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Tumor cell–associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell–dependent and– independent mechanisms by Joseph S. Palumbo, Kathryn E. Talmage, Jessica V. Massari, Christine M. La Jeunesse, Matthew J. Flick, Keith W. Kombrinck, Zhiwei Hu, Kelley A. Barney, and Jay L. Degen Blood Volume 110(1):133-141 July 1, 2007 ©2007 by American Society of Hematology Generation and characterization of novel C57BL/6-derived TF cell lines. Joseph S. Palumbo et al. Blood 2007;110:133-141 ©2007 by American Society of Hematology Tumor cell-associated TF expression is not required for tumor growth or tumor angiogenesis. Joseph S. Palumbo et al. Blood 2007;110:133-141 ©2007 by American Society of Hematology TF is a crucial determinant of metastatic potential but not the TF cytoplasmic domain. Joseph S. Palumbo et al. Blood 2007;110:133-141 ©2007 by American Society of Hematology The metastatic potential of TF-expressing tumor cells is strongly dependent on circulating hemostatic system components. Joseph S. Palumbo et al. Blood 2007;110:133-141 ©2007 by American Society of Hematology Hemostatic factors support metastasis through both an NK cell-dependent mechanism and at least one additional NK cell-independent mechanism. Joseph S. Palumbo et al. Blood 2007;110:133-141 ©2007 by American Society of Hematology Immunologic depletion of NK cells establishes NK cell–independent mechanism coupling both TF and prothrombin to metastatic success. Joseph S. Palumbo et al. Blood 2007;110:133-141 ©2007 by American Society of Hematology