Download Powerpoint - Blood Journal

Ndfip1-deficient mice have impaired DMT1 regulation and
iron homeostasis
by Natalie J. Foot, Yew Ann Leong, Loretta E. Dorstyn, Hazel E. Dalton, Kristen Ho,
Lin Zhao, Michael D. Garrick, Baoli Yang, Devendra Hiwase, and Sharad Kumar
Blood
Volume 117(2):638-646
January 13, 2011
©2011 by American Society of Hematology
Ndfip1 is important for regulating DMT1 under iron-deficient conditions in vivo.
Natalie J. Foot et al. Blood 2011;117:638-646
©2011 by American Society of Hematology
Ndfip1−/− mice show increased iron uptake under low iron conditions and increased iron
storage under normal iron conditions.
Natalie J. Foot et al. Blood 2011;117:638-646
©2011 by American Society of Hematology
mRNA levels of genes involved in regulating iron homeostasis in Ndfip1+/+ and Ndfip1−/− mice
fed either a low-, normal, or high-iron diet.
Natalie J. Foot et al. Blood 2011;117:638-646
©2011 by American Society of Hematology
Ndfip1−/− mice fed a low-iron diet develop hypochromic, microcytic anemia.
Natalie J. Foot et al. Blood 2011;117:638-646
©2011 by American Society of Hematology
The anemia of Ndfip1−/− mice under iron-deficient conditions is partly contributable to
inflammation.
Natalie J. Foot et al. Blood 2011;117:638-646
©2011 by American Society of Hematology
Removing inflammation reveals further evidence for the importance of Ndfip1 in the regulation
of DMT1 in vivo.
Natalie J. Foot et al. Blood 2011;117:638-646
©2011 by American Society of Hematology