Hashimoto‘s thyroiditis is an autoimmune disorder parathyroid glands production of parathyroid hormone Case report men, 52 symptoms: sleeplessness, nervousness, diarrhoea signes: tachycardia, visible and palpaple node in the thyroid gland, sonography: node 1,5 cm szintigraphy: hot spot, serum: TSH low therapy: radioiodine therapy further controls: sonography, TSH, T3, T4 Glandulae suprarenales (adrenal glands, suprarenals) adrenal cortex: cortisol, glucocorticoids aldosterone, mineralocorticoid adrenal medulla adrenaline, dopamine Glandulae suprarenales (adrenal glands, suprarenals) adrenal cortex: cortisol, glucocorticoids antiinflamatory, metabolic, aldosterone, mineralocorticoid regulation of water and electrolytes adrenal medulla adrenaline, dopamine important neurotranmitters of the vegetative nervous system. cortisol, a hormon produced in suprarenal (adrenal) gland steroids used in therapy steroidal anti-inflammatory drugs: cortison Cushing syndrome image: 111197271297.blogspot.com Which answer is wrong? 0 The most important parts of the central nervous system are the brain, spinal cord, brain membrane, cerebrobrospinal fluid. 0 Nerves connect the periphery with the spinal cord and the brain. 0 The sympathetic part of the autonomic nervous system is located in the CNS and the parasympathetic part in the PNS. 0 Neurotransmitters are released from synaptic vesicles in synapses into the synaptic space, where they are received by receptors on other synapses. Which answer is wrong? 0 The most important parts of the central nervous system are the brain, spinal cord, brain membrane, cerebrobrospinal fluid. 0 Nerves connect the periphery with the spinal cord and the brain. 0 The sympathetic part of the autonomic nervous system is located in the CNS and the parasympathetic part in the PNS. 0 Neurotransmitters are released from synaptic vesicles in synapses into the synaptic space, where they are received by receptors on other synapses. Which answer is wrong? 0 Cerebral infarction is caused by ischemia due to a vascular occlusion in a blood vessel supplying the brain. 0 Meningitis is an inflammation of the spinal cord. 0 Neuralgia is defined by pain in the distribution of nerves and neuritis by infammation of nerves. 0 Dopamin, noradrenalin, serotonin, acetylcholin, gaba, nicotine are important important transmitter agents. Which answer is wrong? 0 Cerebral infarction is caused by ischemia due to a vascular occlusion in a blood vessel supplying the brain 0 Meningitis is an inflammation of the spinal cord. (Meningitis is an inflammation of the brain membranes.) 0 Neuralgia is defined by pain in the distribution of nerves and neuritis by infammation of nerves. 0 Dopamin, noradrenalin, serotonin, acetylcholin, gaba, nicotine are important important transmitter agents. Which answer is wrong? 0 Multiple sclerosis is a chronic disease in which the cover of nerve cells in the brain and the spinal cord is damaged. 0 Multiple sclerosis is a chronic disease in which the cover of nerve cells of the peripheral nerves are damaged. 0 Depending on the location of the affected nerve, signs and symptoms od MS patients range from physical, mental and psychatric disorders. 0 Encephalomyelitis disseminata is a synonym for MS, originally created to describe the situation without mentioning the name of a this degenerative disease. Which answer is wrong? 0 Multiple sclerosis is a chronic disease in which the cover of nerve cells in the brain and the spinal cord are damaged. 0 Multiple sclerosis is a chronic disease in which the cover of nerve cells of the peripheral nerves are damaged. 0 Depending on the location of the affected nerve, signs and symptoms od MS patients range from physical, mental and psychatric disorders. 0 Encephalomyelitis disseminata is a synonym for MS, originally created to describe the situation without mentioning the name of a this degenerative disease. Which answer is wrong? 0 Pituitary gland (hypophysis) regulates several physiological humoral activities and endocrine glands. 0 Hyperfunction of the tyroid gland may result in slepplessness, nervousness, or a loss of weight. 0 The adrenal glands produce stressrelated hormones such as cortisol and adrenaline 0 Cortisol produced by the body acts protective and has no side-effects Which answer is wrong? 0 Pituitary gland (hypophysis) regulates several physiological humoral activities and endocrine glands. 0 Hyperfunction of the tyroid gland may result in slepplessness, nervousness, or a loss of weight. 0 The adrenal glands produce stressrelated hormones such as cortisol and adrenaline 0 Cortisol produced by the body acts protective and has no side-effects (endogenous Cushing syndrome)