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GENE MUTATIONS
BAD
Niagara Falls
wolf
Big Bad Wolf
1 END 3 END 5 END
7 END 9 END
Odds and Ends
GENE MUTATIONS
Target: I will be able to identify the main types of gene
mutations and predict the effects of point and frame shift
gene mutations on the organism.
Mutation: A sudden change in the structure or the
.amount of genetic material.
Some have no effect.
Some are beneficial
Some are harmful
Pg. 101
Gene Mutation: a change
that affects the genes on a
chromosome.
Types of Mutations:
1. Point Mutation: a
mutation that affects no
more than one nucleotide
in the gene.
The substitution of one
nucleotide for another
which affects the
protein that is made.
Effects: 1. Some code for the same protein.
2. Some code for a different amino acid, which
changes the protein.
3. Some produce a nonsense protein that doesn’t
get made.
Point Mutation:
DNA:
TAC
GCA
TTT
AAT
mRNA:
AUG
CGU
AAC
UUA
Amino
Leu.
Met.
Arg.
Lys.
DNA:
TAC
GTA
TTT
AAT
mRNA:
AUG
CAU
AAC
UUA
Met.
His.
Lys.
Acids:
Amino
Leu.
Acids:
Effect: Different Protein was made
Frameshift Mutation: a
gene mutation that
involves the insertion or
deletion of a nucleotide.
Effect: Usually causes
no protein to be made.
DNA:
TAC
GCA
TTT
AAT
mRNA:
AUG
CGU
AAA
UUA
Met.
Arg.
Lys.
Leu.
Amino
Acids:
DNA:
TAC
GCA
ATT
TAA
mRNA:
AUG
CCU
UAA
AUU A
Arg.
STOP
Amino
Acids:
Met.
Iso.
Effect: No Protein was made
T
Lets Practice!!!
Original Sentence: THE FAT CAT ATE THE RAT
Substitution
(Point Mutation)
Substitution
(Point Mutation)
Insertion
(Frameshift
Mutation)
THE FAT BAT ATE THE RAT
THE GAT CAT ATE THE RAT
THE GFA TCA TAT ETH ERA T
Original Sentence: THE FAT CAT ATE THE RAT
Deletion
(Frameshift
Mutation)
Summary:
THE FAT ATA TET HER AT
MUTATIONS UP CLOSE
Frameshift Mutation:
Draw an example of an insertion, then write the effect that
this mutation has on the resulting protein.
Frameshift Mutation:
Draw an example of a deletion, then write the effect that
this mutation has on the resulting protein.
Point Mutation:
Draw an example of a substitution; then write the effect that
this mutation has on the resulting protein.
Pg. 100