Download Powerpoint - Circulation Research

Ionic Remodeling Underlying Action Potential Changes in a
Canine Model of Atrial Fibrillation
by Lixia Yue, Jianlin Feng, Rania Gaspo, Gui-Rong Li, Zhiguo Wang, and Stanley
Nattel
Circulation Research
Volume 81(4):512-525
October 1, 1997
Copyright © American Heart Association, Inc. All rights reserved.
Action potential recordings from representative cells obtained from a sham-operated (P0) dog
(A) and dogs subjected to 1 (B), 7 (C), and 42 (D) days of atrial pacing at 400/min.
Lixia Yue et al. Circ Res. 1997;81:512-525
Copyright © American Heart Association, Inc. All rights reserved.
A through D, Recordings of IK1 obtained with the voltage protocol shown in the inset at 0.1 Hz in
representative cells obtained from a sham-operated dog (A) and dogs subjected to 1 (B), 7 (C),
and 42 (D) days of rapid atrial pacing.
Lixia Yue et al. Circ Res. 1997;81:512-525
Copyright © American Heart Association, Inc. All rights reserved.
A through D, Recordings of Ito obtained with the voltage protocol shown in the inset at 0.1 Hz in
representative cells obtained from a sham-operated dog (A) and dogs subjected to 1 (B), 7 (C),
and 42 (D) days of rapid atrial pacing.
Lixia Yue et al. Circ Res. 1997;81:512-525
Copyright © American Heart Association, Inc. All rights reserved.
A, Voltage dependence of inactivation (Inact) and activation (Act) of Ito in various groups of
dogs.
Lixia Yue et al. Circ Res. 1997;81:512-525
Copyright © American Heart Association, Inc. All rights reserved.
A through D, Recordings of ICl.Ca obtained with the voltage protocol shown in the inset at 0.1 Hz
in representative cells obtained from a sham-operated dog (A) and dogs subjected to 1 (B), 7 (C),
and 42 (D) days of rapid atrial pacing.
Lixia Yue et al. Circ Res. 1997;81:512-525
Copyright © American Heart Association, Inc. All rights reserved.
A through D, Recordings of IK obtained with the voltage protocol shown in the inset (3-second
activating pulse to various test potentials [TPs], followed by 1-second repolarization to −30 mV
to observe tail currents) at 0.1 Hz in representative cells obtained from a sham-operated dog (A)
and dogs subjected to 1 (B), 7 (C), and 42 (D) days of rapid atrial pacing.
Lixia Yue et al. Circ Res. 1997;81:512-525
Copyright © American Heart Association, Inc. All rights reserved.
A through D, Recordings of IKur.d obtained with the voltage protocol shown in the inset at 0.1 Hz
in representative cells obtained from a sham-operated dog (A) and dogs subjected to 1 (B), 7 (C),
and 42 (D) days of rapid atrial pacing.
Lixia Yue et al. Circ Res. 1997;81:512-525
Copyright © American Heart Association, Inc. All rights reserved.
Recordings of ICa obtained with the voltage protocol shown in the inset at 0.1 Hz in
representative cells obtained from a sham-operated dog (A) and dogs subjected to 1 (B), 7 (C),
and 42 (D) days of rapid atrial pacing.
Lixia Yue et al. Circ Res. 1997;81:512-525
Copyright © American Heart Association, Inc. All rights reserved.
A, Voltage dependence of inactivation (Inact) and activation (Act) of ICa in various groups of
dogs.
Lixia Yue et al. Circ Res. 1997;81:512-525
Copyright © American Heart Association, Inc. All rights reserved.
Properties of T-type Ca2+ current in cells from sham-operated and paced dogs.
Lixia Yue et al. Circ Res. 1997;81:512-525
Copyright © American Heart Association, Inc. All rights reserved.
Action potential recordings at 0.1 Hz (top) and corresponding drug-sensitive AP clamp
recordings (bottom) from P0 dog cells exposed to 1 (A), 5 (B), and 10 (C) μmol/L nifedipine (Nif)
and from a cell from a dog subjected to 42 days of rapid pacing exposed to 10 μmol/L Nif (D).
Lixia Yue et al. Circ Res. 1997;81:512-525
Copyright © American Heart Association, Inc. All rights reserved.
A through C, Examples of action potentials recorded at 0.1 Hz (•) and 2 Hz (♦) in cells from a
sham-operated dog (A), from a dog subjected to 42 days of rapid atrial pacing (B), and from a
sham-operated dog after exposure of the cell to 10 μmol/L nifedipine (Nif) (C).
Lixia Yue et al. Circ Res. 1997;81:512-525
Copyright © American Heart Association, Inc. All rights reserved.