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Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis by Natalie J. Foot, Yew Ann Leong, Loretta E. Dorstyn, Hazel E. Dalton, Kristen Ho, Lin Zhao, Michael D. Garrick, Baoli Yang, Devendra Hiwase, and Sharad Kumar Blood Volume 117(2):638-646 January 13, 2011 ©2011 by American Society of Hematology Ndfip1 is important for regulating DMT1 under iron-deficient conditions in vivo. Natalie J. Foot et al. Blood 2011;117:638-646 ©2011 by American Society of Hematology Ndfip1−/− mice show increased iron uptake under low iron conditions and increased iron storage under normal iron conditions. Natalie J. Foot et al. Blood 2011;117:638-646 ©2011 by American Society of Hematology mRNA levels of genes involved in regulating iron homeostasis in Ndfip1+/+ and Ndfip1−/− mice fed either a low-, normal, or high-iron diet. Natalie J. Foot et al. Blood 2011;117:638-646 ©2011 by American Society of Hematology Ndfip1−/− mice fed a low-iron diet develop hypochromic, microcytic anemia. Natalie J. Foot et al. Blood 2011;117:638-646 ©2011 by American Society of Hematology The anemia of Ndfip1−/− mice under iron-deficient conditions is partly contributable to inflammation. Natalie J. Foot et al. Blood 2011;117:638-646 ©2011 by American Society of Hematology Removing inflammation reveals further evidence for the importance of Ndfip1 in the regulation of DMT1 in vivo. Natalie J. Foot et al. Blood 2011;117:638-646 ©2011 by American Society of Hematology