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Mechanical Ventilation Tariq Alzahrani M.D Assistant Professor College of Medicine King Saud University Anatomy Apex -5 Base Chest Wall -8 Lung has weight Ppl = -2 Mechanical Ventilator • • • • • • • • • Definition Indication Types Classification Modes Goals Monitor Weaning Complication Indication • Support of oxygenation –Oxygen responsive hypoxemias • Pneumonia • Sepsis • Inhalation injury –Oxygen refractory hypoxemias • Atelectasis • Aspiration / Drowning • Adult Respiratory Distress Syndrome (ARDS) • Support of ventilation –Airway compromise –Muscle fatigue / weakness –Paralysis / spinal cord injury –Neuromuscular disease –Chest wall injury Types • Non invasive Ventilation • Invasive Ventilation ETT tracheostomy Classification • Volume controlled ventilation • Pressure controlled ventilation • Time controlled ventilation Modes? AutoFlow Auto Mode VS PPS PCV Modes • • • • • • CMV AC PCV SIMV PSV Spo. V Goals • Maintain patient comfort • Allow a normal, spontaneous breathing pattern whenever possible • Maintain a PaCO2 between 35-50 mmHg • Maintain a PaO2 sufficient to meet cellular oxygen demands but avoid oxygen toxicity • Avoid respiratory muscle fatigue and atrophy PATIENT COMFORT SCALE Synchronized Intermittent Spontaneous Mechanical Ventilation Breathing Controlled Mechanical Ventilation - + Pressure Support Ventilation Assist Control Ventilation Pressure Control Ventilation SEDATIVES , ANALGESICS AND MUSCLE RELAXANTS Monitor Weaning • Factors to consider: • • • • • • • • Awake, and off sedation (as much as possible). Adequate nutrition, fluid status. Free of infection. Hemodynamically stable (preferably off pressors, angina controlled, no active bleeding) Normal acid-base status Bronchospasm controlled Normal electrolyte balance Oxygenation (O2 requirements <0.5 and PEEP <5 cmH20) • Weaning Parameters: • • • • Inspiratory negative pressure of -25 cmH2O RR<30 Vt >6-8 ml/Kg ABG status near normal Causes of failure to wean: 1. Hypoxemia • Diffuse pulmonary disease • Focal pulmonary disease (Pneumonia) • Pulmonary edema (removal of positive pressure can increase preload and lead to worsening heart failure) 2.Insufficient Ventilatory Drive: • response to metabolic alkalosis • Inadequate function of CNS drive (Ex: sedatives, malnutrition) 3. Excessive Ventilatory Drive: • Excessive CO2 production (sepsis, agitation, fever, high carbohydrate intake) 4. Respiratory Muscle Weakness: • Neuromuscular disease • Malnutrition • Drugs (Neuromuscular blocking agents, Corticosteroids,aminoglycosides) 5. Excessive Work of Breathing: • • • • • • Airway obstruction Bronchospasm Secretions Increased Raw (ETT) ETT too small Chest motion restriction (pain, bandages) 6. Acid base disorders 7. Phrenic nerve Injury (especially with contralateral pulmonary disease) Complication Ventilation-related complications: • Disconnection • Malfunction Hemodynamic effects: decreased cardiac output due to impaired venous return to the right heart and increased pulmonary venous resistance due to positive pressure alveolar distension AutoPEEP • Barotrauma or Atelectasis • Oxygen toxicity • Respiratory alkalosis • Increased intracranial pressure Suctioning-related complications: • Hypoxemia a) patients should always be pre-oxygenated with 100% oxygen prior to suctioning b) suction time should be limited • Arrhythmias • Nosocomial infections Non-invasive ventilation • Invasive vs. Non-invasive ventilation Invasive Good control of airway Suitable for higher pressures Non-invasive Avoidance of complications of intubation Avoidance of complic of invasive ventilation ( sinusitis…) If tolerated, more comfortable to awake pts. Breaks possible No sedation (or less sedation) Indication – Acute settings – Chronic disease Goals • • • • • Relieve symptoms Reduce work of breathing Improve gas exchange Minimize risk Avoid intubation Exclusion criteria 1.Respiratory arrest 2.Medically unstable 3.Unconscious, unable to protect airways 4.Excessive secretions 5.Significant vomiting 6.Agitated or uncooperative 7.Facial trauma, burns, surgery or anatomic abnormalities interfering with mask application