Download Powerpoint - Blood Journal

Tumor cell–associated tissue factor and circulating
hemostatic factors cooperate to increase metastatic
potential through natural killer cell–dependent and–
independent mechanisms
by Joseph S. Palumbo, Kathryn E. Talmage, Jessica V. Massari, Christine M. La
Jeunesse, Matthew J. Flick, Keith W. Kombrinck, Zhiwei Hu, Kelley A. Barney, and
Jay L. Degen
Blood
Volume 110(1):133-141
July 1, 2007
©2007 by American Society of Hematology
Generation and characterization of novel C57BL/6-derived TF cell lines.
Joseph S. Palumbo et al. Blood 2007;110:133-141
©2007 by American Society of Hematology
Tumor cell-associated TF expression is not required for tumor growth or tumor angiogenesis.
Joseph S. Palumbo et al. Blood 2007;110:133-141
©2007 by American Society of Hematology
TF is a crucial determinant of metastatic potential but not the TF cytoplasmic domain.
Joseph S. Palumbo et al. Blood 2007;110:133-141
©2007 by American Society of Hematology
The metastatic potential of TF-expressing tumor cells is strongly dependent on circulating
hemostatic system components.
Joseph S. Palumbo et al. Blood 2007;110:133-141
©2007 by American Society of Hematology
Hemostatic factors support metastasis through both an NK cell-dependent mechanism and at
least one additional NK cell-independent mechanism.
Joseph S. Palumbo et al. Blood 2007;110:133-141
©2007 by American Society of Hematology
Immunologic depletion of NK cells establishes NK cell–independent mechanism coupling both
TF and prothrombin to metastatic success.
Joseph S. Palumbo et al. Blood 2007;110:133-141
©2007 by American Society of Hematology